Substituted 3-fluorobenzenepropanoate compounds, their preparation methods, pharmaceutical compositions and uses

3-fluorobenzenepropanoate-based compounds address the limitations of current NSAIDs by enhancing stability and reducing side effects, offering improved anti-inflammatory activity and broader administration options.

JP2025535095APending Publication Date: 2025-10-22TIANJIN GUDUI BIOLOGICAL MEDICAL TECH INC
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Patent Information

Application Number
JP2025520708
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2023-09-26
Filing Date
2023-10-07
Publication Date
2025-10-22

AI Technical Summary

Technical Problem

Current NSAIDs, such as flurbiprofen, suffer from gastrointestinal side effects and instability in the gastrointestinal environment, limiting their oral administration and efficacy.

Method used

Development of 3-fluorobenzenepropanoate-based compounds with anti-inflammatory activity, including optical isomers and pharmaceutically acceptable salts, which can be prepared through various synthesis methods to enhance stability and reduce side effects.

Benefits of technology

The compounds demonstrate effective anti-inflammatory activity and improved stability, potentially reducing gastrointestinal irritation and enabling broader application beyond intravenous administration.

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Abstract

A substituted 3-fluorobenzenepropanoate compound represented by formula (I), or an optical isomer thereof, or a pharmaceutically acceptable salt thereof, or a solvate (e.g., hydrate) thereof, or a clathrate thereof, or a meso / racemic isomer thereof, or a eutectic compound thereof, or an isotope-labeled compound thereof, or a nitrogen oxide thereof, and pharmaceutical compositions and uses thereof. The compound has significantly improved pharmaceutical activity and can effectively treat and / or prevent inflammation, pain, fever, cancer, or Alzheimer's disease. [Formula 1] TIFF2025535095000126.tif33170
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Citation Information

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