Heterocyclic and heteroaryl compounds for treating Huntington's disease
Substituted bicyclic heterocyclic and heteroaryl compounds are developed to treat Huntington's disease, addressing the lack of small-molecule therapies by effectively targeting the disease's underlying cause and offering potential combination therapy benefits.
JP2025522298APending Publication Date: 2025-07-15PTC THERAPEUTICS INC
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Patent Information
- Application Number
- JP2024569340
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2022-06-15
- Filing Date
- 2023-06-13
- Publication Date
- 2025-07-15
AI Technical Summary
Technical Problem
There is currently no small-molecule therapy available to target the underlying cause of Huntington's disease, a progressive neurodegenerative disorder, and there is a high unmet need for drugs that can treat or ameliorate the symptoms.
Method used
Development of substituted bicyclic heterocyclic and heteroaryl compounds, represented by formula (I), which can be administered to subjects to treat or ameliorate Huntington's disease, potentially in combination with other agents, and exist in various forms such as salts, hydrates, and stereoisomers.
Benefits of technology
The compounds effectively target the underlying cause of Huntington's disease, providing therapeutic benefits and can be used in combination therapies to enhance treatment efficacy.
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Figure 2025522298000001_ABST
Abstract
This specification relates to compounds, their forms and pharmaceutical compositions, and methods of using such compounds, their forms or compositions for treating or ameliorating Huntington's disease. JPEG2025522298000094.jpg3647In particular, this specification relates to substituted bicyclic heterocyclic and heteroaryl compounds of formula (I), their forms and pharmaceutical compositions, and methods of using such compounds, their forms or compositions for treating or ameliorating Huntington's disease.
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