Self-expandable patch assembly for delivery of therapeutic agents to the intestinal wall - Patent Application 20070122997

The self-inflatable patch assembly with gas-generating reaction chambers addresses the challenges of deploying piercing needles and gas generation in oral drug delivery, ensuring effective and controlled expansion for therapeutic agent delivery across the intestinal lumen.

JP2025527721APending Publication Date: 2025-08-22ALMA THERAPEUTICS LTD
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Patent Information

Application Number
JP2025511795
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2022-08-22
Filing Date
2023-08-22
Publication Date
2025-08-22

AI Technical Summary

Technical Problem

Existing drug delivery technologies for orally administered therapeutic agents face challenges in effectively deploying piercing needles and generating gas for inflation due to conflicting material requirements and intestinal environment conditions, leading to inefficiencies and potential gas leakage.

Method used

A self-inflatable patch assembly with a flexible, inflatable patch and auxiliary gas-generating reaction chambers, configured to generate gas through water-sensitive formulations, maintains gas confinement while allowing water absorption, ensuring controlled expansion and delivery of therapeutic agents across the intestinal lumen.

Benefits of technology

The patch assembly achieves sustained gas generation for extended periods, providing sufficient pressure for needle deployment and therapeutic agent delivery, while maintaining structural integrity and minimizing gas leakage.

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Abstract

An embodiment of the present invention comprises: 1. A self-expanding patch assembly for intraluminal drug delivery, comprising: a flexible, inflatable patch having a water and gas impermeable wall defining an interior chamber and an array of piercing needles disposed on a surface thereof; one or more auxiliary gas-generating reaction chambers distinct from and in fluid communication with the inflatable patch, the reaction chambers being defined by flexible reaction chamber walls containing a water-sensitive gas-generating formulation, at least a portion of the reaction chamber walls having a water-permeable outer surface; and the patch assembly is configured such that each gas generating formulation or set thereof is retained within each auxiliary gas generating reaction chamber during expansion; A patch assembly is provided.
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