Composition for inactivating non-enveloped viruses

Abstract

To provide a virus inactivation composition having a high inactivating effect against non-enveloped viruses.SOLUTION: A composition for inactivating non-enveloped viruses, comprising (a) monoethanolamine, (b) an aromatic alcohol, and water, and having a pH of 10.5 or more and 14 or less at 25°C.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a composition for inactivating non-enveloped viruses, a method for inactivating non-enveloped viruses using the composition, and a wipe-cleaning sheet. [Background technology]

[0002] Non-enveloped viruses such as norovirus do not have a lipid membrane (envelope) on their surface, but are composed of capsid proteins that form a hydrophobic core. Therefore, many viruses are difficult to destroy with ethanol or soap, and are difficult to inactivate.

[0003] In recent years, there has been a demand for methods of inactivating non-enveloped viruses that are less irritating and corrosive and that can be used on textile products. Furthermore, the following techniques using aromatic alcohols have been disclosed.

[0004] Patent Document 1 discloses a technology in which an antibacterial agent comprising a combination of a quaternary ammonium salt and an organic solvent such as an aromatic alcohol has antibacterial activity against bacteria of the genus Methylobacterium. Patent Document 2 discloses a technique for a non-enveloped virus inactivating composition containing (a) a cationic surfactant, (b) an aromatic alcohol having a CLogP of 1.4 to 2.0, and water. Patent Document 3 discloses a technology for a cleanser composition that contains a quaternary ammonium salt surfactant and an alcohol-based solvent, has excellent virus inactivation effects, and is less irritating to the skin, and exemplified a composition that contains phenoxyethanol. Furthermore, Patent Document 4 discloses a technology for a bactericidal / virus inactivating composition containing an amine compound with an acid dissociation constant (pKa) of 9.0 or more and a cationic surfactant, and exemplifies a technology in which, although the effect of inactivating non-enveloped viruses is poor when used alone, the synergistic effect of a specific amine compound and a cationic surfactant can be used to inactivate non-enveloped viruses. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] Japanese Patent Application Laid-Open No. 2012-36179 [Patent Document 2] Japanese Patent Application Publication No. 2023-100511 [Patent Document 3] Patent Publication No. 2021-46533 [Patent Document 4] Japanese Patent Application Publication No. 2022-99966 Summary of the Invention [Problem to be solved by the invention]

[0006] The present invention provides a non-enveloped virus inactivating composition that has a high inactivating effect on non-enveloped viruses, as well as a method for inactivating non-enveloped viruses and a cleaning wipe using the same. [Means for solving the problem]

[0007] The present invention relates to a non-enveloped virus inactivating composition comprising (a) monoethanolamine (hereinafter referred to as component (a)), (b) an aromatic alcohol (hereinafter referred to as component (b)), and water, and having a pH of 10.5 or higher and 14 or lower at 25°C.

[0008] The present invention also relates to a method for inactivating non-enveloped viruses, which comprises contacting the non-enveloped virus inactivation composition with a target surface on which a non-enveloped virus is present or is suspected to be present.

[0009] The present invention also relates to a cleaning wipe comprising the non-enveloped virus inactivating composition and a nonwoven or woven fabric. [Effects of the Invention]

[0010] According to the present invention, there are provided a non-enveloped virus inactivating composition having a high inactivating effect on non-enveloped viruses, as well as a method for inactivating non-enveloped viruses and a wipe-cleaning sheet using the same. DETAILED DESCRIPTION OF THE INVENTION

[0011] In the present invention, virus inactivation may mean killing a virus or eliminating its infectivity. Furthermore, a virus inactivation effect means killing a part or all of a virus, or eliminating the infectivity, toxicity, or other activity of a virus.

[0012] [Non-enveloped virus inactivation composition] The non-enveloped virus inactivating composition of the present invention contains (a) monoethanolamine (hereinafter referred to as component (a)), (b) aromatic alcohol (hereinafter referred to as component (b)), and water, and has a pH of 10.5 or more and 14 or less at 25°C (hereinafter also referred to as the composition of the present invention).

[0013] <Component (a)> The non-enveloped virus inactivating composition of the present invention contains monoethanolamine, which is component (a) of the present invention.

[0014] <(b) Component> The non-enveloped virus inactivating composition of the present invention contains an aromatic alcohol, which is component (b) of the present invention. Component (b) may be one or more types.

[0015] The component (b) is preferably a monohydric aromatic alcohol or a polyhydric aromatic alcohol, and from the viewpoint of improving the effect of inactivating non-enveloped viruses, it is preferably a monohydric aromatic alcohol.

[0016] From the viewpoints of improving formulation suitability (ease of dissolving in water) and non-enveloped virus inactivation effect, component (b) preferably has a CLogP of 0.5 or more, more preferably 1 or more, and preferably 2.5 or less, more preferably 2 or less, even more preferably 1.5 or less, and even more preferably 1.4 or less. That is, from the viewpoint of improving the non-enveloped virus inactivation effect, component (b) may be a monohydric aromatic alcohol having a CLogP of preferably 0.5 or more, more preferably 1.0 or more, and preferably 2.5 or less, more preferably 2 or less, even more preferably 1.5 or less, and even more preferably 1.4 or less.

[0017] From the viewpoint of improving the non-enveloped virus inactivation effect, component (b) is an aromatic alcohol having a molecular weight of preferably 50 or more, more preferably 80 or more, and preferably 300 or less, more preferably 200 or less, and even more preferably 170 or less. That is, from the viewpoint of improving the non-enveloped virus inactivation effect, component (b) is a monohydric aromatic alcohol having a molecular weight of preferably 50 or more, more preferably 80 or more, and preferably 300 or less, more preferably 200 or less, and even more preferably 170 or less.

[0018] The component (b) is preferably a compound of the following general formula (b1):

[0019] [ka]

[0020] [In the formula, R 1b is a hydrocarbon group having 1 to 3 carbon atoms which may be bonded to a benzene ring via an oxygen atom, and R 2b is a hydrocarbon group having 1 or 2 carbon atoms which may be bonded to a benzene ring via an oxygen atom, and R 1b may bond to form a ring. n is the number 0 or 1. 1b and R 2b The total number of carbon atoms is 2 or more and 5 or less, preferably 2 or more and 3 or less.

[0021] The component (b) is, for example, the following aromatic alcohol (the numbers in parentheses are ClogP values): The component (b) is, for example, one or more selected from benzyl alcohol (1.104), 2-phenoxyethanol (1.188), 2-methylbenzyl alcohol (1.553), 3-methylbenzyl alcohol (1.603), 4-methylbenzyl alcohol (1.603), 1-phenyl-1-propanol (1.942), 1-(p-tolyl)ethanol (1.912), 1-hydroxyindan (1.518), 3-phenyl-1-propanol (1.712), cinnamyl alcohol (1.608), 2-phenylethanol (1.333), 2-hydroxyindan (1.218), and 1,2-dihydroxyindan (0.356), and from the viewpoint of blendability (ease of solubility in water), preferably one or more selected from benzyl alcohol (1.104) and 2-phenoxyethanol (1.188).

[0022] CLogP is an estimated value of the affinity of an organic compound for water and 1-octanol [P = (concentration of the organic compound in the 1-octanol phase) / (concentration of the organic compound in the aqueous phase)], and can be calculated using a calculation program that uses fragment values ​​of atomic groups determined by the number of atoms constituting the compound molecule and the type of chemical bond. In the present invention, CLogP calculated using ChemDraw ver. 22.2 from PerkinElmer is used.

[0023] The non-enveloped virus inactivating composition of the present invention contains component (a) in an amount of preferably 0.2% by mass or more, more preferably 0.5% by mass or more, even more preferably 0.7% by mass or more, still more preferably 1% by mass or more, and even more preferably 2% by mass or more, from the viewpoint of improving the non-enveloped virus inactivating effect, and preferably 10% by mass or less, more preferably 7% by mass or less, and even more preferably 4% by mass or less, from the viewpoint of suppressing the base odor of the composition and the white residue remaining on the surface of an object after wiping the surface with the composition of the present invention (hereinafter also referred to as "suppression of white residue after wiping").

[0024] The non-enveloped virus inactivating composition of the present invention contains component (b) in an amount of preferably 0.5% by mass or more, more preferably 1% by mass or more, even more preferably 2% by mass or more, and even more preferably 3% by mass or more in terms of improving the non-enveloped virus inactivating effect, and preferably 8% by mass or less, more preferably 5% by mass or less in terms of the base odor of the composition.

[0025] In the non-enveloped virus inactivating composition of the present invention, the total content of component (a) and component (b) is preferably 0.2% by mass or more, more preferably 1.0% by mass or more, more preferably 1.5% by mass or more, and even more preferably 2% by mass or more, in terms of improving the non-enveloped virus inactivating effect, and is preferably 18% by mass or less, more preferably 15% by mass or less, in terms of the base odor of the composition.

[0026] Furthermore, in the non-enveloped virus inactivating composition of the present invention, the total content of the aforementioned component (a) and component (b) in the composition is preferably 0.2 mass% or more and preferably 18 mass% or less, and the mass ratio of the content of component (a) to the content of component (b) [(a) / (b)] is preferably 0.01 or more, more preferably 0.1 or more, and preferably 20 or less, more preferably 5 or less, from the viewpoint of improving the non-enveloped virus inactivating effect.

[0027] <(c) component> The non-enveloped virus inactivating composition of the present invention may further contain an α-hydroxycarboxylic acid and / or a salt thereof having a molecular weight of 210 or less and one to two carboxyl groups, preferably an α-hydroxycarboxylic acid or a salt thereof having a molecular weight of 210 or less and one to two carboxyl groups, when the hydroxycarboxylic acid moiety excluding the salt moiety has an acid structure, in order to inhibit discoloration due to corrosion of metals (e.g., aluminum) that come into contact with the non-enveloped virus inactivating composition (hereinafter also referred to as "metal corrosion inhibition"), to suppress white residue after wiping, and to improve non-enveloped virus inactivation effects. In the present invention, the α-hydroxycarboxylic acid and / or a salt thereof is used as component (c). The α-hydroxycarboxylic acid is a mono- or polycarboxylic acid having one or more hydroxyl functional groups, at least one of which is introduced at the α-position of the acid (the carbon adjacent to the carboxyl functional group).

[0028] Component (c) has a molecular weight of 210 or less and has one to two carboxyl groups. The α-hydroxycarboxylic acid (number of carboxyl groups, molecular weight) is one or more selected from the group consisting of lactic acid (1, 90.08), malic acid (2, 134.09), methyllactic acid (1, 104.11), phenyllactic acid (1, 166.18), mandelic acid (1, 152.14), glycolic acid (1, 76.05), tartronic acid (2, 120.06), tartaric acid (2, 150.09), gluconic acid (2, 196.16), and salts thereof. The salt of the α-hydroxycarboxylic acid of component (c) may be an inorganic salt or an organic salt.

[0029] From the viewpoints of inhibiting metal corrosion, suppressing white residue after wiping, and improving the effects of inactivating non-enveloped viruses, component (c) is preferably one or more selected from lactic acid, malic acid, tartaric acid, and salts thereof, and more preferably one or more selected from malic acid, tartaric acid, and salts thereof.

[0030] In the present invention, when the counter ion of component (c) is monoethanolamine, the monoethanolamine counter ion of component (c) is classified as component (a) when the pH of the non-enveloped virus inactivating composition of the present invention is within the range of the present invention.

[0031] When the non-enveloped virus inactivating composition of the present invention contains component (c), from the viewpoints of inhibiting metal corrosion, suppressing white residue after wiping, and improving non-enveloped virus inactivation effects, the component (c) is contained in the composition in an amount of preferably 0.01% by mass or more, more preferably 0.04% by mass or more, even more preferably 0.08% by mass or more, and preferably 2% by mass or less, more preferably 1% by mass or less, and even more preferably 0.8% by mass or less. The concentration of component (c) is calculated as the acid form.

[0032] <(d) component> The non-enveloped virus inactivating composition of the present invention may further contain a surfactant in order to improve the cleaning properties of the composition on target surfaces (hereinafter also simply referred to as "cleaning properties"), metal corrosion inhibition, and non-enveloped virus inactivation effects. In the present invention, the surfactant is defined as component (d). Component (d) is preferably one or more surfactants selected from anionic surfactants, nonionic surfactants, amphoteric surfactants, and cationic surfactants.

[0033] The anionic surfactant is, for example, one or more selected from aromatic sulfonates having a hydrocarbon group with from 8 to 18 carbon atoms, alkyl or alkenyl ester sulfates having an alkyl or alkenyl group with from 8 to 18 carbon atoms, polyoxyalkylene alkyl or alkenyl ether sulfates having an alkyl or alkenyl group with from 8 to 18 carbon atoms, and fatty acid salts having from 8 to 18 carbon atoms.

[0034] The aromatic sulfonate salts have, for example, a hydrocarbon group, preferably an alkyl group, having 8 or more carbon atoms, preferably 10 or more carbon atoms, and 18 or less, preferably 14 or less carbon atoms. Examples of aromatic sulfonate salts include alkylbenzene sulfonate and alkyldiphenyl ether sulfonate salt. The alkyl or alkenyl sulfate ester salts have, for example, an alkyl or alkenyl group having 8 or more carbon atoms, preferably 10 or more carbon atoms, and 18 or less, preferably 14 or less carbon atoms. The polyoxyalkylene alkyl or alkenyl ether sulfate ester salts have, for example, an alkyl or alkenyl group having 8 or more carbon atoms, preferably 10 or more carbon atoms, and 18 or less, preferably 14 or less carbon atoms. The polyoxyalkylene alkyl or alkenyl ether sulfate ester salts have, for example, an oxyalkylene group having preferably 2 or 3 carbon atoms, more preferably 2 carbon atoms, and an average addition mole number of the oxyalkylene group of 0.5 or more, more preferably 1.0 or more, and 4.0 or less, preferably 3.0 or less. The number of carbon atoms in the fatty acid salt is, for example, 8 or more, preferably 10 or more, and 18 or less, preferably 14 or less. The salts of these anionic surfactants are, for example, alkali metal salts such as sodium salts and potassium salts, or ammonium salts.

[0035] The nonionic surfactant is, for example, one or more nonionic surfactants selected from amine oxide surfactants, glycoside nonionic surfactants, polyoxyalkylene monoalkyl or alkenyl ether nonionic surfactants, polyhydric alcohol fatty acid ester or polyhydric alcohol alkyl ether nonionic surfactants, and alkanolamide nonionic surfactants. From the viewpoint of improving cleaning performance, suppressing white residue after wiping, and non-enveloped virus inactivation effects, it is preferably one or more selected from amine oxide surfactants and glycoside nonionic surfactants. The polyhydric alcohol fatty acid ester or polyhydric alcohol alkyl ether nonionic surfactants may contain a glycoside nonionic surfactant.

[0036] The amine oxide surfactant is, for example, an amine oxide having at least one alkyl or alkenyl group having from 8 to 18 carbon atoms, and the remaining hydrocarbon group of the amine oxide has from 1 to 3 carbon atoms, preferably a methyl group. The alkyl group may be a compound bonded to the amine via an amidopropyl group. For example, the surfactant is an alkyldimethylamine oxide or alkylamidopropyldimethylamine oxide having an alkyl group having from 8 to 18, preferably 14 to 12, carbon atoms, preferably a linear alkyl group.

[0037] From the viewpoint of improving cleaning performance, suppressing white residue after wiping, and non-enveloped virus inactivation effects, the glycoside nonionic surfactant is, for example, a glycoside nonionic surfactant having a hydrocarbon group, preferably an alkyl or alkenyl group, more preferably an alkyl group, having 8 or more carbon atoms, preferably 10 or more and 18 or less, preferably 14 or less, and having an average degree of monosaccharide condensation of preferably 1 or more, preferably 3 or less, more preferably 2 or less, and even more preferably 1.5 or less.

[0038] The glycoside-type nonionic surfactant is preferably a compound represented by the following general formula (1d): R 1d (OR 2d ) x G y (1d) [In the formula, R 1d represents a hydrocarbon group having 8 to 20 carbon atoms, and R 2d represents an alkylene group having 2 to 4 carbon atoms, G represents a residue derived from a monosaccharide having 5 or 6 carbon atoms, x represents a number whose average value is 0 to 5, and y represents a number whose average value is 1 to 3. 1d OR 2d The bond between G and the group (I) is preferably an ether bond or an ester bond.

[0039] In the above general formula (1d), R 1dFrom the viewpoint of improving the cleaning property, the suppression of white residue after wiping, and the non-enveloped virus inactivation effect, R is, for example, a hydrocarbon group having 8 or more carbon atoms, preferably 10 or more carbon atoms, and preferably 18 or less carbon atoms, more preferably 14 or less carbon atoms, preferably an alkyl or alkenyl group, more preferably an alkyl group. 2d The alkylene group represented by the formula (I) preferably has 2 carbon atoms. The structure of the residue derived from a sugar having 5 or 6 carbon atoms represented by G is determined, for example, by the monosaccharide or disaccharide or higher sugar used. G is preferably a residue derived from one or more monosaccharides selected from glucose, galactose, xylose, mannose, lyxose, arabinose, and fructose, and a residue derived from one or more disaccharides or higher selected from maltose, xylobiose, isomaltose, cellobiose, gentiobiose, lactose, sucrose, nigerose, turanose, raffinose, gentianose, and menzitose. Among these, preferred raw materials are, for example, one or more monosaccharides selected from glucose and fructose, and one or more disaccharides or higher selected from maltose and sucrose, in terms of detergency, availability, and low cost.

[0040] In addition, x in the general formula (1d) is OR 2d is the average number of moles added, and is preferably 0 or more, and preferably 5 or less, more preferably 3 or less, further preferably 1 or less, and may also be 0.

[0041] Furthermore, when the average value of y in the above general formula (1d) is greater than 1, i.e., when the glycoside-type nonionic surfactant has a sugar chain of disaccharide or more as the hydrophilic group, the sugar chain bond type may be 1-2, 1-3, 1-4, 1-6 bond, or α-, β-pyranoside bond, furanoside bond, or any mixture of these bond types.

[0042] The average value of y in the general formula (1d) is, for example, 1 or more and, for example, 3 or less, preferably 2 or less, more preferably 1.5 or less. The value of y (average degree of condensation of sugars) is1 The measurement is performed by H-NMR. For a specific measurement method, reference can be made to the method described in JP-A-8-53696, page 6, column 10, line 26 to page 7, column 11, line 15.

[0043] The polyoxyalkylene monoalkyl or alkenyl ether type nonionic surfactant is preferably a compound represented by the following general formula (2d): R 3d O-(AO) n -H (2d) [In the formula, R 3d represents an alkyl or alkenyl group having 8 to 20 carbon atoms, AO represents an alkyleneoxy group having 1 to 3 carbon atoms, and n represents the average number of moles of AO added, which is a number of 1 to 20.

[0044] In general formula (2d), R 3d From the viewpoint of improving the cleaning property, the suppression of white residue after wiping, and the non-enveloped virus inactivation effect, the number of carbon atoms in R is preferably 10 or more, more preferably 12 or more, and is preferably 18 or less, more preferably 16 or less, and even more preferably 14 or less. 3d is an alkyl group or an alkenyl group, preferably an alkyl group derived from a higher alcohol, more preferably a straight-chain or branched-chain alkyl group, and even more preferably an alkyl group derived from a straight-chain primary alcohol or a straight-chain secondary alcohol, from the viewpoints of improving cleansing performance, suppressing white residue after wiping, and inactivating non-enveloped viruses. In general formula (2d), AO is preferably an alkyleneoxy group having from 2 to 3 carbon atoms, more preferably an alkyleneoxy group having 2 carbon atoms, i.e., an ethyleneoxy group. In general formula (2d), n is preferably a number of 3 or more, more preferably 5 or more, and preferably 15 or less, more preferably 10 or less, from the viewpoints of improving cleansing performance, suppressing white residue after wiping, and inactivating non-enveloped viruses.

[0045] The polyhydric alcohol fatty acid ester nonionic surfactant or polyhydric alcohol alkyl ether nonionic surfactant is an ester or ether compound of a fatty acid or aliphatic alcohol having preferably 8 or more carbon atoms, more preferably 10 or more, even more preferably 12 or more, still more preferably 14 or more, and preferably 20 or less, more preferably 18 or less, and even more preferably 16 or less, with a polyhydric alcohol having 3 to 10 hydroxy groups in the molecule. The polyhydric alcohol is preferably a monosaccharide or oligosaccharide such as glycerin, polyglycerin, pentaerythritol, trimethylolpropane, sorbitan, or sucrose, or an alkylene oxide adduct thereof.

[0046] When the polyhydric alcohol fatty acid ester type or polyhydric alcohol alkyl ether type nonionic surfactant contains an alkyleneoxy group, preferably an ethyleneoxy group, the average number of moles added is preferably 3 or more, more preferably 5 or more, even more preferably 10 or more, still more preferably 15 or more, and preferably 30 or less, more preferably 25 or less. When the polyhydric alcohol fatty acid ester type or polyhydric alcohol alkyl ether type nonionic surfactant contains an alkyleneoxy group, preferably an ethyleneoxy group, the polyhydric alcohol fatty acid ester is preferably added between the alkanoyloxy group or alkenoyloxy group constituting the fatty acid ester and the polyhydric alcohol compound, and the polyhydric alcohol alkyl ether is preferably added between the alkyl ether group and the polyhydric alcohol compound.

[0047] The polyhydric alcohol fatty acid ester type or polyhydric alcohol alkyl ether type nonionic surfactant is preferably one or more selected from sorbitan fatty acid esters and polyoxyethylene sorbitan fatty acid esters.

[0048] From the viewpoints of improving detergency, suppression of white residue after wiping, and non-enveloped virus inactivation, the number of carbon atoms in the fatty acid moiety constituting the sorbitan fatty acid ester is preferably 8 or more, more preferably 10 or more, even more preferably 12 or more, even more preferably 14 or more, and preferably 20 or less, more preferably 18 or less, and even more preferably 16 or less. The fatty acid is preferably a saturated fatty acid or an unsaturated fatty acid, more preferably an unsaturated fatty acid. From the viewpoints of improving detergency, suppression of white residue after wiping, and non-enveloped virus inactivation, the average esterification degree of the sorbitan fatty acid ester is preferably 0.8 or more, more preferably 1 or more, and preferably 3 or less, more preferably 1.5 or less, and even more preferably 1, i.e., a monoester. Examples of sorbitan fatty acid esters include sorbitan monocaprylate, sorbitan monolaurate, and sorbitan monooleate. The sorbitan fatty acid ester preferably has a monoester structure as its main structure, but may also contain a diester or triester.

[0049] From the viewpoints of improving detergency, suppression of white residue after wiping, and non-enveloped virus inactivation effect, the number of carbon atoms in the fatty acid moiety constituting the polyoxyethylene sorbitan fatty acid ester is preferably 8 or more, more preferably 10 or more, even more preferably 12 or more, still more preferably 14 or more, and preferably 20 or less, more preferably 18 or less, and even more preferably 16 or less. The fatty acid is preferably a saturated fatty acid or an unsaturated fatty acid, more preferably an unsaturated fatty acid. From the viewpoints of improving detergency, suppression of white residue after wiping, and non-enveloped virus inactivation effect, the average degree of esterification of the polyoxyethylene sorbitan fatty acid ester is preferably 0.8 or more, more preferably 1 or more, and preferably 3 or less, more preferably 1.5 or less, and even more preferably 1, i.e., a monoester. The average number of moles of oxyethylene groups added in the polyoxyethylene sorbitan fatty acid ester is preferably 3 or more, more preferably 5 or more, even more preferably 10 or more, still more preferably 15 or more, and preferably 30 or less, more preferably 25 or less, from the viewpoints of improving cleansing properties, suppressing white residue after wiping, and inactivating non-enveloped viruses.

[0050] Examples of polyoxyethylene sorbitan fatty acid esters include polyoxyethylene (20) sorbitan monolaurate (saturated fatty acid having 12 carbon atoms, average number of moles of ethylene oxide (hereinafter sometimes referred to as EO) added = 20), polyoxyethylene (20) sorbitan monostearate (saturated fatty acid having 18 carbon atoms, average number of moles of EO added = 20), polyoxyethylene (6) sorbitan monooleate (monounsaturated fatty acid having 18 carbon atoms, average number of moles of EO added = 6), and polyoxyethylene (20) sorbitan monooleate (monounsaturated fatty acid having 18 carbon atoms, average number of moles of EO added = 20).

[0051] The alkanolamide nonionic surfactant is preferably one or more selected from fatty acid monoethanolamides and fatty acid diethanolamides. The number of carbon atoms in the fatty acid moiety (acyl group) of the fatty acid alkanolamide is preferably 8 or more, more preferably 12 or more, and preferably 18 or less, more preferably 16 or less.

[0052] The amphoteric surfactant is preferably one or more selected from sulfobetaine surfactants and carbobetaine surfactants, more preferably sulfobetaine surfactants, even more preferably sulfobetaine surfactants having a hydrocarbon group with 8 or more carbon atoms, further 10 or more carbon atoms, and 18 or less, further 14 or less, and even more preferably an alkyl group.

[0053] The amphoteric surfactant is preferably one or more selected from N-alkyl-N,N-dimethylacetic acid betaine, N-alkylamidopropyl-N,N-dimethylacetic acid betaine, N-alkyl-N,N-dimethyl-N-(2-hydroxysulfopropyl)ammonium sulfobetaine, N-alkyl-N,N-dimethyl-N-sulfopropylammonium betaine, N-alkylamidopropyl-N,N-dimethyl-N-(2-hydroxysulfopropyl)ammonium sulfobetaine, and N-alkylamidopropyl-N,N-dimethyl-N-sulfopropylammonium sulfobetaine, and more preferably N-alkyl-N,N-dimethyl-N-(2-hydroxysulfopropyl)ammonium sulfobetaine (the alkyl group in these compounds preferably has 8 or more carbon atoms, more preferably 10 or more carbon atoms, and preferably 18 or less, more preferably 14 or less carbon atoms).

[0054] The cationic surfactant is, for example, a quaternary ammonium salt surfactant. The quaternary ammonium salt surfactant is a quaternary ammonium salt cationic surfactant in which one or two of the groups bonded to the nitrogen atom are hydrocarbon groups, preferably having from 8 to 20 carbon atoms, more preferably from 10 to 18 carbon atoms, and even more preferably from 10 to 14 carbon atoms, and preferably an alkyl or alkenyl group, and the remainder are groups selected from the group consisting of alkyl groups having from 1 to 3 carbon atoms, hydroxyalkyl groups having from 1 to 3 carbon atoms, and arylalkyl groups (such as benzyl groups), and preferably groups selected from the group consisting of methyl groups, ethyl groups, and benzyl groups. Among these, from the viewpoint of imparting antibacterial properties, a quaternary ammonium salt type cationic surfactant having a benzyl group is preferred.

[0055] From the viewpoint of improving cleaning properties, antibacterial properties, and non-enveloped virus inactivation effects, the quaternary ammonium salt-type cationic surfactant is preferably one or more quaternary ammonium salts selected from the group consisting of quaternary ammonium salts represented by the following general formula (11d) and quaternary ammonium salts represented by the following general formula (12d):

[0056] [ka]

[0057] [In the formula, R 11d is a hydrocarbon group having 8 to 20 carbon atoms, and R 12d and R 13d are each independently a group selected from an alkyl group having 1 to 3 carbon atoms and a hydroxyalkyl group having 1 to 3 carbon atoms, and X - is an anion.

[0058] [ka]

[0059] [In the formula, R 14d is a hydrocarbon group having 8 to 20 carbon atoms, and R15d is a group selected from a hydrocarbon group having 8 to 20 carbon atoms, an alkyl group having 1 to 3 carbon atoms, and a hydroxyalkyl group having 1 to 3 carbon atoms, and R 16d and R 17d are each independently a group selected from an alkyl group having 1 to 3 carbon atoms and a hydroxyalkyl group having 1 to 3 carbon atoms, and X - is an anion.

[0060] In general formula (11d), R 11d From the viewpoint of improving the cleaning property, antibacterial property, and non-enveloped virus inactivation effect, R is a hydrocarbon group, preferably an alkyl group or an alkenyl group, more preferably an alkyl group, having a carbon number of preferably 10 or more and preferably 18 or less, more preferably 16 or less. 12d , R 13d is preferably an alkyl group having 1 to 3 carbon atoms, more preferably an alkyl group having 1 to 2 carbon atoms, and even more preferably a methyl group. - is preferably a halogen ion such as a chloride ion, more preferably a chloride ion (Cl - )

[0061] In general formula (12d), R 14d From the viewpoint of improving the cleaning properties, antibacterial properties, and non-enveloped virus inactivation effect, R is a hydrocarbon group, preferably an alkyl or alkenyl group, more preferably an alkyl group, having a carbon number of preferably 8 or more, more preferably 10 or more, and preferably 18 or less, more preferably 16 or less, and even more preferably 14 or less. 15d is a hydrocarbon group having 8 to 20 carbon atoms, R 15d From the viewpoint of improving the cleaning properties, antibacterial properties, and non-enveloped virus inactivation effect, R is a hydrocarbon group, preferably an alkyl or alkenyl group, more preferably an alkyl group, having a carbon number of preferably 10 or more and preferably 18 or less, more preferably 16 or less, and even more preferably 14 or less. 15dis an alkyl group having 1 to 3 carbon atoms, R 15d is preferably an alkyl group having 1 to 3 carbon atoms, more preferably an alkyl group having 1 to 2 carbon atoms, and even more preferably a methyl group. 16d , R 17d are each independently a group selected from an alkyl group having 1 to 3 carbon atoms and a hydroxyalkyl group having 1 to 3 carbon atoms, preferably an alkyl group having 1 to 3 carbon atoms, more preferably an alkyl group having 1 to 2 carbon atoms, and even more preferably a methyl group. - is preferably a halogen ion such as a chloride ion, more preferably a chloride ion (Cl - )

[0062] When the non-enveloped virus inactivating composition of the present invention contains component (d), from the viewpoint of improving cleansing properties, antibacterial properties, and non-enveloped virus inactivating effects, the non-enveloped virus inactivating composition contains component (d) in an amount of preferably 0.01% by mass or more, more preferably 0.05% by mass or more, even more preferably 0.08% by mass or more, still more preferably 0.1% by mass or more, still more preferably 0.2% by mass or more, and preferably 5% by mass or less, more preferably 3% by mass or less, even more preferably 2% by mass or less, still more preferably 1% by mass or less, and still more preferably 0.5% by mass or less. When the non-enveloped virus inactivating composition of the present invention contains an anionic surfactant as component (d), the mass of the anionic surfactant is converted into the sodium salt.When the non-enveloped virus inactivating composition of the present invention contains a cationic surfactant as component (d), the mass of the cationic surfactant is converted into the chloride salt.

[0063] When the non-enveloped virus inactivating composition of the present invention contains component (d), from the viewpoint of improving cleaning properties, antibacterial properties, and non-enveloped virus inactivating effects, it preferably contains a quaternary ammonium-type cationic surfactant, more preferably a quaternary ammonium salt-type cationic surfactant having a benzyl group, and even more preferably an N-alkyl-N,N-dimethyl-N-benzylammonium salt.

[0064] When the non-enveloped virus inactivating composition of the present invention contains a quaternary ammonium surfactant as component (d), from the viewpoint of improving cleaning properties, antibacterial properties, and non-enveloped virus inactivating effects, the quaternary ammonium surfactant is contained in the composition in an amount of preferably 0.01% by mass or more, more preferably 0.05% by mass or more, even more preferably 0.08% by mass or more, still more preferably 0.1% by mass or more, still more preferably 0.2% by mass or more, and preferably 5% by mass or less, more preferably 3% by mass or less, even more preferably 2% by mass or less, still more preferably 1% by mass or less, and still more preferably 0.5% by mass or less. When the non-enveloped virus inactivating composition of the present invention contains a quaternary ammonium salt surfactant as component (d), the mass of the quaternary ammonium salt surfactant is expressed as a value converted to the chloride salt.

[0065] <(e) component> The non-enveloped virus inactivating composition of the present invention may further contain an inorganic alkaline agent from the viewpoint of improving the non-enveloped virus inactivating effect. In the present invention, the inorganic alkaline agent is referred to as component (e). The non-enveloped virus inactivating composition of the present invention may optionally contain component (e) when the inclusion of component (a) is not sufficient to adjust the pH of the composition at 25°C to 10.5 or higher and 14 or lower.

[0066] Component (e) is, for example, one or more selected from alkali metal hydroxides, alkali metal carbonates, and silicates. The alkali metal hydroxide is, for example, one or more selected from lithium hydroxide, sodium hydroxide, and potassium hydroxide, preferably one or more selected from sodium hydroxide and potassium hydroxide. The alkali metal carbonate is, for example, one or more selected from sodium carbonate, potassium carbonate, lithium carbonate, sodium bicarbonate, and potassium bicarbonate. The silicate is, for example, one or more selected from sodium silicate and potassium silicate, preferably one or more selected from sodium metasilicate, sodium orthosilicate, sodium silicate No. 1, sodium silicate No. 2, sodium silicate No. 3, sodium silicate No. 4, potassium silicate No. 1K, and potassium silicate No. 2K.

[0067] When the non-enveloped virus inactivating composition of the present invention contains one or more inorganic alkaline agents selected from alkali metal hydroxides and alkali metal carbonates (hereinafter also referred to as component (e1)) as component (e), the composition contains component (e1) in an amount of preferably 0.01% by mass or more, more preferably 0.05% by mass or more, even more preferably 0.1% by mass or more, and preferably 3% by mass or less, more preferably 2% by mass or less, and even more preferably 1% by mass or less, in order to improve the non-enveloped virus inactivating effect. When the non-enveloped virus inactivating composition of the present invention contains an alkali metal hydroxide as component (e), the remaining alkali metal ions not consumed by the counter ions derived from the acid contained in the aqueous composition are included in the content of component (e).

[0068] Furthermore, when the non-enveloped virus inactivating composition of the present invention contains a silicate (hereinafter also referred to as component (e2)) among the inorganic alkaline agents of component (e), from the viewpoints of inhibiting metal corrosion, suppressing white residue after wiping, and improving non-enveloped virus inactivation effects, the component (e2) is contained in the composition in an amount of preferably 0.001% by mass or more, more preferably 0.005% by mass or more, even more preferably 0.01% by mass or more, and preferably 1% by mass or less, more preferably 0.5% by mass or less, and even more preferably 0.1% by mass or less. Note that when the non-enveloped virus inactivating composition of the present invention contains component (e2) among the inorganic alkaline agents of component (e), the value used is calculated as the anhydrous sodium salt.

[0069] When the non-enveloped virus inactivating composition of the present invention contains component (e), the mass ratio of the content of component (a) to the content of component (e) [(a) / (e)] is, from the viewpoints of inhibiting metal corrosion, suppressing white residue after wiping, and improving the non-enveloped virus inactivating effect, preferably 0.1 or more, more preferably 0.5 or more, even more preferably 1 or more, still more preferably 5 or more, and preferably 500 or less, more preferably 100 or less, even more preferably 70 or less, and still more preferably 50 or less.

[0070] The non-enveloped virus inactivating composition of the present invention may contain a base other than component (a), component (b), optional component (c), optional component (d), optional component (e), and water. Such additives are compounds used in known virus inactivating compositions, and may include, for example, sequestering agents (excluding those corresponding to component (c)), short-chain alcohols, and glycol-based solvents.

[0071] <Component (f)> The non-enveloped virus inactivating composition of the present invention may further contain a sequestering agent (excluding those corresponding to component (c) of the present invention). In the present invention, the sequestering agent is defined as component (f). Component (f) is, for example, one or more selected from citric acid, ethylenediaminetetraacetic acid (EDTA), nitrilotriacetic acid (NTA), diethylenetriaminepentaacetic acid (DTPA), N-hydroxyethyl-ethylenediaminetriacetic acid (HEDTA), iminodiacetic acid, methylglycinediacetic acid (MGDA), glycine-N,N-diacetic acid derivatives, polyphosphoric acid, etidronic acid (HEDP), phosphonobutanetricarboxylic acid (PBTC), and alkali metal salts thereof. When the non-enveloped virus inactivating composition of the present invention contains component (f), the content of component (f) in the composition, calculated as the acid form, is preferably 0.005% by mass or more, more preferably 0.01% by mass or more, even more preferably 0.1% by mass or more, and preferably 5% by mass or less, more preferably 1% by mass or less, even more preferably 0.5% by mass or less.

[0072] <(g) component> When the non-enveloped virus inactivating composition of the present invention is used to wipe the surface of an object, the composition may further contain one or more solvents selected from monohydric or dihydric alcohols and glycol-based solvents (excluding those corresponding to component (b)) to ensure easy volatilization and excellent cleaning properties. In the present invention, one or more solvents selected from monohydric or dihydric alcohols and glycol-based solvents (excluding those corresponding to component (b)) are defined as component (g). Component (f) is preferably one or more solvents selected from methanol, ethanol, propanol, ethylene glycol, propylene glycol, diethylene glycol, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, propylene glycol monomethyl ether, and propylene glycol monoethyl ether, and more preferably one or more solvents selected from ethylene glycol monomethyl ether and propylene glycol monomethyl ether.

[0073] When the non-enveloped virus inactivating composition of the present invention contains component (g), the content of component (g) in the composition is preferably 0.05% by mass or more, more preferably 0.1% by mass or more, even more preferably 0.5% by mass or more, still more preferably 1% by mass or more, and preferably 20% by mass or less, more preferably 10% by mass or less, and even more preferably 5% by mass or less.

[0074] The non-enveloped virus inactivating composition of the present invention may contain, in addition to the above-mentioned components, enzymes (proteases, lipases, carbohydrate-splitting enzymes, etc.), hydrotropes other than the above-mentioned solvents such as sodium paratoluenesulfonate, dispersants such as polyacrylates, viscosity modifiers such as xanthan gum, colorants, antioxidants such as BHA, antibacterial and antifungal agents commercially available under the trade name Proxel BDN (trademark), known foam inhibitors such as silicones, bleaching agents such as hypochlorite and hydrogen peroxide, bleach activators, pH adjusters such as inorganic acids, ultraviolet absorbers, colorants, known fragrances, etc. (however, components corresponding to components (a), (b), (c), (d), (e), (f), and (g) are excluded) within the scope of the object of the present invention.

[0075] The non-enveloped virus inactivating composition of the present invention contains water. The water is not particularly limited, but is preferably tap water, well water, deionized water, distilled water, etc., and more preferably deionized water. The water preferably constitutes the remainder of the composition (amounts that total 100% by mass). The non-enveloped virus inactivating composition of the present invention contains water in an amount of preferably 85% by mass or more, more preferably 90% by mass or more, and preferably 99.9% by mass or less, more preferably 99.3% by mass or less, of the non-enveloped virus inactivating composition. Water may constitute the remainder of the composition.

[0076] The non-enveloped virus inactivating composition of the present invention has a pH at 25°C of, for example, 10.5 or higher, preferably 11 or higher, more preferably 12 or higher, still more preferably 12.5 or higher, and, for example, 14 or lower, preferably 13.5 or lower, more preferably 13 or lower from the viewpoints of suppressing white residue after wiping and improving the non-enveloped virus inactivating effect. In particular, this pH is determined by the following measurement method.

[0077] <Measurement method of pH> Connect a composite electrode for pH measurement (manufactured by Horiba, Ltd., glass sliding sleeve type) with the internal solution of the pH electrode being a saturated potassium chloride aqueous solution (3.33 mol / L) to a pH meter (pH / Ion Meter F-23 manufactured by Horiba, Ltd.). Next, fill 100 mL beakers with pH 4.01 standard solution (phthalate standard solution), pH 6.86 (neutral phosphate standard solution), and pH 9.18 standard solution (borate standard solution) respectively, and immerse them in a constant temperature bath at 25°C for 30 minutes. Immerse the pH measurement electrode in the standard solution adjusted to a constant temperature for 3 minutes, and perform calibration operations in the order of pH 6.86 → pH 9.18 → pH 4.01. Adjust the non-enveloped virus inactivating composition to be measured to 25°C, immerse the electrode of the above pH meter in the sample, and measure the pH after 1 minute.

[0078] The non-enveloped virus inactivating composition of the present invention may be used, for example, in a liquid, gel, or paste form. Depending on their usage forms, the non-enveloped virus inactivating composition of the present invention may appropriately contain a solubilizing carrier such as water, a solvent, a gelling agent, etc.

[0079] The non-enveloped virus inactivating composition of the present invention has a viscosity at 25°C of, for example, preferably 1 mPa·s or higher, more preferably 1.5 mPa·s or higher, still more preferably 2 mPa·s or higher, and preferably 10 mPa·s or lower, more preferably 8 mPa·s or lower, still more preferably 5 mPa·s or lower from the viewpoint of ease of wiping. This viscosity is measured with a B-type viscometer.

[0080] The viscosity is measured using a Brookfield viscometer, using one of rotors No. 1 to No. 3 that matches the viscosity of the sample, at 60 r / min, and the reading is the reading 1 minute after the start of measurement. The pH of the non-enveloped virus inactivating composition of the present invention is measured at a temperature adjusted to 25±1°C. If there are multiple rotors that satisfy the conditions, the value obtained using, for example, the rotor with the smaller number may be used.

[0081] Non-enveloped viruses targeted by the non-enveloped virus inactivation composition of the present invention include, for example, non-enveloped single-stranded (+)RNA viruses, single-stranded (-)RNA viruses, double-stranded RNA viruses, single-stranded DNA viruses, and double-stranded DNA viruses. Non-enveloped viruses targeted by the present invention include, for example, viruses belonging to the Caliciviridae, Picornaviridae, Parvoviridae, Papillomaviridae, Polyomaviridae, and Adenoviridae families. Examples of viruses with DNA genomes include adenoviruses, parvoviruses, papovaviruses, and human papillomaviruses, while those with RNA genomes include rotaviruses, coxsackieviruses, enteroviruses, sapoviruses, noroviruses, polioviruses, echoviruses, hepatitis A viruses, hepatitis E viruses, rhinoviruses, and astroviruses.

[0082] The non-enveloped virus inactivating composition of the present invention is intended for use, for example, on the body, such as human skin, fingers, hair, and the oral cavity; (2) on food, such as on the surface of food materials such as vegetables; (3) on hard articles; and (4) on textile products, such as textile materials such as cloth and thread, and products manufactured using them. Examples of hard articles include hard articles having a hard surface, such as bathrooms, toilets, kitchens, floors, doorknobs, tableware, food processing equipment, desks, chairs, and walls. These hard articles may be used in homes, public facilities, factories, such as swimming pools, bathhouses, cafeterias, hospitals, and livestock facilities. The non-enveloped virus inactivating composition of the present invention may be used on hard surfaces. That is, the non-enveloped virus inactivating composition of the present invention may be used on hard surfaces.

[0083] Hard surfaces to which the non-enveloped virus inactivating composition of the present invention is applied include, for example, floors, walls, ceilings, furniture, etc. in living areas such as living rooms, rooms, kitchens, bathrooms, toilets, etc. Furthermore, hard surfaces to which the non-enveloped virus inactivating composition of the present invention is applied are preferably hard surfaces such as floors, walls, ceilings, furniture, instruments, and devices in facilities that require a high level of hygiene management, such as hospitals or nursing homes.

[0084] [Method for inactivating non-enveloped viruses] The present invention provides a method for inactivating non-enveloped viruses, which comprises contacting a subject in which a non-enveloped virus is present or suspected to be present with a non-enveloped virus inactivation composition of the present invention. In the method for inactivating non-enveloped viruses of the present invention, the non-enveloped virus inactivation composition to be contacted with the subject may be the same as the specific examples and preferred aspects of the non-enveloped virus inactivation composition of the present invention described above.

[0085] In the method for inactivating non-enveloped viruses of the present invention, specific examples and preferred embodiments of the target surface with which the non-enveloped virus inactivating composition of the present invention is brought into contact may be the same as the target surface described for the non-enveloped virus inactivating composition of the present invention. That is, the present invention may be a method for inactivating non-enveloped viruses in which the non-enveloped virus inactivating composition of the present invention is brought into contact with a hard surface on which a non-enveloped virus exists or is thought to exist. In the method for inactivating non-enveloped viruses of the present invention, specific examples and preferred embodiments of the hard surface with which the non-enveloped virus inactivating composition of the present invention is brought into contact may be the same as the hard surface described for the non-enveloped virus inactivating composition of the present invention.

[0086] In the method for inactivating non-enveloped viruses of the present invention, a concentrated composition containing components (a) and (b) may be prepared in advance, and the concentrated composition may be diluted with water to prepare the non-enveloped virus inactivating composition of the present invention, which may then be brought into contact with the target surface. That is, the method for inactivating non-enveloped viruses may involve diluting a concentrated composition containing components (a) and (b) with water to prepare the non-enveloped virus inactivating composition of the present invention, and then contacting the non-enveloped virus inactivating composition without dilution with the target surface.

[0087] The time for which the non-enveloped virus inactivating composition of the present invention is brought into contact with the target surface (the time for which it is left standing) is preferably 30 seconds or longer, more preferably 1 minute or longer, even more preferably 5 minutes or longer, and preferably 120 minutes or shorter, more preferably 60 minutes or shorter, and even more preferably 10 minutes or shorter, from the viewpoint of improving the non-enveloped virus inactivation effect. After contact, the composition may be allowed to dry as is, wiped off with a clean cloth, or rinsed with water. When rinsing, an external force (physical force) may be applied with a sponge or the like, or simply rinsed with running water.

[0088] Methods for contacting the non-enveloped virus inactivating composition of the present invention with a target surface include spraying or applying the non-enveloped virus inactivating composition of the present invention to a target surface on which a non-enveloped virus is present or is thought to be present, and impregnating a non-woven or woven fabric with the non-enveloped virus inactivating composition of the present invention and contacting the non-enveloped virus inactivating composition with the target surface.

[0089] When the non-enveloped virus inactivating composition of the present invention is sprayed or applied to a target surface, the non-enveloped virus inactivating composition of the present invention may be filled into a container equipped with a sprayer and sprayed in the form of droplets or foam, or the non-enveloped virus inactivating composition of the present invention may be poured from the container onto the target surface and applied with a brush or the like. The container equipped with a sprayer may be a manual spray device that does not use a propellant, such as a trigger-type spray container or a pump-type spray container, or an aerosol that uses a propellant. The container equipped with a sprayer is preferably a trigger-type spray that can spray the contents in the form of droplets or foam, and more preferably a trigger-type spray equipped with a mechanism for spraying the contents in the form of droplets or a trigger-type spray equipped with a mechanism for forming foam (foam-forming mechanism).

[0090] When the non-enveloped virus inactivating composition of the present invention is impregnated into a non-woven fabric or a woven fabric and brought into contact with a target surface, the non-woven fabric or the woven fabric may be processed into a sheet.

[0091] That is, the method for inactivating non-enveloped viruses of the present invention may be, for example, a method for inactivating non-enveloped viruses by impregnating a non-woven or woven fabric and bringing it into contact with a target surface on which a non-enveloped virus exists or is thought to exist, preferably a hard surface on which a non-enveloped virus exists or is thought to exist.

[0092] Furthermore, the method for inactivating non-enveloped viruses of the present invention may involve, for example, contacting a nonwoven or woven fabric with a target surface on which a non-enveloped virus is present or is thought to be present, preferably a hard surface on which a non-enveloped virus is present or is thought to be present, and then pressing the nonwoven or woven fabric against the target surface and applying external force (rubbing, kneading, hitting, etc.) using a human hand or the like within a range that does not damage the target area.

[0093] [Wipe cleaning sheet] The present invention provides a cleaning wipe comprising the non-enveloped virus inactivating composition of the present invention and a nonwoven or woven fabric. In other words, the present invention provides a cleaning wipe comprising a nonwoven or woven fabric impregnated with the non-enveloped virus inactivating composition of the present invention. The present invention also provides a method for imparting antibacterial properties to a target surface, which comprises wiping the target surface with the cleaning wipe of the present invention. The target surface is preferably a hard surface. That is, the cleaning wipe of the present invention is suitable for use on hard surfaces.

[0094] Specific examples and preferred aspects of the non-enveloped virus inactivating composition of the wipe sheet of the present invention may be the same as those of the non-enveloped virus inactivating composition of the present invention described above. Specific examples and preferred aspects of the target surface with which the non-enveloped virus inactivating composition of the present invention comes into contact may be the same as those of the target surface and hard surface described for the non-enveloped virus inactivating composition of the present invention.

[0095] The nonwoven or woven fabric used in the wiping sheet of the present invention is processed into a sheet, and the fibers constituting the nonwoven or woven fabric are preferably composed of one or more fibers selected from hydrophilic fibers and hydrophobic fibers. In the present invention, hydrophilic fibers refer to fibers having a moisture regain under standard conditions (20°C, 65% RH) of more than 5%. The moisture regain under standard conditions is measured by the methods specified in JIS L1013 and JIS L1015. Hydrophobic fibers refer to fibers having a moisture regain under standard conditions (20°C, 65% RH) of 5% by mass or less.

[0096] Examples of hydrophobic chemical fibers include polyamide fibers (nylon, etc.), polyester fibers (polyester, etc.), polyacrylonitrile fibers (acrylic, etc.), polyvinyl alcohol fibers (vinylon, etc.), polyvinyl chloride fibers (polyvinyl chloride, etc.), polyvinylidene chloride fibers (vinylidene, etc.), polyolefin fibers (polyethylene, polypropylene, etc.), polyurethane fibers (polyurethane, etc.), and polyvinyl chloride / polyvinyl alcohol copolymer fibers (polycrelal, etc.), and these may be used alone or in combination of two or more types.

[0097] Hydrophilic fibers include seed fibers (cotton, cotton, kapok, etc.), bast fibers (hemp, flax, ramie, hemp, jute, etc.), leaf vein fibers (Manila hemp, sisal, etc.), palm fibers, rush, straw, animal hair fibers (wool, mohair, cashmere, camel hair, alpaca, vicuna, angora, etc.), silk fibers (domestic silk, wild silk), feathers, cellulosic fibers (rayon, polynosic, cupra, acetate, etc.), etc., and one or more of these may be used. However, hydrophilic fibers exclude hydrophilized polyester fibers (polyester fibers that have been hydrophilized and whose moisture regain under standard conditions falls within the range of hydrophilic fibers described below).

[0098] The basis weight of the nonwoven or woven fabric used in the present invention is preferably 10 g / m 2 More preferably, 20 g / m 2 or more, and preferably 100 g / m 2 Less than 80 g / m 2 More preferably 60 g / m or less 2 Below are the results.

[0099] The mass ratio of the non-enveloped virus inactivating composition of the present invention to the mass of the nonwoven or woven fabric (impregnation rate (mass %)) is preferably 100 mass % or more, more preferably 150 mass % or more, and preferably 250 mass % or less, more preferably 200 mass % or less. From the viewpoint of exerting a wiping effect, the impregnation rate is preferably 100 mass % or more, and from the viewpoint of preventing moisture from entering the interior of precision equipment such as keyboards, the impregnation rate is preferably 250 mass % or less. The impregnation rate is calculated using the following formula.

[0100] Impregnation rate (mass%) = [(mass of nonwoven or woven fabric impregnated with non-enveloped virus inactivating composition) / (mass of dry nonwoven or woven fabric) - 1] x 100

[0101] The method of wiping a target surface using the wiping and cleaning sheet of the present invention involves pressing the wiping and cleaning sheet of the present invention against the target surface and applying external force by hand or the like within a range that does not damage the area to be cleaned, thereby transferring dirt adhering to the area to be cleaned to the wiping and cleaning sheet, and this can be done by rubbing, kneading, or tapping. [Example]

[0102] The components used in the examples and comparative examples are listed below. The numbers in parentheses for component (b) and component (b') indicate the ClogP values.

[0103] <Component (a) and Component (a')> (a) Ingredients (a-1) Monoethanolamine: manufactured by Nippon Shokubai Co., Ltd. Component (a') (a'-1) Sodium carbonate: Fujifilm Wako Pure Chemical Industries, Ltd. <Component (b) and Component (b')> (b) Component (b-1) Benzyl alcohol (ClogP 1.104, molecular weight 108.14): Fujifilm Wako Pure Chemical Industries, Ltd. (b-2) 2-phenoxyethanol (ClogP 1.188, molecular weight 138.17): Fujifilm Wako Pure Chemical Industries, Ltd. (b') component (b'-1) Ethanol (ClogP-0.235, molecular weight 46.07): Fujifilm Wako Pure Chemical Industries, Ltd. (b'-2) Isopropyl alcohol (ClogP 0.074, molecular weight 60.1): Fujifilm Wako Pure Chemical Industries, Ltd.

[0104] (d) Ingredients (d-1) benzalkonium chloride (in the general formula (11d), R 11d is an alkyl group having 12 to 16 carbon atoms, and R 12d and R 13d is a methyl group, and X - is a quaternary ammonium salt, which is a chloride ion), product name: Sanisol B-50, manufactured by Kao Corporation

[0105] ·SM Buffer: 0.58%NaCl, 0.2%MgSO4·7H2O, 50mM Tris-HCl (pH7.5)

[0106] [Method for preparing a non-enveloped virus inactivating composition] A stirrer piece and deionized water were placed in a beaker, and while stirring the deionized water, component (a) (or component (a')) and component (b) (or component (b')) were added so as to achieve the contents shown in Tables 1 and 2. The mixture was stirred at room temperature (20°C) to dissolve, thereby preparing the non-enveloped virus inactivating compositions shown in Tables 1 and 2. In Comparative Examples 5 and 6 in Table 2, sodium hydroxide was added to adjust the pH to the values ​​shown in Tables 1 and 2. The pH was measured by the glass electrode method. The contents in Tables 1 and 2 are percentages by mass, and all are values ​​based on the active ingredient. The contents in Tables 1 and 2 were adjusted by the amount of deionized water, and for convenience, the content of deionized water is indicated as "balance."

[0107] [Evaluation of non-enveloped virus inactivation] (1) Preparation of bacterial suspension Escherichia coli NBRC 13965 (distributed by NBRC, hereafter referred to as E. coli) was inoculated onto standard agar medium (manufactured by Nissui Pharmaceutical) and cultured overnight at 37°C. 12 mL of LB medium (BD Difco LB Broth, Lennox) was dispensed into a cell culture flask, and the resulting single colony was suspended and cultured overnight with shaking at 37°C and 200 rpm. 12 mL of LB medium was dispensed into a new cell culture flask, and 100 μL of the resulting culture was added. Culture was continued at 37°C and 200 rpm until the OD600 reached 0.3-0.4, preparing a bacterial suspension for use in preparing double-plate agar medium.

[0108] (2) Preparation of double agar plates A lower agar plate was prepared by pouring 25 mL of autoclaved LB agar medium (agar concentration 1.5% by mass) into a square Petri dish (120 × 120 × 17 mm, Greiner Japan Co., Ltd.) and allowing it to cool and harden. 4.0 mL of the bacterial solution prepared in (1) above was added to 36 mL of autoclaved LB soft agar medium (agar concentration 0.6% by mass) that had been kept warm at 50°C, and the mixture was stirred quickly. 15 mL of this mixture was poured onto the previously prepared lower agar plate to prepare a double agar plate.

[0109] (3) Contact of the non-enveloped virus inactivating composition with the non-enveloped virus 1.0 × 10 IgG suspended in SM buffer was added to each 1.5 mL plastic tube containing 990 μL of the non-enveloped virus inactivation composition shown in Tables 1 and 2. 10 Ten microliters of Escherichia coli MS2 NBRC 102619 (distributed by NBRC, hereafter referred to as MS2) containing pfu / mL of Escherichia coli was added, stirred thoroughly, and then allowed to stand for 5 minutes to allow contact between the non-enveloped virus inactivation composition and MS2. A 100-microliter aliquot of the mixture was added to 900 microliters of neutralizing medium to terminate contact between the non-enveloped virus inactivation composition and MS2. The mixture was then mixed with the neutralizing medium and serially diluted (10- to 1,000,000-fold) with SM buffer to prepare samples for spot testing. A control sample was also prepared by the same procedure, using SM buffer instead of the non-enveloped virus inactivation composition.

[0110] (4) Evaluation of non-enveloped virus inactivation effect by spot test 5.0 μL of each sample prepared in (3) above was spotted onto the double agar plate prepared in (2) above and cultured overnight at 37° C. The dilution ratio at which death (plaques) of E. coli caused by viral infection was no longer observed was confirmed visually, and the non-enveloped virus inactivation effect of each impregnation solution before and after storage was evaluated by comparing with the results of the control sample and measuring the MS2 inactivation effect (ΔLog) value shown below.

[0111] The MS2 inactivation effect (ΔLog) is defined by the following formula: MS2 inactivation effect (ΔLog) = LogC-LogS C: The dilution ratio at which the death of E. coli in the control sample was no longer confirmed. S: Dilution ratio at which the death of E. coli in the test sample is no longer confirmed

[0112] The larger the value of the MS2 inactivation effect (ΔLog), the higher the non-enveloped virus inactivation effect of each non-enveloped virus inactivation composition. The results are shown in Tables 1 and 2.

[0113] [Table 1]

[0114] [Table 2]

[0115] [Production of a sheet impregnated with a non-enveloped virus inactivating composition] The non-enveloped virus inactivating compositions of Examples 1, 3, 6, and 9 in Table 1 were impregnated into the nonwoven fabric described below so that the impregnation rate, calculated using the following formula, was 200 mass %, to produce the wipe-cleaning sheets of the present invention.

[0116] Nonwoven fabric: Made by Taketora Co., Ltd. (product name: Centrarch II), containing polyethylene terephthalate (PET) fiber and rayon fiber in the base material, with a rayon fiber content of 70% by mass and a polyethylene terephthalate (PET) fiber content of 30% by mass, and a basis weight of approximately 30 g / m 2

[0117] Impregnation rate (mass%)=[(mass of nonwoven fabric impregnated with non-enveloped virus inactivating composition) / (mass of dry nonwoven fabric)−1]×100

[0118] These manufactured wiping sheets of the present invention left little white residue when used for wiping, and it was confirmed that they were excellent in removing non-enveloped viruses.

Claims

1. A non-enveloped virus inactivation composition comprising (a) monoethanolamine (hereinafter referred to as component (a)), (b) an aromatic alcohol (hereinafter referred to as component (b)), and water, and having a pH of 10.5 or higher and 14 or lower at 25°C.

2. 2. The non-enveloped virus inactivating composition according to claim 1, wherein component (b) is a monohydric aromatic alcohol having a CLogP of 0.5 or more and 2.5 or less.

3. The non-enveloped virus inactivating composition according to claim 1 or 2, wherein the content of component (b) is 0.5% by mass or more and 8% by mass or less.

4. The non-enveloped virus inactivating composition according to claim 1 or 2, further comprising (d) a surfactant (hereinafter referred to as component (d)).

5. The non-enveloped virus inactivating composition according to claim 1 or 2, wherein component (d) is a cationic surfactant.

6. The non-enveloped virus inactivating composition according to claim 1 or 2, which is for use on hard surfaces.

7. A method for inactivating non-enveloped viruses, comprising contacting the non-enveloped virus inactivating composition according to claim 1 or 2 with a target surface on which non-enveloped viruses are present or suspected to be present.

8. A cleaning wipe comprising the non-enveloped virus inactivating composition according to claim 1 or 2 and a nonwoven or woven fabric.

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