Cosmetic Composition comprising Ferulic acid as active ingredient
A cosmetic composition combining ferulic acid with a basic amino acid and a pH adjuster addresses the stability and efficacy issues of ferulic acid, maintaining its titer and preventing decomposition and discoloration within a specific pH range.
Patent Information
- Application Number
- JP2024571041
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2022-05-31
- Filing Date
- 2023-05-31
- Publication Date
- 2025-06-12
- Estimated Expiration
- 2043-05-31
AI Technical Summary
Ferulic acid, due to its low solubility and stability issues, faces challenges in cosmetic formulations, including precipitation at pH 5 or lower and decomposition at pH 5 or higher, leading to discoloration, reduced titer, and efficacy.
A cosmetic composition containing ferulic acid, a basic amino acid, and a pH adjuster, with a ferulic acid content of 0.1% or more and a pH range of 4.0 to 6.0, which prevents precipitation, decomposition, and discoloration, thereby maintaining stability and efficacy.
The composition effectively suppresses the decarboxylation decomposition reaction of ferulic acid, maintains its titer even after long-term storage, prevents discoloration and reduction in efficacy, and ensures excellent dosage form stability.
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Abstract
Description
Technical Field
[0001] The present invention relates to a cosmetic composition containing ferulic acid as an active ingredient, and specifically, to a cosmetic composition containing ferulic acid; a basic amino acid; and a pH adjuster.
Background Art
[0002] Ferulic acid exhibits broad antibacterial activity, is efficient in neutralizing active oxygen, and can exhibit various effects as a topical skin agent such as antioxidant, UV cut, and skin whitening effects. Therefore, efforts have been continuously made to develop cosmetics containing ferulic acid.
[0003] However, ferulic acid has very low solubility and low stability, so it could only be used restrictively in cosmetics. Specifically, since the pKa of ferulic acid is 4.61, there is a concern about precipitation at pH 5 or lower, and at pH 5 or higher, ferulic acid is decomposed by the decarboxylation reaction of ferulic acid, resulting in discoloration of the dosage form, reduction in titer, and reduction in the efficacy of ferulic acid.
[0004] Therefore, in order to solve the problem of precipitation of ferulic acid at pH 5 or lower, attempts have been made to add glycols and non-volatile polyols together with ferulic acid to improve solubility and storage stability. However, the content of glycols had to increase in accordance with the content of the contained ferulic acid, and when glycols were used in excess, there was a concern about irritation to the skin.
[0005] In addition, the pH of human skin is 5.5 - 6, but the pKa of ferulic acid is lower than this, and there is also a concern about skin irritation due to this. Therefore, from the perspective of human body safety, there was a need to develop a product that has a pH similar to that of the skin or similar to that of normal cosmetics while using a small amount of polyol.
[0006] At pH 5 or higher, the solubility of ferulic acid is improved, and the amount of polyol used can be reduced, and concerns about skin irritation can be reduced. However, when the pH is 5 or higher, the decarboxylation reaction of ferulic acid occurs, and the composition rapidly changes color, the titer decreases, and the efficacy decreases, which may cause problems in the distribution of cosmetics.
[0007] Conventionally, attempts have been made to improve the dosage form stability of ferulic acid by derivatizing it. However, instead of improving the dosage form stability, these derivatives cannot exhibit the same skin improvement effect as ferulic acid. Therefore, instead of derivatizing ferulic acid, a method that can stably contain ferulic acid itself in a certain content or more was required.
Summary of the Invention
Problems to be Solved by the Invention
[0008] Under the above background, the inventors of the present invention conducted research to improve the stability of ferulic acid. As a result, it was confirmed that when a basic amino acid and a pH adjuster are used in combination with ferulic acid, precipitation of ferulic acid is prevented, the decarboxylation decomposition reaction of ferulic acid is suppressed, and discoloration, decrease in titer, and decrease in efficacy of the composition are prevented, thereby completing the present invention.
[0009] Therefore, an object of the present invention is to provide a cosmetic composition that prevents discoloration, precipitation, decrease in titer, and decrease in efficacy of a composition containing ferulic acid and has excellent dosage form stability.
Means for Solving the Problems
[0010] The present invention provides a cosmetic composition containing ferulic acid; a basic amino acid; and a pH adjuster, wherein the content of the ferulic acid is 0.1% by weight or more based on the weight of the entire composition, and the pH is 4.0 to 6.0.
[0011] In addition, the present invention provides a topical skin preparation containing the above composition.
Effects of the Invention
[0012] The present invention can suppress the decarboxylation decomposition reaction of ferulic acid, maintain the titer of ferulic acid even after long-term storage, prevent discoloration and reduction in efficacy, and thus can provide a composition having excellent dosage form stability.
[0013] At the same time, it can improve the solubility of ferulic acid, reduce concerns about precipitation, and prevent skin irritation.
Brief Description of the Drawings
[0014]
Figure 1
Figure 2
Figure 3
Modes for Carrying Out the Invention
[0015] Hereinafter, the present invention will be described in detail. However, since the present invention can be variously modified and can have various forms, the specific examples and explanations described below are only for helping the understanding of the present invention and do not limit the present invention to a specific disclosed form. The scope of the present invention should be understood to include all modifications, equivalents, or alternatives included in the spirit and technical scope of the present invention.
[0016] "Ferulic acid (ferulic acid or 4-hydroxy-3-methoxycinnamic acid)" of the present invention is a phenolic compound, and its structure is as shown in the following Chemical Formula 1. Ferulic acid can exhibit effects effective for antioxidation, antibacterial effect, whitening effect by suppressing the regeneration of melanin pigment, ultraviolet ray blocking effect, skin elasticity, and prevention of aging.
[0017]
Chemistry
[0018] Ferulic acid has very low solubility in water and is easily oxidized, so it is used restrictively in cosmetics. Therefore, the present invention attempts to provide a cosmetic composition with improved dosage form stability of such ferulic acid.
[0019] The decomposition of ferulic acid begins by a decarboxylation reaction, which is accelerated at pH 5 or higher. The decarboxylation reaction of ferulic acid is shown in the following Reaction Formula 1.
[0020]
Chemistry
[0021] The decarboxylation decomposition reaction of ferulic acid proceeds while the carboxyl functional group of ferulic acid, which is negatively charged in an aqueous solution, forms an ion-pair with other positive charges. If such charge interactions can be suppressed, it is expected that the decomposition of ferulic acid can be suppressed, and therefore, measures are taken to increase the energy required for the decarboxylation decomposition reaction. Considering sodium or potassium ions as the above positive charges, these are not sufficiently ionized in an aqueous solution state and have low binding energy, so they were insufficient to improve the stability of ferulic acid. The inventors of the present invention confirmed that the stability of ferulic acid was improved when using basic amino acids as cationic components after countless attempts, and thus were able to complete the present invention.
[0022] Therefore, the present invention provides a cosmetic composition containing ferulic acid; a basic amino acid; and a pH adjuster.
[0023] In one embodiment of the present invention, the content of ferulic acid may be 0.1% by weight or more based on the weight of the entire composition. Specifically, it may be 0.1 to 10% by weight, more specifically, it may be 0.2% by weight or more, 0.3% by weight or more, 0.5% by weight or more, 0.8% by weight or more, 1% by weight or more, or 2% by weight or more, and may also be 8% by weight or less, 7% by weight or less, 6% by weight or less, 5% by weight or less.
[0024] In one embodiment of the present invention, the basic amino acid may be any basic amino acid known to those skilled in the art. Preferably, the basic amino acid is one or more selected from the group consisting of arginine, lysine, histidine, and carnitine, or their acids or bases, organic or mineral salts. Most preferably, it may be carnitine or arginine. Basic amino acids are harmless to the human body and not only have no concern of skin irritation even when used in large amounts, but also can improve the dosage form stability of ferulic acid. In particular, in addition to basic amino acids, the use of other components having an amine group, such as triethanolamine (TEA) and tromethamine (TRIS), can be considered for the same purpose. However, triethanolamine and tromethamine have risks due to amine unreacted substances (in the case of TEA, N-nitrosodiethanolamine (NDELA); in the case of TRIS, secondary amines). Even if such unreacted substances do not exist at dangerous levels, there may be a problem of skin irritation. Therefore, basic amino acids are more preferred.
[0025] The content of the basic amino acid may vary depending on the content of ferulic acid and the pH adjuster and the pH of the composition, and is not limited as long as it is included together with ferulic acid and the pH adjuster to reach the pH range of the present invention.
[0026] In one embodiment of the present invention, the content of the basic amino acid may be 0.001 to 10% by weight based on the weight of the whole composition. Preferably, it may be 0.001 to 5% by weight, 0.01 to 3% by weight, or 0.01 to 1% by weight. When using the basic amino acid within the content range as described above, the decarboxylation decomposition reaction of ferulic acid can be sufficiently suppressed. However, when used in excess, there is a problem that skin irritation may be induced.
[0027] The pH of the composition may be 4.0 to 6.0. More specifically, the pH may be 4.4 to 6.0, 4.4 to 5.7, more preferably 4.4 to 5.5, 4.4 to 5.3, or 4.4 to 5.2. Such a pH can be adjusted by a pH adjuster. When the pH increases, the solubility of ferulic acid is improved, and the concern of precipitation can be reduced. However, since it may accelerate the decomposition and titer reduction of ferulic acid, it is necessary to adjust the pH within an appropriate range.
[0028] The pH adjuster is a component used to minimize the change in pH and maintain it within a certain range by the conjugate base / conjugate acid action, rather than simply increasing or decreasing the pH like strong acids and strong bases, and it may be a pH buffer.
[0029] Specifically, the pH adjuster may be one or more selected from the group consisting of sodium citrate, potassium citrate, magnesium citrate, salicylic acid, glutamic acid, sodium phosphate, disodium phosphate, potassium phosphate, dipotassium phosphate, calcium phosphate, lactic acid, sulfuric acid, succinic acid, sodium lactate, potassium lactate, calcium lactate, and magnesium lactate. Most preferably, it may be sodium citrate.
[0030] The pH adjuster not only plays a role in adjusting the pH of the composition, but also functional groups such as carboxyl groups, hydroxy groups or amine groups of the pH adjuster interact with ferulic acid (for example, hydrogen bonds or van der Waals forces), and can suppress the decarboxylation decomposition reaction of ferulic acid in the same way as basic amino acids.
[0031] In addition, the pH adjuster can further contain EDTA.
[0032] The content of the pH adjuster may vary depending on the content of ferulic acid and basic amino acids and the pH range of the composition, and there is no limitation as long as it is included together with ferulic acid and basic amino acids to reach the pH of the present invention.
[0033] In one embodiment of the present invention, the content of the pH adjuster may be 0.001 to 3% by weight based on the weight of the whole composition. More specifically, it may be 0.01 to 3% by weight, 0.1 to 2% by weight, or 0.15 to 1.5% by weight. If the pH adjuster is contained less than the above content, it may not be possible to prevent the pH increase due to the decomposition of ferulic acid, and it may accelerate the decomposition and titer reduction of ferulic acid. If it is contained more than the above content, it may affect the quality of the product.
[0034] In the present invention, both the pH adjuster and the basic amino acid can play the role of a pH buffer, and compared with using only a single substance, the influence of ferulic acid by external changes can be reduced.
[0035] In one embodiment of the present invention, the weight ratio of ferulic acid, basic amino acid and pH adjuster may be 1:0.1 to 1.5:0.1 to 1.
[0036] The composition of the present invention can further contain water and / or polyol.
[0037] In one embodiment of the present invention, in order to avoid stickiness and a heavy feeling of use, the content of the polyol may be 20% by weight or less, or even 17.5% by weight or less, based on the weight of the entire composition. Preferably, it may be 1 to 20% by weight, or 2 to 18% by weight, or 5 to 17.5% by weight.
[0038] The polyol may contain one or more of glycerin and glycols. As the glycols, it may be one or more selected from the group consisting of dipropylene glycol, butylene glycol, propanediol, ethoxydiglycol, 2,3 - butanediol, and 1,2 - hexanediol. Preferably, considering the solubility, the polyol may be propanediol and / or ethoxydiglycol.
[0039] The polyol can serve as a humectant and can be used in a sufficient amount for the stabilization of ferulic acid in the dosage form. Otherwise, the problem of precipitation of ferulic acid may occur. In the present invention, the polyol can be used in an amount of about 0.01 to 50 times, 0.05 to 30 times, 0.1 to 20 times, or 3 to 20 times the content of ferulic acid. If the content of the polyol is too high, the problem of inducing skin irritation may occur.
[0040] In one embodiment of the present invention, the content of water may be 50% by weight or more. Specifically, it may be 50 to 90% by weight, and more specifically, it may be 50 to 80% by weight, or 60 to 80% by weight.
[0041] In one embodiment of the present invention, the cosmetic composition of the present invention may not discolor or precipitate, or may maintain its titer even when stored at 50 degrees for 4 weeks.
[0042] In the present invention, "maintaining the titer" means that even when stored at 50 degrees for 4 weeks, ferulic acid is hardly decomposed. Specifically, the degree of decomposition of ferulic acid may be 10% or less, 5% or less, or not decomposed at all.
[0043] The present invention also provides an external preparation for skin containing the above-described cosmetic composition.
[0044] The components contained in the cosmetic composition of the present invention can contain, as active ingredients, components other than the above-mentioned active ingredients, and components usually used in cosmetic compositions. For example, antioxidants, stabilizers, solubilizers, vitamins, ultraviolet absorbers, preservatives, pH adjusters, dyes, pigments, ordinary adjuvants such as fragrances, and carriers and the like can be included.
[0045] The cosmetic composition of the present invention can be produced in any dosage form usually produced in the art. For example, it can be formulated into solutions, suspensions, emulsions, pastes, gels, creams, milky lotions, powders, soaps, cleansing oils, powder foundations, emulsion foundations, wax foundations, packs, massage creams, and sprays, etc., but is not limited thereto. More specifically, it can be produced in the dosage forms of lotions, milky lotions, softening lotions, nutritive lotions, nutritive creams, massage creams, essences, eye creams, cleansing creams, cleansing foams, cleansing waters, packs, sprays, or powders.
[0046] Each of the above-described components contained in the cosmetic composition according to the present invention can preferably be included in the cosmetic composition of the present invention within a range not exceeding the maximum amount of use specified in the regulations related to "Cosmetic Use and Approval" stipulated by each government.
[0047] As another aspect, the present invention provides a method for producing a cosmetic composition containing ferulic acid, including the step of mixing ferulic acid with a basic amino acid and a pH adjuster to produce a cosmetic composition having a pH of 4.0 to 6.0.
[0048] In the above production method, the content of ferulic acid may be 0.1% by weight or more based on the total weight of the composition.
[0049] In the manufacturing method, polyol and / or water can be further mixed.
[0050] In the manufacturing method, after mixing the basic amino acid and the pH adjuster, a step of heating to 40 to 70 degrees can be further included.
[0051] The manufacturing method may be for manufacturing a cosmetic composition in which the precipitation, discoloration, and / or decrease in titer of ferulic acid are substantially absent. Specifically, it may be for manufacturing a cosmetic composition in which the precipitation, discoloration, and / or decrease in titer of ferulic acid are substantially absent even when stored at 50 degrees for 4 weeks.
[0052] In the manufacturing method, for ferulic acid, basic amino acid, pH adjuster, and cosmetic composition, the foregoing content can be applied as it is.
[0053] As another aspect, the present invention provides the use of a basic amino acid and a pH adjuster for manufacturing a cosmetic composition containing ferulic acid in which the precipitation, discoloration, and / or decrease in titer of ferulic acid are substantially absent.
[0054] In the use, for ferulic acid, basic amino acid, pH adjuster, and cosmetic composition, the foregoing content can be applied as it is.
[0055] In the present invention, "substantially absent" can mean that even when stored at 50 degrees for 4 weeks, precipitation, discoloration, and / or decrease in titer of ferulic acid do not occur, or the degree of decomposition of ferulic acid is 10% or less, or 5% or less.
[0056] Hereinafter, the present invention will be described in detail with the following experimental examples. However, the following experimental examples are merely illustrative of the present invention, and the content of the present invention is not limited by the following experimental examples. Also, since these experimental examples are only for the purpose of assisting the understanding of the present invention, in no sense is the scope of the present invention limited by these.
Example
[0057] In this example, the stability of ferulic acid according to pH (Experimental Example 1), the stability of ferulic acid by the cation component used to stabilize ferulic acid (Experimental Example 2), the type of amino acid (Experimental Example 3), and the stability of ferulic acid by the content of the pH adjuster (Experimental Example 4) were confirmed. As a result, as in Experimental Examples 5 and 6, the composition according to the present invention was manufactured, and the dosage form stability and titer analysis were performed.
[0058] <Dosage form stability evaluation> The stability of the dosage form was confirmed for the compositions produced in the following respective experiments. Specifically, the compositions produced in each experiment were stored at 25°C, 50°C, and -15°C for 4 weeks, or stored for 8 hours under exposure conditions where they were exposed to sunlight, and then evaluated according to the following criteria for discoloration and precipitation. 1. Discoloration O: There is no color change or it is hardly recognizable. △: The color change is recognizable, but it does not affect the palatability. X: The color change is so severe that it has an adverse effect on the palatability. 2. Precipitation O: No precipitation X: Precipitation is observed.
[0059] Experimental Example 1. Observation of the stability of ferulic acid according to pH According to the composition in Table 1 below, after heating and mixing at 50°C and then cooling, the compositions of Comparative Examples 1 to 5 having the following compositions were produced.
[0060]
Table 1
[0061] The above <Dosage form stability evaluation> was performed on the produced compositions of Comparative Examples 1 to 5, and the results are shown in Tables 2 and 3.
[0062]
Table 2
[0063]
Table 3
[0064] From Table 3 above, it was confirmed that precipitation occurred under freezing conditions when the pH was low (Comparative Examples 1 and 2), and from Table 2, it was confirmed that discoloration occurred when the pH was high and the sample was exposed to high temperature or light (Comparative Examples 2 to 5). That is, it was confirmed that the decomposition of ferulic acid accelerated with time in a situation where the pH was 4 or higher, and it was necessary to suppress the decomposition of ferulic acid.
[0065] Experimental Example 2. Observation of the stability of ferulic acid by cation components According to the compositions in Table 4 below, after heating and mixing at 50 °C and then cooling, compositions of Comparative Examples 6 to 9 having the following compositions were produced. Appropriate amounts of arginine, tromethamine, NaOH, and KOH were added to adjust the pH to 5.
[0066]
Table 4
[0067] The <dosage form stability evaluation> was performed on the produced compositions of Comparative Examples 6 to 9, and the results are shown in Tables 5 and 6.
[0068]
Table 5
[0069]
Table 6
[0070] As shown in Tables 5 and 6 above, in Comparative Examples 6 to 9, no significant difference was observed in the stability of ferulic acid. However, it was confirmed that slight discoloration occurred at high temperature (50 degrees for 4 weeks). Also, similar to Comparative Example 3, it was confirmed that there was no precipitation under freezing conditions at pH 5 for all of Comparative Examples 6 to 9. Therefore, it was confirmed that basic amino acids can be used as components for stabilizing ferulic acid instead of other dangerous tromethamine and strong bases such as KOH and NaOH.
[0071] Experimental Example 3. Observation of the Stability of Ferulic Acid Depending on the Type of Amino Acid According to the compositions in Table 7 below, after heating and mixing at 50 °C and then cooling, compositions of Comparative Examples 10 to 13 having the following compositions were produced.
[0072] [Table 7]
[0073] The <dosage form stability evaluation> was performed on the produced compositions of Comparative Examples 10 to 13, and the results are shown in Tables 8 and 9.
[0074] [Table 8]
[0075] [Table 9]
[0076] As shown in Tables 8 and 9 above, among the basic amino acids, Comparative Examples 10 and 11 using arginine and carnitine were both confirmed to be excellent in dosage form stability. In Comparative Example 12 using aspartic acid, one of the acidic amino acids, it could not be dissolved during the production process, so the contribution degree of stabilizing ferulic acid could not be confirmed. In Comparative Example 13 using serine, one of the neutral amino acids, even when added in excess, the pH could not be raised to 4 or more, resulting in a problem of precipitation.
[0077] Experimental Example 4. Observation of Stability According to Content of pH Adjusting Agent According to the composition in Table 10 below, after heating and mixing at 50°C and then cooling, compositions of Comparative Examples 14 to 18 having the following compositions were produced.
[0078] [Table 10]
[0079] The <dosage form stability evaluation> was carried out on the produced compositions of Comparative Examples 14 to 18, and the results are shown in Tables 11 and 12.
[0080] [Table 11]
[0081] [Table 12]
[0082] Comparative Examples 14 and 15 containing sodium citrate at 0.1 and 0.2% by weight and having pH values of 4.3 and 4.6, respectively, had ferulic acid precipitated under freezing conditions, while Comparative Examples 16 to 18 containing it at 0.5, 0.8 and 1.0% by weight and having the pH adjusted to 5.2 to 5.7 were confirmed to be stable under freezing conditions. However, Comparative Examples 16 to 18 had a problem that discoloration occurred partially under exposure conditions.
[0083] Experimental Example 5. Observation of Stability of Composition According to the Present Invention According to the composition in Table 13 below, after heating and mixing at 50°C and then cooling, compositions of Examples 1 to 5 having the following compositions were produced.
[0084] [Table 13]
[0085] The <dosage form stability evaluation> was carried out on the compositions of Examples 1 to 5 produced, and the results are shown in Tables 14 and 15.
[0086]
Table 14
[0087]
Table 15
[0088] Based on the results of the amine components and pH adjusters confirmed from Experimental Examples 1 to 4, the composition of this example was manufactured. Although there are slight differences in stability depending on the pH, it can be confirmed that it exhibits excellent dosage form stability overall.
[0089] Experimental Example 6. Observation of the Stability of the Emulsion Dosage Form According to Table 16 below, the aqueous phase (Raw materials 1 to 9) was mixed and heated to 50°C, and the polymer phase (Raw materials 10 to 12) was mixed and maintained at 50°C. Also, the oil phase (Raw materials 13 and 14) was mixed and heated to 50°C. After mixing the aqueous phase and the polymer phase at 5000 rpm for 5 minutes using a homomixer, the oil phase was added and further stirred at 5000 rpm for 5 minutes. Then, it was cooled to 30°C.
[0090]
Table 16
[0091] The <dosage form stability evaluation> was carried out on the compositions of Example 6 and Comparative Example 19 produced in the same manner as above. For the evaluation at temperatures of 25°C, 50°C, and -15°C, discoloration was confirmed after storage for 6 months, and the results are shown in Table 17.
[0092]
Table 17
[0093] It was confirmed that the composition of Example 6 was superior to Comparative Example 19 in terms of dosage form stability. In particular, as shown in Figure 3, as a result of storage at 25°C for 6 months, a clear color difference was observed, which may be directly related to the quality of the product.
[0094] Experimental Example 7. Potency Analysis of Ferulic Acid by pH When Comparative Examples 1, 3, and 5 produced in Experimental Example 1 and Example 3 produced in Experimental Example 5 were stored at 50°C for 4 weeks, it was confirmed how much ferulic acid decreased. That is, ferulic acid at the measurement time point was quantified with respect to the initial content of ferulic acid, and how much ferulic acid decreased was evaluated. The initial values of ferulic acid in Comparative Examples 1, 3, and 5 were 0.3% by weight, and that in Example 3 was 0.5% by weight.
[0095] [Table 18]
[0096] It can be confirmed that in Comparative Examples 1, 3, and 5, when stored at 50°C for 4 weeks, decomposition of ferulic acid occurred, and the decrease in potency was more severe as the pH increased.
[0097] Also, Example 3 had the same pH 5 as Comparative Example 3, but the content of ferulic acid was 0.50% by weight, and since ferulic acid was hardly decomposed, it was confirmed that the potency did not decrease at high temperature and was stably maintained.
[0098] The degree of decrease in ferulic acid was also confirmed for Example 6, which is an emulsion dosage form produced in Experimental Example 6, and Comparative Example 19, and the results are shown in Table 19 below.
[0099] [Table 19]
[0100] As a result of confirming the residual amount of ferulic acid during the change over time at high temperature, it can be confirmed that in Example 6, ferulic acid is not decomposed and is stable, while in Comparative Example 19, decomposition of ferulic acid occurs.
Claims
1. A cosmetic composition comprising ferulic acid, a basic amino acid, and a pH adjuster, wherein the content of the ferulic acid is 0.1% by weight or more based on the weight of the entire composition, and having a pH of 4.0 to 6.
0.
2. The cosmetic composition according to claim 1, wherein the basic amino acid is at least one selected from the group consisting of arginine, lysine, histidine, and carnitine.
3. The cosmetic composition according to claim 1, wherein the content of the basic amino acid is 0.001 to 10% by weight based on the weight of the entire composition.
4. The cosmetic composition according to claim 1, wherein the pH adjuster is at least one selected from the group consisting of sodium citrate, potassium citrate, magnesium citrate, salicylic acid, glutamic acid, sodium phosphate, disodium phosphate, potassium phosphate, dipotassium phosphate, calcium phosphate, lactic acid, sulfuric acid, succinic acid, sodium lactate, potassium lactate, calcium lactate, and magnesium lactate.
5. The cosmetic composition according to claim 1, wherein the content of the pH adjuster is 0.001 to 3% by weight based on the weight of the entire composition.
6. The cosmetic composition according to claim 1, further comprising one or more polyols.
7. The cosmetic composition according to claim 6, wherein the polyol is at least one selected from the group consisting of glycerin, dipropylene glycol, butylene glycol, propanediol, ethoxydiglycol, 2,3 - butanediol, and 1,2 - hexanediol.
8. The cosmetic composition according to claim 1, comprising 50% by weight or more of water based on the weight of the entire composition.
9. The cosmetic composition according to claim 1, characterized in that it does not discolor or precipitate, or the titer is maintained even when stored at 50°C for 4 weeks.
10. An external preparation for skin comprising the cosmetic composition according to any one of claims 1 to 9.
11. A method for producing a cosmetic composition comprising the steps of mixing ferulic acid with a basic amino acid and a pH adjuster to produce a cosmetic composition having a pH of 4.0 to 6.0; A method for producing a cosmetic composition containing ferulic acid.
12. The method for producing a cosmetic composition containing ferulic acid according to claim 11, wherein the production method is for producing a cosmetic composition substantially free of precipitation, discoloration, and / or decrease in titer of ferulic acid.
Citation Information
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