Drug delivery device incorporating electrical system contamination protection, power source management, power source monitoring, and / or power source operation

Abstract

To provide a drug administration device configured to administer a drug.SOLUTION: The drug administration device includes first and second housing electrical contacts, a dispensing mechanism, a drug holder, a removable power supply including first and second power supply electrical contacts, and at least one protection mechanism in a first protecting configuration when the removable power supply is not received within the housing and in a second configuration when the removable power supply is received within the housing. In another exemplary embodiment the drug administration device includes a housing, a dispensing mechanism disposed within the housing, a removable power supply that is configured to be received within the housing, a sensor configured to determine remaining charge of the removable power supply, and a processor configured to modify operation of the drug administration device in response to data produced by the sensor.SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] FIELD OF THE INVENTION The embodiments described herein generally relate to devices for administering medication. The disclosure further provides a drug delivery device that employs anti-contamination protection, power management, power monitoring, and / or power manipulation. Regarding the vise. [Background technology]

[0002] Pharmaceutical products (including large molecule and small molecule drugs, hereinafter referred to as "drugs") are used for specific medical indications. For treatment, drugs may be administered to patients in a variety of different ways. Regardless of the mode of administration, Care must be taken when administering drugs to avoid adverse effects. Care must be taken to ensure that patients are not given more than is necessary. The amount of dose received and how the dose is sometimes delivered relative to previous doses or doses of other drugs. Furthermore, the time frame in which the drug is used must be considered. Care must be taken to avoid inadvertently administering degraded drugs to patients. All of these considerations are conveyed in the guidance associated with a particular drug or drug combination. However, this guidance may be necessary due to mistakes, for example, human error. This can lead to adverse patient outcomes or inappropriate drug administration. This may result in, for example, insufficient or excessive volumes for a particular medical indication. Medication is administered.

[0003] It is further desirable that the drug delivery device be suitable for use in a variety of environments. Many environments in which a drug delivery device may need to be used contain moisture. Moisture contamination can also cause malfunction of the electrical components of the drug delivery device. This can lead to incorrect drug administration by the dispensing mechanism of the administration device. The device must be protected from moisture contamination and the user must be careful not to administer contaminated medication. It would be desirable to provide a drug delivery device that prevents this.

[0004] Furthermore, if the drug delivery device operates, it may not have enough power to successfully deliver the drug. This may not be possible, which could result in harm to the patient. Summary of the Invention [Means for solving the problem]

[0005] In a first aspect, there is provided a drug administration device configured to administer a drug, In an embodiment, the drug delivery device is a housing, the housing comprising a first housing a housing including a first electrical contact and a second electrical contact; and a dispensing mechanism configured to dispose the dispensing mechanism within a housing; a medication holder configured to hold a medication; and a medication administration device configured to power the medication administration device. a removable power source configured to include a first power supply electrical contact and a second power supply electrical contact; and (a) a housing for (i) removing the power source; The first housing electrical contact is maintained when the removable power source is not received within the housing. (ii) a removable power source is disposed within the housing; When received, the first and second housing electrical contacts and the first and second power supply electrical contacts a second configuration configured to allow contact between the points, respectively; and / or (b) the removable power source includes a housing protection mechanism that is (i) removable and a second power supply electrical contact for protecting the second power supply electrical contact when the power supply is not received within the housing. (ii) a removable power source is received within the housing; When the first and second housing electrical contacts are connected to the first and second power supply electrical contacts, a power supply protection device configured to be in a second configuration configured to respectively enable contact with the Includes structure.

[0006] The drug delivery device may have any number of variations. For example, the housing may be a housing The removable power supply may include a removable power supply protection mechanism, and / or Alternatively, the housing protection mechanism in the first configuration may include a seal around the first housing electrical contact. In at least some embodiments, the housing protector in the first configuration may The structure may form a seal around the second housing electrical contact and / or provide housing protection. The mechanism may include a membrane, the first power supply electrical contact, the power supply being a removable power supply received within the housing. The membrane may be configured to penetrate the membrane such that when the membrane is in the second configuration. In at least some embodiments, the first power electrical contact and the second power electrical contact are detachable. a second configuration when the membrane is received within the housing; Each of the above can be configured to:

[0007] In another example, the power supply protection mechanism in the first configuration includes a seal around the second power supply electrical contact. In at least some embodiments, the power protection mechanism in the first configuration may be A seal may be formed around one power supply electrical contact and / or the power supply protection mechanism may be a membrane, The two housing electrical contacts are connected to the membrane when the removable power source is received within the housing. At least some of the electrodes may be configured to penetrate the membrane so that the electrodes are in the second configuration. In an embodiment, the first housing electrical contact is connected to a removable power source received within the housing. The membrane may be configured to penetrate the membrane such that when the membrane is in the second configuration.

[0008] In yet another example, the housing protection mechanism in the first configuration comprises: a first housing electrical contact; and the power supply protection mechanism in the first configuration may form a seal around the second power supply electrical contact. In at least some embodiments, the housing protection mechanism and Each of the power protection mechanisms includes a membrane, a first power supply electrical contact, and a second housing electrical contact. each membrane in a second configuration when the removable power source is received within the housing; , each configured to penetrate a corresponding membrane.

[0009] In yet another example, the housing protection mechanism may be configured to protect the removable power supply when inserted into the housing. When the power supply is turned on, the device moves from the first configuration to the second configuration by contacting the removable power source. In at least some embodiments, the housing protection mechanism may be configured to The electrical contacts may be configured to move along the surface of one housing electrical contact. In some embodiments, the housing protection mechanism is adapted to change from a first configuration to a second configuration. When moving to the configuration, the second housing is configured to move along a surface of the electrical contact. It is possible.

[0010] In another example, the power supply protection mechanism may be configured to protect the hard drive when the removable power supply is inserted into the housing. configured to move from the first configuration to the second configuration upon contact with the housing. In at least some embodiments, the power supply protection mechanism comprises a surface of the first power supply electrical contact. In at least some embodiments, the power protection mechanism may be configured to move along the The mechanism includes a second power electrical contact when the power protection mechanism moves from the first configuration to the second configuration. The sensor may be configured to move along the surface of the sensor.

[0011] In yet another example, a first housing electrical contact, a second housing electrical contact, a first power source, At least one of the electrical contact and the second power supply electrical contact is provided with a hydrophobic conductive coating. The material may be coated with a coating.

[0012] In yet another example, the medication delivery device may be configured to detect an environmental parameter within the housing. The device may include at least one sensor located within a housing configured to receive medication. The device receives data from at least one sensor and a processor configured to modify operation of the medication administration device in response to the received data. In at least some embodiments, the at least one sensor may include a moisture sensor. may include a temperature sensor, a contamination sensor (e.g., a moisture sensor or a light sensor), In at least some embodiments, the processor receives from the at least one sensor. In response to the received data, (a) initiating limp mode operation, The mode operation includes a reduced function when a contaminant is determined to be present; ) indicating to the user the status of the drug delivery device; and (c) determining whether a contaminant is present. sometimes preventing the drug delivery device from starting, and / or (d) the presence of contaminants. and when it is determined that the medication administration device is In at least some embodiments, at least one The sensor may include a moisture sensor, and the processor may detect from the moisture sensor that moisture contamination is present. and operating the medication administration device upon receiving data indicating that a In at least some embodiments, at least one The sensors include a first moisture sensor at a first location within the housing and a second moisture sensor at a second location within the housing. and a second moisture sensor at a position. The processor may and receiving data from the moisture sensor and determining the location of moisture contamination within the housing from the data. The processor may be configured to: It may be configured to modify the operation of the drug administration device in different ways.

[0013] In yet another example, the housing may include conductive traces, and at least one sensor may The conductive trace may include a sensor configured to measure the conductivity of the conductive trace. In some embodiments, the conductive traces are positioned across the joints within the housing. It is possible.

[0014] In yet another example, the housing prevents electromagnetic radiation from interacting with the medication delivery device. The electromagnetic shield may be configured to:

[0015] In another example, the drug is infliximab, golimumab, ustekinumab, daratumumab , guselkumab, epoetin alfa, risperidone, and paliperidone palmitate It may include at least one of them.

[0016] In another embodiment, the drug administration device configured to administer a drug comprises a housing and a dispensing mechanism configured to dispense the medication, the dispensing mechanism being disposed within the housing. a dispensing mechanism, a medication holder configured to hold a medication, and a housing at least one located within the housing configured to detect an environmental parameter within the housing; and a processor, wherein the processor receives data from the at least one sensor. and controlling the operation of the medication administration device in response to the data received from the at least one sensor. and a processor configured to modify the operation.

[0017] The drug administration device may have any number of variations, such as at least one sensor. may include at least one contamination sensor. At least one contamination sensor may include a moisture sensor or an optical sensor. The processor may be configured to detect light from the light sensor, and the processor may be configured to perform a process based on the data received from the light sensor. Based on the detected contaminant, the medication holder may be configured to determine whether the medication holder contains a contaminant. The filter is transparent to at least the wavelengths of light that the optical sensor is configured to detect. The medication administration device may include a light source configured to illuminate the medication holder; The light sensor may be configured to detect light from the light source after the light passes through the medication holder. do.

[0018] In yet another example, the processor is responsive to data received from the at least one sensor. (a) initiating limp mode operation, the limp mode operation being performed when the contaminants (b) comprising a reduced function when determined to be present; (c) indicating the status to the user when a contaminant is determined to be present; and / or (d) preventing the chair from starting when it is determined that a contaminant is present. configured to modify operation of the medication administration device by communicating with a remote server It can be done.

[0019] In yet another example, the at least one sensor may include a moisture sensor, and the processor The processor receives data from the moisture sensor indicating that moisture contamination has been detected within the housing. The device may be configured to modify the operation of the medication administration device when

[0020] In another example, the at least one sensor may include a first moisture sensor at a first location within the housing. The sensor may include a second moisture sensor at a second location within the housing. In some embodiments, the processor receives the first moisture sensor and the second moisture sensor. and determining a location of moisture contamination within the housing from the data. The processor adjusts the medication delivery device in response to different locations of moisture contamination within the housing. may be configured to modify the operation of in different ways.

[0021] In yet another example, the housing may include conductive traces, and the at least one sensor may The conductive trace may include a sensor configured to measure the conductivity of the conductive trace. In some embodiments, the conductive traces are positioned across the joints within the housing. It is possible.

[0022] In yet another example, the housing prevents electromagnetic radiation from interacting with the medication delivery device. The electromagnetic shield may be configured to:

[0023] In another example, the drug is infliximab, golimumab, ustekinumab, daratumumab , guselkumab, epoetin alfa, risperidone, and paliperidone palmitate It may include at least one of them.

[0024] In another embodiment, the drug administration device configured to administer a drug comprises a housing and a dispensing mechanism configured to dispense the medication, the dispensing mechanism being disposed within the housing. a dispensing mechanism and a removable device configured to power the drug administration device; a power supply, the housing being configured to receive a removable power supply; a removable power source; and a first sensor, the first sensor detecting a remaining charge of the removable power source. a first sensor configured to measure a parameter and output data indicative of a processor, the processor receiving data from the first sensor; and configured to modify operation of the medication administration device in response to data received from the and a processor.

[0025] Drug delivery devices can vary in a number of ways. For example, the housing can The device may be configured to receive a second power source configured to power the substance dispensing device. In at least some embodiments, the drug administration device determines the remaining charge of the second power source. a second sensor configured to receive data from the second sensor; and modifying operation of the medication administration device in response to data received from the second sensor. In at least some embodiments, the second power source may be a primary cell. In at least some embodiments, the drug administration device includes a second power source. The second power source may be disposed within the housing. The second power source may be adapted to be charged wirelessly. The drug administration device may be configured such that a removable power source is received within the housing. The removable power source may be configured to charge the second power source when the second power source is connected to the removable power source. The power source may be configured to power the drug administration device for a predetermined period of time, and the power source may be a removable power source. may be configured to be chargeable from no charge to full charge within a predetermined period of time.

[0026] In another example, modifying the operation of the medication delivery device may involve determining the remaining charge of a removable power source. a processor configured to initiate an alert when the In yet another example, the processor may further include: In yet another example, a removable The power source may include removable power source identification data, and the processor may determine whether the removable power source is a home The removable power supply may be configured to receive removable power supply identification data when received within the housing. The processor modifies the operation of the medication administration device in response to the removable power source identification data. In another example, the removable power source may be configured to receive data. In yet another example, the distribution mechanism may be powered by a removable power source. The power supply may be configured to be electrically connected to the power supply.

[0027] In yet another example, the dispensing mechanism may include a device movement prevention mechanism. In this embodiment, the removable power source may include removable power source identification data, The removable power supply identification data is stored in the housing when the removable power supply is received in the housing. The removable power source identification data may be configured to receive the removable power source identification data, and the processor may be configured to , may be configured to modify the operation of the medication administration device, modifying the operation of the medication administration device The removable power supply identification data is used to identify whether the removable power supply is compatible with the medication administration device. The device operation prevention mechanism prevents the distribution mechanism from supplying power to the removable power source when the device indicates that it is not compatible. The device operation prevention mechanism may include preventing the device from being electrically disconnected. the distribution mechanism disconnects the removable power source when the remaining charge of the removable power source falls below a third threshold level. The third threshold level may be configured to prevent the power supply from being supplied by the distribution mechanism. may be sufficient charge to complete a full drug administration sequence.

[0028] In yet another example, the drug dispensing mechanism may be configured to be manually operated. In some embodiments, the dispensing mechanism includes a device motion prevention mechanism, The mechanism is configured to: when the remaining charge of the removable power source exceeds a fourth threshold level, the distribution mechanism It may be configured to prevent it from being manually operated.

[0029] In another example, the drug is infliximab, golimumab, ustekinumab, daratumumab , guselkumab, epoetin alfa, risperidone, and paliperidone palmitate It may include at least one of them. [Brief explanation of the drawings]

[0030] The present invention will now be described with reference to the accompanying figures in which: [Figure 1] 1 is a schematic diagram of a first type of drug administration device, namely an autoinjector. [Figure 2] 1 is a schematic diagram of a second type of drug administration device, namely an infusion pump. [Figure 3] FIG. 1 is a schematic diagram of a third type of drug administration device, namely an inhaler. [Figure 4] 1 is a schematic diagram of a typical drug delivery device. [Figure 5] FIG. 1 is a schematic diagram of a universal drug administration device. [Figure 6] FIG. 1 is a schematic diagram of the housing of the dosage form. [Figure 7] 1 is a schematic diagram of one embodiment of a communication network system in which the medication administration device and housing may operate. [Figure 8] FIG. 1 is a schematic diagram of one embodiment of a computer system in which the medication administration device and housing may operate. [Figure 9] 1 is a schematic diagram of an embodiment of a medication administration device with multiple sensors located within the housing. [Figure 10a] FIG. 2 is a schematic diagram of one embodiment of a housing protection mechanism in a first configuration. [Figure 10b] FIG. 10b is a schematic diagram of the embodiment of FIG. 10a with the housing protection mechanism in a second configuration. [Figure 11] FIG. 2 is a schematic diagram of one embodiment of a housing protection mechanism in a first configuration. [Figure 12] 1 is a schematic diagram of an embodiment of a medication administration device including a light source and an optical sensor configured to detect contamination within a medication housing. [Figure 13] FIG. 10 is a schematic diagram of another embodiment of a medication administration device that includes a dispensing mechanism that is both electronically and manually operable. DETAILED DESCRIPTION OF THE INVENTION

[0031] Principles of structure, function, manufacture, and use of the devices, systems, and methods disclosed herein To provide a general understanding of the present invention, certain exemplary embodiments will now be described. One or more examples of these embodiments are illustrated in the accompanying drawings. The devices, systems, and The methods are non-limiting exemplary embodiments, and the scope of the invention is defined only by the claims. It will be understood that the terms "interface" and "interfaces" are defined as follows: The features of any of the embodiments may be combined with those of other embodiments. are intended to be included within the scope of the present invention.

[0032] Furthermore, in this disclosure, like-named components of the embodiments generally have similar characteristics. Therefore, in certain embodiments, each feature of each similarly named component may be In addition, the disclosed system, To the extent that linear or circular dimensions are used in describing devices and methods, such dimensions The present invention relates to a variety of shapes that can be used in conjunction with such systems, devices, and methods. The present invention is not intended to limit the scope of the present invention. Those skilled in the art will appreciate that such a direct It will be appreciated that the equivalent linear and circular dimensions can be readily determined. Those skilled in the art will recognize that even if the dimensions are not exact values, various factors such as manufacturing tolerances and the sensitivity of measuring equipment will be taken into account. It will be understood that the value is likely to be close to that value due to the reasons. The size and shape of the devices and their components are The size and shape of the components may depend at least on the size and shape of the components.

[0033] Regarding how the drug is administered to the patient, there are various dosage forms that can be used. For example, these dosage forms may include parenteral, inhaled, oral, ophthalmic, topical, and / or topical administration of one or more drugs. It may include the form of a suppository.

[0034] The dosage form may be administered directly to a patient via a drug administration device. (e.g., autoinjectors, jet injectors, and infusion pumps), and inhalers Many different types of drug administration devices are commonly available for the delivery of various dosage forms, including exists.

[0035] It is desirable to monitor compliance with the guidance associated with drugs administered to patients in various dosage forms. This provides assurance that the correct procedures are being followed and This avoids the need for precise and potentially dangerous approaches. It may also be possible to optimize the administration of substances.

[0036] Any of a variety of drugs can be delivered using the drug administration devices described herein. Examples of drugs that can be delivered using this drug administration device include Remicade (registered trademark). Trademark) (infliximab), Stelara® (ustekinumab), Sim poni® (golimumab), Simponi Aria® (golimumab) Mab), Darzalex® (daratumumab), Tremfya® (guselkumab), Eprex® (epoetin alfa), Risperda Constra® (risperidone), Invega Sustenna® ® (paliperidone palmitate), and Invega Trinza ® ) (paliperidone palmitate).

[0037] Examples of various types of drug administration devices include an autoinjector 100, an injection port, The pump 200 and inhaler 300 are described below with reference to the above referenced figures.

[0038] autoinjector FIG. 1 illustrates a first type of drug delivery device that can be used in the embodiments described herein. 1 is a schematic, illustrative diagram of an injection device, in this example, an autoinjector 100. The autoinjector 100 includes a drug holder 110 that holds the drug to be dispensed, and a drug dispenser 112 that dispenses the drug. The device is configured to dispense the medication from the medication holder 110 so that the medication can be administered to the patient. and a dispensing mechanism 120 for dispensing the drug. The drug holder 110 is typically a container for containing the drug. For example, the medication holder 110 may be provided in the form of a syringe or a vial. or any other suitable container capable of holding a drug. 100 includes a discharge nozzle 122, e.g., a syringe, provided at the distal end of the medication holder 110. The dispensing mechanism 120 includes a drive element 124, which itself also includes a piston. The dispensing mechanism 120 may include a piston and / or a piston rod, and a drive mechanism 126. Located proximal to the end of object holder 110 and toward the proximal end of autoinjector 100 do.

[0039] The autoinjector 100 includes a housing 130, and the housing 130 includes a main body. The housing not only houses the medication holder 110, the drive element 124, and the drive mechanism 126, but also Prior to injection, the drug is typically contained entirely within the housing, but during the injection sequence, the drug is The housing also houses a discharge nozzle 122 that extends from the housing 130 for delivery. The dispensing mechanism 120 includes a nozzle 122 for dispensing the drug. , the drive element 124 is advanced through the medication holder 110, thereby causing the auto-injector The vector is adapted to allow the drug held in the drug holder 110 to be administered to the patient. In some cases, the user may drive the drive element 124 through the medication holder 110. Alternatively, the drive mechanism 126 may be manually advanced. The stored energy source 127 may include a stored energy source 127 for propelling the 124. or pressurized gas, or electronically powered motors and / or gearboxes A force member may be included.

[0040] Autoinjector 100 includes a dispensing mechanism protection mechanism 140. The dispense mechanism protector 140 typically has two functions. First, the dispense mechanism protector 140 protects the dispenser before and after injection. Second, the automatic injection may function to prevent access to the discharge nozzle 122 after injection. The injector 100 is armed, e.g., the dispense mechanism protection mechanism 140 is unlocked. When moved to the unloaded position, the dispensing mechanism 120 can function such that it can be activated.

[0041] The protection mechanism 140 prevents the medication holder 110 from being in a retracted position proximally within the housing 130. When the nozzle 122 is inserted, it covers at least a part of the nozzle 122. Alternatively or additionally, the protection mechanism 140 may be The body is configured to retract proximally to expose the discharge nozzle 122, such that: The discharge nozzle 122 can be brought into contact with a patient. The protection mechanism 140 includes a shield member 141. and a return spring 142. The return spring 142 is configured to support the shield member 141 in the housing. 130, so that when no force is applied to the distal end of the protection mechanism 140, When the user overcomes the bias of the return spring 142, the discharge nozzle 122 is covered. As shown, when a force is applied to the shield member 141 against the action of the return spring 142, the shield The hood member 141 retracts within the housing 130, thereby exposing the discharge nozzle 122. The protection mechanism 140 may alternatively or additionally protect the discharge nozzle from beyond the housing 130. An extension mechanism (not shown) may be provided to extend the nozzle 122 within the housing 130. The protection mechanism 140 may further include a retraction mechanism (not shown) for retracting the roller 122. Alternatively or additionally, a housing cap may be attached to the autoinjector 100. The housing cap may include a cap and / or a discharge nozzle boot. The discharge nozzle boot is also removed from the discharge nozzle 122.

[0042] The autoinjector 100 also includes a trigger 150. The trigger 150 on the exterior of the housing 130 so as to be accessible by a user of the projector 100. The trigger 150 is located at the Upon actuation, trigger 150 acts to release drive mechanism 126, resulting in drive element 124, the drug is then expelled from the drug holder 110 through the discharge nozzle 122. will be done.

[0043] Trigger 150 may also be used, for example, to press the distal end of shield member 141 against the patient's skin. By doing so, the shield member 141 is sufficiently proximally unlocked within the housing 130. The seal is secured in a manner that prevents the trigger 150 from being actuated until it is retracted to the release position. When this is done, trigger 150 is unlocked and the trigger The trigger 150 can then be depressed to initiate the injection and / or drug delivery sequence. Alternatively, the shield member 141 may be used alone. Retracting the drive mechanism 126 proximally into the housing 130 activates the drive mechanism 126, causing the injection and / or may act to initiate a drug delivery sequence. Injector 100 may be configured to prevent, for example, accidental release of dispensing mechanism 120 and / or trigger 15 Device activation prevention mechanism that prevents accidental activation of the device, thereby preventing drug dispensing. It has.

[0044] Although the above description relates to one example of an autoinjector, this example is provided purely for illustrative purposes. As presented, the present invention is not limited to only such autoinjectors. Those skilled in the art will appreciate that various modifications to the autoinjector described will be within the scope of this disclosure. Understand that it can be done.

[0045] The autoinjector of the present disclosure is capable of administering epinephrine, Rebif, Enbrel, Aran Various drugs such as esp, atropine, pralidoxime chloride, and diazepam It can be used to administer either

[0046] infusion pump In other situations, patients require precise continuous delivery of medication or regular doses at set periodic intervals. Infusion pumps can be used to administer medications to patients in a timely or frequent manner, either by a healthcare professional or by the patient. Facilitates administration of drugs at precise rates that keep drug concentrations within therapeutic limits without requiring careful attention Such controlled drug infusion can be provided by

[0047] FIG. 2 illustrates a second type of drug delivery device that can be used in the embodiments described herein. 2 is a schematic, exemplary diagram of an infusion pump 200. Infusion pump 200 delivers a drug holder 210 in the form of a reservoir for containing a drug and by which the drug may be delivered to the patient; and a pump 216 adapted to dispense the drug contained in the reservoir, such that and a dispensing mechanism 220. These components of the infusion pump are housed within a housing 230. The dispensing mechanism 220 further comprises an infusion line 212. The drug is delivered to the pump 216. In operation, fluid is delivered from the reservoir via an infusion line 212, which may take the form of a cannula. The pump 216 may be an elastomeric pump, a peristaltic pump, an osmotic pump, or a syringe pump. Typically, drugs are delivered intravenously, but Subcutaneous, intraarterial, and epidural injections may also be used.

[0048] The infusion pump of the present disclosure is capable of administering insulin, atropine sulfate, avibactam sodium, Bendamustine hydrochloride, carboplatin, daptomycin, epinephrine, levetiraceta oxaliplatin, paclitaxel, pantoprazole sodium, treprostin Any of a variety of drugs, including benzodiazepine, vasopressin, voriconazole, and zoledronic acid It can be used to administer either

[0049] The infusion pump 200 includes control circuitry, such as a memory 297 and a user interface 298. 80, further comprising a processor 296, which together control the trigger mechanism and / or The user interface 280 provides a dose selector for the pump 200. The control circuit may be implemented by a display screen located on the housing 230 of the pump 200. The path and user interface 280 may be located within the housing 230 or external to it. may communicate with the pump 216 via a wired or wireless interface to control its operation. do.

[0050] The operation of the pump 216 is controlled by a process that communicates with the pump 216 to control the operation of the pump. The user interface 280 is controlled by a processor 296. It can be programmed by a user (e.g., a patient or a medical professional) via the This allows the infusion pump 200 to deliver medication to the patient in a controlled manner. The user can input parameters such as injection duration and delivery rate. is typically pre-programmed by the user for a constant infusion rate or for periodic delivery. It can be set as a set interval within programmed limits. The programmed parameters are stored in a memory 297 in communication with the processor 296; The user interface 280 may be a touch screen or may take the form of a keypad.

[0051] Power supply 295 is an energy source that provides power to pump 216 and is integral with pump 216. and / or may take the form of a mechanism for connecting the pump 216 to an external power source.

[0052] Infusion pump 200 may take a variety of different physical forms depending on its intended use. Infusion pump 200 may be a fixed, non-portable device, for example, for use at a patient's bedside. may be a portable device or may be designed to be handheld or wearable. It may also be an infusion pump. The integrated power supply 295 is particularly useful for ambulatory infusion pumps.

[0053] Although the foregoing description relates to one example of an infusion pump, this example is provided purely for illustrative purposes. The present disclosure is not limited to such infusion pumps. Those skilled in the art will recognize that the infusion pumps described It will be understood that various modifications to the pump may be made within the scope of this disclosure. The processor is pre-programmed so that the infusion pump does not need to include a user interface. It may be rammed.

[0054] inhaler Figure 3 is a schematic diagram of a third type of drug delivery device, namely an inhaler 300. The container 300 includes a medication holder 310 in the form of a canister. Typically, the inhaler contains the drug in a solution or suspension using a suitable carrier liquid. 00 includes a pressurized gas for pressurizing the medication holder 310, a valve 325, and a nozzle 321. The medication holder 310 further includes a dispensing mechanism 320 including a valve 325 defining an outlet for the medication holder 310. The valve 325 is formed by a narrow opening 324 formed in the medication holder 310 and an opening and a movable element 326 that controls the movement of the moving element 324. When the movable element 326 is in the rest position, The valve 325 is in a closed state, in which the opening 324 is closed and the medication holder 310 is sealed, or When the movable element 326 is actuated from the rest position to the actuated position, the valve 32 5 is actuated to an open state in which the opening 324 is open. Actuation of the element 326 includes moving the movable element 326 into the medication holder 310. The moving element 326 is resiliently biased to a rest position. The drug in solution or suspension with a suitable liquid is then injected through opening 324. The high velocity of the liquid passing through the narrow opening 324 pushes the liquid out of the medication holder 310. The body is atomized, i.e., converted from the bulk liquid into a mist of fine droplets of liquid and / or gas. The patient may inhale a mist of fine droplets and / or a cloud of gas into the respiratory tract. Therefore, the inhaler 300 injects the drug held in the drug holder 310 into the patient's respiratory system. It can be delivered into the tract.

[0055] The medication holder 310 is removably held within the housing 330 of the inhaler 300. A passage 333 formed in the housing 330 is connected to a first opening 333 in the housing 330. 31 and a second opening 332 in the housing 330. The medication holder 310 is The medication holder 310 is received within the passage 333 of the housing 330. 1 and 3. The second opening in the housing 330 is slidably insertable into the passage 333 through the second opening in the housing 330. 332 is a mouthpiece 322 configured to be placed in the patient's mouth or nose a nosepiece configured to be placed within the bore or over the patient's mouth and nose; The mask is configured as follows: The medication holder 310, the first opening 331, and the passage 333 is a flow passage for allowing air to pass through the medication holder 31 between the first opening 331 and the second opening 332. The inhaler 300 is sized to allow the blood to flow through the passageway 333 at about 0. a dispensing mechanism protector 140 in the form of a cap (not shown) that can be fitted onto the dispenser 322; It may be prepared.

[0056] The inhaler 300 includes a trigger 350 that, when activated, activates a valve. trigger 350 including a valve actuation feature 355 configured to actuate valve 325. The valve actuation feature 355 protrudes from the housing 330 into the passage 333. The medication holder 310 is slidable within the passageway 333 from a first position to a second position. In the first position, the end of the movable element 326 in the rest position is movable in the direction of the valve actuation. In the second position, the medication holder 310 abuts the valve actuation feature 355. moves the movable element 326 into the medication holder 310 and actuates the valve 325 to an open state. The user's hand can be displaced toward the valve actuation feature 355 to actuate the drug dispenser. The roller 310 is moved from the first position to the second position against the resiliently biased movable element 326. The valve actuation feature 355 is connected to the nozzle 321 and provides the force necessary to move the valve actuation feature 355. The inlet 356 of the valve actuation feature 355 is connected to the ejected droplets. The mist and / or gas cloud enters the inlet 356 and exits through the nozzle 321 into the passageway 333. 325. The valve 325 is sized and positioned to mate with the opening 324 of the valve 325 so that the Nozzle 321 supports the atomization of bulk liquid into a mist of droplets and / or a gas cloud. Support.

[0057] Valve 325 provides a metering mechanism 370. Metering mechanism 370 dispenses a measured amount of liquid. , and is configured to close the valve after the drug has passed through opening 324. This allows a controlled dose to be administered to the patient. The measured volume of the body is preset, but the inhaler 300 varies the defined volume of the liquid. A user operable dose selector 360 may be provided so as to

[0058] Although the foregoing description relates to one particular example of an inhaler, this example is purely illustrative. The description should not be seen as being limited to only such inhalers. Those skilled in the art will recognize that many other types of inhalers and nebulizers may be used with the present disclosure. For example, can the drug be in powder form, can the drug be in liquid form, Alternatively, the drug may be delivered by other forms of delivery mechanisms including ultrasonic vibration, compressed gas, vibrating mesh, or a heat source. 320 can be atomized.

[0059] The inhaler of the present disclosure can be used to administer mometasone, fluticasone, ciclesonide, budesonide, beclomethasone, Tazone, vilanterol, salmeterol, formoterol, umeclidinium, glycol Copyrrolate, tiotropium, aclidinium, indacaterol, salmeterol, and olodaterol. do.

[0060] Drug Delivery Devices As will be appreciated from the foregoing, the various components of the drug delivery device are These components are common to all devices. The drug administration device delivers a drug to a patient, the drug being in a defined dosage form. provided in a drug administration device.

[0061] FIG. 4 is a generalized schematic diagram of such a universal drug delivery device 400. , FIG. 5 is an exemplary embodiment of such a universal drug administration device 500. .

[0062] As shown in FIG. 4, the drug delivery device 400, in its general form, The medication holder 10 includes features of a medication dispenser 10 and a dispensing mechanism 20. The medication holder 10 holds the medication in the dosage form to be administered. The dispensing mechanism 20 releases the dosage form from the medication holder 10 so that the medication can be administered to the patient. It is configured to output

[0063] FIG. 5 illustrates a further universal drug delivery device 500 that includes several additional features. Those skilled in the art will recognize that these additional features are optional for different embodiments and may be used in conjunction with other drug the type of drug, the drug dosage form, the medical indication being treated with the drug, safety requirements, whether the device is portable; whether the device is used for self-administration; Additional features may be added depending on requirements, such as whether the device is a may be present or may be omitted from a given embodiment of a particular drug administration device. , and can be utilized in a variety of different combinations. Similarly, the medication administration device 500 includes a housing that houses the medication holder 10 and the dispensing mechanism 20. Equipped with housing 30.

[0064] The device 500 is configured to initiate the release of the drug from the drug holder 10 by the dispensing mechanism 20. The device 500 includes a trigger mechanism 50 for dispensing the medication from the medication holder 1 via the dispensing mechanism 20. 0. The dispenser 70 includes a metering / dispensing mechanism 70 that measures the set dose released from the dispenser 70. , the drug delivery device 500 can provide a known dose of a determined size. 00 allows the user to set the dose volume of the drug to be measured by the metering mechanism 50. The dose volume is selected from a plurality of predetermined individual dose volumes. or any value of a given dose volume within a range of dose volumes. obtain.

[0065] The device 500 may include the device operation prevention mechanism 40 or 25. When the mechanism 40 or 25 is in the locked state, the dispensing mechanism 20 releases the drug from the drug holder 10. When in the unlocked state, the dispensing mechanism 20 prevents and / or stops the drug from being dispensed. This allows for the release of a drug dose from the holder 10, e.g. to prevent accidental administration of medication, to prevent administration in a hospital, or to prevent inadvertent actuation. The device 500 may also be configured to shut down the dispensing mechanism 20, e.g., for safety reasons. The device includes a dispensing mechanism protection mechanism 42 that prevents access to at least a portion of the device. The stop mechanism 40 and the dispensing mechanism protection mechanism 42 may be the same component.

[0066] The device 500 may provide information about the status of the drug delivery device and / or the drug contained therein. The device may include a device indicator 85 configured to present information related to the device. The indicator 85 may be a visual indicator, such as a display screen, or an audio indicator. The device 500 may present information about the device 500 to the user of the device 500. and / or configured to allow a user to control the device 500. The device 500 includes a user interface 80 that can be used to administer medication. and / or information relating to the drug contained therein, e.g., dosage form and device parameters. By way of example, the device sensor 92 may include a metering mechanism 70 and a throwing mechanism 92 configured to sense the In embodiments that include a dose selector 60, the embodiment may use the dose selector 60 to the dose selected by the user, the dose metered by the metering mechanism 70, and the dose One or more of the dispensed doses are configured to sense one or more of the dispensed doses. The device may further include two or more device sensors 92. Similarly, the device may include sensors for measuring the temperature of the environment, the humidity of the environment, ... The device 500 is configured to sense information about the environment in which the device 500 resides, such as location and time. Environmental sensors 94 are provided that are connected to the device via satellite positioning, for example GPS. a dedicated position sensor 98 configured to determine the geographic location of the device 500, The device 500 may also include various sensors related to the device and / or the drug. The device includes a communication interface 99 that can communicate data acquired from the device to the outside.

[0067] Optionally, device 500 may include one or more electrical components of device 500. The device 500 includes a power supply 95 for delivering power to the device. The power supply 95 is integral with the device 500. It may be a power source and / or a mechanism for connecting the device 500 to an external power source. The devices 500 are also powered by a power source 95 and communicate with each other and, optionally, with an environmental sensor. 94, position sensor 98, device sensor 92, communication interface 99, and / or The processor communicates with other electrical and control components of the device 500, such as the indicator 85. The device includes a computer system 90 including a processor 96 and a memory 97. 96 includes the environmental sensor 94, the device sensor 92, the communication interface 99, and the position sensor 98, and / or obtain data obtained from the user interface 80 and process it. and outputting data to, for example, the indicator 85 and / or the communication interface 99. It is configured to provide a force.

[0068] In some embodiments, the drug administration device 500 is sealed within packaging 35. The packaging 35 includes a processor 96, memory 98, and 7, user interface 80, device indicator 85, device sensor 92, position The device may further include a combination of position sensors 98, and / or environmental sensors 94, which may It may be located outside the housing of the sensor 500.

[0069] Those skilled in the art will appreciate that the universal medication delivery device 5 comprising the medication holder 10 and the dispensing mechanism 20 00 may have the various optional features described above in several different combinations. It will be appreciated that the medication delivery device 500 further includes a medication holder 504 associated with it. Optionally, two or more dispensing mechanisms 20 may be provided. More than one medication holder 10 may be included.

[0070] Drug dosage form Traditionally, drug delivery devices utilize liquid dosage forms. However, other dosage forms are available. It will be understood that this is possible.

[0071] One such common dosage form is the tablet. Tablets contain a drug and excipients compressed together. Other dosage forms include pastes, creams, ear drops, and drops. It is eye fluid.

[0072] Further examples of drug dosage forms include skin patches, drug-eluting stents, and intrauterine devices. In these examples, the body of the device contains a drug and releases the drug under certain conditions. For example, a skin patch may be constructed to allow the drug to be delivered to the skin. The polymer composition may comprise a composition that allows the drug to diffuse from the polymer composition into the patient's skin. Drug-eluting stents and intrauterine devices may operate in a similar manner. In this way, patches, stents, and intrauterine devices may themselves be associated with It can be thought of as a medication holder with a dispensing mechanism.

[0073] Any of these dosage forms may be configured to trigger drug release upon specific conditions. This allows the drug to be released at the desired time or location after the dosage form is introduced into the patient. In particular, drug release can be initiated by an external stimulus. The dosage form may be contained within a housing, which may be in the form of packaging, prior to administration. This housing may include any of the optional components described above that are utilized in the universal drug delivery device 500. It may include some of the features.

[0074] The drugs administered by the drug administration device of the present disclosure, when consumed, have physiological effects on the organism. or any substance that causes a mood change. Examples of drugs that can be used include 5-alpha-reductase inhibitors, 5-aminosalicylates, 5HT3 receptor antagonists, ACE inhibitors with calcium channel blockers, with thiazides ACE inhibitors, adamantane antivirals, corticosteroids, adrenal corticosteroids Adrenergic bronchodilators, emergency hypertension medications, pulmonary hypertension medications, Ludosterone receptor antagonist, alkylating agent, allergen, α-glucosidase inhibitor Medicines, alternative medicines, amoebicides, aminoglycosides, aminopenicillins, aminosalicylic acids, AMPA receptor antagonists, amylin analogs, analgesic combinations, analgesics, androgens and and anabolic steroids, angiotensin-converting enzyme inhibitors, and calcium channel blockers Angiotensin II inhibitors, angiotensin II inhibitors with thiazides, angiotensin II inhibitors angiotensin receptor blockers, angiotensin receptor blockers and neprilysin inhibitors, anorectal Pharmaceuticals, appetite suppressants, antacids, anthelmintics, anti-angiogenic ophthalmic agents, anti-CTLA-4 monoclonal Antibodies, anti-infectives, anti-PD-1 monoclonal antibodies, anti-adrenergic agents including thiazides (central), antiadrenergics including thiazides (peripheral), antiadrenergics, central acting, antiadrenergic, peripherally acting, antiandrogen, antianginal, antiarrhythmic, Antiasthmatic combinations, antibiotics / antineoplastics, anticholinergic antiemetics, anticholinergic anti Parkinson's agents, anticholinergic bronchodilators, anticholinergic chronotropic agents, anti Cholinergic / antispasmodic, anticoagulant reverser, anticoagulant, anticonvulsant, antidepressant, antidiabetic Antidiabetic drugs, antidiabetic combinations, antidiarrheals, antidiuretic hormones, antidotes, antiemetics / antivertigo drugs , antifungal, antigonadotropic, antigout, antihistamine, hypolipidemic, hypolipidemic Combination, combination of antihypertensive drugs, antihyperuricemia drugs, antimalarials, antimalarials Combination, antimalarial quinolone, antimanic, antimetabolite, antimigraine, antitumor drug combination Combined, antitumor drug antidote, antitumor drug interferon, antitumor drug, antiparkinson drug, anti Platelet inhibitors, antipseudomonal penicillins, antipsoriatic drugs, antipsychotics, antirheumatic drugs, antiseptics and Antiseptics, antithyroid drugs, antitoxins and antivenins, antituberculous drugs, antituberculous combination drugs, antitussives, Antiviral agents, antiviral boosters, antiviral combinations, antiviral inter Feron, anxiolytics, sedatives, and hypnotics, aromatase inhibitors, atypical antipsychotics, Antifungal drugs, bacterial vaccines, barbiturates, anticonvulsants, barbiturates, BCR -ABL tyrosine kinase inhibitors, benzodiazepine anticonvulsants, benzodiazepines, Beta-blockers, including calcium channel blockers; beta-blockers, including thiazides; beta-anticoagulants Adrenergic blockers, beta-lactamase inhibitors, bile acid sequestrants, biologics, bisphosphatase inhibitors phonates, bone morphogenetic proteins, bone resorption inhibitors, bronchodilator combinations, bronchodilators , calcium receptor agonists, calcineurin inhibitors, calcitonin, calcium channels blockers, carbamate anticonvulsants, carbapenems, carbapenem / beta-lactams Anticonvulsants, carbonic anhydrase inhibitors, cardiac stress agents, cardiac Selective beta-blockers, cardiovascular agents, catecholamines, cation exchange resins, CD20 monoclonal antibodies monoclonal antibody, CD30 monoclonal antibody, CD33 monoclonal antibody, CD38 monoclonal antibody Monoclonal antibodies, CD52 monoclonal antibodies, CDK4 / 6 inhibitors, central nervous system drugs , cephalosporins, cephalosporins / beta-lactamase inhibitors, cermenol drugs, CFTR combinations, CFTR potentiators, CGRP inhibitors, chelators, chemokines receptor antagonists, chloride channel activators, cholesterol absorption inhibitors, cholinergic agonists, cholinergic muscle stimulants, cholinesterase inhibitors, CNS stimulants, coagulation modifiers agents, colony-stimulating factors, contraceptives, adrenocorticotropic hormones, coumarins and indanediones, cox-2 inhibitors, decongestants, dermatological drugs, diagnostic radiopharmaceuticals, diarylquinolines, Dibenzazepine anticonvulsants, digestive enzymes, dipeptidyl peptidase 4 inhibitors, diuretics , dopaminergic antiparkinsonian drugs, drugs used in alcoholism, echinocandins Candida, EGFR inhibitor, estrogen receptor antagonist, estrogen, expectorant, factor Xa Factor inhibitors, fatty acid derivative anticonvulsants, fibric acid derivatives, first-generation cephalosporins 4th generation cephalosporins, functional bowel disorder agents, gallstone solubilizers, gamma-aminobutyric acid analogues , gamma-aminobutyric acid reuptake inhibitors, gastrointestinal agents, general anesthetics, genitourinary tract drugs, gastrointestinal stimulants, Glucocorticoids, glucose-elevating agents, glycopeptide antibiotics, glycoprotein platelet inhibitors , glycylcycline, gonadotropin-releasing hormone, gonadotropin-releasing hormone antagonist Drugs, gonadotropins, Group I antiarrhythmics, Group II antiarrhythmics, Group III Antiarrhythmics, Group IV antiarrhythmics, Group V antiarrhythmics, Growth hormone receptor blockade Drugs, growth hormone, guanylate cyclase-C agonist, Helicobacter pylori eradicant, H2 antagonist , hedgehog pathway inhibitor, hematopoietic stem cell mobilizing agent, heparin antagonist, heparin, HER2 inhibitor Antineoplastic agents, herbal products, histone deacetylase inhibitors, hormones, hormone / antineoplastic agents, Dantoin anticonvulsants, hydrazide derivatives, illegal (street) drugs, immunoglobulins, Immunological agents, immunostimulants, immunosuppressants, impotence agents, in vivo diagnostic biological agents, inks Retinomimetics, inhaled anti-infectives, inhaled corticosteroids, inotropics, insulin , insulin-like growth factor, integrase strand transfer inhibitor, interferon, interro Iodine inhibitors, interleukins, parenteral nutrition products, iodinated contrast media, ionic iodine Contrast media, iron products, ketolides, laxatives, antileprosy drugs, leukotriene modifiers, lincomycin derivatives Conductors, local injectable anesthetics, local injectable anesthetics with corticosteroids, loop diuretics Drugs, pulmonary surfactants, lymphatic stains, lysosomal enzymes, macrolide derivatives, macrolides , magnetic resonance imaging contrast agents, mast cell stabilizers, medical gases, meglitinides, metabolic agents, Methylxanthines, mineralocorticoids, minerals and electrolytes, other drugs, other sedatives Pain medications, other antibiotics, other anticonvulsants, other antidepressants, other antidiabetics drugs, other antiemetics, other antifungals, other antihyperlipidemics, other antihypertensives combinations, other antimalarials, other antitumor drugs, other antiparkinsonian drugs, other antipsychotics, other antituberculous drugs, other antiviral drugs, other anxiolytics, sedatives Sedatives and hypnotics, other bone resorption inhibitors, other cardiovascular drugs, other central nervous system drugs, Other coagulation modifiers, other diagnostic dyes, other diuretics, other genitourinary tract drugs, Other gastrointestinal drugs, other hormones, other metabolic agents, other ophthalmic drugs, other otic drugs Other Respiratory Drugs, Other Sex Hormones, Other Topical Drugs, Other Unclassified Drugs, other vaginal drugs, mitotic inhibitors, monoamine oxidase inhibitors, mouth and throat products , mTOR inhibitors, mucolytics, multikinase inhibitors, muscle relaxants, mydriatics, narcotic analgesics Combinations of medications, narcotic pain relievers, nasal anti-infectives, nasal antihistamines and decongestants, nasal Lubricants and cleansers, nasal preparations, nasal steroids, natural penicillins, neprilysin inhibitors , neuraminidase inhibitors, neuromuscular blockers, neural potassium channel openers, next-generation Phalosporins, nicotinic acid derivatives, NK1 receptor antagonists, NNRTIs, non-cardioselective venoms Data blockers, non-iodinated contrast media, non-ionic iodinated contrast media, non-sulfonylureas, non-steroidal anticoagulants Anti-inflammatory drugs, NS5A inhibitors, nucleoside reverse transcriptase inhibitors (NRTIs), and nutritional Food supplements, nutritional products, ophthalmic anesthetics, ophthalmic anti-infectives, ophthalmic anti-inflammatory drugs, ophthalmic antihistamines Ophthalmic ophthalmic lubricants and cleaners, ophthalmic diagnostic agents, ophthalmic glaucoma medications, ophthalmic lubricants and cleaners, ophthalmic preparations for eye drops, ophthalmic steroids, ophthalmic steroids including anti-infectives, ophthalmic surgical preparations, oral nutrition Nutritional supplements, other immunostimulants, other immunosuppressants, otic anesthetics, otic anti-infectives, otic preparations, Otic steroids, otic steroids including anti-infectives, oxazolidinedione anticonvulsants, Oxazolidinone antibiotics, parathyroid hormone and analogs, PARP inhibitors, PCSK9 inhibitors, penicillinase-resistant penicillins, penicillins, peripheral opioid receptor antagonists, peripheral Peripheral opioid receptor mixed agonist / antagonist, peripheral vasodilator, peripherally acting anti-obesity agent, Phenothiazine antiemetics, phenothiazine antipsychotics, phenylpiperazine antidepressants, phosphate Binders, PI3K inhibitors, plasma expanders, platelet aggregation inhibitors, platelet stimulators, poly Potassium-sparing diuretics, including enes and thiazides, potassium-sparing diuretics, and probiotics Progesterone receptor modulators, progestins, prolactin inhibitors, prostagrams Randin D2 antagonist, protease inhibitor, protease-activated receptor 1 antagonist, protease asome inhibitors, proton pump inhibitors, psoralens, psychotropic drugs, psychotropic drug combinations Purine nucleosides, pyrrolidine anticonvulsants, quinolones, radiocontrast agents, radiocomplements adjuvant, radiotherapeutic agent, radioconjugate, radiopharmaceutical, recombinant human erythropoietin, Nin inhibitors, respiratory agents, respiratory inhalation products, rifamycin derivatives, salicylic acid, sclerosing agents, 2 Generation cephalosporins, selective estrogen receptor modulators, selective immunosuppressants, selective hormonal inhibitors Phosphodiesterase-4 inhibitors, selective serotonin reuptake inhibitors, serotonin-nor Combination of epinephrine reuptake inhibitors, serotonergic neurointestinal modulators, and sex hormones combination of sex hormones, SGLT-2 inhibitors, and skeletal muscle relaxants; skeletal muscle relaxants; smoking cessation drugs, somatostatin and somatostatin analogues, spermicides, statins, sterile irrigation solutions, Leptogramins, Streptomyces derivatives, succinimide anticonvulsants, sulfonamides drugs, sulfonylureas, synthetic ovulation stimulants, tetracyclic antidepressants, tetracyclines, therapeutic radiation Sexual medicines, therapeutic vaccines, thiazide diuretics, thiazolidinediones, thioxanthenes, Third generation cephalosporins, thrombin inhibitors, thrombolytic agents, thyroid agents, TNF-alpha inhibitors Toxicants, tocolytic agents, topical acne agents, topical agents, topical allergy diagnostic agents, local anesthetics, Topical anti-infectives, topical anti-rosacea agents, topical antibiotics, topical anti-fungals, topical antihistamines, Topical antitumor agents, topical antipsoriatic agents, topical antiviral agents, topical astringents, topical debridements, topical debridements Pigments, topical emollients, topical keratolytic agents, topical nonsteroidal anti-inflammatory drugs, topical photosensitizers topical steroids, topical steroids including anti-infectives, topical rubefacients, topical steroids including anti-infectives, topical Transthyretin stabilizers, triazine anticonvulsants, tricyclic antidepressants, trifunctional monoclonal antibodies Clonal antibodies, ultrasound contrast agents, upper respiratory tract combination agents, urea anticonvulsants, urea cycle disorder agents, urinary Medium anti-infective, urinary antispasmodic, urinary pH adjuster, uterine contraction agent, vaccine combination, vaginal anti-infective Medicines, vaginal preparations, vasodilators, vasopressin antagonists, vasopressors, VEGF / VEGFR inhibitors antivirals, viral vaccines, mucosupplements, vitamin and mineral combinations, vitamins, or The drug administration device of the present disclosure may be used to administer epinephrine, Re, or a VMAT2 inhibitor. bif, Enbrel, Aranesp, atropine, pralidoxime chloride, diazepam , insulin, atropine sulfate, avibactam sodium, bendamustine hydrochloride, Carboplatin, daptomycin, epinephrine, levetiracetam, oxaliplatin, Paclitaxel, pantoprazole sodium, treprostinil, vasopressin, bovine serum albumin Conazole, zoledronic acid, mometasone, fluticasone, ciclesonide, budesonide, benzamidine Clometasone, vilanterol, salmeterol, formoterol, umeclidinium , glycopyrrolate, tiotropium, aclidinium, indacaterol, salmeterol - A drug selected from the group consisting of cyclosporine, cyclosporine, and olodaterol may be administered.

[0075] As noted above, any of a variety of drugs can be delivered using the drug administration device. Examples of drugs that can be delivered using the drug administration devices described herein include Remi Cade® (infliximab), Stelara® (ustekinumab) Mab), Simponi® (golimumab), Simponi Aria® (golimumab), Darzalex® (daratumumab), Tremfy® a® (guselkumab), Eprex® (epoetin alfa), R Isperdal Constra® (risperidone), Invega Su stenna® (paliperidone palmitate), and Invega Trin za® (paliperidone palmitate).

[0076] Drug Housing As noted above, the dosage form may be provided in a holder appropriate for the particular dosage form utilized. For example, a liquid dosage form of a drug may be placed in a vial with a stopper or a vial with a plunger prior to administration. The dosage form may be a solid or powdered dosage form, e.g., as a tablet, held in a holder in the form of a syringe. The drug is contained within a housing arranged to hold the tablet securely prior to administration. It is possible.

[0077] The housing may include one or more medication holders, each holder containing a dosage form. For example, the drug may be in the form of a tablet, and the housing may include a plurality of holders each having a tablet. It may be in the form of a blister pack held in a recess of the blister pack. Holder.

[0078] FIG. 6 shows a housing 63 with a plurality of medication holders 610, each containing a dosage form 611. The housing 630 is designed to be able to withstand various environmental conditions, such as temperature, time, or location. At least one environmental sensor configured to sense information about the existing environment 94. The housing 630 may accommodate the drug in the dosage form 611 contained within the holder 610. at least one device sensor 92 configured to sense information related to For example, determining the geographic location of the housing 630 via satellite positioning such as GPS. There may be a dedicated position sensor 98 configured to determine

[0079] The housing 630 stores information regarding the status of the drug in the dosage form 611 contained within the holder 610. The housing may include an indicator 85 configured to present information to a user of the housing. The housing 630 may also include a drug housing 630, an environment, a time, or a place, and and / or communicating information externally via wired or wireless transmission of data relating to the drug itself. The communication interface 99 may include a communication interface 99 capable of

[0080] Optionally, the housing 630 may include one or more electrical components of the housing 630. The device may include a power supply 95 for delivering power to the components. The power supply 95 is integral with the housing 630. The housing 630 may be a power source and / or a mechanism for connecting the housing 630 to an external power source. The housings 630 are also powered by a power supply 95 and are electrically isolated from each other and, optionally, the environment. sensors 94, position sensors 98, device sensors 92, communication interfaces 99, and / or or indicator 85. The device may include a computer system 90 including a processor 96 and memory 97. The processor 96 is connected to the environment sensor 94, the device sensor 92, and the communication interface 99. , acquiring data obtained from the position sensor 98 and / or the user interface 80 and process it, for example, to provide an indicator 85 and / or a communication interface 9 9.

[0081] The housing 630 may be in the form of packaging. Alternatively, additional packaging may be used. A ring may be present to contain and surround the housing 630 .

[0082] The holder 610 or additional packaging may itself be a device cell, as described above. sensor 92, environmental sensor 94, indicator 85, communication interface 99, power supply 95, A position sensor 98 and a device computer system including a processor 96 and memory 85 The system may include one or more of the following:

[0083] Electronic Communications As mentioned above, the communication interface 99 may be located in or on the housing 30, 630. , or alternatively contained within or on packaging 35 to facilitate drug administration. Such a communication interface may be associated with the device 500 or the medication housing 630. The interface 99 may be connected to a remote computer system such as the central computer system 700 shown in FIG. As shown in FIG. 7, the drug administration device may be configured to communicate with a computer system. The communication interface 99 associated with the housing 630 or the communication network Through network 702, a medical facility 706, such as a hospital or other medical center, a home base 708 (e.g., a patient's home or office, or a caretaker's home or office) 710, access to the central computer system from any number of locations, such as a central office, or mobile location 710. The communication interface 99 is configured to communicate with the network 700. 702. In one exemplary embodiment, the communication interface 99 of FIG. 0 is configured to be accessed wirelessly, for example, via a Wi-Fi connection, This may facilitate the accessibility of the system 700 from almost anywhere in the world.

[0084] Those skilled in the art will appreciate that system 700 may be configured to utilize the features of system 700 available to any particular user. may be based, for example, on the identity of the user and / or the location from which the user is accessing the system. It will be understood that the security features may be included as may be determined based on the To facilitate access to the system 700, each user must have a unique It may include a username, password, and / or other security credentials. The security parameter information determines whether the user is authorized and to what extent the user is authorized. , are allowed to interact with the system, view information stored in the system, etc. The user may be checked against a database of authorized users to determine if the user is a

[0085] Computer Systems As discussed herein, one or more aspects or aspects of the subject matter described herein may be The components of the central computer system 700, such as the processor 96, the power supply 9 5, memory 97, communication interface 99, user interface 80, device interface The indicators 85, device sensors 92, environmental sensors 94, and position sensors 98 are digital electronic circuits, integrated circuits, specially designed application specific integrated circuits (ASICs) Integrated Circuit (ASIC), Field Programmable Gate Array (Field Pro FPGA (Programmable Gate Array) computer hardware, firmware, and software Various aspects or features of these may be implemented in a variety of ways, including, but not limited to, software, hardware, and / or combinations thereof. , executed on a programmable system including at least one programmable processor. involves the execution of one or more computer programs that are executable and / or interpretable The processor may include a storage system, at least one input device, and at least one connected to receive data and instructions from and send data and instructions to two output devices It can be a dedicated or general-purpose processor connected to a programmable system or The computer system may include clients and servers. The servers are generally remote from each other and are typically connected via a communications network, e.g., the Internet. network, wireless wide area network, local area network, wide area network, or The client and server relationships are computer programs that run on computers and have a client-server relationship with each other Produced by grams.

[0086] A computer program is a program, software, or software application. It may also be called a program, application, component, or code. It includes machine instructions for programmable processors, high-level procedural languages, object-oriented programming languages, functional programming languages, logic programming languages, and / or may be implemented in assembly / machine language. As used herein, the term "machine-readable medium" refers to a "Device" includes, for example, magnetic disks, optical disks, memories, and programmable logic devices. Any computer-programmable device, such as a Programmable Logic Device (PLD) refers to any product, device, and / or apparatus that is capable of receiving machine instructions as machine-readable signals. Includes a machine-readable medium for providing machine instructions and / or data to a programmable processor The term "machine-readable signal" is used to describe a signal that can be used to transmit machine instructions to a programmable processor. A machine-readable medium refers to any signal used to provide data, e.g. For example, non-transient solid-state memory or a magnetic hard drive, or any equivalent storage medium. Such machine instructions may be stored non-transitoryly on a machine-readable medium, such as a processor. processor cache, or associated with one or more physical processor cores storing such machine instructions in a temporary manner, such as in a memory or other random access memory; It can be additionally stored.

[0087] To provide for interaction with a user, one or more aspects of the subject matter described herein may be used. The user interface 80 (including the dispensing device 500 or housing 630 or separate) may be used, for example, to display information to the user. Cathode Ray Tube (CRT) or Liquid Crystal Display (LCD) LCD (Light Emitting Diode, LED) monitors and other displays The display screen may be implemented on a computer that can be directly (e.g., touch) screen) or indirectly (e.g., through a keypad or voice recognition hardware and software) Other types of input devices may be used to input data to the display screen. The device can be used to provide for user interaction as well. For example, The feedback provided may be, for example, visual feedback, auditory feedback, or Input from the user, which can be any form of sensory feedback, such as haptic feedback may receive input in any form, including but not limited to acoustic, voice, or tactile input. As mentioned above, this feedback may be displayed on the user interface 80. Additionally, the device may be provided via one or more device indicators 85. The indicator 85 may be used to provide this feedback or to receive input from the user. To receive the signal, the device sensors 92, the environmental sensors 94, and / or the position sensors 98 are used. may interact with one or more of:

[0088] FIG. 8 is an example of computer system 700 shown as computer system 800. 8 shows an exemplary embodiment of a computer system 800. The processor 896 includes one or more processors 896 configured to control the The processor 896 may be a programmable general-purpose or special-purpose microprocessor and / or a variety of Includes either a dedicated or commercially available single or multi-processor system any type of microprocessor or central processing unit The computer system 800 may also include a processor 896. for the code to be executed, or for one or more users, storage devices, and / or or configured to provide temporary storage for data obtained from a database. The memory 897 may include one or more read-only memories. ROM, flash memory, one or more of various random access memories ( random access memory (RAM) (e.g., static RAM (SRAM), dynamic RAM) Dynamic Random Access Memory (DRAM), or Synchronous Dynamic Random Access Memory (SDRAM), and / or memory A combination of memory technologies may be included.

[0089] The various elements of the computer system are coupled to a bus system 812. The bus system 812 is connected by appropriate bridges, adapters, and / or controllers. Any one or more separate physical buses, communication lines / interfaces connected by abstractions representing the source, and / or multi-drop or point-to-point connections The computer system 800 also includes one or more network interfaces. interface 899 (also referred to herein as a communication interface), one or two or more input / output (IO) interfaces 880 and one or more storage devices 8 Includes 10.

[0090] The communications interface 899 allows the computer system to communicate with remote devices, e.g. , and network with other computer systems and / or devices 500 or housing 630. may be configured to allow communication over a network, or may be configured to allow communication over a remote Desktop connection interface, Ethernet adapter, and / or other local It can be a Local Area Network (LAN) adapter. Interface 880 is one or more devices for connecting computer system 800 to other electronic devices. includes two or more interface components. For example, IO interface 880 includes , Universal Serial Bus (USB) port, 1394 port, Wi-Fi, Blue Additionally, the computer system may include a high speed data port such as a The IO interface 880 may be accessible to users throughout the Playback, speakers, keyboard, pointing device, and / or various other video , audio, or alphanumeric interfaces. This includes any conventional medium for storing data in a transient and / or non-transitory manner. Thus, the storage device 810 retains its value despite an interruption of power to the computer system. The storage device is configured to hold data and / or instructions in a persistent state that is maintained. The 810 can store one or more hard disk drives, flash drives, USB drives, drives, optical drives, various media cards, diskettes, compact discs, and and / or any combination thereof, whether directly connected to a computer system. or may be remotely connected to a computer system, such as via a network. In one embodiment, the storage device 810 may be, for example, a hard disk drive, a flash drive, Hard drives, USB drives, optical drives, media cards, diskettes, or A tangible or non-transitory compact disk configured to store data, such as a compact disc. computer-readable media.

[0091] The elements illustrated in FIG. 8 may be some or all of the elements of a single physical machine. In addition, not all of the illustrated elements need be located on or within the same physical machine. do not have.

[0092] The computer system 800 may process a web page or other markup language stream. to search, and to browse (visually, audibly, or otherwise) those pages and / or streams; presenting the page / stream in a way that allows scripts, controls, and other commands to be executed on those pages / streams to execute commands (e.g., to complete input fields) on those pages / Accepting user input for a stream, H for those pages / streams Issues a HyperText Transfer Protocol (HTTP) request or by other means (e.g., by submitting information from completed input fields to a server). This may include a web browser for displaying web pages or other markup languages. The term stands for HyperText Markup Language (H TML), or Embedded Extensible Markup Language (EML) and other traditional forms including Markup Language (XML), scripts, controls, etc. The computer system 800 may also generate web pages and / or It may include a web server for distribution to an external computer system.

[0093] As shown in FIG. 7, the computer system 800 of FIG. 8 may include one or more The device computer of the two or more individual drug administration devices 500 or housings 630 a central computer system 700 in communication with one or more of the data systems 90; Operational data of the device 500 or the housing 630, such Data, such as patient medical data, acquired by the device 500 or housing 630 can be exchanged between the central and device computer systems 700, 90.

[0094] As previously mentioned, the above-described computer system 800 may also be used in conjunction with the drug administration device 500 or The device computer system may be integrated into the housing 630 or may be located in close proximity to the housing. In this regard, one or more processors may form a component of system 90. 896 corresponds to the processor 96, and the network interface 799 is a communication interface. The IO interface 880 corresponds to the user interface 8 0, and memory 897 corresponds to memory 97. Furthermore, additional storage device 810 also It may also reside within the device computer system 90.

[0095] In one exemplary embodiment, the computer system 800 may, for example, A single unit of one or more medication delivery devices 500 housed within a device housing 30. A single package 35 or a plurality of medication holders 610 are contained within a housing 630. The devices may be integrated into a single computer system 90. The computer system 800 may be implemented as a single unit, as a single server, or as a single The central computer system 700 may be configured as a tower.

[0096] A single unit may be configured such that its various aspects do not disrupt the functioning of any other aspect of the system. can be swapped out as needed, for example for upgrades, replacements, or maintenance, without It can be modular so that it can be plugged in and out. It can also be extensible with capabilities being added as additional modules, and / or additional functionality of existing modules is desired and / or improved.

[0097] A computer system also includes, by way of example, an operating system and a database. various other software and / or hardware components, including the data management system An exemplary computer system is shown and described herein. Although the figures are shown here, it will be understood that this is for generality and convenience. In some embodiments, the computer system may be different in architecture from that shown and described herein. For example, memory 897 and storage 810 together may If it can be integrated or communication with another computer system is not required, Interface 899 may be omitted.

[0098] A. Implementation The embodiments of the drug delivery devices described herein may be used to prevent the drug delivery device from becoming wet or contaminated. The device may be configured for use in an environment where it may be exposed to contaminating substances, thereby preventing misapplication of the drug. This may reduce the risk of patient harm resulting from use.

[0099] The embodiments of the drug delivery devices described herein allow the user to The drug administration device may be configured to prevent drug from being left unadministered, thereby This may improve patient compliance and therefore safety.

[0100] In an exemplary embodiment, a drug administration device configured to administer a drug includes a first a housing including a housing electrical contact and a second housing electrical contact; a medication holder configured to hold a medication; and a medication administration device. a removable power supply configured to power the device, the removable power supply including a first power electrical contact and a second power electrical contact; and a power supply that can be operated. The housing includes a housing protection mechanism, and / or the power supply includes: The housing protection mechanism may include a power supply protection mechanism. a first configuration that protects the first housing electrical contact when the first housing electrical contact is not engaged; When the rechargeable power source is received within the housing, the first and second housing electrical contacts and a second configuration allowing contact between the first and second power supply electrical contacts, respectively. The power supply protection mechanism is configured to When the second power supply is in a first configuration, the electrical contacts are protected and the removable power supply is in a housing. When received within the housing, the first and second housing electrical contacts and the first and second power supply voltages and a second configuration that allows contact between the air contacts and the air contacts, respectively.

[0101] Protecting the electrical contacts of the housing and / or removable power source allows for The device can be used and the power supply can be recharged if either the housing or the removable power supply is contaminated. It can be replaced in environments where there is a risk of contact with the substance. In the future, wearable drug administration devices will be developed, which will inevitably be carried and used anywhere. This may be particularly suitable for power supply devices, which consume a large amount of power and are therefore difficult to handle. Suitable for drug delivery devices that require periodic removal and / or replacement of a removable power supply It could be.

[0102] The form of the drug delivery device can be any of the drug delivery devices described herein .

[0103] The housing of the drug delivery device is the outer part of the drug delivery device. The housing of the chair is configured to keep contaminants out of the interior portions of the medication delivery device. and the internal portion of the medication delivery device includes all of the medication delivery device disposed within the housing. In particular, the housing is water-resistant in accordance with IEC standard 60529, e.g. IPX2, IPX3, IPX4, IPX5, IPX6, IPX7, IPX8 or higher The housing may be configured to have a waterproof property to the extent that the outer portion of the medication administration device is waterproof. and if the housing is constructed to be water-resistant or waterproof, A removable power source is received within the housing to provide adequate water resistance or waterproofing. When the power supply is connected to the power source, it may be coupled to a portion of the removable power source.

[0104] The drug holder of the drug administration device can be of any suitable form for holding a drug. As described herein, such suitable forms include a vial or a syringe.

[0105] The removable power source of the medication delivery device is a primary power source configured for single use only. Alternatively, the removable power source may be a secondary battery configured to be recharged. Primary batteries may include, for example, zinc-carbon batteries or alkaline batteries. The secondary battery may be, for example, a nickel-cadmium cell, a nickel-zinc cell, or a nickel Mention may be made of hydrogen cells or lithium ion cells.

[0106] First and second housing electrical contacts and first and second power supply electrical contacts of the drug administration device The contacts are between the first housing electrical contact and the first power supply electrical contact, and between the second housing electrical contact and the An electrical contact is configured such that electrical contact can be made between the electrical contact and a second power supply electrical contact. When the removable power source is received in the housing, the first housing electrical contact and The first power supply electrical contact and the second housing electrical contact and the second power supply electrical contact are The housing and the removable power source are in contact with each other so that an electrical circuit between them is completed. may provide power to other components of the drug administration device from a removable power source. do.

[0107] The protection mechanism(s) may be configured to: The first configuration is configured such that the protection mechanism is in contact with each electrical contact. The first configuration provides a protective function against liquid on each electrical contact. Alternatively or additionally, the first configuration may be configured to reduce or prevent body invasion. may be configured to reduce or prevent the ingress of solid particles into the respective electrical contacts The reduction in the ingress of liquids and / or solid particles into the respective electrical contacts occurs in the absence of a protective mechanism. In this way, the protection mechanism(s) protect the electrical contacts Helps protect against contamination.

[0108] The protection mechanism(s) may be configured to: The second configuration is configured as in the second configuration. This allows the connection of a removable power supply received within the housing. Thus, the action of mating the removable power supply with the housing activates the protection mechanism first. This can be achieved by moving the connection from one configuration to the second configuration. The device may be configured to be manually movable between a first configuration and a second configuration to enable do.

[0109] The housing protection mechanism prevents the removable power supply from being removed when inserted into the housing. configured to move between a first configuration and a second configuration by contacting a power source The housing protection mechanism is configured to change from the first configuration to the second configuration. As it moves, it moves along the surface of the first housing electrical contact and possibly the second housing. The housing is configured to move along the surface of the electrical contact(s). By moving along the surface(s), the housing protection mechanism contacts the electrical contact(s). Physically scrape or remove any contaminants that may have collected on the surface(s) of the Wiping, thereby forming electrical contacts when the removable power source is received within the housing. and provides a cleaner surface between the first housing electrical contact and the first power electrical contact. , and the housing protection mechanism also moves along the surface of the second housing electrical contact. In this case, an efficient electrical connection is established between the second housing electrical contact and the second power electrical contact. You can be sure it exists.

[0110] The housing protection mechanism is configured to form a seal around the first housing electrical contact. As used herein, a seal is defined as a seal that prevents contaminants from passing between two surfaces at the interface. The contact area is an area that is vulnerable to the ingress of contaminants. The contaminant may be a liquid and / or a solid. The seal is a seal between two surfaces. The seal is designed to prevent moisture from passing through at the contact points. A seal may be formed between the housing and the electrical contacts. By this, the housing protection mechanism prevents the removable power supply from being received within the housing. When the battery is not in use, moisture comes into contact with the first housing electrical contact and the second housing electrical contact, Potentially creating a circuit between the first housing electrical contact and the second housing electrical contact and in environments where there is a risk of the drug administration device coming into contact with contaminants, e.g., moisture. This may reduce the risk of malfunction of the drug administration device when used in

[0111] Additionally, the housing protection mechanism may be configured to seal the first housing electrical contact. For example, sealing the first electrical contact to prevent the ingress of contaminants from a range of directions. In this regard, the housing may be configured to protect the first housing electrical contact from the intrusion of contaminants in a particular direction. The sealing of the first electrical contact can be done at this interface, for example. forming a seal around the first housing electrical contact to prevent ingress of contaminants; By doing so, the first housing electrical contact is protected from the intrusion of contaminants in the remaining direction. .

[0112] The seal may be formed by covering the first housing electrical contact with a sealing layer. The sealing layer may include an elastomeric material. The use of an elastomeric material may It may be possible to support being movable from a first configuration to a second configuration.

[0113] The housing protection mechanism may be in the form of a membrane. The first housing electrical contact may include a membrane in the form of a layer extending over the first housing electrical contact. The first housing electrical contact may be sealed to protect the contact from ingress of contaminants.

[0114] As used herein, membrane refers to a sheet or film of flexible material. The membrane may be substantially impermeable to contaminants of concern, e.g., The membrane may be impermeable to water. The membrane of the drug delivery device may be a synthetic membrane. The membrane of the drug delivery device may comprise an elastomeric material. The membrane of the drug delivery device may comprise a polymer, e.g. For example, cellulose acetate, nitrocellulose, cellulose ester, polysulfone, polyethylene teresulfone, polyacrylonitrile, polyamide, polyimide, polyethylene, poly Propylene, polytetrafluoroethylene, polyvinylidene fluoride, polyvinyl chloride, etc. may include:

[0115] The first power electrical contact may be configured to penetrate the housing protection mechanism. In this embodiment, the housing protection mechanism is configured to be penetrable. The first power supply electrical contact is configured to pass through the housing protection mechanism in the form of a membrane. This is particularly relevant when the action of penetrating the housing protection mechanism The ring protection mechanism is forced into the second configuration, which can result in contact between the electrical contacts. When multiple housing electrical contacts are protected by a penetrable housing protection mechanism Each of the plurality of power electrical contacts is configured to penetrate an associated housing protection mechanism. The use of a penetrating action can also move along the surface of the electrical contact and This has the benefit of a housing protection mechanism that removes contaminants before connection.

[0116] Each power electrical contact includes at least one sharp or pointed feature. The housing protection mechanism may be configured to penetrate the housing electrical contacts. A power supply electrical connector protected by a housing protection mechanism and configured to penetrate the housing protection mechanism. By having the points, the medication delivery device can be There may be contaminants present that could prevent electrical connection between the housing electrical contacts and the power supply electrical contacts. may be configured to reduce

[0117] As mentioned above, the housing protection mechanism has only one electrical contact, e.g., the first housing. In this case, the protective circuit may be configured to protect the other electrical contacts. There may be additional housing protection features. If additional electrical contacts are present, these may also , can be protected by additional housing protection mechanisms. In this way, each of the contacts If a contaminant ingress problem is associated with one of these contacts, they can be protected separately. If the contacts are separated, the problem will not affect other contacts. Ensures that contaminants do not cause unwanted short circuits between contacts. If multiple housing protection mechanisms are present, each of the housing protection mechanisms shall be of the same form. Alternatively, the housing protection mechanism may be of a different form. The features described in relation to the housing protection mechanism that protects the electrical contacts of the housing may be added to the additional housing. This rule applies equally to each of the protection mechanisms.

[0118] Instead of a single housing protection mechanism configured to protect a single electrical contact A single housing protection mechanism may be configured to protect multiple contacts and prevent the ingress of contaminants. This can effectively provide protection from intrusion.

[0119] The first housing electrical contact may be coated with a hydrophobic coating. In this context, "hydrophobicity" refers to the ability of a coating to resist a given surface, as measured by the static drop method. This means that the contact angle of a water droplet exceeds 90°, 100°, 110°, or 120°. The hydrophobic coating has virtually no effect on the conductivity of the entire coating layer. This can be achieved by using a conductive hydrophobic coating. As used herein, "electrically conductive" means that the coating has an electrical resistivity of 10 -4 Ωm, 1 0 -5 Ωm, 10 -6 Ωm, 10 -7 Ωm, or 10 -8 This means that the resistance is less than Ωm. Examples of hydrophobic conductive coatings include carbon nanotube structures, silica nanocoatings, and the like. Examples of suitable conductive coatings include polycrystalline gold, polycrystalline silver, and polycrystalline copper. The etch can be achieved by etching the surface of the electrical contact. The first housing electrical contact is coated with a hydrophobic coating. The amount of moisture contamination that collects on the surface of the housing is reduced. and a first housing configured to move along a surface of the electrical contact when moving between the first housing and the electrical contact. In combination with coating the first housing electrical contact with a hydrophobic coating. By doing so, when the removable power supply is inserted into the housing, the first The surfaces of the housing electrical contacts are cleaned more effectively.

[0120] The features described in relation to the housing protection mechanism are as follows: the power supply protection mechanism is a housing protection mechanism; It applies equally to power protection mechanisms, if present in addition to or instead of: The first housing electrical contact may be protected by a housing protection mechanism, and the second power supply electrical contact may be protected by a housing protection mechanism. The contacts may be protected by power protection mechanisms. In addition, both of these protection mechanisms Therefore, the second housing electrical contact and the first power supply electrical contact can be , through the power supply protection mechanism and the housing protection mechanism, respectively, and It may be configured to form an electrical contact that may provide a form of protection to the source electrical contact.

[0121] The power supply protection mechanism prevents the removable power supply from contacting the housing when inserted into the housing. The device is configured to move between the first configuration and the second configuration upon contact with the device. The power protection mechanism may be configured to: moving along the surface of the power source electrical contact and possibly along the surface of the second power source electrical contact. By moving along the surface(s) of the electrical contact(s), The power protection mechanism may be concentrated on the surface(s) of the electrical contact(s). Any contaminants can be physically scraped or wiped off, thereby making them removable. Provides a cleaner surface for electrical contacts when the power source is received in the housing, A power protection mechanism is also provided between the power supply electrical contact and the first housing electrical contact. When moving along the surface of the power contact, the second power contact and the second housing contact It can be ensured that there is an efficient electrical connection between the contacts.

[0122] The power supply protection mechanism may be configured to form a seal around the first power supply electrical contact. A seal may be formed between the power supply protection mechanism and the removable power supply itself. a seal configured to form a seal around the first power electrical contact and the second power electrical contact; By forming a seal around the power supply electrical contacts, the power supply protection mechanism is removable. When the power source is not received in the housing, moisture may penetrate the first power source electrical contact and the second power source electrical contact. contacting the power supply electrical contacts and potentially establishing a circuit between the first power supply electrical contact and the second power supply electrical contact; and the risk of the drug administration device coming into contact with contaminants, e.g., moisture. This may reduce the risk of malfunction of the drug administration device when used in certain environments.

[0123] Furthermore, the power supply protection mechanism may be configured to seal the first power supply electrical contact, e.g., The electrical contacts of the device are sealed to prevent the intrusion of contaminants from a certain range of directions. Therefore, the removable power supply protects the first power supply electrical contact from the ingress of contaminants in a specific direction. The sealing of the first electrical contact can be, for example, to prevent the release of contaminants at this interface. forming a seal around the first power electrical contact to prevent intrusion; Protects the power supply electrical contacts of 1 from the ingress of contaminants in the remaining direction.

[0124] The seal may be formed by covering the first power electrical contact with a seal layer. The power protection mechanism may include an elastomeric material. The use of an elastomeric material may be advantageous in that the power protection mechanism may be This may assist in being able to move from one configuration to the second.

[0125] The power protection mechanism may be in the form of a membrane. The power protection mechanism extends over the first power electrical contact. The first power supply electrical contact may include a membrane in the form of a layer that protects the first power supply electrical contact from the ingress of contaminants. The first power electrical contact may be sealed to provide protection.

[0126] The first housing electrical contact may be configured to penetrate the power protection mechanism. In this embodiment, the power supply protection mechanism is configured to be penetrable. The first housing electrical contact is particularly suitable when the power supply protection mechanism is in the form of a membrane. Actions that penetrate the power protection mechanism force the power protection mechanism to 2 configuration, which can result in contact between the electrical contacts. A plurality of respective housing electrical contacts when protected by a possible power protection mechanism may be configured to penetrate the associated power protection mechanism. It also travels along the surface of the electrical contact, removing any contaminants before making the connection. It has the benefit of power protection mechanisms.

[0127] Each housing electrical contact may include at least one sharp or pointed feature. The power supply protection mechanism can be configured to penetrate the power supply electrical contacts. and a housing electrical contact configured to penetrate the power supply protection mechanism. and the medication delivery device is connected to each of the power supply electrical contacts and the housing. The electrical contacts are configured to reduce the possibility of contaminants being present which may prevent electrical connection between the electrical contacts. It can be done.

[0128] As mentioned above, the power supply protection mechanism has only one electrical contact, for example, the first power supply electrical contact. In this case, additional power protection is required to protect other electrical contacts. If additional electrical contacts are present, these may also provide additional power protection. In this way, each of the contacts can be protected separately. If a contaminant ingress problem is associated with one of these contact points, the problem The contacts do not affect the other contacts. Furthermore, the separation of each contact is prevented by the ingress of contaminants. Ensures that no undesired short circuits occur between contacts. If so, each of the power protection mechanisms may be of the same type. Alternatively, the power protection mechanisms may be of different types. The power supply protection mechanism for protecting the first power supply electrical contact may be described as follows. The features described apply equally to each of the additional power protection mechanisms.

[0129] Instead of a single power protection mechanism configured to protect a single electrical contact, a single The power supply protection mechanism may be configured to protect a plurality of contacts and to protect against the ingress of contaminants. can be efficiently provided.

[0130] The first power electrical contact may be coated with a hydrophobic conductive coating. The first power source electrical contact is coated with a hydrophobic conductive coating. The amount of moisture contamination that collects on the contact surfaces is reduced. The power supply protection mechanism is divided into the first and second configurations. and configured to move along the surface of the first power electrical contact when moving between In combination with coating the first power electrical contact with a hydrophobic conductive coating, When the removable power supply is inserted into the housing, the first power supply electrical contact The surface is cleaned more effectively.

[0131] In a first configuration, the housing protection mechanism is configured to surround a first housing electrical contact. The power supply protection mechanism may be configured to form a seal between the first and second power supplies, in the first configuration. The first housing may be configured to form a seal around the electrical contact. By forming a seal around the second power electrical contact, the protection mechanism is removable. When the power source is not received in the housing, moisture may penetrate the first housing electrical contact and and a second power supply electrical contact is in contact with the first power supply electrical contact and the second power supply electrical contact, or the first Potentially creating a circuit between the housing electrical contact and the second housing electrical contact. and can be used in environments where there is a risk of the drug administration device coming into contact with contaminants, e.g., moisture. When this occurs, the risk of malfunction of the drug administration device may be reduced.

[0132] The power supply protection mechanism and the housing protection mechanism may each be a membrane, and the second housing electrical the contact and the first power supply electrical contact each have a contact when the power supply is received within the housing. Each membrane may be configured to penetrate the corresponding membrane so that the membrane is in the second configuration. the housing electrical contact and the first power electrical contact have at least one sharp or pointed feature. The first housing electrical contact may be configured to penetrate the corresponding membrane by including the first housing electrical contact. By protecting the first and second power supply electrical contacts with a membrane, the drug administration device Contaminants on the surface that can cause poor electrical connections between the power supply electrical contacts and the housing electrical contacts and can ensure that there is no electrical contact between the first power supply electrical contact and the second power supply electrical contact or Contaminants form a circuit between one housing electrical contact and a second housing electrical contact. You can be sure there is no way.

[0133] The second housing electrical contacts may be coated with a hydrophobic conductive coating. By coating the electrical contacts of the second housing with a hydrophobic conductive coating, The amount of moisture contamination that collects on the surface of the electrical contacts in the housing is reduced. , along the surface of the second housing electrical contact when moving between the first configuration and the second configuration. and configuring the second housing electrical contact to move along the hydrophobic conductive layer. By coating it with a conductive coating, a removable power supply can be inserted inside the housing. When the second housing is inserted, the surface of the electrical contacts is more effectively cleaned.

[0134] The second power supply electrical contact may be coated with a hydrophobic conductive coating. The second power source electrical contacts are coated with a hydrophobic conductive coating. The amount of water contamination that collects on the contact surface is reduced. The power supply protection mechanism is divided into the first and second configurations. and configured to move along the surface of the second power supply electrical contact when moving between In combination with the above, coating the second power supply electrical contact with a hydrophobic conductive coating and when the removable power supply is inserted into the housing, the second power supply electrical contact The surface is cleaned more effectively.

[0135] In another exemplary embodiment, the drug administration device configured to administer the drug comprises a housing; and a dispensing mechanism disposed within the housing, the dispensing mechanism configured to dispense the medication. a medication holder configured to hold a medication, the medication holder being positioned within the housing; at least one sensor configured to detect an environmental parameter; Receives data from at least one sensor and responds to data received from at least one sensor and a processor configured to modify operation of the medication administration device in response to the

[0136] The drug delivery device can be in the form of any of the drug delivery devices described herein.

[0137] The at least one sensor configured to detect the environmental parameter may, for example, , a hygrometer, a temperature sensor, a position sensor, a time sensor, etc. For example, a thermistor, thermocouple, resistance thermometer, or silicon bandgap temperature sensor. The location sensor determines the geographic location of the medication administration device by satellite positioning such as GPS. The time sensor may be, for example, an electric clock.

[0138] The drug delivery device is configured to be compatible with its internal environment, the safety or safety of the user of the drug delivery device as a result of the internal environment of the drug delivery device. It may be possible to avoid actions that may compromise the safety of the drug administration device. do.

[0139] The at least one sensor may be configured to directly or indirectly detect the contaminant. Such a sensor can be called a contamination sensor. The contamination is the substance whose presence is to be avoided. As described herein, contaminants may be liquids or solids (especially solids). The sensor may be a moisture sensor, a pressure sensor, an optical sensor, a current sensor, The moisture sensor may be, for example, a hygrometer or water sensor. The pressure sensor may be, for example, a piezoresistive strain gauge pressure sensor, a capacitance Pressure sensors, piezoelectric pressure sensors, strain gauge pressure sensors, optical pressure sensors, potentiometric pressure sensors pressure sensor, force balance pressure sensor, resonant pressure sensor, thermal pressure sensor, or ionization pressure sensor. The increase in pressure determined by the pressure sensor may indicate the presence of contaminants within the drug delivery device. It can indicate existence.

[0140] At least one sensor is used in conjunction with a processor to determine whether a contaminant is present. The processor compares the data generated by the sensor with a threshold band to determine whether If the data generated by the sensor is outside the threshold band, If so, the processor may conclude that a contaminant may be present in the medication administration device. The threshold band is the data output of the sensor when no contaminants are present in the drug delivery device. The number of the saturation points may be preselected based on the number of saturation points.

[0141] The at least one contamination sensor is adapted to detect light from a medication holder of the medication administration device. The processor may include a light sensor configured to: The medication holder may be configured to determine whether it contains contaminants. By providing information about the light to the processor, the processor can determine whether contamination is present in the medication holder. The device may be configured to identify the form of matter, such as solid particles, gas bubbles, Contaminants may be physical contaminants in the form of droplets or liquid droplets. It may be a chemical contaminant that changes the opacity. The contaminant may be the result of the drug changing over time. The processor may compare the data received from the light sensor with a standard value. Based on the data from the optical sensor, the device determines whether the medication holder contains a contaminant. The standard value for a particular drug and drug holder present in the drug administration device may be: The drug administration device may store the measured value in a memory. The processor may compare the measured value with a standard value or either due to deviation over time or when the medication holder and / or medication is replaced or installed. possible contamination by measuring the deviation of the light detected by the light sensor when A significant deviation from the standard value may indicate the presence of a contaminant in the medication holder. As used herein, significant deviation means that a particular medication holder and its As needed for the drug, 50%, 40%, 30%, 20%, 1 The change in intensity of a given wavelength can be 0%, 5%, 4%, 3%, 2%, 1%, or less. By being able to identify contamination within the medication holder, the medication administration device Preventing a user of the medication administration device from administering medication when the holder contains contaminants; This may reduce the risk of harm caused by contamination within the medication holder. Being able to identify contamination in the object holder allows for the drug administration device, e.g. The processor may notify the user of the medication administration device or a medical professional to insert the medication holder into the new medication. Modifications such as replacing the holder or replacing the drug administration device with a new drug administration device It may be configured to initiate an alert to trigger the execution of an action.

[0142] The medication holder is irradiated with at least one wavelength of light that the optical sensor is configured to detect. For example, the medication holder may be transparent at wavelengths of interest by less than 10%, less than 5%, or less than 2%. The optical sensor may attenuate light by 1% or less. The optical sensor may be configured to detect a wavelength of light. By configuring the medication holder to be transparent, the optical sensor can be placed on the outside of the medication holder. and reducing the complexity and / or cost of the medication holder. Since many medications are liquids, locating the optical sensor on the outside of the medication holder is unsafe. This means that a water-based optical sensor can be used.

[0143] The medication administration device may include a light source configured to illuminate the medication holder, and a light sensor The device may be configured to detect light from the light source after the light passes through the medication holder. In the specification, light is said to have passed through the drug holder when the light passes through any part of the drug holder. This is considered to be the result of light entering the medication holder and then being reflected by the body within the medication holder. This allows light to exit the drug holder in a direction substantially opposite to the direction it entered. The light source is adapted to emit light at a wavelength that the light sensor is configured to detect. The optical sensor is configured such that the light source is positioned on the other side of the medication holder and the medication holder facing the medication holder and oriented toward the optical sensor through at least a portion of the holder; In such an embodiment, the processor may be positioned on one side of the medication holder. The sensor may be configured to determine the contaminant by a deviation in the light detected by the sensor. The light sensor is positioned adjacent to the light source with both the light sensor and the light source oriented in the same direction. It can be done.

[0144] The wavelengths detected by and emitted by the optical sensor indicate the presence of the contaminant of interest. The wavelengths are chosen to correspond to the wavelengths affected by

[0145] The processor may enter limp mode when contamination is determined to be present by the processor. Initiating a drive operation in response to data received from the at least one sensor, The drug delivery device may be configured to modify its operation. The operation is such that the drug delivery device is unable to deliver the drug or delivers a reduced drug dose. This refers to the administration of a drug with reduced functionality, such as being unable to be administered. Due to this feature, drug delivery devices are designed to protect against the presence of contaminants that could compromise patient safety. It may be possible to avoid actions, thereby improving patient safety.

[0146] The exact form of limp mode is determined by a processor that compares the degree or form of contamination with a predetermined response. The predefined response may be stored in the memory of the drug administration device. do.

[0147] The processor indicates the status of the medication administration device to a user of the medication administration device. and modifying the operation of the medication administration device in response to data received from the at least one sensor. The processor may be configured to correct the device indicator or configured to indicate to a user via a user interface the status of the medication administration device. Additionally or alternatively, the processor may be configured to receive a notification from a user of, for example, a smartphone. to a wireless device owned by or otherwise associated with the by initiating wireless communication via the communication interface. The wireless communication may be configured to indicate the status of the medication administration device to the user. the dispensing device alerts a user of the drug administration device to the presence of a contaminant; Thus, enabling the user of the medication administration device to take the necessary action. The necessary action is to remove the contaminant or to seek medical professional help. It is possible.

[0148] The processor prevents actuation of the medication administration device when a contaminant is determined to be present. and providing a drug administration data set in response to data received from the at least one sensor. In other words, all of the medication delivery devices may be configured to modify the operation of the device. Contaminants can cause unintended effects on the drug delivery device. Therefore, prevention of drug delivery device operation provides improved user safety.

[0149] The processor may communicate with a remote server when a contaminant is determined to be present. and by controlling the medication administration device in response to data received from the at least one sensor. The processor may be configured to modify the operation of the communication interface of the medication administration device. The remote server may be configured to communicate with the drug delivery system via a drug delivery interface. and configured to initiate an order for a replacement medication holder in response to a communication from the medication administration device. and thereby preventing users of drug delivery devices from accessing contaminant-free medication. The remote server may communicate with the medical professional in response to a communication from the medication administration device. The customer may initiate any desired modifications, such as contacting the user or initiating an order for a replacement medication holder. Alerts medical professionals to the status of medication delivery devices so they can take corrective action The device may be configured to:

[0150] The at least one sensor may include a moisture sensor, and the processor may When data is received from the sensor indicating that a critical level of moisture has been detected within the housing The moisture may be configured to modify the operation of the medication delivery device. A malfunctioning medication delivery device can cause the electrical components of the device to malfunction. By determining the presence of moisture within the housing, the medication delivery device This may improve the safety of the user.

[0151] The at least one sensor includes a first moisture sensor at a first location within the housing and a second moisture sensor at a second location within the housing. and a second moisture sensor located at a second position within the housing. Typically, the housing has multiple internal sections, each of which is connected to the other internal sections. Since different internal portions contain different components, each internal portion can be sealed off from the other. The effects of moisture contamination within a section can vary, for example, within different internal sections, within the housing, By having multiple moisture sensors at different locations, the medication delivery device can detect moisture contamination. In addition to the first and second moisture sensors, an additional moisture sensor ( There may be multiple

[0152] The location of the moisture sensor may be, for example, near water that may affect the safety of the removable power supply. Intrusions can be detected in the removable power supply, the processor, and therefore in the medication administration device. Moisture intrusion that can damage the electrical system can be detected near processors, motors, and This may include adjacent to the delivery mechanism, outside of the medication holder adjacent to the medication holder, or within the medication holder. do.

[0153] Each of the first moisture sensor, the second moisture sensor, and any additional moisture sensors , so that contaminants in one area cannot move freely to the other area. The different internal portions may be arranged in areas of the drug administration device that are separated by a distance, e.g. There is some obstruction to the flow of contaminants between the areas, such as being sealed off between them. The moisture sensor will measure a separate area of ​​the medication delivery device, so the choice of this location is important. This selection may provide efficient use of the moisture sensor.

[0154] The processor controls the medication delivery device in response to different locations of moisture contamination within the housing. The operation can be modified in different ways: By adapting the processor, moisture contamination due to their location within the housing is prevented. to limit functionality in relation to only those components of the drug delivery device that are directly affected by the The device may be configured to modify its operation.

[0155] The housing may include conductive traces, and the at least one sensor may be connected to the conductive traces. and a sensor configured to measure the conductivity of the conductive trace, particularly the conductivity along the conductive trace. Deviations in conductivity along the conductive traces may indicate changes in the integrity of the housing. The processor may be configured to detect the deviation using the conductivity measured from the sensor. If the housing is damaged, the inside of the housing is more likely to become contaminated, The sensor detects contamination in the housing before it is detected, as indicated by a deviation in the detected conductivity. The device may be configured to modify operation of the medication delivery device in response to damage to the housing. The conductive traces may be positioned across the joints within the housing. allows monitoring of areas of the housing that may be particularly sensitive to damage and the ingress of contaminants. To perform Noh.

[0156] The housing is configured to prevent electromagnetic radiation from interacting with the medication delivery device. The housing may include an electromagnetic shield, which reduces the risk of electromagnetic interference. It will be reduced.

[0157] The electromagnetic shield is placed around the entire housing to provide complete protection for the interior of the housing. Alternatively, the electromagnetic shield may be designed to protect only certain areas within the housing. These areas may require protection from electromagnetic interference or may be subject to This may be an area with particular components that are most likely to be adversely affected by the

[0158] The electromagnetic shield may be a passive electromagnetic shield or an active electromagnetic shield. The card may include, for example, sheet metal, metal screen, or metal foam. Dynamic electromagnetic shielding includes metallic ink or paint applied to the inside of the housing. Active electromagnetic shields include, for example, static or low-energy shields to offset the surrounding electromagnetic field volume. Examples include solenoids or Helmholtz coils configured to use high frequency electromagnetic shielding. It can be obtained.

[0159] In another exemplary embodiment, the drug administration device configured to administer the drug comprises a housing; and a dispensing mechanism disposed within the housing, the dispensing mechanism configured to dispense the medication. a removable device configured to power the medication administration device and to be received by the housing; and configured to measure a parameter indicative of a remaining charge of the removable power source; a first sensor configured to output data; and receiving data from the first sensor; and modifying operation of the medication administration device in response to data received from the first sensor. and a processor configured to:

[0160] The drug delivery device can be in the form of any of the drug delivery devices described herein.

[0161] The housing of the drug delivery device is the outer part of the drug delivery device. The housing of the chair is configured to keep contaminants out of the interior portions of the medication delivery device. and the internal portion of the medication delivery device includes all of the medication delivery device disposed within the housing. In particular, the housing is water-resistant in accordance with IEC standard 60529, e.g. IPX2, IPX3, IPX4, IPX5, IPX6, IPX7, IPX8 or higher The housing may be configured to have a waterproof property to the extent that the outer portion of the medication administration device is waterproof. and if the housing is constructed to be water-resistant or waterproof, A removable power source is received within the housing to provide adequate water resistance or waterproofing. When the power supply is connected to the power source, it may be coupled to a portion of the removable power source.

[0162] The drug holder of the drug administration device can be of any suitable form for holding a drug. As described herein, such suitable forms include a vial or a syringe.

[0163] The removable power source of the medication delivery device is a primary power source configured for single use only. Alternatively, the removable power source may be a secondary battery configured to be recharged. Primary batteries may include, for example, zinc-carbon batteries or alkaline batteries. The secondary battery may be, for example, a nickel-cadmium cell, a nickel-zinc cell, or a nickel Mention may be made of hydrogen cells or lithium ion cells.

[0164] The first sensor determines the remaining charge of the removable power source (e.g., its state of charge) and The data indicating the remaining battery level is used to output to a processor, for example. The sensor in step 1 is any sensor capable of measuring a parameter indicative of the charge state of the removable power source. One approach is to measure the voltage of the removable power supply and convert the measured voltage to The measured voltage is then correlated to the removable battery via a look-up table that correlates the charge state. The use of a sensor configured to convert the charge state of the power source. The lookup table may be stored in the memory of the drug administration device. Measure the current supplied by the removable power supply and transfer the measured current to the removable power supply. This utilizes a sensor configured to correlate the remaining expected charge. This is known as drug counting. The processor and memory of the drug delivery device A calculation can be performed to determine the expected state of charge.

[0165] The housing is adapted to receive a second power source configured to power the medication administration device. This second power source may be configured to provide drug administration in the absence of power from the removable power source. The power supply may be configured to power the power supply device in the absence of power from the removable power source. By allowing two power sources to be used, the drug delivery device is removable This power supply redundancy allows the power supply to be used by the user while the power supply is being replaced or recharged. The drug delivery device's removable power supply does not have enough power to allow the user to administer the drug. Avoid missed or late doses.

[0166] The drug administration device measures a parameter indicative of the remaining charge of the second power source (its state of charge). a second sensor configured to receive data from the second sensor; and modifying operation of the medication administration device in response to data received from the second sensor. The drug administration device and the user of the drug administration device may be configured to adapts to device usage by responding not only to the remaining charge of the primary power source but also to the remaining charge of the secondary power source. The second sensor may be particularly relevant for assessing the state of charge of the second power source. In conjunction with this, the first sensor may have any of the features associated with the first sensor described herein. do.

[0167] The second power source can be a primary battery. The primary battery can be, for example, a zinc-carbon battery or an alkaline battery. Primary batteries can be AA, AAA, C, E, or D batteries. The battery may be any commercially available primary battery having any standard size. This may allow the user to easily find alternatives to the second power source.

[0168] Alternatively, the second power source may be recharged, thereby , the secondary battery may be secondary, avoiding the need for the secondary battery to be replaced.

[0169] The drug administration device may include a second power source. The second power source is connected to a housing of the drug administration device. The sensor may be disposed within a housing.

[0170] The removable power source and / or the second power source may be connected to a power source, e.g., to be wirelessly charged. It can be configured to be charged without being physically connected. An example of wireless charging is inductive charging. Wireless charging can utilize the Qi standard or the PMA standard. By creating a battery, the drug delivery device may not require an external socket for charging. The ability to charge wirelessly eliminates the need for the medication delivery device to be physically connected to a power source for charging. This may reduce the time required to administer the medication. Because there is less handling of the device, wireless charging may also reduce the chance of contamination.

[0171] The second power source is connected to the removable power source when the removable power source is received within the housing. The second power source may be configured to receive charging from the removable power source. This allows the second power source to be automatically charged. This eliminates the risk that the user will forget to charge the second power source before it is fully charged. This reduces the risk of the medication delivery device running out of charge.

[0172] The second power source may be configured to power the drug administration device for a predetermined period of time and may be removable. The power source can go from no charge (fully discharged) to full charge (fully charged) within a given period of time. ) This configuration of the removable power source and the second power source. This allows the user to use only one removable power source for consistent use of the medication delivery device. This reduces the complexity of the drug delivery device and improves compliance. This can improve the performance.

[0173] Modifying the operation of the medication administration device may include causing the processor to consume the remaining charge of the removable power supply. and configured to initiate an alert when the amount reaches a first threshold level. The first threshold level is sufficient to cause the dispensing mechanism to dispense five extra doses of the medication. The first threshold level may be a threshold at which the dispensing mechanism dispenses four extra doses of the drug. The first threshold level may be sufficient charge to cause the dispensing mechanism to dispense three extra doses of the drug. The first threshold level may be sufficient charge to cause the dispensing mechanism to dispense more than two doses of the drug. The first threshold level may be sufficient charge to dispense a minute's dose of the drug. The charge may be sufficient to dispense one extra dose of the drug. raises an alert via the device indicators and / or user interface of the device The processor may be configured to initiate, for example, a communication interface of the medication administration device. Through the user interface, for example, the user may or may not own If not, the user can communicate with another wireless device that has a smartphone associated with it. The alert may be configured to initiate an alert when the medication administration device is full. Ensure that users take appropriate action to address low power charge levels before they run out of power. Make it possible.

[0174] The processor generates an alert when the remaining charge of the second power source reaches a second threshold level. The second threshold level may be configured to trigger the dispensing mechanism to administer five extra doses of the drug. The second threshold level may be sufficient charge to cause the dispensing mechanism to dispense four doses of the drug. The second threshold level may be sufficient charge to dispense an extra dose. The second threshold level may be sufficient charge to dispense three extra doses of the drug. The charge may be sufficient to cause the delivery mechanism to dispense two extra doses of the drug. The charge may be sufficient to cause the dispensing mechanism to dispense an extra dose of the medication. The processor may include a device indicator and / or a user interface for the medication administration device. The processor may be configured to initiate an alert via, for example, a medication administration device. The user can then communicate with the device via a communication interface, for example, or another wireless device that has a smartphone associated with the user. The device may be configured to initiate an alert by communicating with the device. , the user must be able to appropriately address the low power charge level before the medication delivery device runs out of charge. Allows you to take action.

[0175] The removable power source may include removable power source identification data. a removable power supply receiving unit configured to receive removable power supply identification data when the removable power supply is received within the housing; The processor may be configured to, in response to the removable power source identification data, identifying a power source compatible with the drug delivery device and storing a power source in the memory of the drug delivery device; and operating the medication administration device in response to the removable power source identification data not matching the source data. The removable power source identification data may be configured to modify the data storage component's The data storage component may be in communication with the processor. The data storage component may be in the form of a radio frequency identification (RFID) tag. The data storage component may be in the form of a bar code. The identification data is stored on a removable power source that utilizes several different forms of data storage components. By having a removable power supply that includes data, the drug The dispensing device may avoid the risk of damage resulting from an incompatible power input.

[0176] The drug administration device includes a component suitable for obtaining removable power source identification data. For example, if the removable power supply identification data is included as part of the RFID tag Obtaining the removable power supply identification data involves the use of an RFID scanner. A code scanner is useful when the removable power supply identification data is contained in the form of a bar code. When the removable power supply identification data is in the form of an integrated circuit, the integrated circuit may be used to identify the power supply. It may be possible for the power supply to transmit removable power source identification data. and acquiring the removable power supply identification data from the removable power supply identification data. US20130129033A1 - Use of a suitable communications interface to receive removable power supply identification data - Google Patents requires.

[0177] The removable power source may include a memory configured to receive data. The data may include usage data from the medication administration device, e.g., the amount of medication administered by the medication administration device. The dose and timing of administration may be controlled by a removable power source. If the memory configured to receive the data has a longer lifespan than the component, and (iii) allowing digital continuity to drug administration regimens administered by drug administration devices. This memory may be flash memory, one or more of a variety of random access Memory (RAM) (e.g., static RAM (SRAM), dynamic RAM (D RAM), or Synchronous DRAM (SDRAM), and / or combinations of memory technologies A combination may be mentioned.

[0178] The removable power supply is used to transfer data from other components of the medication delivery device, such as processor-generated data. The device may include a communications interface suitable for receiving data from the component(s). The data may be used, for example, when a removable power source is present as part of the drug administration device. For example, via direct electrical contacts, the device may be detachable from other component(s) of the drug delivery device. The power can be transmitted to a power source.

[0179] The distribution mechanism may be configured to be powered by a removable power source. The medication holder may be powered by a removable power source via an electric motor. If the removable power source is a device, the removable power source is a device for discharging a drug from a drug holder. An electric motor may be powered which powers a driver of the medication administration device for the plunger.

[0180] The dispensing mechanism may include a device motion prevention mechanism. The device manipulation prevention mechanism may be configured to prevent the dispensing mechanism from being removed. By preventing the dispensing mechanism from being powered by a reversible power source, operation of the dispensing mechanism can be prevented. The device operation prevention mechanism is configured to prevent the removable power source from being used to administer drugs to the removable power source. The protocol may be configured to be enabled when the protocol indicates incompatibility with a given device, e.g. The processor uses the removable power supply identification data to identify the removable power supply. Activating the device operation prevention mechanism upon determining compatibility with the drug delivery device The device may be configured to:

[0181] The device operation prevention mechanism detects when the charge remaining in the removable power supply falls below a third threshold level. When the power distribution mechanism is configured to prevent the power distribution mechanism from being powered by a removable power source, The third threshold level is sufficient power for the dispensing mechanism to complete the full drug delivery sequence. A complete drug administration sequence is a drug administration sequence in which the complete dose of the drug is administered. This prevents the drug delivery device from delivering a partial dose of the drug and allowing the patient to complete the drug regimen. The dispensing mechanism and / or If other part(s) involve mechanical movement during the drug administration sequence, e.g. includes extension of the needle outside the housing of the drug delivery device, the complete drug delivery sequence is It may also include returning the dispensing mechanism to its initial configuration.

[0182] The drug dispensing mechanism may be configured to be operated manually and / or automatically. To achieve this, power is required, such as from a removable power source. a drug delivery device including a pump or plunger accessible to a user of the drug delivery device; The pump or plunger dispenses a predetermined amount of medication from the medication holder. The pump or plunger may be configured to drive the drug to deliver the full dose of the drug. The drug dispensing mechanism may be spring loaded to ensure accurate dosing. By enabling the drug administration device to be used even when there is a power shortage, It can be done.

[0183] The device operation prevention mechanism detects that the remaining charge of the removable power supply exceeds the fourth threshold level. Sometimes, the dispensing mechanism may be configured to prevent manual operation. After all prescribed doses are delivered from the medication delivery device, the medication delivery device will When the user has This feature is useful when the drug delivery device is configured to deliver drugs susceptible to abuse. It is particularly suitable for drug administration devices when

[0184] Figure 9 shows an embodiment of a drug administration device 900 having multiple sensors. The device 900 is configured to power other components of the drug administration device 900. The removable power source 995 includes a first power electrical contact 946 and a second power supply electrical contact 947. As shown in FIG. When received within the housing 930 of the drug delivery device, the first and second power electrical connectors Points 946 and 947 are first and second housing electrical contacts 948 and 949, respectively. The removable power supply 995 is connected to the processor of the drug delivery device. The processor 996 is configured to power the drug delivery device. Controlling a motor 971 of the medication administration device, configured to power the distribution mechanism 970 The dispensing mechanism 970 is configured to dispense a drug from the drug holder 910 of the drug administration device. It is a driver for the plunger that drives the object. Medication holder 910 is a syringe.

[0185] First and second power supply electrical contacts 946, 947 and first and second housing electrical contacts 948 and 949 are a power supply 995 and a power supply 995 connected to the housing 995 of the drug administration device 900. 30, the power source 995 is configured to power the medication delivery device. The first and second power sources are configured to complete a circuit between the first and second power sources and the remainder of the device. The contacts 946, 947 and the first and second housing electrical contacts 948, 949 are made of metal. The first power supply electrical contact 946 may be the positive terminal of the power supply 995, and the second The second power supply electrical contact 947 may be the negative terminal of the power supply 995. 948 may be configured to receive the positive terminal 946 of the power supply 995, and the second housing The negative contact 949 may be configured to receive the negative terminal 947 of the power source 995 .

[0186] The drug delivery device 900 may be configured with a removable power supply compartment for the drug delivery device. The power supply 995 is located nearby and therefore accommodated in a removable power compartment a first moisture sensor 991 located near a removable power supply 995 when the and a second moisture sensor 992 located near the dispensing mechanism 970. The moisture sensor 991 and the second moisture sensor 992 detect whether the flow of contaminants between these regions is obstructed. The first and second moisture sensors 991 and 992 are located in a separate area. Moisture sensors suitable for use include hygrometers and / or water detectors. Quantitative hygrometer (measures the dielectric constant of polymers or metal oxides as it changes with humidity), resistance hygrometers (measures the electrical resistance of materials that changes with humidity), thermohygrometers (measures the electrical resistance of materials that changes with humidity) a gravimetric hygrometer (measures the change in the thermal conductivity of air as the mass of the air sample is mixed with an equal amount of dry air) These include hygrometers (which measure the absorption of light by water in the air) and optical hygrometers (which measure the absorption of light by water in the air). The water detector consists of two electrical contacts arranged close to each other and measures the resistance between the two contacts. and a resistance meter configured to measure a decrease in resistance when water is applied to the two contacts. and a processor (e.g., processor 996) can identify that water is present. .

[0187] The processor 996 receives data from the first moisture sensor 991 and the second moisture sensor 992. From this data, the processor 996 determines whether there is any moisture contamination. The processor 996 may be configured to determine the location of the moisture contamination. This allows the operation of the medication administration device 900 to be modified in response to location.

[0188] FIG. 10a is a schematic diagram of one embodiment of the housing electrical contacts and the power electrical contacts. The housing 1030 has a first housing electrical contact 1031 and a second housing electrical contact 1032. 032. The first housing electrical contact 1031 and the second housing electrical contact 103 2 is protected by the housing protection mechanism 1033 in its first configuration. The protection mechanism 1033 protects the first housing electrical contact 1031 and the second housing electrical contact A membrane sealing the point 1032. The membrane can be an impermeable membrane. The membrane can be made of an elastomeric material. The membrane may be made of silicone. The membrane may be made of rubber. The power supply 1095 may be It includes a first power supply electrical contact 1036 and a second power supply electrical contact 1037. The point 1036 and the second power electrical contact 1037 penetrate the housing protection mechanism 1033. The first power supply electrical contact 1036 and the second power supply electrical contact 1037 are , having sharp elements or features to penetrate the housing protection mechanism 1033 The housing protection mechanism 1033 may be configured to be penetrated. The ring protection mechanism 103 is configured to be penetrated by the first and second power supply electrical contacts. It may also include pre-formed openings or localized structural weaknesses. The point 1031 is configured to have a shape complementary to the first power electrical contact 1036, The second housing electrical contact 1032 has a shape complementary to the second power electrical contact 1037. The first and second electrodes are configured to contact each other, thus providing a sufficient contact area for the transmission of electrical current. and second power electrical contacts 1036, 1037 and first and second housing contacts 1031 , 1032, a power supply 1095 and a housing 1030 of the drug delivery device. a power source 1095 configured to power the drug delivery device when received within the device; The first and second power electrical contacts may be configured to complete a circuit between the first and second power electrical contacts and the remainder of the device. 1036, 1037 and the first and second housing contacts 1031, 1032 are made of metal. It can be made from materials.

[0189] FIG. 10b shows the housing electrical contacts 1031, 1032 and power supply voltage of the embodiment of FIG. 10a. 1037. The housing protection mechanism 1033 is a schematic diagram of the second The first power supply electrical contact 1036 and the second power supply electrical contact 1037 are connected to the housing. The first power supply electrical contact 1036 penetrates the protection mechanism 1033 and connects to the first housing electrical contact 1031, and a second power electrical contact 1037 is connected to the second housing. This allows contact with the electrical contacts 1032. The drug administration device of this embodiment , when the removable power supply 1095 is inserted into the housing 1030, From the first configuration we proceed to the second configuration depicted in Figure 10b. 1030, the first power supply electrical contact 1036 and the second power supply electrical contact Each of the contacts 1037 penetrates the housing protection mechanism 1033, displacing the membrane material and The housing protection mechanism 1033 is pressed into its second configuration. Because the membrane 1033 is elastic, When the removable power supply 1095 is subsequently removed from the housing 1030, From the second position (Fig. 10b) back to its first position (Fig. 10a). and / or a preformed hole configured to receive a second power electrical contact. The first and second power supply electrical contacts 1036, 1037 are connected to the removable power supply 1095. When initially received within the housing 1030 of the administration device, each membrane 1033 The first and second power supply electrical connectors may be configured to penetrate the membrane by piercing the first and second power supply electrical connectors. The points 1036, 1037 are then received within the housing 1030 of the medication delivery device. When the power supply is turned on, a voltage is formed on the membrane 1033 by first and second power supply electrical contacts 1036, 1037. The membrane 1033 may be pierced through holes in the housing 1030. It can extend over a

[0190] FIG. 11 shows the housing protection mechanism 1133 and the first power electrical contact in its first configuration. 1136. The housing protection mechanism 1133 is in the form of a slit having a width L1. The first power supply electrical contact 1136 includes a hole having a width L2. The width L2 is greater than the width L1. The housing protection mechanism 1133 is , so that it can be pressed into its second configuration by insertion of the first power electrical contact 1136, Made of an elastomeric material. The elastomeric material may be an elastomer. The elastomeric material may be a rubber. The elastomeric material may be a saturated rubber. The elastomeric material may be an unsaturated rubber. The elastomeric material may be a natural rubber. Examples include neoprene rubber, natural polyisoprene, polybutadiene, chloroprene, Nitrile rubber, styrene butadiene, nitrile rubber, ethyl propylene rubber, epichlorohydrin Phosphorus rubber, polyacrylic rubber, silicone rubber, fluorosilicone, fluoroelastomer mers, perfluoroelastomers, polyether block amides, chlorosulfonated poly Ethylene and ethylene vinyl acetate are examples of such materials. The first configuration has a smaller opening (slit) than the second configuration. This smaller size of the slit in the housing helps to direct contaminants towards the first electrical contact on the housing. Prevents the entry of

[0191] The first power supply electrical contact 1136 is connected to the removable power supply 1195 within the housing 1030. When received, the housing protection mechanism 1133 is configured to pass through a slit. Since the width L2 is greater than the width L1, the housing protection mechanism 1133 is removable. When the power supply 1195 is received within the housing, it is in a second position where it is under stress. The edge of the slit of the ring protection mechanism 1133 moves from its first configuration to its second configuration. When the power supply is removed, it moves across the surface of the first power supply electrical contact 1136. When the removable power supply 1195 is inserted into the housing of the medication delivery device, the first power supply The surface of the air contact 1136 is wiped by the housing protection mechanism 1133. Removal of the first power electrical contact 1136 from the housing protection mechanism 1133 releases the housing protection. The protection mechanism 1133 is allowed to return to the smaller width L1.

[0192] FIG. 12 illustrates a device configured to detect contamination within a drug holder 1210 of a drug administration device. 12 shows an embodiment of a drug administration device 1200 including the system. 12 includes an optical sensor 1294 positioned on one side of the medication holder 1210, The dispensing device 1200 is positioned opposite the medication holder 1210 and includes an optical sensor 129 4. The light sensor 1294 is connected to the processor 12 by a wire. 96. The processor 1296 receives data from the light sensor 1294 and The device is configured to determine from this data whether the medication holder 1210 contains a contaminant. The processor 1296 processes the data provided by the optical sensor 1294, e.g. , comparing the measured value with a threshold band as stored in the memory of the drug administration device 1200. may be configured to determine whether the medication holder 1210 contains a contaminant by If the data provided by the optical sensor 1294 falls outside the threshold band, the drug The drug delivery device 1200 may also be determined to contain a contaminant. The processor 1296 is configured to communicate with the LED 1299. , configured to turn on LED 1299 when contaminants are present in medication holder 1210. This illumination of the LED 1299 is intended to prevent the use of the medication delivery device 1200. Alert the user and remove the medication in the medication holder 1210, the medication administration device 1200, and / or The user is prompted to replace the medication holder 1210.

[0193] FIG. 13 shows a drug administration device 13 configured to be automatically and manually operable. 13 shows one embodiment of the drug delivery device 1300. The drug delivery device 1300 is an infusion pump. 1300 includes a medication holder 1310, a dispensing mechanism 1370, and a medication outlet 1320. The object holder 1310 is a syringe containing a vial and a plunger. It is configured to be operated by a manual pump 1350 or a motor 1371. The delivery mechanism 1370 drives a plunger in the medication holder 1310 to deliver the medication to the medication outlet 132. The infusion pump 1300 is configured to push the fluid from the infusion pump 1300. A removable power supply 1395 and a second power supply 1396 configured to power the external components. 94. The infusion pump 1300 also measures the remaining charge of the removable power supply 1395. The infusion pump 1300 includes a sensor 1392 configured to and configured to receive data and modify the operation of the infusion pump 1300 in response to the data. a processor 1396 configured to correct the power supply voltage; Not having enough charge to power the dispensing mechanism 1370 for a complete drug administration sequence If the data indicates that the motor 1371 is In such a situation, the distribution mechanism 137 The syringe pump 1350 may be operated by a manual pump 1350. The manual pump 1350 may be operated by a manual pump 1350. This allows only the drug to be administered. This allows the infusion pump 1300 to be used even if the power supply 1395 runs out of charge. do.

[0194] All of the devices and systems disclosed herein are designed to be disposed of after a single use. It may be designed to be used multiple times, or may be designed to be used multiple times. However, the device can be reconditioned for reuse after at least one use. Maintenance involves the steps of disassembling the device, followed by cleaning or replacing specific parts, and then This may include any combination of reassembly steps. Specifically, the device may be disassembled. and the ability to selectively replace any number of the particular pieces or portions of the device in any combination. When certain parts are cleaned and / or replaced, they can be removed for subsequent use. The device is reassembled at a reconditioning facility or by the surgical team immediately prior to surgery. Those skilled in the art will understand that reconditioning of a device requires disassembly, cleaning / replacement, and reassembly. It will be appreciated that various techniques are available for this purpose. The resulting reconditioned devices are all within the scope of the present application.

[0195] It may be preferable that the devices disclosed herein be sterilized before use. Examples of suitable methods include beta or gamma radiation, ethylene oxide, steam, and liquid baths (e.g., cold immersion). Sterilization can be accomplished by a variety of known methods. The embodiment is described in "System and Method" published on August 13, 2009. d Of Sterilizing An Implantable Medical This is described in more detail in U.S. Patent Publication No. 2009 / 0202387, entitled "A Novel Electromagnetic Wave Propagation Device." When implanted, the device is preferably completely sealed. This can be done by a variety of methods known to those skilled in the art.

[0196] The present disclosure is described through the examples only within the context of the entire disclosure provided herein. Within the spirit and scope of the claims appended hereto without departing from the overall scope of this disclosure. It will be understood that modifications may be made.

Claims

1. 1. A drug administration device configured to administer a drug, comprising: a housing, the housing including a first housing electrical contact and a second housing electrical contact; a housing including a ring electrical contact; a dispensing mechanism configured to dispense the drug, the dispensing mechanism comprising: a distribution mechanism disposed within the housing; a medication holder configured to hold the medication; a removable power source configured to power the medication administration device; The removable power supply includes a first power supply electrical contact and a second power supply electrical contact. With a source, The housing includes a housing protection mechanism, the housing protection mechanism comprising: When the removable power source is not received within the housing, the first housing a first configuration configured to protect the housing electrical contacts; When the removable power source is received within the housing, the first housing between the housing electrical contact and the first power supply electrical contact, and between the second housing electrical contact and the front a second configuration configured to allow contact between the second power supply electrical contact and the second power supply electrical contact; It is composed of and / or The removable power supply includes a power protection mechanism, the power protection mechanism comprising: When the removable power source is not received within the housing, the second power source a first arrangement configured to protect the electrical contacts; When the removable power source is received within the housing, the first housing between the housing electrical contact and the first power supply electrical contact, and between the second housing electrical contact and the front a second configuration configured to allow contact between the second power supply electrical contact and the second power supply electrical contact; 1. A drug administration device comprising:

2. The medication delivery device of claim 1 , wherein the housing includes a housing protection mechanism. Chair.

3. The removable power supply comprises a protective mechanism for the removable power supply. Item 3. A drug administration device according to item 2.

4. The housing protection mechanism in the first configuration is configured to surround the first housing electrical contact. The drug administration device according to any one of claims 1 to 3, wherein a sealing portion is formed therebetween.

5. The housing protection mechanism in the first configuration surrounds the second housing electrical contact.

5. The drug delivery device of claim 4, wherein the seal is formed on the outer surface of the drug delivery device.

6. The housing protection mechanism includes a membrane, and the first power supply electrical contact is connected to the removal the membrane is in the second configuration when a power source is received within the housing. The drug delivery device of claim 4 , wherein the membrane is configured to penetrate the membrane.

7. The first power supply electrical contact and the second power supply electrical contact are respectively connected to the removable power supply. a source disposed within the housing such that the membrane is in the second configuration when the source is received within the housing; The drug delivery device of claim 5 , configured to penetrate the membrane.

8. The power supply protection mechanism in the first configuration includes a seal around the second power supply electrical contact. The drug administration device according to any one of claims 1 to 3,

9. The power supply protection mechanism in the first configuration includes a seal around the first power supply electrical contact. The drug delivery device of claim 8 .

10. The power protection mechanism includes a membrane, and the second housing electrical contact is connected to the removable such that the membrane is in the second configuration when a power source is received within the housing. The drug delivery device of claim 8 , configured to pierce the membrane.

11. The first housing electrical contact is adapted to connect the removable power source to the housing. configured to penetrate the membrane such that the membrane is in the second configuration when the 10. The drug administration device of claim 9,

12. The housing protection mechanism in the first configuration is configured to surround the first housing electrical contact. a sealing portion is formed around the second power supply electrical connector, and the power supply protection mechanism in the first configuration is A drug delivery device according to any one of claims 1 to 3, which forms a seal around the point.

13. The housing protection mechanism and the power supply protection mechanism each include a membrane, and the first power supply protection mechanism The power source electrical contact and the second housing electrical contact are respectively said membranes being in said second configuration when received within said housing; 13. The drug administration device of claim 12, configured to penetrate a corresponding membrane.

14. The housing protection mechanism is configured to protect the removable power supply when the removable power supply is inserted into the housing. contacting the removable power source when the power supply is in the first configuration to the second configuration The drug administration device according to any one of claims 1 to 13, Chair.

15. The housing protection mechanism is configured to move along the surface of the first housing electrical contact.

15. The drug administration device of claim 14, wherein the drug administration device is configured as follows:

16. The housing protection mechanism is configured to change the housing protection mechanism from the first configuration to the second configuration. When moved to the configuration, the second housing is configured to move along a surface of the electrical contact.

16. The drug administration device of claim 15,

17. The power supply protection mechanism prevents the removable power supply from being damaged when inserted into the housing. contacting the housing to move from the first configuration to the second configuration; The drug administration device according to any one of claims 1 to 16, configured as follows:

18. The power supply protection mechanism is configured to move along a surface of the first power supply electrical contact.

18. The drug administration device of claim 17,

19. The power protection mechanism is configured to: and configured to move along a surface of the second power supply electrical contact when the second power supply electrical contact is pressed against the surface of the second power supply electrical contact. Item 19. A drug administration device according to item 18.

20. The first housing electrical contact, the second housing electrical contact, the first power supply electrical At least one of the contact and the second power electrical contact is provided with a hydrophobic conductive coating. The drug administration device according to any one of claims 1 to 19, which is coated with a coating. 。

21. within the housing configured to detect an environmental parameter within the housing. and a processor, wherein the processor detects the at least one sensor located at the receiving data from at least one sensor, and configured to modify the operation of the medication administration device in response to the data. The drug administration device of any one of claims 1 to 20, further comprising a processor.

22. 22. The medication delivery device of claim 21, wherein the at least one sensor includes a moisture sensor. Chair.

23. 23. The method of claim 21 or claim 22, wherein the at least one sensor includes a temperature sensor. Drug administration device.

24. The drugs include infliximab, golimumab, ustekinumab, daratumumab, and gusel. A small number of cumab, epoetin alfa, risperidone, and paliperidone palmitate A drug administration device according to any one of claims 1 to 23, comprising at least one

25. 1. A drug administration device configured to administer a drug, comprising: Housing and a dispensing mechanism configured to dispense the drug, the dispensing mechanism comprising: a distribution mechanism disposed within the housing; a medication holder configured to hold the medication; within the housing configured to detect an environmental parameter within the housing. at least one sensor located a processor, the processor receiving data from the at least one sensor; and transmitting the medication administration device in response to the data received from the at least one sensor. and a processor configured to modify the operation of the device. vinegar.

26. Claims 21 to 2, wherein the at least one sensor includes at least one contamination sensor.

6. A drug administration device according to any one of claims 5.

27. 27. The method of claim 26, wherein the at least one contamination sensor comprises a moisture sensor or an optical sensor. The drug delivery device.

28. The at least one contamination sensor includes an optical sensor, the optical sensor detecting the drug hormone. and the processor is configured to detect light received from the light sensor. determining whether the medication holder contains a contaminant based on the collected data.

28. The drug administration device of claim 27, wherein

29. The medication holder is configured to detect at least the wavelength of light that the optical sensor is configured to detect.

29. The drug delivery device of claim 28, which is transparent to

30. The optical sensor further comprises a light source configured to illuminate the medication holder. configured to detect the light from the source after the light passes through the medication holder.

30. A drug administration device as claimed in claim 28 or claim 29.

31. The processor, in response to the data received from the at least one sensor, initiating limp mode operation, said limp mode operation being initiated when contaminants are present; including reduced functionality when determined to do so; indicating the status of the medication administration device to a user; Preventing actuation of the medication delivery device when a contaminant is determined to be present. and / or When a contaminant is determined to be present, the previous Any of claims 21 to 30, configured to modify the operation of the medication administration device. A drug administration device as described in any one of claims 1 to 4.

32. The at least one sensor includes a moisture sensor, and the processor receiving data from the moisture sensor indicating that moisture contamination has been detected within the housing; configured, upon receipt, to modify the operation of the medication administration device. A drug administration device according to any one of claims 21 to 31.

33. The at least one sensor includes a first moisture sensor located at a first position within the housing. and a second moisture sensor at a second location within the housing.

33. A drug administration device according to any one of claims 1 to 32.

34. The processor receives data from the first moisture sensor and the second moisture sensor. and determining a location of moisture contamination within the housing from the data.

34. The drug administration device of claim 33.

35. The processor adjusts the medication dose in response to different locations of moisture contamination within the housing.

35. The method of claim 34, wherein the method is configured to modify the operation of a given device in different ways. Drug administration device.

36. The housing includes conductive traces, and the at least one sensor is 36. The method of claim 1, further comprising: measuring the conductivity of the conductive trace; A drug administration device as described in any one of claims 1 to 4.

37. the conductive traces are positioned across joints within the housing.

37. The drug administration device of claim 36.

38. The housing is configured to prevent electromagnetic radiation from interacting with the medication delivery device. A medication delivery device according to any one of claims 1 to 37, comprising an electromagnetic shield formed thereon. 。

39. The drugs include infliximab, golimumab, ustekinumab, daratumumab, and gusel. A small number of cumab, epoetin alfa, risperidone, and paliperidone palmitate A drug administration device according to any one of claims 1 to 38, comprising at least one

40. 1. A medication delivery device configured to deliver a medication, the device comprising: a housing; a dispensing mechanism configured to dispense the drug, the dispensing mechanism comprising: a distribution mechanism disposed within the housing; a removable power source configured to power the medication administration device, The housing is configured to receive the removable power source. and, a first sensor, the first sensor indicating a remaining charge of the removable power source; a first sensor configured to measure a parameter and output data; a processor, the processor receiving the data from the first sensor; the operation of the medication administration device in response to the data received from the first sensor. and a processor configured to modify the

41. The housing receives a second power source configured to power the medication delivery device.

41. The drug administration device of claim 40, configured to accommodate

42. and a second sensor for determining a remaining charge of the second power source. the processor receives data from the second sensor and modifying the operation of the medication administration device in response to the data received from a second sensor; 42. The drug administration device of claim 41, configured to:

43. 43. The drug delivery device of claim 41 or 42, wherein the second power source is a primary cell. Chair.

44. The medication delivery device includes the second power source, the second power source being connected to the housing.

43. The drug administration device of claim 41 or claim 42, wherein the drug administration device is disposed within a

45. 45. The medication of claim 44, wherein the second power source is configured to be charged wirelessly. Dosing device.

46. The medication delivery device includes a removable power source received within the housing. and configured to charge the second power source using the removable power source.

46. ​​A drug administration device as claimed in claim 44 or claim 45.

47. The second power source is configured to power the medication delivery device for a predetermined period of time. and the removable power source is capable of being charged from no charge to a full charge within the predetermined period of time. The drug administration device according to any one of claims 44 to 46, Chair.

48. Modifying the operation of the medication administration device may include: and configured to initiate an alert when the remaining charge of the power source reaches a first threshold level.

48. The drug administration device according to any one of claims 40 to 47, comprising:

49. The processor may be configured to:

49. The medicament of any one of claims 40 to 48, configured to initiate an alert. Drug administration device.

50. The removable power source includes removable power source identification data, and the processor When the removable power source is received in the housing, the removable power source identification and a processor configured to receive data from the removable power source identification. configured to modify the operation of the medication administration device in response to the data.

50. A drug administration device according to any one of claims 40 to 49.

51. the removable power source further includes a memory configured to receive data. Item 51. A drug administration device according to any one of items 40 to 50.

52. the distribution mechanism is configured to be powered by the removable power source.

52. A drug administration device according to any one of claims 40 to 51.

53. The dispensing mechanism according to any one of claims 40 to 52, wherein the dispensing mechanism includes a device operation prevention mechanism. The drug delivery device.

54. Modifying the operation of the medication administration device includes modifying the removable power source identification data. indicates that the removable power source is not compatible with the medication administration device; The device operation prevention mechanism is configured to prevent the distribution mechanism from being powered by the removable power source. and when directly or indirectly dependent on claim 50, including making it possible to prevent 54. The drug delivery device of claim 53.

55. The device operation prevention mechanism is configured to prevent the remaining charge in the removable power source from exceeding a third threshold level. When the temperature drops below a certain level, the distribution mechanism is powered by the removable power source.

55. A medication delivery device as claimed in claim 53 or claim 54, configured to prevent

56. The third threshold level is a threshold at which the dispensing mechanism receives sufficient fluid to complete a complete drug delivery sequence.

56. The drug delivery device of claim 55, which is coulometric.

57. 57. The method of claim 40, wherein the drug dispensing mechanism is configured to be manually operated. A drug administration device as described in any one of claims 1 to 4.

58. The device operation prevention mechanism is configured to prevent the remaining charge of the removable power source from reaching a fourth threshold level. and configured to prevent the dispensing mechanism from being manually operated when the threshold is exceeded. The drug administration device according to claim 57 when directly or indirectly dependent on claim 53, vinegar.

59. The drugs include infliximab, golimumab, ustekinumab, daratumumab, and gusel. A small number of cumab, epoetin alfa, risperidone, and paliperidone palmitate 60. A drug administration device according to any one of claims 40 to 59, comprising at least one

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