Method for producing a composition comprising a film-coated porous material

Abstract

The present invention relates to a method for producing a composition comprising a film-coated porous material and to the corresponding composition. The present invention further relates to the use of this product in the treatment of the skin for cosmetic purposes and in the treatment of stasis ulcers, split skin grafts, and ulcers.

Description

Technical Field

[0001] The present invention relates to a method for producing a composition comprising a film-coated porous material and to the corresponding composition. The invention further relates to the use of this product in skin treatment for cosmetic purposes and in the treatment of stasis wounds, split skin grafts, and ulcers.

Background Art

[0002] For the purpose of depositing a substance on a substrate, various coating techniques are used, including chemical vapor deposition, physical vapor deposition, electrochemical techniques, spraying, slot die coating, and the like. In particular, coating of conductive substrates such as metals by using electrostatic powder coating technology is well known. In this method, after the powder coating material is charged electrostatically, it is sprayed or sprayed onto the surface of the conductive material, and the powder coating material adheres to this surface. The conductive material is impregnated with the powder by the electrostatic attraction between the positively charged or ionized powder and the negatively charged surface of the conductive material, or by the electrostatic attraction in the reverse case. This method is particularly used for coating metal products.

[0003] Another established technique for applying a solution onto a typical planar substrate is slot die coating. Slot die coating enables a micron-thick layer to be reliably coated onto a flat substrate surface relatively quickly, as shown, for example, in US Patent No. 7097673 (B2). The coating material is typically dissolved or suspended in a solution or slurry and applied onto the surface of the substrate through a precision coating head known as a slot die. Thus, slot die coating is a continuous coating technique that typically delivers low-viscosity materials onto the surface in a quantitatively accurate amount relatively quickly.

[0004] The general use of slot-die coating technology is usually limited to smooth, non-porous materials such as photographic film and paper. An important technical issue related to the coating of porous substrates is how to predict and control the penetration of fluids into the pores, which directly affects the appearance, properties, and performance of the resulting materials. Porous materials are very attractive as controlled drug carriers due to their large surface area, adjustable pore size, and mechanical stability. In particular, porous materials are widely used in medical devices as antibacterial agents, antithrombotic agents, and wound healing agents. However, if a liquid coating containing a healing agent penetrates into the pores uncontrollably, it may have an adverse effect on the healing properties of such devices. Therefore, the stability of the liquid coating on the surface of the porous material is particularly important for local administration devices. In the so-called skin care treatment application, it is important that the time required to wet the porous substrate during liquid uptake is as short as possible, which is measured by the sedimentation time. Therefore, the sedimentation time becomes an important factor for maintaining the porosity of the porous substrate. Also, keeping the pores uncoated is important in medical applications because the pores function as a dermal template on which cells can grow.

[0005] The difference between slot-die coating (a non-contact coating method by which the coating follows the surface shape) and contact coating methods (such as knife coating or roll coating, or any type of printing) is that while slot-die coating lays down a film that is evenly distributed over the porous material, contact coating presses the coating into the substrate. Therefore, the pores are blocked and destroyed by the coating in such a way that the coating penetrates through to the opposite side. SUMMARY OF THE INVENTION

[0006] In one aspect, the present invention is a method for producing a composition comprising a porous material, The porous material is essentially flat and has a pore surface, including a plurality of pores that are open and interconnected. The method comprises: a) providing a porous material, which is essentially flat and has a pore surface, including a plurality of pores that are open and interconnected, the density of the porous material being in the range of 0.01 to 1 g / cm 3 and the pores having an average diameter in the range of 10 to 150 μm; b) providing a coating liquid, the viscosity of the coating liquid being in the range of 1 to 20 Pa·s; c) providing coating means for applying the coating liquid onto the surface of the porous material, the coating means comprising a slot die; d) coating the porous material by applying a quantitative amount of the coating liquid onto the surface of the porous material by relatively moving the porous material and the coating means relative to each other at a speed in the range of 0.1 to 10 m / min to form a liquid layer; e) drying the liquid layer; comprising a method.

[0007] The method according to the invention based on slot die technology mainly enables the surface of the porous material to be covered with a thin film coating that does not penetrate into the remaining pores inside. This effect is achieved by balancing the density of the porous material and the viscosity of the coating liquid to be applied. It has been found that a coating liquid having a viscosity in the range of 1 to 20 Pa·s can be applied to the porous material at an ultra-low density starting from 0.01 g / cm 3 After coating, the density of the porous material increases by 10 to 30%, contributing to maintaining the coating material on the surface of the substrate. At the same time, the porous structure of the porous material is maintained, which is essential for the controlled delivery of the healing agent.

[0008] Furthermore, the method according to the present invention is non-contact, and in particular in step d), the coating means is prevented from contacting the surface of the porous material. Non-contact is achieved by positioning the coating means away from the surface of the porous material. When the contact method is applied, the pores tend to be partially blocked by the coating liquid that penetrates into the pores. In the non-contact method, most of the coating remains on the surface of the porous material and does not penetrate into the pores.

[0009] In another aspect, the present invention relates to a corresponding composition, in particular a composition obtainable by the method according to the present invention.

[0010] In yet another aspect, the present invention relates to the use of a composition comprising a porous material obtainable by the method according to the present invention in cosmetic skin treatments such as the treatment or prevention of wrinkles and skin irritation, and in particular as a medicament for the treatment of stasis wounds, split skin grafts, and ulcers.

[0011] In one aspect, the present invention is a method for producing a composition comprising a porous material, wherein the porous material is essentially flat and has a pore surface, and comprises a plurality of open and interconnected pores, The method comprises: a) providing a porous material, wherein the porous material is essentially flat and has a pore surface, and comprises a plurality of open and interconnected pores, and the density of the porous material is in the range of 0.01 to 1 g / cm 3 preferably in the range of 0.02 to 0.05 g / cm 3 most preferably in the range of 0.02 to 0.04 g / cm 3 and the pores have an average diameter in the range of 10 to 150 μm; b) providing a coating liquid, wherein the viscosity of the coating liquid is in the range of 1 to 20 Pa·s, preferably in the range of 8 to 15 Pa·s, more preferably in the range of 10 to 14 Pa·s; c) A step of providing a coating means for applying the coating liquid onto the surface of the porous material, wherein the coating means includes a slot die; d) A step of coating the porous material by applying a quantitative amount of the coating liquid onto the surface of the porous material by relatively moving the porous material and the coating means relative to each other at a speed within the range of 0.1 to 10 m / min to form a liquid layer; e) A step of drying the liquid layer; including; relating to a method.

[0012] In one embodiment, the density of the porous material increases by 10 to 30%, preferably 10 to 20% after coating, so that the porous substrate of the composition is formed in a method for producing a composition containing the porous material.

[0013] In one embodiment, the quantitative amount of the coating liquid applied onto the surface of the porous material in step d) is within the range of 0.5 to 200 g / m 2 , preferably within the range of 10 to 100 g / m 2 , most preferably within the range of 10 to 30 g / m 2 . In one embodiment, the quantitative amount of the coating liquid applied onto the surface of the porous material in step d) is within the range of 0.5 to 200 g / m 2 . In one embodiment, the quantitative amount of the coating liquid applied onto the surface of the porous material in step d) is within the range of 10 to 100 g / m 2 . In one embodiment, the quantitative amount of the coating liquid applied onto the surface of the porous material in step d) is within the range of 10 to 30 g / m 2 .

[0014] In one embodiment, the thickness of the porous material is within the range of 100 to 5000 μm, preferably within the range of 500 to 3000 μm, more preferably within the range of 1000 to 2000 μm.

[0015] In one embodiment, the thickness of the coating after step e) is in the range of 1 to 300 μm, preferably in the range of 2 to 50 μm, more preferably in the range of 5 to 10 μm.

[0016] In one embodiment, the coating liquid in the method for producing a composition containing a porous material includes a solvent component and a film-forming component. In one embodiment, the solvent component is selected from the group consisting of water, alcohols such as ethanol, and mixtures thereof. In one embodiment, the solvent component is water. In a specific embodiment, the water content in the coating liquid is in the range of 0.5 to 50 wt%, preferably in the range of 2 to 35 wt%, more preferably in the range of 3 to 30 wt%. In one embodiment, the film-forming component is selected from the group consisting of hyaluronic acid (HA); polyacrylate; polyurethane; and polysaccharides such as alginate, nanocellulose, or carboxymethyl cellulose (CMC); or mixtures thereof. In one embodiment, the film-forming component is selected from the group consisting of hyaluronic acid (HA), carboxymethyl cellulose (CMC), polyacrylate, and polyurethane, or mixtures thereof. In one embodiment, the film-forming component is a mixture of hyaluronic acid (HA) and carboxymethyl cellulose (CMC), and the solvent component is water. In one embodiment, the weight ratio of hyaluronic acid (HA) to carboxymethyl cellulose (CMC) in water ranges from 1:3 to 3:1, preferably from 1:2 to 2:1, and most preferably, the weight ratio of hyaluronic acid (HA) to carboxymethyl cellulose (CMC) in water is 1:1. In one embodiment, the coating liquid contains 0.5 to 3 wt% of hyaluronic acid (HA), 0.5 to 3 wt% of carboxymethyl cellulose (CMC), and 94 to 99 wt% of water. In one embodiment, the coating liquid contains approximately 1 wt% of hyaluronic acid (HA), approximately 1 wt% of carboxymethyl cellulose (CMC), and approximately 98 wt% of water.

[0017] In one embodiment, the coating liquid in the method for manufacturing a composition containing a porous material contains an emulsifier. In one embodiment, the emulsifier is selected from the group consisting of polyglyceryl-10 laurate, glycerin, sucrose stearate, methyl glucose sequistearate, glyceryl stearate, cetearyl glucoside, hydrogenated palm fatty acid glycerides, polyethylene glycol, and mixtures thereof.

[0018] In one embodiment, the coating liquid in the method for manufacturing a composition containing a porous material contains additional components selected from the group consisting of vitamin A, vitamin B, vitamin C, vitamin D, vitamin K, vitamin E, and 4-[(1E,3S)-3-ethenyl-3,7-dimethylocta-1,6-dienyl]phenol (bacteriol), or mixtures thereof. Preferably, the additional component is vitamin D.

[0019] In one embodiment, the porous material in the method for manufacturing a composition containing takes the form of a sheet, a bandage, or a roll sheet. The roll sheet is an advantageous form in a continuous operation mode of coating the porous material with the coating liquid.

[0020] The porous material in the method of manufacturing the composition is essentially flat, that is, the thickness of the porous material does not deviate by more than ±20%, preferably ±10% from the average thickness of the material over the entire length and width of the material. Thus, the porous substrate in the composition has two main surfaces from the upper and lower sides (see Fig. 23), which face in opposite directions and extend over the entire length and width of the substrate. For example, when the average thickness is 1 mm, the thickness of the material over the entire length and width is maintained within the range of 0.8 - 1.2 mm, preferably within the range of 0.9 - 1.1 mm. When the average thickness is 2 mm, the thickness of the essentially flat material over the entire length and width is maintained within the range of 1.6 - 2.4 mm, preferably within the range of 1.8 - 2.2 mm. In one embodiment, the porous material and the porous substrate are flat.

[0021] In one embodiment, the porous material in the method of manufacturing a composition comprising a porous material comprises at least 90% by weight of biomaterial, preferably the porous material comprises at least 95% by weight of biomaterial, more preferably the porous material comprises at least 98% by weight of biomaterial, and most preferably the porous material comprises at least 99% by weight of biomaterial.

[0022] In one embodiment, the density of the porous material in the method of manufacturing a composition comprising a porous material is in the range of 0.01 - 1 g / cm 3 and preferably in the range of 0.02 - 0.05 g / cm 3 and more preferably in the range of 0.02 - 0.04 g / cm 3 and most preferably in the range of 0.022 - 0.03 g / cm 3 and is within the range.

[0023] In one embodiment, the pores of the porous material in the method for manufacturing a composition containing the porous material have an average diameter in the range of 10 to 150 μm. In one embodiment, the pores of the porous material in the method for manufacturing a composition containing the porous material have an average diameter in the range of 15 to 65 μm. In one embodiment, the pores of the porous material in the method for manufacturing a composition containing the porous material have an average diameter in the range of 15 to 40 μm. In one embodiment, the pores of the porous material in the method for manufacturing a composition containing the porous material have an average diameter in the range of 25 to 100 μm.

[0024] In one embodiment, the viscosity of the coating liquid in the method for manufacturing a composition containing the porous material is in the range of 1 to 20 Pa·s. In a preferred embodiment, the viscosity of the coating liquid in the method for manufacturing a composition containing the porous material is in the range of 5 to 20 Pa·s. In a more preferred embodiment, the viscosity of the coating liquid in the method for manufacturing a composition containing the porous material is in the range of 8 to 15 Pa·s. In an even more preferred embodiment, the viscosity of the coating liquid in the method for manufacturing a composition containing the porous material is in the range of 10 to 14 Pa·s.

[0025] In one embodiment, the porous material in the method for manufacturing a composition containing the porous material has a density in the range of 0.01 to 1 g / cm 3 and the viscosity of the coating liquid is in the range of 1 to 20 Pa·s. In a preferred embodiment, the porous material in the method for manufacturing the composition has a density in the range of 0.02 to 0.05 g / cm 3 and the viscosity of the coating liquid is in the range of 8 to 15 Pa·s. In a more preferred embodiment, the porous material in the method for manufacturing the composition has a density in the range of 0.02 to 0.04 g / cm 3 and the viscosity of the coating liquid is in the range of 10 to 14 Pa·s.

[0026] In one embodiment, the porous material in the method for manufacturing a composition containing the porous material is a biomaterial.

[0027] The material is selected from the group comprising natural and / or synthetic polymers or mixtures thereof, in particular polysaccharides, glucosaminoglycans, proteins, or mixtures thereof.

[0028] In one embodiment, the porous material in a method for producing a composition comprising a porous material is selected from the group consisting of collagen; alginates, such as calcium alginate; hyaluronic acid; cellulose; and vegetable proteins, such as pea and soybean; or mixtures thereof.

[0029] In one embodiment, the porous material in a method for producing a composition comprising a porous material is collagen. In one embodiment, the porous material in a method for producing a composition comprising a porous material is an alginate, in particular calcium alginate.

[0030] In one embodiment, the porous material in a method for producing a composition comprising a porous material is a mixture of collagen and calcium alginate. In one embodiment, the porous material comprises collagen in the range of 80 to 98% by weight and calcium alginate in the range of 2 to 20% by weight. In a preferred embodiment, the porous material comprises collagen in the range of 85 to 95% by weight and calcium alginate in the range of 5 to 15% by weight. In particular, the porous material comprises about 90% by weight of collagen and about 10% by weight of calcium alginate.

[0031] In one embodiment, the collagen in the porous material in a method for producing a composition comprising a porous material is natural animal-derived collagen having a triple helix structure.

[0032] In one embodiment, the collagen in the porous material in a method for producing a composition comprising a porous material is selected from the group comprising type I collagen, type III collagen, type V collagen, or mixtures thereof.

[0033] In one embodiment of a method for producing a composition comprising a porous material, the application of a coating liquid onto the surface of the porous material is carried out such that the porous material is positioned under a fixed slot die and moves horizontally under the slot die. In one embodiment, the speed at which the porous material is moved is in the range of 0.1 to 10 m / min.

[0034] In one embodiment of a method for producing a composition comprising a porous material, the distance between the slot die and the surface of the porous material is at least 50 μm, preferably at least 100 μm, more preferably at least 200 μm.

[0035] In one embodiment of a method for producing a composition comprising a porous material, the distance between the slot die and the surface of the porous material is in the range of 50 to 1000 μm, preferably 100 to 800 μm, more preferably 200 to 600 μm.

[0036] In one embodiment of a method for producing a composition comprising a porous material, the solvent component of the coating liquid is water, and the drying in step e) is carried out such that the final water content in the dried composition is in the range of 5 to 25 wt%, preferably in the range of 10 to 18 wt%.

[0037] In one embodiment of a method for producing a composition comprising a porous material, the drying in step e) is carried out by sending hot air to the liquid layer, and the temperature of the hot air is in the range of 30 to 100 °C, preferably in the range of 35 to 50 °C. In another aspect, the present invention relates to a composition comprising a porous material obtainable by the method according to any of the above embodiments.

[0038] In a third aspect, the present invention relates to a composition comprising a porous material obtainable by the method according to any of the above embodiments for use as a medicament. In one embodiment, the present invention relates to a composition comprising a porous material obtainable by the method according to any of the above embodiments for use in the treatment of stagnant wounds, split skin grafts, and ulcers.

[0039] In a fourth aspect, the present invention relates to a composition comprising a porous material obtainable by the method according to any of the above embodiments for use in cosmetic skin treatment. In one embodiment, the present invention relates to a composition comprising a porous material obtainable by the method according to any of the above embodiments for use in the treatment or prevention of wrinkles and skin irritation.

[0040] In a fifth aspect, the present invention relates to the use of a composition comprising a porous material obtainable by the method according to any of the above embodiments in the treatment of stagnant wounds, split skin grafts, and ulcers.

[0041] In a sixth aspect, the present invention relates to the use of a composition comprising a porous material obtainable by the method according to any of the above embodiments in cosmetic skin treatment such as the treatment or prevention of wrinkles and skin irritation.

[0042] In a seventh aspect, the present invention relates to a method for treating stagnant wounds, split skin grafts, and ulcers, comprising administering to a subject in need of treatment of stagnant wounds, split skin grafts, and ulcers a composition comprising a porous material obtainable by the method according to any of the above embodiments.

[0043] In an eighth aspect, the present invention is A porous substrate comprising a first major surface and a second major surface, the porous substrate being essentially flat and comprising a plurality of open and interconnected pores, the pore surfaces extending through the substrate from the first major surface to the second major surface, the pores having an average diameter in the range of 10 to 150 μm; A coating on the first major surface and / or the second major surface, comprising hyaluronic acid (HA); polyacrylate; polyurethane; or a polysaccharide such as alginate, nanocellulose, or carboxymethylcellulose (CMC); or a mixture thereof; A composition comprising The composition is characterized by having a water absorption capacity in the range of 10 to 50 g, preferably in the range of 20 to 40 g, per 1 g of the composition. Relates to a composition. In one embodiment, the thickness of the porous substrate is in the range of 1 to 5 mm, preferably in the range of 1 to 3 mm, more preferably in the range of 1 to 2 mm, and the composition has a water absorption capacity in the range of 20 to 40 g per 1 g of the composition. In one embodiment, the composition has a water absorption capacity that does not deviate by more than ±50%, preferably more than ±40%, more preferably more than ±30%, and most preferably more than ±20% from the water absorption capacity of the uncoated porous substrate, preferably collagen.

[0044] In a preferred embodiment, the composition has a water absorption capacity in the range of 25 to 35 g per 1 g of the composition.

[0045] In one embodiment, the thickness of the porous substrate is in the range of 1 mm to 2 mm, and the composition has a water absorption capacity in the range of 25 to 35 g per 1 g of the composition.

[0046] In one embodiment, the coating in the composition is bonded via non-covalent bonds to the first major surface of the porous substrate and / or the second major surface.

[0047] In one embodiment, the composition does not contain a cross-linking agent that binds the porous substrate and the coating.

[0048] In some embodiments, the coating on the first major surface and / or the second major surface of the porous substrate further contains water and / or an alcohol such as ethanol. In some embodiments, the coating on the first major surface and / or the second major surface contains water.

[0049] In a preferred embodiment, the coating contains hyaluronic acid (HA), carboxymethyl cellulose (CMC), and water.

[0050] In some embodiments, the amount of the coating in the composition is in the range of 0.1 to 10 wt%, preferably in the range of 0.5 to 3 wt%, based on the weight of the substrate.

[0051] In some embodiments, at least 80%, preferably at least 90%, more preferably at least 95%, and most preferably at least 99% of the first major surface and / or the second major surface is coated with the coating.

[0052] In some embodiments, the second major surface of the porous substrate does not include the coating. In one embodiment, the coating on the first major surface and / or the second major surface of the porous substrate further includes an emulsifier. In one embodiment, the emulsifier is selected from the group consisting of polyglyceryl-10 laurate, glycerin, sucrose stearate, methyl glucose sequistearate, glyceryl stearate, cetearyl glucoside, hydrogenated palm fatty acid glycerides, polyethylene glycol, and mixtures thereof.

[0053] In one embodiment, the coating on the first major surface and / or the second major surface of the porous substrate further includes a component selected from the group consisting of vitamin A, vitamin B, vitamin C, vitamin D, vitamin K, vitamin E, and 4-[(1E,3S)-3-ethenyl-3,7-dimethylocta-1,6-dienyl]phenol (bactiothiol), or mixtures thereof. Preferably, the additional component is vitamin D.

[0054] In one embodiment, the porous substrate in the composition includes at least 90 wt% of a biomaterial, preferably the porous substrate includes at least 95 wt% of a biomaterial, more preferably the porous substrate includes at least 98 wt% of a biomaterial, and most preferably the porous substrate includes at least 99 wt% of a biomaterial.

[0055] In one embodiment, the pores in the porous substrate of the composition have an average diameter in the range of 10 to 150 μm. In one embodiment, the pores in the porous substrate of the composition have an average diameter in the range of 15 to 65 μm. In one embodiment, the pores in the porous substrate of the composition have an average diameter in the range of 15 to 40 μm. In one embodiment, the pores in the porous substrate of the composition have an average diameter in the range of 25 to 100 μm.

[0056] In one embodiment, the porous substrate in the composition is a biomaterial.

[0057] In one embodiment, the porous substrate in the composition is selected from the group consisting of natural and / or synthetic polymers or mixtures thereof, particularly polysaccharides, glucosaminoglycans, proteins, or mixtures thereof.

[0058] In one embodiment, the porous substrate in the composition is selected from the group consisting of collagen; alginates, such as calcium alginate; hyaluronic acid; cellulose; and vegetable proteins, such as pea and soybean; or mixtures thereof.

[0059] In one embodiment, the porous substrate in the composition is collagen. In one embodiment, the porous substrate in the composition is an alginate, particularly calcium alginate.

[0060] In one embodiment, the porous substrate in the composition is a mixture of collagen and calcium alginate. In one embodiment, the porous substrate comprises collagen in the range of 80 to 98% by weight and calcium alginate in the range of 2 to 20% by weight. In a preferred embodiment, the porous substrate comprises collagen in the range of 85 to 95% by weight and calcium alginate in the range of 5 to 15% by weight. In particular, the porous substrate comprises about 90% by weight of collagen and about 10% by weight of calcium alginate.

[0061] In one embodiment, the collagen in the porous substrate is natural collagen derived from animals having a triple helix structure.

[0062] In one embodiment, the collagen in the porous substrate is selected from the group consisting of type I collagen, type III collagen, type V collagen, or a mixture thereof.

[0063] In some embodiments, the method according to any of the above embodiments is used to prepare the composition as defined in any of the above embodiments.

[0064] In a ninth aspect, the present invention relates to a composition according to any of the above embodiments for cosmetic skin treatment. In one embodiment, the present invention relates to a composition according to any of the above embodiments for use in the treatment or prevention of wrinkles and skin irritation.

[0065] In a tenth aspect, the present invention relates to the use of a composition according to any of the above embodiments in the treatment of stagnant wounds, split skin grafts, and ulcers.

[0066] In an eleventh aspect, the present invention relates to the use of a composition according to any of the above embodiments in cosmetic skin treatment such as the treatment or prevention of wrinkles and skin irritation.

[0067] In a twelfth aspect, the present invention relates to a method for treating stagnant wounds, split skin grafts, and ulcers, comprising administering a composition according to any of the above embodiments to a subject in need of treatment for stagnant wounds, split skin grafts, and ulcers. BRIEF DESCRIPTION OF THE DRAWINGS

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Mode for Carrying Out the Invention

[0069] Based on the above background, the following embodiments with consecutive numbers provide further specific aspects of the present invention.

[0070] Embodiment 1 A method for manufacturing a composition containing a porous material, wherein the porous material is essentially flat and has a pore surface, and includes a plurality of pores that are open and interconnected, the method comprising: a) a step of providing a porous material, wherein the porous material is essentially flat and has a pore surface, and includes a plurality of pores that are open and interconnected, and the density of the porous material is in the range of 0.01 - 1 g / cm 3 preferably in the range of 0.02 - 0.05 g / cm 3 most preferably in the range of 0.02 - 0.04 g / cm 3 and the pores have an average diameter in the range of 10 - 150 μm; b) A step of providing a coating liquid, wherein the viscosity of the coating liquid is in the range of 1 to 20 Pa·s, preferably in the range of 5 to 20 Pa·s, more preferably in the range of 8 to 15 Pa·s, and even more preferably in the range of 10 to 14 Pa·s; c) A step of providing a coating means for applying the coating liquid onto the surface of the porous material, wherein the coating means comprises a slot die; d) A step of coating the porous material by applying a quantitative amount of the coating liquid onto the surface of the porous material by relatively moving the porous material and the coating means relative to each other at a speed in the range of 0.1 to 10 m / min, thereby forming a liquid layer; e) A step of drying the liquid layer; comprising; Method.

[0071] Embodiment 2 A method for producing a composition comprising the porous material according to Embodiment 1, wherein the density of the porous material increases by 10 to 30%, preferably 10 to 20% after coating.

[0072] Embodiment 3 The quantitative amount of the coating liquid applied onto the surface of the porous material in step d) is in the range of 0.5 to 200 g / m 2 preferably in the range of 10 to 100 g / m 2 most preferably in the range of 10 to 30 g / m 2 A method for producing a composition comprising the porous material according to Embodiment 1 or Embodiment 2.

[0073] Embodiment 4 A method for producing a composition comprising the porous material according to any one of Embodiments 1 to 3, wherein the coating liquid comprises a solvent component and a film-forming component.

[0074] Embodiment 5 A method for producing a composition comprising the porous material according to Embodiment 4, wherein the solvent component is water.

[0075] Embodiment 6 A method for producing a composition containing the porous material according to Embodiment 5, wherein the water content in the coating liquid is in the range of 0.5 to 50 wt%, preferably in the range of 2 to 35 wt%, more preferably in the range of 3 to 30 wt%.

[0076] Embodiment 7 A method for producing a composition containing the porous material according to any one of Embodiments 4 to 6, wherein the film-forming component is selected from the group consisting of hyaluronic acid (HA); polyacrylate; polyurethane; and polysaccharides such as alginate, nanocellulose, or carboxymethylcellulose (CMC); or a mixture thereof.

[0077] Embodiment 8 A method for producing a composition containing the porous material according to any one of Embodiments 1 to 7, wherein the coating liquid is an emulsifier.

[0078] Embodiment 9 A method for producing a composition containing the porous material according to Embodiment 8, wherein the emulsifier is selected from the group consisting of polyglyceryl-10 laurate, glycerin, sucrose stearate, methyl glucose sequistearate, glyceryl stearate, cetearyl glucoside, hydrogenated palm fatty acid glycerides, polyethylene glycol, or a mixture thereof.

[0079] Embodiment 10 A method for producing a composition containing the porous material according to any one of Embodiments 1 to 9, wherein the coating liquid contains a further component selected from the group consisting of vitamin A, vitamin B, vitamin C, vitamin K, vitamin E, and 4-[(1E,3S)-3-ethenyl-3,7-dimethylocta-1,6-dienyl]phenol (bactiol), or a mixture thereof.

[0080] Embodiment 11 A method for producing a composition comprising the porous material according to any one of Embodiments 1 to 10, wherein the porous material is a biomaterial.

[0081] Embodiment 12 A method for producing a composition comprising the porous material according to Embodiment 11, wherein the biomaterial is selected from the group consisting of natural and / or synthetic polymers or mixtures thereof, particularly polysaccharides, glucosaminoglycans, proteins, and / or synthetic polymers, or mixtures thereof.

[0082] Embodiment 13 A method for producing a composition comprising the porous material according to Embodiment 11 or Embodiment 12, wherein the biomaterial is selected from the group consisting of collagen; alginate; hyaluronic acid; cellulose; and vegetable proteins such as pea and soybean.

[0083] Embodiment 14 A method for producing a composition comprising the porous material according to Embodiment 13, wherein the biomaterial is collagen.

[0084] Embodiment 15 A method for producing a composition comprising the porous material according to Embodiment 14, wherein the biomaterial is a natural collagen of animal origin having a triple helix structure.

[0085] Embodiment 16 A method for producing a composition comprising the porous material according to any one of Embodiments 1 to 15, wherein the porous material is positioned under a fixed slot die, and a coating liquid is applied onto the surface of the porous material so as to move horizontally under the slot die.

[0086] Embodiment 17 A method for producing a composition comprising the porous material according to any one of Embodiments 1 to 16, wherein the distance between the slot die and the surface of the porous material is in the range of 50 to 1000 μm, preferably 100 to 800 μm, more preferably 200 to 600 μm.

[0087] Embodiment 18 [A method for producing a composition comprising the porous material according to any one of Embodiments 1 to 17, wherein drying in step e) is performed by sending hot air to the liquid layer, and the temperature of the hot air is in the range of 30 to 100°C, preferably in the range of 35 to 50°C.]

[0088] Embodiment 19 [A method for producing a composition comprising the porous material according to any one of Embodiments 1 to 18, wherein the porous material is in the form of a sheet, a dressing, or a roll sheet.]

[0089] Embodiment 20 A porous substrate comprising a first major surface and a second major surface, wherein the porous substrate is essentially flat and includes a plurality of open and interconnected pores, and the pore surface extends through the porous substrate from the first major surface to the second major surface, and the pores have an average diameter in the range of 10 to 150 μm; A coating on the first major surface and / or the second major surface of the porous substrate, comprising hyaluronic acid (HA); polyacrylate; polyurethane; or a polysaccharide such as alginate, nanocellulose, or carboxymethylcellulose (CMC); or a mixture thereof; A composition comprising: The composition is characterized in that it has a water absorption in the range of 10 to 50 g, preferably in the range of 20 to 40 g, per 1 g of the composition. Composition.

[0090] Embodiment 21 The composition according to Embodiment 20, wherein the coating in the composition is bonded to the first major surface and / or the second major surface of the porous substrate via non-covalent bonds.

[0091] Embodiment 22 The composition according to Embodiment 20 or Embodiment 21, which does not contain a cross-linking agent for binding the porous substrate and the coating.

[0092] Embodiment 23 The composition according to any one of Embodiments 20 to 22, wherein the coating on the first major surface and / or the second major surface further contains water.

[0093] Embodiment 24 The composition according to any one of Embodiments 20 to 23, wherein the amount of the coating in the composition is in the range of 0.1 to 10 wt%, preferably in the range of 0.5 to 3 wt%, based on the weight of the composition.

[0094] Embodiment 25 The composition according to any one of Embodiments 20 to 24, wherein at least 80%, preferably at least 90%, more preferably at least 95%, and most preferably at least 99% of the first major surface and / or the second major surface of the porous substrate is coated with the coating.

[0095] Embodiment 26 The composition according to any one of Embodiments 20 to 25, wherein the coating on the first major surface and / or the second major surface of the porous substrate further contains an emulsifier.

[0096] Embodiment 27 The composition according to any one of Embodiments 20 to 26, wherein the coating on the first major surface and / or the second major surface of the porous substrate further contains a component selected from the group consisting of vitamin A, vitamin B, vitamin C, vitamin D, vitamin K, vitamin E, and 4-[(1E,3S)-3-ethenyl-3,7-dimethylocta-1,6-dienyl]phenol (bacteriol), or a mixture thereof.

[0097] Embodiment 28 The composition according to any one of Embodiments 20 to 27, wherein the porous substrate in the composition contains at least 90% by weight of a biomaterial, preferably at least 95% by weight of a biomaterial, more preferably at least 98% by weight of a biomaterial, and most preferably at least 99% by weight of a biomaterial.

[0098] Embodiment 29 The composition according to any one of Embodiments 20 to 28, wherein the porous substrate in the composition is a biomaterial.

[0099] Embodiment 30 The composition according to any one of Embodiments 20 to 29, wherein the porous substrate in the composition is selected from the group consisting of natural and / or synthetic polymers or mixtures thereof, particularly polysaccharides, glucosaminoglycans, proteins, or mixtures thereof.

[0100] Embodiment 31 The composition according to any one of Embodiments 20 to 30, wherein the porous substrate in the composition is selected from the group consisting of collagen; alginates such as calcium alginate; hyaluronic acid; cellulose; and vegetable proteins such as pea and soybean; or mixtures thereof.

[0101] Embodiment 32 The composition according to Embodiment 31, wherein the porous substrate in the composition is collagen.

[0102] Embodiment 33 The composition according to Embodiment 31 or Embodiment 32, wherein the porous substrate in the composition is a mixture of collagen and calcium alginate.

[0103] Embodiment 34 The composition according to any one of Embodiments 31 to 33, wherein the collagen in the porous substrate is natural collagen derived from animals having a triple helix structure.

[0104] Embodiment 35 The composition according to any one of Embodiments 31 to 34, wherein the collagen in the porous substrate is selected from the group consisting of type I collagen, type III collagen, type V collagen, or mixtures thereof.

[0105] Embodiment 36 A composition obtainable by the method according to any one of Embodiments 1 to 19.

[0106] Embodiment 37 The composition according to any one of Embodiments 20 to 36 for use as a medicament.

[0107] Embodiment 38 The composition according to any one of Embodiments 20 to 36 for use in the treatment of stasis wounds, split skin grafts, and ulcers.

[0108] Embodiment 39 The composition according to any one of Embodiments 20 to 36 for use in cosmetic skin treatments such as the treatment or prevention of wrinkles and skin irritation.

[0109] Embodiment 40 Use of the composition according to any one of Embodiments 20 to 36 in the treatment of stasis wounds, split skin grafts, and ulcers.

[0110] Embodiment 41 Use of the composition according to any one of Embodiments 20 to 36 in cosmetic skin treatments such as the treatment or prevention of wrinkles and skin irritation.

[0111] Embodiment 42 A method for treating stasis wounds, split skin grafts, and ulcers, comprising administering to a subject in need of treatment for stasis wounds, split skin grafts, and ulcers the composition according to any one of Embodiments 20 to 36.

[0112] Definition The definitions of various terms used in the description of the present invention are shown below. These definitions apply to the terms used throughout this specification and the claims, individually or as part of a larger group, unless otherwise limited in a particular case. Unless otherwise defined, all technical and scientific terms used in this specification have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. As used in this specification, the articles "a" and "an" refer to the grammatical object of the article being one or more than one (i.e., at least one). By way of example, "an element" means at least one element, i.e., one element or more than one element.

[0113] As used in this specification, the term "porous material" refers to a material having pores, i.e., voids, channels, or gaps, where the depth of the pores exceeds their average diameter.

[0114] As used in this specification, the term "porous substrate" refers to the porous material of the composition onto which a coating is applied. Unless specifically defined otherwise, the term "thickness" with respect to a porous material refers to the average thickness of the porous material.

[0115] As used in this specification, the term "substantially flat" refers to a material having a thickness that does not deviate by more than ±20%, preferably more than ±10%, from the average thickness over the entire length and width.

[0116] As used in this specification, the term "sheet" refers to a substantially flat material having a thickness within the range of 1 to 8 mm.

[0117] As used in this specification, the terms "roll material" and "roll sheet" are used synonymously and refer to a sheet of porous material wound cylindrically around the central axis of a roll, where the material is removable from the central or inner peripheral part of the roll.

[0118] As used herein, the term "bandage" refers to a composition comprising a porous material that is film-coated and further coated with an additional polymer layer, wherein the composition is in the form of a sheet.

[0119] As used herein, the term "coating means" refers to means suitable for applying a liquid onto the surface of a material.

[0120] As used herein, the term "solvent component" refers to a liquid composed of a single solvent or a mixture of solvents, which is suitable for solubilizing or dispersing one or more of various substances. Non-limiting examples of such solvents include water and alcohols such as ethanol or isopropanol.

[0121] As used herein, the term "film-forming component" refers to a substance capable of forming a film when applied to a solid surface. In particular, the film-forming component is applied to the surface in the form of a liquid layer, and a film is formed after air-drying of the liquid layer. Non-limiting examples of the film-forming component include hyaluronic acid (HA), carboxymethyl cellulose (CMC), nanocellulose, alginate, polyacrylate, and polyurethane.

[0122] As used herein, the term "emulsifier" refers to a substance that promotes the mixing of immiscible liquids with different polarities (e.g., water and lipophilic components). Non-limiting examples of the emulsifier include polyglyceryl-10 laurate, polyglyceryl-10 laurate, glycerin, sucrose stearate, methyl glucose sequistearate, glyceryl stearate, cetearyl glucoside, hydrogenated palm fatty acid glyceride, and polyethylene glycol.

[0123] As used herein, the term "coating" refers to a thin deposit of a substance that substantially covers the surface of a substrate.

[0124] As used herein, the term "salt" refers to an ionic chemical substance consisting of a positively charged cation and a negatively charged anion aggregated by an ionic bond.

[0125] As used herein, the term "biomaterial" refers to a natural or synthetic biocompatible material suitable for use in medical devices intended to interact with biological systems. Non-limiting examples include polysaccharides such as collagen; gelatin; alginate; and glycosaminoglycan.

[0126] As used herein, the term "polysaccharide" refers to a polymer containing a backbone mainly (at least 90%) composed of monosaccharide repeating units and / or derivatized monosaccharide repeating units.

[0127] As used herein, the term "protein" or "polypeptide" refers to a polymer of two or more natural or unnatural amino acids.

[0128] As used herein, the term "glycosaminoglycan" refers to a group of acidic polysaccharides each having a repeating unit of a disaccharide composed of an amino sugar and uronic acid or galactose.

[0129] As used herein, the term "alginate" refers to the anion of alginic acid. Thus, the terms "alginate" and "alginate salt" are used interchangeably in the context of the present invention. The alginate can be, for example, calcium alginate. Alginate is a linear polymer formed by the anions of β-D-mannuronic acid (M, β-D-mannuronate) and α-L-guluronic acid (G, α-L-guluronate) linked by 1-4 glycosidic bonds.

[0130] As used herein, the term "collagen" refers to a family of extracellular fibrous proteins characterized by a rigid triple helix structure. This helical molecule is formed by the twisting together of three collagen polypeptide chains ("α-chains").

[0131] As used herein, the term "subject" refers to a human or non-human mammal. Preferably, the subject is a human.

Examples

[0132] Example 1 Coating solution 1 CMC (carboxymethyl cellulose): 3.3 wt% Water: 96.7 wt% Coating solution 2 Vitamin C: 25 wt% CMC (carboxymethyl cellulose): 3.3 wt% Water: 71.7 wt% Coating solution 3 4-[(1E,3S)-3-ethenyl-3,7-dimethylocta-1,6-dienyl]phenol (bactiol): 5 wt% Polyglyceryl-10 laurate: 5 wt% CMC (carboxymethyl cellulose): 4 wt% Water: 86 wt%

[0133] Coating procedure: The coating was applied by the slot-die method. A schematic diagram of this method is shown in Figure 1. The series of process steps are as follows: Place a porous collagen matrix substrate having dimensions of 46×33×0.15 cm and a density of 0.022 g / cm 3 on a movable stage. Position the slot-die at a distance of 700 μm from the surface of the substrate. Configure the stage to move horizontally at a speed of 1 m / min under the slot-die. Once the slot die reaches a position above the substrate, configure the pump to deliver the coating liquid at a flow rate of 5 ml / min. After the coating has spread evenly over the substrate, turn off the pump switch. By drying the applied coating in an oven at 90 °C for 2 minutes, a thin coating film is formed on the substrate. SEM images of the uncoated collagen matrix and the collagen matrix coated with CMC (coating liquid 1) are shown in Figures 2 and 3 respectively.

[0134] Example 2 To clarify the advantageous properties of the products produced by the method according to the present invention, a series of comparative experiments were conducted. The results are summarized in Table 1.

[0135] Using the non-contact slot die method, a 1.1% HA coating aqueous solution having a viscosity of 11.8 Pa·S (measured with a viscometer) was applied at thicknesses of 20 μm (Experiment 1) and 40 μm (Experiment 2) to coat the porous collagen matrix as described in the following procedure 2a:

[0136] Procedure 2a Place a porous collagen matrix substrate having dimensions of 460 mm × 330 mm × 1.5 mm and a density of 0.024 g / cm 3 on a movable stage. Position the slot die at a distance of 350 μm (for 20 μm) and 700 μm (for 40 μm) from the surface of the substrate. Configure the stage to move horizontally at a speed of 1 m / min under the slot die. Once the slot die reaches a position above the substrate, configure the pump to deliver the 1.1% HA coating aqueous solution at a flow rate of 6.3 ml / min to form a 20.1 μm layer (Experiment 1), or at a flow rate of 12.6 ml / min to form a 40.1 μm layer (Experiment 2). After the coating has spread evenly over the substrate, turn off the pump switch. A thin coating film is formed on the substrate by drying the applied coating in an oven at 50 °C for 2 minutes.

[0137] SEM images of the obtained materials are shown as Figures 4 - 7 (Experiment 1) and Figures 8 - 11 (Experiment 2). For comparison, a porous collagen matrix was coated with a 1.1% HA coating aqueous solution by the contact method at a thickness of 30 μm (Experiment 3) as described in Procedure 2b below:

[0138] Procedure 2b A knife hand coater was placed on the collagen. On the other hand, the knife was placed at a distance of 30 μm from the surface 21ompar collagen sheet (a rectangular shape from which 30 μm was removed by so - called CNC grinding). Next, the coating was placed behind the knife, and the knife was pulled on the surface 22ompar collagen sheet. The excess amount at the end in the length direction of the coating was then removed by wiping the surface (this part is not included in any measurement or consideration). The sample was dried in a conventional oven at 50 °C for 2 minutes.

[0139] SEM images of the obtained materials are shown as Figures 12 - 15.

[0140] The underwater sedimentation time and water absorption of the obtained materials were measured as described in Procedure 2c below (a summary of the results is in Table 1):

[0141] Procedure 2c: Weigh the wire mesh basket and record the weight (m1). Weigh the collagen sample, record the weight, and insert the sample into the wire mesh basket. Weigh the wire mesh basket containing the sample and record the weight (m2). Put RO water into a 1000 - ml beaker and adjust the water temperature. Place the beaker with water on the scale and tare it. Drop a wire mesh basket containing the sample horizontally into the beaker from a height of about 1 cm above the water surface. At the same time, start recording the time required for the wire mesh basket containing the sample to completely sink below the water surface. Take the wire mesh basket containing the sample out of the water, keep it above the water for about 30 seconds, and drain the sample. Weigh the wire mesh basket containing the sample and record the weight (m3).

[0142] The water absorption is calculated as A = (m3 - m2) / (m2 - m1).

[0143] For reference, the same measurements were performed using an uncoated collagen matrix (Experiment 4, SEM images are shown as Figures 2, 16, and 17), and ground and dried collagen (prepared by dispersing 2% finely ground collagen by vigorously mixing it in water, pouring this slurry onto tea paper, removing most of the water by suction through the tea paper, and drying the remaining slurry in a hot convection oven until a residual moisture content of 5 - 12% is achieved) (Experiment 5), and printing paper (Example 6).

[0144]

Table 1

[0145] The purpose of Experiment 5 was to simulate a compressed collagen foam film from the specification of U.S. Patent No. 3,800,792 (A). As can be seen from Table 1, both printing paper and the ground / compressed collagen film have very poor water permeability and water absorbency even when uncoated. If a coating is applied to this material, it can be clearly predicted that the numerical values will further decrease. In contrast, the comparative experiments of the coated porous collagen produced by the slot die method according to the present invention (Experiments 1 and 2) and the contact method (Experiment 3) have water absorbency comparable to that of uncoated porous collagen. However, the material produced by the non-contact slot die method according to the present invention has the further advantage of a shorter sedimentation time in water compared to the material produced by the contact method. For example, water takes about 40 seconds to pass through the material obtained in Experiment 2, while it takes about 60 seconds for the material obtained in Experiment 3, even though a thicker coating was applied in the former case. When the contact method is applied, it can be explained that the pores are partially blocked by the coating liquid that penetrates into the pores. When the coating flows through the porous substrate, it takes a longer time to dissolve the coating, resulting in an extended sedimentation time. Therefore, the porous collagen coated by the slot die non-contact method gets wet more quickly, which is particularly advantageous in skin treatment.

[0146] This effect can also be seen from the SEM images. In the top views of the coated collagen materials obtained by the non-contact slot die method (Figs. 4 and 8), pores and cavities can be clearly seen, but when the contact method is applied, almost no pores can be seen (Fig. 12). This difference is also observed when comparing the lower sides of the respective materials. In the bottom view of the material produced by the non-contact slot die method, there is no substantial difference when compared with uncoated porous collagen (Figs. 7, 11, and 2), but the lower side of the material obtained by the contact method clearly shows a decrease in porosity.

[0147] Example 3 A comparative experiment was conducted using a slot die coating solution with a viscosity of 3 Pa·s as described in the following procedure:

[0148] A porous collagen matrix was coated by applying a 0.4% HA coating aqueous solution at 40 μm and a viscosity of 3 Pa·s (measured with a viscometer) by the non-contact slot die method.

[0149] A porous collagen matrix substrate having dimensions of 460 mm × 330 mm × 1.5 mm and a density of 0.024 g / cm 3 is placed on a movable stage. The slot die is positioned at a distance of 600 μm from the surface of the substrate. The stage is configured to move horizontally at a speed of 1 m / min under the slot die. When the slot die reaches the position above the substrate, the pump is configured to feed the 0.4% HA coating aqueous solution at a flow rate of 12 ml / min to form a 40-μm layer. After the coating has spread evenly over the substrate, the pump switch is turned off. The applied coating is dried in an oven at 50°C for 3 minutes.

[0150] SEM images of the obtained materials are shown as Figures 18 - 22. As can be seen, with a coating solution having a viscosity of 3 Pa·s, efficient coating of the porous collagen could not be achieved. The top view of the coated sample (Figure 18) has a similar appearance to the top view of the uncoated material (Figure 2), indicating that the coating solution has passed through the pores and reached the lower side, as can also be seen from Figure 22. As a result, as shown in Figure 19, the thickness of the porous substrate has significantly collapsed. In the cross-sectional views (Figures 20 and 21), almost no cavities or gaps are observed, and only grooves are observed, indicating that the porous structure has been strongly affected. HA derived from the coating solution can be confirmed on both sides of the porous substrate. Therefore, the viscosity of the initial coating solution is a very important parameter for establishing a stable coating film on a porous material.

Claims

1. A method for producing a composition comprising a porous material, wherein the porous material is essentially flat and has a pore surface, and comprises a plurality of pores that are open and interconnected with each other, the method comprises: a) A step of providing a porous material, wherein the porous material is essentially flat and has a pore surface, and includes a plurality of pores that are open and interconnected, and the density of the porous material is in the range of 0.01 to 1 g / cm ３ Preferably in the range of 0.02 to 0.05 g / cm ３ Most preferably in the range of 0.02 to 0.04 g / cm ３ And the pores have an average diameter in the range of 10 to 150 μm; b) providing a coating liquid, wherein the viscosity of the coating liquid is in the range of 5 to 20 Pa·s, preferably in the range of 8 to 15 Pa·s, more preferably in the range of 10 to 14 Pa·s; c) providing a coating means for applying the coating liquid onto the surface of the porous material, wherein the coating means comprises a slot die; d) coating the porous material by applying a quantitative amount of the coating liquid onto the surface of the porous material by relatively moving the porous material and the coating means relative to each other at a speed in the range of 0.1 to 10 m / min to form a liquid layer; e) drying the liquid layer; comprising a method.

2. The method for producing a composition comprising a porous material according to claim 1, wherein the density of the porous material increases by 10 to 30%, preferably 10 to 20% after coating.

3. The quantitative amount of coating liquid applied onto the surface of the porous material in step d) is in the range of 0.5 to 200 g / m ２ , preferably in the range of 10 to 100 g / m ２ , most preferably in the range of 10 to 30 g / m ２ . A method for producing a composition comprising the porous material according to claim 1 or claim 2.

4. The method for producing a composition comprising a porous material according to any one of claims 1 to 3, wherein the coating liquid comprises a solvent component and a film-forming component.

5. The method for producing a composition comprising a porous material according to claim 4, wherein the solvent component is water.

6. The method for producing a composition comprising a porous material according to claim 5, wherein the water content in the coating liquid is in the range of 0.5 to 50 wt%, preferably in the range of 2 to 35 wt%, more preferably in the range of 3 to 30 wt%.

7. The method for producing a composition comprising a porous material according to any one of claims 4 to 6, wherein the film-forming component is selected from the group consisting of hyaluronic acid (HA); polyacrylate; polyurethane; and polysaccharides such as alginate, nanocellulose, or carboxymethyl cellulose (CMC); or a mixture thereof.

8. The method for producing a composition comprising a porous material according to any one of claims 1 to 7, wherein the biomaterial is collagen.

9. A composition comprising a porous material obtainable by the method according to any one of claims 1 to 8.

10. The following: A porous substrate including a first major surface and a second major surface, wherein the porous substrate is essentially flat and includes a plurality of open and interconnected pores, pore surfaces extending through the porous substrate from the first major surface to the second major surface, and the pores having an average diameter in the range of 10 to 150 μm; A coating on the first major surface and / or the second major surface of the porous substrate, the coating including hyaluronic acid (HA); polyacrylate; polyurethane; or a polysaccharide such as alginate, nanocellulose, or carboxymethyl cellulose (CMC); or a mixture thereof; A composition comprising: The composition is characterized in that it has a water absorption capacity in the range of 10 to 50 g, preferably in the range of 20 to 40 g, per 1 g of the composition. Composition.

11. The composition according to claim 10, wherein the coating in the coated porous material is bonded to the first major surface and / or the second major surface of the porous substrate via non-covalent bonds.

12. The composition according to claim 10 or claim 11, wherein the coating on the first major surface and / or the second major surface of the substrate further contains water.

13. The composition according to any one of claims 10 to 12, wherein the amount of the coating in the composition is in the range of 0.1 to 10 wt%, preferably in the range of 0.5 to 3 wt%, based on the weight of the composition.

14. The composition according to any one of claims 10 to 13, for use as a medicament.

15. The composition according to any one of claims 10 to 13, for use in the treatment of stagnant wounds, split skin grafts, and ulcers.

Images