Drug dispensing devices, kits and related methods

Abstract

The present disclosure provides on-demand drug dispensing patches, kits, and related methods. The flexible patch is configured to contain a drug and dispense the drug on demand upon compression of the patch through its thickness. The patch may include an adhesive layer for removably bonding the patch to a surface, at least one reservoir layer positioned over the adhesive layer and configured to absorb and retain the drug therein, at least one dispenser layer positioned over the at least one reservoir layer, the dispenser layer having a plurality of solid portions and an array of a plurality of openings, and configured to inhibit evaporation of the drug and control drug flow therefrom upon compression of the patch through its thickness, and at least one backer layer positioned between the adhesive layer and the at least one reservoir layer and being substantially impermeable to the drug. At least one reservoir layer may be free of absorbed drug therein and may be provided with a reservoir for the drug.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application claims the benefit of priority to U.S. Provisional Patent Application No. 63 / 418,041, filed October 21, 2022, entitled "Drug Dispensing Devices, Kits, and Related Methods," which is expressly incorporated herein by reference in its entirety. Field of the Disclosure

[0002] The present disclosure relates generally to on-demand drug (e.g., antiseptic) dispensing devices, kits, and related methods. More specifically, the present disclosure relates to drug (e.g., antiseptic) dispensing adhesive patches configured for removably affixing to a user or surface to provide on-demand dispensing of drug over an extended period of time.

[0003] There is substantial evidence that pathogens (i.e., disease-causing microorganisms such as various viruses, bacteria, fungi, and parasites) can be transmitted from a first person to a second person by the first person physically touching the second person (e.g., via a handshake, hug, kiss, etc.) or by the first person physically touching or otherwise becoming infected (e.g., via one or more respiratory functions, pets, etc.) with a common object (e.g., a surface, object, knob, button, handle, handrail, key, screen, currency, card, etc.) that is subsequently physically touched by the second person. Most commonly, pathogens are passed between people by physical contact via hands—the pathogen becomes present on the first person's hands and is transferred to the second person's hands through physical contact with the first person's hands, or with an object that the first person's hands have previously touched, or an object that the first person has infected via one or more respiratory functions (e.g., breathing, coughing, sneezing, talking, etc.) or by a third party (e.g., via another person, pet, etc.). Thus, not only can a person become infected with a pathogen by touching their eyes, nose or mouth with their hands (or with an object that has been touched by their hands), but they can also pass the pathogen to one or more other people by touching a public object.

[0004] Because many infectious pathogens (e.g., viruses, e.g., the common cold) are transmitted and spread to others primarily through physical contact with the hands, conventional medical wisdom teaches that the best way to prevent the transmission and spread of most pathogens (and resulting infections) is to thoroughly and frequently disinfect / sanitize / sterilize your hands throughout the day by washing them with soap and water. In addition to and / or instead of washing your hands, you can utilize topical disinfectants / sanitizers / sterilants, such as denatured alcohol, antibacterial hand gel, or antibacterial hand lotion, to further protect your hands.

[0005] While these measures help control the spread of many pathogens present on the skin, they are only effective if performed routinely and systematically. Unfortunately, many individuals lack ready access to facilities for thoroughly washing their hands with soap and water and / or topical disinfectants. For example, many liquid and / or gel topical disinfectants are packaged in bottles configured with spray or squeeze dispensers. These bottled disinfectants require the bottle to be carried by the individual, removed when the disinfectant is needed, and manually opened and applied (most typically to the hands). As another example, germicidal wipes or towelettes containing liquid topical disinfectants are sometimes available, but they suffer from the same drawbacks as bottled disinfectants. Thus, liquid and / or gelatinous disinfectants are not readily available for extended periods of time. Therefore, they are often used less frequently than they would be if they were readily available on demand.

[0006] Hand sanitizer stations containing relatively large reservoirs of topical disinfectant are also common. Such stations are typically found only in high-concentration spaces, areas where pathogens are more prevalent, and / or areas where vulnerable populations are located. Due to their scarcity, sanitizer stations are unable to protect users from the constant onslaught of surfaces and third-party individuals that people routinely touch.

[0007] Additionally, it should be noted that other liquid and / or gelatinous agents and materials that people want to receive in regular doses (or dispense periodically) suffer from the same drawbacks as those discussed above with respect to disinfectants / sanitizers.

[0008] It is thereby an object of the on-demand drug dispensing devices and kits, and associated methods, provided herein to address one or more of the aforementioned problems of the prior art. The on-demand drug dispensing devices, kits, and associated methods disclosed herein address the aforementioned shortcomings of current drug dispensing devices and associated methods by, among other things, providing a removably attachable device / patch that provides a user with on-demand access (via dispensed dose or volume thereof) of a liquid and / or gelatinous drug (e.g., antiseptic) over an extended period of time. Overview

[0009] Disclosed herein are on-demand medication (e.g., disinfectant) dispensing devices (and disinfection methods utilizing such devices) that can be removably attached to a user or surface, providing quick and easy access to the medication over an extended period of time. The present disclosure provides such devices and kits, as well as related methods, for dispensing medication onto a user's body (e.g., the skin of a user's hands) via an adhesive patch. In embodiments in which the medication is a disinfectant / antiseptic solution or gel, the devices, kits, and methods provide for manual dispensing of the disinfectant / antiseptic onto a user (e.g., the user's hands) and potential transfer of the disinfectant / antiseptic to another part of the user, another person, or an inanimate object. Such on-demand disinfectant dispensing devices, kits, and methods can thereby provide on-demand disinfectant / antiseptic to one or more people and / or surfaces.

[0010] On-demand medication dispensing devices and kits provide a simple, cost-effective solution for selectively providing access to and dispensing of liquid or gelatinous medications, such as, but not limited to, alcohol-based sanitizer / antiseptic solutions or gels.

[0011] The devices are self-contained, with no containers to carry and open, contain the medication within the device (i.e., a spill-free solution), and do not require pouring or spraying to dispense the medication. In some embodiments, on-demand medication dispensing devices and kits may be configured with an adhesive patch configured to be removably attached to a user, such as to the user's skin or the user's clothing (or any other inanimate object carried or worn by the user). In some embodiments, the on-demand medication dispensing patch may be wearable and configured to be removably attached to an active point / contact area of ​​the user that would benefit from having the medication at that location, such as a sanitizer / antiseptic on the inside of the user's hand (e.g., on the palm and / or fingers). In some embodiments, the on-demand medication dispensing wearable device may be configured to be removably attached to a passive area of ​​the user's skin (or an object worn / carried by the user) (or on an inanimate object remote from the user) spaced from the user's contact point / contact area to enable selective application of the medication from the device to the user's contact area. For example, a passive on-demand disinfectant dispensing wearable patch device may be configured to be removably attached to the back of a user's hand (or the user's forearm) or on / in clothing worn by the user, and the user may wipe their fingers / hands on / across the device to apply disinfectant (thereby disinfecting the fingers / hands). In such passive disinfection embodiments, the on-demand disinfectant dispensing wearable device provides rapid, discrete, on-demand access to a germicide / disinfectant that disinfects a person's touchpoints / contact areas (e.g., hands or other skin surfaces) with a swipe / touch of the device.

[0012] Embodiments of the on-demand drug dispensing device may be configured to be applied to an active or passive surface area of ​​a user (or object), disinfecting it, and potentially passing it on (i.e., paying it forward) to a third party who subsequently comes into contact with the surface area. In this way, the on-demand disinfectant dispensing device can provide a level of disinfection safety for the user, with the added benefit of protecting others who may come into contact with the common surface / object. Thus, community touchpoints can be sanitized, providing an essential part of the health and wellness of the community as a whole.

[0013] The on-demand drug dispensing device of the present disclosure is configured as an on-demand sustained liquid / gelatinous drug delivery dispensing patch. The on-demand drug delivery dispensing patch includes an adhesive layer or portion configured to removably adhere to a user or an inanimate object. The on-demand drug delivery dispensing patch also includes at least one reservoir layer configured to absorb and retain a liquid / gelatinous drug therein, and at least one metering / controlled-release or dispensing layer positioned over at least a portion of the at least one reservoir layer. The at least one metering / controlled-release layer is configured to control the release of drug (e.g., the amount dispensed and the pressure required to dispense) from the at least one reservoir layer at / to the outer surface of the patch (and thus to the user) and to mitigate / inhibit evaporation of the liquid / gelatinous drug within the at least one reservoir layer. In some embodiments, the on-demand drug delivery dispensing patch may include at least one backer layer disposed between the adhesive layer and at least one reservoir layer that is impermeable to the liquid / gelatinous drug, such that the liquid / gelatinous drug is prevented from interacting with the adhesive of the adhesive layer and is thereby retained on the at least one backer layer. In some embodiments, the at least one reservoir layer, the at least one metered / control dispensing layer, and the at least one backer layer are heat welded or sealed together around the periphery of the patch, forming a peripheral barrier or boundary around an interior region or portion of the patch that substantially retains the drug within the at least one reservoir layer within the interior region of the patch until selectively dispensed by a user via pressure applied to the outer surface of the patch such that the at least one reservoir layer is compressed (through its thickness).

[0014] In one aspect, the present disclosure provides an on-demand liquid or gelatinous drug dispensing kit comprising: a container containing a quantity of a liquid or gelatinous drug; and a flexible patch configured to contain the drug and to dispense the drug on demand by compressing the patch through its thickness. The patch comprises: an adhesive layer configured to removably couple the patch to a surface and defining an inner surface of the patch; at least one reservoir layer configured to absorb and retain the drug therein and positioned over the adhesive layer through its thickness; at least one dispenser layer positioned over the at least one reservoir layer through its thickness and including a plurality of solid portions and an array of a plurality of apertures extending therethrough, the dispenser layer configured to inhibit evaporation of the drug when contained within the at least one reservoir layer and to control the flow of the drug from the at least one reservoir layer upon compression through the thickness of the patch; and at least one backer layer disposed between the adhesive layer and the at least one reservoir layer through its thickness and being substantially impermeable to the drug. The solid portion of the at least one dispenser layer and the portion of the at least one reservoir layer underlying the plurality of openings in the at least one dispenser layer define an outer surface of the patch. The at least one reservoir layer is free of drug absorbed therein.

[0015] In some embodiments, the adhesive is a biocompatible adhesive. In some embodiments, the patch further comprises an inner protective film layer extending over and removably coupled to the adhesive layer. In some embodiments, the patch further comprises an outer protective film layer extending over and removably coupled to the outer surface of the patch. In some embodiments, the patch further comprises a mechanical connector that can be configured to removably attach the patch to a subject.

[0016] In some embodiments, the agent is a disinfectant. In some such embodiments, the disinfectant is a biocompatible disinfectant. In some embodiments, the disinfectant comprises ethyl, isopropyl, ethanol (ethyl alcohol), triclosan, triclocarban, benzalkonium chloride, benzethonium chloride, or a combination thereof. In some embodiments, the disinfectant comprises ethanol (ethyl alcohol). In some embodiments, the disinfectant comprises a dynamic viscosity at 20 degrees Celsius in the range of about 4 (Pa·s) (m² / s) to about 15 (Pa·s) (m² / s).

[0017] In some embodiments, the agent comprises a medicine or vitamin. In some embodiments, the agent comprises a pesticide. In some embodiments, the agent comprises a fragrance. In some embodiments, the agent comprises a food product. In some embodiments, the agent comprises a cleaning agent. In some embodiments, the agent comprises a paint. In some embodiments, the agent comprises an oil.

[0018] In some embodiments, the at least one backer layer is substantially impermeable to the drug and air. In some embodiments, the at least one backer layer comprises a solid sheet of material. In some embodiments, the at least one backer layer comprises a polymer layer. In some embodiments, the at least one backer layer comprises at least one polyethylene layer, polypropylene layer, styrene layer, polyetheretherketone layer, acrylic layer, polyvinyl chloride layer, polyurethane layer, Teflon (polytetrafluoroethylene) layer, syrlyn layer, or a combination thereof.

[0019] In some embodiments, at least one dispenser layer comprises a sheet of material that is impermeable to the drug. In some embodiments, at least one dispenser layer comprises a sheet of material that is impermeable to air. In some embodiments, at least one dispenser layer comprises a polymer layer. In some embodiments, at least one dispenser layer comprises at least one polyethylene layer, polypropylene layer, styrene layer, polyetheretherketone layer, acrylic layer, polyvinyl chloride layer, polyurethane layer, Teflon (polytetrafluoroethylene) layer, syrlyn layer, or combinations thereof. In some embodiments, the solid portion of at least one dispenser layer comprises between about 10% and about 65% of the total area of ​​the outer surface. In some embodiments, the plurality of openings of at least one dispenser layer is within about 50 mm of the outer surface. 2 ~about 300mm 2 In some embodiments, each of the plurality of openings in the at least one dispenser layer has an average total area within the range of about 0.05 mm on the outer surface. 2 ~about 0.3mm 2 Includes the total area within the range.

[0020] In some embodiments, at least one reservoir layer comprises one or more layers of fabric, Gore-Tex, gauze, absorbent gel, polymer, paper, foam, or combinations thereof. In some embodiments, at least one reservoir layer comprises one or more layers of polymer fibers, cotton fibers, silicone fibers, hydrogel, or combinations thereof. In some embodiments, at least one reservoir layer comprises a fabric layer of nonwoven polymer fibers. In some embodiments, at least one reservoir layer comprises a layer of nonwoven polyethylene and / or polypropylene fibers. In some embodiments, at least one reservoir layer comprises a natural or synthetic nonwoven fabric layer. In some embodiments, at least one reservoir layer is configured to absorb and retain between about 2 grams and about 50 grams of drug. In some embodiments, at least one reservoir layer has a density of about 1,000 g / mm 2~Approx. 2,500g / mm 2 In some embodiments, the at least one reservoir layer comprises a drug absorption rate of at least 5 g / sec for at least the first 5 seconds of water contact. In some embodiments, when the drug is contained within the at least one reservoir layer, the patch has a detached agent capacity of at least 1 gram / mm applied to its outer surface acting through the thickness. 2 The compressive force of the adhesive is configured to cause the agent to flow through the plurality of openings onto the exterior surface and / or onto an object on the exterior surface.

[0021] In some embodiments, when the drug is contained within at least one reservoir layer, the patch is configured to evaporate no more than 5 grams of drug over 1.5 hours in an ambient environment of non-moving air at 20°C.

[0022] In some embodiments, the patch has a total thickness in the range of about 0.05 mm to about 3 mm. In some embodiments, an inner portion of the patch defines a first maximum thickness, and a peripheral edge portion of the patch extending around the inner portion to define an outer extent of the patch defines a second thickness that is less than the first thickness. In some embodiments, the peripheral edge portion of the patch defining the outer extent of the patch includes at least one reservoir layer, and the at least one dispenser layer and the at least one backer layer are bonded to one another. In some embodiments, the at least one reservoir layer, the at least one dispenser layer, and the at least one backer layer are heat-, radio-frequency-, or ultrasonically-welded to one another at the peripheral edge portion of the patch.

[0023] In some embodiments, the adhesive comprises a biocompatible adhesive. In some embodiments, the front outer adhesive layer comprises an acrylic pressure sensitive adhesive. In some embodiments, the adhesive layer comprises an adhesive and scrim layer structure.

[0024] In some embodiments, the reservoir is separate and distinct from the flexible patch. In some embodiments, the reservoir is incorporated into or coupled to the flexible patch. In some embodiments, the amount of medication is contained within a manually destructible shell or envelope. In some embodiments, the shell or envelope is contained within the flexible patch or disposed adjacent to at least one dispenser layer of the flexible patch.

[0025] In another aspect, the present disclosure provides an on-demand drug dispensing pocket device, the device comprising: a flexible drug-impermeable pocket having a front surface, a rear surface, a bottom portion, a top portion, side portions, and an internal cavity between the interior sides of the front and rear surfaces, the internal cavity being closed at the bottom portion and the side portions and open or openable at the top portion, the flexible drug-impermeable pocket being impermeable to a liquid or gelatinous drug; and at least one reservoir-dispenser layer disposed within the internal cavity of the pocket, the at least one reservoir-dispenser layer configured to absorb and retain a liquid or gelatinous drug therein and to control the flow of the drug from the at least one reservoir layer upon compression of the at least one reservoir layer when the drug is retained therein.

[0026] In some embodiments, the device further comprises an attachment mechanism on an exterior of the rear surface configured to couple the device to an object. In some embodiments, the attachment mechanism is configured to releasably couple the device to the object. In some embodiments, the attachment mechanism comprises a clip or flap member extending from the rear surface.

[0027] In some embodiments, the attachment mechanism comprises an adhesive layer positioned over at least a portion of an outer side of the rear surface configured to removably couple the device to a surface. In some embodiments, the adhesive layer comprises a biocompatible adhesive. In some embodiments, the adhesive layer comprises an acrylic pressure-sensitive adhesive. In some embodiments, the adhesive layer comprises an adhesive and scrim layer structure bonded to the outer side of the rear surface via the adhesive. In some embodiments, the device further comprises a removable back liner layer extending over the adhesive layer to temporarily cover the adhesive layer.

[0028] In some embodiments, the device further comprises an attachment mechanism on the exterior of the front surface configured to couple the device to an object. In some embodiments, the attachment mechanism on the exterior of the front surface is configured to removably couple the device to the object. In some embodiments, the attachment mechanism on the exterior of the front surface comprises a clip or flap member extending from the rear surface.

[0029] In some embodiments, the attachment mechanism on the exterior of the front surface comprises an adhesive layer located over at least a portion of the exterior configured to removably couple the device to a surface. In some embodiments, the adhesive layer on the exterior of the front surface comprises a biocompatible adhesive. In some embodiments, the adhesive layer on the exterior of the front surface comprises an acrylic pressure-sensitive adhesive. In some embodiments, the adhesive layer on the exterior of the front surface comprises an adhesive and scrim layer structure bonded to the exterior of the front surface via the adhesive. In some embodiments, the device further comprises a removable front liner layer extending over the adhesive layer to temporarily cover the adhesive layer on the exterior of the front surface.

[0030] In some embodiments, at least one reservoir layer contains an amount of drug absorbed and retained therein. In some embodiments, at least one reservoir layer is drug-free, and the device further comprises a drug reservoir for selectively applying drug to the interior of the at least one reservoir layer. In some embodiments, when drug is contained within the at least one reservoir layer, the device is configured such that 5 grams or less of the drug evaporates over 1.5 hours in an ambient environment of non-moving air at 20°C.

[0031] In some embodiments, the agent comprises a germicidal antiseptic. In some embodiments, the antiseptic is a biocompatible antiseptic. In some embodiments, the antiseptic comprises ethyl, isopropyl, ethanol (ethyl alcohol), triclosan, triclocarban, benzalkonium chloride, benzethonium chloride, or a combination thereof. In some embodiments, the antiseptic comprises ethanol (ethyl alcohol).

[0032] In some embodiments, the agent comprises a medicine or vitamin. In some embodiments, the agent comprises a pesticide. In some embodiments, the agent comprises a fragrance. In some embodiments, the agent comprises a food product. In some embodiments, the agent comprises a cleaning agent. In some embodiments, the agent comprises a paint. In some embodiments, the agent comprises an oil. In some embodiments, the agent comprises a kinematic viscosity at 20 degrees Celsius in the range of about 4 (Pa·s) (m2 / s) to about 15 (Pa·s) (m2 / s).

[0033] In some embodiments, the at least one reservoir dispenser layer comprises at least one dispenser layer having a plurality of solid portions and an array of a plurality of openings extending through its thickness, the at least one dispenser layer configured to inhibit evaporation of the drug and to control flow of the drug from the at least one reservoir dispenser layer upon compression in the thickness direction of the at least one reservoir dispenser layer when the drug is contained within the at least one reservoir dispenser layer.

[0034] In some embodiments, at least one dispenser layer defines an innermost surface of the at least one reservoir-dispenser layer and is exposed to the interior cavity. In some embodiments, at least one dispenser layer comprises a sheet of material that is impermeable to drugs. In some embodiments, at least one dispenser layer comprises a sheet of material that is impermeable to air. In some embodiments, at least one dispenser layer comprises a polymer layer. In some embodiments, at least one dispenser layer comprises at least one polyethylene layer, polypropylene layer, styrene layer, polyetheretherketone layer, acrylic layer, polyvinyl chloride layer, polyurethane layer, Teflon (polytetrafluoroethylene) layer, syrlyn layer, or combinations thereof. In some embodiments, the solid portion of the at least one dispenser layer comprises between about 10% and about 65% of the total area of ​​the outer surface. In some embodiments, the plurality of openings of the at least one dispenser layer is within about 50 mm of the outer surface. 2 ~about 300mm 2 In some embodiments, each of the plurality of openings in the at least one dispenser layer has an average total area within the range of about 0.05 mm on the outer surface. 2 ~about 0.3mm 2 Includes the total area within the range.

[0035] In some embodiments, the at least one reservoir-dispenser layer comprises at least one reservoir layer configured to absorb and retain a medication therein, hi some embodiments, the at least one reservoir layer is located below the at least one dispenser layer.

[0036] In some embodiments, at least one reservoir layer comprises one or more layers of fabric, Gore-Tex, gauze, absorbent gel, polymer, paper, foam, or combinations thereof. In some embodiments, at least one reservoir layer comprises one or more layers of polymer fibers, cotton fibers, silicone fibers, hydrogel, or combinations thereof. In some embodiments, at least one reservoir layer comprises a fabric layer of nonwoven polymer fibers. In some embodiments, at least one reservoir layer comprises a layer of nonwoven polyethylene and / or polypropylene fibers. In some embodiments, at least one reservoir layer comprises a natural or synthetic nonwoven fabric layer.

[0037] In some embodiments, at least one reservoir layer is configured to absorb and retain between about 2 grams and about 50 grams of drug. In some embodiments, at least one reservoir layer is configured to absorb and retain between about 1,000 g / mm 2 ~Approx. 2,500g / mm 2 In some embodiments, the at least one reservoir layer comprises a drug absorption rate of at least 5 g / sec for at least the first 5 seconds of water contact. In some embodiments, the at least one reservoir dispenser layer comprises a drug absorption rate of at least 1 gram / mm applied to its exposed inner surface acting through the thickness. 2 The compressive force of the medicament is configured to cause the medicament to flow therefrom onto the exposed inner surface.

[0038] In some embodiments, the at least one reservoir-dispenser layer comprises at least one backer layer underlying the at least one reservoir layer, the at least one backer layer being substantially impermeable to the drug. In some embodiments, the at least one backer layer is substantially impermeable to the drug and air. In some embodiments, the at least one backer layer comprises a solid sheet of material. In some embodiments, the at least one backer layer comprises a polymer layer. In some embodiments, the at least one backer layer comprises at least one polyethylene layer, polypropylene layer, styrene layer, polyetheretherketone layer, acrylic layer, polyvinyl chloride layer, polyurethane layer, Teflon (polytetrafluoroethylene) layer, syrlyn layer, or a combination thereof.

[0039] In some embodiments, the front and / or rear surface of the pocket is substantially impermeable to the agent. In some embodiments, the front and / or rear surface of the pocket is substantially impermeable to the agent and air. In some embodiments, the front and / or rear surface of the pocket comprises a solid sheet of material. In some embodiments, the front and / or rear surface of the pocket comprises a polymer layer. In some embodiments, the front and / or rear surface of the pocket comprises at least one polyethylene layer, polypropylene layer, styrene layer, polyetheretherketone layer, acrylic layer, polyvinyl chloride layer, polyurethane layer, Teflon (polytetrafluoroethylene) layer, syrlyn layer, or a combination thereof.

[0040] In some embodiments, the at least one reservoir-dispenser layer comprises a total thickness in the range of about 0.05 mm to about 3 mm. In some embodiments, an inner portion of the at least one reservoir-dispenser layer defines a first maximum thickness, and a peripheral edge portion of the at least one reservoir-dispenser layer extending around the inner portion and defining an outer extent of the at least one reservoir-dispenser layer defines a second thickness that is less than the first thickness.

[0041] In some embodiments, the at least one reservoir-dispenser layer comprises at least one dispenser layer and at least one reservoir layer bonded together. In some embodiments, the at least one dispenser layer is positioned over the at least one reservoir layer, and the at least one reservoir layer is bonded to the inner or outer surface. In some embodiments, the at least one reservoir layer, the at least one dispenser layer, and the inner or outer surface are heat-, radio-frequency-, or ultrasonically welded together around the periphery of the patch. In some embodiments, the at least one reservoir-dispenser layer comprises multiple sublayers bonded together.

[0042] In some embodiments, the device further comprises a drug. In some embodiments, a quantity of the drug is absorbed into at least one reservoir-dispenser layer. In some embodiments, a quantity of the drug is contained within a manually breakable shell or envelope. In some embodiments, the shell or envelope is contained within or disposed on at least one reservoir-dispenser layer. In some embodiments, the device is configured as an on-demand drug-dispensing pocket patch.

[0043] It should be understood that all combinations of the foregoing concepts and additional concepts described in more detail below (unless such concepts are mutually inconsistent) are considered to be part of the inventive subject matter disclosed herein and may be used to achieve the benefits and advantages described herein.

[0044] These and other objects, features and advantages of the present disclosure will become apparent from the following detailed description of various aspects of the disclosure, taken in conjunction with the accompanying drawings. [Brief explanation of the drawings]

[0045] These and other features, aspects, and advantages of the present disclosure may be better understood upon reading the following detailed description in conjunction with the accompanying drawings. It should be understood that at least some of the drawings are not necessarily to scale (although at least some of the drawings may be drawn to scale). In certain figures, details that are not necessary for an understanding of the disclosure or that make other details difficult to perceive may be omitted. It should, of course, be understood that the present disclosure is not necessarily limited to the particular embodiments shown in the figures. Like reference numerals are utilized throughout the figures to represent like aspects shown in the figures.

[0046] [Figure 1] 1 illustrates a top perspective, partially exploded view of an on-demand drug dispensing patch according to one embodiment of the present disclosure.

[0047] [Figure 2] 1 illustrates a top perspective exploded view of an on-demand drug dispensing patch according to one embodiment of the present disclosure.

[0048] [Figure 3] 1 illustrates another top perspective exploded view of an on-demand drug dispensing patch according to an embodiment of the present disclosure.

[0049] [Figure 4] 1 illustrates a top perspective view of an on-demand drug dispensing patch according to one embodiment of the present disclosure.

[0050] [Figure 5] 5 illustrates a top view of the on-demand drug dispensing patch of FIG. 4 according to one embodiment of the present disclosure.

[0051] [Figure 6] 5 illustrates a side view of the on-demand drug dispensing patch of FIG. 4 according to one embodiment of the present disclosure.

[0052] [Figure 7] 5 illustrates a plurality of on-demand drug dispensing patches of FIG. 4 mounted on a support member according to one embodiment of the present disclosure.

[0053] [Figure 8] 1 shows a top perspective view of a kit including a plurality of on-demand drug dispensing patches and a container of a quantity of drug according to one embodiment of the present disclosure.

[0054] [Figure 9] 9 illustrates a top perspective view of application of a drug from a container of the kit of FIG. 8 onto an on-demand drug dispensing patch of the kit of FIG. 8 coupled to a user according to one embodiment of the present disclosure.

[0055] [Figure 10] FIG. 1 illustrates a top perspective view of a user compressing an on-demand drug dispensing patch to dispense a quantity of drug from the patch according to one embodiment of the present disclosure.

[0056] [Figure 11] FIG. 10 illustrates another top perspective view of a user compressing an on-demand drug dispensing patch to dispense a quantity of drug from the on-demand drug dispensing patch according to an embodiment of the present disclosure.

[0057] [Figure 12] 1 shows a top perspective view of an on-demand drug dispensing pocket patch according to one embodiment of the present disclosure. FIG.

[0058] [Figure 13] 13 illustrates another top perspective view of the on-demand drug dispensing pocket patch of FIG. 12 with the adhesive liner layer partially removed according to an embodiment of the present disclosure.

[0059] [Figure 14] FIG. 14 illustrates a top perspective cross-sectional view of the on-demand drug dispensing pocket patch of FIG. 13 according to one embodiment of the present disclosure.

[0060] [Figure 15A] FIG. 13 illustrates a top perspective view of a user inserting a finger into the on-demand drug dispensing pocket patch of FIG. 12 according to one embodiment of the present disclosure.

[0061] [Figure 15B] 15B illustrates a bottom perspective view of a user using the on-demand medication dispensing pocket patch of FIG. 15A to dispense a dose of medication onto a finger according to one embodiment of the present disclosure.

[0062] [Figure 15C] 15B illustrates a top perspective view of a user using the on-demand medication dispensing pocket patch of FIG. 15A to dispense a dose of medication onto a finger according to one embodiment of the present disclosure.

[0063] [Figure 16] FIG. 1 illustrates a top perspective view of a resealable on-demand drug dispensing pocket patch according to one embodiment of the present disclosure. Detailed Description of the Drawings

[0064] Aspects of the present disclosure and specific examples, features, advantages, and details thereof are described more fully below with reference to non-limiting examples illustrated in the accompanying drawings. Descriptions of well-known components, embodiments, materials, chemicals, manufacturing mechanisms, processing techniques, uses, and the like are omitted so as not to unnecessarily obscure the relevant details. It should be understood, however, that the detailed description and specific examples, while illustrating aspects of the present disclosure, are given by way of illustration only and not by way of limitation. Various substitutions, modifications, additions, and / or arrangements within the spirit and / or scope of the underlying inventive concept will be apparent to those skilled in the art from this disclosure.

[0065] As used throughout this disclosure, approximation may be applied to modify any quantitative expression that may be acceptably varied without resulting in a change in the underlying function to which it pertains. Thus, values ​​modified by one or more terms such as "substantially," "approximately," "about," "relatively," or other such similar terms are not limited to the exact value specified, but are used to describe and account for small variations from a reference or parameter, such as those due to processing variations. Such small variations include zero variation from a reference or parameter. For example, these terms may refer to ±5% or less, e.g., ±2% or less, e.g., ±1% or less, e.g., ±0.5% or less, e.g., ±0.2% or less, e.g., ±0.1% or less, e.g., ±0.05% or less. In some cases, approximation may correspond to the precision of the instrument used to measure the value.

[0066] The terminology used herein is for the purpose of describing particular examples only and is not intended to be limiting. As used herein, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly dictates otherwise. Furthermore, references to "one example" are not intended to be interpreted as excluding the existence of additional examples that also incorporate the recited features. Furthermore, unless expressly stated to the contrary, the terms "comprising" (any form of "comprise" such as "comprises", "comprising"), "have" (any form of "have" such as "has", "having"), "include" (any form of "include" such as "includes", "including"), and "contain" (any form of "contain" such as "contains", "containing") are used as open-ended linking verbs. Consequently, any instance of "comprising", "having", "including" or "containing" one or more steps or elements includes, but is not limited to, having such one or more steps or elements. As used herein, "may" and "may be" are used interchangeably. The term "may" and "may be" indicate the modification of another verb by expressing the possibility of occurring within a set of circumstances, the possession of a particular property, characteristic, or function, and / or the ability, possibility, or likelihood associated with the modified verb. Thus, the use of "may" and "may be" indicates that the modified term is clearly appropriate, possible, or suitable for the indicated ability, function, or usage, while taking into account that in some circumstances the modified term may not be appropriate, possible, or suitable.For example, in some circumstances an event or capability may be expected, but in other circumstances the event or capability may not occur - this distinction is captured by the terms "may" and "may be."

[0067] As used herein, unless otherwise specified, the term "whole" (and any other form of "whole") means at least a substantial portion, such as at least 95% or at least 99%. As used herein, the term "whole" (and any other form of "whole"), unless otherwise specified, is not thereby limited to 100%.

[0068] The terms "disinfectant," "sanitizer," and "sterilizer" (and their equivalents) are used interchangeably herein and refer to the act of capturing, removing, killing, or inhibiting the growth and / or reproduction of pathogens (i.e., infectious disease-causing microorganisms such as various viruses, bacteria, fungi, parasites, etc.). Similarly, the terms "disinfectant," "sanitizer," "sterilant," "antibacterial agent," and "antiseptic" (and their equivalents) are used interchangeably herein and refer to substances that disinfect (i.e., capture, remove, kill, or inhibit the growth and / or reproduction of pathogens). Such agents may be "topical" in that they disinfect pathogens located on one's skin or the exterior / exterior surface of an object.

[0069] Terms such as "affix," "connect," "contact," and "coupled" are broadly defined herein to encompass a variety of arrangements and assembly techniques. These arrangements and techniques include, but are not limited to, (1) direct joining of one component to another with no intervening components (i.e., the components are in direct physical contact); and (2) joining of one component to another with one or more components therebetween, provided that one component is "affixed," "connected," "contact," or "coupled" to the other component while still in operative communication with the other component in some manner (despite the presence of one or more additional components between them). It should be understood that some components that are in direct physical contact with each other may or may not be in fluid contact with each other. Furthermore, two components that are fluidly / fluidly connected, fluidly / fluidly coupled, or in fluid / fluid communication may or may not be in direct physical contact, and one or more other components may be disposed between them.

[0070] The present disclosure provides on-demand medication (e.g., disinfectant) dispensing devices and kits, and related methods utilizing such devices and kits, that can be removably affixed to an object (such as a user or the surface of an inanimate object) providing easy and available access to a supply of medication over an extended period of time. The devices are configured as patches that are configured to efficiently deliver medication on demand via applying pressure to the patch or compressing the patch across its thickness (and along its length, such as in a wiping or swiping motion / path).

[0071] On-demand drug dispensing patches provide a simple and cost-effective method for dispensing medication. The patches are self-contained and can be used with any medication that can be applied to a "dry" patch, providing a spill-free dispensing solution without the need to pour or spray the medication before each application or dispensing. In some embodiments, the patch may be configured to be removably attached to a user, such as to the user's skin or the user's clothing (or any other inanimate object carried or worn by the user). In such a configuration, the on-demand drug dispensing patch provides a wearable device for dispensing medication. The on-demand drug dispensing wearable device may be configured to be removably attached to a contact area of ​​a user or subject that would benefit from having a medication thereon, such as the inside of a user's hand (e.g., to the palm and / or fingers), where the medication is an antiseptic. In this manner, an active on-demand drug dispensing wearable patch can be applied to an "active" area of ​​a user (e.g., the user's elbow, palm, fingers, etc.) or subject, replacing that area with the outer surface of the patch.

[0072] In some embodiments, an on-demand drug dispensing patch may be wearably configured to be removably affixed to a passive portion of a user's skin (or an object worn / carried by the user) (or onto an inanimate object remote from the user) spaced from the user's contact point / portion to enable selective application of the drug via contact with the outer surface of the patch by the user pressing / compressing the patch. For example, a passive on-demand drug dispensing wearable patch may be removably affixed to the back of a user's hand, forearm, or clothing, allowing the user to swipe their finger / hand over the exposed outer surface of the patch to dispense the drug thereon. In such passive dispensing embodiments, the on-demand drug dispensing wearable patch provides rapid, discrete, on-demand access to a drug whereby swiping / contacting the device dispenses the drug onto a person's contact point / portion (e.g., hand or other skin surface).

[0073] The on-demand drug dispensing patches disclosed herein can thereby be applied to an active or passive surface portion of a user (or object) to provide a drug thereon. In this manner, if the drug is a disinfectant, the on-demand dispensing patch can provide a quantity / level of disinfectant to the user.

[0074] 1-6 illustrate an exemplary medication dispensing patch device 10 according to the present disclosure. As noted above, the medication may be any liquid or gelatinous medication that benefits or lends itself to being available on demand over a period of time and dispensed in doses or relatively small amounts. For example, the patch device 10 may be used with a liquid or gelatinous sanitizing / disinfecting medication (i.e., a germicide or disinfectant) such that the germicide / disinfectant is available to the user on demand or for extended periods of time and can be easily and quickly dispensed in large quantities for use from the patch device 10 without the need to open or otherwise access a container or package of the germicide / disinfectant.

[0075] As shown in Figures 1-3, in some embodiments, the on-demand drug dispensing patch device 10 may be a flexible patch configured to contain a drug and provide on-demand dispensing of the drug by compressing the patch across its thickness.

[0076] As shown in FIGS. 1-3 , in some embodiments, an on-demand drug dispensing patch device 10 can include at least one reservoir-dispensing portion or layer 11 and at least one attachment portion or layer 14. The attachment layer 14 can extend below or be located below the reservoir-dispensing portion 11. The reservoir-dispensing portion 11 can thereby extend over the attachment layer 14 in a thickness direction, such that a top outer exposed surface 20 of the reservoir-dispensing portion or layer 11 forms a top outer exposed surface of the patch device 10 to which the drug is applied, and the reservoir-dispensing portion 11 can be configured to absorb the drug. The on-demand drug dispensing patch device 10 can further include at least one backer layer 40 disposed in a thickness direction between the adhesive layer 14 and the reservoir-dispensing portion 11, as shown in FIGS. 1-3 . The backer layer 40 may be impermeable to the drug such that the backer layer 40 prevents the drug from interacting with the attachment layer 14. As described further below, the adhesive layer 14 may include an adhesive layer, whereby the backer layer 40 may prevent the drug from degrading or interfering with the adhesive. Additionally, the backer layer 40 may prevent the drug from penetrating the thickness of the patch device 10 and interacting with an object to which the patch device is attached, thereby helping to retain or contain the drug within the reservoir-dispenser portion 11. The backer layer 40 may also provide a consistent, solid surface for application to bond with the attachment layer 14.

[0077] As will be further described below, the patch device 10 may provide a "dry" state to the user such that the reservoir-dispenser portion 11 (and other portions of the patch device 10) is free of absorbed drug. For example, the reservoir-dispenser portion 11 (and other portions of the patch device 10) may be completely free of drug. In such embodiments, the patch device 10 may form part of a device, system, or kit that includes the patch device 10 and a container of drug that is separate and distinct from the patch device 10, as will be further described below with reference to Figures 8 and 9.

[0078] In some other embodiments, the reservoir-dispenser portion 11 (and other portions of the patch device 10) may not have a drug absorbed therein, but the drug may be contained within a manually breakable encapsulation provided within or adjacent to the reservoir-dispenser portion 11, such that a user manually breaks the encapsulation to release the drug, allowing the reservoir-dispenser portion 11 to absorb the drug, which is contained within the reservoir-dispenser portion. The encapsulation may also be a manually breakable shell or envelope. For example, in one exemplary embodiment, the encapsulation may be, in whole or in part, a foil cover or envelope, a polymeric shell or container, or a combination thereof.

[0079] The attachment portion 14 may comprise an attachment surface or surface 15 configured to attach / couple (removably or fixedly) the patch device 10 to an object (e.g., a user's skin or an inanimate surface, as described above and further below). The rear surface 42 of the backer layer 40 may be coupled to and located over at least a portion of the front surface 18 of the attachment portion 14, as shown in FIGS. 1-3. Similarly, the rear surface 13 / 17 of the reservoir-dispenser portion 11 may be coupled to and located over at least a portion of the front surface 41 of the backer layer 40, as shown in FIGS. 1-3. The drug reservoir-dispenser portion 11 is configured to control the rate of dispensing (i.e., time release) of a quantity of drug to a user at its exposed outer dispensing surface portion 20 when the user compresses the drug reservoir-dispenser portion 11 in its thickness direction. In some embodiments, the drug reservoir dispenser portion 11 may be refillable after one or more dispenses by applying a quantity of drug to the exposed outer dispensing surface portion 20 to allow the drug reservoir dispenser portion 11 to absorb the applied quantity of drug.

[0080] The patch device 10 (e.g., the attachment portion 14, the backer layer 40, and the drug reservoir dispenser portion 11) may be of any size and any shape. In some embodiments, the patch device 10 may be relatively flat or thin across its thickness (e.g., comprising a patch, a sheet, or a similar configuration). In some embodiments, the size and / or shape of the patch device 10 may correspond to a particular surface / object to which it may be removably coupled. In this manner, the patch device 10 may be configured for a particular application (e.g., a shape and size for removably attaching to a particular object or body part of a user). The patch device 10 (e.g., the attachment portion 14 and the drug reservoir dispenser portion 11) may be relatively flexible, such as being easily pliable manually.

[0081] The attachment portion 14 can include an adhesive layer configured to removably couple the patch to a surface, the adhesive layer defining an inner or rear / attachment surface 15 of the patch device 10. As shown in FIGS. 1-3 , the attachment surface 15 of the attachment portion 14 can define the back or underside of the patch device 10 in use, such that the attachment surface 15 defines a rear attachment surface of the patch device 10 that is configured to abut or overlap another surface when the patch device 10 is coupled to it. In some embodiments, the attachment portion 14 can include an adhesive on (or forming) the attachment surface 15 that is configured to removably couple the patch device 10 to a surface.

[0082] In some embodiments, the attachment portion 14 may include an adhesive configured to removably couple the patch device 10 to an inanimate object and / or a user (e.g., a user's skin or clothing). In some such embodiments, the adhesive may include a pressure-sensitive adhesive (PSA). In some such embodiments, the attachment portion 14 may be configured to removably attach directly to a user's skin via a biocompatible (and / or medical-grade) adhesive, such as a biocompatible PSA and / or an alcohol-resistant adhesive. In some embodiments, the adhesive of the attachment portion 14 may include an acrylic adhesive, an epoxy adhesive, a styrene block copolymer adhesive, or a combination thereof. In some such embodiments, the adhesive of the attachment portion 14 may include an acrylate, such as a methacrylate, an epoxy diacrylate (i.e., a vinyl resin), or a combination thereof. In some such embodiments, the adhesive attachment portion 14 may include an acrylic-based pressure-sensitive adhesive. In some embodiments, the adhesive of the attachment portion 14 may include spirit gum (mastic), matte spirit gum, liquid latex, thickened latex, flexible collodion, or a combination thereof. In some such embodiments, the adhesive may include a biodegradable, natural, and / or organic adhesive. In some embodiments, the tackiness, adhesion, shear strength, and breathability of the adhesive of the attachment portion 14 may be configured such that the patch device 10 is biocompatible with the user's skin.

[0083] In some embodiments, the attachment portion 14 may be formed from an adhesive that covers, surrounds, or is otherwise integrated with a scrim layer. The adhesive-scrim structure can form an integral adhesive-scrim layer that is disposed or applied to the rear surface 42 of the backer layer 40 or the rear surface 13 / 17 of the drug reservoir-dispenser portion 11 and bonded thereto via an adhesive.

[0084] In some other embodiments (not shown), the attachment portion 14 can include a mechanical mechanism and / or physical configuration that operates to removably attach the device to a surface or object. For example, the attachment portion 14 can include and / or comprise a strap, a hook-and-loop fastener (or hook-and-loop fastener), a snap fastener, a button, a strap, elastic, a suction cup / member, a zipper, a threaded post / opening, a magnet, or any other fastening mechanism configured to removably couple the patch device 10 to another surface / object. In some embodiments, the attachment portion 14 includes a clip or flap member extending from the rear surface. It should be noted that the particular design and configuration of the attachment portion 14 can take any form with respect to a particular surface / object sufficient to removably couple the patch device 10 to the surface / object.

[0085] As shown in FIGS. 2 and 3 , in some embodiments, the patch device 10 can include a removable attachment protective film or liner 30 that extends over the rear surface 15 of the attachment layer 14. The inner surface 32 of the attachment protective liner 30 can be configured to cover and protect the attachment layer 14 prior to use (or when not in use), as shown in FIGS. 2 and 3 . As also shown in FIGS. 2 and 3 , the outer or rear surface 31 of the protective liner 30 can define the outer rear surface of the patch device 10 prior to application to a surface (object / person). This allows the protective liner 30 to be configured to be manually removed from the adhesive layer 14 (e.g., peeled off) such that the adhesive layer 14 remains bonded to the patch device 10 and is effective to bond the patch device 10 to the surface. In some embodiments, the protective liner 30 can comprise a plastic / polymer, a coated paper, a metal / metallized layer (e.g., a foil layer or an aluminized material layer), or a combination thereof. In some embodiments, the protective liner 30 may include a tab to aid in manually removing (e.g., peeling) the protective liner 30 from the mounting surface 15 of the adhesive layer 14, as shown in FIGS.

[0086] As previously mentioned, in some embodiments, the patch device 10 can include at least one backer layer or film 40 disposed between the attachment layer 14 and the drug reservoir-dispenser portion 11 in the thickness direction, as shown in FIGS. 1-3. The at least one backer layer 40 can be substantially impermeable to the drug. The backer layer 40 can support an attachment mechanism 14 (e.g., adhesive and / or mechanical fasteners) (i.e., the attachment mechanism can be bonded to the bottom / rear surface 15 of the backer layer). Furthermore, the drug reservoir-dispenser portion 11 can be bonded to and positioned over (e.g., positioned directly over) the top / upper surface of the backer layer 40, as shown in FIGS. 1-3.

[0087] In some embodiments, the backer layer 40 comprises at least one layer of fabric (woven or nonwoven), plastic, or latex. For example, the backer layer 40 can comprise a breathable fabric, such as a woven (or nonwoven) nylon, polyester, or Gore-Tex layer. In some embodiments, the backer layer 40 can be flexible and comprise a moisture-wicking and / or breathable fabric layer (particularly in embodiments of the patch device 10 intended for use directly on the user's skin, as described further below). In some other embodiments, the backer layer 40 can be substantially impermeable to the drug and air. In some embodiments, the backer layer 40 can comprise at least one solid sheet of material, such as a polymer layer, film, or sheet. In some such embodiments, the backer layer 40 can comprise a polyethylene or polypropylene layer, film, or sheet. In some embodiments, backer layer 40 may comprise at least one polyethylene layer, polypropylene layer, styrene layer, polyetheretherketone layer, acrylic layer, polyvinyl chloride layer, polyurethane layer, Teflon (polytetrafluoroethylene) layer, syrlyn layer, or combinations thereof. In some embodiments, backer layer 40 may have a thickness of 0.5 to 3 mm, for example, about 1 mm.

[0088] In some embodiments, the patch device 10 can include a dispenser protective liner, film, or layer (not shown) that extends over the top or outer dispensing surface 20 of the drug reservoir-dispenser portion 11. The inside of the dispenser protective liner can be configured to cover and protect the drug reservoir-dispenser portion 11 prior to use (or when not in use). The outside or top / front surface of the protective liner can define the outer front / top surface of the patch device prior to use of the patch device 10 (e.g., prior to dispensing and / or application of a drug applied to the drug reservoir-dispenser portion 11). The dispenser protective liner can thereby be configured to cover and protect the dispensing surface portion 20 prior to use (or when not otherwise in use). In some embodiments, the dispenser protective liner can include a plastic / polymer or a metal / metallized layer (and potentially an adhesive). Removal of the dispenser protective liner can thereby activate the patch device 10 for use.

[0089] In some embodiments, the dispensing surface portion 20 (and / or the outer surface of the protective film liner) may include visual and / or tactile indicia (not shown) or may be configured to allow visual and / or tactile indicia to be drawn or formed thereon. For example, the dispensing surface portion 20 (and / or the outer surface of the protective film liner) may include a logo, name, trademark, or other visual indicia that can enhance the aesthetic look and / or feel of the patch device 10. As another example, the outer surface of the cover or protective film liner may be configured as a paper, chalkboard, or whiteboard type configuration to allow personalization of the patch device 10. In some embodiments, the outer surface of the cover or protective liner 20 includes at least one of a visible light reflective material and an illumination device thereon. In some embodiments, the protective liner may include a tab to facilitate manual removal (e.g., peeling) of the protective liner from the patch device 10 / drug reservoir-dispenser portion 11.

[0090] The drug reservoir dispenser portion 11 can comprise one or more layers and / or multiple materials. In some embodiments, the drug reservoir dispenser portion 11 may comprise a single layer made up of one or more materials. In some other embodiments, as discussed above and further below, the drug reservoir dispenser portion 11 can comprise one or more reservoir layers or portions 12 and one or more dispenser layers or portions 16 that are separate and distinct from the one or more drug reservoir layers or portions 12.

[0091] As shown in FIGS. 1-3 , in some embodiments, the drug reservoir dispenser portion 11 of the patch device 10 can include a dispenser layer 16 extending over at least one reservoir layer 12. The reservoir layer 12 is configured to absorb and retain a drug therein and is positioned across the mounting layer 14 in a thickness direction. The dispenser layer 16 may be positioned across the reservoir layer 12 in a thickness direction, as shown in FIGS. 1-3 . The dispenser layer 16 may include a plurality of solid portions and an array of a plurality of apertures extending through its thickness, and may be configured to inhibit evaporation of the drug when contained within the at least one reservoir layer 12 and control the flow of the drug from the drug reservoir dispenser portion 11 (particularly the reservoir layer 12) upon compression across the thickness of the patch device 10. The solid portion of the at least one dispenser layer 16 and the portion of the at least one reservoir layer 12 underlying the plurality of openings in the at least one dispenser layer 16 may define the outer surface 20 of the patch device 10 (when a protective liner is removed, if provided).

[0092] The medicament reservoir-dispenser portion 11 is configured to contain a quantity of medicament. For example, the medicament may be absorbed in the medicament reservoir-dispenser portion 11 (e.g., the medicament reservoir-dispenser portion 11 may comprise an absorbent pad, layer, or portion). As another example, the medicament reservoir-dispenser portion 11 may form at least one cavity, opening, or cell that contains the medicament. The medicament reservoir-dispenser portion 11 is also configured to dispense the medicament at the dispensing surface portion 20 to a user who compresses the die 10, such as by wiping a portion of the dispensing surface portion 20. At least a portion of the medicament reservoir-dispenser portion 11 thereby automatically controls the rate and duration of release / flow of the medicament at / to the outer dispensing surface portion 20 (and thereby to the user on demand). For example, the drug reservoir dispenser portion 11 may be configured to draw or otherwise provide a portion of a quantity of drug at or to the dispensing surface portion 20 so that when a user touches or wipes the dispensing surface portion 20, a portion of the drug is transferred to the user.

[0093] In some embodiments, the reservoir and dispensing functions or processes of the drug reservoir-dispenser portion 11 may be accomplished by a common layer or portion of the drug reservoir-dispenser portion 11. In some other embodiments, the reservoir and dispensing functions or processes may be accomplished by different layers or portions of the drug reservoir-dispenser portion 11.

[0094] As described above and shown in FIGS. 1-3 , in some embodiments, the drug reservoir dispenser portion 11 may include at least one reservoir layer or portion 12 configured to absorb and retain drug therein. In some embodiments, at least one reservoir layer or portion 12 may include a nonwoven absorbent fabric layer. For example, in one embodiment, at least one reservoir layer 12 may be formed from a fabric layer of nonwoven polymer fibers, such as nonwoven polyethylene and / or polypropylene fibers. In some embodiments, at least one reservoir layer or portion 12 may include a natural or synthetic nonwoven fabric layer. At least one reservoir layer 12 may include one or more layers of polymer fibers, cotton fibers, silicone fibers, hydrogels, or combinations thereof. In some embodiments, at least one reservoir layer or portion 12 may include one or more layers of fabric, Gore-Tex, gauze, absorbent gel, polymers, paper, foam, or combinations thereof.

[0095] In some embodiments, at least one reservoir layer or portion 12 may be formed from a fabric or textile (e.g., a layer / portion of cotton, nylon, polyester, etc.), Gore-Tex, gauze, absorbent gel (e.g., hydrogel), flash-spun high-density polyethylene (e.g., Tyvek), porous / filter paper, plastic film, foam, hydrocolloid, alginate, polysaccharide paste, granules and / or beads, or a combination thereof. For example, in some embodiments, reservoir portion 12 may comprise one or more layers of cotton, polyester, silicone, polyurethane, polyamide, polyethylene, hydrogel, or a combination thereof. In some such embodiments, reservoir portion 12 may include a cotton fabric layer or portion, a nylon fabric layer or portion, a polyester fabric layer or portion, a flash-spun high-density polyethylene fiber layer or portion, a hydrogel layer or portion, a flexible polyamide netting coated with a silicone layer or portion, a hydrogel layer or portion formed from a hydrophilic polymer, or a combination thereof.

[0096] In some embodiments, the at least one reservoir layer or portion 12 may be configured to absorb and retain drug in the range of about 2 grams to about 50 grams and / or have a detached agent capacity in the range of about 1,000 g / mm to about 2,500 g / mm. In some embodiments, the at least one reservoir layer 12 comprises a drug absorption rate of at least 5 g / sec for at least the first 5 seconds of water contact. The at least one reservoir layer or portion 12 may be configured such that, as the drug is contained / absorbed therein, a compressive force of at least 1 gram / mm applied to the outer dispensing surface 20 of the patch device 10 acting through its thickness causes the drug to flow from the at least one reservoir layer or portion 12 onto the outer dispensing surface 20 (potentially a trough opening in the outer dispenser layer 16, as further described below) and / or onto an object on the outer dispensing surface 20.

[0097] As discussed above and shown in FIGS. 1-3, in some embodiments, the drug reservoir dispenser portion 11 can comprise at least one dispenser layer or portion 16 comprising a plurality of solid portions and a plurality of openings or an array of openings extending through its thickness, the at least one dispenser layer 16 configured to inhibit evaporation of the drug when contained within the at least one reservoir layer and to control the flow of the drug from the at least one reservoir layer 12 upon compression through the thickness of the patch device 10.

[0098] The at least one dispenser layer 12 may comprise at least one perforated or microporous film or layer. In some embodiments, the at least one dispenser layer 12 comprises a sheet or layer of drug-impermeable and / or air-impermeable material. In some embodiments, the at least one dispenser layer 12 comprises a polymer layer. In some embodiments, the at least one dispenser layer 12 comprises at least one polyethylene layer, polypropylene layer, styrene layer, polyetheretherketone layer, acrylic layer, polyvinyl chloride layer, polyurethane layer, Teflon (polytetrafluoroethylene) layer, syrlyn layer, or combinations thereof.

[0099] In some embodiments, the solid portion of the at least one dispenser layer 12 may comprise between about 10% and about 65% of the total area of ​​the outer dispensing surface / side 20 of the patch device 10. In some embodiments, the plurality of openings in the at least one dispenser layer 12 comprise a total area between about 50 mm and about 300 mm on the outer dispensing surface / side 20 of the patch device 10. In some embodiments, each of the plurality of openings in the at least one dispenser layer 12 comprises a total area between about 0.05 mm and about 0.3 mm on the outer dispensing surface / side 20 of the patch device 10.

[0100] At least the dispensing portion 12 of the drug reservoir dispenser portion 11 may be configured to control the amount and / or rate at which drug is moved or drawn (e.g., via capillary action) and the dispensing surface portion 20, whereby the drug reservoir dispenser portion 11 is configured to meter / control the release or dispensing of drug to / from / at the dispensing surface portion 20. For example, at least one of the hole / perforation size, hole / perforation number / number, density and thickness of the at least one dispenser layer 12 and the capillary action of the drug reservoir dispenser portion 11 may be configured to control the amount and / or rate at which drug is moved into the at least one reservoir layer / portion and the at least one dispenser layer 16 or drawn through the at least one reservoir layer / portion 12 and the at least one dispenser layer and into the dispensing surface portion 20. The drug reservoir dispenser portion 11 may be configured to allow a specific dose of drug to flow through the drug reservoir dispenser portion 11 and the dispensing surface portion 20 when a specific pressure (e.g., a specific magnitude, area, direction, etc.) is applied by the user so that a specific dose of drug is thereby transmitted to the dispensing surface portion 20 (and thus to the user or surface applying the compression / pressure).

[0101] In some embodiments, a patch device 10 (formed from a drug reservoir-dispenser portion 11 (e.g., comprising at least one reservoir layer / portion 12 and at least one dispenser layer / portion 16), at least one backer layer / portion 40, and at least one attachment layer / portion 14) saturated with a liquid or gelatinous drug, such as those disclosed herein, is configured so that the drug is available / dispensable on the dispensing surface portion 20 upon contact or swiping of the dispensing surface portion 20 by a user for at least 2 hours, at least 3 hours, at least 4 hours, at least 5 hours, or at least 6 hours after the dispensing surface portion 20 is first exposed to air. In some embodiments, the patch device 10 is configured so that when a liquid or gelatinous drug, such as those disclosed herein, is absorbed into the at least one reservoir layer 12, no more than 5 grams of the drug evaporates over 1.5 hours in an ambient environment of non-moving / stagnant air at 20°C.

[0102] The agent may be any biocompatible disinfectant (i.e., safe and effective for use with humans, such as human skin), such as any topical disinfectant effective in killing and / or preventing the reproduction of disease-causing pathogens (e.g., viruses and bacteria) upon physical interaction between the agent and the pathogen. The agent may be effective for disinfecting human skin, as well as inanimate surfaces (e.g., surfaces including plastic, metal, glass, paper, cardboard, etc.). For example, the agent may include an alcohol disinfectant and / or a non-alcohol disinfectant. In some embodiments, the agent may include a disinfectant including ethyl, isopropyl, ethanol (ethyl alcohol), triclosan, triclocarban, benzalkonium chloride, benzethonium chloride, or a combination thereof. In some embodiments, the agent may include a disinfectant including ethanol (ethyl alcohol). In some embodiments, the agent may have a kinematic viscosity at 20 degrees Celsius within the range of about 4 (Pa·s) (m² / s) to about 15 (Pa·s) (m² / s). In some embodiments, the agent may include a medicine or vitamin, an insecticide, a fragrance, a food, a cleaning product, a paint, and / or an oil.

[0103] In some embodiments, the agent comprises ethyl, isopropyl, ethanol (ethyl alcohol), triclosan, triclocarban, benzalkonium chloride, benzethonium chloride, or a combination thereof. In some embodiments, the agent comprises 1,2-hexanediol, ammonium bicarbonate, ammonium carbonate, benzalkonium chloride, benzalkonium chloride, chlorine dioxide, citric acid, dodecylbenzenesulfonic acid, ethanol, ethyl, glutaraldehyde, glycolic acid, hydrochloric acid, hypochlorous acid, isopropyl, isopropanol, lactic acid, L-lactic acid, octanoic acid, peroxyacetic acid, peroxyoctanoic acid, phenol, potassium peroxymonosulfate, quaternary ammonium, silver, silver ions, sodium carbonate, sodium carbonate peroxyhydrate, sodium chloride, sodium chlorite, sodium dichloroisocyanurate, sodium dichloroisocyanurate dihydrate, sodium dichloroisocyanurate dihydrate, dichloro-S-triazinetrione sodium, sodium hypochlorite, thymol, triethylene glycol, triclosan, triclocarban, alcohol (e.g., at least 60% by volume), aloe oil, vinegar, an aromatherapy compound, or a combination thereof. In some embodiments, the agent may include at least one essential oil, such as geranium, lavender, sweet marjoram, neroli, palmarosa, peppermint, petitgrain, rose, tea tree, thyme, linalool oil, or a combination thereof. In some embodiments, the agent may be in liquid or gel form. In some embodiments, the agent may include a solution and / or a suspension, and may include at least a solid disinfectant.

[0104] While embodiments of the presently disclosed on-demand dispensing device (and associated methods) are described with respect to containing and dispensing disinfectant (i.e., on-demand disinfectant dispensing device), it is also specifically disclosed herein that the device may equally be used to dispense any other solid, liquid, or gel material. For example, the device may contain and be configured to dispense any pleasant or foul-smelling and / or flavorful material (e.g., bug or insect repellent, etc.). As another example, the device may contain and be configured to dispense skin lotion (e.g., moisturizer, sunscreen, etc.), antiperspirant / deodorant, medication / medication, lubricant, friction-enhancing material (e.g., sticky or gritty material), any other biocompatible material, biohazard material, or combinations thereof. In some such embodiments, the pharmaceutical / medicinal product may be a medicine, a vitamin (such as vitamin C, B12, etc.) or supplement (e.g., caffeine, nicotine, etc.), a cannabinoid (e.g., cannabidiol (CBD)), delta-9-tetrahydrocannabinol (THC), or a food product (e.g., sugar, candy, etc.). As a further example, the device may contain paint and be configured to dispense paint. As another example, the device may contain cleaning products and be configured to dispense cleaning products. As another example, the device may contain food or foodstuffs and be configured to dispense food or foodstuffs.

[0105] The layers or portions of the patch device 10 may be bonded to one another via any means, such as any mechanical and / or chemical modes or methods. In some embodiments, the layers or portions of the patch device 10 are adhered to one another. In some embodiments, the layers or portions of the patch device 10 are bonded to one another. In some such embodiments, the layers or portions of the patch device 10 are bonded to one another via the materials that make up the layers or portions. For example, in some embodiments, at least some of the adjacent layers or portions of the patch device 10 may be bonded to one another via layers or portions that are heated above their melting or softening points to become bonded to one another. In some such embodiments, the at least one reservoir layer 12 and the at least one dispenser layer 16, and / or the at least one reservoir layer 12 and the at least one backer layer 40 may be heat-sealed, radio frequency-sealed, and / or ultrasonically welded to one another. In some embodiments, when the at least one reservoir layer 12, the at least one dispenser layer 16, and / or the at least one backer layer 40 are formed of multiple overlapping layers, such layers may be bonded to one another.

[0106] 4-6, in some embodiments, the patch device 10 may be bonded or adhered together such that the peripheral portion 60 is compressed together relative to the interior or central portion of the patch device 10. This allows the peripheral portion 60 to define a total / maximum thickness T1 that is less than the thickness of the interior or central portion of the patch device 10. In some embodiments, the peripheral portion 60 may be formed by compressing and bonding at least one of the layers / portions of the patch device 10 together, such as via heat welding, radio frequency welding, and / or ultrasonic welding.

[0107] In some embodiments, the patch device 10 can define a total / maximum thickness T1 in the range of about 0.05 mm to about 3 mm, whereby the peripheral portion 60 can define a total / maximum thickness T1 that is less than 75%, e.g., about 50%, of the thickness of the interior or central portion of the patch device 10.

[0108] The perimeter of the patch device 10 can define any shape and size. For example, as shown in Figures 4 and 5, in one exemplary embodiment, the patch device 10 can define an oval or rectangular shape such that the length of the patch device 10 is greater than the width of the patch device 10 (e.g., a width in the range of 1 inch to 4 inches, and a length in the range of 1.5 inches to 10 inches). In some other exemplary embodiments (not shown), the patch device 10 can define a circular shape (e.g., having a diameter in the range of 1 inch to 4 inches, or in the range of 1 inch to 2.5 inches).

[0109] 7 and 8, a kit, system, or device according to the present disclosure may include one patch device 10 or may include multiple patch devices 10. Additionally, as previously discussed, one or more patch devices 10 may or may not include a drug incorporated therein. For example, one or more patch devices 10 may be completely devoid of a drug to be dispensed, or may be at least devoid of a drug absorbed in the reservoir-dispenser portion 11 (e.g., absorbed in at least one reservoir layer 12).

[0110] 7, in some embodiments, a kit, system, or apparatus according to the present disclosure may include multiple patch devices 10 mounted on or coupled to a substrate or carrier material 62. In some embodiments, the multiple patch devices 10 may be coupled to the substrate or carrier material 62 via their attachment portions 14 (e.g., adhesive layers). In some other embodiments, the multiple patch devices 10 may be coupled to the substrate or carrier material 62 via additional adhesives, members, or mechanisms.

[0111] As shown in FIG. 8 , in some embodiments, a kit, system, or device according to the present disclosure can include one or more patch devices 10 (e.g., multiple patch devices 10) and a reservoir 66 of a medication to be dispensed by the one or more patch devices 10. For example, as disclosed above, the medication can be a disinfectant / sanitizer. In such embodiments, one or more patch devices 10 can be provided lacking a medication, and the medication can be applied to the patch device 10 when an on-demand dispensing delivery of the medication is desired. For example, as shown in FIG. 9 , a “dry” patch device 10 lacking a medication can be attached or coupled, such as by adhesive, to a surface, and the medication reservoir 66 can be utilized by the user to apply a quantity of medication to the dispensing surface 20 such that the medication is absorbed into the reservoir-dispenser portion 11 (e.g., absorbed into at least one reservoir layer 12).

[0112] This allows the container 66 to be separate and distinct from one or more patch devices 10, allowing one or more patch devices 10 to be provided and stored prior to use, and the drug reservoir dispenser portion 11 (and other portions) of one or more patch devices 10 to be drug-free, such that no drug is absorbed into at least one reservoir layer 12 thereof.

[0113] In alternative embodiments, one or more reservoirs 66 of drug may be incorporated into each of the one or more patch devices 10 such that the drug is contained in and not absorbed by the at least one reservoir layer 12, but is configured such that release of the drug from the reservoir(s) causes the drug to flow into / be absorbed into the drug reservoir dispenser portion 11 (e.g., at least one reservoir layer 12). For example, the one or more reservoirs 66 of drug may be embedded within or located adjacent or near the drug reservoir dispenser portion 11 (e.g., at least one reservoir layer 12) of the patch device 10. Also, as previously mentioned, in such embodiments, the one or more reservoirs 66 may be manually rupturable or manually openable so that the drug can be selectively manually released from the one or more reservoirs 66.

[0114] After a quantity of drug has been provided onto the patch device 10 via the reservoir 66 and the drug (e.g., at least a majority thereof) has been absorbed into the drug reservoir dispenser portion 11 (e.g., into at least one reservoir layer 12), a user can compress the patch device 10 in its thickness direction to force a specific dose or amount of drug from the drug reservoir dispenser portion 11 toward the user at the dispensing surface 20. For example, as shown in FIG. 10 , a user can compress and “crunch” the device patch 10 via their hand to which the patch device 10 is coupled. It should be noted that such a movement / method can also rupture encapsulated drug contained in / on the patch device 10, releasing the drug into the drug reservoir dispenser portion 11 and dispensing the drug.

[0115] 11, a user can swipe the dispensing surface 20 to compress the length of the patch device 10 in the thickness direction, forcing a specific dose or amount of medication from the medication reservoir dispenser portion 11 to the user at the dispensing surface 20. In such a manner, the patch device 10 may be coupled to a surface away from the user's hand (e.g., a part of the user, such as the user's forearm, as one example), and the user can use their hand to swipe the patch device 10 to dispense an amount of medication from the patch device 10.

[0116] In some embodiments, the patch device 10 may be configured to be coupled to a user on passive clothing (e.g., a hat, shirt, coat, pants, belt, shoes, scarf, gloves, socks, etc.) or another inanimate object (e.g., sweatband, kinesiology / muscle tape, heating / cooling pad, helmet, protective pad / brace / splint / cast, headphones, luggage, personal accessories, baggage, wallet, handbag / purse, athletic equipment, etc.) configured to couple to a user (i.e., worn or carried by a user). The patch device 10 may thereby be removably coupled to a passive portion of a user that is spaced apart from a contact point / portion of the user where the user wishes to apply medication via contact with the dispensing surface portion 20. As previously mentioned, the attachment portion 14 may include an adhesive or mechanical connection mechanism configured to attach to a specific or general surface, such as clothing or another inanimate object attached / coupled to the user. In use, a user may thereby removably couple the patch device 10 to the user's clothing or another inanimate object coupled to the user on a passive portion of the user (for example, but not limited to, over the user's forearm, upper arm, chest, waist, or thigh), and when the user desires to apply a medication (e.g., disinfect), the dispensing surface portion 20 may be touched or wiped with one or more hands. When the user desires, the patch device 10 may be removed from the clothing or another inanimate object on / coupled to the user (preferably without damaging its outer surface).

[0117] Also as mentioned above, in some embodiments, the attachment portion 12 (and possibly the reservoir-dispenser portion 11) may be configured to allow the patch device 10 to be worn directly by a user on the skin. Thus, the attachment portion 14 may be configured to be biocompatible with a person's passive skin, and the patch device 10 may be breathable or otherwise resistant to causing the user to sweat underneath the device 10. For example, the patch device 10 may be configured to have an "invisible" feel when attached to the user's skin. Thus, the patch device 10 may be removably coupled to the user's skin. In use, a user may thereby removably couple the patch device 10 directly to their skin (e.g., but not limited to, the user's hand, forearm, upper arm, or thigh) and touch or wipe the dispensing surface portion 20 with one or more of their hands when the user desires to apply an agent (e.g., antiseptic) to one or more of their hands (or another body part or inanimate object touched by the user's one or more hands). When desired by the user, the patch device 10 can be removed from the user's skin (preferably without scratching, irritating or otherwise damaging the skin).

[0118] In some exemplary embodiments, the patch device 10 may be configured (e.g., shaped and sized) to removably couple to and extend over (e.g., cover) at least a portion of the palm and / or at least one finger of a user's hand. As another example, in some embodiments, the patch device 10 may be configured (e.g., shaped and sized) to removably couple to and extend over (e.g., cover) only a portion of the palm of a user's hand, as shown in FIG. 10 . In some other exemplary embodiments, the patch device 10 may be configured (e.g., shaped and sized) to removably couple to and extend over (e.g., cover) at least a portion of the inside of a finger of a user's hand. As another example, in some embodiments, the patch device 10 may be configured (e.g., shaped and sized) to removably couple to and extend over (e.g., cover) only a portion of the forearm of a user's arm, as shown, for example, in FIGS. 9 and 11 . In some other exemplary embodiments, the patch device 10 may be configured (e.g., shaped, dimensioned) to removably couple to and extend over (e.g., cover) at least a portion of the elbow of a user's arm.

[0119] In yet another embodiment, patch device 10, including at least attachment portion 14, may be configured to be attached to an inanimate object (not shown) that is not worn or carried by a user. For example, attachment portion 14 may be configured to be removably (or permanently) attached to a handle, knob, switch, armrest, seat, steering wheel, transmission / shift lever, exercise equipment, medical equipment, office equipment, cooking equipment, military / defense equipment, packaging (e.g., shipping or product packaging), furniture, pet products, or any other item or surface that is common (i.e., likely to be touched by multiple people) or located in or near a common spatial area, surface, or item.

[0120] In some embodiments, the patch device 10 may be configured such that the appearance of a portion of the patch device 10, such as the dispensing surface portion 20, changes depending on the amount of drug in the reservoir-dispenser portion 11. In this manner, the patch device 10 can automatically visually and / or tactically indicate the specific amount of drug in the reservoir-dispenser portion 11 available to the user via the dispensing surface portion 20 at any particular time. Note that the patch device 10 may be configured to variably change color as the amount of drug changes, or may change color only once when the level of drug is at least substantially depleted and / or the level available to the user is insufficient (e.g., for disinfection). For example, the reservoir-dispenser portion 11 and / or the drug may be configured to change color with changes in temperature, pH, and / or its dryness / wetness (e.g., liquid vs. solid form). As the amount of drug in the reservoir-dispenser portion 11 decreases (e.g., by being dispensed to a user via the dispensing surface portion 20 and / or by evaporating (or otherwise changing state)), the temperature, pH, and / or dryness / wetness (e.g., liquid / solid state) of the reservoir-dispenser portion 11 and / or drug may change, causing, for example, a color change with respect to the materials / components / chemicals / additives of the reservoir-dispenser portion 11 and / or drug. In some embodiments, the reservoir-dispenser portion 11 and / or drug may be configured to change color over time, independent of the actual amount of drug. For example, the reservoir-dispenser portion 11 and / or drug may include a pigment, ink dye, etc. that degrades or absorbs over time and changes its color over time. In this way, the color of the patch device 10 can indicate to the user how long the patch device 10 has been used, thereby indicating the potential state of a certain amount of drug (e.g., the drug may evaporate over time).

[0121] As another example, the patch device 10 may be configured to change size, shape, surface texture and / or other physical dimensions / aspects of the patch device 10 as the amount of medication in the reservoir-dispenser portion 11 decreases to provide a tactile indication of that level. For example, the dispensing surface portion 20 may include raised bumps or the like that flatten / shorten as the amount of medication in the reservoir-dispenser portion 11 decreases.

[0122] Another exemplary on-demand dispensing device 110 configured as a pocket patch device 110 is shown in Figures 12-16. The device 110 of Figures 12-16 is substantially similar to the patch device 10 described above with respect to Figures 1-11, and therefore like reference numerals beginning with "1" are used to indicate like components, aspects, layers, portions, features, processes, etc., and the above descriptions relating thereto apply equally and will not be repeated for purposes of brevity and clarity.

[0123] As shown in Figures 12-15, device 110 comprises a flexible drug-impermeable pocket 170 having a front or anterior surface 174, a posterior or rear surface 176, a lower end portion 175, an upper end portion 176, and lateral side portions 177 that define a drug-impermeable interior cavity or pocket 175 between the interiors of the front and rear surfaces, with lateral side portion 177 above lower end portion 175. This closes interior cavity 175 at lower end portion 175 and lateral side portions 177 (as well as at front and rear surfaces 174, 172), as shown in Figures 12-15. As also shown in Figures 12-15, drug-impermeable pocket 170 is open or reclosable at a top end or upper end portion 176 on pocket 170. This allows access to interior cavity 175.

[0124] Pocket 170 may be impermeable to medications (e.g., liquid or gelatinous medications) contained within interior cavity 175 (as described further below) such that a medication cannot flow or pass through front portion 174, rear portion 176, bottom portion 175, and lateral side portions 177. In some embodiments, pocket 170 may be impermeable to air such that air cannot enter (or pass through) interior cavity 175 through front portion 174, rear portion 176, bottom portion 175, and lateral side portions 177.

[0125] The pocket 170 may be formed from or comprise the same or similar materials as the backer layer 40 and / or the dispenser layer 16, as disclosed herein. For example, in some embodiments, the pocket 170 (e.g., the front portion 174, the back portion 176, the bottom portion 175, and the side portions 177) may be formed as a solid sheet of material. In some embodiments, the pocket 170 may be formed from or comprise a polymer layer or film. In some embodiments, the pocket 170 may be formed from or comprise at least one polyethylene layer, polypropylene layer, styrene layer, polyetheretherketone layer, acrylic layer, polyvinyl chloride layer, polyurethane layer, Teflon (polytetrafluoroethylene) layer, syrlyn layer, or a combination thereof.

[0126] In some embodiments, the front or surface 174 and / or the back or surface 176 may be a backer layer 40 of the device 10 described herein. In such embodiments, an additional backer layer 40, or two backer layers 40, 40, may be joined (e.g., bonded) to one another at their sides and bottom edges to form a flexible, drug-impermeable pocket 170.

[0127] 12-15 , at least one reservoir-dispenser portion or layer 111 may be coupled within the internal cavity 175 such that the dispensing surface portion 120 is exposed within the internal cavity 175. For example, a reservoir-dispenser portion 111 may be coupled to the inside of the front portion 174 within the internal cavity 175, and a reservoir-dispenser portion 111 may be coupled to the inside of the rear portion 172 within the internal cavity 175, or a first reservoir-dispenser portion 111 may be coupled to the inside of the front portion 174 within the internal cavity 175 and a second reservoir-dispenser portion 111 may be coupled to the inside of the rear portion 172 within the internal cavity 175. It should be noted that the reservoir-dispenser portions 111 may be coupled, bonded, and / or mechanically attached to the rear portion 172 and / or the front portion 174 via an adhesive. In some embodiments, a backer layer can be located / coupled between the reservoir-dispenser portion 111 and one of the rear portion 172 or front portion 174, respectively.

[0128] As explained in detail above, the reservoir-dispenser layer 111 is configured to absorb and retain a liquid or gelatinous agent therein and to control the flow of agent therefrom upon / through compression of the reservoir-dispenser layer 111 retained / absorbed therein. Also as mentioned above, the reservoir-dispenser portion 111 may be initially free of agent, or at least have no agent absorbed therein and applied from a separate and distinct container. As another example, the reservoir-dispenser portion 111 may not contain an absorbed agent therein, but the pocket patch device 110 may include an agent encapsulation or container that can be manually broken or otherwise opened to allow the agent to flow into and be absorbed by the reservoir-dispenser portion.

[0129] As shown in Figures 15A-15C, the pocket patch device 110 may be configured such that the internal cavity 175 is sized and shaped to allow at least one finger of a user to extend into the internal cavity 175 and engage the dispensing surface portion 120 in order to compress the reservoir-dispensing layer 111 and dispense a medication therefrom to the user. Also as shown in Figures 15A-15C, in some embodiments, the pocket patch device 110 may be configured such that the internal cavity 175 is sized and shaped to allow multiple fingers or the entire hand of a user to extend into the internal cavity 175 and engage the dispensing surface portion 120 in order to compress the reservoir-dispensing layer 111 and dispense a medication therefrom to the user's finger / hand.

[0130] 13 and 14 , the exterior of the pocket 170 can include an attachment layer or portion 114 (and optionally a liner layer protecting / covering the attachment layer or portion 114) configured to removably couple the pocket patch device 110 to a surface, as previously described. In some embodiments, the exterior or surface of the rear portion 172 can include an attachment portion 114 coupled thereto, as shown in FIGS. 13 and 14 . In some embodiments, the exterior or surface of the front portion 174 can include an attachment portion 114 coupled thereto. In some embodiments, the exterior or surface of the rear portion 172 can include a first attachment portion 114 coupled thereto, and the exterior or surface of the front portion 174 can include a second attachment portion 114 coupled thereto. As previously described, the attachment portion 114 can be, for example, an adhesive or a mechanical mechanism configured to removably couple the pocket patch device 110 to a surface.

[0131] In some embodiments, the top or upper end portion 176 of the pocket 170 may be configured to be initially closed (and potentially sealed) and then opened or unsealed. For example, as shown in FIG. 16 , the top portion 176 of the pocket 170 may include or comprise a closure structure. The closure structure may be sealed, or may be configured to be openable or simply openable such that the top portion 176 opens to the interior cavity 175.

[0132] 16 , in some embodiments, the closure structure 182 can include an openable closure 184. For example, the closure 184 can be a peel-and-stick closure or a zipper closure (e.g., single or double) that includes a mating hook-like channel or that includes a mating hook-like channel and a hook-like male member. The closure 184 can allow for selective manual opening / closing / sealing of the top end portion 176 for selective access to the internal cavity 175. The closure 184 can prevent the flow of medication and / or air through the top end portion 176 to / from the internal cavity 175.

[0133] 16 , the top portion 176 of the pocket 170 can have a seal 180 at its end that seals access to / from the top portion 176 and the internal cavity 175. As also shown in FIG. 16 , in some such embodiments, the top portion 176 can further include a non-sealing portion 182 disposed between the seal 180 and the internal cavity 175. The non-sealing portion 182 can be configured to be cut, broken, torn, or otherwise separated such that the seal can be selectively separated from the pocket 170 to open the top portion 176 and provide access to / from the internal cavity 175. It should be noted that the closure 184, the seal 180, and the non-sealing portion 182 can all be provided on the top portion 176.

[0134] It should be understood that the above description is illustrative, and not limiting. For example, the foregoing examples (and / or aspects thereof) can be used in combination with each other. Moreover, many modifications can be made to adapt a particular situation or material to the teachings of the various examples without departing from their scope. While dimensions and types of materials may be described herein, they are intended to define some parameters of the various examples and are by no means limiting to all examples, but are merely illustrative. Many other examples will be apparent to those skilled in the art upon reviewing the above description. The scope of the various examples should, therefore, be determined with reference to the claims appended hereto, along with the full range of equivalents to which such claims are entitled.

[0135] As used herein, the terms "comprises" and "in which" are used as plain English synonyms of the terms "comprising" and "wherein," respectively. Furthermore, as used herein, terms such as "first," "second," and "third" are used merely as reference labels and are not intended to impose numerical, structural, or other requirements. The term "based on" as used herein encompasses relationships in which an element is partially based and relationships in which an element is completely based. The term "defined by" as used herein encompasses relationships in which an element is partially defined and relationships in which an element is completely defined. Furthermore, claim limitations contained herein are not written in means-plus-function form and are not intended to be construed under the sixth paragraph of 35 U.S.C. § 112 unless and until such claim limitations expressly use the phrase "means" followed by a description of the functional cavity of further structure. It is understood that not all such objects or advantages set forth above may necessarily be achieved in accordance with any particular example. Thus, for example, it will be understood by those skilled in the art that the systems and methods described herein may be implemented or performed in a manner that achieves or optimizes one advantage or advantages taught herein without necessarily achieving other objectives or advantages that may be taught or suggested herein.

[0136] While the present disclosure has been described in detail in connection with only a limited number of examples, it should be readily understood that the present disclosure is not limited to such disclosed examples. Rather, the present disclosure can be modified to incorporate any number of variations, alterations, substitutions, or equivalent arrangements not heretofore described, but which are commensurate with the spirit and scope of the present disclosure. Furthermore, while various examples have been described, it should be understood that aspects of the present disclosure may include only one or some of the described examples. Also, while some disclosures are described as having a particular number of elements, it should be understood that examples can be practiced with fewer or more than the specified number of elements.

[0137] It is understood that all combinations of the foregoing concepts and additional concepts described in more detail below (to the extent such concepts are not mutually inconsistent) are considered to be part of the inventive subject matter disclosed herein. In particular, all combinations of claimed subject matter appearing at the end of this disclosure are considered to be part of the inventive subject matter disclosed herein.

Claims

1. a container containing a quantity of a liquid or gelatinous medicament; a flexible patch configured to contain the medication and to dispense the medication on demand by compressing the patch through its thickness; The patch comprises: an adhesive layer configured to removably couple the patch to a surface and defining an interior surface of the patch; at least one reservoir layer positioned over the adhesive layer in the thickness direction, the reservoir layer configured to absorb and retain the drug therein; at least one dispenser layer positioned over the at least one reservoir layer in a thickness direction, the dispenser layer having a plurality of solid portions and an array of a plurality of apertures extending through the thickness thereof, the dispenser layer configured to inhibit evaporation of the drug when contained within the at least one reservoir layer and to control flow of the drug from the at least one reservoir layer upon said compression of the patch in the thickness direction; at least one backer layer disposed between the adhesive layer and the at least one reservoir layer in the thickness direction, the backer layer being substantially impermeable to the drug; Equipped with the solid portion of the at least one dispenser layer and the portion of the at least one reservoir layer underlying the plurality of openings in the at least one dispenser layer define an outer surface of the patch; the at least one reservoir layer is free of the drug absorbed therein; On-demand liquid or gelatinous medication dispensing kit.

2. The kit of claim 1 , wherein the adhesive is a biocompatible adhesive.

3. 10. The kit of claim 1, wherein the patch further comprises an inner protective film layer extending over and removably bonded to the adhesive layer.

4. 10. The kit of claim 1, wherein the patch further comprises an outer protective film layer extending over and removably coupled to the outer surface of the patch.

5. The kit of claim 1 , wherein the patch further comprises a mechanical connector configured to removably attach the patch to a subject.

6. The kit of claim 1 , wherein the agent is a disinfectant.

7. The kit of claim 6 , wherein the disinfectant is a biocompatible disinfectant.

8. 7. The kit of claim 6, wherein the disinfectant comprises ethyl, isopropyl, ethanol (ethyl alcohol), triclosan, triclocarban, benzalkonium chloride, benzethonium chloride, or a combination thereof.

9. 7. The kit of claim 6, wherein the disinfectant comprises ethanol (ethyl alcohol).

10. 7. The kit of claim 6, wherein the disinfectant comprises a kinematic viscosity at 20 degrees Celsius in the range of about 4 (Pa·s) (m2 / s) to about 15 (Pa·s) (m2 / s).

11. The kit of claim 1 , wherein the agent comprises a drug or a vitamin.

12. The kit of claim 1 , wherein the agent comprises an insecticide.

13. The kit of claim 1 , wherein the agent comprises a fragrance.

14. The kit of claim 1 , wherein the medication comprises a food product.

15. The kit of claim 1 , wherein the agent comprises a cleaning agent.

16. The kit of claim 1 , wherein the agent comprises a paint.

17. The kit of claim 1 , wherein the agent comprises an oil.

18. 10. The kit of claim 1, wherein the at least one backer layer is substantially impermeable to the agent and air.

19. The kit of claim 1 , wherein the at least one backer layer comprises a solid sheet of material.

20. The kit of claim 1 , wherein the at least one backer layer comprises a polymer layer.

21. 21. The kit of claim 20, wherein the at least one backer layer comprises at least one polyethylene layer, polypropylene layer, styrene layer, polyetheretherketone layer, acrylic layer, polyvinyl chloride layer, polyurethane layer, Teflon (polytetrafluoroethylene) layer, syrlyn layer, or a combination thereof.

22. The kit of claim 1 , wherein the at least one dispenser layer comprises a sheet of material that is impermeable to the agent.

23. 23. The kit of claim 22, wherein the at least one dispenser layer comprises a sheet of air-impermeable material.

24. 24. The kit of claim 23, wherein the at least one dispenser layer comprises a polymer layer.

25. 25. The kit of claim 24, wherein the at least one dispenser layer comprises at least one polyethylene layer, polypropylene layer, styrene layer, polyetheretherketone layer, acrylic layer, polyvinyl chloride layer, polyurethane layer, Teflon (polytetrafluoroethylene) layer, syrlyn layer, or a combination thereof.

26. 23. The kit of claim 22, wherein the solid portion of the at least one dispenser layer comprises in the range of about 10% to about 65% of the total area of ​​the exterior surface.

27. The plurality of openings in the at least one dispenser layer are spaced apart from each other by about 50 mm from the outer surface. ２ ~Approx. 300mm ２ 27. The kit of claim 26, comprising an average total area in the range of:

28. Each of the plurality of openings in the at least one dispenser layer is about 0.05 mm from the outer surface. ２ ~Approx. 0.3mm ２ 27. The kit of claim 26, comprising a total area in the range of:

29. 10. The kit of claim 1, wherein the patch comprises a total / maximum thickness in the range of about 0.05 mm to about 3 mm.

30. 10. The kit of claim 1, wherein the at least one reservoir layer comprises one or more layers of fabric, Gore-Tex, gauze, absorbent gel, polymer, paper, foam, or combinations thereof.

31. 31. The kit of claim 30, wherein the at least one reservoir layer comprises one or more layers of polymer fibers, cotton fibers, silicone fibers, hydrogel, or combinations thereof.

32. 32. The kit of claim 31, wherein the at least one reservoir layer comprises a fabric layer of nonwoven polymeric fibers.

33. 33. The kit of claim 32, wherein the at least one reservoir layer comprises a layer of non-woven polyethylene and / or polypropylene fibers.

34. 31. The kit of claim 30, wherein the at least one reservoir layer comprises a natural or synthetic nonwoven layer.

35. 10. The kit of claim 1, wherein the at least one reservoir layer is configured to absorb and retain the agent in a range of about 2 grams to about 50 grams.

36. The at least one reservoir layer has a tensile strength of about 1,000 g / mm ２ ~Approx. 2,500g / mm ２ 36. The kit of claim 35, comprising a stripper volume in the range of

37. 37. The kit of claim 36, wherein the at least one reservoir layer comprises a drug absorption rate of at least 5 g / sec for at least the first 5 seconds of water contact.

38. When the drug is contained within the at least one reservoir layer, the patch operates in the thickness direction and has a force of at least 1 gram / mm applied to the outer surface thereof. ２ 2. The kit of claim 1, wherein the kit is configured such that a compressive force of 0.05% causes the agent to flow through the plurality of openings onto the exterior surface and / or onto an object on the exterior surface.

39. 2. The kit of claim 1, wherein an interior portion of the patch defines a first maximum thickness, and a peripheral edge portion of the patch extending around the interior portion and defining an outer extent of the patch defines a second thickness that is less than the first thickness.

40. 2. The kit of claim 1, wherein a peripheral edge portion of the patch defining an outer extent of the patch comprises the at least one reservoir layer, and the at least one dispenser layer and the at least one backer layer are joined to one another.

41. 41. The kit of claim 40, wherein the at least one reservoir layer, the at least one dispenser layer, and the at least one backer layer are heat, radio frequency, or ultrasonically welded to one another around the perimeter edge of the patch.

42. 10. The kit of claim 1, wherein when the drug is contained in the at least one reservoir layer, the patch is configured to evaporate no more than 5 grams of the drug over 1.5 hours in an ambient environment of non-moving air at 20 degrees Celsius.

43. The kit of claim 1 , wherein the adhesive comprises a biocompatible pressure-sensitive adhesive.

44. 44. The kit of claim 43, wherein the adhesive layer on the outer front surface comprises an acrylic pressure-sensitive adhesive.

45. 45. The kit of claim 44, wherein the adhesive layer comprises an adhesive and scrim layer construction.

46. The kit of claim 1 , wherein the container is separate and distinct from the flexible patch.

47. The kit of claim 1 , wherein the container is incorporated into or attached to the flexible patch.

48. 48. The kit of claim 47, wherein the quantity of agent is contained within a manually destructible shell or envelope.

49. 49. The kit of claim 48, wherein the shell or envelope is contained within the flexible patch or disposed adjacent to the at least one dispenser layer of the flexible patch.

50. a flexible drug-impermeable pocket having a front surface, a rear surface, a bottom end portion, a top end portion, side portions, and an internal cavity between the insides of the front surface and the rear surface, the internal cavity being closed at the bottom end portion and the side portions and open or openable at the top end portion, the impermeable pocket being impermeable to liquid or gelatinous drugs; at least one reservoir-dispenser layer disposed within the interior cavity of the pocket, the at least one reservoir-dispenser layer configured to absorb and retain a liquid or gelatinous medicament therein and to control flow of the medicament from the at least one reservoir layer upon compression of the at least one reservoir layer when the medicament is retained therein; An on-demand drug dispensing pocket device comprising:

51. 51. The device of claim 50, wherein the device further comprises an attachment mechanism on the exterior of the rear surface configured to couple the device to an object.

52. 52. The device of claim 51, wherein the attachment mechanism is configured to removably couple the device to an object.

53. 53. The device of claim 52, wherein the attachment mechanism comprises an adhesive layer located over at least a portion of the outer side of the rear face configured to removably couple the device to a surface.

54. 54. The device of claim 53, wherein the adhesive layer comprises a biocompatible adhesive.

55. 55. The device of claim 54, wherein the adhesive layer comprises an acrylic pressure sensitive adhesive.

56. 56. The apparatus of claim 55, wherein the adhesive layer comprises an adhesive and scrim layer structure bonded to the outer side of the rear surface via the adhesive.

57. 57. The device of claim 56, wherein the device further comprises a removable back liner layer extending over the adhesive layer to temporarily cover the adhesive layer.

58. 53. The device of claim 52, wherein the attachment mechanism comprises a clip or flap member extending from the rear surface.

59. 52. The device of claim 51, wherein the device further comprises an attachment mechanism on the exterior of the front surface configured to couple the device to an object.

60. 60. The device of claim 59, wherein the attachment mechanism on the exterior of the front surface is configured to removably couple the device to an object.

61. 61. The device of claim 60, wherein the attachment feature on the exterior of the front surface comprises an adhesive layer located over at least a portion of the exterior configured to removably couple the device to a surface.

62. 62. The device of claim 61, wherein the adhesive layer on the exterior of the front surface comprises a biocompatible adhesive.

63. 63. The device of claim 62, wherein the adhesive layer on the outer side of the front surface comprises an acrylic pressure sensitive adhesive.

64. 64. The apparatus of claim 63, wherein the adhesive layer on the outer side of the front surface comprises an adhesive and scrim layer structure bonded to the outer side of the front surface via the adhesive.

65. 65. The device of claim 64, further comprising a removable front liner layer extending over the adhesive layer to temporarily cover the adhesive layer on the outer side of the front surface.

66. 61. The device of claim 60, wherein the attachment mechanism on the exterior of the front surface comprises a clip or flap member extending from the rear surface.

67. 51. The device of claim 50, wherein the at least one reservoir layer includes a quantity of the agent absorbed and retained therein.

68. 51. The device of claim 50, wherein the at least one reservoir layer is free of the agent, the device further comprising a reservoir of the agent for selectively applying the agent to the inside of the at least one reservoir layer.

69. 51. The device of claim 50, wherein the agent comprises a disinfectant.

70. 70. The device of claim 69, wherein the disinfectant is a biocompatible disinfectant.

71. 71. The device of claim 70, wherein the antiseptic comprises ethyl, isopropyl, ethanol (ethyl alcohol), triclosan, triclocarban, benzalkonium chloride, benzethonium chloride, or a combination thereof.

72. 72. The device of claim 71, wherein the disinfectant comprises ethanol (ethyl alcohol).

73. 51. The device of claim 50, wherein the agent comprises a drug or a vitamin.

74. 51. The device of claim 50, wherein the agent comprises an insecticide.

75. 51. The device of claim 50, wherein the agent comprises a fragrance.

76. 51. The device of claim 50, wherein the medication comprises a food product.

77. 51. The device of claim 50, wherein the agent comprises a cleaning agent.

78. 51. The device of claim 50, wherein the agent comprises a paint.

79. 51. The device of claim 50, wherein the agent comprises an oil.

80. 51. The device of claim 50, wherein the agent comprises a kinematic viscosity in the range of about 4 (Pa.s) (m2 / s) to about 15 (Pa.s) (m2 / s) at 20 degrees Celsius.

81. 51. The device of claim 50, wherein the at least one reservoir dispenser layer comprises at least one dispenser layer having a plurality of solid portions and an array of a plurality of openings extending through its thickness, the at least one dispenser layer configured to inhibit evaporation of the agent and to control the flow of the agent from the at least one reservoir dispenser layer upon compression in the thickness direction of the at least one reservoir dispenser layer when the agent is contained within the at least one reservoir dispenser layer.

82. 82. The device of claim 81, wherein the at least one dispenser layer defines an innermost surface of the at least one reservoir-dispenser layer and is exposed to the interior cavity.

83. 83. The device of claim 82, wherein the at least one dispenser layer comprises a sheet of material that is impermeable to the agent.

84. 84. The device of claim 83, wherein the at least one dispenser layer comprises a sheet of air-impermeable material.

85. 85. The device of claim 84, wherein the at least one dispenser layer comprises a polymer layer.

86. 86. The device of claim 85, wherein the at least one dispenser layer comprises at least one polyethylene layer, polypropylene layer, styrene layer, polyetheretherketone layer, acrylic layer, polyvinyl chloride layer, polyurethane layer, Teflon (polytetrafluoroethylene) layer, syrlyn layer, or a combination thereof.

87. 87. The device of claim 86, wherein the solid portion of the at least one dispenser layer comprises in the range of about 10% to about 65% of the total area of ​​the exterior surface.

88. The plurality of openings in the at least one dispenser layer are spaced apart from each other by about 50 mm from the outer surface. ２ ~Approx. 300mm ２ 88. The device of claim 87, comprising an average total area in the range of:

89. Each of the plurality of openings in the at least one dispenser layer is about 0.05 mm from the outer surface. ２ ~Approx. 0.3mm ２ 89. The apparatus of claim 88, comprising a total area in the range:

90. 90. The device of claim 89, wherein the at least one reservoir-dispenser layer comprises at least one reservoir layer configured to absorb and retain the agent therein.

91. 91. The device of claim 90, wherein the at least one reservoir layer is located below the at least one dispenser layer.

92. 91. The device of claim 90, wherein the at least one reservoir layer comprises one or more layers of fabric, Gore-Tex, gauze, absorbent gel, polymer, paper, foam, or combinations thereof.

93. 91. The device of claim 90, wherein the at least one reservoir layer comprises one or more layers of polymer fibers, cotton fibers, silicone fibers, hydrogel, or combinations thereof.

94. 91. The device of claim 90, wherein the at least one reservoir layer comprises a fabric layer of nonwoven polymeric fibers.

95. 91. The device of claim 90, wherein the at least one reservoir layer comprises a layer of non-woven polyethylene and / or polypropylene fibers.

96. 91. The device of claim 90, wherein the at least one reservoir layer comprises a natural or synthetic nonwoven layer.

97. 91. The device of claim 90, wherein the at least one reservoir layer is configured to absorb and retain the agent in a range of about 2 grams to about 50 grams.

98. The at least one reservoir layer has a tensile strength of about 1,000 g / mm ２ ~Approx. 2,500g / mm ２ 98. The apparatus of claim 97, comprising a release agent volume in the range of

99. 99. The device of claim 98, wherein the at least one reservoir layer comprises a drug absorption rate of at least 5 g / sec for at least the first 5 seconds of water contact.

100. The at least one reservoir-dispenser layer has a thickness-wise applied force of at least 1 gram / mm applied to its exposed inner surface. ２ 100. The device of claim 99, wherein the device is configured such that a compressive force of 0.5 .mu.m causes the agent to flow therefrom and onto the exposed inner surface.

101. 91. The device of claim 90, wherein the at least one reservoir-dispenser layer comprises at least one backer layer underlying the at least one reservoir layer, the at least one backer layer being substantially impermeable to the agent.

102. 102. The device of claim 101, wherein the at least one backer layer is substantially impermeable to the agent and air.

103. 103. The apparatus of claim 102, wherein the at least one backer layer comprises a solid sheet of material.

104. 104. The device of claim 103, wherein the at least one backer layer comprises a polymer layer.

105. 105. The device of claim 104, wherein the at least one backer layer comprises at least one polyethylene layer, polypropylene layer, styrene layer, polyetheretherketone layer, acrylic layer, polyvinyl chloride layer, polyurethane layer, Teflon (polytetrafluoroethylene) layer, syrlyn layer, or a combination thereof.

106. 61. The device of claim 60, wherein the front and / or rear surfaces of the pocket are substantially impermeable to the agent.

107. 107. The device of claim 106, wherein the front and / or rear surfaces of the pocket are substantially impermeable to the agent and air.

108. 108. The apparatus of claim 107, wherein the front and / or rear surfaces of the pocket comprise solid sheets of material.

109. 109. The device of claim 108, wherein the front and / or rear surface of the pocket comprises a polymer layer.

110. 110. The device of claim 109, wherein the front and / or rear surfaces of the pocket comprise at least one polyethylene layer, polypropylene layer, styrene layer, polyetheretherketone layer, acrylic layer, polyvinyl chloride layer, polyurethane layer, Teflon (polytetrafluoroethylene) layer, syrlyn layer, or combinations thereof.

111. 51. The device of claim 50, wherein the at least one reservoir-dispenser layer comprises a total thickness in the range of about 0.05 mm to about 3 mm.

112. 51. The device of claim 50, wherein an inner portion of the at least one reservoir-dispenser layer defines a first maximum thickness, and an outer peripheral edge portion of the at least one reservoir-dispenser layer extending around the inner portion to define an outer extent of the at least one reservoir-dispenser layer defines a second thickness that is less than the first thickness.

113. 51. The device of claim 50, wherein the at least one reservoir-dispenser layer comprises at least one dispenser layer and at least one reservoir layer bonded together.

114. 114. The device of claim 113, wherein the at least one dispenser layer is positioned over the at least one reservoir layer, and the at least one reservoir layer is bonded to the interior or exterior surface.

115. 115. The device of claim 114, wherein the at least one reservoir layer, the at least one dispenser layer, and the interior or exterior surface are heat, radio frequency, or ultrasonically welded together around the outer periphery of the patch.

116. 116. The device of claim 115, wherein when the drug is contained within the at least one reservoir layer, the device is configured to evaporate no more than 5 grams of the drug over 1.5 hours in an ambient environment of non-moving air at 20 degrees Celsius.

117. 116. The device of claim 115, wherein the at least one reservoir-dispenser layer comprises multiple sub-layers bonded to one another.

118. 51. The device of claim 50, further comprising a quantity of the agent.

119. 119. The device of claim 118, wherein the quantity of drug is absorbed within the at least one reservoir-dispenser layer.

120. 119. The device of claim 118, wherein the quantity of medication is contained within a manually destructible shell or envelope.

121. 121. The device of claim 120, wherein the shell or envelope is contained within or disposed on the at least one reservoir-dispenser layer.

122. 122. The device of claim 121, wherein the device is configured as an on-demand drug dispensing pocket patch.

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