Topical preparation for skin

Abstract

To provide a topical preparation for skin including a skin aging-preventive ingredient while having excellent usability.SOLUTION: The present invention relates to a topical preparation for skin containing the following components (A) and (B): (A) 0.2-1.0 mass% of dipotassium glycyrrhizate relative to the total topical preparation for skin; and (B) one or two or more selected from polysorbate 60 and sucrose fatty acid ester.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to an external preparation for skin, particularly a sunscreen external preparation for skin.

Background Art

[0002] It is known that aging symptoms such as wrinkles are caused by aging, ultraviolet rays, etc. Since such aging symptoms can greatly affect the impression of appearance, etc., there is a high demand for external preparations for skin such as cosmetics containing components that improve aging symptoms such as wrinkles.

[0003] Dipotassium glycyrrhizinate is known as one of the components having a wrinkle-improving effect (Patent Document 1), but cosmetics containing dipotassium glycyrrhizinate may cause a sticky feeling.

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0005] In view of such a situation, an object of the present invention is to provide an external preparation for skin that contains dipotassium glycyrrhizinate and has a suppressed sticky feeling.

Means for Solving the Problems

[0006] The present inventors conducted studies to solve the above problems, and as a result, found that an external preparation for skin that meets the above problems can be obtained by using a combination of a specific amount of dipotassium glycyrrhizinate and a specific surfactant, and completed the present invention. That is, the gist of the present invention relates to the following.

[0007] [1] The following components (A) and (B): (A) 0.2 to 1.0% by mass of dipotassium glycyrrhizinate with respect to the whole external preparation for skin, (B) one or more selected from polysorbate 60 and sucrose fatty acid esters, An external preparation for skin containing the same. [2] The external preparation for skin according to [1], wherein the sucrose fatty acid ester of component (B) contains one or more selected from sucrose laurate, sucrose myristate, sucrose palmitate, sucrose stearate, sucrose isostearate, and sucrose polystearate. [3] The external preparation for skin according to [1] or [2], wherein the sucrose fatty acid ester of component (B) contains one or more selected from sucrose polystearate, sucrose stearate, and sucrose palmitate. [4] The external preparation for skin according to any one of [1] to [3], containing 0.01 to 10% by mass of component (B) with respect to the whole external preparation for skin. [5] The external preparation for skin according to any one of [1] to [4], wherein the mass ratio ((B) / (A)) of the contents of component (A) and (B) is 0.1 to 50. [6] The external preparation for skin according to any one of [1] to [5], further containing component (C) an ultraviolet absorber. [7] The external preparation for skin according to [6], wherein the ultraviolet absorber of component (C) contains ethylhexyl methoxycinnamate and / or hexyl dimethylaminohydroxybenzoyl benzoate. Agent. [8] The external preparation for skin according to [6] or [7], containing 0.01 to 15% by mass of component (C) with respect to the whole external preparation for skin. [9] The external preparation for skin according to any one of [1] to [8], further containing (D) an ultraviolet scattering agent.

[10] The external preparation for skin according to [9], wherein the ultraviolet scattering agent of component (D) contains fine particle titanium oxide and / or fine particle zinc oxide.

[11] The external preparation for skin according to [9] or

[10] , wherein component (D) is hydrophobically treated. The topical skin preparation according to any one of [9] to

[11] , containing 0.01 to 15% by mass of component (D) with respect to the whole topical skin preparation. The topical skin preparation according to [1], which is for sunburn prevention.

[14] The following components (A) and (B): (A) Dipotassium glycyrrhizinate in an amount of 0.2 to 1.0% by mass with respect to the whole topical skin preparation, (B) One or more selected from polysorbate 60 and sucrose fatty acid esters, A method for producing a topical skin preparation, comprising a step of blending.

Advantages of the Invention

[0008] According to the present invention, it is possible to provide a topical skin preparation that contains dipotassium glycyrrhizinate as an anti-skin-aging component and yet has a suppressed sticky feeling. Further, the topical skin preparation of the present invention suppresses a creaking feeling and a dry feeling, and is also excellent in suppressing crystal precipitation.

Modes for Carrying Out the Invention

[0009] Hereinafter, the present invention will be described. <Topical Skin Preparation> One aspect of the present invention relates to a topical skin preparation (hereinafter sometimes referred to as "the topical skin preparation of the present invention") containing the following components (A) and (B). (A) Dipotassium glycyrrhizinate in an amount of 0.2 to 1.0% by mass with respect to the whole topical skin preparation, (B) One or more selected from polysorbate 60 and sucrose fatty acid esters.

[0010] The present inventors conducted various studies to obtain a topical skin preparation that contains dipotassium glycyrrhizinate as an anti-skin-aging component and yet has a suppressed sticky feeling.

[0011] Among them, the inventors have successfully created a topical skin preparation that contains dipotassium glycyrrhizinate but does not feel sticky after application and has excellent usability by combining 0.2 to 1.0% by mass of dipotassium glycyrrhizinate with respect to the entire topical skin preparation and one or more surfactants selected from polysorbate 60 and sucrose fatty acid ester. Furthermore, it has been found that such a topical skin preparation is excellent in usability also in terms of suppressing a squeaking feeling and a dry feeling, and is also excellent in suppressing crystal precipitation and has formulation stability. Based on such findings, the present invention has been completed.

[0012] <<Dipotassium glycyrrhizinate as component (A)>> In the topical skin preparation of the present invention, dipotassium glycyrrhizinate is included as component (A). The dipotassium glycyrrhizinate used in the present invention may be a synthetic product or may be obtained from natural products such as plants. Also, dipotassium glycyrrhizinate may be provided in the form of a plant extract containing them

[0013] Commercially available products may be used for dipotassium glycyrrhizinate, or, for example, those extracted from plants of the genus Glycyrrhiza of the legume family may be used. Examples of plants of the genus Glycyrrhiza of the legume family include Glycyrrhiza glabra, Glycyrrhiza uralensis, and Glycyrrhiza inflata.

[0014] The method for extracting dipotassium glycyrrhizinate from plants of the genus Glycyrrhiza of the legume family is not particularly limited, and a usual extraction method, that is, using a lower alcohol such as water or ethanol as a solvent, adding 1 to 20 times the amount to the plant body or its processed product, appropriately adding stirring as desired, immersing at room temperature for several days or at a temperature near the boiling point for several hours, removing insoluble matters by filtration or the like, and then, if desired, removing the solvent by distillation under reduced pressure or the like, and in some cases, purifying and fractionating by column chromatography or the like, can be used. Preferred plant parts for preparing the plant extract can be exemplified by, for example, rhizomes.​

[0015] In the skin external preparation of the present invention, the content of component (A) is 0.2 to 1.0% by mass based on the total amount of the skin external preparation. If it is within this range, excellent effects can be obtained in the present invention. Further, the content of component (A) may be 0.2% by mass or more, 0.3% by mass or more, or 0.5% by mass or more based on the total amount of the skin external preparation, and may be 1.0% by mass or less, 0.8% by mass or less, or 0.7% by mass or less, and these non - conflicting combinations may be used. Further, the content of component (A) may be 0.2 to 1.0% by mass, 0.3 to 0.8% by mass, or 0.5 to 0.7% by mass based on the total amount of the skin external preparation.

[0016] When the content of component (A) is 0.2% by mass or more, a sufficient skin anti - aging effect can be obtained. When it is 1.0% by mass or less, a smooth spreadability can be obtained, it is easy to form a uniform cosmetic film, and a sticky feeling is less likely to occur. Further, by using within such a range, a better usability such as no creaking feeling or dry feeling is easily obtained, and formulation stability is also easily obtained.

[0017] ≪At least one surfactant selected from polysorbate 60 and sucrose fatty acid ester of component (B)≫ In the skin external preparation of the present invention, as component (B), it contains at least one surfactant selected from polysorbate 60 and sucrose fatty acid ester. These surfactants are not particularly limited as long as they are usually contained in cosmetics, and commercially available products can be used.

[0018] As polysorbate 60 (polyoxyethylene (20) sorbitan monostearate), although not limited, for example, commercially available products such as Nikkol TS - 10V (manufactured by Nikko Chemicals Co., Ltd.) (HLB = 14.9) can be used. The fatty acid constituting the sucrose fatty acid ester may be either linear or branched, and may be either saturated or unsaturated. Although not limited, for example, esters of fatty acids having 12 to 18 carbon atoms, such as lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, and sucrose can be mentioned. More specifically, as the sucrose fatty acid ester, (mono) lauric acid sucrose, poly lauric acid sucrose (such as dilauric acid sucrose, trilauric acid sucrose, tetralauric acid sucrose, etc.), (mono) myristic acid sucrose, polymyristic acid sucrose (such as dimyristic acid sucrose, trimyristic acid sucrose, tetramyristic acid sucrose, etc.), (mono) palmitic acid sucrose, poly palmitic acid sucrose (such as dipalmitic acid sucrose, tripalmitic acid sucrose, tetrapalmitic acid sucrose, etc.), (mono) stearic acid sucrose, poly stearic acid sucrose (such as distearic acid sucrose, tristearic acid sucrose, tetrastearic acid sucrose, etc.), (mono) isostearic acid sucrose, poly isostearic acid sucrose (such as diisostearic acid sucrose, triisostearic acid sucrose, tetraisostearic acid sucrose, etc.) and the like can be mentioned. Such sucrose fatty acid esters can be contained alone or in combination of two or more kinds. Among them, one or more selected from sucrose laurate, sucrose myristate, sucrose palmitate, sucrose stearate, isostearic acid sucrose, and polysucrose stearate are preferably mentioned, and one or more selected from polysucrose stearate, sucrose stearate, and sucrose palmitate are more preferably mentioned. The HLB value of the sucrose fatty acid ester is not particularly limited, but those with an HLB value of 1 to 16 are preferred. In this specification, the HLB value refers to the value calculated from Griffin's formula. Examples of the sucrose fatty acid ester include, but are not limited to, Cosmerike S-10 (manufactured by Daiichi Kogyo Seiyaku Co., Ltd.) (HLB = 1) as polysucrose stearate, Cosmerike S-160 (manufactured by Daiichi Kogyo Seiyaku Co., Ltd.) (HLB = 15) as sucrose stearate, Surfhope SE COSME C-1616 (manufactured by Mitsubishi Chemical Foods Corporation) (HLB = 16) as sucrose palmitate, and other commercially available products can be used.

[0019] As component (B), one or more selected from polysorbate 60 and sucrose fatty acid ester can be combined and used in the present invention. That is, as component (B), only polysorbate 60 may be used, only sucrose fatty acid ester may be used, or a combination of two types of polysorbate 60 and sucrose fatty acid ester may be used.

[0020] In the external preparation for skin of the present invention, the content of component (B) is not limited, but for example, it may be 0.01% by mass or more, 0.1% by mass or more, 0.5% by mass or more, or 1% by mass or more based on the total amount of the external preparation for skin, and may be 10% by mass or less, 8% by mass or less, or 5% by mass or less, and these non-contradictory combinations may be used. Also, the content of component (B) may be 0.01 to 10% by mass, 0.1 to 8% by mass, 0.5 to 5% by mass, or 1 to 5% by mass based on the total amount of the external preparation for skin. By using within such a range, stickiness becomes less likely to be felt after applying the cosmetic. Also, by using within such a range, a more excellent usability such as no creaking feeling or dry feeling is likely to be obtained, and formulation stability is also likely to be obtained.

[0021] In addition, when using a combination of polysorbate 60 and sucrose fatty acid ester as component (B), the above content is the total amount of two or more kinds. These can be used in any mass ratio. The mass ratio in the case of combining polysorbate 60 and sucrose fatty acid ester is not particularly limited, but may be, for example, 10:1 to 1:10, or 1:1 to 1:5.

[0022] Moreover, the mass ratio of component (A) and component (B) in the present invention, as the mass ratio (B) / (A) of component (B) with respect to component (A), is not particularly limited from the viewpoints of usability, formulation stability, etc., but may be, for example, 0.1 to 50, 0.5 to 40, 1 to 25, or 1.2 to 5.

[0023] ≪Ultraviolet Absorbent of Component (C)≫ In the topical skin preparation of the present invention, a UV absorber can be included as component (C). The type of the UV absorber as component (C) is not particularly limited as long as it is a known one used in the field of topical skin preparations such as cosmetics. Examples thereof include cinnamic acid-based UV absorbers, benzophenone-based UV absorbers, benzoic acid-based UV absorbers, salicylic acid-based UV absorbers, dibenzoylmethane-based UV absorbers, anthranilic acid-based UV absorbers, urocanic acid-based UV absorbers, triazine-based UV absorbers and the like. Specifically, cinnamic acid-based UV absorbers such as 2-ethylhexyl p-methoxycinnamate, isopropyl p-methoxycinnamate, diethanolamine salt of p-methoxyhydrocinnamic acid, glyceryl p-methoxycinnamate mono-2-ethylhexanoate, octyl methoxycinnamate, methyl diisopropylcinnamate; 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfuric acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfate, 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2',4,Benzophenone-based UV absorbers such as 4'-tetrahydroxybenzophenone and 2-hydroxy-4-n-octoxybenzophenone; benzoic acid-based UV absorbers such as para-aminobenzoic acid, ethyl para-aminobenzoate, butyl para-aminobenzoate, 2-ethylhexyl para-dimethylaminobenzoate, glyceryl para-aminobenzoate, octyl para-dimethylaminobenzoate, amyl para-aminobenzoate, hexyl dimethylaminohydroxybenzoylbenzoate, and hexyl diethylaminohydroxybenzoylbenzoate; salicylic acid-based UV absorbers such as 2-ethylhexyl salicylate, triethanolamine salicylate, homomethyl salicylate, dipropylene glycol salicylate, methyl salicylate, ethylene glycol salicylate, phenyl salicylate, amyl salicylate, benzyl salicylate, isopropylbenzyl salicylate, and potassium salicylate; dibenzoylmethane-based UV absorbers such as 4-tert-butyl-4'-methoxydibenzoylmethane, 4-isopropyldibenzoylmethane, 4-methoxydibenzoylmethane, and 4-tert-butyl-4'-hydroxydibenzoylmethane; anthranilic acid-based UV absorbers such as menthyl anthranilate; urocanic acid-based UV absorbers such as ethyl urocanate; triazine-based UV absorbers such as bis(ethylhexyl)oxyphenol methoxyphenyltriazine and ethylhexyl triazone, etc.

[0024] As the ultraviolet absorber of component (C), it is preferable to contain one or more selected from cinnamic acid-based ultraviolet absorbers and benzoic acid-based ultraviolet absorbers. Among them, para-methoxycinnamic acid 2-ethylhexyl (pharmaceutical external preparation display name) (cosmetic display name: ethylhexyl methoxycinnamate; external preparation display abbreviation: ethylhexyl para-methoxycinnamate), dimethylaminohydroxybenzoyl benzoic acid hexyl (cosmetic display name) (pharmaceutical external preparation display name: 2-[4-(dimethylamino)-2-hydroxybenzoyl]benzoic acid hexyl ester), and it is preferable to contain one or two selected from them. As the ultraviolet absorber, commercially available products can be used. The ultraviolet absorber may be blended alone or in combination of two or more.

[0025] In the external preparation for skin of the present invention, the content of component (C) is not limited. For example, it may be 0.01% by mass or more, 0.1% by mass or more, or 1% by mass or more with respect to the whole external preparation for skin, and may be 15% by mass or less, 10% by mass or less, or 5% by mass or less, and these non-contradictory combinations may be used. Also, the content of component (C) may be 0.01 to 15% by mass, 0.1 to 10% by mass, or 1 to 5% by mass with respect to the whole external preparation for skin.

[0026] By using within such a range, an excellent ultraviolet absorption effect can be obtained without impairing the effects of the present invention. When two or more components (C) are used in combination, the above content is the total amount of two or more. The mass ratio when combining two or more components (C) is not particularly limited.

[0027] ≪Ultraviolet Scattering Agent of Component (D)≫ In the topical skin preparation of the present invention, an ultraviolet scattering agent can be included as component (D). The type of the ultraviolet scattering agent is not particularly limited as long as it is a known one used in the field of topical skin preparations such as cosmetics. For example, it is a fine particle metal oxide having a function of scattering ultraviolet rays, and the type is not particularly limited as long as it can be blended into an emulsified composition or the like. Examples of the metal oxide include titanium oxide, titanium dioxide, zinc oxide, zirconium oxide, cerium oxide and the like. In addition, only one kind of the ultraviolet scattering agent may be blended, or two or more kinds may be blended in combination.

[0028] The fine particle metal oxide has a particle diameter referred to as fine particles in the technical field. For example, the primary particle diameter observed by an electron microscope is usually 5 nm to 100 nm, preferably 10 nm to 80 nm.

[0029] Since the ultraviolet scattering agent used in the present invention is excellent in the ultraviolet scattering effect, it preferably contains one or two kinds selected from fine particle titanium oxide and fine particle zinc oxide.

[0030] The ultraviolet scattering agent used in the present invention can be prepared by a conventional method such as thermal decomposition of a corresponding metal salt in the gas phase, but a commercially available product can also be used.

[0031] In the present invention, it is preferable that the surface of the ultraviolet scattering agent is coated with an inorganic compound such as silica or alumina, or an organic compound such as a surfactant such as stearic acid, isostearic acid or sodium alginate, or a silicone compound such as silicone oil. When the coating treatment is performed, it can be performed by a known surface treatment method.

[0032] The ultraviolet scattering agent preferably has oil phase dispersibility. Since the ultraviolet scattering agent having oil phase dispersibility is uniformly dispersed in the oil phase, the topical skin preparation of the present invention in such a form is excellent in water resistance and ultraviolet protection function.

[0033] As the oil-dispersible ultraviolet scattering agent, those subjected to a hydrophobization treatment, for example, an ultraviolet scattering agent whose surface is coated with a hydrophobic compound, can be preferably exemplified. As such an oil-dispersible ultraviolet scattering agent, although not limited, an ultraviolet scattering agent coated with a hydrophobic organic compound is preferably used.

[0034] In the external preparation for skin of the present invention, the content of component (D) is not limited, but for example, it may be 0.01% by mass or more, 0.1% by mass or more, or 1% by mass or more with respect to the entire external preparation for skin, and may be 15% by mass or less, 10% by mass or less, or 6% by mass or less, and may be any non-contradictory combination thereof. Further, the content of component (D) may be 0.01 to 15% by mass, 0.1 to 10% by mass, or 1 to 6% by mass with respect to the entire external preparation for skin. By using in such a range, an excellent ultraviolet scattering effect can be obtained without impairing the effects of the present invention. When two or more kinds of component (D) are used in combination, the above content is the total amount of two or more kinds. The mass ratio in the case of combining two or more kinds of component (D) is not particularly limited.

[0035] ≪External preparation for skin≫ The dosage form of the external preparation for skin of the present invention is not particularly limited, such as an aqueous dosage form or an emulsified dosage form, etc., but an emulsified dosage form is preferred. It may be an oil-in-water type or a water-in-oil type, but an oil-in-water type emulsified dosage form is particularly preferred. As the oil-in-water type emulsified dosage form, it is not particularly limited as long as the outermost phase is an oil phase, and in addition to the W / O type, it may be an O / W / O type or a (W1 + W2) / O type, etc.

[0036] When the external preparation for skin of the present invention is in an emulsified dosage form, it contains an aqueous phase component and an oil phase component. As the aqueous phase component, the external preparation for skin of the present invention contains water. Further, in addition to water, the aqueous phase component may be any component that dissolves in water at 2 It may be any component that dissolves in water at 5 to 90°C. The oil phase component is not limited to oils, and generally includes powders, etc., and may be any component that suspends in water at 25 to 90°C and phase-separates from water after standing for 1 hour. When the external preparation for skin of the present invention is of an emulsifier type, the mass ratio of the content of the aqueous phase component to the oil phase component is not particularly limited, but is preferably 30:70 to 90:10, more preferably 60:40 to 85:15.

[0037] The external preparation for skin of the present invention can be used, for example, in the forms of pharmaceuticals, cosmetics including quasi-drugs, etc. Particularly preferred is cosmetics. Specific forms of cosmetics include, for example, skin care cosmetics such as lotions, milky lotions, creams, makeup bases, makeup cosmetics such as foundations, sunscreen milky lotions, sunscreen creams and other sunscreen cosmetics. Also, as the properties of the cosmetics, various properties such as liquid, milky lotion, cream, etc. can be selected.

[0038] ≪Optional Components≫ In addition, the external preparation for skin of the present invention can contain optional components other than the above components as long as its effects are not impaired. The optional components are not particularly limited as long as they are known ones used in the field of external preparations for skin such as cosmetics and can be used. As the optional components, one kind or a combination of two or more kinds can be used in the present invention.

[0039] Examples of such optional components include oil agents, powders, alcohols, ethers, moisturizing agents, surfactants, sequestering agents, pearl agents, amino acids, organic amines, polymer emulsions, pH adjusters, vitamins, antioxidants, preservatives, water-soluble polymers, fragrances, various active ingredients, etc.

[0040] Examples of the oil agents include silicone oils, polar oils, natural oils, hydrocarbons, etc.

[0041] Examples of the silicone oils include dimethylpolysiloxane (dimethicone), cyclopentasiloxane, decamethylcyclopentasiloxane, caprylyl methicone, trimethylsiloxysilicic acid, etc.

[0042] Examples of polar oils include synthetic ester oils such as isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate, cholesteryl 12-hydroxystearate, ethylene glycol di-2-ethylhexanoate, dipentaerythritol fatty acid ester, N-alkyl glycol monoisostearate, neopentyl glycol dicaprate, diisostearyl malate, glyceryl di-2-heptylundecanoate, trimethylolpropane tri-2-ethylhexanoate, trimethylolpropane triisostearate, pentaerythritol tetra-2-ethylhexanoate, glyceryl tri-2-ethylhexanoate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, glyceryl trimyristate, glyceryl tri-2-heptylundecanoate, methyl ester of castor oil fatty acid, oleic acid oil, cetostearyl alcohol, acetoglyceride, 2-heptylundecyl palmitate, diisobutyl adipate, 2-octyldodecyl N-lauroyl-L-glutamate, di-2-heptylundecyl adipate, ethyl laurate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate, isononyl isononanoate, ethyl acetate, butyl acetate, amyl acetate, triethyl citrate, etc.

[0043] Examples of natural oils include avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, peppermint oil, wheat germ oil, sasanqua oil, castor oil, linseed oil, safflower oil, cottonseed oil, rice bran oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran wax oil, sinagiri oil, Japanese cedar oil, jojoba oil, germ oil, sunflower oil, triglyceride, glyceryl trioctanoate, glyceryl triisopalmitate, and the like.

[0044] Examples of hydrocarbon oils include isododecane, isohexadecane, squalane, hydrogenated poly(C6-12) olefin, hydrogenated polyisobutene, and the like.

[0045] The powder is not particularly limited in its shape, such as spherical, needle-like, plate-like, etc. For example, inorganic white pigments (e.g., titanium dioxide, zinc oxide, etc.); inorganic red pigments (e.g., iron oxide (red lead), iron titanate, etc.); inorganic brown pigments (e.g., γ-iron oxide, etc.); inorganic yellow pigments (e.g., yellow iron oxide, loess, etc.); inorganic black pigments (e.g., black iron oxide, lower-order titanium oxide, etc.); inorganic purple pigments (e.g., manganese violet, cobalt violet, etc.); inorganic green pigments (e.g., chromium oxide, chromium hydroxide, cobalt titanate, etc.); inorganic blue pigments (e.g., ultramarine, dark blue, etc.); pearl pigments (e.g., titanium dioxide-coated mica, titanium dioxide-coated bismuth oxychloride, titanium dioxide-coated talc, colored titanium dioxide-coated mica, bismuth oxychloride, fish scale foil, etc.); metal powder pigments (e.g., aluminum powder, copper powder, etc.); organic pigments such as zirconium, barium or aluminum lakes (e.g., organic pigments such as Red No. 201, Red No. 202, Red No. 204, Red No. 205, Red No. 220, Red No. 226, Red No. 228, Red No. 405, Orange No. 203, Orange No. 204, Yellow No. 205, Yellow No. 401, and Blue No. 404, etc., Red No. 3, Red No. 104, Red No. 106, Red No. 227, Red No. 230, Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203, Green No. 3 and Blue No. 1, etc.); natural pigments (e.g., chlorophyll, β-carotene, etc.); inorganic powders (e.g., talc, kaolin, mica, sericite, muscovite, phlogopite, synthetic mica, biotite, vermiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, silica, alumina, zeolite, barium sulfate, calcined calcium sulfate (calcined gypsum), calcium phosphate, fluorapatite, hydroxyapatite, ceramic powder, boron nitride, etc.);Organic powders (e.g., polyamide resin powders (nylon powders), polyethylene powders, poly(methyl methacrylate) powders, polystyrene powders, copolymer resin powders of styrene and acrylic acid, silicone resin powders, benzoguanamine resin powders, polytetrafluoroethylene powders, cellulose powders, silicone composite spherical powders (e.g., (vinyldimethylsilicone / methylsilsesquioxane) copolymer, (diphenyldimethylsilicone / vinyldiphenyldimethylsilicone / silsesquioxane) copolymer, polysilicone-22, polysilicone-1 copolymer, etc.), etc.); metal soaps (e.g., zinc myristate, calcium palmitate, aluminum stearate); organically modified clay minerals (e.g., organically modified bentonite, organically modified hectorite, etc.), etc. can be mentioned.;

[0046] Examples of the alcohol include monohydric alcohols such as ethanol, isopropanol, cetanol, batyl alcohol, behenyl alcohol, palmitoleyl alcohol, heptadecanol, 1-heptadecanol, stearyl alcohol, isostearyl alcohol, elaidyl alcohol, oleyl alcohol, linoleyl alcohol, elaidolinoleyl alcohol, linolenyl alcohol, elaidolinolenyl alcohol, ricinoleyl alcohol, nonadecyl alcohol, arachidyl alcohol, heneicosanol, erucyl alcohol, etc.; dihydric alcohols such as ethylene glycol, 1,3-butylene glycol, trimethylene glycol, 1,2-butylene glycol, propylene glycol, dipropylene glycol, propanediol, 1,2-pentanediol, 3-methyl-1,3-butanediol, tetramethylene glycol, 2,3-butylene glycol, pentamethylene glycol, 2-butene-1,4-diol, hexylene glycol, octylene glycol, etc.; trihydric alcohols such as trimethylolpropane; tetrahydric alcohols such as pentaerythritol; pentahydric alcohols such as xylitol; polyhydric alcohol polymers such as triglycerin, tetraglycerin, polyglycerin; sugar alcohols such as starch-decomposed sugar-reduced alcohol; polyglycerin; Alcohol alkyl ethers such as ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol monophenyl ether, ethylene glycol monohexyl ether, ethylene glycol mono-2-methylhexyl ether, ethylene glycol isoamyl ether, ethylene glycol benzyl ether, ethylene glycol isopropyl ether, etc.; Alcohol alkyl ethers such as diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, triethylene glycol monomethyl ether, triethylene glycol monoethyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol monobutyl ether, propylene glycol isopropyl ether, dipropylene glycol methyl ether, dipropylene glycol ethyl ether, dipropylene glycol butyl ether, etc.; Glycerin monoalkyl ethers such as xylyl alcohol, cerakyl alcohol, batyl alcohol, etc.; Alcohol polymers such as diethylene glycol, triethylene glycol, polypropylene glycol, tetraethylene glycol, polyethylene glycol, etc.; Examples include glycolid; tetrahydrofurfuryl alcohol; POE-tetrahydrofurfuryl alcohol; POP-butyl ether; POP·POE-butyl ether; tripolyoxypropylene glycerin ether; POP-glycerin ether; POP-glycerin ether phosphate; POP·POE-pentaerythritol ether, etc.

[0047] Examples of ethers include, in addition to those corresponding to the above alcohols, ethylene glycol dimethyl ether, ethylene glycol diethyl ether, ethylene glycol dibutyl ether, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, diethylene glycol methyl ethyl ether, ethylene glycol monomethyl ether acetate, ethylene glycol monoethyl ether acetate, ethylene glycol monobutyl ether acetate, ethylene glycol monophenyl ether acetate, ethylene glycol diadipate, ethylene glycol disuccinate, diethylene glycol monoethyl ether acetate, diethylene glycol monobutyl ether acetate, propylene glycol monomethyl ether acetate, propylene glycol monoethyl ether acetate, propylene glycol monopropyl ether acetate, propylene glycol monophenyl ether acetate, and the like.

[0048] Examples of humectants include, for example, chondroitin sulfate and its salts, hyaluronic acid and its salts, mucitin sulfate, calonic acid, atelocollagen, cholesteryl-12-hydroxystearate, sodium lactate, dl-pyrrolidone carboxylate, short-chain soluble collagen, diglycerin (EO) PO adduct, Rosa multiflora extract, Primula sieboldii extract, Melilotus officinalis extract, and the like.

[0049] Examples of surfactants include anionic surfactants, cationic surfactants, amphoteric surfactants , and nonionic surfactants.

[0050] Examples of anionic surfactants include, for example, fatty acid soaps (e.g., sodium laurate, sodium palmitate, etc.); higher alkyl sulfate esters (e.g., sodium lauryl sulfate, potassium lauryl sulfate, etc.); alkyl ether sulfate esters (e.g., triethanolamine POE lauryl sulfate, sodium POE lauryl sulfate, etc.); N-acyl sarcosine acids (e.g., sodium lauroyl sarcosine, etc.); higher fatty acid amide sulfonates (e.g., sodium N-myristoyl-N-methyltaurine, sodium coconut fatty acid methyl tauride, sodium lauryl methyl tauride, etc.); phosphate esters (sodium POE oleyl ether phosphate, POE stearyl ether phosphate, etc.); sulfosuccinates (e.g., sodium di-2-ethylhexyl sulfosuccinate, sodium monolauroyl monoethanolamine polyoxyethylene sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate, etc.); alkylbenzene sulfonates (e.g., sodium linear dodecylbenzene sulfonate, triethanolamine linear dodecylbenzene sulfonate, linear dodecylbenzene sulfonic acid, etc.); higher fatty acid ester sulfate esters (e.g., sodium hardened coconut oil fatty acid glycerol sulfate, etc.); N-acyl glutamates (e.g., monosodium N-lauroyl glutamate, disodium N-stearoyl glutamate, monosodium N-myristoyl-L-glutamate, etc.); sulfated oils (e.g., castor oil, etc.); POE alkyl ether carboxylic acids; POE alkyl allyl ether carboxylates; α-olefin sulfonates; higher fatty acid ester sulfonates; secondary alcohol sulfate esters; higher fatty acid alkyloleamide sulfate esters; sodium lauroyl monoethanolamine succinate; N-palmitoyl aspartic acid ditriethanolamine; sodium caseinate, etc.

[0051] Examples of cationic surfactants include alkyltrimethylammonium salts (e.g., stearyltrimethylammonium chloride, lauryltrimethylammonium chloride, etc.); alkylpyridinium salts (e.g., cetylpyridinium chloride, etc.); distearyldimethylammonium chloride dialkyldimethylammonium salts; poly(N,N'-dimethyl-3,5-methylenepiperidinium) chloride; alkyl quaternary ammonium salts; alkyldimethylbenzylammonium salts; alkylisoquinolinium salts; dialkylmorphonium salts; POE alkylamines; alkylamine salts; polyamine fatty acid derivatives; amyl alcohol fatty acid derivatives; benzalkonium chloride; benzethonium chloride, etc.

[0052] Examples of amphoteric surfactants include imidazoline-based amphoteric surfactants (e.g., 2-undecyl-N,N,N-(hydroxyethylcarboxymethyl)-2-imidazoline sodium, 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy 2 sodium salt, etc.); betaine-based surfactants (e.g., 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryldimethylaminoacetic acid betaine, alkyl betaine, amide betaine, sulfobetaine, etc.).

[0053] Examples of nonionic surfactants include polyether-modified silicones (e.g., polyethylene glycol-10 dimethicone, polyethylene glycol-12 dimethicone, PEG-9 polymethylsiloxyethyl dimethicone, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, PEG-9 polydimethylsiloxyethyl dimethicone, etc.); polyglycerin-modified silicones (e.g., polyglyceryl-3 disiloxane dimethicone, polyglyceryl-3 polydimethylsiloxyethyl dimethicone, etc.); sorbitan fatty acid esters (e.g., sorbitan monooleate, sorbitan monostearate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexanoate, diglycerol sorbitan tetra-2-ethylhexanoate, etc.); glycerin fatty acids (e.g., glycerin monoricinoleate, glycerin monoelaidate, glycerin sesquioleate, glycerin monostearate, α,α'-oleic acid pyroglutamic acid glycerin, glycerin monostearate malate, etc.); propylene glycol fatty acid esters (e.g., propylene glycol monostearate, etc.); POE castor oil / hydrogenated castor oil derivatives (POE castor oil, POE hydrogenated castor oil, etc.); non-hydrophilic nonionic surfactants such as glycerin alkyl ethers. Also, polyglycerin fatty acid esters (e.g., polyglyceryl monooleate, polyglyceryl monostearate, etc.); POE sorbitan fatty acid esters (e.g., POE sorbitan monooleate, POE sorbitan monostearate, POE sorbitan tetraoleate, etc.); POE sorbit fatty acid esters (e.g., POE sorbit monolaurate, POE sorbit monooleate, POE sorbit pentaoleate, POE sorbit monostearate, etc.); POE glycerin fatty acid esters (e.g., POE glycerin monostearate, POE glycerin monoisostearate, POE glycerin triisostearate, etc., such as POE monooleate, etc.);POE fatty acid esters (e.g., POE distearate, POE monodioleate, ethylene glycol distearate, etc.); POE alkyl ethers (e.g., POE lauryl ether, POE oleyl ether, POE stearyl ether, POE-behenyl ether, POE-2-octyldodecyl ether, POE cholestanol ether, etc.); POE alkyl phenyl ethers (e.g., POE nonylphenyl ether, etc.); Pluronic types (e.g., Pluronic (registered trademark), etc.); POE·POP alkyl ethers (e.g., POE·POP cetyl ether, POE·POP-2-decyltetradecyl ether, POE·POP monobutyl ether, POE·POP hydrogenated lanolin, POE·POP glycerin ether, etc.); Tetra POE·tetra POP ethylene diamine condensates (e.g., Tetronic, etc.); POE castor oil hydrogenated castor oil derivatives (e.g., POE castor oil, POE hydrogenated castor oil, POE hydrogenated castor oil monoisostearate, POE hydrogenated castor oil triisostearate, POE hydrogenated castor oil monopyroglutamic acid monoisostearic acid diester, POE hydrogenated castor oil maleic acid, etc.); POE beeswax·lanolin derivatives (e.g., POE sorbitol beeswax, etc.); Alkanolamides (e.g., coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide, etc.); POE propylene glycol fatty acid ester; POE alkylamine; POE fatty acid amide; Alkyl glucoside; Alkyl ethoxydimethylamine oxide; Hydrophilic nonionic surfactants such as trioleyl phosphate are also included.;

[0054] Examples of the sequestering agent for metal ions include 1-hydroxyethane-1,1-diphosphonic acid, tetrasodium salt of 1-hydroxyethane-1,1-diphosphonic acid, disodium edetate, trisodium edetate, tetrasodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, edetic acid, trisodium ethylenediamine hydroxyethyltriacetate, etc.

[0055] Examples of the pearl agent include glycol distearate, titanium mica, etc.

[0056] Examples of the amino acids include neutral amino acids (e.g., threonine, cysteine, etc.); basic amino acids (e.g., hydroxylysine, etc.). Further, examples of the amino acid derivatives include sodium acyl sarcosinate (sodium lauroyl sarcosinate), acyl glutamate, sodium acyl-β-alanine, glutathione, pyrrolidone carboxylic acid, etc.

[0057] Examples of the organic amines include monoethanolamine, diethanolamine, trieth anolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-methyl-1-propanol, etc.

[0058] Examples of the polymer emulsion include acrylic resin emulsion, polyethyl acrylate emulsion, acrylic resin solution, polyalkyl acrylate emulsion, polyvinyl acetate resin emulsion, natural rubber latex, etc.

[0059] Examples of the pH adjuster include buffers such as lactic acid-sodium lactate, citric acid-sodium citrate, succinic acid-sodium succinate, etc., and they are usually used for adjusting the pH of the internal phase (aqueous component).

[0060] Examples of the vitamins include vitamin A, B1, B2, B6, C, E and their derivatives, pantothenic acid and its derivatives, biotin, etc.

[0061] Examples of antioxidants include tocopherols, dibutylhydroxytoluene (BHT), butylhydroxyanisole, pyrosulfite, gallate, phosphoric acid, citric acid, ascorbic acid, maleic acid, malonic acid, succinic acid, fumaric acid, cephalin, hexametaphosphate, phytic acid, ethylenediaminetetraacetate, and the like.

[0062] Examples of preservatives include parabens, phenoxyethanol, and the like.

[0063] Examples of water-soluble polymers include natural water-soluble polymers such as plant-based polymers (e.g., gum arabic, tragacanth gum, galactan, guar gum, carob gum, karaya gum, carrageenan, pectin, agar, quince seed (marmelo), algal colloid (cassou extract), starch (rice, corn, potato, wheat)); microbial-based polymers (e.g., xanthan gum, dextran, succinoglucan, pullulan, etc.); animal-based polymers (e.g., collagen, casein, albumin, gelatin, etc.). Semi-synthetic water-soluble polymers such as starch-based polymers (e.g., carboxymethyl starch, methylhydroxypropyl starch, etc.); cellulose-based polymers (hydroxypropylmethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, methyl cellulose, ethyl cellulose, hydroxypropylmethyl cellulose stearoxy ether, sodium cellulose sulfate, carboxymethyl cellulose, sodium carboxymethyl cellulose, crystalline cellulose, cellulose powder, etc.); alginic acid-based polymers (e.g., sodium alginate, propylene glycol alginate, etc.). Synthetic water-soluble polymers such as polyoxyethylene-based polymers (e.g., polyethylene glycol 20,000, 40,000, 60,000, etc.); polyethyleneimine; cationic polymers.

[0064] Examples of various active ingredients include anti-inflammatory agents (e.g., salicylic acid derivatives, hinokitiol, zinc oxide, allantoin, etc.); whitening agents (e.g., placenta extract, snowdrop extract, arbutin, resorcinol derivatives, etc.); various extracts (e.g., peony, turmeric, bitter orange, peony root, ginseng, birch, sage, loquat, carrot, aloe, butterbur, iris, grape, glycyrrhiza, loofah, lily, saffron, cnidium, ginger, viola, ononis, garlic, capsicum, chinpi, toki, seaweed, etc.), activators (e.g., royal jelly, photosensitizer, cholesterol derivatives, etc.); blood circulation promoters (e.g., nonivamide, benzyl nicotinate, β-butoxyethyl nicotinate, capsaicin, zingerone, cantharidin, ichthyol, tannic acid, α-borneol, tocopherol nicotinate, inositol hexanicotinate, cyclandelate, cinnarizine, tolazoline, acetylcholine, verapamil, cephalanthin, γ-oryzanol, etc.); anti-seborrheic agents (e.g., sulfur, thiantol, etc.); anti-inflammatory agents (e.g., tranexamic acid, thiotaurine, hypotaurine, etc.), and the like.

[0065] These optional components can be added at any step in the present invention or before and after it.

[0066] <Manufacturing Method> One aspect of the present invention relates to a method for manufacturing an external preparation for skin (hereinafter sometimes referred to as "the manufacturing method of the present invention"), which includes a step of blending the following components (A) and (B). (A) Dipotassium glycyrrhizinate in an amount of 0.2 to 1.0% by mass based on the total amount of the external preparation for skin, (B) One or more selected from polysorbate 60 and sucrose fatty acid ester. Note that the matters described in the section of <External Preparation for Skin> are all applicable to the description of the manufacturing method of the present invention.

[0067] The manufacturing method of the present invention is characterized by manufacturing a topical skin preparation with suppressed stickiness by blending specific components (A) and (B). The specific ranges of the blending amounts and blending amount ratios of components (A) and (B) are the same as those described in the section of <topical skin preparation>.

[0068] The manufacturing method of the topical skin preparation of the present invention can be carried out based on conventional methods except for having the above essential constituent components. For example, when component (B) is lipophilic, the oil phase component containing component (B) is heated and dissolved, and the powder component is added and dispersed. Then, when component (A) and component (B) are hydrophilic, the aqueous phase component containing component (B) is added to the heated and dissolved oil phase component, and emulsified while stirring to obtain an oil-in-water type emulsifier type topical skin preparation.

Example

[0069] Hereinafter, the present invention will be specifically described by way of examples, but these are examples of the present invention and the scope of the present invention is not limited thereto.

[0070] With the formulation shown in Table 1, the oil phase component was heated to 70°C and dissolved, and the powder component was added and dispersed. The aqueous phase component, which was also heated and dissolved at 70°C, was added to the oil phase and emulsified while stirring with a homomixer to prepare an oil-in-water emulsified cosmetic. As for polysorbate 60, Nikkol TS-10V (manufactured by Nikko Chemicals Co., Ltd.) was used, and as for sucrose polystearate, Cosmerike S-10 (manufactured by Daiichi Kogyo Seiyaku Co., Ltd.) was used. For each of the obtained cosmetics, the following items were evaluated. The results are also shown in Table 1.

[0071] (Absence of stickiness) An appropriate amount of the cosmetic was applied to the skin, and a professional evaluator scored the stickiness of the skin 1 minute after application according to the following criteria. 5 points: No stickiness is felt. 4 points: Almost no stickiness is felt. 3 points: Slightly sticky is felt. 2 points: Stickiness is felt. 1 point: Feels very sticky The average scores of 10 evaluators were applied to the following evaluations. ◎: Exceeds 4 points: Very good ○: Exceeds 3 points and is 4 points or less: Good △: Exceeds 2 points and is 3 points or less: Slightly poor ×: 2 points or less: Poor

[0072] (Absence of creaking sensation) An appropriate amount of the cosmetic was applied to the skin, and a professional evaluator scored the creaking sensation of the skin during application according to the following criteria. 5 points: No creaking sensation is felt 4 points: Almost no creaking sensation is felt 3 points: Slightly creaking sensation is felt 2 points: Creaking sensation is felt 1 point: Very strong creaking sensation is felt The average scores of 10 evaluators were applied to the following evaluations. ◎: Exceeds 4 points: Very good ○: Exceeds 3 points and is 4 points or less: Good △: Exceeds 2 points and is 3 points or less: Slightly poor ×: 2 points or less: Poor

[0073] (Moist feeling) An appropriate amount of the cosmetic was applied to the skin, and a professional evaluator scored the moist feeling of the skin 1 minute after application according to the following criteria. 5 points: Feels very moist 4 points: Feels moist 3 points: Feels slightly moist 2 points: Almost no moist feeling is felt 1 point: No moist feeling is felt The average scores of 10 evaluators were applied to the following evaluations. ◎: Exceeds 4 points: Very good ○: Exceeds 3 points and is 4 points or less: Good △: Exceeds 2 points and is 3 points or less: Slightly poor ×: 2 points or less: Poor

[0074] (Stability of the preparation) Each cosmetic was placed in a glass standard bottle and left standing in a thermostat set at 0°C for one month, and then a professional evaluator visually evaluated it in the following four grades. ◎: No precipitation of crystals was observed. 〇: A very small amount of crystal precipitation was observed. △: A small amount of crystal precipitation was observed. ×: Crystal precipitation was observed.

[0075]

Table 1

[0076] It was found that the cosmetics of the examples containing component (A) and component (B) were excellent in non-stickiness. Furthermore, they were also excellent in usability such as no scratchy feeling and moist feeling (no dry feeling), and in the stability of the formulation such as suppression of crystal precipitation. On the other hand, Comparative Example 1 that did not contain component (B) and Comparative Example 2 in which component (A) exceeded the specified range had insufficient usability. Also, the stability of the formulation was insufficient.

Industrial Applicability

[0077] The present invention can be applied to cosmetics including external skin preparations, pharmaceuticals, quasi-drugs, etc.

Claims

1. The following components (A) and (B): (A) Dipotassium glycyrrhizinate in an amount of 0.2 to 1.0% by mass based on the total amount of the external preparation for skin; (B) One or more selected from polysorbate 60 and sucrose fatty acid ester, The external preparation for skin containing the same.

2. The external preparation for skin according to claim 1, wherein the sucrose fatty acid ester of component (B) contains one or more selected from sucrose laurate, sucrose myristate, sucrose palmitate, sucrose stearate, sucrose isostearate, and sucrose polystearate.

3. The external preparation for skin according to claim 1, wherein the sucrose fatty acid ester of component (B) contains one or more selected from sucrose polystearate, sucrose stearate, and sucrose palmitate.

4. The sunscreen external preparation for skin according to claim 1, containing 0.01 to 10% by mass of component (B) based on the total amount of the external preparation for skin.

5. The external preparation for skin according to claim 1, wherein the mass ratio of the contents of components (A) and (B) ((B) / (A)) is 0.1 to 50.

6. The external preparation for skin according to claim 1, further containing component (C) an ultraviolet absorber.

7. The external preparation for skin according to claim 6, wherein the ultraviolet absorber of component (C) contains ethylhexyl methoxycinnamate and / or hexyl dimethylaminohydroxybenzoyl benzoate.

8. The external preparation for skin according to claim 6, containing 0.01 to 15% by mass of component (C) based on the total amount of the external preparation for skin.

9. The external preparation for skin according to claim 1, further containing (D) an ultraviolet scattering agent.

10. The external preparation for skin according to claim 9, wherein the ultraviolet scattering agent of component (D) contains fine particle titanium oxide and / or fine particle zinc oxide.

11. The external preparation for skin according to claim 9, wherein component (D) is hydrophobically treated.

12. The external preparation for skin according to claim 9, containing 0.01 to 15% by mass of component (D) based on the total amount of the external preparation for skin.

13. The external preparation for skin according to claim 1, which is for sunscreen.

14. The following components (A) and (B): (A) Dipotassium glycyrrhizinate in an amount of 0.2 to 1.0% by mass based on the total amount of the external preparation for skin; (B) One or more selected from polysorbate 60 and sucrose fatty acid ester, A method for producing an external preparation for skin, including the step of blending the same.

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