Two-region light protective preparation and method for producing two-region light protective preparation

Abstract

To provide a two-region light protective preparation that is capable of exhibiting protective functions against both ultraviolet light and near-infrared light, and a method for producing the two-region light protective preparation.SOLUTION: A two-region light protective preparation comprises a near-infrared protective agent containing an ultraviolet absorber. A method for producing the near-infrared protective agent includes: preparing a first mixed solution by mixing a nonionic surfactant, purified water, and an acrylic polymer; preparing a second mixed solution by mixing the first mixed solution with purified water; and further preparing a formulation by emulsifying the second mixed solution after mixing with an oil agent, wherein the oil agent contains the ultraviolet absorber in an amount such that the PA in the two-region light protective preparation is PA+ or higher and / or the SPF is 10 or higher.SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] The present invention relates to dual-domain photoprotective formulations and methods for making dual-domain photoprotective formulations. [Background technology]

[0002] BACKGROUND ART It has been known that exposure to sunlight outdoors can have adverse health and cosmetic effects on the skin.

[0003] For example, ultraviolet light (ultraviolet rays) promotes the formation of thymine dimers in the DNA of cells that make up the skin, affecting the process of replicating genetic information and potentially inducing cancer in cells.

[0004] In addition, melanin pigment is produced as one of the biological defense mechanisms to prevent such damage, but when the skin darkens and becomes sunburned, pigmentation may be deposited, which is also undesirable from a cosmetic point of view.

[0005] Therefore, in order to reduce the amount of ultraviolet light that reaches the skin, ultraviolet protection agents containing, for example, titanium oxide have been provided.

[0006] In recent years, attention has also been drawn to the adverse effects on the skin of near-infrared light (near-infrared rays) emitted from the sun and other sources, similar to ultraviolet rays.

[0007] In particular, near-infrared rays have a longer wavelength than ultraviolet rays and have the property of easily reaching deep into the skin, and it has been reported that they can cause wrinkles and sagging of the skin by cutting molecules such as collagen in the subcutaneous tissue.

[0008] Therefore, the present inventors have previously proposed a near-infrared protection agent that does not contain metal oxide as a component that functions against near-infrared rays and that can be used safely on the skin, as well as a method for producing the same (see, for example, Patent Document 1). [Prior art documents] [Patent documents]

[0009] [Patent Document 1] Japanese Patent Application Laid-Open No. 2016-138096 Summary of the Invention [Problem to be solved by the invention]

[0010] However, as far as the present inventors know, there has been no formulation that can exert a protective function against both ultraviolet light and near-infrared light (collectively referred to as dual-range light).

[0011] The present invention has been made in view of the above circumstances, and provides a dual-domain photoprotective formulation capable of exerting a protective function against light in both the ultraviolet and near-infrared regions, and a method for producing the same. [Means for solving the problem]

[0012] In order to solve the above-mentioned problems of the prior art, the dual-domain photoprotective formulation of the present invention comprises (1) a near-infrared protective agent containing an ultraviolet absorber.

[0013] The dual-domain photoprotective formulation of the present invention is also characterized by the following points. (2) The near-infrared protection agent is a mixed emulsion of a second mixed liquid and 10.0 to 25.0 parts by weight of an oil agent, the second mixed liquid being a mixture of a first mixed liquid and 37.0 to 70.8 parts by weight of purified water, and the first mixed liquid is a compound represented by the following general formula (i): [ka] (wherein R1 to R4 are H, a fatty acid, a polyoxyethylene fatty acid, polyoxyethylene, or an alkyl, and at least one of R1 to R4 is a fatty acid, a polyoxyethylene fatty acid, polyoxyethylene, or an alkyl), 15.0 to 20.0 parts by weight of purified water, and a compound represented by the following general formula (ii): [ka] (wherein R' is a polyoxyethylene alkyl represented by (-(EO)n-Alkyl), n is 20 to 30, and the number of carbon atoms in the alkyl group is 14 to 24), and 0.1 to 1.0 part by weight of an acrylic polymer represented by the formula (wherein R' is a polyoxyethylene alkyl represented by (-(EO)n-Alkyl), n is 20 to 30, and the number of carbon atoms in the alkyl group is 14 to 24), and the total proportion of the nonionic surfactant and the acrylic polymer in the near-infrared protective agent is 0.2 to 3.6% by weight. (3) The ultraviolet absorber is selected from the group consisting of homomenthyl salicylate, 2-cyano-3,3-diphenylprop-2-enoic acid 2-ethylhexyl ester (also known as octocrylene), glyceryl di-paramethoxycinnamate mono-2-ethylhexanoate, trisbiphenyltriazine, para-aminobenzoic acid and its esters, 4-tert-butyl-4'-methoxydibenzoylmethane, 4-(2-β-glucopyranosyloxy)propoxy-2-hydroxybenzophenone, octyl salicylate, and methyl 2,5-diisopropylcinnamate. 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoic acid hexyl ester, cinoxate, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone disulfonate sodium, dihydroxybenzophenone, dimethicone diethyl benzalmalonate, 1-(3,4-dimethoxyphenyl)-4,4-dimethyl-1,3-pentanedione, dimethoxybenzylidene dioxoimidazolidinepropionate 2-ethylhexyl, tetrahydroxybenzophenone, terephthalide Dicamphorsulfonic acid, 2,4,6-tris[4-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine, methyl trimethoxycinnamate bis(trimethylsiloxy)silylisopentyl, drometrizole trisiloxane, amyl paradimethylaminobenzoate, 2-ethylhexyl paradimethylaminobenzoate, isopropyl paramethoxycinnamate / diisopropyl cinnamate mixture, 2-ethylhexyl paramethoxycinnamate, 2,4-bis-[{4-(2-ethylhexyloxy)methylisopentyl]aminobenzoate and at least one selected from the group consisting of 2,2'-methylenebis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol, 2-hydroxy-4-methoxybenzophenone, hydroxymethoxybenzophenone sulfonic acid and its trihydrate, sodium hydroxymethoxybenzophenone sulfonate, phenylbenzimidazole sulfonic acid, ferulic acid, and 2,2'-methylenebis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol.

[0014] The present invention also provides a method for producing a dual-domain photoprotective formulation (4) comprising a near-infrared protective agent containing an ultraviolet absorber, wherein the near-infrared protective agent is represented by the following general formula (i): [ka] (wherein R1 to R4 are H, a fatty acid, a polyoxyethylene fatty acid, polyoxyethylene, or an alkyl, and at least one of R1 to R4 is a fatty acid, a polyoxyethylene fatty acid, polyoxyethylene, or an alkyl), 15.0 to 20.0 parts by weight of purified water, and a compound represented by the following general formula (ii): [ka] (wherein R' is a polyoxyethylene alkyl represented by (-(EO)n-Alkyl), n is 20 to 30, and the number of carbon atoms in the alkyl group is 14 to 24), to prepare a first mixed solution; a step of mixing the first mixed solution with 37.0 to 70.8 parts by weight of purified water to prepare a second mixed solution; and a step of mixing the second mixed solution with 10.0 to 25.0 parts by weight of an oil agent to emulsify the mixture, thereby obtaining the near infrared protection agent in which the total ratio of the nonionic surfactant and the acrylic polymer is 0.2 to 3.6% by weight, 2-Ethylhexyl ester (also known as octocrylene), glyceryl di-para-methoxycinnamate mono-2-ethylhexanoate, trisbiphenyl triazine, para-aminobenzoic acid and its esters, 4-tert-butyl-4'-methoxydibenzoylmethane, 4-(2-β-glucopyranosyloxy)propoxy-2-hydroxybenzophenone, octyl salicylate, methyl 2,5-diisopropylcinnamate, 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoic acid hexyl ester, cinoxate, dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenone disulfonate, dihydroxybenzophenone, dimethicone diethyl benzalmalonate, 1-(3,4-dimethoxyphenyl)-4,4-dimethyl-1,3-pentanedione, dimethoxybenzylidene dioxoimidazolidinepropionic acid 2-Ethylhexyl, tetrahydroxybenzophenone, terephthalidene dicamphorsulfonic acid, 2,4,6-tris[4-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine, bis(trimethylsiloxy)silylisopentyl methyl trimethoxycinnamate, drometrizole trisiloxane, amyl paradimethylaminobenzoate, 2-ethylhexyl paradimethylaminobenzoate, isopropyl paramethoxycinnamate / diisopropyl cinnamate mixture, 2-ethylhexyl paramethoxycinnamate, 2,The dual-zone photoprotective formulation contains at least one UV absorber selected from 4-bis-[{4-(2-ethylhexyloxy)-2-hydroxy}-phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine, 2-hydroxy-4-methoxybenzophenone, hydroxymethoxybenzophenone sulfonic acid and its trihydrate, sodium hydroxymethoxybenzophenone sulfonate, phenylbenzimidazole sulfonic acid, ferulic acid, and 2,2'-methylenebis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol in an amount such that the PA (Protection Grade of UVA) of the dual-zone photoprotective formulation is PA+ or higher and / or the SPF (Sun Protection Factor) is 10 or higher. [Effects of the Invention]

[0015] The dual-domain photoprotective formulation and method for producing the same of the present invention can provide a dual-domain photoprotective formulation that can provide protection against light in both the ultraviolet and near-infrared regions, and a method for producing the same. [Brief explanation of the drawings]

[0016] [Figure 1] 1 is a flow diagram illustrating a method for producing a dual-domain photoprotective formulation according to an embodiment of the present invention. [Figure 2] FIG. 10 is an explanatory diagram showing the results of a confirmation test of the near-infrared protection function. DETAILED DESCRIPTION OF THE INVENTION

[0017] The present invention relates to a preparation for protecting the skin from light in a specific wavelength range, and in particular to a dual-range photoprotective preparation capable of exerting protective functions against light in two ranges: ultraviolet light and near-infrared light.

[0018] The dual-domain photoprotective formulation according to this embodiment is characterized by comprising a near-infrared protective agent containing an ultraviolet absorber.

[0019] Here, the near-infrared protection agent is a mixed emulsion of a second mixed liquid of a predetermined composition and 10.0 to 25.0 parts by weight of an oil agent, and is characterized in that the total ratio of the nonionic surfactant and acrylic polymer described below is 0.2 to 3.6% by weight, preferably 0.2 to 3.0% by weight.

[0020] The second mixed liquid is a mixture of the first mixed liquid having a predetermined composition and 37.0 to 70.8 parts by weight of purified water.

[0021] Furthermore, this first mixed liquid is a mixture of 0.1 to 2.0 parts by weight of a nonionic surfactant, 15.0 to 20.0 parts by weight of purified water, and 0.1 to 1.0 part by weight of an acrylic polymer.

[0022] Here, the nonionic surfactant is not particularly limited as long as it is a surfactant that does not exhibit ionic properties when present in an aqueous solvent, i.e., a nonionic surfactant, but it may also have, for example, a sorbitan skeleton in its structure.

[0023] An example of a nonionic surfactant having a sorbitan skeleton is one having the structure shown in the following general formula (i), in which R1 to R4 are either H, a fatty acid, a polyoxyethylene fatty acid, polyoxyethylene, or an alkyl, and at least one of R1 to R4 is either a fatty acid, a polyoxyethylene fatty acid, polyoxyethylene, or an alkyl. [ka]

[0024] By using such a nonionic surfactant, the near-infrared reflective composite can be formed more efficiently.

[0025] The acrylic polymer is not particularly limited as long as it is a polymer of acrylic acid, methacrylic acid, or a derivative thereof. For example, a polymer having the structure shown in (ii) below, in which R is H or a methyl group, and R' is H, an alkyl, or a polyoxyethylene alkyl, can be suitably used. [ka]

[0026] Furthermore, when R' is polyoxyethylene alkyl (-(EO)n-Alkyl), the polymerization number (n) of oxyethylene is not particularly limited, but is preferably 20-30 mer, more preferably 24-26 mer, and even more preferably 25 mer.

[0027] Furthermore, when R' is polyoxyethylene alkyl, the number of carbon atoms in the alkyl is not particularly limited, but for example, those having 12 to 26 carbon atoms, more preferably those having 14 to 24 carbon atoms, even more preferably those having 16 to 24 carbon atoms, and even more preferably those having 18 to 22 carbon atoms can be suitably used.

[0028] UV absorbers include homomenthyl salicylate, 2-cyano-3,3-diphenylprop-2-enoic acid 2-ethylhexyl ester (also known as octocrylene), glyceryl di-paramethoxycinnamate mono-2-ethylhexanoate, trisbiphenyltriazine, para-aminobenzoic acid and its esters, 4-tert-butyl-4'-methoxydibenzoylmethane, 4-(2-β-glucopyranosyloxy)propoxy-2-hydroxybenzophenone, octyl salicylate, methyl 2,5-diisopropylcinnamate, 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoic acid hexyl ester, cinoxate, dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenone disulfonate, and dihydroxybenzophenone. , Dimethicodiethyl Benzalmalonate, 1-(3,4-dimethoxyphenyl)-4,4-dimethyl-1,3-pentanedione, Dimethoxybenzylidene dioxoimidazolidinepropionate 2-ethylhexyl, Tetrahydroxybenzophenone, Terephthalylidene dicamphorsulfonic acid, 2,4,6-tris[4-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine, Methyl trimethoxycinnamate bis(trimethylsiloxy)silylisopentyl, Drometrizole trisiloxane, Amyl paradimethylaminobenzoate, 2-ethylhexyl paradimethylaminobenzoate, Isopropyl paramethoxycinnamate / Diisopropyl cinnamate mixture, Paramethoxycinnamic acid At least one selected from the group consisting of 2-ethylhexyl, 2,4-bis-[{4-(2-ethylhexyloxy)-2-hydroxy}-phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine, 2-hydroxy-4-methoxybenzophenone, hydroxymethoxybenzophenone sulfonic acid and its trihydrate, sodium hydroxymethoxybenzophenone sulfonate, phenylbenzimidazole sulfonic acid, ferulic acid, and 2,2'-methylenebis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol can be used.

[0029] Among these, ethylhexyl methoxycinnamate (2-ethylhexyl paramethoxycinnamate) is a suitable UV-B absorber, and t-butyl methoxydibenzoylmethane (4-tert-butyl-4'-methoxydibenzoylmethane) is a suitable UV-A absorber. The amounts added are preferably such that the dual-zone photoprotective formulation has a UVA (Protection Grade of UVA) of PA+ or higher and / or a Sun Protection Factor (SPF) of 10 or higher.

[0030] The present application also provides a method for producing a dual-domain photoprotective formulation, which is a method for producing a dual-domain photoprotective formulation comprising a near-infrared protective agent containing an ultraviolet absorber, the near-infrared protective agent being prepared through the steps of preparing a predetermined first mixed solution, preparing a predetermined second mixed solution, and forming the mixture into a near-infrared protective agent.

[0031] The step of preparing the predetermined first mixed solution comprises reacting a compound represented by the following general formula (i): [ka] (wherein R1 to R4 are H, a fatty acid, a polyoxyethylene fatty acid, polyoxyethylene, or an alkyl, and at least one of R1 to R4 is a fatty acid, a polyoxyethylene fatty acid, polyoxyethylene, or an alkyl), 15.0 to 20.0 parts by weight of purified water, and a compound represented by the following general formula (ii): [ka] (wherein R' is a polyoxyethylene alkyl represented by (-(EO)n-Alkyl), n is 20 to 30, and the number of carbon atoms in the alkyl group is 14 to 24), and 0.1 to 1.0 parts by weight of an acrylic polymer represented by the formula (-(EO)n-Alkyl),

[0032] The step of preparing the second mixed liquid is a step of preparing the second mixed liquid by mixing the above-mentioned first mixed liquid with 37.0 to 70.8 parts by weight of purified water.

[0033] The step of preparing a near-infrared protection agent is a step of emulsifying the second mixed liquid described above with 10.0 to 25.0 parts by weight of an oil solution to prepare a near-infrared protection agent in which the total ratio of the nonionic surfactant and the acrylic polymer is 0.2 to 3.6% by weight, preferably 0.2 to 3.0% by weight.

[0034] The oil solution preferably contains at least one UV absorber selected from the aforementioned UV absorbers, and the content of the UV absorber in the oil solution is such that the dual-zone photoprotective formulation has a UVA protection grade (PA) of PA+ or higher and / or a sun protection factor (SPF) of 10 or higher.

[0035] The dual-domain photoprotective formulation prepared in this manner may contain auxiliary ingredients other than those mentioned above, provided that the additives do not impair the near-infrared protection function or the ultraviolet protection function. Polyhydric alcohol, thickening polysaccharide Examples include:

[0036] The dual-domain photoprotective formulation and manufacturing method according to this embodiment will be described in further detail below along with the manufacturing process. Here, an example will be described in which the near-infrared protective agent containing an ultraviolet absorber is itself a dual-domain photoprotective formulation, but as described above, the dual-domain photoprotective formulation can contain other auxiliary components in addition to the near-infrared protective agent containing an ultraviolet absorber, within a range in which practical near-infrared protection effect and ultraviolet protection effect can be exhibited.

[0037] 1. Preparation of Dual-Domain Photoprotective Formulations In this section, three dual-domain photoprotective formulations A to C were prepared. The amounts of each component in each formulation are shown in Table 1. [Table 1]

[0038] To prepare each of the dual-domain photoprotective formulations A to C, as shown in the flow chart in Figure 1, first, 0.1 to 2.0 parts by weight of a nonionic surfactant having a sorbitan skeleton was placed in a designated container, followed by 0.1 to 1.0 parts by weight of an acrylic polymer and 15 to 20 parts by weight of purified water, and the mixture was stirred and mixed using a homomixer to prepare a first mixture. This first mixture was then mixed with 37.0 to 70.8 parts by weight (e.g., 66 parts by weight) of purified water to prepare a second mixture.

[0039] Next, 10 to 25 parts by weight of oil is added to this second mixture and emulsified using a homomixer. The oil can be any of the aforementioned UV absorbers, as it has UV-absorbing properties. Here, t-butyl methoxydibenzoylmethane (4-tert-butyl-4'-methoxydibenzoylmethane) as a UVA absorber and ethylhexyl methoxycinnamate (2-ethylhexyl paramethoxycinnamate) as a UVB absorber were used in a weight ratio of 1:10 to 1:20, for example, 1:15.

[0040] In this way, an oil was added to the second mixed solution and emulsified to prepare near-infrared protection agents, which were designated as dual-domain photoprotective formulations A to C according to this embodiment. Dual-domain photoprotective formulation A had a PA+ and an SPF of 10, dual-domain photoprotective formulation B had a PA+++ and an SPF of 30, and dual-domain photoprotective formulation C had a PA++ and an SPF of 20.

[0041] Furthermore, when the total amount of the near-infrared protective agent (two-region photoprotective preparation) is "a parts by weight" and the total amount of the nonionic surfactant having a sorbitan skeleton and the acrylic polymer is "b parts by weight," the composition is prepared so that b / a is in the range of 0.002 to 0.036, preferably in the range of 0.002 to 0.030.

[0042] [2. Confirmation test of near-infrared protection function] Next, among the dual-domain photoprotective formulations A to C described above, dual-domain photoprotective formulation A, which has the smallest amount of near-infrared protective agent components and UV absorber, was subjected to a test to confirm its near-infrared protection function.

[0043] Specifically, vinyl tape was first attached to the surface of a glass plate to set up four test areas measuring 18 mm x 13 mm.

[0044] Next, of these four test sections, the dual-area photoprotective formulation A according to the present embodiment was applied to the first test section, the near-infrared protection agent to the second test section, and a commercially available sunscreen cosmetic to the third test section. The application was carried out by spreading 0.1 g of each sample evenly over each test section using a cotton swab. For comparison, the fourth test section was left untreated.

[0045] Next, the glass plate coated in this manner was fixed with a clamp and placed facing the infrared lamp at a position 180 mm away.

[0046] First, the state of the glass plate before irradiation was photographed with a thermal camera, and then photographs were taken with a thermal camera (G100 manufactured by Nippon Avionics Co., Ltd.) 1, 2, 3, 4, and 5 minutes after the start of irradiation. The results are shown in Figure 2.

[0047] In Figure 2, the dashed lines indicate each divided test area. Also, the higher the brightness (closer to white), the higher the temperature. As shown in Figure 2(a), all test areas were at the same temperature before irradiation, but as shown in Figures 2(b) and 2(c), a rise in temperature was observed across the entire glass plate 1 to 2 minutes after irradiation.

[0048] As shown in Figure 2(d), three minutes after irradiation, the temperatures of test areas 1 and 2, where the sample with near-infrared protection function was applied, remained lower than the temperatures of test areas 3 and 4.

[0049] Then, after 4 to 5 minutes of irradiation, as shown in Figure 2(e) and Figure 2(f), it was found that the overall temperature of the glass plate further increased, but the same temperature trend was maintained.

[0050] These results demonstrate that dual-domain photoprotective formulation A according to the present embodiment, applied to test area 1, has near-infrared protection function substantially equivalent to that of the near-infrared protective agent applied to test area 2. Furthermore, dual-domain photoprotective formulations B and C, which contain even higher amounts of the components of the near-infrared protective agent, were also considered to have near-infrared protection function substantially equivalent to or greater than that of the near-infrared protective agent applied to test area 2.

[0051] Regarding the UV absorbing effect, since it is highly likely that the UV protection effect will be exerted when the UV absorber is contained in the formulation, the description of the experimental results will be omitted in this application.

[0052] As described above, the dual-domain photoprotective formulation and method for producing the same according to this embodiment can provide a dual-domain photoprotective formulation and method for producing the same that can exert protective functions against light in both the ultraviolet and near-infrared regions.

[0053] Finally, the above-described embodiments are merely examples of the present invention, and the present invention is not limited to the above-described embodiments. Therefore, even if the embodiments are different from those described above, various modifications can be made depending on the design, etc., as long as they do not deviate from the technical concept of the present invention.

Claims

1. A dual-domain photoprotective formulation comprising a near-infrared protectant containing an ultraviolet absorber.

2. the near-infrared protection agent is a mixed emulsion of a second mixed liquid and 10.0 to 25.0 parts by weight of an oil agent, the second mixture is a mixture of the first mixture and 37.0 to 70.8 parts by weight of purified water; The first mixed solution is a compound represented by the following general formula (i): 【Chemistry 1】 (However, R1 to R4 are either H, fatty acid, polyoxyethylene fatty acid, polyoxyethylene, or alkyl, and at least one of R1 to R4 is either fatty acid, polyoxyethylene fatty acid, polyoxyethylene, or alkyl.) 0.1 to 2.0 parts by weight of a nonionic surfactant represented by the following general formula (ii): 【Chemistry 2】 (wherein R' is a polyoxyethylene alkyl represented by (-(EO)n-Alkyl), n is 20 to 30, and the alkyl group has 14 to 24 carbon atoms.) and 0.1 to 1.0 parts by weight of an acrylic polymer represented by the formula 2. The dual-domain photoprotective formulation of claim 1, wherein the total weight percent of the nonionic surfactant and the acrylic polymer in the near-infrared protection agent is 0.2 to 3.6% by weight.

3. Examples of the ultraviolet absorber include homomenthyl salicylate, 2-cyano-3,3-diphenylprop-2-enoic acid 2-ethylhexyl ester (also known as octocrylene), glyceryl di-paramethoxycinnamate mono-2-ethylhexanoate, trisbiphenyltriazine, para-aminobenzoic acid and its esters, 4-tert-butyl-4'-methoxydibenzoylmethane, 4-(2-β-glucopyranosyloxy)propoxy-2-hydroxybenzophenone, octyl salicylate, methyl 2,5-diisopropylcinnamate, 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoic acid hexyl ester, cinoxate, dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenone disulfonate, and dihydroxybenzophenone. , Dimethicodiethyl benzalmalonate, 1-(3,4-dimethoxyphenyl)-4,4-dimethyl-1,3-pentanedione, 2-ethylhexyl dimethoxybenzylidene dioxoimidazolidinepropionate, tetrahydroxybenzophenone, terephthalidene dicamphorsulfonic acid, 2,4,6-tris[4-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine, bis(trimethylsiloxy)silylisopentyl methyl trimethoxycinnamate, drometrizole trisiloxane, amyl paradimethylaminobenzoate, 2-ethylhexyl paradimethylaminobenzoate, isopropyl paramethoxycinnamate / diisopropyl cinnamate mixture, paramethoxycinnamic acid 3. The dual-domain photoprotective formulation according to claim 2, wherein the active ingredient is at least one selected from the group consisting of 2-ethylhexyl, 2,4-bis-[{4-(2-ethylhexyloxy)-2-hydroxy}-phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine, 2-hydroxy-4-methoxybenzophenone, hydroxymethoxybenzophenone sulfonic acid and its trihydrate, sodium hydroxymethoxybenzophenone sulfonate, phenylbenzimidazole sulfonic acid, ferulic acid, and 2,2'-methylenebis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol.

4. 1. A method for producing a dual-domain photoprotective formulation comprising a near-infrared protective agent containing an ultraviolet absorber, comprising: The near infrared protection agent is represented by the following general formula (i): 【Transformation 3】 (However, R1 to R4 are either H, fatty acid, polyoxyethylene fatty acid, polyoxyethylene, or alkyl, and at least one of R1 to R4 is either fatty acid, polyoxyethylene fatty acid, polyoxyethylene, or alkyl.) 0.1 to 2.0 parts by weight of a nonionic surfactant represented by the following general formula (ii): 【Chemistry 4】 (wherein R' is a polyoxyethylene alkyl represented by (-(EO)n-Alkyl), n is 20 to 30, and the alkyl group has 14 to 24 carbon atoms.) and 0.1 to 1.0 parts by weight of an acrylic polymer represented by the formula: mixing the first mixture with 37.0 to 70.8 parts by weight of purified water to prepare a second mixture; and a step of mixing and emulsifying the second mixed solution with 10.0 to 25.0 parts by weight of an oil solution to obtain the near-infrared protection agent in which the total ratio of the nonionic surfactant and the acrylic polymer is 0.2 to 3.6% by weight, The oils include homomenthyl salicylate, 2-cyano-3,3-diphenylprop-2-enoic acid 2-ethylhexyl ester (also known as octocrylene), glyceryl di-paramethoxycinnamate mono-2-ethylhexanoate, trisbiphenyltriazine, para-aminobenzoic acid and its esters, 4-tert-butyl-4'-methoxydibenzoylmethane, 4-(2-β-glucopyranosyloxy)propoxy-2-hydroxybenzophenone, octyl salicylate, methyl 2,5-diisopropylcinnamate, 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoic acid hexyl ester, cinoxate, dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenone disulfonate, and dihydroxybenzophenone. , Dimethicodiethyl benzalmalonate, 1-(3,4-dimethoxyphenyl)-4,4-dimethyl-1,3-pentanedione, 2-ethylhexyl dimethoxybenzylidene dioxoimidazolidinepropionate, tetrahydroxybenzophenone, terephthalidene dicamphorsulfonic acid, 2,4,6-tris[4-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine, bis(trimethylsiloxy)silylisopentyl methyl trimethoxycinnamate, drometrizole trisiloxane, amyl paradimethylaminobenzoate, 2-ethylhexyl paradimethylaminobenzoate, isopropyl paramethoxycinnamate / diisopropyl cinnamate mixture, paramethoxycinnamic acid 2-ethylhexyl, 2,4-bis-[{4-(2-ethylhexyloxy)-2-hydroxy}-phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine, 2-hydroxy-4-methoxybenzophenone, hydroxymethoxybenzophenone sulfonic acid and its trihydrate, sodium hydroxymethoxybenzophenone sulfonate, phenylbenzimidazole sulfonic acid, ferulic acid, 2,2'-methylenebis(6-(2H benzotriazol-2-yl)-4-(1,1,3,and (3-tetramethylbutyl)phenol in an amount such that the dual-domain photoprotective formulation has a UVA (Protection Grade of UVA) PA+ or higher and / or a Sun Protection Factor (SPF) of 10 or higher.

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