Indwelling member

Abstract

To provide an indwelling member that can be prevented from causing disturbance of an inspection using X-ray in the case of indwelling in a living body.SOLUTION: An indwelling member includes a tube and a fluid body. The tube has a tubular shape. The fluid body has flowability and X-ray transmissivity different from that of the tube and is put in the tube.SELECTED DRAWING: Figure 3

Description

[Technical Field]

[0001] The present disclosure relates to an in-vivo implantable device. [Background technology]

[0002] For example, embolization is known as a treatment for aneurysms, hemorrhagic lesions, etc., in which an embolization coil is used to embolize a target site in a living body. Embolization is generally performed under X-ray fluoroscopy. For this reason, embolization coils are generally made of a metal such as platinum that has low X-ray transparency (see Patent Document 1). [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Special Publication No. 2017-528247 Summary of the Invention [Problem to be solved by the invention]

[0004] However, when an embolic coil is placed inside a living body, it can interfere with X-ray examinations, such as those for follow-up observation after embolization or for examining other lesions, because the embolic coil tends to block the transmission of X-rays.

[0005] Such problems may arise not only in embolic coils but also in other in-vivo indwelling devices that are placed in the living body.

[0006] It is preferable that one aspect of the present disclosure provides an in-vivo indwelling device that can suppress interference with examinations using X-rays when placed in a living body. [Means for solving the problem]

[0007] One aspect of the present disclosure is an in-vivo implantation device comprising a tube and a fluid. The tube is tubular. The fluid has flowability and X-ray transparency different from that of the tube, and is placed in the tube. With this configuration, when the in-vivo implantation device is implanted in a living body, it is possible to prevent the in-vivo implantation device from interfering with examinations using X-rays.

[0008] In one embodiment of the present disclosure, the fluid may have lower X-ray transparency than the tube, which further prevents the implanted device from interfering with X-ray examinations when implanted in a living body.

[0009] In one aspect of the present disclosure, the sidewall of the tube may be formed with a plurality of holes, which has the effect of preventing the implanted device from interfering with X-ray examinations in a shorter period of time after the implanted device is placed in a living body.

[0010] In one embodiment of the present disclosure, the distal end of the tube may be closed, which allows a physician to easily visualize the distal end of the tube under X-ray fluoroscopy during the process of placing the implanted device in a living body.

[0011] In one aspect of the present disclosure, the fluid may be a liquid contrast agent.

[0012] According to an aspect of the present disclosure, the tube may further include a porous body having a plurality of holes formed therein and disposed inside the tube. The fluid may be impregnated into the porous body. This configuration can reduce the outflow rate of the fluid from the tube.

[0013] In one aspect of the present disclosure, the tube may be made of a polymer. With this configuration, when the in-vivo indwelling device is placed in a living body, the in-vivo indwelling device can be further prevented from interfering with examinations using X-rays. [Brief explanation of the drawings]

[0014] [Figure 1] FIG. 1 is a plan view of the implanted device. [Figure 2] Fig. 2A is a cross-sectional view of the distal end of the implanted device, Fig. 2B is a cross-sectional view of the portion of the implanted device where a marker is provided, and Fig. 2C is a cross-sectional view of the proximal end of the implanted device. [Figure 3] Figure 3A is a schematic diagram showing the state in which the implanted device has reached the cerebral aneurysm, Figure 3B is a schematic diagram showing the state in which the implanted device has been inserted into the cerebral aneurysm, and Figure 3C is a schematic diagram showing the state in which the implanted device has embolized the cerebral aneurysm. [Figure 4] FIG. 4 is a schematic diagram showing the state in which the implanted device is inserted into the abdominal aortic aneurysm. [Figure 5] FIG. 5 is a schematic diagram showing the state in which the implanted device is inserted into the inside of a dissecting aortic aneurysm. [Figure 6] FIG. 6 is a cross-sectional view of the distal end portion of an implanted device that does not include a porous body. [Figure 7] FIG. 7 is a cross-sectional view of the distal end portion of the implanted device, showing a modified example of the tube. DETAILED DESCRIPTION OF THE INVENTION

[0015] Hereinafter, exemplary embodiments of the present disclosure will be described with reference to the drawings.

[0016] [1. Configuration] The implantable device 1 shown in FIG. 1 is a device configured to be implanted in a living body. The implantable device 1 is biocompatible. The implantable device 1 is used, for example, in occlusion surgery to occlude aneurysms. Specific examples of aneurysms include a cerebral aneurysm A1 shown in FIG. 3A, an abdominal aortic aneurysm A2 shown in FIG. 4, a thoracic aortic aneurysm (not shown), and a dissecting aortic aneurysm (also known as aortic dissection) A3 shown in FIG. 5. A cerebral aneurysm A1 generally has a diameter of 5 to 8 mm. An abdominal aortic aneurysm A2, a thoracic aortic aneurysm, and a dissecting aortic aneurysm A3 generally have a diameter of 50 to 80 mm. The implantable device 1 is preferably used for relatively large aneurysms (i.e., aortic aneurysms) such as an abdominal aortic aneurysm A2, a thoracic aortic aneurysm, and a dissecting aortic aneurysm A3. In this specification and drawings, the front and rear sides of the implanted device 1 in the direction of insertion into the living body are referred to as the leading end and the trailing end, respectively.

[0017] As shown in FIGS. 1 to 2C, the implantation device 1 includes a tube 2, a cap 3, a plurality of markers 4, a porous body 5, and a fluid 6.

[0018] The tube 2 is a tubular portion. The tube 2 is biocompatible, chemically stable, and flexible. The tube 2 has slightly lower X-ray transparency than blood vessels. The tube 2 is made of a polymer. Specific examples of polymers that make up the tube 2 include polytetrafluoroethylene, polyamide, silicone, polyvinyl chloride, polyurethane, polyethylene, and polyglycerin. The polymer that makes up the tube 2 may be biodegradable, for example. For convenience of illustration, FIG. 1 shows the in-vivo indwelling device 1 in which the tube 2 is generally linear, but the in-vivo indwelling device 1 may be distributed or stored in a state in which the tube 2 is spirally wound, for example.

[0019] As shown in FIGS. 2A to 2C, the tube 2 is a porous body. That is, a plurality of holes 22 are formed in the side wall 21 of the tube 2. The side wall 21 of the tube 2 is a wall that continues around the central axis of the tube 2. A specific example of a porous body is a foam formed by heating and foaming a mixture of a polymer and a foaming agent. Another specific example of a porous body is a fiber array formed by arranging fibrous polymers in a three-dimensional network and welding them to each other. In the tube 2, each of the plurality of holes 22 may be formed, for example, so as to communicate with adjacent holes 22, or so as not to communicate with adjacent holes 22.

[0020] As shown in Figures 1 and 2A, the cap 3 is a component that closes the tip of the tube 2. Of the openings 23a, 23b at both ends in the axial direction of the tube 2, the cap 3 is large enough to cover the tip-side opening 23a. The cap 3 is attached to the tip-side opening 23a. The surface of the cap 3 opposite the tube 2 side is curved so as to bulge outward. The surface of the cap 3 opposite the tube 2 side forms the outer surface of the tip side of the implanted device 1 (i.e., the tip surface of the implanted device 1).

[0021] The cap 3 has a different X-ray transparency than the tube 2. Specifically, the cap 3 has a lower X-ray transparency than the tube 2. Therefore, the cap 3 has a lower X-ray transparency than a blood vessel. The cap 3 is made of, for example, a metal. Specific examples of metals that make up the cap 3 include platinum, gold, silver, palladium, tantalum, tungsten, and alloys thereof. The cap 3 of this embodiment is made of platinum.

[0022] As shown in Figures 1 and 2B, the multiple markers 4 are provided on the side wall 21 of the tube 2. The multiple markers 4 are provided at predetermined intervals from one another in the axial direction of the tube 2. The multiple markers 4 have a different X-ray transparency than the tube 2. Specifically, the multiple markers 4 have a lower X-ray transparency than the tube 2. Therefore, the multiple markers 4 have a lower X-ray transparency than blood vessels. The multiple markers 4 are made of, for example, a metal. Specific examples of metals that make up the multiple markers 4 include the metals exemplified as metals that make up the cap 3. The multiple markers 4 in this embodiment are made of platinum.

[0023] As shown in FIGS. 2A to 2C, the porous body 5 is a region in which a plurality of pores 51 are formed. The porous body 5 has biocompatibility, chemical stability, and flexibility. The porous body 5 has, for example, the same X-ray transparency as the tube 2. The porous body 5 is made of, for example, a polymer. Specific examples of the polymer that constitutes the porous body 5 include the polymers exemplified as the polymer that constitutes the tube 2. The porous body 5 is, for example, a foam formed by heating a mixture of a polymer and a foaming agent. Alternatively, the porous body 5 is, for example, a fiber array formed by arranging fibrous polymers in a three-dimensional network and welding them to each other. In the porous body 5, the plurality of pores 51 may be formed, for example, so as to communicate with adjacent pores 51, or so as not to communicate with adjacent pores 51.

[0024] The porous body 5 is disposed inside the tube 2. The porous body 5 is disposed, for example, so as to be continuous from the front end to the rear end of the tube 2. For example, the plurality of pores 51 in the porous body 5 are larger than the plurality of pores 22 in the tube 2.

[0025] The fluid 6 has fluidity. The fluid 6 has a different X-ray transparency than the tube 2. Specifically, the fluid 6 has a lower X-ray transparency than the tube 2. Therefore, the fluid 6 has a lower X-ray transparency than blood vessels. The fluid 6 is, for example, a liquid contrast medium. Specific examples of liquid contrast medium include iodine contrast medium and barium.

[0026] The fluid 6 is placed in the tube 2. Specifically, the fluid 6 is impregnated into the porous body 5 arranged inside the tube 2. When the fluid 6 is impregnated into the porous body 5, the fluid 6 enters the multiple pores 51 in the porous body 5 and is held by the porous body 5. However, since the fluid 6 has fluidity, it can flow out of the multiple pores 51 in the porous body 5. The fluid 6 that has flowed out of the multiple pores 51 passes through the multiple pores 22 in the tube 2 and flows out of the in-vivo indwelling device 1.

[0027] [2. Effect] The function of the implanted device 1 when used in embolization of cerebral aneurysm A1 will be described below with reference to FIGS. 3A to 3C.

[0028] First, as shown in FIG. 3A, the implanted device 1 is inserted into a known catheter C inserted into a blood vessel V under X-ray fluoroscopy. The implanted device 1 is inserted into the catheter C with the distal end of the tube 2 (i.e., the cap 3 side) in the lead position. The implanted device 1 is then advanced through the catheter C to the cerebral aneurysm A1. As described above, the implanted device 1 has a fluid 6 placed in the tube 2, which has lower X-ray transparency than the tube 2. For this reason, the tube 2 tends to appear dark in X-ray images due to the fluid 6 inside. This makes it easy for a doctor to visualize the tube 2 under X-ray fluoroscopy.

[0029] Furthermore, a cap 3 is attached to the tip of the tube 2 in the in-vivo indwelling device 1. The cap 3 has lower X-ray transparency than the tube 2. Therefore, the tip of the tube 2 tends to appear darker in X-ray images due to the cap 3. This makes it particularly easy for a doctor to visually confirm the tip of the tube 2 under X-ray fluoroscopy. This in turn makes it easier for a doctor to determine whether the tip of the tube 2 has reached the cerebral aneurysm A1.

[0030] Furthermore, as shown in Figures 2A to 2C, the in-vivo indwelling device 1 has a plurality of holes 22 formed in the side wall 21 of the tube 2. The fluid 6 impregnated in the porous body 5 flows out (e.g., seeps out) from the plurality of holes 22 to the outside of the in-vivo indwelling device 1. For this reason, in X-ray images, the side wall 21 of the tube 2 tends to appear darker due to the outflowing fluid 6. Therefore, the outflowing fluid 6 makes it particularly easy for a doctor to visually recognize the side wall 21 of the tube 2.

[0031] During surgery, for example, fluid 6 may be added to the inside of tube 2 from opening 23b on the rear end side of tube 2 depending on the amount of fluid 6 flowing out from multiple holes 22 in tube 2.

[0032] Next, as shown in FIG. 3B, the implanted device 1 is inserted into the cerebral aneurysm A1. As described above, multiple markers 4 are provided at predetermined intervals on the side wall 21 of the tube 2. The multiple markers 4 have lower X-ray transparency than the tube 2, and therefore tend to appear darker in X-ray images. This makes it easy for a physician to determine the length of the inserted tube 2 under X-ray fluoroscopy. After the implanted device 1 is inserted into the cerebral aneurysm A1 to the length of the tube 2 that will fill the interior of the cerebral aneurysm A1, it is cut to that length. A new rear opening 23b is formed in the cut end of the tube 2.

[0033] In this way, as shown in Fig. 3C, the inside of the cerebral aneurysm A1 is embolized by the implanted device 1. Thereafter, the embolization procedure is completed by a known procedure.

[0034] During and after the procedure, the fluid 6 continues to flow out from the multiple holes 22 and the rear end opening 23b of the tube 2 into the blood flowing through the blood vessel V. The fluid 6 that has flowed out into the blood is excreted from the body as urine by the kidneys. After a certain period of time has passed since the embolization procedure, almost no fluid 6 remains in the in-vivo indwelling device 1 that has been placed in the body.

[0035] In an examination using X-rays, the path length for X-rays to pass through the implanted device 1 is calculated as the sum of the thicknesses of each component of the implanted device 1 in the direction of X-ray irradiation. When the fluid 6 flows out of the tube 2, the path length for X-rays to pass through the implanted device 1 is shortened by the thickness of the outflowing fluid 6. This makes it easier for X-rays to pass through the implanted device 1. In other words, the implanted device 1 is less likely to obstruct the passage of X-rays. This prevents the implanted device 1 from interfering with the examination using X-rays.

[0036] In particular, in this embodiment, the fluid 6 has lower X-ray transparency than the tube 2. Therefore, when the fluid 6 flows out of the tube 2, the atomic density of the implanted device 1 as a whole is likely to decrease. Therefore, the implanted device 1 is even less likely to obstruct the transmission of X-rays. As a result, the implanted device 1 is even more unlikely to interfere with examinations using X-rays.

[0037] The above describes an example in which the implantable device 1 is applied to a cerebral aneurysm A1. In addition, the implantable device 1 can also be applied to, for example, an abdominal aortic aneurysm A2 shown in Fig. 4, a thoracic aortic aneurysm (not shown), and a dissecting aortic aneurysm A3 shown in Fig. 5. Figs. 4 and 5 show a state in which a known stent S has been placed in a blood vessel V across the abdominal aortic aneurysm A2 or dissecting aortic aneurysm A3, and the implantable device 1 has been inserted into the abdominal aortic aneurysm A2 or dissecting aortic aneurysm A3.

[0038] Abdominal aortic aneurysms A2, thoracic aortic aneurysms, and dissecting aortic aneurysms A3 generally have a volume approximately 1,000 times larger than that of cerebral aneurysms A1. When the volume of an aneurysm is large, the length of the implantable device 1 required to fill the aneurysm increases. Even in such cases, the fluid 6 flows out of the tube 2 into the blood flowing through the blood vessel V, and after a certain period of time has passed since embolization, almost no fluid remains in the implantable device 1. Even when the length of the device implanted in the body increases, the implantable device 1 is prevented from interfering with X-ray examinations.

[0039] [3.Effects] According to the embodiment described above in detail, the following effects can be obtained.

[0040] (3a) In general embolization, an embolic coil such as that described in Patent Document 1 is used. Embolic coils generally have low X-ray transparency and therefore tend to obstruct the passage of X-rays when placed inside a living body. Therefore, the embolic coil tends to appear dark in X-ray images, making it difficult to observe areas inside the living body that overlap with the embolic coil. In other words, when placed inside a living body, the embolic coil tends to interfere with X-ray examinations.

[0041] In contrast, the in-vivo implantation device 1 comprises a tube 2 and a fluid 6. The fluid 6 has fluidity and X-ray transparency different from that of the tube 2. The fluid 6 is contained in the tube 2. With this configuration, when the in-vivo implantation device 1 is implanted in a living body, the fluid 6 can be made to flow out of the tube 2 from the in-vivo implantation device 1. This shortens the path length for X-rays to pass through the in-vivo implantation device 1. This prevents the in-vivo implantation device 1 from blocking the transmission of X-rays. As a result, the in-vivo implantation device 1 can be prevented from interfering with examinations using X-rays.

[0042] (3b) The fluid 6 has lower X-ray transparency than the tube 2. With this configuration, when the in-vivo implantation device 1 is implanted in a living body, the fluid 6 flows out of the tube 2, which makes it easier to reduce the atomic density of the entire in-vivo implantation device 1. This further reduces the in-vivo implantation device 1 from blocking the transmission of X-rays. As a result, it is further reduced the interference of the in-vivo implantation device 1 with examinations using X-rays.

[0043] (3c) In the implanted device 1, a plurality of holes 22 are formed in the side wall 21 of the tube 2. With this configuration, the fluid 6 can flow out from the plurality of holes 22 during the process of implanting the implanted device 1 in a living body. This improves the visibility of the tube 2 under X-ray fluoroscopy during surgery.

[0044] Furthermore, with the above-described configuration, the fluid 6 can be made to flow out of the in-vivo implantation device 1 more quickly than with a configuration in which the side wall 21 of the tube 2 does not have multiple holes 22. Therefore, after the in-vivo implantation device 1 is placed in a living body, the effect of preventing the in-vivo implantation device 1 from interfering with examinations using X-rays can be obtained in a shorter period of time.

[0045] (3d) In the in-vivo implantation device 1, the tip of the tube 2 is closed. With this configuration, the visibility of the tip of the tube 2 under X-ray fluoroscopy can be improved in the process of implanting the in-vivo implantation device 1 in a living body, compared to a configuration in which the tip of the tube 2 is open. This is because the fluid 6 does not flow out from the tip of the tube 2, which prevents the tip of the tube 2 from appearing blurred in an X-ray image.

[0046] (3e) In the implanted device 1, a porous body 5 is disposed inside the tube 2. The porous body 5 is impregnated with a fluid 6.

[0047] This configuration can reduce the outflow rate of the fluid 6 from the tube 2. Therefore, for example, when a plurality of holes 22 are formed in the sidewall 21 of the tube 2 as in this embodiment, it is possible to prevent the fluid 6 from overflowing from the plurality of holes 22 during the process of placing the implanted device 1 in the living body. Therefore, it is possible to easily maintain the visibility of the tube 2 under X-ray fluoroscopy without adding fluid 6 during surgery.

[0048] (3f) In this embodiment, the tube 2 is made of a polymer. With this configuration, the atomic density of the entire in-vivo implantation device 1 after the fluid 6 has flowed out can be further reduced compared to, for example, a configuration in which the tube 2 is made of metal. Therefore, the in-vivo implantation device 1 can be further prevented from blocking the transmission of X-rays. As a result, the in-vivo implantation device 1 can be further prevented from interfering with examinations using X-rays.

[0049] Furthermore, with the above-described configuration, the tube 2 can be manufactured by injection molding. Therefore, the tube 2 can be manufactured relatively easily. As a result, it is easy to manufacture tubes 2 with different outer diameters, lumen shapes, or volumes, for example. For example, the outer diameter, lumen shape, or volume of the tube 2 may be appropriately set depending on the site in the living body where the in-vivo indwelling device 1 is to be placed.

[0050] (3g) In the in-vivo implantation device 1, the surface of the cap 3 opposite to the tube 2 side is curved so as to bulge outward. That is, the distal end surface of the in-vivo implantation device 1 is curved so as to bulge outward. With this configuration, it is possible to prevent damage to tissues inside the body when the in-vivo implantation device 1 is inserted into the body.

[0051] 4. Other Embodiments Although the embodiments of the present disclosure have been described above, it goes without saying that the present disclosure is not limited to the above-described embodiments and can take on various forms.

[0052] (4a) In the above embodiment, the fluid 6 is placed in the tube 2. At this time, for example, a selective therapeutic agent may be placed in the tube 2 together with the fluid 6. Specific examples of the selective therapeutic agent include antihyperlipidemic agents (e.g., statins), thrombosis promoters (e.g., thrombin), and fibrosis promoters (e.g., bFGF). With this configuration, when the in-vivo indwelling device is placed in a living body, the selective therapeutic agent can be discharged from the in-vivo indwelling device together with the fluid 6. This makes it easier for the selective therapeutic agent to act on the target site in the living body.

[0053] Furthermore, for example, when the porous body 5 is disposed inside the tube 2 as in the above embodiment and the selective therapeutic agent is impregnated into the porous body 5 together with the fluid 6, it becomes possible to enhance the sustained release of the selective therapeutic agent. The sustained release of the selective therapeutic agent can be controlled by appropriately adjusting the number and size of the plurality of holes 22 in the tube 2, the shape and volume of the lumen, and the number and size of the plurality of holes 51 in the porous body 5.

[0054] (4b) In the implanted device 1 of the above embodiment, the fluid 6 is impregnated into the porous body 5. In the manufacturing process of such an implanted device 1, the order of placing the porous body 5 inside the tube 2 and impregnating the porous body 5 with the fluid 6 is not particularly limited.

[0055] (4c) In the above embodiment, the implanted device 1 includes a porous body 5. However, as shown in Fig. 6, the implanted device 1A does not necessarily have to include a porous body 5. That is, the fluid 6 may be placed in the tube 2 in a state where it is impregnated in the porous body 5, or may be placed directly in the tube 2. Although Fig. 6 shows an example in which the tube 2 is filled with the fluid 6, the fluid 6 does not necessarily have to be placed in the tube 2 without any gaps.

[0056] (4d) In the above embodiment, the fluid 6 has lower X-ray transparency than the tube 2. However, the fluid may have, for example, higher X-ray transparency than the tube 2. For example, the fluid may have higher X-ray transparency than a blood vessel. Specific examples of such fluids include gases such as air and carbon dioxide. In other words, the fluid is not limited to a liquid as in the above embodiment, and may be, for example, a gas.

[0057] When gas is used as the fluid, the tube 2 tends to appear bright under X-ray fluoroscopy during surgery due to the gas as the fluid inside. This makes it easy for doctors to see the tube 2 under X-ray fluoroscopy. On the other hand, after surgery, when the gas as the fluid has flowed out of the tube 2, the implanted device does not easily obstruct the transmission of X-rays, as in the above embodiment. Therefore, even when gas is used as the fluid, the same effect as in (3a) above can be obtained.

[0058] (4e) In the above embodiment, the tip of the tube 2 is closed by attaching the cap 3 to the opening 23a on the tip side of the tube 2. However, the manner in which the tip of the tube 2 is closed is not limited to the cap 3. For example, as in the in-vivo implantation device 1B shown in FIG. 7, the tube 2B itself may be formed as a bottomed tube with a closed tip. In this case, it is preferable that the outer surface of the tip side of the tube 2B is formed as a curved surface that bulges outward. With this configuration, the same effect as in (3g) above can be obtained.

[0059] (4f) For example, the tip of the tube does not necessarily have to be closed. That is, the tube may have both the tip and the rear end open. This configuration allows the fluid to flow out of the in-vivo indwelling device more quickly. Therefore, after the in-vivo indwelling device is placed in the living body, the effect of preventing the in-vivo indwelling device 1 from interfering with examinations using X-rays can be obtained in a shorter period of time.

[0060] (4g) In the above embodiment, the tube 2 is porous, but the tube does not necessarily have to be porous. In other words, the side wall of the tube does not necessarily have to have multiple holes formed therein.

[0061] (4h) The material of the tube is not particularly limited. The tube may be made of, for example, a polymer as in the above embodiment, or may be made of a metal. When the tube is made of a metal, it is preferable that the metal has relatively high X-ray transparency among metals. Specific examples of metals that can be used to make the tube include aluminum, stainless steel, nickel-titanium alloy, and cobalt-chromium alloy.

[0062] (4i) In the above embodiment, a plurality of markers 4 are provided on the tube 2. However, the markers 4 do not necessarily have to be provided on the tube.

[0063] (4j) The function of one component in the above embodiments may be distributed among multiple components, or the functions of multiple components may be integrated into one component. Also, part of the configuration of the above embodiments may be omitted. Furthermore, at least part of the configuration of the above embodiments may be added to or substituted for the configuration of another of the above embodiments.

[0064] [Technical idea disclosed in this specification] [Item 1] A tubular tube; a fluid having flowability and X-ray transparency different from that of the tube and contained in the tube; The implantable device comprises:

[0065] [Item 2] The implantable device according to item 1, The fluid has lower X-ray transparency than the tube.

[0066] [Item 3] The implantable device according to item 1 or 2, The tube has a side wall formed with a plurality of holes.

[0067] [Item 4] The implantable device according to any one of items 1 to 3, The distal end of the tube is closed.

[0068] [Item 5] The implantable device according to any one of items 1 to 4, The fluid is a liquid contrast agent.

[0069] [Item 6] Item 6. The implantable device according to item 5, A porous body having a plurality of holes formed therein and disposed inside the tube is further provided. The fluid is impregnated into the porous body.

[0070] [Item 7] The implantable device according to any one of items 1 to 6, The tube is made of a polymer. [Explanation of symbols]

[0071] 1...in vivo placement component, 2...tube, 3...cap, 4...marker, 5...porous body, 6...fluid, 22,51...hole, A1...cerebral aneurysm, A2...abdominal aortic aneurysm, A3...dissecting aortic aneurysm, C...catheter, S...stent, V...blood vessel.

Claims

1. A tubular tube; a fluid having flowability and X-ray transparency different from that of the tube and contained in the tube; The implantable device comprises:

2. The implantable device according to claim 1, The fluid has lower X-ray transmittance than the tube.

3. The implantable device according to claim 1 or 2, The tube has a side wall formed with a plurality of holes.

4. The implantable device according to claim 1 or 2, The distal end of the tube is closed.

5. The implantable device according to claim 1 or 2, The fluid is a liquid contrast agent.

6. The implantable device according to claim 5, A porous body having a plurality of holes formed therein and disposed inside the tube is further provided. The fluid is impregnated into the porous body.

7. The implantable device according to claim 1 or 2, The tube is made of a polymer.

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