CDK proteolytic factors, pharmaceutical compositions, and therapeutic applications

Abstract

Provided herein are CDK proteolysis factors, such as compounds of formula (I), and pharmaceutical compositions thereof. Also provided herein is a method of using the same for treating, preventing, or ameliorating one or more symptoms of a CDK-mediated disorder, disease, or condition. 【Chemical 1】 TIFF2025516555001241.tif23170

Claims

1. A compound of formula (I): 【Chemical 1】 or an enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotope variant thereof; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof; (wherein: A is a bond, a heterocyclylene, or -S(O 2 )-; E is a heteroarylene, C 6-14 arylene, or heterocyclylene; L is a linker; X is -C(O)- or a bond; R 1 is (i) hydrogen; (ii) C 1-6 alkyl, C 1-6 heteroalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, C 6-14 aryl, C 7-15 aralkyl, heteroaryl, or heterocyclyl; or (iii) -C(O)R 1a , -C(O)OR 1a , -C(O)NR 1b R 1c , -C(O)SR 1a , -C(NR 1a )NR 1b R 1c , -C(S)R 1a , -C(S)OR 1a , -C(S)NR 1b R 1c , -S(O)R 1a , -S(O) 2 R 1a , -S(O)NR 1b R 1c , or -S(O) 2 NR 1b R 1c ; R 2 、R 3 、and R 4 are each independently (i) hydrogen, deuterium, cyano, halo, or nitro; (ii) C 1-6 alkyl, C 1-6 heteroalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, C 6-14 aryl, C 7-15 aralkyl, heteroaryl, or heterocyclyl; or (iii) -C(O)R 1a , -C(O)OR 1a , -C(O)NR 1b R 1c , -C(O)SR 1a , -C(NR 1a )NR 1b R 1c , -C(S)R 1a , -C(S)OR 1a , -C(S)NR 1b R 1c , -OR 1a , -OC(O)R 1a , -OC(O)OR 1a , -OC(O)NR 1b R 1c , -OC(O)SR 1a , -OC(NR 1a )NR 1b R 1c , -OC(S)R 1a , -OC(S)OR 1a , -OC(S)NR 1b R 1c , -OS(O)R 1a , -OS(O) 2 R 1a , -OS(O)NR 1b R 1c , -OS(O) 2 NR 1b R 1c , -NR 1b R 1c , -NR 1a C(O)R 1d , -NR 1a C(O)OR 1d , -NR 1a C(O)NR 1b R 1c 、 -NR 1a C(O)SR 1d 、 -NR 1a C(NR 1d )NR 1b R 1c 、 -NR 1a C(S)R 1d 、 -NR 1a C(S)OR 1d 、 -NR 1a C(S)NR 1b R 1c 、 -NR 1a S(O)R 1d 、 -NR 1a S(O) 2 R 1d 、 -NR 1a S(O)NR 1b R 1c 、 -NR 1a S(O) 2 NR 1b R 1c 、 -SR 1a 、 -S(O)R 1a 、 -S(O) 2 R 1a 、 -S(O)NR 1b R 1c 、 or -S(O) 2 NR 1b R 1c and; R E is 【Chemical Formula 2】 ; here: Each A E is, independently, a bond, -O-, -N(R 1b ), -, -S-, C 1-6 alkylene, C 1-6 heteroalkylene, C 2-6 alkenylene, C 2-6 heteroalkenylene, C 2-6 alkynylene, C 2-6 heteroalkynylene, C 3-10 cycloalkylene, C 6-14 arylene, C 7-15 aralkylene, heteroarylene, heterocyclylene, C 1-6 heteroalkylene-C 6-14 arylene, C 1-6 heteroalkylene-heterocyclylene, or C 2-6 alkynylene-heterocyclylene; Each X E is, independently, C(R E1 ) or N; Y E is a bond, C 1-6 alkylene, -O-, -S-, -S(O)-, -S(O 2 )-, or -N(R E3 )-; Z is -CH 2 - or -C(O)-; Z 1 、Z 2 、Z 3 、and Z 4 One of them is -C=, and Z 1 、Z 2 、Z 3 、and Z 4 The remaining three of them are each independently -C(R E4a )=; or Z 1 is a bond; Z 2 、Z 3 、and Z 4 One of them is -C=, and Z 2 、Z 3 、and Z 4 The remaining two of them are each independently -C(R E4a )= or -S-; Each R E1 is, independently, hydrogen, deuterium, halo, or C 1-6 alkyl; Each R E2 , R E3 , and R E5 is, independently, hydrogen or C 1-6 alkyl; Each R E4 is, independently, (i) deuterium, cyano, halo, or nitro; (ii) C 1-6 alkyl, C 1-6 heteroalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, C 6-14 aryl, C 7-15 aralkyl, heteroaryl, or heterocyclyl; or (iii) -C(O)R 1a , -C(O)OR 1a , -C(O)NR 1b R 1c , -C(O)SR 1a , -C(NR 1a )NR 1b R 1c , -C(S)R 1a , -C(S)OR 1a , -C(S)NR 1b R 1c , -OR 1a , -OC(O)R 1a , -OC(O)OR 1a , -OC(O)NR 1b R 1c , -OC(O)SR 1a , -OC(NR 1a )NR 1b R 1c , -OC(S)R 1a , -OC(S)OR 1a , -OC(S)NR 1b R 1c , -OS(O)R 1a , -OS(O) 2 R 1a , -OS(O)NR 1b R 1c , -OS(O) 2 NR 1b R 1c , -NR 1b R 1c , -NR 1a C(O)R 1d , -NR 1a C(O)OR 1d , -NR 1a C(O)NR 1b R 1c , -NR 1a C(O)SR 1d 、 -NR 1a C(NR 1d )NR 1b R 1c 、 -NR 1a C(S)R 1d 、 -NR 1a C(S)OR 1d 、 -NR 1a C(S)NR 1b R 1c 、 -NR 1a S(O)R 1d 、 -NR 1a S(O) 2 R 1d 、 -NR 1a S(O)NR 1b R 1c 、 -NR 1a S(O) 2 NR 1b R 1c 、 -SR 1a 、 -S(O)R 1a 、 -S(O) 2 R 1a 、 -S(O)NR 1b R 1c 、 or -S(O) 2 NR 1b R 1c ; and Each R E4a is, independently, hydrogen or R E4 ; each m is independently an integer of 0, 1, or 2; and each n is independently an integer of 0, 1, 2, or 3; and Each R 1a , R 1b , R 1c , and R 1d is, independently, hydrogen, deuterium, C 1-6 alkyl, C 1-6 heteroalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, C 6-14 aryl, C 7-15 aralkyl, heteroaryl, or heterocyclyl; Here, each alkyl, alkylene, heteroalkyl, heteroalkylene, alkenyl, alkenylene, heteroalkenylene, alkynyl, alkynylene, heteroalkynylene, cycloalkyl, cycloalkylene, aryl, arylene, aralkyl, aralkylene, heteroaryl, heteroarylene, heterocyclyl, and heterocyclylene is optionally substituted with one or more, in one embodiment, one, two, three, or four substituents Q, where each Q is (a) deuterium, cyano, halo, imino, nitro, and oxo; (b) each of which is further optionally substituted with one or more, in one embodiment, one, two, three, or four substituents Q a and is further optionally substituted with C 1-6 alkyl, C 1-6 heteroalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, C 6-14 aryl, C 7-15 aralkyl, heteroaryl, and heterocyclyl; and (c) -C(O)R a , -C(O)OR a , -C(O)NR b R c , -C(O)SR a , -C(NR a )NR b R c , -C(S)R a , -C(S)OR a , -C(S)NR b R c , -OR a , -OC(O)R a , -OC(O)OR a , -OC(O)NR b R c , -OC(O)SR a , -OC(NR a )NR b R c , -OC(S)R a , -OC(S)OR a , -OC(S)NR b R c , -OP(O)(OR b )OR c , -OS(O)R a , -OS(O) 2 R a , -OS(O)NR b R c , -OS(O) 2 NR b R c , -NR b R c , -NR a C(O)R d , -NR a C(O)OR d , -NR a C(O)NR b R c , -NR a C(O)SR d , -NR a C(NR d )NR b R c , -NR a C(S)R d , -NR a C(S)OR d , -NR a C(S)NR b R c , -NR a S(O)R d , -NR a S(O) 2 R d , -NR a S(O)NR b R c , -NR a S(O) 2 NR b R c , -SR a , -S(O)R a , -S(O) 2 R a , -S(O)NR b R c , and -S(O) 2 NR b R c (Here, each R a , R b , R c , and R d are independently: (i) hydrogen or deuterium; (ii) each of which is one or more, in one embodiment one, two, three, or four, substituents Q a Optionally substituted with C 1-6 alkyl, C 1-6 heteroalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, C 6-14 aryl, C 7-15 aralkyl, heteroaryl, or heterocyclyl; or (iii) R b and R c together with the N atom to which they are attached form a heterocyclyl optionally substituted with one or more, in one embodiment one, two, three, or four substituents Q a selected independently from: Here, each Q a is (a) deuterium, cyano, halo, nitro, imino, and oxo; (b) C 1-6 alkyl, C 1-6 heteroalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, C 6-14 aryl, C 7-15 aralkyl, heteroaryl, and heterocyclyl; and (c) -C(O)R e , -C(O)OR e , -C(O)NR f R g , -C(O)SR e , -C(NR e )NR f R g , -C(S)R e , -C(S)OR e , -C(S)NR f R g , -OR e , -OC(O)R e , -OC(O)OR e , -OC(O)NR f R g , -OC(O)SR e , -OC(NR e )NR f R g , -OC(S)R e , -OC(S)OR e , -OC(S)NR f R g , -OP(O)(OR f )OR g , -OS(O)R e , -OS(O) 2 R e , -OS(O)NR f R g , -OS(O) 2 NR f R g , -NR f R g , -NR e C(O)R h , -NR e C(O)OR f , -NR e C(O)NR f R g 、 -NR e C(O)SR f 、 -NR e C(NR h )NR f R g 、 -NR e C(S)R h 、 -NR e C(S)OR f 、 -NR e C(S)NR f R g 、 -NR e S(O)R h 、 -NR e S(O) 2 R h 、 -NR e S(O)NR f R g 、 -NR e S(O) 2 NR f R g 、 -SR e 、 -S(O)R e 、 -S(O) 2 R e 、 -S(O)NR f R g 、 and -S(O) 2 NR f R g ; (where each R e 、 R f 、 R g 、 and R h is independently (i) hydrogen or deuterium; (ii) C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, C 6-14 aryl, C 7-15 aralkyl, heteroaryl, or heterocyclyl; or (iii) R f and R g together with the N atom to which they are attached form a heterocyclyl): are independently selected from).

2. C optionally substituted with substituents Q each of which is E and is 1 or more 6-14 The compound according to claim 1, which is an arylene or heteroarylene.

3. The compound according to claim 1 or 2, wherein E is phenyl or monocyclic heteroarylene optionally substituted with one or more substituents Q.

4. A compound according to any one of claims 1 to 3, or an enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotope variant thereof; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof, having the structure of formula (II): [Chemical Formula 3] (wherein: a is an integer of 0, 1, 2, or 3). Y is -C(R 5 )= or -N=; R 5 is hydrogen or R 5a ; Each R 5a is, independently, (i) deuterium, cyano, halo, or nitro; (ii) C 1-6 alkyl, C 1-6 heteroalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, C 6-14 aryl, C 7-15 aralkyl, heteroaryl, or heterocyclyl; or (iii) -C(O)R 1a , -C(O)OR 1a , -C(O)NR 1b R 1c , -C(O)SR 1a , -C(NR 1a )NR 1b R 1c , -C(S)R 1a , -C(S)OR 1a , -C(S)NR 1b R 1c , -OR 1a , -OC(O)R 1a , -OC(O)OR 1a , -OC(O)NR 1b R 1c , -OC(O)SR 1a , -OC(NR 1a )NR 1b R 1c , -OC(S)R 1a , -OC(S)OR 1a , -OC(S)NR 1b R 1c , -OS(O)R 1a , -OS(O) 2 R 1a , -OS(O)NR 1b R 1c , -OS(O) 2 NR 1b R 1c , -NR 1b R 1c , -NR 1a C(O)R 1d , -NR 1a C(O)OR 1d , -NR 1a C(O)NR 1b R 1c , -NR 1a C(O)SR 1d , -NR 1a C(NR 1d )NR 1b R 1c , -NR 1a C(S)R 1d , -NR 1a C(S)OR 1d , -NR 1a C(S)NR 1b R 1c , -NR 1a S(O)R 1d , -NR 1a S(O) 2 R 1d , -NR 1a S(O)NR 1b R 1c , -NR 1a S(O) 2 NR 1b R 1c , -SR 1a , -S(O)R 1a , -S(O) 2 R 1a , -S(O)NR 1b R 1c , or -S(O) 2 NR 1b R 1c ; and

5. The compound according to claim 1, wherein E is heterocyclylene optionally substituted with one or more substituents Q.

6. The compound according to claim 1 or 5, wherein E is monocyclic heterocyclylene optionally substituted with one or more substituents Q.

7. The compound according to claim 1, 5, or 6, wherein E is 6-membered heterocyclylene optionally substituted with one or more substituents Q.

8. The compound according to any one of claims 1 and 5 to 7, wherein E is piperidinediyl optionally substituted with one or more substituents Q.

9. A compound according to any one of claims 1 and 5 to 8, or an enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotope variant thereof; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof, having the structure of formula (IIIB): (wherein: 【Chemical Formula 4】 b is an integer of 0, 1, 2, 3, or 4).

10. Each R 6 is, independently, (i) deuterium, cyano, halo, or nitro; (ii) C 1-6 alkyl, C 1-6 heteroalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, C 6-14 aryl, C 7-15 aralkyl, heteroaryl, or heterocyclyl; or (iii) -C(O)R 1a , -C(O)OR 1a , -C(O)NR 1b R 1c , -C(O)SR 1a , -C(NR 1a )NR 1b R 1c , -C(S)R 1a , -C(S)OR 1a , -C(S)NR 1b R 1c , -OR 1a , -OC(O)R 1a , -OC(O)OR 1a , -OC(O)NR 1b R 1c , -OC(O)SR 1a , OC(NR 1a )NR 1b R 1c , -OC(S)R 1a , -OC(S)OR 1a , -OC(S)NR 1b R 1c , -OS(O)R 1a , -OS(O) 2 R 1a , -OS(O)NR 1b R 1c , -OS(O) 2 NR 1b R 1c , -NR 1b R 1c , -NR 1a C(O)R 1d , -NR 1a C(O)OR 1d , -NR 1a C(O)NR 1b R 1c , -NR 1a C(O)SR 1d , -NR 1a C(NR 1d )NR 1b R 1c , -NR 1a C(S)R 1d , -NR 1a C(S)OR 1d , -NR 1a C(S)NR 1b R 1c , -NR 1a S(O)R 1d , -NR 1a S(O) 2 R 1d , -NR 1a S(O)NR 1b R 1c , -NR 1a S(O) 2 NR 1b R 1c , -SR 1a , -S(O)R 1a , -S(O) 2 R 1a , -S(O)NR 1b R 1c , or -S(O) 2 NR 1b R 1c ; and The compound according to any one of claims 1 to 9, wherein X is a bond.

11. The compound according to any one of claims 1 to 9, wherein X is -C(O)-.

12. ​ ​ The compound according to any one of claims 1 to 11, wherein A is a heterocyclylene optionally substituted by a bond or one or more substituents Q.

13. The compound according to any one of claims 1 to 12, wherein A is a monocyclic heterocyclylene optionally substituted by one or more substituents Q.

14. The compound according to any one of claims 1 to 13, wherein A is a 6-membered heterocyclylene optionally substituted by one, two, or three substituents Q.

15. The compound according to any one of claims 1 to 14, wherein A is piperidine-1,4-diyl or piperazine-1,4-diyl each optionally substituted by one, two, or three substituents Q.

16. The structure of formula (IIA): [Chemical Formula 5] The compound according to any one of claims 4, 10, and 12, having the structure of formula (IIA), or an enantiomer, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotopic variant thereof; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

17. The structure of formula (IIB): 【Chemical Formula 6】 The compound according to any one of claims 4, 11, and 12, having the structure of formula (IIB), or an enantiomer, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotopic variant thereof; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

18. The structure of formula (IIIA): [Chemical Formula 7] The compound according to any one of claims 4, 10, and 12 to 15, having the structure of formula (IIIA), or an enantiomer, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotopic variant thereof; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

19. The structure of formula (IIIB): 【Chemical 8】 The compound according to any one of claims 4 and 11 to 15, having the structure of formula (IIIB), or an enantiomer, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotopic variant thereof; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

20. A is -S(O 2 )- and the compound according to any one of claims 1 to 11.

21. The structure of formula (IIIB): 【Chemical Formula 9】 The compound according to any one of claims 9, 11, and 20 having [specific structure], or an enantiomer thereof, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

22. R E has the structure of formula (EC-I): 【Chemical Formula 10】 The compound according to any one of claims 1 to 21 having [specific structure], or an enantiomer thereof, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant.

23. R E has the structure of formula (EC-I-a): 【Chemical Formula 11】 The compound according to any one of claims 1 to 22 having [specific structure], or an enantiomer thereof, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant.

24. R E has the structure of formula (EC-I-c): 【Chemical 12】 The compound according to any one of claims 1 to 23 having [specific structure], or an enantiomer thereof, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant.

25. R E has the structure of formula (EC-I-d): 【Chemical 13】 The compound according to any one of claims 1 to 23 having [specific structure], or an enantiomer thereof, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant.

26. R E has the structure of formula (EC-I-f): 【Chemical Formula 14】 The compound according to any one of claims 1 to 23 having [specific structure], or an enantiomer thereof, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant.

27. R E has the structure of formula (EC-I-g): 【Chemical Formula 15】 The compound according to any one of claims 1 to 23 having [specific structure], or an enantiomer thereof, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant.

28. R E has the structure of formula (EC-I-h): 【Chemical 16】 The compound according to any one of claims 1 to 22 having [specific structure], or an enantiomer thereof, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant.

29. R E3 The compound according to claim 27, wherein R is hydrogen.

30. R E has the following structure: 【Chemical 17】 A compound according to any one of claims 1 to 23, which has the part; or an enantiomer thereof, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant.

31. R E has the following structure: 【Chemical 18】 A compound according to any one of claims 1 to 23 and 30, which has the part; or an enantiomer thereof, a mixture of enantiomers, a tautomer, a mixture of two or more tautomers, or an isotope variant.

32. R E has the structure of formula (EC-II): 【Chemical Formula 19】 A compound according to any one of claims 1 to 21, which has the part; or an enantiomer thereof, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant.

33. R E has the structure of formula (EC-II-b): 【Chemical 20】 A compound according to any one of claims 1 to 21 and 32, which has the part; or an enantiomer thereof, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant.

34. R E has the structure of formula (EC-II-c): 【Chemical 21】 A compound according to any one of claims 1 to 21 and 32, which has the part; or an enantiomer thereof, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant.

35. R E has the structure of formula (EC-II-e): 【Chemical 22】 A compound according to any one of claims 1 to 21 and 32, which has the part; or an enantiomer thereof, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant.

36. R E has the structure of formula (EC-II-f): 【Chemical 23】 A compound according to any one of claims 1 to 21 and 32, which has the part; or an enantiomer thereof, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant.

37. R E has the following structure: 【Chemical 24】 A compound according to any one of claims 1 to 21 and 32, which has the part; or an enantiomer thereof, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant.

38. R E has the following structure: 【Chemical 25】 【Chem.】 A compound according to any one of claims 1 to 21, 32, and 37, having the part; or an enantiomer, a mixture of enantiomers, a tautomer, a mixture of two or more tautomers, or an isotope variant thereof.

39. R E is of formula (EC-III): 【Chemical 26】 A compound according to any one of claims 1 to 21, having the part; or an enantiomer, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant thereof.

40. R E has the structure of formula (EC-III-c): 【Chemical 27】 A compound according to any one of claims 1 to 21 and 39, having the part; or an enantiomer, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant thereof.

41. R E has the structure of formula (EC-III-d): 【Chemical Formula 28】 A compound according to any one of claims 1 to 21 and 39, having the part; or an enantiomer, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant thereof.

42. R E has the structure of formula (EC-III-e): 【Chemical Formula 29】 A compound according to any one of claims 1 to 21 and 39, having the part; or an enantiomer, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant thereof.

43. R E has the structure of formula (EC-III-h): 【Chemical Formula 30】 A compound according to any one of claims 1 to 21 and 39, having the part; or an enantiomer, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant thereof.

44. R E has the structure of formula (EC-III-i): 【Chemical Formula 31】 A compound according to any one of claims 1 to 21, 39, and 43, having the part; or an enantiomer, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant thereof.

45. R E has the structure of formula (EC-III-k): 【Chemical 32】 A compound according to any one of claims 1 to 21 and 39, having the part; or an enantiomer, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant thereof.

46. R E has the following structure: 【Chemical 33】 The compound according to any one of claims 1 to 21 and 39, which has the part; or its enantiomer, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant.

47. R E has the following structure: 【Chemical 34】 The compound according to any one of claims 1 to 21, 39, and 46, which has the part; or its enantiomer, a mixture of enantiomers, a tautomer, a mixture of two or more tautomers, or an isotope variant.

48. The structure of formula (IVA): 【Chemical 35】 The compound according to claim 4 or 10, which has the part; or its enantiomer, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

49. The structure of formula (VA): 【Chemical 36】 The compound according to any one of claims 4, 10, and 48, which has the part; or its enantiomer, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

50. The structure of formula (VIA): 【Chemical 37】 The compound according to any one of claims 4, 10, and 48, which has the part; or its enantiomer, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

51. The structure of formula (VIIA): 【Chemical Formula 38】 The compound according to any one of claims 4, 10, and 48, which has the part; or its enantiomer, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

52. The structure of formula (VIIIA): 【Chemical 39】 The compound according to any one of claims 4, 10, and 48 having [description of the compound], or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

53. The structure of formula (IXA): 【Chemical 40】 The compound according to claim 4 or 10 having [description of the compound], or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

54. The structure of formula (XA): 【Chemical 41】 The compound according to any one of claims 4, 10, and 53 having [description of the compound], or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

55. The structure of formula (XIA): 【Chemical 42】 The compound according to any one of claims 4, 10, and 53 having [description of the compound], or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

56. The structure of formula (XIIA): 【Chemical 43】 The compound according to any one of claims 4, 10, and 53 having [description of the compound], or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

57. The structure of formula (XIIIA): 【Chemical 44】 The compound according to any one of claims 4, 10, and 53 having [description of the compound], or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

58. The structure of formula (XIVA): 【Chemical 45】 The compound according to claim 4 or 10, or an enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotope variant thereof; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

59. The structure of formula (XVA): 【Chemical Formula 46】 The compound according to any one of claims 4, 10, and 58, or an enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotope variant thereof; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

60. The structure of formula (XVIA): 【Chemical 47】 The compound according to any one of claims 4, 10, and 58, or an enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotope variant thereof; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

61. The structure of formula (XVIIA): 【Chemical 48】 The compound according to any one of claims 4, 10, and 58, or an enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotope variant thereof; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

62. The structure of formula (XVIIIA): 【Chemical 49】 The compound according to any one of claims 4, 10, and 58, or an enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotope variant thereof; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

63. The structure of formula (XIXA): 【Chemical Formula 50】 The compound according to claim 4 or 10, or an enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotope variant thereof; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

64. The structure of formula (XXA): 【Chemical 51】 The compound according to any one of claims 4, 10, and 63 having, or its enantiomer, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

65. The structure of formula (XXIA): 【Chemical 52】 The compound according to any one of claims 4, 10, and 63 having, or its enantiomer, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

66. The structure of formula (XXIIA): 【Chemical 53】 The compound according to any one of claims 4, 10, and 63 having, or its enantiomer, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

67. The structure of formula (XXIIIA): 【Chemical 54】 The compound according to any one of claims 4, 10, and 63 having, or its enantiomer, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

68. The structure of formula (XXVA): 【Chemical Formula 55】 The compound according to claim 4 or 10 having, or its enantiomer, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

69. The structure of formula (XXVIA): 【Chemical 56】 The compound according to claim 4 or 10 having, or its enantiomer, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

70. The structure of formula (XXVIIA): 【Chemical 57】 The compound according to claim 4 or 10, having the following, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

71. The structure of formula (XXIXA): 【Chemical 58】 The compound according to claim 4 or 10, having the following, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

72. The structure of formula (XXXA): 【Chemical Formula 59】 The compound according to claim 4 or 10, having the following, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

73. The structure of formula (XXXIA): 【Chemical Formula 60】 The compound according to claim 4 or 10, having the following, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

74. The structure of formula (IVB): 【Chemical Formula 61】 The compound according to claim 9 or 11, having the following, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

75. The structure of formula (VB): 【Chemical Formula 62】 The compound according to any one of claims 9, 11, and 74, having the following, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

76. The structure of formula (VIB): 【Chemical Formula 63】 The compound according to any one of claims 9, 11, and 74 having the following, or an enantiomer thereof, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

77. The structure of formula (VIIB): 【Chemical Formula 64】 The compound according to any one of claims 9, 11, and 74 having the following, or an enantiomer thereof, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

78. The structure of formula (VIIIB): 【Chemical Formula 65】 The compound according to any one of claims 9, 11, and 74 having the following, or an enantiomer thereof, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

79. The structure of formula (IXB): 【Chemical Formula 66】 The compound according to claim 9 or 11 having the following, or an enantiomer thereof, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

80. The structure of formula (XB): 【Chemical 67】 The compound according to any one of claims 9, 11, and 79 having the following, or an enantiomer thereof, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

81. The structure of formula (XIB): 【Chemical Formula 68】 The compound according to any one of claims 9, 11, and 79 having the following, or an enantiomer thereof, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

82. The structure of formula (XIIB): 【Chemical Formula 69】 The compound according to any one of claims 9, 11, and 79 having the following, or an enantiomer thereof, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

83. The structure of formula (XIIIB): 【Chemical Formula 70】 The compound according to any one of claims 9, 11, and 79 having the following, or an enantiomer thereof, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

84. The structure of formula (XIVB): [Chemical Formula 71] The compound according to claim 9 or 11 having the following, or an enantiomer thereof, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

85. The structure of formula (XVB): 【Chemical Formula 72】 The compound according to any one of claims 9, 11, and 84 having the following, or an enantiomer thereof, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

86. The structure of formula (XVIB): 【Chemical Formula 73】 The compound according to any one of claims 9, 11, and 84 having the following, or an enantiomer thereof, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

87. The structure of formula (XVIIB): 【Chemical Formula 74】 The compound according to any one of claims 9, 11, and 84 having the following, or an enantiomer thereof, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

88. The structure of formula (XVIIIB): 【Chemical 75】 The compound according to any one of claims 9, 11, and 84 having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

89. The structure of formula (XIXB): 【Chemical 76】 The compound according to claim 9 or 11 having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

90. The structure of formula (XXB): 【Chemical Formula 77】 The compound according to any one of claims 9, 11, and 89 having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

91. The structure of formula (XXIB): 【Chemical 78】 The compound according to any one of claims 9, 11, and 89 having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

92. The structure of formula (XXIIB): 【Chemical Formula 79】 The compound according to any one of claims 9, 11, and 89 having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

93. The structure of formula (XXIIIB): 【Chemical Formula 80】 The compound according to any one of claims 9, 11, and 89 having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

94. The structure of formula (XXVB): 【Chemical 81】 The compound according to claim 9 or 11 having the following, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

95. The structure of formula (XXVIB): 【Chemical 82】 The compound according to claim 9 or 11 having the following, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

96. The structure of formula (XXVIIB): 【Chemical 83】 The compound according to claim 9 or 11 having the following, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

97. The structure of formula (XXIXB): 【Chemical 84】 The compound according to claim 9 or 11 having the following, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

98. The structure of formula (XXXB): 【Chemical 85】 The compound according to claim 9 or 11 having the following, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

99. The structure of formula (XXXIB): 【Chemical 86】 The compound according to claim 9 or 11 having the following, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

100. The structure of formula (IIIC): 【Chemical 87】 The compound according to any one of claims 21 having the following, or its enantiomer, a mixture of enantiomers, diastereomer, a mixture of two or more diastereomers, tautomer, a mixture of two or more tautomers, or isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

101. The structure of formula (IVC): 【Chemical 88】 The compound according to any one of claims 21 or 100 having the following, or its enantiomer, a mixture of enantiomers, diastereomer, a mixture of two or more diastereomers, tautomer, a mixture of two or more tautomers, or isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

102. The structure of formula (VC): 【Chemical 89】 The compound according to any one of claims 21 or 100 having the following, or its enantiomer, a mixture of enantiomers, diastereomer, a mixture of two or more diastereomers, tautomer, a mixture of two or more tautomers, or isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

103. The structure of formula (VIC): 【Chemical Formula 90】 The compound according to any one of claims 21 or 100 having the following, or its enantiomer, a mixture of enantiomers, diastereomer, a mixture of two or more diastereomers, tautomer, a mixture of two or more tautomers, or isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

104. The structure of formula (VIIC): 【Chemical Formula 91】 The compound according to any one of claims 21 or 100 having the following, or its enantiomer, a mixture of enantiomers, diastereomer, a mixture of two or more diastereomers, tautomer, a mixture of two or more tautomers, or isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

105. The structure of formula (VIIIC): 【Chemical Formula 92】 The compound according to any one of claims 21 having the following, or its enantiomer, a mixture of enantiomers, diastereomer, a mixture of two or more diastereomers, tautomer, a mixture of two or more tautomers, or isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

106. The structure of formula (IXC): 【Chemical Formula 93】 The compound according to any one of claims 21 or 105 having the following, or its enantiomer, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

107. The structure of formula (XC): 【Chemical Formula 94】 The compound according to any one of claims 21 or 105 having the following, or its enantiomer, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

108. The structure of formula (XIC): 【Chemical Formula 95】 The compound according to any one of claims 21 or 105 having the following, or its enantiomer, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

109. The structure of formula (XIIC): 【Chemical Formula 96】 The compound according to any one of claims 21 or 105 having the following, or its enantiomer, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

110. The structure of formula (XIVC): 【Chemical 97】 The compound according to any one of claims 21 having the following, or its enantiomer, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

111. The structure of formula (XVC): 【Chemical Formula 98】 The compound according to any one of claims 21 having the following, or its enantiomer, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

112. The structure of formula (XIVC): 【Chemical Formula 99】 A compound according to any one of claims 21, or an enantiomer thereof, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotopic variant; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

113. R 1 is C optionally substituted with one or more substituents Q each 1-6 alkyl or C 3-10 cycloalkyl, a compound according to any one of claims 1 to 112.

114. R 1 is a C 3-10 cycloalkyl optionally substituted with one or more substituents Q, the compound according to any one of claims 1 to 113.

115. R 1 is a monocyclic C 3-10 cycloalkyl optionally substituted with one or more substituents Q, the compound according to any one of claims 1 to 114.

116. R 1 The compound according to any one of claims 1 to 115, wherein R is cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl, each optionally substituted with one, two, or three substituents Q.

117. R 1 is cyclopentyl, 2-hydroxy-2-methylcyclopentyl, or 【Chemical 100】 A compound according to any one of claims 1 to 113.

118. R 2 is (i) cyano or halo; (ii) C 1-6 alkyl, C 7-15 aralkyl, or heteroaryl; or (iii) -C(O)R 1a , -C(O)OR 1a , -C(O)NR 1b R 1c , -OR 1a , or -NR 1b R 1c and is a compound according to any one of claims 1 to 117.

119. R 2 is -C(O)R 1a The compound according to any one of claims 1 to 118, wherein

120. R 2 is -C(O)NR 1b R 1c The compound according to any one of claims 1 to 118, wherein

121. R 2 The compound according to any one of claims 1 to 118, wherein R is cyano, fluoro, chloro, bromo, iodo, methyl, ethyl, isopropyl, hydroxymethyl, ethoxymethyl, benzyl, oxazol-5-yl, acetyl, hydroxycarbonyl, ethoxycarbonyl, methylaminocarbonyl, dimethylaminocarbonyl, 2-ethoxy-ethoxy, or amino.

122. R 2 The compound according to any one of claims 1 to 118, wherein R is difluoromethyl, acetyl, or dimethylaminocarbonyl.

123. R 3 is C optionally substituted with hydrogen, deuterium, or one or more substituents Q 1-6 alkyl, a compound according to any one of claims 1 to 122.

124. R 3 The compound according to any one of claims 1 to 123, wherein R is hydrogen, deuterium, or methyl.

125. R 3 The compound according to any one of claims 1 to 124, wherein R is hydrogen.

126. R 3 The compound according to any one of claims 1 to 124, wherein R is methyl.

127. R 4 The compound according to any one of claims 1 to 126, wherein R is hydrogen.

128. Y is -C(R 5 )=, a compound according to any one of claims 1 to 127.

129. R 5 is C optionally substituted with hydrogen, deuterium, halo, or one or more substituents Q 1-6 alkyl, a compound according to any one of claims 1 to 128.

130. R 5 The compound according to any one of claims 1 to 129, wherein R is hydrogen, fluoro, chloro, methyl, or ethyl.

131. R 5 The compound according to any one of claims 1 to 130, wherein R is hydrogen.

132. A compound according to any one of claims 1 to 131, wherein Y is -N=.

133. A compound according to any one of claims 1 to 132, wherein a is an integer of 1.

134. R 5a is C optionally substituted with deuterium, halo, or one or more substituents Q 1-6 alkyl, a compound according to any one of claims 1 to 133.

135. R 5a The compound according to any one of claims 1 to 134, wherein R is hydrogen, fluoro, chloro, methyl, or ethyl.

136. A compound according to any one of claims 1 to 135, wherein a is an integer of 0.

137. R E1 The compound according to any one of claims 1 to 136, wherein R is hydrogen.

138. R E2 The compound according to any one of claims 1 to 137, wherein R is hydrogen.

139. A compound according to any one of claims 1 to 138, wherein n is an integer of 1 or 2.

140. Each R E4 is, independently, deuterium, halo, or C optionally substituted with one or more substituents Q 1-6 alkyl, a compound according to any one of claims 1 to 139.

141. Each R E4 is independently fluoro, chloro, methyl, isopropyl, or trifluoromethyl, a compound according to any one of claims 1 to 140.

142. R E4 The compound according to any one of claims 1 to 141, wherein R is methyl or trifluoromethyl.

143. A compound according to any one of claims 1 to 142, wherein n is an integer of 0.

144. R E4a The compound according to any one of claims 1 to 143, wherein R is hydrogen, deuterium, or a halogen.

145. R E4a The compound according to any one of claims 1 to 144, wherein R is hydrogen, deuterium, fluoro, or chloro.

146. R E4a The compound according to any one of claims 1 to 145, wherein R is fluoro.

147. R E5 is C optionally substituted with hydrogen or one or more substituents Q 1-6 alkyl, a compound according to any one of claims 1 to 146.

148. R E5 The compound according to any one of claims 1 to 147, wherein R is hydrogen or methyl.

149. R E5 The compound according to any one of claims 1 to 148, wherein R is methyl.

150. A E is (i) a bond; or (ii) C, each of which is optionally substituted with one or more substituents Q 2-6 alkynylene, heterocyclylene, C 1-6 heteroalkylene-C 6-14 arylene, C 1-6 alkylene-heterocyclylene, or C 2-6 alkynylene-heterocyclylene, and the compound according to any one of claims 1 to 149

151. A E is a heterocyclylene, C 1-6 heteroalkylene-C 6-14 arylene, or C 1-6 alkylene-heterocyclylene, which is bonded; or (ii) each of which is optionally substituted with one or more substituents Q, and is a compound according to any one of claims 1 to 150.

152. A E is a heterocyclylene, C 1-6 heteroalkylene-C 6-14 arylene, or C 1-6 alkylene-monocyclic heterocyclylene, which is either (i) unsubstituted or (ii) each optionally substituted with one or more substituents Q, the compound according to any one of claims 1 to 151.

153. A E is a heterocyclylene, C 1-6 heteroalkylene-phenylene, or C 1-6 alkylene-(6-membered heterocyclylene), which is (i) linked; or (ii) each of which is optionally substituted with one or more substituents Q, and is a compound according to any one of claims 1 to 152.

154. A E is coupling, piperidine-1,3-diyl, piperidine-1,4-diyl, piperazine-1,4-diyl, (phen-1,4-diyl)oxymethanediyl, (piperidine-1,4-diyl)ethynediyl, 【Chemical 101】 A compound according to any one of claims 1 to 153.

155. A E is combined with, 【Chemical 102】 A compound according to any one of claims 1 to 154.

156. A compound according to any one of claims 1 to 155, wherein L has the following structure: 【Chemical 103】 (wherein: z is an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10). Each R L is, independently, C 1-10 alkylene, C 2-10 alkenylene, C 2-10 alkynylene, C 3-10 cycloalkylene, C 6-14 arylene, heteroarylene, or heterocyclylene, each optionally substituted with one or more substituents Q; each Z L is independently a bond, -C(O)-, -C(O)O-, -C(O)NR 1b -, -C(O)S-, -C(NR 1a )NR 1b -, -C(S)-, -C(S)O-, -C(S)NR 1b -, -O-, -OC(O)O-, -OC(O)NR 1b -, -OC(O)S-, -OC(NR 1a )NR 1b -, -OC(S)-, -OC(S)O-, -OC(S)NR 1b -, -OS(O)-, -OS(O) 2 -, -OS(O)NR 1b -, -OS(O) 2 NR 1b -, -NR 1b -, -NR 1a C(O)NR 1b -, -NR 1a C(O)S-, -NR 1a C(NR 1d )NR 1b -, -NR 1a C(S)NR 1b -, -NR 1a S(O)NR 1b -, -NR 1a S(O) 2 NR 1b -, -S-, -S(O)-, -S(O) 2 -, -S(O)NR 1b -, or -S(O) 2 NR 1b -; and

157.

158. Each R L is, independently, C which is optionally substituted with one or more substituents Q 1-10 alkylene, C 2-10 alkynylene, C 3-10 cycloalkylene, C 6-14 arylene, heteroarylene, or heterocyclylene, and the compound according to claim 156

159. each R L is, independently, methylene, ethane-1,2-diyl, propane-1,3-diyl, butane-1,4-diyl, pentane-1,5-diyl, hexane-1,6-diyl, heptane-1,7-diyl, octane-1,8-diyl, nonane-1,9-diyl, decane-1,10-diyl, undecane-1,11-diyl, dodecane-1,12-diyl, tridecane-1,13-diyl, ethyne-1,2-diyl, cyclobutane-1,3-diyl, cyclopentane-1,3-diyl, cyclohexane-1,3-diyl, cyclohexane-1,4-diyl, cycloheptane-1,3-diyl, cycloheptane-1,4-diyl, bicyclo[2.2.2]octane-1,4-diyl, phen-1,3-diyl, phen-1,4-diyl, pyrazole-1,3-diyl, pyrazole-1,4-diyl, imidazole-1,4-diyl, 1,2,3-triazole-1,4-diyl, pyrimidine-2,4-diyl, pyrimidine-2,5-diyl, 5,6,7,8,9,10-hexahydrocycloocta[d]pyridazine-1,7-diyl, pyrazolidine-1,3-diyl, pyrazolidine-1,4-diyl, 1,3-dioxane-2,5-diyl, piperazine-1,4-diyl, piperidine-1,3-diyl, piperidine-1,4-diyl, or 3,9-diazaspiro[5.5]undecane-3,9-diyl, each optionally substituted with one or more substituents Q, the compound according to claim 156 or 157.

160. each Z L is, independently, a bond, -C(O)-, -C(O)NR 1b -, -O-, -OC(O)NR 1b -, -NR 1b -, or -NR 1a C(O)NR 1b -, a compound according to any one of claims 156 to 158.

161. each Z L is independently a bond, -C(O)-, -C(O)O-, -C(O)NH-, -OC(O)NH-, -O-, -NH-, -N(CH 3 )-, or -NHC(O)NH-, a compound according to any one of claims 156 to 159. A compound according to any one of claims 156 to 160, wherein z is an integer of 1, 2, 3, or 4.

162.

163. each R L is, independently, each optionally substituted with one, two, or three substituents, each of which is independently fluoro or methyl, of methanediyl, ethane-1,2-diyl, propane-1,3-diyl, cyclohexane-1,3-diyl, cyclohexane-1,4-diyl, phen-1,3-diyl, phen-1,4-diyl, azetidine-1,3-diyl, piperazine-1,4-diyl, piperidine-1,3-diyl, piperidine-1,4-diyl, morpholine-2,4-diyl, 4,7-diazaspiro[2.5]octane-4,7-diyl, 3-azabicyclo[3.2.1]octane-3,8-diyl, 8-azabicyclo[3.2.1]-octane-3,8-diyl, 3,8-diazabicyclo[3.2.1]octane-3,8-diyl, or 2,7-diazaspiro[3.5]nonane-2,7-diyl; each Z L is, independently, a bond or -O-; and z is an integer of 2, 3, 4, or 5, the compound according to claim 156.

164. Each R L is, independently, methylene, ethane-1,2-diyl, 1,1-difluoroethane-1,2-diyl, propane-1,3-diyl, cyclohexane-1,3-diyl, cyclohexane-1,4-diyl, phen-1,3-diyl, phen-1,4-diyl, azetidine-1,3-diyl, 3-fluoroazetidine-1,3-diyl, piperazine-1,4-diyl, 2-methylpiperazine-1,4-diyl, piperidine-1,3-diyl, piperidine-1,4-diyl, 4-fluoro-piperidine-1,4-diyl, morpholine-2,4-diyl, 4,7-diazaspiro[2.5]octane-4,7-diyl, 3-azabicyclo[3.2.1]-octane-3,8-diyl, 8-azabicyclo[3.2.1]octane-3,8-diyl, 3,8-diazabicyclo[3.2.1]octane-3,8-diyl, or 2,7-diazaspiro[3.5]nonane-2,7-diyl; each Z L is, independently, a bond or -O-; and z is an integer of 2, 3, 4, or 5, the compound according to claim 156 or 162. A compound according to any one of claims 1 to 156, wherein L is 【Chemical 104】

165. A compound according to any one of claims 1 to 156, wherein L is 【Chemical 105】 【Chem.】

166. A compound according to any one of claims 1 to 156, wherein L is ​ 【Chemical 106】 [Chemical] 【Chem.】 【Chem.】 【Chem.】 The compound according to any one of claims 1 to 156.

167. Z is -CH 2 - and is a compound according to any one of claims 1 to 166.

168. The compound according to any one of claims 1 to 167, wherein m is an integer of 1.

169. 7-Cyclopentyl-2-((4-((2-(4-(2-(3-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)-piperazin-1-yl)ethyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A101; 7-Cyclopentyl-2-((4-((4-(4-(2-(3-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)-piperazin-1-yl)butyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A102; 7-Cyclopentyl-2-((4-((6-(4-(2-(3-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)-piperazin-1-yl)hexyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A103; 7-Cyclopentyl-2-((4-(4-(2-(4-(2-(3-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)-piperazin-1-yl)ethyl)piperazin-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A104; 7-Cyclopentyl-2-((4-(4-(4-(4-(2-(3-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)-piperazin-1-yl)butyl)piperazin-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A105; 7-Cyclopentyl-2-((4-(4-(2-(1-(2-(3-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)-piperidin-4-yl)ethyl)piperazin-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A106; 7-Cyclopentyl-2-((4-(4-(4-(1-(2-(3-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)piperidin-4-yl)butyl)piperazin-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A107; 7-Cyclopentyl-2-((4-(4-(2-(2-(3-(2,6-dioxopiperidin-3-yl)phenoxy)acetamido)-ethyl)piperazin-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A108; 7-Cyclopentyl-2-((4-(4-(2-(2-(3-(2,6-dioxopiperidin-3-yl)-4-methylphenoxy)-acetamido)ethyl)piperazin-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A109; 7-Cyclopentyl-2-((4-(4-(2-(2-(3-(2,6-dioxopiperidin-3-yl)-4-(trifluoromethyl)-phenoxy)acetamido)ethyl)piperazin-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A110; 7-Cyclopentyl-2-((4-(4-(3-(2-(3-(2,6-dioxopiperidin-3-yl)phenoxy)acetamido)-propyl)piperazin-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A111; 7-Cyclopentyl-2-((4-(4-(3-(2-(3-(2,6-dioxopiperidin-3-yl)-4-methylphenoxy)-acetamido)propyl)piperazin-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A112; 7-Cyclopentyl-2-((4-(4-(3-(2-(3-(2,6-dioxopiperidin-3-yl)-4-(trifluoromethyl)-phenoxy)acetamido)propyl)piperazin-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A113; 7-Cyclopentyl-2-((4-((2-(4-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)-piperazin-1-yl)ethyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A114; 7-Cyclopentyl-2-((4-((4-(4-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)-piperazin-1-yl)butyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A115; 7-Cyclopentyl-2-((4-((6-(4-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetyl)-piperazin-1-yl)hexyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A116; 7-Cyclopentyl-2-((4-(4-(3-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)-phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A117; 7-Cyclopentyl-2-((4-(4-(4-(2,6-dioxopiperidin-3-yl)benzyl)piperazin-1-yl)-phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A118; 7-Cyclopentyl-2-((4-(4-(4-(2,6-dioxopiperidin-3-yl)phenethyl)piperazin-1-yl)-phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A119; 7-Cyclopentyl-2-((4-(4-(3-(2,6-dioxopiperidin-3-yl)phenethyl)piperazin-1-yl)-phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A120; 7-Cyclopentyl-2-((4-(4-(2-(3-(2,6-dioxopiperidin-3-yl)phenoxy)ethyl)piperazin-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A121; 7-Cyclopentyl-2-((4-(2-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)ethyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A122; 7-Cyclopentyl-2-((4-(2-(4-(3-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)ethyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A123; 7-Cyclopentyl-2-((4-(2-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)ethoxy)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A124; 7-Cyclopentyl-2-((4-(2-(4-(3-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)ethoxy)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A125; 7-Cyclopentyl-2-((4-(4-(1-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)piperazin-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A126; 7-Cyclopentyl-2-((4-(4-(1-(3-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)piperazin-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A127; 7-Cyclopentyl-2-((4-(2-(4-(4-(2,6-dioxopiperidin-3-yl)benzyl)piperazin-1-yl)ethyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A128; 7-Cyclopentyl-2-((4-(2-(4-(3-(2,6-dioxopiperidin-3-yl)benzyl)piperazin-1-yl)ethyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A129; 7-Cyclopentyl-2-((4-(2-(4-(4-(2,6-dioxopiperidin-3-yl)benzyl)piperazin-1-yl)-ethoxy)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A130; 7-Cyclopentyl-2-((4-(2-(4-(3-(2,6-dioxopiperidin-3-yl)benzyl)piperazin-1-yl)-ethoxy)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A131; 7-Cyclopentyl-2-((4-((4-(1-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)-piperazin-1-yl)methyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A132; 7-Cyclopentyl-2-((4-(2-(4-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)-piperidin-1-yl)ethoxy)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A133; 7-Cyclopentyl-2-((4-(2-(4-(4-(3-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)-piperidin-1-yl)ethoxy)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A134; 7-Cyclopentyl-2-((4-(2-(4-(1-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)piperazin-1-yl)ethyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A135; 7-Cyclopentyl-2-((4-(2-(4-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)-piperidin-1-yl)ethyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A136; 7-Cyclopentyl-2-((4-(2-(4-(4-(3-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)piperidin-1-yl)ethyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A137; 7-Cyclopentyl-2-((4-(4-(1-(4-(2,6-dioxopiperidin-3-yl)benzyl)piperidin-4-yl)piperazin-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A138; 7-Cyclopentyl-2-((4-(4-(1-(4-(2,6-dioxopiperidin-3-yl)phenethyl)piperidin-4-yl)piperazin-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A139; 7-Cyclopentyl-2-((4-(4-(1-(3-(2,6-dioxopiperidin-3-yl)phenethyl)piperidin-4-yl)piperazin-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A140; 7-Cyclopentyl-2-((4-(4-((1-(3-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A141; 7-Cyclopentyl-2-((4-(4-((1-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A142; 7-Cyclopentyl-2-((4-(4-(2-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-1-yl)ethyl)piperazin-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A143; 7-Cyclopentyl-2-((4-(4-(2-(4-(3-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-1-yl)ethyl)piperazin-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A144; 7-Cyclopentyl-2-((5-(4-(3-(4-(4-(2,6-dioxopiperidin-3-yl)benzyl)piperazin-1-yl)phenyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A145; 7-Cyclopentyl-2-((5-(4-(3-(4-(4-(2,6-dioxopiperidin-3-yl)phenethyl)piperazin-1-yl)phenyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A146; 7-Cyclopentyl-2-((5-(4-(3-(4-(3-(2,6-dioxopiperidin-3-yl)phenethyl)piperazin-1-yl)phenyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A147; 7-Cyclopentyl-2-((5-(4-(4-(4-(4-(2,6-dioxopiperidin-3-yl)benzyl)piperazin-1-yl)phenyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A148; 7-Cyclopentyl-2-((5-(4-(4-(4-(4-(2,6-dioxopiperidin-3-yl)phenethyl)piperazin-1-yl)phenyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A149; 7-Cyclopentyl-2-((5-(4-(4-(4-(3-(2,6-dioxopiperidin-3-yl)phenethyl)piperazin-1-yl)phenyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A150; 7-Cyclopentyl-2-((5-(4-(4-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)-benzyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A151; 7-Cyclopentyl-2-((5-(4-(4-((4-(3-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)-methyl)phenyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A152; 7-Cyclopentyl-2-((5-(4-(4-(4-(3-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)-benzyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A153; 7-Cyclopentyl-2-((5-(4-(4-((4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)-methyl)phenyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A154; 7-Cyclopentyl-2-((5-(4-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)phenethyl)cyclohexyl)-piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A155; 7-Cyclopentyl-2-((5-(4-(1-(4-(2,6-dioxopiperidin-3-yl)phenyl)phenethyl)piperidin-4-yl)-piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A156; 7-Cyclopentyl-2-((5-(4-(1-(2-(4-(2,6-dioxopiperidin-3-yl)phenyl)phenoxy)ethyl)-piperidin-4-yl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A157; 7-Cyclopentyl-2-((5-(4-(1-((1-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)-methyl)piperidin-4-yl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A158; 7-Cyclopentyl-2-((5-(4-((1'-(4-(2,6-dioxopiperidin-3-yl)phenyl)-[1,4'-bipiperidin]-4-yl)methyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A159; 7-Cyclopentyl-2-((5-(4-(1-(2-(3-(2,6-dioxopiperidin-3-yl)phenoxy)ethyl)-piperidin-4-yl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A160; 7-Cyclopentyl-2-((5-(4-(3-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)propyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A161; 7-Cyclopentyl-2-((5-(4-(1'-(4-(2,6-dioxopiperidin-3-yl)phenyl)-[1,4'-bipiperidin]-3-yl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A162; 7-Cyclopentyl-2-((5-(4-(1-((1-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)methyl)piperidin-3-yl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A163; 7-Cyclopentyl-2-((5-(4-(1-(((2S)-4-(4-(2,6-dioxopiperidin-3-yl)phenyl)-morpholin-2-yl)methyl)piperidin-4-yl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A164; 7-Cyclopentyl-2-((5-(4-(1-(((2R)-4-(4-(2,6-dioxopiperidin-3-yl)phenyl)-morpholin-2-yl)methyl)piperidin-4-yl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A165; 7-Cyclopentyl-2-((5-(4-(3-(1-(4-(2,6-dioxopiperidin-3-yl)benzyl)piperidin-4-yl)-cyclohexyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A166; 7-Cyclopentyl-2-((5-(4-(1-((1-(4-(2,6-dioxopiperidin-3-yl)phenyl)azetidin-3-yl)-methyl)piperidin-4-yl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A167; 7-Cyclopentyl-2-((5-(4-(((2S)-4-(1-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)morpholin-2-yl)methyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A168; 7-Cyclopentyl-2-((5-(4-(((2R)-4-(1-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)morpholin-2-yl)methyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A169; 7-Cyclopentyl-2-((5-(4-((4-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)cyclohexyl)methyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A170; 7-Cyclopentyl-2-((5-(4-(2-(4-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)cyclohexyl)ethyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A171; 7-Cyclopentyl-2-((5-(4-(1-(2-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)ethyl)piperidin-4-yl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A172; 7-Cyclopentyl-2-((5-(4-(4-(2-(1-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)ethyl)cyclohexyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A173; 7-Cyclopentyl-2-((5-(4-(1-(2-(1-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)ethyl)piperidin-4-yl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A174; 7-Cyclopentyl-2-((5-(4-(2-(1'-(4-(2,6-dioxopiperidin-3-yl)phenyl)-[4,4'-bipiperidin]-1-yl)ethyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A175; 7-Cyclopentyl-2-((5-(4-(2-(1'-(4-(2,6-dioxopiperidin-3-yl)phenyl)-[1,4'-bipiperidin]-4-yl)ethyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A176; 7-Cyclopentyl-2-((5-(4-(2-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)-ethyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A177; 7-Cyclopentyl-2-((5-(4-(2-(1-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)-ethyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A178; 7-Cyclopentyl-2-((5-(4-(1-(3-(4-(2,6-dioxopiperidin-3-yl)phenoxy)propyl)-piperidin-4-yl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A179; 7-Cyclopentyl-2-((5-(4-(3-(1-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)-propyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A180; 7-Cyclopentyl-2-((5-(4-(4-(1-(4-(2,6-dioxopiperidin-3-yl)phenyl)phenethyl)piperidin-4-yl)cyclohexyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A181; 7-Cyclopentyl-2-((5-(4-(4-(2,6-dioxopiperidin-3-yl)phenethyl)-[1,4'-bipiperidin]-1'-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A182; 7-Cyclopentyl-2-((5-((1'-(4-(2,6-dioxopiperidin-3-yl)phenyl)-[1,4'-bipiperidin]-4-yl)methyl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A183; 7-Cyclopentyl-2-((5-((1'-(4-(2,6-dioxopiperidin-3-yl)phenyl)-[4,4'-bipiperidin]-1-yl)methyl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A184; 7-Cyclopentyl-2-((5-((4-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)-piperidin-1-yl)methyl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A185; 7-Cyclopentyl-2-((5-((1'-(4-(2,6-dioxopiperidin-3-yl)phenyl)-[1,4'-bipiperidin]-4-yl)oxy)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A186; 7-Cyclopentyl-2-((5-((1'-(4-(2,6-dioxopiperidin-3-yl)phenyl)-[1,4'-bipiperidin]-4-yl)methoxy)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A187; 7-Cyclopentyl-2-((5-(2-(1'-(4-(2,6-dioxopiperidin-3-yl)phenyl)-[4,4'-bipiperidin]-1-yl)ethyl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A188; 7-Cyclopentyl-2-((5-(2-(1'-(4-(2,6-dioxopiperidin-3-yl)phenyl)-[1,4'-bipiperidin]-4-yl)ethyl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A189; 7-Cyclopentyl-2-((5-(2-(4-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)piperidin-1-yl)ethyl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A190; 7-Cyclopentyl-2-((5-(2-(1'-(4-(2,6-dioxopiperidin-3-yl)phenyl)-[4,4'-bipiperidin]-1-yl)ethoxy)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A191; 7-Cyclopentyl-2-((5-(2-(1'-(4-(2,6-dioxopiperidin-3-yl)phenyl)-[1,4'-bipiperidin]-4-yl)ethoxy)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A192; 7-Cyclopentyl-2-((5-(2-(4-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)piperidin-1-yl)ethoxy)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A193; 7-Cyclopentyl-2-((5-(4-(1-((1-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)-methyl)azetidin-3-yl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A194; 7-Cyclopentyl-2-((5-(4-(1'-(4-(2,6-dioxopiperidin-3-yl)phenyl)-[1,4'-bipiperidin]-4-yl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A195; 7-Cyclopentyl-2-((5-(4-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)-[1,4'-bipiperidin]-1'-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A196; 7-Cyclopentyl-2-((5-(4-(4-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)-cyclohexyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A197; 7-Cyclopentyl-2-((5-(4-(4-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)-cyclohexyl)piperidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A198; 7-Cyclopentyl-2-((5-(4-(1-(3-(3-(2,6-dioxopiperidin-3-yl)phenoxy)propyl)-piperidin-4-yl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-arbxamide A199; 7-Cyclopentyl-2-((5-((4-(1-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)-piperazin-1-yl)methyl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A200; 7-Cyclopentyl-2-((5-(2-(4-(1-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)-piperazin-1-yl)ethyl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A201; 7-Cyclopentyl-2-((5-(3-(1'-(4-(2,6-dioxopiperidin-3-yl)phenyl)-[4,4'-bipiperidin]-1-yl)propyl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A202; 7-Cyclopentyl-2-((5-(3-(4-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)-piperidin-1-yl)propyl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A203; 7-Cyclopentyl-2-((5-(3-(4-(1-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)piperazin-1-yl)propyl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A204; 7-Cyclopentyl-2-((5-(3-(1'-(4-(2,6-dioxopiperidin-3-yl)phenyl)-[1,4'-bipiperidin]-4-yl)propyl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A205; 7-Cyclopentyl-2-((5-(2-(4-(4-(3-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)piperidin-1-yl)ethyl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A206; 7-Cyclopentyl-2-((5-((2S)-2-((4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)methyl)morpholino)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A207; 7-Cyclopentyl-2-((5-((2R)-2-((4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)methyl)morpholino)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A208; 7-Cyclopentyl-2-((5-(4-(4-(4-(2,6-dioxopiperidin-3-yl)phenethyl)piperazin-1-yl)piperidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A209; 7-Cyclopentyl-2-((5-((1'-(4-(2,6-dioxopiperidin-3-yl)phenyl)-[1,4'-bipiperidin]-3-yl)oxy)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A210; 7-Cyclopentyl-2-((5-((3-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)piperidin-1-yl)methyl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A211; 7-Cyclopentyl-2-((5-((1'-(4-(2,6-dioxopiperidin-3-yl)phenyl)-[3,4'-bipiperidin]-1-yl)methyl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A212; 7-Cyclopentyl-2-((5-(2-(3-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)piperidin-1-yl)ethoxy)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A213; 7-Cyclopentyl-2-((5-(4-((4-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)piperidin-1-yl)methyl)piperidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A214; 7-Cyclopentyl-2-((5-(4-(4-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-1-yl)benzyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A215; 7-Cyclopentyl-2-((5-(4-(4-((4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-1-yl)methyl)phenyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A216; 7-Cyclopentyl-2-((5-(4-((1-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)methyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A217; 7-Cyclopentyl-2-((5-(1-((1-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)-methyl)piperidin-4-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A218; 7-Cyclopentyl-2-((5-(4-((4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)-methyl)piperidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A219; 7-Cyclopentyl-2-((5-(4-((4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-1-yl)-methyl)piperidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A220; 7-Cyclopentyl-2-((5-(4-((1-(3-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)-methyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A221; 7-Cyclopentyl-2-((5-(1-((1-(3-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)-methyl)piperidin-4-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A222; 7-Cyclopentyl-2-((5-(4-((4-(3-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)-methyl)piperidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A223; 7-Cyclopentyl-2-((5-(4-((4-(3-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-1-yl)-methyl)piperidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A224; 7-Cyclopentyl-2-((5-((4-(4-(2,6-dioxopiperidin-3-yl)phenyl)-[1,4'-bipiperidin]-1'-yl)methyl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A225; 7-Cyclopentyl-2-((5-(4-(2-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-1-yl)-ethyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A226; 7-Cyclopentyl-2-((5-(1-(2-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-1-yl)-ethyl)piperidin-4-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A227; 7-Cyclopentyl-2-((5-(1-(2-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)-ethyl)piperidin-4-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A228; 7-Cyclopentyl-2-((5-(1-(2-(4-(3-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)-ethyl)piperidin-4-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A229; 7-Cyclopentyl-2-((5-(4-(2-(4-(3-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-1-yl)-ethyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A230; 7-Cyclopentyl-2-((5-(4-(2-(1-(3-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)-ethyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A231; 7-Cyclopentyl-2-((5-(4-(2-(4-(3-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)ethyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A232; 7-Cyclopentyl-2-((5-(1-(2-(4-(3-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)ethyl)piperidin-4-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A233; 7-Cyclopentyl-2-((5-(1-(2-(1-(3-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)ethyl)piperidin-4-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A234; 7-Cyclopentyl-2-((5-(1-(2-(4-(3-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)ethyl)piperidin-4-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A235; 7-Cyclopentyl-2-((5-(2-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)-[1,4'-bipiperidin]-1'-yl)ethyl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A236; 7-Cyclopentyl-2-((5-(1'-(4-(2,6-dioxopiperidin-3-yl)phenethyl)-[4,4'-bipiperidin]-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A237; 7-Cyclopentyl-2-((5-(1'-(4-(2,6-dioxopiperidin-3-yl)phenethyl)-[1,4'-bipiperidin]-4-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A238; 7-Cyclopentyl-2-((5-(2-(4-(1-(3-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)-piperazin-1-yl)ethyl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A239; 7-Cyclopentyl-2-((5-(2-(1'-(3-(2,6-dioxopiperidin-3-yl)phenyl)-[1,4'-bipiperidin]-4-yl)ethyl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A240; 7-Cyclopentyl-2-((5-(2-(1'-(3-(2,6-dioxopiperidin-3-yl)phenyl)-[4,4'-bipiperidin]-1-yl)ethyl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A241; 7-Cyclopentyl-2-((5-(2-(4-(3-(2,6-dioxopiperidin-3-yl)phenyl)-[1,4'-bipiperidin]-1'-yl)ethyl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A242; 7-Cyclopentyl-2-((5-(2-(4-(1-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)-piperazin-1-yl)ethoxy)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A243; 7-Cyclopentyl-2-((5-(2-(4-(1-(3-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)-piperazin-1-yl)ethoxy)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A244; 7-Cyclopentyl-N,N-dimethyl-2-((5-(4-(1-(4-(3-methyl-2,6-dioxopiperidin-3-yl)-phenethyl)piperidin-4-yl)piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A245; 7-Cyclopentyl-2-((5-(4-(2-(1-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)ethyl)piperidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A246; 7-Cyclopentyl-2-((5-(4-(2-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)ethyl)piperidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A247; 7-Cyclopentyl-2-((5-(4-(2-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-1-yl)ethyl)piperidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A248; 7-Cyclopentyl-2-((5-(3-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)propoxy)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A249; 7-Cyclopentyl-2-((5-(3-(1-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)propoxy)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A250; 7-Cyclopentyl-2-((5-(2-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)ethoxy)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A251; 7-Cyclopentyl-2-((5-(2-(1-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)ethoxy)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A252; 7-Cyclopentyl-2-((5-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)ethyl)-4-fluoro-[1,4'-bipiperidin]-1'-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A253; 7-Cyclopentyl-2-((5-(4-(1-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)-piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A254; 7-Cyclopentyl-2-((5-(4-(1-(3-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)-piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A255; 7-Cyclopentyl-2-((5-(4-((1-(4-(2,6-dioxopiperidin-3-yl)phenyl)azetidin-3-yl)-methyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A256; 7-Cyclopentyl-2-((5-(4-((1-(3-(2,6-dioxopiperidin-3-yl)phenyl)azetidin-3-yl)-methyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A257; 7-Cyclopentyl-2-((5-(4-(2-(1-(4-(2,6-dioxopiperidin-3-yl)phenyl)azetidin-3-yl)-ethyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A258; 7-Cyclopentyl-2-((5-(4-(2-(1-(3-(2,6-dioxopiperidin-3-yl)phenyl)azetidin-3-yl)-ethyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A259; 7-Cyclopentyl-2-((5-(4-(1-(2-(4-(2,6-dioxopiperidin-3-yl)phenyl)-2,2-difluoro-ethyl)piperidin-4-yl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A260; 7-Cyclopentyl-2-((5-(4-(1-(2-(3-(2,6-dioxopiperidin-3-yl)phenyl)-2,2-difluoro-ethyl)piperidin-4-yl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A261; 7-Cyclopentyl-2-((5-(4-(1-(2-(4-(2,6-dioxopiperidin-3-yl)phenyl)-2,2-difluoro-ethyl)azetidin-3-yl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A262; 7-Cyclopentyl-2-((5-(4-(1-(2-(3-(2,6-dioxopiperidin-3-yl)phenyl)-2,2-difluoro-ethyl)azetidin-3-yl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A263; 7-Cyclopentyl-2-((5-(4-(1-(4-(2,6-dioxopiperidin-3-yl)benzyl)azetidin-3-yl)-piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A264; 7-Cyclopentyl-2-((5-(4-(1-(3-(2,6-dioxopiperidin-3-yl)benzyl)azetidin-3-yl)-piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A265; 7-Cyclopentyl-2-((5-(4-(3-(2,6-dioxopiperidin-3-yl)phenethyl)-4-fluoro-[1,4'-bipiperidin]-1'-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A266; 7-Cyclopentyl-2-((5-(4-(4-(2,6-dioxopiperidin-3-yl)benzyl)-4-fluoro-[1,4'-bipiperidin]-1'-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A267; 7-Cyclopentyl-2-((5-(4-(3-(2,6-dioxopiperidin-3-yl)benzyl)-4-fluoro-[1,4'-bipiperidin]-1'-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A268; 7-Cyclopentyl-2-((5-(4-(3-(4-(2,6-dioxopiperidin-3-yl)phenethyl)-3-fluoro-azetidin-1-yl)piperidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A269; 7-Cyclopentyl-2-((5-(4-(3-(3-(2,6-dioxopiperidin-3-yl)phenethyl)-3-fluoro-azetidin-1-yl)piperidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A270; 7-Cyclopentyl-2-((5-(3-(1-(2-(4-(2,6-dioxopiperidin-3-yl)phenyl)-2,2-difluoro-ethyl)piperidin-4-yl)azetidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A271; 7-Cyclopentyl-2-((5-(3-(4-(4-(2,6-dioxopiperidin-3-yl)phenethyl)piperazin-1-yl)-azetidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A272; 7-Cyclopentyl-2-((5-(3-(4-(3-(2,6-dioxopiperidin-3-yl)phenethyl)piperazin-1-yl)-azetidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A273; 7-Cyclopentyl-2-((5-(3-(4-(4-(2,6-dioxopiperidin-3-yl)benzyl)piperazin-1-yl)azetidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A274; 7-Cyclopentyl-2-((5-(3-(4-(3-(2,6-dioxopiperidin-3-yl)benzyl)piperazin-1-yl)azetidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A275; 7-Cyclopentyl-2-((5-(4-(3-(4-(2,6-dioxopiperidin-3-yl)benzyl)-3-fluoroazetidin-1-yl)piperidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A276; 7-Cyclopentyl-2-((5-(4-(3-(3-(2,6-dioxopiperidin-3-yl)benzyl)-3-fluoroazetidin-1-yl)piperidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A277; 7-Cyclopentyl-2-((5-(3-(4-(4-(2,6-dioxopiperidin-3-yl)phenethyl)piperidin-1-yl)azetidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A278; 7-Cyclopentyl-2-((5-(3-(4-(4-(2,6-dioxopiperidin-3-yl)phenethyl)-4-fluoro-piperidin-1-yl)azetidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A279; 7-Cyclopentyl-2-((5-(3-(4-(3-(2,6-dioxopiperidin-3-yl)phenethyl)piperidin-1-yl)azetidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A280; 7-Cyclopentyl-2-((5-(3-(4-(3-(2,6-dioxopiperidin-3-yl)phenethyl)-4-fluoro-piperidin-1-yl)azetidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A281; 7-Cyclopentyl-2-((5-(3-(4-(3-(2,6-dioxopiperidin-3-yl)benzyl)-4-fluoropiperidin-1-yl)azetidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A282; 7-Cyclopentyl-2-((5-(3-(4-(4-(2,6-dioxopiperidin-3-yl)benzyl)-4-fluoropiperidin-1-yl)azetidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A283; 7-Cyclopentyl-2-((5-(4-((3-(4-(2,6-dioxopiperidin-3-yl)phenyl)azetidin-1-yl)-methyl)-4-fluoropiperidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A284; 7-Cyclopentyl-2-((5-(4-((3-(3-(2,6-dioxopiperidin-3-yl)phenyl)azetidin-1-yl)-methyl)-4-fluoropiperidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A285; 7-Cyclopentyl-2-((5-(1-((1-(3-(2,6-dioxopiperidin-3-yl)phenyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A286; 7-Cyclopentyl-2-((5-(1-((1-(4-(2,6-dioxopiperidin-3-yl)phenyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A287; 7-Cyclopentyl-2-((5-(4-((4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-1-yl)-methyl)-4-fluoropiperidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A288; 7-Cyclopentyl-2-((5-(4-((4-(3-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-1-yl)-methyl)-4-fluoropiperidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A289; 7-Cyclopentyl-2-((5-(4-(2-(1-(4-(2,6-dioxopiperidin-3-yl)-3-fluorophenyl)-piperidin-4-yl)ethyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A290; 7-Cyclopentyl-2-((5-(4-(2-(1-(4-(2,6-dioxopiperidin-3-yl)-2-fluorophenyl)-piperidin-4-yl)ethyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A291; 2-((5-(4-(2-(1-(3-chloro-4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)ethyl)-piperazin-1-yl)pyridin-2-yl)amino)-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A292; 2-((5-(4-(2-(1-(2-chloro-4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)ethyl)-piperazin-1-yl)pyridin-2-yl)amino)-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A293; 7-Cyclopentyl-2-((5-(3-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)-azetidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A294; 7-Cyclopentyl-2-((5-(4-(1-(4-(2,6-dioxopiperidin-3-yl)phenyl)azetidin-3-yl)-piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A295; 7-Cyclopentyl-2-((5-(3-(4-(3-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)-azetidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A296; 7-Cyclopentyl-2-((5-(4-(2-(1-(3-(2,6-dioxopiperidin-3-yl)-5-fluorophenyl)-piperidin-4-yl)ethyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A297; 7-Cyclopentyl-2-((5-(4-(2-(1-(3-(2,6-dioxopiperidin-3-yl)-4-fluorophenyl)-piperidin-4-yl)ethyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A298; 7-Cyclopentyl-2-((5-(4-(4-(2,6-dioxopiperidin-3-yl)-3-fluorophenethyl)-4-fluoro-[1,4'-bipiperidin]-1'-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A299; 7-Cyclopentyl-2-((5-((1'-(3-(2,6-dioxopiperidin-3-yl)phenyl)-[1,4'-bipiperidin]-4-yl)methoxy)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A300; 7-Cyclopentyl-2-((5-(3-(2-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-1-yl)-1,1-difluoroethyl)azetidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A351; 7-Cyclopentyl-2-((5-(4-(2-(1-(5-(2,6-dioxopiperidin-3-yl)-2-fluorophenyl)piperidin-4-yl)ethyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A352; 7-Cyclopentyl-2-((5-(4-(4-(2,6-dioxopiperidin-3-yl)-2-fluorophenethyl)-4-fluoro-[1,4'-bipiperidin]-1'-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A353; 7-Cyclopentyl-2-((4-((2-(4-(2-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-phenoxy)acetyl)piperazin-1-yl)ethyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A401; 7-Cyclopentyl-2-((4-((4-(4-(2-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-phenoxy)acetyl)piperazin-1-yl)butyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A402; 7-Cyclopentyl-2-((4-((6-(4-(2-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-phenoxy)acetyl)piperazin-1-yl)hexyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A403; 7-Cyclopentyl-2-((4-((2-(4-(2-(4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-phenoxy)acetyl)piperazin-1-yl)ethyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A404; 7-Cyclopentyl-2-((4-((4-(4-(2-(4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-phenoxy)acetyl)piperazin-1-yl)butyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A405; 7-Cyclopentyl-2-((4-((6-(4-(2-(4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-phenoxy)acetyl)piperazin-1-yl)hexyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A406; 7-Cyclopentyl-2-((4-(4-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)phenyl)-piperazin-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A407; 7-Cyclopentyl-2-((5-(4-(4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)phenyl)-piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A408; 7-Cyclopentyl-2-((4-(4-(4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)benzyl)-piperazin-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A409; 7-Cyclopentyl-2-((4-(4-(4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)phenethyl)-piperazin-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A410; 7-Cyclopentyl-2-((5-(4-(2-(4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)phenoxy)-ethyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A411; 7-Cyclopentyl-2-((4-(2-(4-(4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)phenyl)piperazin-1-yl)ethyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A412; 7-Cyclopentyl-2-((4-(2-(4-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)phenyl)piperazin-1-yl)ethyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A413; 7-Cyclopentyl-2-((5-((4-(4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)phenyl)piperazin-1-yl)methyl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A414; 7-Cyclopentyl-2-((5-(2-(4-(4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)phenyl)piperazin-1-yl)ethoxy)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A415; 7-Cyclopentyl-2-((4-(2-(4-(4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)phenyl)piperazin-1-yl)ethoxy)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A416; 7-Cyclopentyl-2-((4-(2-(4-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)phenyl)piperazin-1-yl)ethoxy)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A417; 7-Cyclopentyl-2-((4-(2-(4-(4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)benzyl)piperazin-1-yl)ethoxy)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A418; 7-Cyclopentyl-2-((5-((4-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)phenyl)-piperazin-1-yl)methyl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A419; 7-Cyclopentyl-2-((4-(4-(1-(4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)phenyl)-piperidin-4-yl)piperazin-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A420; 7-Cyclopentyl-2-((4-(4-(1-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)phenyl)-piperidin-4-yl)piperazin-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A421; 7-Cyclopentyl-2-((4-(2-(4-(4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)benzyl)-piperazin-1-yl)ethyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A422; 7-Cyclopentyl-2-((4-(2-(4-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)benzyl)-piperazin-1-yl)ethyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A423; 7-Cyclopentyl-2-((4-(2-(4-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)benzyl)-piperazin-1-yl)ethoxy)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A424; 7-Cyclopentyl-2-((4-(2-(4-(4-(4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)phenyl)-piperazin-1-yl)piperidin-1-yl)ethyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A425; 7-Cyclopentyl-2-((4-(2-(4-(4-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)phenyl)piperazin-1-yl)piperidin-1-yl)ethyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A426; 7-Cyclopentyl-2-((4-(2-(4-(4-(4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)phenyl)piperazin-1-yl)piperidin-1-yl)ethoxy)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A427; 7-Cyclopentyl-2-((4-(4-(1-(4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)phenyl)phenethyl)piperidin-4-yl)piperazin-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A428; 7-Cyclopentyl-2-((4-(4-(1-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)phenyl)phenethyl)piperidin-4-yl)piperazin-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A429; 7-Cyclopentyl-2-((5-(4-(1-(4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)benzyl)piperidin-4-yl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A430; 7-Cyclopentyl-2-((4-(4-((1-(4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)phenyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A431; 7-Cyclopentyl-2-((4-(4-((1-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)phenyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A432; 7-Cyclopentyl-2-((4-(4-(2-(4-(4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)phenyl)piperidin-1-yl)ethyl)piperazin-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A433; 7-Cyclopentyl-2-((4-(4-(2-(4-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)phenyl)piperidin-1-yl)ethyl)piperazin-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A434; 7-Cyclopentyl-2-((5-(4-(1-(4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)phenethyl)piperidin-4-yl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A435; 2-((5-(4-(2-(1-(3-chloro-4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)phenyl)piperidin-4-yl)ethyl)piperazin-1-yl)pyridin-2-yl)amino)-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A436; 7-Cyclopentyl-2-((5-(4-((1-(4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)phenyl)piperidin-4-yl)methyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A437; 2-((5-(4-((1-(3-chloro-4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)phenyl)piperidin-4-yl)methyl)piperazin-1-yl)pyridin-2-yl)amino)-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A438; 7-Cyclopentyl-2-((5-(4-(1-(4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)phenyl)piperidin-4-yl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A439; 2-((5-(4-(1-(2-(3-chloro-4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)phenyl)-2,2-difluoroethyl)piperidin-4-yl)piperazin-1-yl)pyridin-2-yl)amino)-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A440; 7-Cyclopentyl-2-((4-((2-(4-(2-((3-(2,6-dioxopiperidin-3-yl)-1-methyl-1H-indazol-7-yl)oxy)acetyl)piperazin-1-yl)ethyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A501; 7-Cyclopentyl-2-((4-((4-(4-(2-((3-(2,6-dioxopiperidin-3-yl)-1-methyl-1H-indazol-7-yl)oxy)acetyl)piperazin-1-yl)butyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A502; 7-Cyclopentyl-2-((4-((6-(4-(2-((3-(2,6-dioxopiperidin-3-yl)-1-methyl-1H-indazol-7-yl)oxy)acetyl)piperazin-1-yl)hexyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A503; 7-Cyclopentyl-2-((4-((2-(4-(2-((3-(2,6-dioxopiperidin-3-yl)-1-methyl-1H-indazol-6-yl)oxy)acetyl)piperazin-1-yl)ethyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A504; 7-Cyclopentyl-2-((4-((4-(4-(2-((3-(2,6-dioxopiperidin-3-yl)-1-methyl-1H-indazol-6-yl)oxy)acetyl)piperazin-1-yl)butyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A505; 7-Cyclopentyl-2-((4-((6-(4-(2-((3-(2,6-dioxopiperidin-3-yl)-1-methyl-1H-indazol-6-yl)oxy)acetyl)piperazin-1-yl)hexyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A506; 7-Cyclopentyl-2-((4-((2-(4-(2-((3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-1-methyl-1H-indazol-7-yl)oxy)acetyl)piperazin-1-yl)ethyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A551; 7-Cyclopentyl-2-((4-((4-(4-(2-((3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-1-methyl-1H-indazol-7-yl)oxy)acetyl)piperazin-1-yl)butyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A552; 7-Cyclopentyl-2-((4-((6-(4-(2-((3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-1-methyl-1H-indazol-7-yl)oxy)acetyl)piperazin-1-yl)hexyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A553; 7-Cyclopentyl-2-((4-((2-(4-(2-((3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-1-methyl-1H-indazol-6-yl)oxy)acetyl)piperazin-1-yl)ethyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A554; 7-Cyclopentyl-2-((4-((4-(4-(2-((3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-1-methyl-1H-indazol-6-yl)oxy)acetyl)piperazin-1-yl)butyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A555; 7-Cyclopentyl-2-((4-((6-(4-(2-((3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-1-methyl-1H-indazol-6-yl)oxy)acetyl)piperazin-1-yl)hexyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A556; 7-Cyclopentyl-2-((5-(4-(2-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-1-methyl-1H-indazol-6-yl)ethyl)-4-fluoro-[1,4'-bipiperidin]-1'-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A557; 7-Cyclopentyl-2-((5-(4-(2-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-1-methyl-1H-indazol-7-yl)ethyl)-4-fluoro-[1,4'-bipiperidin]-1'-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A558; 7-Cyclopentyl-2-((5-(4-(2-(1-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-1-methyl-1H-indazol-6-yl)piperidin-4-yl)ethyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A559; 7-Cyclopentyl-2-((4-((6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-amino)hexyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A601; 7-Cyclopentyl-2-((4-((6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-amino)hexyl)(methyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A602; 7-Cyclopentyl-2-((5-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-glycyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A603; 7-Cyclopentyl-2-((5-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)-glycyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A611; 7-Cyclopentyl-2-((4-((2-(4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-4-yl)piperidin-1-yl)ethyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A612; 7-Cyclopentyl-2-((4-((4-(4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-4-yl)piperidin-1-yl)butyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A613; 7-Cyclopentyl-2-((4-((6-(4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-4-yl)piperidin-1-yl)hexyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A614; 7-Cyclopentyl-2-((5-(4-(2-(4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-4-yl)piperidin-1-yl)acetyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A615; 7-Cyclopentyl-2-((5-(4-(3-(4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-4-yl)piperidin-1-yl)propanoyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A616; 7-Cyclopentyl-2-((5-(4-(4-(4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-4-yl)piperidin-1-yl)butanoyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A617; 7-Cyclopentyl-2-((4-((2-(4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)piperidin-1-yl)ethyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A618; 7-Cyclopentyl-2-((4-((4-(4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)piperidin-1-yl)butyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A619; 7-Cyclopentyl-2-((4-((6-(4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)piperidin-1-yl)hexyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A620; 7-Cyclopentyl-2-((5-(4-(2-(4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)piperidin-1-yl)acetyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A621; 7-Cyclopentyl-2-((5-(4-(3-(4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)piperidin-1-yl)propanoyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A622; 7-Cyclopentyl-2-((5-(4-(4-(4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)piperidin-1-yl)butanoyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A623; 7-Cyclopentyl-2-((4-((4-((5-(2,6-dioxopiperidin-3-yl)-4-oxo-5,6-dihydro-4H-thieno[3,4-c]pyrrol-1-yl)methoxy)benzyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A651; 7-Cyclopentyl-2-((4-((2-((4-((5-(2,6-dioxopiperidin-3-yl)-4-oxo-5,6-dihydro-4H-thieno[3,4-c]pyrrol-1-yl)methoxy)benzyl)amino)ethyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A652; 7-Cyclopentyl-2-((4-((4-((4-((5-(2,6-dioxopiperidin-3-yl)-4-oxo-5,6-dihydro-4H-thieno[3,4-c]pyrrol-1-yl)methoxy)benzyl)amino)butyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A653; 7-Cyclopentyl-2-((4-((4-((5-(2,6-dioxopiperidin-3-yl)-4-oxo-5,6-dihydro-4H-thieno[3,4-c]pyrrol-1-yl)methoxy)benzyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo-[2,3-d]pyrimidine-6-carboxamide A654; 3-(3-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)-2-oxoethoxy)phenyl)piperidine-2,6-dione B101; 3-(3-(3-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)-3-oxopropoxy)phenyl)piperidine-2,6-dione B102; N-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)-2-(3-(2,6-dioxopiperidin-3-yl)-2-methylphenoxy)acetamide B103; N-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)-2-(3-(2,6-dioxopiperidin-3-yl)-2-(trifluoromethyl)phenoxy)acetamide B104; N-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)-2-(3-(2,6-dioxopiperidin-3-yl)-4-methylphenoxy)acetamide B105; N-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)-2-(3-(2,6-dioxopiperidin-3-yl)-4-(trifluoromethyl)phenoxy)acetamide B106; N-(3-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)propyl)-2-(3-(2,6-dioxopiperidin-3-yl)-2-methylphenoxy)acetamide B107; N-(3-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)propyl)-2-(3-(2,6-dioxopiperidin-3-yl)-2-(trifluoromethyl)phenoxy)acetamide B108; N-(3-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)propyl)-2-(3-(2,6-dioxopiperidin-3-yl)-4-methylphenoxy)acetamide B109; N-(3-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)propyl)-2-(3-(2,6-dioxopiperidin-3-yl)-4-(trifluoromethyl)phenoxy)acetamide B110; 3-(4-((4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)methyl)phenyl)piperidine-2,6-dione B111; 3-(4-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)phenyl)piperidine-2,6-dione B112; 3-(4-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethoxy)phenyl)piperidine-2,6-dione B113; 3-(3-((4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)methyl)phenyl)piperidine-2,6-dione B114; 3-(3-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)phenyl)piperidine-2,6-dione B115; 3-(3-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethoxy)phenyl)piperidine-2,6-dione B116; 3-(4-(3-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)propoxy)phenyl)piperidine-2,6-dione B117; 3-(3-(3-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)propoxy)phenyl)piperidine-2,6-dione B118; 3-(4-(4-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)phenyl)piperidine-2,6-dione B119; 3-(4-(4-((4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)methyl)piperidin-1-yl)phenyl)piperidine-2,6-dione B120; 3-(4-((4-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)methyl)phenyl)piperidine-2,6-dione B121; 3-(3-(4-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)phenyl)piperidine-2,6-dione B122; 3-(3-(4-((4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)methyl)piperidin-1-yl)phenyl)piperidine-2,6-dione B123; 3-(3-((4-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)methyl)phenyl)piperidine-2,6-dione B124; 3-(4-(4-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperazin-1-yl)phenyl)piperidine-2,6-dione B125; 3-(3-(4-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperazin-1-yl)phenyl)piperidine-2,6-dione B126; 3-(4-(2-(4-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)ethyl)phenyl)piperidine-2,6-dione B127; 3-(3-(2-(4-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)ethyl)phenyl)piperidine-2,6-dione B128; 3-(4-((1-(2-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)ethyl)piperidin-4-yl)oxy)phenyl)piperidine-2,6-dione B129; 3-(3-((1-(2-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)ethyl)piperidin-4-yl)oxy)phenyl)piperidine-2,6-dione B130; 3-(4-((1-(3-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)propyl)piperidin-4-yl)oxy)phenyl)piperidine-2,6-dione B131; 3-(4-(4-(2-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)ethyl)piperazin-1-yl)phenyl)piperidine-2,6-dione B132; 3-(4-(4-(2-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)ethyl)piperidin-1-yl)phenyl)piperidine-2,6-dione B133; 3-(4-(4-(3-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)propyl)piperazin-1-yl)phenyl)piperidine-2,6-dione B134; 3-(3-(4-(2-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)ethyl)piperazin-1-yl)phenyl)piperidine-2,6-dione B135; 3-(3-(4-(3-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)propyl)piperazin-1-yl)phenyl)piperidine-2,6-dione B136; 3-(4-(3-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)propoxy)phenyl)-piperidine-2,6-dione B137; 3-(3-(3-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)propoxy)phenyl)-piperidine-2,6-dione B138; 3-(4-(4-(4-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)benzyl)piperazin-1-yl)phenyl)piperidine-2,6-dione B139; 3-(4-(4-(3-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)benzyl)piperazin-1-yl)phenyl)piperidine-2,6-dione B140; 3-(3-(4-(3-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)benzyl)piperazin-1-yl)phenyl)piperidine-2,6-dione B141; 3-(3-(4-(4-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)benzyl)piperazin-1-yl)phenyl)piperidine-2,6-dione B142; 3-(4-((4-(4-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)phenyl)piperazin-1-yl)methyl)phenyl)piperidine-2,6-dione B143; 3-(4-(4-((4-(4-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methyl-cyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)-phenyl)piperazin-1-yl)methyl)piperidin-1-yl)phenyl)piperidine-2,6-dione B144; 3-(4-((4-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)piperazin-1-yl)-methyl)phenyl)piperidine-2,6-dione B145; 3-(3-((4-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)piperazin-1-yl)-methyl)phenyl)piperidine-2,6-dione B146; 3-(4-(4-((4-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)piperazin-1-yl)-methyl)piperidin-1-yl)phenyl)piperidine-2,6-dione B147; 3-(4-(4-(3-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)propyl)piperazin-1-yl)phenyl)piperidine-2,6-dione B148; 3-(3-((1-(3-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)propyl)piperidin-4-yl)oxy)phenyl)piperidine-2,6-dione B149; 3-(4-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperidin-1-yl)phenyl)piperidine-2,6-dione B150; 3-(4-(2-(4-(4-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)phenyl)-piperazin-1-yl)ethyl)phenyl)piperidine-2,6-dione B151; 3-(4-(2-(4-(4-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)phenyl)-piperazin-1-yl)ethoxy)phenyl)piperidine-2,6-dione B152; 3-(4-(2-(4-(3-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)phenyl)-piperazin-1-yl)ethyl)phenyl)piperidine-2,6-dione B153; 3-(3-(2-(4-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)piperazin-1-yl)-ethoxy)phenyl)piperidine-2,6-dione B154; 3-(4-(3-(4-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)piperazin-1-yl)-propoxy)phenyl)piperidine-2,6-dione B155; 3-(3-(3-(4-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)piperazin-1-yl)-propoxy)phenyl)piperidine-2,6-dione B156; 3-(4-(4-(4-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)phenethyl)-piperazin-1-yl)phenyl)piperidine-2,6-dione B157; 3-(4-(4-(2-(4-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclo-pentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)phenoxy)-ethyl)piperazin-1-yl)phenyl)piperidine-2,6-dione B158; 3-(4-(4-(2-(3-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclo-pentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)phenoxy)-ethyl)piperazin-1-yl)phenyl)piperidine-2,6-dione B159; 3-(3-((1-(3-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)phenyl)piperidin-4-yl)oxy)phenyl)piperidine-2,6-dione B160; 3-(4-((1-(3-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)phenyl)piperidin-4-yl)oxy)phenyl)piperidine-2,6-dione B161; 3-(4-((1-(4-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)phenyl)piperidin-4-yl)oxy)phenyl)piperidine-2,6-dione B162; 3-(4-(4-(3-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)propyl)piperazin-1-yl)phenyl)piperidine-2,6-dione B163; 3-(4-(4-((4-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)methyl)piperidin-1-yl)-phenyl)piperidine-2,6-dione B164; 3-(4-(4-((4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)methyl)-[1,4'-bipiperidin]-1'-yl)phenyl)-piperidine-2,6-dione B165; 3-(4-(4-(1-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperidin-4-yl)piperazin-1-yl)-phenyl)piperidine-2,6-dione B166; 3-(4-(4-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)-[1,4'-bipiperidin]-1'-yl)phenyl)-piperidine-2,6-dione B167; 3-(4-(4-(3-((4-((8-Cyclopentyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)-amino)piperidin-1-yl)sulfonyl)propyl)piperazin-1-yl)phenyl)piperidine-2,6-dione B168; 3-(4-(4-(3-((4-((8-Cyclopentyl-6-(difluoromethyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)propyl)piperazin-1-yl)phenyl)piperidine-2,6-dione B169; 3-(4-(3-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)-[1,4'-bipiperidin]-1'-yl)phenyl)piperidine-2,6-dione B170; 3-(4-(4-((3-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)methyl)piperidin-1-yl)-phenyl)piperidine-2,6-dione B171; 3-(4-((S)-2-((4-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)methyl)-morpholino)phenyl)piperidine-2,6-dione B172; 3-(4-((R)-2-((4-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)methyl)-morpholino)phenyl)piperidine-2,6-dione B173; 3-(4-((4-(3-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)cyclohexyl)piperidin-1-yl)methyl)-phenyl)piperidine-2,6-dione B174; 3-(4-(2-(4-(3-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)cyclohexyl)piperidin-1-yl)ethyl)-phenyl)piperidine-2,6-dione B175; 3-(4-(3-((4-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)methyl)azetidin-1-yl)-phenyl)piperidine-2,6-dione B176; 3-(4-(4-((S)-2-((4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)methyl)morpholino)piperidin-1-yl)phenyl)piperidine-2,6-dione B177; 3-(4-(4-((R)-2-((4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)methyl)morpholino)piperidin-1-yl)phenyl)piperidine-2,6-dione B178; 3-(4-(4-(4-((4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)methyl)cyclohexyl)piperazin-1-yl)-phenyl)piperidine-2,6-dione B179; 3-(4-(4-(2-(4-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)ethyl)piperazin-1-yl)-phenyl)piperidine-2,6-dione B180; 3-(4-(2-(4-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)cyclohexyl)ethyl)phenyl)piperidine-2,6-dione B181; 3-(4-(4-(3-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)cyclohexyl)piperazin-1-yl)phenyl)-piperidine-2,6-dione B182; 3-(4-(4-(3-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)propyl)piperidin-1-yl)phenyl)piperidine-2,6-dione B183; 3-(4-(3-(4-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)propoxy)phenyl)piperidine-2,6-dione B184; 3-(4-(1'-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)-[4,4'-bipiperidin]-1-yl)phenyl)-piperidine-2,6-dione B185; 3-(4-(4-((3-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)azetidin-1-yl)methyl)piperidin-1-yl)-phenyl)piperidine-2,6-dione B186; 3-(4-(4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)-[1,4'-bipiperidin]-1'-yl)phenyl)piperidine-2,6-dione B187; 3-(4-(4-(1'-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)-[1,4'-bipiperidin]-4-yl)piperazin-1-yl)phenyl)piperidine-2,6-dione B188; 3-(4-(4-(4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)cyclohexyl)piperazin-1-yl)phenyl)-piperidine-2,6-dione B189; 3-(4-(4-(4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)cyclohexyl)piperidin-1-yl)phenyl)-piperidine-2,6-dione B190; 3-(3-(2-(4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)ethoxy)phenyl)piperidine-2,6-dione B191; 3-(3-(3-(4-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)propoxy)phenyl)piperidine-2,6-dione B192; 3-(4-(4-(1-((6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperidin-4-yl)piperazin-1-yl)phenyl)piperidine-2,6-dione B193; 3-(4-(4-(4-((6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazin-1-yl)piperidin-1-yl)phenyl)piperidine-2,6-dione B194; 3-(4-(1'-((6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)methyl)-[4,4'-bipiperidin]-1-yl)phenyl)piperidine-2,6-dione B195; 3-(4-(4-((6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)methyl)-[1,4'-bipiperidin]-1'-yl)phenyl)piperidine-2,6-dione B196; 3-(4-(4-((6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)oxy)-[1,4'-bipiperidin]-1'-yl)phenyl)piperidine-2,6-dione B197; 3-(4-(4-(2-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)ethyl)-[1,4'-bipiperidin]-1'-yl)phenyl)piperidine-2,6-dione B198; 3-(4-(4-(((6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)oxy)methyl)-[1,4'-bipiperidin]-1'-yl)phenyl)piperidine-2,6-dione B199; 3-(4-(4-(4-(2-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)ethyl)piperazin-1-yl)piperidin-1-yl)phenyl)piperidine-2,6-dione B200; 3-(4-(4-(1-(2-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)ethyl)piperidin-4-yl)piperazin-1-yl)phenyl)piperidine-2,6-dione B201; 3-(4-(1'-(2-((6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)oxy)ethyl)-[4,4'-bipiperidin]-1-yl)phenyl)piperidine-2,6-dione B202; 3-(4-(4-(1-(2-((6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)oxy)ethyl)piperidin-4-yl)piperazin-1-yl)phenyl)-piperidine-2,6-dione B203; 3-(4-(4-(4-(2-((6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)oxy)ethyl)piperazin-1-yl)piperidin-1-yl)phenyl)-piperidine-2,6-dione B204; 3-(4-(4-(2-((6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)oxy)ethyl)-[1,4'-bipiperidin]-1'-yl)phenyl)piperidine-2,6-dione B205; 3-(4-(1'-(3-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)propyl)-[4,4'-bipiperidin]-1-yl)phenyl)piperidine-2,6-dione B206; 3-(4-(4-(1-(3-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)propyl)piperidin-4-yl)piperazin-1-yl)phenyl)piperidine-2,6-dione B207; 3-(4-(4-(4-(3-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)propyl)piperazin-1-yl)piperidin-1-yl)phenyl)piperidine-2,6-dione B208; 3-(4-(4-(3-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidin-2-yl)amino)pyridin-3-yl)propyl)-[1,4'-bipiperidin]-1'-yl)phenyl)piperidine-2,6-dione B209; 3-(3-(4-((1-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)piperidine-2,6-dione B210; 3-(4-(4-(((S)-4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)morpholin-2-yl)methyl)piperazin-1-yl)phenyl)-piperidine-2,6-dione B211; 3-(4-(4-(((R)-4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)morpholin-2-yl)methyl)piperazin-1-yl)phenyl)-piperidine-2,6-dione B212; 3-(3-(4-(((S)-4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)morpholin-2-yl)methyl)piperazin-1-yl)phenyl)-piperidine-2,6-dione B213; 3-(4-(2-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)ethyl)phenyl)piperidine-2,6-dione B214; 3-(4-(2-(1'-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)-[1,4'-bipiperidin]-4-yl)ethyl)phenyl)piperidine-2,6-dione B215; 3-(4-((S)-2-((4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)methyl)morpholino)phenyl)piperidine-2,6-dione B216; 3-(4-((R)-2-((4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)methyl)morpholino)phenyl)piperidine-2,6-dione B217; 3-(4-(3-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidin-2-yl)amino)pyridin-3-yl)oxy)-[1,4'-bipiperidin]-1'-yl)phenyl)piperidine-2,6-dione B218; 3-(4-(4-(1-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperidin-3-yl)piperazin-1-yl)phenyl)piperidine-2,6-dione B219; 3-(3-(4-(1-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperidin-3-yl)piperazin-1-yl)phenyl)piperidine-2,6-dione B220; 3-(4-(4-(1-(2-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)oxy)ethyl)piperidin-3-yl)piperazin-1-yl)phenyl)-piperidine-2,6-dione B221; 3-(3-(4-(1-(2-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)oxy)ethyl)piperidin-3-yl)piperazin-1-yl)phenyl)-piperidine-2,6-dione B222; 3-(3-(4-(1-((1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)piperidin-4-yl)piperazin-1-yl)-phenyl)piperidine-2,6-dione B223; 3-(4-(4-(1-((1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)piperidin-4-yl)piperazin-1-yl)-phenyl)piperidine-2,6-dione B224; 3-(4-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)phenyl)piperidine-2,6-dione B225; 3-(4-(4-((1-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)azetidin-3-yl)methyl)piperazin-1-yl)phenyl)piperidine-2,6-dione B226; 3-(4-(4-(2-(1-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)ethyl)piperazin-1-yl)phenyl)piperidine-2,6-dione B227; 3-(4-(3-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)azetidin-1-yl)phenyl)piperidine-2,6-dione B228; 3-(4-(2-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)-2,7-diazaspiro[3.5]nonan-7-yl)phenyl)piperidine-2,6-dione B229; 3-(4-(4-(3-((6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)oxy)propyl)piperazin-1-yl)phenyl)piperidine-2,6-dione B230; 3-(4-(1-(3-((6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)oxy)propyl)piperidin-4-yl)phenyl)piperidine-2,6-dione B231; 3-(3-(4-(3-((6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)oxy)propyl)piperazin-1-yl)phenyl)piperidine-2,6-dione B232; 3-(3-(1-(3-((6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)oxy)propyl)piperidin-4-yl)phenyl)piperidine-2,6-dione B233; 3-(4-(3-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-1-yl)propoxy)phenyl)piperidine-2,6-dione B234; 3-(4-(4-(3-((6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)oxy)propyl)piperidin-1-yl)phenyl)piperidine-2,6-dione B235; 3-(3-(4-(3-((6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)oxy)propyl)piperidin-1-yl)phenyl)piperidine-2,6-dione B236; 3-(4-(3-(1-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)propoxy)phenyl)piperidine-2,6-dione B237; 3-(4-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)-[1,4'-bipiperidin]-1'-yl)phenyl)piperidine-2,6-dione B238; 3-(4-(1'-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)-[4,4'-bipiperidin]-1-yl)phenyl)piperidine-2,6-dione B239; 3-(4-(4-(1-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)phenyl)piperidine-2,6-dione B240; 3-(4-(1'-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)-[1,4'-bipiperidin]-4-yl)phenyl)piperidine-2,6-dione B241; 3-(3-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)-[1,4'-bipiperidin]-1'-yl)phenyl)piperidine-2,6-dione B242; 3-(3-(1'-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)-[4,4'-bipiperidin]-1-yl)phenyl)piperidine-2,6-dione B243; 3-(3-(4-(1-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)phenyl)piperidine-2,6-dione B244; 3-(3-(1'-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)-[1,4'-bipiperidin]-4-yl)phenyl)piperidine-2,6-dione B245; 3-(4-(4-((4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-1-yl)methyl)piperidin-1-yl)phenyl)piperidine-2,6-dione B246; 3-(4-(4-((1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)piperidine-2,6-dione B247; 3-(4-(1-((1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)piperidin-4-yl)phenyl)piperidine-2,6-dione B248; 3-(3-(4-((4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-1-yl)methyl)piperidin-1-yl)phenyl)piperidine-2,6-dione B249; 3-(3-(1-((1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)piperidin-4-yl)phenyl)piperidine-2,6-dione B250; 3-(3-(4-((1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)methyl)piperidin-1-yl)phenyl)piperidine-2,6-dione B251; 3-(4-(1'-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidin-2-yl)amino)pyridin-3-yl)methyl)-[1,4'-bipiperidin]-4-yl)phenyl)piperidine-2,6-dione B252; 3-(4-(1-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperidin-4-yl)phenyl)piperidine-2,6-dione B253; 3-(4-(1-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-1-yl)ethyl)piperidin-4-yl)phenyl)piperidine-2,6-dione B254; 3-(4-(4-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-1-yl)ethyl)piperazin-1-yl)phenyl)piperidine-2,6-dione B255; 3-(4-(4-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-1-yl)ethyl)piperidin-1-yl)phenyl)piperidine-2,6-dione B256; 3-(3-(1-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperidin-4-yl)phenyl)piperidine-2,6-dione B257; 3-(3-(1-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-1-yl)ethyl)piperidin-4-yl)phenyl)piperidine-2,6-dione B258; 3-(3-(4-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-1-yl)ethyl)piperazin-1-yl)phenyl)piperidine-2,6-dione B259; 3-(3-(4-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-1-yl)ethyl)piperidin-1-yl)phenyl)piperidine-2,6-dione B260; 3-(3-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperidin-1-yl)phenyl)piperidine-2,6-dione B261; 3-(4-(2-(1'-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)-[4,4'-bipiperidin]-1-yl)ethyl)phenyl)piperidine-2,6-dione B262; 3-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)-[1,4'-bipiperidin]-1'-yl)ethyl)phenyl)piperidine-2,6-dione B263; 3-(3-(4-(4-(2-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)ethyl)piperazin-1-yl)piperidin-1-yl)phenyl)piperidine-2,6-dione B264; 3-(3-(4-(2-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)ethyl)-[1,4'-bipiperidin]-1'-yl)phenyl)piperidine-2,6-dione B265; 3-(3-(4-(((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)oxy)methyl)-[1,4'-bipiperidin]-1'-yl)phenyl)piperidine-2,6-dione B266; 3-(3-(1'-(2-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)ethyl)-[4,4'-bipiperidin]-1-yl)phenyl)piperidine-2,6-dione B267; 3-(3-(4-(1-(2-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)ethyl)piperidin-4-yl)piperazin-1-yl)phenyl)piperidine-2,6-dione B268; 3-(3-(4-(1-(2-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)oxy)ethyl)piperidin-4-yl)piperazin-1-yl)phenyl)-piperidine-2,6-dione B269; 3-(3-(4-(4-(2-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)oxy)ethyl)piperazin-1-yl)piperidin-1-yl)phenyl)-piperidine-2,6-dione B270; 3-(4-(1'-(2-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)oxy)ethyl)-[1,4'-bipiperidin]-4-yl)phenyl)piperidine-2,6-dione B271; 3-(4-(4-(2-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)ethyl)piperidin-1-yl)phenyl)piperidine-2,6-dione B272; (S)-3-(4-(4-(((S)-4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)morpholin-2-yl)methyl)piperazin-1-yl)phenyl)-3-methylpiperidine-2,6-dione B273; 3-(4-(1-(2-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)ethyl)piperidin-4-yl)phenyl)piperidine-2,6-dione B274; 3-(4-((1'-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)-[1,4'-bipiperidin]-4-yl)methyl)phenyl)piperidine-2,6-dione B275; 3-(4-(4-(2-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)oxy)ethyl)piperazin-1-yl)phenyl)piperidine-2,6-dione B276; 3-(4-(4-(2-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)oxy)ethyl)piperidin-1-yl)phenyl)piperidine-2,6-dione B277; 3-(4-(2-(1'-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)-4-fluoro-[1,4'-bipiperidin]-4-yl)ethyl)phenyl)piperidine-2,6-dione B278; 3-(3-(3-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)azetidin-1-yl)phenyl)piperidine-2,6-dione B279; 3-(4-(2-(4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)-1,1-difluoroethyl)phenyl)-piperidine-2,6-dione B280; 3-(3-(2-(4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)-1,1-difluoroethyl)phenyl)piperidine-2,6-dione B281; 3-(4-(2-(3-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)azetidin-1-yl)-1,1-difluoroethyl)phenyl)piperidine-2,6-dione B282; 3-(3-(2-(3-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)azetidin-1-yl)-1,1-difluoroethyl)phenyl)piperidine-2,6-dione B283; 3-(4-((3-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)azetidin-1-yl)methyl)phenyl)piperidine-2,6-dione B284; 3-(3-((3-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)azetidin-1-yl)methyl)phenyl)piperidine-2,6-dione B285; 3-(3-(2-(1'-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)-4-fluoro-[1,4'-bipiperidin]-4-yl)ethyl)phenyl)piperidine-2,6-dione B286; 3-(4-((1'-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)-4-fluoro-[1,4'-bipiperidin]-4-yl)methyl)phenyl)piperidine-2,6-dione B287; 3-(3-((1'-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)-4-fluoro-[1,4'-bipiperidin]-4-yl)methyl)phenyl)piperidine-2,6-dione B288; 3-(4-(2-(1-(1-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)-3-fluoroazetidin-3-yl)ethyl)phenyl)-piperidine-2,6-dione B289; 3-(3-(2-(1-(1-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)-3-fluoroazetidin-3-yl)ethyl)phenyl)-piperidine-2,6-dione B290; 3-(4-((1-(1-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)-3-fluoroazetidin-3-yl)methyl)phenyl)-piperidine-2,6-dione B291; 3-(3-((1-(1-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)-3-fluoroazetidin-3-yl)methyl)phenyl)-piperidine-2,6-dione B292; 3-(4-(1-((1-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)-4-fluoropiperidin-4-yl)methyl)azetidin-3-yl)phenyl)-piperidine-2,6-dione B293; 3-(3-(1-((1-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)-4-fluoropiperidin-4-yl)methyl)azetidin-3-yl)phenyl)-piperidine-2,6-dione B294; 3-(4-(2-(4-(1-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)azetidin-3-yl)piperazin-1-yl)ethyl)phenyl)piperidine-2,6-dione B295; 3-(3-(2-(4-(1-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)azetidin-3-yl)piperazin-1-yl)ethyl)phenyl)piperidine-2,6-dione B296; 3-(4-((4-(1-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)azetidin-3-yl)piperazin-1-yl)methyl)phenyl)piperidine-2,6-dione B297; 3-(3-((4-(1-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)azetidin-3-yl)piperazin-1-yl)methyl)phenyl)piperidine-2,6-dione B298; 3-(3-(2-(1-(1-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)azetidin-3-yl)piperidin-4-yl)ethyl)phenyl)piperidine-2,6-dione B299; 3-(3-(2-(1-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)azetidin-3-yl)-4-fluoropiperidin-4-yl)ethyl)phenyl)-piperidine-2,6-dione B300; 3-(3-(8-((4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)methyl)-3-azabicyclo[3.2.1]octan-3-yl)phenyl)piperidine-2,6-dione B301; 3-(3-(3-((4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)methyl)-8-azabicyclo[3.2.1]octan-8-yl)phenyl)piperidine-2,6-dione B302; 3-(3-(4-((3-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methyl)piperidin-1-yl)phenyl)piperidine-2,6-dione B303; 3-(3-(4-((8-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)-3,8-diazabicyclo[3.2.1]octan-3-yl)methyl)piperidin-1-yl)phenyl)piperidine-2,6-dione B304; 3-(3-(4-((4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-1-yl)methyl)-4-fluoropiperidin-1-yl)phenyl)-piperidine-2,6-dione B305; 3-(4-(4-((4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-1-yl)methyl)-4-fluoropiperidin-1-yl)phenyl)-piperidine-2,6-dione B306; (S)-3-(4-(4-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperidin-1-yl)phenyl)-3-methyl-piperidine-2,6-dione B307; (R)-3-(4-(4-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperidin-1-yl)phenyl)-3-methyl-piperidine-2,6-dione B308; (S)-3-(4-(4-(1-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)phenyl)-3-methyl-piperidine-2,6-dione B309; (R)-3-(4-(4-(1-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)phenyl)-3-methyl-piperidine-2,6-dione B310; 3-(4-(1-((1-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)phenyl)-piperidine-2,6-dione B311; 3-(3-(1-((1-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)phenyl)-piperidine-2,6-dione B312; 3-(4-(4-(1-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)-2-fluorophenyl)piperidine-2,6-dione B313; 3-(4-(4-(1-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)-3-fluorophenyl)piperidine-2,6-dione B314; 3-(4-(4-(1-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)-2-chlorophenyl)piperidine-2,6-dione B315; 3-(4-(4-(1-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)-3-chlorophenyl)piperidine-2,6-dione B316; 3-(4-(3-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)azetidin-1-yl)phenyl)piperidine-2,6-dione B317; 3-(3-(4-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperidin-1-yl)-5-fluorophenyl)-piperidine-2,6-dione B318; 3-(5-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperidin-1-yl)-2-fluorophenyl)-piperidine-2,6-dione B319; 3-(4-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperidin-1-yl)-3-fluorophenyl)-piperidine-2,6-dione B320; 3-(4-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperidin-1-yl)-2-fluorophenyl)-piperidine-2,6-dione B321; 3-(3-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperidin-1-yl)-2-fluorophenyl)-piperidine-2,6-dione B322; 3-(3-(4-((4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)methyl)-4-fluoropiperidin-1-yl)phenyl)-piperidine-2,6-dione B323; 3-(4-(4-(4-(2-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)oxy)ethyl)piperazin-1-yl)piperidin-1-yl)phenyl)-piperidine-2,6-dione B324; 3-(4-(2-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)ethoxy)phenyl)-piperidine-2,6-dione B351; 3-(4-(4-(((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)methyl)piperidin-1-yl)phenyl)piperidine-2,6-dione B352; 3-(3-(2-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)ethoxy)phenyl)-piperidine-2,6-dione B353; 3-(4-(4-(((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)methyl)-[1,4'-bipiperidin]-1'-yl)phenyl)piperidine-2,6-dione B354; 3-(4-(4-(1-(2-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methyl-cyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)-ethyl)piperidin-4-yl)piperazin-1-yl)phenyl)piperidine-2,6-dione B355; 3-(4-((4-(3-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)phenyl)piperazin-1-yl)methyl)phenyl)piperidine-2,6-dione B356; 3-(4-(4-((4-(3-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methyl-cyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)-phenyl)piperazin-1-yl)methyl)piperidin-1-yl)phenyl)piperidine-2,6-dione B357; 4-(3-(4-((4-(3-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methyl-cyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)-phenyl)piperazin-1-yl)methyl)piperidin-1-yl)phenyl)piperidine-2,6-dione B358; 3-(4-(2-(4-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)piperazin-1-yl)-ethyl)phenyl)piperidine-2,6-dione B359; 3-(4-(4-(4-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)piperazin-1-yl)-piperidin-1-yl)phenyl)piperidine-2,6-dione B360; 3-(3-((1-(3-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)propyl)piperidin-4-yl)oxy)phenyl)-3-methylpiperidine-2,6-dione B361; 3-(4-((1-(3-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)propyl)piperidin-4-yl)oxy)phenyl)-3-methylpiperidine-2,6-dione B362; 3-(3-(4-((3-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)azetidin-1-yl)methyl)-4-fluoropiperidin-1-yl)phenyl)-piperidine-2,6-dione B363; 3-(4-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)azetidin-3-yl)piperazin-1-yl)phenyl)piperidine-2,6-dione B364; 3-(3-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperidin-1-yl)-4-fluorophenyl)-piperidine-2,6-dione B365; 3-(3-(4-((4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-1-yl)methyl)-4-fluoropiperidin-1-yl)phenyl)-3-methylpiperidine-2,6-dione B366; (S)-3-(3-(4-((4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-1-yl)methyl)-4-fluoropiperidin-1-yl)phenyl)-3-methylpiperidine-2,6-dione B367; (S)-3-(4-(2-(1-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)-3-fluoroazetidin-3-yl)ethyl)phenyl)-3-methylpiperidine-2,6-dione B368; (R)-3-(4-(2-(1-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)-3-fluoroazetidin-3-yl)ethyl)phenyl)-3-methylpiperidine-2,6-dione B369; 3-(4-(7-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)-4,7-diazaspiro[2.5]octan-4-yl)phenyl)-piperidine-2,6-dione B370; (R)-3-(4-((R)-2-((4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)methyl)morpholino)phenyl)-3-methylpiperidine-2,6-dione B371; (S)-3-(4-((R)-2-((4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)methyl)morpholino)phenyl)-3-methylpiperidine-2,6-dione B372; (R)-3-(4-((R)-2-((4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-1-yl)methyl)morpholino)phenyl)-3-methylpiperidine-2,6-dione B373; (S)-3-(4-((R)-2-((4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-1-yl)methyl)morpholino)phenyl)-3-methylpiperidine-2,6-dione B374; (R)-3-(4-(4-(((S)-4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)morpholin-2-yl)methyl)piperazin-1-yl)phenyl)-3-methylpiperidine-2,6-dione B375; 1-(4-((1-(3-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)propyl)-piperidin-4-yl)oxy)phenyl)dihydropyrimidine-2,4(1H,3H)-dione B401; 1-(4-(4-(3-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)propyl)piperazin-1-yl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione B402; 1-(2-chloro-4-(4-(3-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)-propyl)piperazin-1-yl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione B403; 1-(4-(4-(3-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)propyl)piperazin-1-yl)-2-fluorophenyl)dihydropyrimidine-2,4(1H,3H)-dione B404; 1-(4-(4-(3-((4-((6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)propyl)piperazin-1-yl)-2-methylphenyl)dihydropyrimidine-2,4(1H,3H)-dione B405; 1-(4-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperidin-1-yl)phenyl)dihydro-pyrimidine-2,4(1H,3H)-dione B406; 1-(4-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione B407; 1-(4-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)-2-fluorophenyl)dihydro-pyrimidine-2,4(1H,3H)-dione B408; 1-(4-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)-2-chlorophenyl)dihydro-pyrimidine-2,4(1H,3H)-dione B409; 1-(4-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)-2-(trifluoromethyl)phenyl)-dihydropyrimidine-2,4(1H,3H)-dione B410; 1-(4-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)-2-methylphenyl)dihydro-pyrimidine-2,4(1H,3H)-dione B411; 1-(4-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)-2,3-dimethylphenyl)dihydro-pyrimidine-2,4(1H,3H)-dione B412; 1-(5-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperidin-1-yl)-2,4-dimethylphenyl)-dihydropyrimidine-2,4(1H,3H)-dione B413; 1-(5-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperidin-1-yl)-2-chloro-3-methyl-phenyl)dihydropyrimidine-2,4(1H,3H)-dione B414; 1-(3-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperidin-1-yl)-5-chloro-2-methyl-phenyl)dihydropyrimidine-2,4(1H,3H)-dione B415; 1-(4-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperazin-1-yl)phenyl)dihydro-pyrimidine-2,4(1H,3H)-dione B416; 1-(4-(4-(1-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)-2-chloro-5-methylphenyl)-dihydropyrimidine-2,4(1H,3H)-dione B451; 1-(4-(4-(1-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)-2-fluoro-3-methylphenyl)-dihydropyrimidine-2,4(1H,3H)-dione B452; 1-(4-(4-(1-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)-2-fluoro-5-methylphenyl)-dihydropyrimidine-2,4(1H,3H)-dione B453; 1-(4-(4-(1-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)-2-chloro-6-methylphenyl)-dihydropyrimidine-2,4(1H,3H)-dione B454; 1-(4-(4-(1-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)-3-fluoro-2-methylphenyl)-dihydropyrimidine-2,4(1H,3H)-dione B455; 1-(3-(4-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperidin-1-yl)phenyl)dihydro-pyrimidine-2,4(1H,3H)-dione B456; 1-(3-(4-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperidin-1-yl)-2-chlorophenyl)-dihydropyrimidine-2,4(1H,3H)-dione B457; 1-(5-(4-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperidin-1-yl)-2-chlorophenyl)-dihydropyrimidine-2,4(1H,3H)-dione B458; 1-(5-(4-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperidin-1-yl)-2-fluorophenyl)-dihydropyrimidine-2,4(1H,3H)-dione B459; 1-(3-(4-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperidin-1-yl)-2-fluorophenyl)-dihydropyrimidine-2,4(1H,3H)-dione B460; 1-(5-(4-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperidin-1-yl)-2-methylphenyl)-dihydropyrimidine-2,4(1H,3H)-dione B461; 1-(3-(4-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperidin-1-yl)-2-methylphenyl)-dihydropyrimidine-2,4(1H,3H)-dione B462; 1-(3-(4-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperidin-1-yl)-2-chloro-6-methyl-phenyl)dihydropyrimidine-2,4(1H,3H)-dione B463; 1-(5-(4-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperidin-1-yl)-4-chloro-2-methyl-phenyl)dihydropyrimidine-2,4(1H,3H)-dione B464; 1-(3-(4-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperidin-1-yl)-2-chloro-4-methyl-phenyl)dihydropyrimidine-2,4(1H,3H)-dione B465; 1-(3-(4-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperidin-1-yl)-4-chloro-2-methyl-phenyl)dihydropyrimidine-2,4(1H,3H)-dione B466; 1-(4-(4-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperidin-1-yl)-2-chlorophenyl)-dihydropyrimidine-2,4(1H,3H)-dione B467; 1-(4-(4-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperazin-1-yl)-2-chlorophenyl)-dihydropyrimidine-2,4(1H,3H)-dione B468; 1-(4-(4-(2-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)ethyl)piperazin-1-yl)phenyl)dihydro-pyrimidine-2,4(1H,3H)-dione B469; 1-(3-(4-((4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)methyl)piperidin-1-yl)phenyl)dihydro-pyrimidine-2,4(1H,3H)-dione B470; 1-(3-(4-((3-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methyl)piperidin-1-yl)-phenyl)dihydropyrimidine-2,4(1H,3H)-dione B471; 1-(4-(2-(1-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)-3-fluoroazetidin-3-yl)ethyl)-2-chloro-phenyl)dihydropyrimidine-2,4(1H,3H)-dione B472; 3-(6-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)-2-oxoethoxy)-1-methyl-1H-indazol-3-yl)-piperidine-2,6-dione B501; 3-(7-(2-(4-(3-((4-((6-(difluoromethyl)-8-((1R,2S)-2-hydroxy-2-methylcyclo-pentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)propyl)-piperazin-1-yl)-2-oxoethoxy)-1-methyl-1H-indazol-3-yl)piperidine-2,6-dione B502; 3-(6-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)-1-methyl-1H-indazol-3-yl)-piperidine-2,6-dione B503; 3-(6-(2-(1-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)-3-fluoroazetidin-3-yl)ethyl)-1-methyl-1H-indazol-3-yl)piperidine-2,6-dione B504; 3-(7-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)-1-methyl-1H-indazol-3-yl)-3-methylpiperidine-2,6-dione B505; 3-(7-(2-(1-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)-3-fluoroazetidin-3-yl)ethyl)-1-methyl-1H-indazol-3-yl)piperidine-2,6-dione B506; 3-(6-(4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)-1-methyl-1H-indazol-3-yl)-piperidine-2,6-dione B507; 3-(6-(4-(2-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)ethyl)piperazin-1-yl)-1-methyl-1H-indazol-3-yl)piperidine-2,6-dione B508; (S)-3-(6-(4-(2-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)ethyl)piperazin-1-yl)-1-methyl-1H-indazol-3-yl)-3-methylpiperidine-2,6-dione B509; (R)-3-(6-(4-(2-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)ethyl)piperazin-1-yl)-1-methyl-1H-indazol-3-yl)-3-methylpiperidine-2,6-dione B510; 3-(6-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperidin-1-yl)-1-methyl-1H-indazol-3-yl)piperidine-2,6-dione B511; 1-(7-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperidin-1-yl)-1-methyl-1H-indazol-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B551; 1-(6-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperidin-1-yl)-1-methyl-1H-indazol-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B552; 1-(7-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)-1-methyl-1H-indazol-3-yl)-dihydropyrimidine-2,4(1H,3H)-dione B553; 1-(6-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)-1-methyl-1H-indazol-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B554; 1-(6-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)-5-fluoro-1-methyl-1H-indazol-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B555; 1-(6-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)-7-fluoro-1-methyl-1H-indazol-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B556; 1-(7-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)-5-fluoro-1-methyl-1H-indazol-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B557; 1-(6-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)-5-chloro-1-methyl-1H-indazol-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B558; 1-(6-(4-(1-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)-7-chloro-1-methyl-1H-indazol-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B559; 1-(7-(4-(1-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)-5-chloro-1-methyl-1H-indazol-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B560; (S)-1-(7-(4-(1-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)-2-methylpiperazin-1-yl)-1-methyl-1H-indazol-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B561; (R)-1-(7-(4-(1-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)-2-methylpiperazin-1-yl)-1-methyl-1H-indazol-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B562; (R)-1-(7-(4-(1-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)-3-methylpiperazin-1-yl)-1-methyl-1H-indazol-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B563; 1-(6-(2-(1-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)-3-fluoroazetidin-3-yl)ethyl)-1-methyl-1H-indazol-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B564; 1-(7-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)-6-chloro-1-methyl-1H-indazol-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B566; 1-(7-(4-((4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-1-yl)methyl)-4-fluoropiperidin-1-yl)-1-methyl-1H-indazol-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B567; (S)-1-(7-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)-3-methylpiperazin-1-yl)-1-methyl-1H-indazol-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B568; 1-(7-(2-(1-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)-3-fluoroazetidin-3-yl)ethyl)-1-methyl-1H-indazol-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B569; 1-(6-(2-(1'-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)-4-fluoro-[1,4'-bipiperidin]-4-yl)ethyl)-1-methyl-1H-indazol-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B570; 1-(7-(2-(1'-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)-4-fluoro-[1,4'-bipiperidin]-4-yl)ethyl)-1-methyl-1H-indazol-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B571; 1-(7-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)-4-chloro-1-methyl-1H-indazol-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B572; 1-(6-(4-(2-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)ethyl)piperazin-1-yl)-1-methyl-1H-indazol-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B573; 1-(6-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethyl)piperidin-1-yl)-1-methyl-1H-indazol-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B574; 1-(6-(4-((4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)methyl)piperidin-1-yl)-1-methyl-1H-indazol-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B575; 3-(5-(1-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)-2-oxoethyl)piperidin-4-yl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione B601; 3-(4-((2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)-2-oxoethyl)amino)-1-oxoisoindolin-2-yl)-piperidine-2,6-dione B602; 4-((2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)-2-oxoethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione B603; or 3-(5-(1-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethoxy)benzyl)piperidin-4-yl)-1-oxo-isoindolin-2-yl)piperidine-2,6-dione B604; : a compound thereof, or an enantiomer, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant thereof; or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.

170. A pharmaceutical composition comprising a compound according to any one of claims 1 to 169, or an enantiomer thereof, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotope variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; and a pharmaceutically acceptable excipient.

171. The pharmaceutical composition according to claim 170, wherein the composition is in a single dosage form.

172. The pharmaceutical composition according to claim 170 or 171, wherein the composition is in an oral, parenteral, or intravenous dosage form.

173. The pharmaceutical composition according to any one of claims 170 to 172, wherein the composition is formulated in an oral dosage form.

174. The pharmaceutical composition according to claim 173, wherein the oral dosage form is a tablet or a capsule.

175. A method of treating, preventing, or ameliorating one or more symptoms of a disorder, disease, or condition mediated by CDK in a subject, the method comprising administering to the subject in need thereof a therapeutically effective amount of a compound according to any one of claims 1 to 169 or a pharmaceutical composition according to any one of claims 170 to 174.

176. The method according to claim 175, wherein the disorder, disease, or condition mediated by CDK is mediated by CDK2, CDK4, and / or CDK6.

177. The method according to claim 175 or 176, wherein the disorder, disease, or condition mediated by CDK is a proliferative disease.

178. A method of treating, preventing, or ameliorating one or more symptoms of a proliferative disease in a subject, the method comprising administering to the subject in need thereof a therapeutically effective amount of a compound according to any one of claims 1 to 169 or a pharmaceutical composition according to any one of claims 170 to 174.

179. The method according to claim 177 or 178, wherein the proliferative disease is cancer.

180. The method according to any one of claims 175 to 179, wherein the subject is human.

181. A method of inhibiting cell proliferation, the method comprising contacting the cell with an effective amount of a compound according to any one of claims 1 to 169 or a pharmaceutical composition according to any one of claims 170 to 174.

182. The method according to claim 181, wherein the cell is a cancer cell.

183. A method for inducing the degradation of CDK, comprising contacting the CDK with an effective amount of the compound according to any one of claims 1 to 169 or the pharmaceutical composition according to any one of claims 170 to 174, said method.

184. The method according to claim 183, wherein the CDK is CDK2, CDK4, and / or CDK6.

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