Oral composition

Abstract

To provide an oral composition which effectively retains fluoride ions (F-) on tooth surfaces, suppresses decline in bactericidal effect even after storage, and exhibits excellent storage stability of visual texture (kneaded texture).SOLUTION: An oral composition comprises: (A) sodium fluoride; (B) a water-soluble calcium salt; (C) a condensed phosphate or a salt thereof; (D) at least one selected from cetylpyridinium chloride, benzalkonium chloride, and chlorhexidine hydrochloride; and (E) a water-soluble polymer compound.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to an oral composition containing fluoride ions (F - ).

Background Art

[0002] Fluorides such as sodium fluoride have a caries-preventive effect and are thus widely used as medicinal components (active ingredients) in oral compositions such as dentifrices. To effectively actuate fluorides, it is effective to retain fluoride ions (F - ) on the oral mucosa and tooth surfaces, particularly tooth surfaces, for a long time, and it is desirable to leave a large amount of fluoride ions in the oral cavity even after rinsing the oral cavity with water or gargling after use.

[0003] As a method for improving the retention of fluoride ions, a method of forming a complex by combining a water-soluble polyphosphate, a water-soluble calcium salt, and sodium fluoride has also been adopted. However, when a cationic bactericide is allowed to coexist for the purpose of imparting bactericidal power, it reacts with the complex, resulting in a decrease in the retention of fluoride ions and the bactericidal power after long-term storage.

[0004] Patent Document 1 (Japanese Patent No. 6471667) proposes a liquid oral composition comprising a combination of a fluoride salt, calcium glycerophosphate, a condensed phosphate, and a cationic bactericide. By formulating with this combination, both an excellent remineralization promoting effect and a highly persistent bactericidal effect against caries-causing bacteria are achieved. However, reduction of the bactericidal effect after long-term storage has been a problem.

Prior Art Documents

Patent Documents

[0005]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0006] The present invention has been made in view of the above circumstances, and aims to provide an oral composition that is excellent in the retention of fluoride ions (F - ) on tooth surfaces, suppresses the decrease in bactericidal power even after storage, and has excellent storage stability of the external appearance of the skin (toned skin).

Means for Solving the Problems

[0007] As a result of intensive studies to achieve the above object, the present inventors have found that the above problems can be solved by using in combination (A) sodium fluoride, (B) a water-soluble calcium salt, (C) a condensed phosphoric acid or a salt thereof, (D) at least one selected from cetylpyridinium chloride, benzalkonium chloride, and chlorhexidine hydrochloride, and (E) a water-soluble polymer compound, and thus have arrived at the present invention.

[0008] Therefore, the present invention provides an oral composition. 1. An oral composition containing (A) sodium fluoride, (B) a water-soluble calcium salt, (C) a condensed phosphoric acid or a salt thereof, (D) at least one selected from cetylpyridinium chloride, benzalkonium chloride, and chlorhexidine hydrochloride, and (E) a water-soluble polymer compound. 2. The oral composition according to 1, wherein the component (B) is at least one selected from calcium chloride, calcium gluconate, calcium lactate, calcium glycerophosphate, and calcium pantothenate. 3. The oral composition according to 1 or 2, wherein the component (C) is at least one selected from pyrophosphoric acid and its alkali metal salts. 4. The oral composition according to any one of 1 to 3, wherein the viscosity of a 2 mass% aqueous solution of the component (E) at 25°C is 400 mPa·s or more. 5. The oral composition according to any one of 1 to 4, wherein the component (E) is at least one selected from sodium polyacrylate, xanthan gum, sodium carboxymethyl cellulose, sodium alginate, carrageenan, hydroxyethyl cellulose, and polyvinyl pyrrolidone. 6. The oral composition according to 5, wherein the component (E) is at least one selected from sodium polyacrylate, xanthan gum, sodium carboxymethyl cellulose, hydroxyethyl cellulose, and polyvinyl pyrrolidone. 7. The oral composition according to any one of 1 to 6, wherein the mixing ratio of the component (B) and the component (D) represented by (D) / (B) is 0.0005 to 1.2 in molar ratio. 8. The oral composition according to any one of 1 to 7, wherein the mixing ratio of the component (D) and the component (E) represented by (E) / (D) is 0.5 to 200 in mass ratio.

Advantages of the Invention

[0009] According to the present invention, there can be provided an oral composition excellent in the retention of fluoride ions (F - ) on the tooth surface, suppressing the decrease in bactericidal power even after storage, and excellent in the storage stability of the skin appearance (muscle tone).

Embodiments for Carrying Out the Invention

[0010] Hereinafter, the present invention will be described in detail. The present invention is (A) Sodium fluoride, (B) Water-soluble calcium salt, (C) Condensed phosphoric acid or its salt, (D) At least one selected from cetylpyridinium chloride, benzalkonium chloride, and chlorhexidine hydrochloride, and (E) Water-soluble polymer compound and is an oral composition containing the same.

[0011] [Component (A)] Component (A) of the present invention is sodium fluoride, which is a source of fluoride ions. The blending amount of component (A) is preferably 0.09 to 1.3% (mass%, the same hereinafter) of the whole composition, and more preferably 0.10 to 1.1%. By setting it to 0.09% or more, the retention of fluoride ions (F - ) on the tooth surface is further improved. If it exceeds 1.3%, the storage stability such as solidification, liquid separation, and muscle kneading (hereinafter, may be only described as storage stability) may deteriorate.

[0012] [Component (B)] Component (B) of the present invention is a water-soluble calcium salt and can be used alone or in combination of two or more. Examples of the water-soluble calcium salt include calcium chloride, calcium gluconate, calcium lactate, calcium glycerophosphate, and calcium pantothenate. Among them, calcium chloride, calcium gluconate, calcium lactate, and calcium glycerophosphate are preferred.

[0013] The blending amount of component (B) is preferably 0.02 to 5% of the whole composition, and more preferably 0.03 to 3.0%. By setting it within the above range, the retention of fluoride ions (F - ) on the tooth surface and the bactericidal power after storage are further improved. Also, by setting it to 5% or less, the storage stability is further improved.

[0014] [Component (C)] Component (C) of the present invention is a condensed phosphoric acid or a salt thereof, and can be used alone or in combination of two or more. Examples of the condensed phosphoric acid include linear polyphosphoric acids such as pyrophosphoric acid, tripolyphosphoric acid, and tetrapolyphosphoric acid, and cyclic polyphosphoric acids such as metaphosphoric acid and tetrametaphosphoric acid. Examples of the salt include sodium salts and potassium salts. Among them, pyrophosphoric acid, tripolyphosphoric acid, metaphosphoric acid, and their salts are preferred. In particular, sodium pyrophosphate, potassium pyrophosphate, sodium tripolyphosphate, and potassium tripolyphosphate, which are linear polyphosphate salts, are preferred. Sodium pyrophosphate, potassium pyrophosphate, and sodium tripolyphosphate are more preferred. Sodium pyrophosphate and potassium pyrophosphate, which are pyrophosphoric acid and its alkali metal salts, are even more preferred.

[0015] The blending amount of component (C) is preferably 0.02 to 3.0% of the whole composition, and more preferably 0.03 to 1.3%. By setting it to 0.02% or more, the retention of fluoride ions (F - ) on the tooth surface and the bactericidal power after storage are further improved. Also, by setting it to 3.0% or less, the decrease in bactericidal power after storage is more suppressed.

[0016] [Component (D)] Component (D) of the present invention is one or more selected from cetylpyridinium chloride, benzalkonium chloride, and chlorhexidine hydrochloride, and two of them may be used in combination. These are components known as cationic bactericides. By using these components, the retention of fluoride ions (F - ) on the tooth surface is excellent, and the decrease in bactericidal power after storage is suppressed. For example, when benzethonium chloride other than the above is blended, the retention of fluoride ions (F - ) on the tooth surface becomes insufficient (Comparative Example 5). Among them, cetylpyridinium chloride, benzalkonium chloride, and chlorhexidine hydrochloride are preferred, and cetylpyridinium chloride and benzalkonium chloride are more preferred.

[0017] (D) The blending amount is preferably 0.004 to 0.2% of the whole composition, more preferably 0.005 to 0.1%. By setting it at 0.004% or more, the decrease in bactericidal power after storage is more sufficiently suppressed. By setting it at 0.2% or less, the decrease in bactericidal power after storage is more suppressed and the storage stability is more improved.

[0018] [Component (E)] Component (E) of the present invention is a water-soluble polymer compound, which can be used alone or in combination of two or more kinds. It improves the retention of fluoride ions on the tooth surface, suppresses the decrease in bactericidal power after storage, and improves the storage stability. Examples of component (E) include sodium polyacrylate, xanthan gum, sodium carboxymethyl cellulose, sodium alginate, carrageenan, hydroxyethyl cellulose, and polyvinyl pyrrolidone. Among them, sodium polyacrylate, xanthan gum, sodium carboxymethyl cellulose, hydroxyethyl cellulose, and polyvinyl pyrrolidone are preferable.

[0019] The viscosity of a 2% by mass aqueous solution of component (E) at 25°C is preferably 400 mPa·s or more, more preferably 400 to 150,000 mPa·s, and even more preferably 400 to 100,000 mPa·s. The viscosity was measured using a BH-type Brookfield viscometer at 20°C for a measurement time of 1 minute. The rotor No. and the rotation speed follow the following conditions. · When the viscosity of the 2% aqueous solution is 400 - 500 mPa·s: Rotor No. 1, rotation speed 20 rpm · When the viscosity of the 2% aqueous solution exceeds 500 mPa·s and is 2,000 mPa·s or less: Rotor No. 2, rotation speed 20 rpm · When the viscosity of the 2% aqueous solution exceeds 2,000 mPa·s and is 5,000 mPa·s or less: Rotor No. 3, rotation speed 20 rpm · When the viscosity of the 2% aqueous solution exceeds 5,000 mPa·s and is 10,000 mPa·s or less: Rotor No. 4, rotation speed 20 rpm · When the viscosity of the 2% aqueous solution exceeds 10,000 mPa·s and is 20,000 mPa·s or less: Rotor No. 5, rotation speed 20 rpm · When the viscosity of the 2% aqueous solution exceeds 20,000 mPa·s and is 50,000 mPa·s or less: Rotor No. 6, rotation speed 20 rpm · When the viscosity of the 2% aqueous solution exceeds 50,000 mPa·s and is 200,000 mPa·s or less: Rotor No. 7, rotation speed 20 rpm

[0020] (E) The blending amount of the component is preferably 0.05 to 3.0% of the whole composition, more preferably 0.06 to 2.8%, and still more preferably 0.1 to 2.0%. By setting it to 0.05% or more, the decrease in bactericidal power after storage is more suppressed and the storage stability is more improved. On the other hand, if it exceeds 3.0%, there is a risk that the extrudability will deteriorate due to an increase in the viscosity of the preparation.

[0021] In the present invention, it is more preferable that the blending ratio of the (B) component and the (D) component is within an appropriate range, and the blending ratio of the (B) component and the (D) component, represented by (D) / (B), is preferably 0.0005 to 1.2 in molar ratio, more preferably 0.0010 to 0.4, and still more preferably 0.0020 to 0.21. By setting it within this range, the retention of fluoride ions (F - ) on the tooth surface is more improved, and the decrease in bactericidal power after storage is more suppressed.

[0022] In the present invention, it is more preferable that the blending ratio of the (D) component and the (E) component is within an appropriate range, and the blending ratio of the (D) component and the (E) component, represented by (E) / (D), is preferably 0.5 to 200 in mass ratio, more preferably 2 to 150, and still more preferably 5 to 140. By setting it within this range, the retention of fluoride ions (F - ) on the tooth surface is more improved, and the decrease in bactericidal power after storage is more suppressed.

[0023] [Oral composition] The oral composition of the present invention can be in the form of solids, solids, liquids, liquids, gels, pastes, gums, etc., and can be made into various dosage forms such as toothpastes, liquid toothpastes, liquid dentifrices, and lubricating dentifrices, mouthwashes, mouthwashes, troches, chewing gums, etc. The manufacturing method can also adopt a conventional method according to the dosage form. Among them, toothpaste is preferred, and paste toothpaste is preferred. It should be noted that the present invention is not a composition in which two agents are mixed and used during use, but an oral composition in which components (A) to (E) are formulated in one composition.

[0024] The optional components are not particularly limited, and components used in oral compositions can be formulated within a range and amount that do not impair the effects of the present invention. For example, surfactants, thickeners (humectants), binders, sweeteners, coloring agents, fragrances, active ingredients, pH adjusters, solvents, etc. other than components (A) to (E) can be mentioned.

[0025] As optional surfactants, anionic surfactants, nonionic surfactants, and amphoteric surfactants can be formulated. Examples of anionic surfactants include alkyl sulfates such as sodium lauryl sulfate, acyl sarcosinates, acyl taurates, and acyl amino acid salts. Examples of nonionic surfactants include sugar fatty acid esters such as sucrose fatty acid esters, sugar alcohol fatty acid esters, sorbitan fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil, polyoxyethylene higher alcohol ethers, and fatty acid alkanolamides. Examples of amphoteric surfactants include betaine acetates such as alkyl betaines and fatty acid amide propyl betaines, and imidazolinium betaines (alkyl imidazoles) such as alkyl imidazolinium betaines and 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaines.

[0026] When formulating a surfactant, the amount thereof is preferably 0.001 to 10% of the whole composition, and more preferably 0.1 to 8%.

[0027] Examples of the thickening agent (wetting agent) include sugar alcohols such as sorbitol and xylitol, and polyhydric alcohols such as glycerin and propylene glycol. When the wetting agent is blended, the blending amount is preferably 10 to 90% of the whole composition, more preferably 12 to 85%, and still more preferably 15 to 80%.

[0028] Examples of the binder include inorganic binders such as gelling (thickening) silica and gelling (thickening) aluminum silica. When the binder is blended, the amount is preferably 0.1 to 10% of the whole composition, and more preferably 0.5 to 8%.

[0029] Examples of the sweetener include saccharin, sodium saccharin, sucralose, stevioside, aspartame, sucrose, fructose and the like.

[0030] Examples of the coloring agent include highly safe water-soluble pigments such as Food Blue No. 1, Green No. 3, Yellow No. 4, and Red No. 105.

[0031] Examples of the fragrance include natural essential oils such as peppermint oil, spearmint oil, eucalyptus oil, wintergreen oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, marjoram oil, lemon oil, nutmeg oil, lavender oil, and para-cresol oil, and fragrance components contained in the above natural essential oils such as L-menthol, carvone, cinnamic aldehyde, orange oil, anethole, 1,8-cineole, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, citral, camphor, borneol, pinene, and spirantol. Further examples include blended flavors such as apple, banana, strawberry, blueberry, melon, peach, pineapple, grape, muscat, wine, cherry, squash, coffee, brandy, and yogurt, which are formed by combining several fragrance components and natural essential oils. When blending the fragrance, the amount is preferably 0.00001 to 3% of the total composition.

[0032] The active ingredients are those known to be commonly formulated in oral compositions, such as nonionic bactericides like isopropylmethylphenol, tranexamic acid, epsilon-aminocaproic acid, allantoin, anti-inflammatory agents like glycyrrhetinic acid and glycyrrhizic acid, enzymes such as dextranase, mutanase, amylase, protease, and lysozyme, copper compounds like copper gluconate and sodium copper chlorophyllin, inorganic salts such as sodium chloride, potassium nitrate, aluminum lactate, zinc chloride, zinc citrate, and strontium chloride, vitamins such as ascorbic acid, tocopherol acetate, and pyridoxine, plant extracts such as zeolite, azulene, dihydrocholesterol, chlorophyll, peppermint soft extract, thyme, saffron, star anise, and witch hazel, tartar inhibitors, and plaque inhibitors. Note that the above active ingredients can be formulated in an effective amount as long as they do not interfere with the effects of the present invention.

[0033] pH adjusters include phthalic acid, phosphoric acid, citric acid, succinic acid, acetic acid, fumaric acid, malic acid, carbonic acid, and salts such as their potassium salts, sodium salts, and ammonium salts, and sodium hydroxide. The oral composition of the present invention preferably adjusts the pH at 25°C to 5.5 - 9.0, and a combination of citric acid and sodium citrate is preferably used as the pH adjuster in this range. A combination of citric acid and sodium citrate is preferably used as the buffering agent.

[0034] Lower monohydric alcohols having 1 - 3 carbon atoms such as water (the balance) and ethanol may be formulated.

[0035] When used as a dentifrice, an abrasive can be formulated. Examples of abrasives include silica-based abrasives such as anhydrous silicic acid, precipitated silica, aluminosilicate, and zirconosilicate, calcium phosphate-based compounds such as dicalcium phosphate dihydrate or anhydrate, calcium carbonate, and synthetic resin-based abrasives. The amount of the abrasive when formulated is preferably 2 - 50%, more preferably 5 - 30%.

[0036] The method for producing the oral composition of the present invention is not particularly limited, and it can be produced by a known method according to the dosage form. For example, the components (A) to (E), water, and optional components can be blended and produced by an ordinary method. The oral composition of the present invention is contained in a general known container according to the dosage form.

Examples

[0037] Hereinafter, examples and comparative examples will be shown to specifically explain the present invention, but the present invention is not limited to the following examples. In the following examples, unless otherwise specified, "%" of the composition is mass%, and the amounts of the respective components in the table are the amounts in terms of pure components (excluding "sorbitol solution (70%), coconut oil amide propyl betaine solution (30%)").

[0038] [Examples, Comparative Examples] Oral compositions (toothpaste compositions) having the compositions shown in Tables 1 to 6 were prepared by a conventional method and evaluated by the following method. The results are also shown in the table.

[0039] (1) Evaluation method for the retention of fluoride ions (F - ) The retention of fluoride ions (F - ) was evaluated by an adsorption test of fluoride ions (F - ) on the root surface. As test pieces, blocks were cut out from the root parts of bovine teeth and shaped so that dentin was exposed. A treatment surface of 5 × 5 mm was prepared at the exposed dentin site, and the area other than the treatment surface was coated with nail polish. 20 mL of the oral composition (a three-fold diluted solution with purified water) was allowed to act on the above dentin block for 3 minutes. Then, while 1 mL of potassium citrate buffer solution was allowed to act on the bovine tooth block, it was stirred for 1 minute to forcibly elute the adsorbed and retained fluoride ions (F - ). The concentration of fluoride ions (F - ) contained in the above buffer solution was measured with a fluoride ion (F - ) meter (trade name; Orion 1115000 4-Star, manufactured by Thermo Fisher Scientific Co., Ltd.), and the retained fluoride ions (F -)The concentration (ppm) was measured and evaluated according to the following criteria. [Evaluation Criteria] ◎: Fluoride ion (F - ) retention amount is 0.5 ppm or more 〇: Fluoride ion (F - ) retention amount is 0.3 ppm or more and less than 0.5 ppm △: Fluoride ion (F - ) retention amount is 0.1 ppm or more and less than 0.3 ppm ×: Fluoride ion (F - ) retention amount is less than 0.1 ppm

[0040] (2) Evaluation method for bactericidal power after storage 50 g of each oral composition was packed into 3 tubes (material: laminated tube with a diameter of 26 mm made of linear low-density polyethylene for the innermost layer, manufactured by Dai Nippon Printing Co., Ltd.). The tubes were stored at 40 °C for 1 month. Then, the oral composition returned to room temperature was evaluated by the following test. [Preparation of Bacterial Solution] Frozen stock Streptococcus mutans (S. mutans 25175) was dispersed in 4 mL of medium (TSB: Toryptic Soy Bloth medium) with a platinum loop, cultured at 37 °C under anaerobic conditions for 24 hours, then 1 mL of the culture solution was dispersed in another 4 mL of TSB medium, and cultured again at 37 °C under anaerobic conditions for 24 hours. Evaluation of the persistence of bactericidal power against hydroxyapatite (HAP) powder: 10 mg of HAP powder was weighed into each well in the first row of a 96-well plate, washed with 200 μL of 10 mM, pH 7.0 phosphate buffer (PBS), and then immersed in 200 μL of PBS overnight. [Measurement of MIC (Minimum Inhibitory Concentration)] After washing the PBS-treated HAP powder twice with 200 μL of PBS, 150 μL of sterilized saliva was added, and the well was rotated at 5 rpm for 30 minutes at room temperature with the well sealed. The saliva was removed, 100 μL of a 3-fold dilution of the oral composition (diluted with artificial saliva) was added, and after rotating for another 30 minutes, the excess sample was removed, washed three times with 200 μL of PBS, and 200 μL of PBS was added to the well containing the HAP powder and 100 μL of PBS was added to the other wells. After 1 hour, while stirring, a two-fold serial dilution including the HAP powder was performed, then 100 μL of PBS was added to each well, and further 10 μL of the bacterial solution was added. After gently stirring, the mixture was cultured at 37 °C under anaerobic conditions for 24 hours, and the MIC (minimum inhibitory concentration) was determined visually.

[0041] Regarding the oral composition before storage (initial product) and the oral composition after storage at 40 °C for 1 month (40 °C·1-month storage product), the MIC was measured for each, and the maintenance rate of the MIC of the 40 °C·1-month storage product was calculated based on the following formula. Evaluation was performed according to the following criteria based on the obtained maintenance rate. Maintenance rate of MIC of 40 °C·1-month storage product = (MIC of storage product) / (MIC of initial product) [Evaluation criteria for bactericidal power after storage] ◎: MIC maintenance rate is less than 1.1 〇: MIC maintenance rate is 1.1 or more and less than 1.15 △: MIC maintenance rate is 1.15 or more and less than 1.2 ×: MIC maintenance rate is 1.2 or more

[0042] (3) Evaluation method for storage stability (texture) Each oral composition was filled into three tube containers (material: a laminated tube with a diameter of 26 mm made of linear low-density polyethylene for the innermost layer (manufactured by Dai Nippon Printing Co., Ltd.)) at 50 g each and stored at 40 °C for 1 month. After storage, the dentifrice composition was extruded onto paper from each tube container, and the state of the texture appearance was evaluated according to the following scoring criteria. The average score of the three was obtained, and the texture appearance stability of the oral composition was evaluated according to the following evaluation criteria. [Scoring criteria] 4 points: There are no wrinkles on the surface of the oral composition, the surface has luster, and there are no quality problems. 3 points: There are slight wrinkles on the surface of the oral composition, and the gloss of the surface is slightly weak, but it is at a level with no quality problems. 2 points: Wrinkles are observed on the surface of the oral composition, there is no gloss on the surface, and it is at a level with quality problems. 1 point: Obvious wrinkles are observed on the surface of the oral composition, there is no gloss on the surface, and it is at a level with quality problems. [Evaluation Criteria] ◎: The average score is 4.0 points 〇: The average score is 3.0 points or more and less than 4.0 points △: The average score is 2.0 points or more and less than 3.0 points ×: The average score is less than 2.0 points

[0043]

Table 1

[0044]

Table 2

[0045]

Table 3

[0046]

Table 4

[0047]

Table 5

[0048]

Table 6

[0049] The raw materials used in the above examples are shown below. Unless otherwise specified, the amounts of each component in the table are in terms of pure component conversion. Sodium fluoride: manufactured by Stella Chemifa Corporation Calcium chloride: manufactured by Tomita Pharmaceutical Co., Ltd. Calcium gluconate: manufactured by Fuso Chemical Industry Co., Ltd. Calcium lactate hydrate: manufactured by Taihei Chemical Industry Co., Ltd., trade name "Calcium Lactate" Calcium glycerophosphate: manufactured by Iwaki Seika Co., Ltd. Calcium pantothenate: manufactured by BASF Tetrapotassium pyrophosphate: manufactured by Taihei Chemical Industry Co., Ltd. Sodium pyrophosphate: manufactured by Taihei Chemical Industry Co., Ltd., trade name "Sodium Pyrophosphate (Anhydrous)" Sodium tripolyphosphate: manufactured by Taihei Chemical Industry Co., Ltd. Cetylpyridinium chloride: manufactured by Fujifilm Wako Pure Chemical Corporation Benzalkonium chloride: manufactured by NOF Corporation Sodium polyacrylate: manufactured by Toagosei Co., Ltd., trade name "Leodig 250-H" Xanthan gum: manufactured by DSP Gokyo Foods & Chemicals Co., Ltd., trade name "Monat Gum DA" Sodium carboxymethyl cellulose: manufactured by Daicel Finechem Ltd., trade name "CMC1260" Sodium alginate: manufactured by Kimica Corporation, trade name "Kimica Algine" Carrageenan: manufactured by Sankyo Co., Ltd., trade name "Carrageenan CF02" Sodium hydroxyethyl cellulose: manufactured by Daicel Finechem Ltd., trade name "SE850" Polyvinylpyrrolidone: manufactured by Sumitomo Pharma Foods & Chemicals Co., Ltd., trade name "Plasdone K-90"

Claims

1. (A) Sodium fluoride, (B) A water-soluble calcium salt, (C) Condensed phosphoric acid or its salt, (D) At least one selected from cetylpyridinium chloride, benzalkonium chloride, and chlorhexidine hydrochloride, and (E) A water-soluble polymer compound An oral composition containing the same.

2. The oral composition according to claim 1, wherein the component (B) is at least one selected from calcium chloride, calcium gluconate, calcium lactate, calcium glycerophosphate, and calcium pantothenate.

3. The oral composition according to claim 1 or 2, wherein the component (C) is at least one selected from pyrophosphoric acid and its alkali metal salts.

4. The oral composition according to claim 1 or 2, wherein the viscosity of a 2% by mass aqueous solution of the component (E) at 25°C is 400 mPa·s or more.

5. The oral composition according to claim 1 or 2, wherein the component (E) is at least one selected from sodium polyacrylate, xanthan gum, sodium carboxymethyl cellulose, sodium alginate, carrageenan, hydroxyethyl cellulose, and polyvinyl pyrrolidone.

6. The oral composition according to claim 5, wherein the component (E) is at least one selected from sodium polyacrylate, xanthan gum, sodium carboxymethyl cellulose, hydroxyethyl cellulose, and polyvinyl pyrrolidone.

7. The oral composition according to claim 1 or 2, wherein the mixing ratio of the component (B) and the component (D), represented by (D) / (B), is 0.0005 to 1.2 in molar ratio.

8. The oral composition according to claim 1 or 2, wherein the mixing ratio of the component (D) and the component (E), represented by (E) / (D), is 0.5 to 200 in mass ratio.

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