Lymph vessel neogenesis induction device

Abstract

To provide a lymph vessel neogenesis induction device that enables radical treatment without requiring a difficult technique.SOLUTION: Provided is a lymph vessel neogenesis induction device 10 including: a puncture member 12 including a distal end portion 16 capable of puncturing a biological tissue and a through hole 18 penetrating and extending along a central axis C from the distal end portion 16 toward a proximal end; and a rod-like body 14 inserted to the through hole 18 and capable of projecting from the distal end portion 16. The rod-like body 14 includes: a shaft part 21; and an injury imparting structure 20 including a plurality of randomly provided projection parts 22 that are provided in the shaft part 21 and imparts the biological tissue 122 with an injury 126.SELECTED DRAWING: Figure 2

Description

Technical Field

[0001] The present invention relates to a lymphangiogenesis induction device used in a technique for inducing lymphangiogenesis.

Background Art

[0002] There is a lymphatic vessel as one of the routes for collecting tissue fluid in the living body. When the lymphatic vessel is blocked, the tissue fluid may stagnate and lymphedema may develop, which is accompanied by functional decline such as swelling and sensory paralysis of the limbs such as the arms and legs. Lymphedema is said to often occur due to lymph node dissection and radiotherapy performed as part of cancer treatment such as breast cancer treatment.

[0003] Lymphedema is a disease that is difficult to completely cure once it develops. If it becomes chronic, it is difficult to improve easily, and if left untreated, it is said to become more severe.

[0004] Currently, the first choice for the treatment of lymphedema is complex physical therapy (Non-Patent Document 1). Complex physical therapy is a treatment method in which compression therapy, skin care, exercise under compression, massage, etc. are appropriately combined according to the patient's condition, where compression therapy involves wrapping elastic clothing, elastic bandages, etc. around the swollen part of the body to apply compressive force (Non-Patent Document 2).

[0005] In addition, as a radical treatment method for lymphedema, there is lymphaticovenular anastomosis (LVA). Lymphaticovenular anastomosis is a technique for anastomosing an occluded lymphatic vessel and a vein (Non-Patent Document 3).

Prior Art Documents

Non-Patent Documents

[0006]

Non-Patent Document 1

Non-Patent Document 2

Non-Patent Document 3

Summary of the Invention

Problems to be Solved by the Invention

[0007] Complex physical therapy is a conservative therapy mainly aimed at delaying the progression of lymphedema and does not improve symptoms. Therefore, daily self-care including compression is required, which is a burden for patients.

[0008] Lymphovenous anastomosis is considered a radical therapy. However, lymphovenous anastomosis requires advanced plastic surgery techniques and there is a problem that the opportunity to receive treatment is limited. In addition, there are cases where suitable veins or lymphatic vessels for anastomosis cannot be found, or where thrombi occur in the anastomosed blood vessels, and sufficient effects may not be obtained. Furthermore, it is said that the quality of anastomosis affects the results, and a unified technique has not been established. For this reason, the 2018 edition of the Lymphedema Treatment Guidelines (Non-Patent Document 1) only states that it is worth considering for patients who cannot be compressed.

[0009] Therefore, an object is to provide a lymphangiogenesis induction device that enables radical treatment without requiring difficult techniques.

Means for Solving the Problems

[0010] One aspect of the following disclosure is a lymphangiogenesis induction device having a puncturing member with a tip capable of puncturing biological tissue and a through-hole extending through the tip along a central axis toward the proximal end, and a rod-shaped body inserted through the through-hole and capable of protruding from the tip, wherein the rod-shaped body has a shaft portion and a wound-imparting structure including a plurality of protrusions provided to protrude outward from the shaft portion and imparting a wound along a path bypassing an occlusion site of a lymphatic vessel in the biological tissue, and the protrusions are provided in a plurality at random axial and circumferential positions of the shaft portion.

Advantages of the Invention

[0011] According to the lymphangiogenesis induction device of the above aspect, radical treatment can be performed without requiring difficult techniques.

Brief Description of the Drawings

[0012]

Figure 1

Figure 2

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Figure 10

Embodiments for Carrying Out the Invention

[0013] Hereinafter, preferred embodiments of the lymphangiogenesis induction device of the present invention will be given and described in detail with reference to the accompanying drawings.

[0014] (First Embodiment) The lymphatic vessel tissue 100 of normal skin 101 and deep tissue 118 has a structure as shown in FIG. 1A. The lymphatic vessel tissue 100 starts from the lymphatic capillary 102. The lymphatic capillary 102 has a diameter of 20 to 70 μm and is reticulated in the dermis 106 directly under the epidermis 104. The lymphatic capillary 102 migrates to the pre-collecting lymphatic vessel 108 existing inside the dermis 106. The pre-collecting lymphatic vessel 108 has a diameter of 70 to 150 μm and has a valve structure for flowing lymph fluid from the distal end to the proximal end, and is distributed at a position deeper than the lymphatic capillary 102.

[0015] The pre-collecting lymphatic vessel 108 migrates into the collecting lymphatic vessel 110. The collecting lymphatic vessel 110 is abundant in the subcutaneous tissue 114, and its diameter is about 0.3 mm in the upper limb and trunk, and about 0.5 mm in the lower limb. The collecting lymphatic vessel 110 has smooth muscle around it, and the smooth muscle performs automatic movement, so it has the function of guiding lymph fluid in the central direction. The collecting lymphatic vessel 110 is composed of a superficial collecting duct 116 in the subcutaneous tissue 114 and a deep collecting duct 120 in the deep tissue 118. The superficial collecting duct 116 and the deep collecting duct 120 are connected to a lymph node (not shown) on the central side and finally connected to a vein.

[0016] Lymphedema is considered to be caused by the dysfunction of the collecting lymphatic vessel 110. As shown in FIG. 1B, although not particularly limited, lymphedema is mainly considered to be caused by the occurrence of an occlusion site 116a in the superficial collecting duct 116. At such an occlusion site 116a, the wall of the collecting lymphatic vessel 110 thickens and hypertrophies, and the flow path becomes narrow or blocked. When the collecting lymphatic vessel 110 is blocked in this way, the tissue fluid cannot be discharged, and the limbs swell to develop lymphedema.

[0017] The lymphangiogenesis induction device 10 of the present embodiment shown in FIG. 2 is used to newly form a lymphatic vessel that serves as a detour for the lymphatic vessel tissue 100 in which the above-mentioned occlusion site 116a (see FIG. 1B) has occurred.

[0018] As shown in the figure, the lymphangiogenesis induction device 10 has a puncture member 12 and a rod-shaped body 14. The puncture member 12 is a long cylindrical member and has a gripping portion (not shown) on the proximal end side. The gripping portion is a cylindrical member such as a catheter hub, and an operator such as a doctor can operate the puncture member 12 by holding the gripping portion.

[0019] At the tip of the puncture member 12, a tip portion 16 capable of puncturing the living tissue 122 is formed. The tip portion 16 has, for example, an inclined surface 16a notched obliquely with respect to the central axis C of the puncture member 12 as shown in the figure, and a sharp needle tip 16b formed at the tip of the inclined surface 16a. Note that the tip portion 16 may be a blunt needle in which the needle tip 16b is processed to be blunt.

[0020] Inside the puncturing member 12, a through-hole 18 is formed along the central axis C. The through-hole 18 is formed so as to penetrate from the tip end to the base end of the puncturing member 12. The tip end of the through-hole 18 opens at the opening 18a of the inclined surface 16a. The base end of the through-hole 18 opens on the gripping portion side. The puncturing member 12 and the through-hole 18 are formed in a circular shape centered on the central axis C in a cross-section perpendicular to the central axis C. Note that the cross-sectional shapes of the puncturing member 12 and the through-hole 18 are not limited to circular, and may be rectangular or polygonal.

[0021] The puncturing member 12 can be formed of, for example, a metal material such as stainless steel, aluminum or an aluminum alloy, titanium or a titanium alloy, a nickel-titanium alloy, a hard resin, ceramics, or the like. The outer diameter of the puncturing member 12 is, for example, about 0.5 to 3.0 mm, and the inner diameter of the through-hole 18 can be 0.25 to 2.5 mm.

[0022] The rod-shaped body 14 is a member having a length approximately equal to or longer than the entire length of the puncturing member 12, and is formed to have a size that can be inserted into the through-hole 18 of the puncturing member 12. The base end side of the rod-shaped body 14 protrudes toward the gripping portion side of the puncturing member 12. An operator such as a doctor can perform an operation of gripping the base end side of the rod-shaped body 14 and moving the rod-shaped body 14 forward and backward in the axial direction.

[0023] The rod-shaped body 14 is provided with a wound-imparting structure 20 in a part near the tip end. In the present embodiment, the wound-imparting structure 20 has a shaft portion 21 configured as a part on the tip end side of the rod-shaped body 14, and a plurality of protruding portions 22 protruding outward from the shaft portion 21. The protruding portions 22 are formed to protrude outward from the side portion of the shaft portion 21, and are arranged at intervals from each other over the entire circumferential direction of the shaft portion 21. The tip ends of the protruding portions 22 are formed to be sharp and are formed in a shape capable of wounding the biological tissue 122. The protruding portions 22 may be integrally formed with the rod-shaped body 14. The shaft portion 21 is formed to have a diameter of about 0.2 to 2.0 mm, and the protruding height of the protruding portions 22 from the shaft portion 21 can be about 0.1 to 0.5 mm on average.

[0024] The protrusions 22 in FIG. 2 are shown as a plurality of protrusions randomly arranged on the outer peripheral portion of the rod-shaped body 14, but are not limited thereto, and may be formed in a spiral shape on the outer peripheral portion of the rod-shaped body 14. Further, it may be formed to protrude in a disk shape along the circumferential direction of the rod-shaped body 14. Note that some of the collecting lymphatic vessels 110 extend along nerve bundles, blood vessels, etc., and if the wound-providing structure 20 is too thick, there is a risk of damaging the nerve bundles and blood vessels. In order to prevent such an event, the outer diameter of the wound-providing structure 20 (the outer diameter of the rod-shaped member including the protrusions 22) is preferably 6.0 mm or less.

[0025] The outer diameter of the rod-shaped body 14 including the protrusions 22 is formed smaller than the inner diameter of the through-hole 18 of the puncturing member 12, and the rod-shaped body 14 can smoothly advance or retreat within the through-hole 18. The rod-shaped body 14 including the protrusions 22 may be made of any material as long as it has a strength capable of piercing into the body and has hardness and toughness resistant to rubbing against the biological tissue 122. Although not particularly limited, the rod-shaped body 14 and the wound-providing structure 20 can be made of, for example, metal materials such as stainless steel, aluminum or aluminum alloy, titanium or titanium alloy, nickel-titanium alloy, hard resin, ceramics and other materials.

[0026] Note that the protrusions 22 may be formed by joining a separately formed rod-shaped body 14 to the outer peripheral surface of the rod-shaped body 14. In this case, only the protrusions 22 may be made of a material having high hardness.

[0027] The lymphangiogenesis induction device 10 of the present embodiment is configured as described above, and its operation will be described below together with a technique for inducing lymphangiogenesis (a method for treating lymphedema).

[0028] As shown in FIG. 3, in the procedure for inducing lymphangiogenesis, first, the lymphatic injury area is confirmed (step S10). The confirmation of the lymphatic injury area can be performed by methods such as ICG fluorescence lymphangiography, lymphoscintigraphy, MRI, CT, and ultrasonic imaging diagnosis. ICG fluorescence lymphangiography is a method of confirming lymphatic vessels by injecting ICG (indocyanine green) between the fingers of the affected limb with lymphedema and observing the flow of lymph fluid in the skin 101 and its surroundings with a near-infrared camera. Lymphoscintigraphy is a method of confirming lymphatic vessels by injecting a chemical solution containing a radioactive substance such as technetium into the fingers of the limb and then imaging the flow of lymph fluid with a gamma camera.

[0029] Next, the regeneration route of the lymphatic vessels is confirmed (step S20). Here, an occluded lymphatic vessel (for example, the collecting lymphatic vessel 110) is identified, and a path 124 connecting that lymphatic vessel and the adjacent lymphatic vessel is determined. For example, in the case of FIG. 4, a path 124 that bypasses the occlusion site 116a of the collecting lymphatic vessel 110 is determined.

[0030] Next, as shown in step S30 of FIG. 3, the lymphangiogenesis induction device 10 is punctured into the biological tissue 122. As shown in FIG. 5, the lymphangiogenesis induction device 10 punctures while the rod-shaped body 14 is housed inside the through-hole 18 of the puncturing member 12. Then, the lymphangiogenesis induction device 10 is advanced so as to pass through the portion of the path 124 in FIG. 4.

[0031] Next, as shown in step S40 of FIG. 3, the puncturing member 12 is pulled out from the biological tissue 122. As a result, as shown in FIG. 6, the rod-shaped body 14 remains in the biological tissue 122.

[0032] Next, as shown in step S50 of FIG. 3, the rod-shaped body 14 is pulled out from the biological tissue 122. As shown in FIG. 6, when the rod-shaped body 14 is pulled out, the tip of the protrusion 22 is punctured into the biological tissue 122, and a fine wound 126 is formed in the biological tissue 122. By pulling out the rod-shaped body 14, a wound 126 is formed along the path 124 in FIG. 4. Note that steps S40 and S50 in FIG. 3 are not limited to being performed separately in the order shown in the figure. For example, an operation of slightly pulling out the puncturing member 12 (step S40) and an operation of slightly pulling out the remaining rod-shaped body 14 from the biological tissue 122 (step S50) may be alternately repeated to form a fine wound 126 in the biological tissue 122. Also, instead of pulling out the puncturing member 12 from the biological tissue 122 at once, the puncturing member 12 may be pulled out little by little together with the rod-shaped body 14 while maintaining the state where the rod-shaped body 14 protrudes.

[0033] Thus, the procedure for one path 124 is completed. For other paths 124, by repeating the operations of steps S10 to S50, wounds 126 are formed for all paths 124, and the procedure using the lymphangiogenesis induction device 10 is completed.

[0034] As shown in FIG. 7A, in the process of healing of the wound 126 along the path 124, immune cells accumulate in the wound 126 due to the immune response to the wound 126. It has been found that the expression of lymphangiogenic growth factors is enhanced as part of the immune response by various immune cells (Tiina P. Viitane et al., Plast Reconstr Surg Glob Open. 2013 May;1(2):1-9). Therefore, lymphangiogenesis is induced in the portion where the wound 126 is formed by the lymphangiogenesis induction device 10 of the present embodiment.

[0035] Lymphangiogenesis occurs by budding from existing lymphatic vessels (Tammela & Alitalo, Cell. 2010 Feb 19;140(4):460 - 476.). Therefore, in the case of wound 126 in Fig. 7A, the superficial collecting duct 116A is newly formed so as to extend from the existing lymphatic vessel. In this way, as shown in Fig. 7B, a new superficial collecting duct 116A (collecting lymphatic vessel 110) is newly formed as a detour. Note that the collecting lymphatic vessel 110 newly formed by the lymphangiogenesis induction device 10 of the present embodiment may be a collecting lymphatic vessel 110A that connects the superficial collecting duct 116 and the deep collecting duct 120, as shown in Fig. 8. Also, the puncture / operation site of the lymphangiogenesis induction device 10 is not limited to the subcutaneous tissue. It is also possible to newly form a new deep collecting duct 120 that connects the deep collecting ducts 120 to each other. Furthermore, the lymphangiogenesis induction device 10 may newly form lymphatic capillaries 102 and pre - collecting lymphatic vessels 108. It has been reported that the lymphatic capillaries 102 and pre - collecting lymphatic vessels 108 can also prevent the onset of lymphedema by functioning as a detour through the collecting lymphatic vessel 110 (Suami et.al., Plastic and Reconstructive Surgery, vol.120, No.4, pp982 - 991, Sept 15, 2007).

[0036] (Modification example) The operation using the lymphangiogenesis induction device 10 of the present embodiment is not limited to the example described with reference to Figs. 3 - 6. As shown in Fig. 9A, in this modification example, a protrusion 23 protruding axially is formed at the tip of the rod - shaped body 14. The tip of the protrusion 23 is formed sharply. Since the tip of the protrusion 23 is sharp, it can create a wound in the biological tissue 122 torn by its tip. Also, an edge may be formed at the boundary between the inclined surface of the protrusion 23 and the side wall of the rod - shaped body 14 on the proximal end side of the protrusion 23. Such an edge can contribute to the generation of a wound.

[0037] In the lymphangiogenesis induction device 10 according to this modification example, with the rod-shaped body 14 housed inside the through-hole 18 of the puncture member 12, the puncture member 12 is punctured near the target site. Then, as shown in FIG. 9B, an operation is performed to project the rod-shaped body 14 from the tip of the puncture member 12 toward the biological tissue 122. As a result, the protruding portion 23 of the rod-shaped body 14 is punctured into the biological tissue 122, and the rod-shaped body 14 forms a wound 126 at the passing portion thereof. The protruding portion 23 at the tip of the rod-shaped body 14 may have a sharp shape that can be punctured into the biological tissue 122 using only the rod-shaped body 14 without using the puncture member 12.

[0038] The lymphangiogenesis induction device 10 of the present embodiment has the following effects.

[0039] The lymphangiogenesis induction device 10 of the present embodiment includes a puncture member 12 having a tip portion 16 that can puncture a biological tissue 122 and a through-hole 18 that penetrates and extends along the central axis C from the tip portion 16 toward the base end, and a rod-shaped body 14 inserted through the through-hole 18 and capable of protruding from the tip portion 16. The rod-shaped body 14 has a shaft portion 21 and a wound-imparting structure 20 including at least one protruding portion 22 provided on the shaft portion 21 and imparting a fine wound 126 to the biological tissue 122.

[0040] According to the above configuration, by having the wound-imparting structure 20, a fine wound 126 can be efficiently formed along the puncture path 124 of the puncture member 12. The formation of this wound 126 promotes the generation of lymphatic vessels, and thus it is possible to promote the generation of new lymphatic vessels (capillary lymphatic vessels 102, pre-collecting lymphatic vessels 108, or collecting lymphatic vessels 110) so as to bypass the blocked or narrowed collecting lymphatic vessel 110.

[0041] In the above-described lymphangiogenesis induction device 10, the wound-imparting structure 20 may have a plurality of protrusions 22 protruding outward from the shaft portion 21. According to this configuration, when the rod-shaped body 14 is pulled out, the plurality of protrusions 22 are punctured into the biological tissue 122 and move while tearing the biological tissue 122, so that fine wounds 126 can be efficiently formed. In addition, since the protrusions 22 can form the wounds 126 in a range larger than the diameter of the rod-shaped body 14, a more active inflammatory reaction can be induced.

[0042] In the above-described lymphangiogenesis induction device 10, the protrusions 22 may be provided at different axial positions and different circumferential positions of the shaft portion 21. According to this configuration, fine wounds 126 can be efficiently formed in the biological tissue 122.

[0043] In the above-described lymphangiogenesis induction device 10, the protrusions 22 may have the same protruding height from the shaft portion 21 in a state of being housed in the through-hole 18 and in a state of protruding from the tip portion 16. According to this configuration, the structure of the protrusions 22 can be simplified.

[0044] In the above-described lymphangiogenesis induction device 10, the protrusions 22 may be spiral protrusions. Even with this configuration, fine wounds 126 can be efficiently formed in the biological tissue 122.

[0045] In the above-described lymphangiogenesis induction device 10, the wound-imparting structure 20 may be capable of repeating protrusion from the tip portion 16 of the puncturing member 12 and retraction into the through-hole 18. Thereby, an operator such as a doctor can operate the rod-shaped body 14 more finely, and can control more finely the position where the wound 126 is formed.

[0046] According to another aspect of the present embodiment, a treatment method using a lymphangiogenesis induction device 10 having a puncturing member 12 provided at its tip with a tip portion 16 that can puncture a biological tissue 122, and a through hole 18 that penetrates and extends along a central axis C from the tip portion 16 toward the base end, and a rod-shaped body 14 that is inserted through the through hole 18 and can protrude from the tip portion 16, the rod-shaped body 14 having a wound-imparting structure 20 that imparts a fine wound 126 to the biological tissue 122, the method including: a step S30 of puncturing the puncturing member 12 along the regeneration route of lymphatic vessels in the biological tissue 122; a step S40 of pulling out the puncturing member 12 from the biological tissue 122 leaving the rod-shaped body 14; and a step S50 of pulling out the rod-shaped body 14 from the biological tissue 122.

[0047] According to the treatment method of the above aspect, a fine wound 126 can be generated by the wound-imparting structure 20 along the regeneration route of lymphatic vessels. As a result, immune cells accumulate in the wound 126 along the regeneration route of lymphatic vessels, and as part of the immune response by various immune cells, the expression of lymphangiogenesis factors is enhanced, thereby promoting the regeneration of lymphatic vessels.

[0048] (Second Embodiment) As shown in FIG. 10A, the lymphangiogenesis induction device 10A of the present embodiment is different from the lymphangiogenesis induction device 10 of FIG. 2 in the rod-shaped body 14A. In the lymphangiogenesis induction device 10A of the present embodiment, the same components as those of the lymphangiogenesis induction device 10 of FIG. 2 are denoted by the same reference numerals, and detailed description thereof is omitted.

[0049] As shown in the figure, the rod-shaped body 14A has a wound-imparting structure 20A near its tip. The wound-imparting structure 20A of the present embodiment has a plurality of protruding portions 22A that protrude outward from the side portion of the shaft portion 21 of the rod-shaped body 14A. The protruding portion 22A of the present embodiment has a folding mechanism 24 that can be deformed such that the outer end portion bends toward the proximal end side of the rod-shaped body 14A. The folding mechanism 24 of the protruding portion 22A shown in the figure is constituted by the elastic deformation of the protruding portion 22A. Further, the folding mechanism 24 of the protruding portion 22A is not limited to the elastic deformation of the protruding portion 22A, and may be constituted by a hinge structure provided near the base of the protruding portion 22A on the rod-shaped body 14A.

[0050] When the rod-shaped body 14A is in a state of being housed inside the through hole 18 of the puncturing member 12, the protruding portions 22A are folded, and the size is such that it can be inserted through the inside of the through hole 18.

[0051] On the other hand, when the rod-shaped body 14A is protruded from the tip portion 16 of the puncturing member 12, as shown in FIG. 10B, the protruding portions 22A are deformed into an open state by elastic restoring force and stand up. As a result, the protruding range of the protruding portions 22A expands. In the state where the protruding portions 22A are open, the protruding height of the protruding portions 22A from the rod-shaped body 14A is about 0.2 to 1.0 mm on average. Therefore, in the rod-shaped body 14A of the present embodiment, the outer diameter of the wound-imparting structure 20A is larger than the inner diameter of the through hole 18. The protruding portions 22A are configured to maintain the standing state shown in FIG. 10B even when an operation of pulling out the rod-shaped body 14A toward the proximal end side is performed on the biological tissue 122 (see FIG. 5).

[0052] Also in the lymphangiogenesis induction device 10A of the present embodiment, as shown in FIGS. 10A and 10B, an operation of forming a wound in the biological tissue 122 may be performed by protruding the rod-shaped body 14A from the tip of the puncturing member 12. In this case, in order to surely deploy the protruding portions 22A, the rod-shaped body 14A may be reciprocated a plurality of times in the front-rear direction.

[0053] The lymphangiogenesis induction device 10A of the present embodiment is configured as described above and has the following effects.

[0054] The lymphangiogenesis induction device 10A of this embodiment has a plurality of protrusions 22A on the wound-imparting structure 20A. When the protrusion 22A shifts from the state of being housed in the through-hole 18 to the state of protruding from the tip 16, the protruding height from the shaft portion 21 increases.

[0055] According to this configuration, minute wounds 126 can be created in a range larger than the inner diameter of the through-hole 18. Thereby, the puncturing member 12 can be made thinner.

[0056] In the above-described lymphangiogenesis induction device 10A, the protrusion 22A may be folded inward inside the through-hole 18 and may open outward and protrude when protruding from the tip 16. According to this configuration, a protrusion 22A that spreads wider than the inner diameter of the through-hole 18 can be realized with a simple structure.

[0057] In the above, although the preferred embodiments of the present invention have been described with examples, it goes without saying that the present invention is not limited to the above embodiments, and various modifications are possible without departing from the gist of the present invention.

Explanation of Reference Numerals

[0058] 10, 10A... Lymphangiogenesis induction device 12... Puncturing member 14, 14A... Rod-shaped body 16... Tip 18... Through-hole 20, 20A... Wound-imparting structure 21... Shaft portion 22, 22A, 23... Protrusion 122... Biological tissue 126... Wound

Claims

1. A puncturing member having a tip capable of puncturing a biological tissue and a through hole extending through along a central axis from the tip toward the proximal end, and a rod-shaped body inserted through the through hole and capable of protruding from the tip, wherein the rod-shaped body has a shaft portion and a wound-imparting structure including a plurality of protrusions provided to protrude outward from the shaft portion and imparting a wound along a path that bypasses an occlusion site of a lymphatic vessel in the biological tissue, wherein the plurality of protrusions are randomly provided at different axial positions and different circumferential positions of the shaft portion, A lymphangiogenesis induction device.

2. The lymphangiogenesis induction device according to claim 1, wherein the protrusions are formed of a material having a higher hardness than the rod-shaped body. A lymphangiogenesis induction device.

3. The lymphangiogenesis induction device according to claim 1 or 2, wherein the protrusions have the same protruding height from the shaft portion in a state of being housed in the through hole and in a state of protruding from the tip. A lymphangiogenesis induction device.

4. The lymphangiogenesis induction device according to any one of claims 1 to 3, wherein the wound-imparting structure can repeatedly protrude from the tip of the puncturing member and retract into the through hole. A lymphangiogenesis induction device.

5. A puncturing member having a tip capable of puncturing a biological tissue and a through hole extending through along a central axis from the tip toward the proximal end, and a rod-shaped body inserted through the through hole and capable of protruding from the tip, wherein the rod-shaped body has a shaft portion and a wound-imparting structure including a plurality of protrusions provided to protrude outward from the shaft portion and imparting a wound along a path that bypasses an occlusion site of a lymphatic vessel in the biological tissue, wherein the plurality of protrusions have a folding mechanism that is folded inward inside the through hole and opens and protrudes outward when protruding from the tip, wherein the folding mechanism is constituted by the plurality of protrusions that elastically deform, wherein the plurality of protrusions increase the protruding height from the shaft portion when shifting from a state of being housed in the through hole to a state of protruding from the tip, wherein the protrusions are randomly provided at different axial positions and different circumferential positions of the shaft portion, A lymphangiogenesis induction device.

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