Polymer tandem dyes having a spacing linker group
Water-soluble dyes with a specific linker structure enhance FRET efficiency and brightness, addressing orientation and pH sensitivity issues, enabling effective visual detection of biomolecules in aqueous environments.
Patent Information
- Application Number
- JP2024573519
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2022-06-15
- Filing Date
- 2023-05-30
- Publication Date
- 2025-07-23
AI Technical Summary
Existing fluorescent and chromogenic dyes face challenges in achieving high molar brightness and efficient Förster resonance energy transfer (FRET) due to orientation and positioning constraints, as well as pH sensitivity, limiting their effectiveness in aqueous environments for biomolecule analysis.
Development of water-soluble fluorescent and chromogenic dyes with a specific linker structure that covalently links FRET acceptor and donor moieties, optimizing intramolecular interactions to enhance FRET absorption and emission, and enabling bright fluorescence or coloration without prior irradiation.
The dyes exhibit strong chromogenic or fluorescent properties, enabling efficient FRET processes and easy visual detection of biomolecules, with improved brightness and stability in aqueous solutions.
Smart Images
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