Cosmetic composition

Abstract

The present invention relates to a cosmetic composition comprising, as components, (A) a lipopeptide compound having a cyclic structure or a salt thereof, (B) glycerin, (C) a long-chain fatty acid having a branched structure, (D) isostearyl alcohol, and water, wherein the content of component (A) is more than 0% by mass and not more than 4% by mass, based on the total mass of the composition.

Description

[Technical Field]

[0001] The present invention belongs to the field of cosmetics, and specifically, the present invention relates to a cosmetic composition having good transparency and appearance as well as good permeability for physiologically active substances. [Background technology]

[0002] Cosmetic compositions for external use on the skin not only provide a good appearance (whitening, blemish concealment, artistic modification, etc.), but also can suppress skin imperfections, replenish skin nutrients, and improve or alleviate skin damage caused by superficial trauma or skin aging.

[0003] Therefore, in order to achieve skin health promotion and care effects, it is generally desirable to add functional ingredients, typically physiologically active substances, that are tolerated by the human body to external skin cosmetic compositions.

[0004] Furthermore, as a method for achieving the above-mentioned object, a mechanism similar to that of a transdermal delivery system, in which a topical skin preparation containing a functional ingredient is brought into contact with the skin to intentionally deliver the functional ingredient to a target site, has been considered or attempted. In this case, the functional ingredient is required to have not only good dispersibility but also good skin permeability.

[0005] It is also known that topical skin cosmetic compositions generally exist and are used as pure water-phase systems, pure oil-phase systems, or water-oil two-phase systems. In particular, to maintain the necessary stability in water-oil two-phase systems, surfactants are essential components that utilize the affinity of the water or oil phase to provide good emulsion stability to the dispersed phase particles in the emulsion.

[0006] Therefore, as a feasible attempt, the use of surfactants as auxiliary ingredients to improve the permeability and absorbability of functional ingredients (especially physiologically active ingredients) and pharmaceutical ingredients into human skin has been studied. For example, in cited document 1, sucrose fatty acid esters, which are nonionic surfactants with excellent biodegradability, low skin irritation, and excellent transdermal absorbability of molecular pharmaceutical compounds, are used as auxiliary ingredients to promote transdermal drug absorption.

[0007] Furthermore, surfactants with emulsifying properties are now required to have better emulsion stability, low toxicity, and environmental friendliness in cosmetic compositions for external use on the skin, and therefore, biologically derived surfactants are also gaining increasing attention.

[0008] Biologically derived surfactants are broadly classified into types such as lipopeptides, sugar esters, phospholipids, and other neutral lipids. Reference 2 discloses surfactin, a green biosurfactant with strong emulsifying properties. Obtained through biological fermentation, it has been verified to have excellent dispersibility and emulsion stability, as well as to be less irritating to the human body than other commonly used surfactants (such as SDS).

[0009] Furthermore, the transdermal permeation-enhancing effect of lipopeptides having a cyclic structure on physiologically active substances has also been confirmed in Reference 3, where a test using a Franz diffusion cell showed that the skin permeation rate of a physiologically active ingredient per 1% by weight of a lipopeptide compound or its salt was enhanced by more than two times compared to when the lipopeptide compound or its salt was not added.

[0010] On the other hand, in modern commerce, in addition to the pursuit of comfort and functionality during use, there is also a growing need for aesthetic appearance and personalization of the product for topical skin cosmetic compositions. Generally, cosmetics that give a refreshing and transparent impression are considered to be able to meet the preferences of consumers in many cases.

[0011] Although the above-mentioned research has been conducted in the prior art, there is still room for improvement in the properties such as functionality and appearance of cosmetic compositions for external use on the skin. Prior art documents References

[0012] Cited document 1:JP2003-238446A Reference 2: "Biosurfactants with Cyclic Peptide Structures," Zou Qingqing et al., "New Technology and New Products," February 2016 Cited document 3:JP5906194B2 Summary of the Invention [Problem to be solved by the invention]

[0013] As mentioned above, the use of lipopeptides having a cyclic structure, which have strong emulsifying properties, are environmentally friendly, and are less irritating to the human body, has been studied to some extent. However, the following problems have been found in the actual production of cosmetic compositions.

[0014] When the lipopeptide compound or its salt having the above-mentioned cyclic structure is used as an emulsifier, it is usually used in combination with a moisturizer containing a certain component, such as glycerin, as in, for example, Cited Document 3 (it is presumed that the moisturizer may be used as a solvent for the lipopeptide compound). However, when combined in this manner, it is thought that the desired effect of sufficiently promoting the skin permeability of physiologically active ingredients is not achieved in multi-component cosmetic compositions.

[0015] Furthermore, as described in Reference 2, referring to Figure 1 of the present invention (Figure 2 in Reference 2), emulsion systems containing various surfactants were prepared, and the emulsion system using a lipopeptide compound having a cyclic structure or its salt (Kaneka Surfactin) showed high emulsifying ability and emulsion stability. However, due to its high emulsifying ability, the emulsion system formed has a distinctly white and opaque appearance, which can be disadvantageous in imparting a refreshing and transparent appearance when preparing external skin cosmetics.

[0016] In view of the above-mentioned problems of the prior art when producing a cosmetic composition for external use on the skin using a lipopeptide compound having a cyclic structure or a salt thereof, the present invention primarily provides a cosmetic composition using a lipopeptide compound having a cyclic structure or a salt thereof. By combining a specific ingredient with the lipopeptide compound, this cosmetic composition can impart high transparency to the composition, even when an oil component is added to the composition to form a clear emulsion (particularly an oil-in-water emulsion), thereby giving the product a refreshing and transparent appearance and simultaneously improving the skin permeation-promoting effect of the lipopeptide compound on the physiologically active ingredient. [Means for solving the problem]

[0017] As a result of extensive research, the present inventors have found that the above-mentioned problems can be solved by implementing the following embodiment.

[0018] [1].First, the present invention is As components, a lipopeptide compound having a cyclic structure or a salt thereof (A), Glycerin (B), a long-chain fatty acid (C) having a branched structure; A cosmetic composition comprising isostearyl alcohol (D) and water, Based on the total weight of the composition, The cosmetic composition has a content of the component (A) of more than 0% by mass and not more than 4% by mass. [2] The composition according to [1], wherein the lipopeptide compound having a cyclic structure or a salt thereof (A) comprises a metal salt of surfactin. [3] The composition according to [1] or [2], wherein the long-chain fatty acid (C) having a branched structure is one or more selected from fatty acids having 14 to 24 carbon atoms and having a branched structure. [4] The content of the component (B) is more than 0% by mass and not more than 30% by mass, The content of the component (C) is more than 0% by mass and not more than 2% by mass, The composition according to any one of [1] to [3], wherein the content of the component (D) is more than 0 and 2% by mass or less. [5] The composition according to any one of [1] to [4], further comprising a diol compound (E). [6] The composition according to any one of [1] to [5], further comprising a physiologically active ingredient and / or an oil ingredient. [7]. A method comprising mixing a first ingredient part and a second ingredient part, The first raw material part contains water, the second raw material part contains the components (A), (C), and (D), The method for preparing a composition according to any one of [1] to [6], wherein the component (B) is present in the first raw material part and / or the second raw material part in an arbitrary proportion. [8]. The preparation method according to [7], wherein in the second raw material part, the mass of the component (C) is 0.20 to 0.80 times the mass of the component (A), and / or the amount of the component (D) used is 0.20 to 0.80 times the amount of the component (A). [9]. A composition according to any one of [1] to [6], or a composition obtained by the preparation method according to [7] or [8], having an L value of 90 or more.

[10] . The composition according to any one of [1] to [6], or the composition obtained by the preparation method according to [7] or [8], which is an emulsion system. [Effects of the Invention]

[0019] By implementing the above-described embodiment, the present invention can achieve the following effects. 1) The cosmetic composition according to the present invention has excellent transparency and can provide users with a refreshing, non-sticky appearance and feel when used, and can maintain a high level of transparency even when an oil component is added (forming a clear emulsion). 2) By using specific components such as a long-chain fatty acid (C) having a branched structure, isostearyl alcohol (D), and glycerol in combination, the cosmetic composition according to the present invention not only maintains the favorable surface activity and antibacterial properties of the lipopeptide compound or its salt (A) having a cyclic structure, but also makes it possible to obtain a composition with excellent transparency, and further improves the transdermal absorption-promoting effect of functional components, particularly physiologically active components, compared to conventional techniques. [Brief explanation of the drawings]

[0020] [Figure 1] A study of the emulsifying properties of various surfactants in the prior art [Figure 2] Comparison of appearance of conventional formulation and composition of the present invention [Figure 3] Simulation of Prior Art Embodiments DETAILED DESCRIPTION OF THE INVENTION

[0021] The present invention will be described in detail below. The technical features described below will be explained based on typical embodiments and specific examples of the present invention, but the present invention is not limited to these embodiments and specific examples.

[0022] In this specification, a numerical range expressed as "numerical value A to numerical value B" means a range including the limit values ​​A and B. As used herein, the term "basic" or "substantial" means that the standard deviation from the theoretical model or data is within 3%, preferably 2%, and more preferably 1%, and this deviation includes systematic deviation. In this specification, the term "may" means that the treatment may or may not be carried out. In this specification, "normal temperature" or "room temperature" means an indoor temperature of 23±2°C. In this specification, the terms "first raw material part" and "second raw material part" are simply names used to distinguish between them, and "first" and "second" do not represent any meaning or concept regarding order. As used herein, "optional" or "optional" means that the event or circumstance described below may or may not occur, and the description includes both cases where the event occurs and cases where it does not occur. As used herein, references to "some specific / preferred embodiments," "other specific / preferred embodiments," "embodiments," etc., mean that particular elements (e.g., features, structures, properties, and / or characteristics) described in connection with an embodiment are included in at least one embodiment described herein and may or may not be present in other embodiments. Furthermore, it is to be understood that such elements may be combined in any suitable manner in the various embodiments.

[0023] The present invention primarily provides a cosmetic composition for external use on skin prepared using a lipopeptide compound having a cyclic structure or its salt. By using specific components (a long-chain fatty acid having a branched structure (C) and isostearyl alcohol (D)) in combination with glycerin in the composition, it is possible to obtain a composition with excellent transparency that not only maintains the good surfactant activity and antibacterial properties of the lipopeptide compound having a cyclic structure or its salt (A), but also further improves the transdermal permeation and absorption-promoting effect of functional ingredients, particularly physiologically active ingredients, compared to conventional techniques.

[0024] <First aspect> A first aspect of the present invention provides a cosmetic composition for external application to the skin, comprising as essential ingredients (A) a lipopeptide compound having a cyclic structure or a salt thereof, (B) glycerin, (C) a long-chain fatty acid having a branched structure, (D) isostearyl alcohol, and water.

[0025] In the present invention, by using the above components (B) to (D), not only can the human skin permeability to the physiologically active substance that can be used with component (A) be improved, but also the transparency of the composition system can be maintained even when an additional oil component is used.

[0026] Component (A) Component (A) of the present invention is a biosurfactant having surface activity, specifically a lipopeptide-based surface active component having a cyclic structure.

[0027] The present invention is not particularly limited by the specific structure of the lipopeptide surfactants described above. For the specific structures of these substances or their salts, the substance represented by formula (1) disclosed in Japanese Patent No. 5906194 is cited as prior art.

[0028] Furthermore, examples of salts of the lipopeptide compound having the above-mentioned cyclic structure include various metal salts. In the present invention, a combination of one or more of alkali metal salts, alkaline earth metal salts, and ammonium salts is preferred, and alkali metal salts, particularly sodium salts, are more preferred.

[0029] In principle, component (A) of the present invention can be obtained by microbial fermentation. In some preferred embodiments of the present invention, it can be produced by fermentation of the microorganism Bacillus subtilis, thereby obtaining a lipopeptide surfactant component with extremely high water solubility and an anionic cyclic structure represented by the following structural formula (1). However, the length of the alkyl chain and the branching position are not limited to those of structural formula (1), and may include a structure in which one amino acid is replaced with another amino acid. [ka]

[0030] The structure of formula (1) is a cyclic peptide hydrophilic group consisting of seven amino acids bound to a β-hydroxy fatty acid. The unique cyclic peptide structure allows hydrogen bonds to form between molecules when forming micelles in water, allowing for the formation of aggregates with a very small number of molecules, resulting in stronger binding strength than other surfactants. Therefore, the critical micelle concentration (CMC) of the above structure is only 0.0003% (mass fraction), making it one of the surfactants with the lowest CMC, and it has been reported to exhibit very strong emulsifying properties.

[0031] The lipopeptide compound having the above cyclic structure or its salt can be obtained as a mixture of one or more types by the above biological fermentation method, and can also be purchased as a commercial product (KANEKA Surfactin).

[0032] Furthermore, with regard to the content of component (A) in the cosmetic composition of the present invention, in some specific embodiments, the amount of component (A) used, based on the total mass of the cosmetic composition, may be 4% by mass or less, preferably 3.5% by mass or less, and more preferably 3% by mass or less. Using too much component (A) can lead to an undesirable increase in production costs, as well as the risk of the cosmetic feeling being unpleasant to the touch and sticky after application to the skin. Furthermore, using too much component (A) can result in excessive foaming due to the strong emulsifying properties of component (A), which can affect the filling ability of the cosmetic and reduce the transparency of its appearance.

[0033] There is no particular lower limit to the amount of component (A) used, but it may usually be more than 0, and is preferably 0.0001% by mass or more, more preferably 0.001% by mass or more, even more preferably 0.01% by mass or more, and even more preferably 0.1% by mass or more, 0.2% by mass or more, etc.

[0034] Ingredient (B) Component (B) of the present invention is a glycerin component. Glycerin components are usually used as moisturizers or solvents. In the present invention, glycerin can be used to dissolve the lipopeptide compound having a cyclic structure or its salt (A) or can be used as a carrier thereof.

[0035] Therefore, component (B) may be added alone to the composition, or may be mixed with other components of the composition, or it may be mixed first with component (A) and then with other components to obtain the cosmetic composition of the present invention.

[0036] Regarding the amount of component (B) used in the present invention, in some specific embodiments, the amount of component (B) used, based on the total mass of the cosmetic composition, may be 30% by mass or less, preferably 25% by mass or less, and more preferably 20% by mass or less or 18% by mass or less. If the amount of component (B) used is too large, the cosmetic composition may feel unpleasant to the touch and may feel sticky after application to the skin.

[0037] There is no particular lower limit to the amount of component (B) used, but it may usually be more than 0 and is preferably 0.0003% by mass or more, more preferably 0.003% by mass or more, more preferably 0.01% by mass or more, still more preferably 0.10% by mass or more, 0.20% by mass or more, 1.00% by mass or more, 3.00% by mass or more, etc. If the amount used is too small, the transmittance may decrease, and the transparency of the system may decrease.

[0038] In some preferred embodiments of the present invention, at least a portion of component (B) can be used together with component (A) as a solvent or carrier (i.e., they are mixed as raw materials and then added to the composition at the same time). In this case, in a mixture containing components (A) and (B), the amount of component (B) used is 1.0 to 4.0 times, preferably 1.5 to 3.5 times, the mass of component (A). By using such an amount, the present invention is believed to be able to improve the dispersibility of component (A) in cosmetic ingredients, which can contribute to the effect of component (A) in promoting the skin permeability of available physiologically active ingredients.

[0039] Furthermore, in another specific embodiment of the present invention, component (B) may be used solely as a solvent or carrier for component (A), or a portion of component (B) may be used as a solvent or carrier for component (A), with the remainder being added directly or alone to the cosmetic composition.

[0040] Furthermore, the present invention has discovered that by blending the following components (C) and (D) with a cosmetic composition containing the above components (A) and (B), not only is it possible to improve the skin permeability of the physiologically active ingredient that can be used with component (A), but it is also possible to obtain a composition that has an appearance with excellent transparency that has not been previously obtainable.

[0041] Components (C) and (D) will be described below.

[0042] Ingredients (C) Component (C) of the present invention may be a long-chain fatty acid having a branched structure, and is preferably a saturated fatty acid.

[0043] The term "long chain" as used herein refers to an aliphatic chain having more than 12 carbon atoms. In some specific embodiments of the present invention, component (C) of the present invention may be a fatty acid having 14 to 24 carbon atoms and having a branched structure. In a preferred embodiment of the present invention, component (C) may be isostearic acid or isopalmitic acid, and more preferably isostearic acid.

[0044] Regarding the amount of component (C) used in the present invention, in some specific embodiments, the amount of component (C) used may be 2% by mass or less, preferably 1.8% by mass or less, 1.5% by mass or less, and more preferably 1.0% by mass or less, based on the total mass of the cosmetic composition. If the amount of component (C) used is too large, the permeability enhancement of the cosmetic composition will not be significantly improved, and the transparency of the cosmetic composition may be impaired.

[0045] There is no particular lower limit to the amount of component (C) used, but it may usually be more than 0, and is preferably 0.00002 mass% or more, more preferably 0.003 mass% or more, even more preferably 0.01 mass% or more, still more preferably 0.02 mass% or more, 0.05 mass% or more, 0.10 mass% or more, etc.

[0046] Furthermore, from the viewpoint of the effect of component (A) in promoting the skin permeability of physiologically active substances that can be used, in some preferred embodiments of the present invention, the amount of component (C) used may be 0.20 to 0.80 times, and more preferably 0.25 to 0.60 times, the amount of component (A) used.

[0047] Ingredients (D) Component (D) of the present invention may be isostearyl alcohol. Regarding the amount of component (D) used in some specific embodiments of the present invention, the amount of component (D) used may be 2% by mass or less, preferably 1.8% by mass or less, 1.5% by mass or less, and more preferably 1.0% by mass or less, based on the total mass of the cosmetic composition. If the amount of component (D) used is too large, the permeability enhancement of the cosmetic composition may not be significantly improved, and the transparency of the cosmetic composition may be impaired.

[0048] There is no particular lower limit to the amount of component (D) used, but it may usually be more than 0, and is preferably 0.00002 mass% or more, more preferably 0.003 mass% or more, even more preferably 0.01 mass% or more, still more preferably 0.02 mass% or more, 0.05 mass% or more, 0.10 mass% or more, etc.

[0049] Furthermore, in view of the effect of component (A) in promoting the skin permeability of physiologically active substances that can be used, in some preferred embodiments of the present invention, the amount of component (D) used may be 0.20 to 0.80 times, and more preferably 0.25 to 0.60 times, the amount of component (A) used.

[0050] In addition to the above essential components, the cosmetic composition according to the present invention may contain one or more of the various components shown below, if necessary.

[0051] Ingredient (E) Component (E) of the present invention is a diol compound. In principle, there are no particular restrictions on the diol compound that can be used in the present invention, but various diols that are commonly used in the cosmetic field can be used.

[0052] Component (E) can partially function as a moisturizer / solvent. Therefore, component (E) may be added alone to the composition, or may be mixed with other components of the composition. Alternatively, at least a portion of component (E) may be mixed with component (A) first, and then mixed with other components to obtain the cosmetic composition of the present invention. On the other hand, using a certain amount of component (E) can reduce the amount of component (B) used.

[0053] In some specific embodiments, component (E) of the present invention may be an alkylene glycol having a branched chain or branched structure and having 2 to 8 carbon atoms, preferably 3 to 6 carbon atoms. Specific examples include a mixture of one or more diols such as propylene glycol, butylene glycol, isoprene glycol, and 1,2-hexanediol.

[0054] In principle, the amount of component (E) used in the present invention is not particularly limited, but in some specific embodiments, the amount of component (E) used, based on the total mass of the cosmetic composition, may be 25 mass% or less, preferably 20 mass% or less, also preferably 18 mass% or less, further preferably 15 mass% or less, and even more preferably 10 mass% or less. If the amount of component (E) used is too large, the skin permeability of physiologically active substances that may be present in the cosmetic composition may be reduced, or the sustainability of the transparency of the resulting cosmetic composition may be impaired.

[0055] The lower limit of the amount of component (E) used is not particularly limited, but may usually be more than 0, and is preferably 0.00002 mass% or more, more preferably 0.003 mass% or more, even more preferably 0.01 mass% or more, still more preferably 0.10 mass% or more, 0.50 mass% or more, 1.00 mass% or more, 2.00 mass% or more, etc.

[0056] Physiologically active substances As described above, one of the functions of the cosmetic composition of the present invention is that, when the composition of the present invention has a specific composition and contains physiologically active substances, it can increase the permeability of lipopeptide compounds of these physiologically active substances into human skin.

[0057] In principle, there are no particular limitations on the physiologically active substances that can be used in the present invention, as long as they do not impair the transparency of the composition of the present invention.

[0058] Examples of physiologically active substances that can be used include one or more of antioxidant components, (bio)moisturizing components, anti-aging components, cell repair components, cell nutrition components, whitening-promoting components, antibacterial components, anti-allergic components, and vitamin components.

[0059] Further specific examples of these physiologically active substances include arbutin and its derivatives, L-ascorbic acid and its derivatives (e.g., ascorbyl phosphate, etc.), hydroquinone and its derivatives, glutathione and its derivatives, pantothenic acid and its derivatives, tranexamic acid and its derivatives, kojic acid and its derivatives, cysteine ​​and its derivatives, ellagic acid and its derivatives, resorcinol derivatives, plant extracts such as chamomile extract and licorice root extract, superoxide dismutase and its derivatives, mannitol and its derivatives, rutin and its derivatives, bilirubin and its derivatives, tryptophan and its derivatives, histidine and its derivatives, flavonoids such as quercetin and quercitrin, catechin and its derivatives, gallic acid and its derivatives, vitamin C and its derivatives (isoascorbic acid and its derivatives), sesamin and its derivatives, α-lipoic acid and its derivatives, glycyrrhizic acid and its derivatives (e.g., dipotassium glycyrrhizinate), , glycyrrhizic acid such as ammonium glycyrrhizinate), thiotaurine and its derivatives, urea and its derivatives, glycerin and its derivatives, xylitol and its derivatives, erythritol and its derivatives, salicylic acid and its derivatives (e.g., salicylate, 4-methoxysalicylic acid, etc.), nicotine and its derivatives, nicotinic acid and its derivatives (e.g., nicotinate, nicotinamide, etc.), hydroxyproline and its derivatives, serine and its derivatives, glutamic acid and its derivatives (e.g., glutamic acid, pyroglutamic acid, pyroglutamic acid, L-theanine, etc.), trimethylglycine and its derivatives, arginine and its derivatives, alanine and its derivatives, adenosine and its derivatives, lysine and its derivatives, lignans and their derivatives, minoxidil and its derivatives, finasteride and its derivatives, flavanones, tannic acid and its derivatives, ferulic acid and its derivatives, fullerene and its derivatives, 1-hydroxymethyl-5,Examples of such compounds include 5-dimethylhydantoin and its derivatives, D-amino acids and their derivatives, oligosaccharides and their derivatives, D-glucosamine and its derivatives (e.g., chitin, chitosan, etc.), sodium chondroitin sulfate and its derivatives, sorbitol and its derivatives, trehalose and its derivatives, hyaluronic acid and its derivatives, maltitol and its derivatives, raffinose and its derivatives, alginic acid and its derivatives, caffeine and its derivatives, keratin hydrolysate and its derivatives, silk protein hydrolysate and its derivatives, azelaic acid and its derivatives, γ-aminobutyric acid and its derivatives, allantoin and its derivatives, γ-oryzanol and its derivatives, L-carnitine and its derivatives, β-1,3-glucan and its derivatives, biotin and its derivatives, pyridoxine hydrochloride and its derivatives, and royal jelly such as propolis.

[0060] In principle, there are no particular limitations on the amount of the physiologically active substance used, as long as it does not impair the transparency of the cosmetic composition of the present invention. In some specific embodiments of the present invention, the amount of the physiologically active substance used may be 0.01% by mass to 1000% by mass, preferably 0.10% by mass to 500% by mass, and more preferably 0.20% by mass to 300% by mass, of the mass of component (A).

[0061] oil component The cosmetic composition of the present invention may contain a predetermined amount of an oil component so that the composition exists in the form of an emulsion. As described above, by incorporating the specific components of the present invention, the composition can have a transparent appearance even when it exists as an emulsion.

[0062] The oil component that can be used in the composition of the present invention is not particularly limited and can be selected from those commonly used in cosmetics as long as they have transparency. Preferred oil components include mixtures of one or more of hydrocarbon oils, silicone oils, ester oils, and other liquid oils and fats.

[0063] As the hydrocarbon oil, an alkane or (poly)olefin oil can be used, and examples thereof include liquid paraffin, squalane, squalene, paraffin, isoparaffin, ceresin, petrolatum, and hydrogenated polydecene.

[0064] Examples of silicone oils include chain silicones such as dimethylpolysiloxane, methylphenylpolysiloxane, and methylhydrogenpolysiloxane; cyclic silicones such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexasiloxane; and silicone resins and silicone rubbers that have a three-dimensional network structure.

[0065] Examples of liquid oils and fats include mono- or poly-fatty acid esters of glycerin, glycerin polycondensates, phytosterol esters, etc., which have a melting point of less than 50° C., particularly room temperature or lower. In the present invention, examples of such liquid oils and fats include palm oil, palm kernel oil, linseed oil, camellia seed oil, macadamia oil, corn oil, mink oil, olive oil, avocado oil, camellia oil, castor oil, safflower oil, jojoba oil, sunflower oil, almond oil, rapeseed oil, sesame oil, soybean oil, peanut oil, triglycerol, tricaprylin, triisopalmitin, glyceryl monostearate, glyceryl monoisostearate, glyceryl monooleate, glyceryl monohydroxystearate, and glyceryl monomyristate.

[0066] Examples of ester oils include cetyl octanoate, hexyl laurate, isopropyl myristate, octyl palmitate, isocetyl stearate, isopropyl isostearate, octyl isopalmitate, isodecyl oleate, glyceryl tri(2-ethylhexanoate), pentaerythritol tetra-2-ethylhexanoate, bis(2-ethylhexyl) succinate, and diethyl sebacate.

[0067] With regard to the oil component, from the viewpoint of maintaining the transparency of the final cosmetic, the content of the oil component may be 2.5% by mass or less, preferably 2.2% by mass or less, even more preferably 2.0% by mass or less, and even more preferably 0.00005% by mass to 1.8% by mass, for example, 0.001% by mass, 0.01% by mass, 0.1% by mass, 0.2% by mass, 0.5% by mass, 1.0% by mass, etc., based on the total mass of the cosmetic composition of the present invention.

[0068] Other ingredients In addition to the various components described above, the cosmetic composition of the present invention may contain other optional components as long as they do not affect the effects of the present invention.

[0069] These optional components include surfactants other than the above components, moisturizers, powders, alcohol-based solvents, water-soluble polymers, oil-soluble polymers, film-forming agents, UV absorbers, preservatives, antibacterial agents, fragrances, salts, antioxidants, pH adjusters, chelating agents, cooling agents, anti-inflammatory agents, skin-beautifying components, and the like.

[0070] The composition of the present invention, which is composed of the above-mentioned various components, can have excellent transparency even when it contains an oil component. In some specific embodiments, the cosmetic composition of the present invention may have an L value of 90 or more, preferably 95 or more, and more preferably 99 or more. Furthermore, the L value after storage at 50°C for 3 days may be greater than 80, preferably 85 or more. This demonstrates the excellent transparency and stability of transparency of the present invention. This is because, in conventional technology, even the L value (instantaneous) of a microemulsion is usually around 80 and does not exceed 90.

[0071] <Second aspect> In a second aspect of the present invention, a method for preparing the cosmetic composition of the present invention is described. The preparation method of the present invention may include a step of mixing at least the first raw material part and the second raw material part.

[0072] The first ingredient part comprises at least water, and in some specific embodiments, said first ingredient part may comprise at least a portion of component (B) and / or at least a portion of component (E).

[0073] The second raw material part may contain at least a part or all of the components (A), (C), (D), and (E). Component (B) may be present at least partially in the second raw material part, or may be distributed between the first and second raw material parts in any proportion.

[0074] The second raw material part may also contain at least a portion of water.

[0075] In some preferred embodiments of the present invention, when a physiologically active ingredient is present, the physiologically active ingredient may be present in the first ingredient part, the second ingredient part, or both the first and second ingredient parts. From the viewpoint of operational convenience and compatibility, the physiologically active ingredient is preferably present in the first ingredient part.

[0076] In some preferred embodiments of the present invention, when an oil component is present, the oil component may be present in the first raw material part, the second raw material part, or both the first and second raw material parts. Alternatively, from the viewpoint of forming a highly stable emulsion system, at least a portion of the oil component may be mixed with the first raw material part and the second raw material part after they are mixed.

[0077] Therefore, in a further preferred embodiment of the present invention, i) the first raw material part contains water, a portion of component (B), and a portion of component (E); ii) The second raw material part comprises components (A), (C), (D), the remaining component (B), and the remaining component (E), and the amount of component (B) used in the second raw material part is 1.0 to 4.0 times, and preferably 1.5 to 3.5 times, the mass of component (A), and the content of component (E) based on the total mass of the composition is 2.2 mass% or less, for example, 2.0 mass% or less, 1.8 mass% or less, and 0.00001 mass% or more, 0.001 mass% or more, 0.01 mass% or more, or 0.1 mass% or more.

[0078] In another preferred embodiment of the present invention, i) the first raw material part contains water and a part of component (B), ii) The second raw material part contains components (A), (C), (D), a portion of component (B), and component (E), the amount of component (B) used in the second raw material part is 1.0 to 4.0 times, and preferably 1.5 to 3.5 times, the mass of component (A), and the content of component (E) based on the total mass of the composition is 2.2 mass% or less, for example, 2.0 mass% or less, 1.8 mass% or less, and 0.00001 mass% or more, 0.001 mass% or more, 0.01 mass% or more, or 0.1 mass% or more.

[0079] When preparing the composition of the present invention, in addition to the above-mentioned raw material parts, other raw material parts may optionally be present, for example, at least a part of the above-mentioned oil component may be used alone as another raw material part. In addition, other raw material parts that can be used independently may contain other optional components of the present invention.

[0080] In some specific embodiments, the cosmetic composition of the present invention may be prepared by the above-mentioned preparation method in the form of an emulsion (microemulsion), particularly an oil-in-water emulsion. The emulsion preferably has an average particle size of emulsion droplets of 10 to 100 nm, and may be 20, 30, 40, 50, 60, 70, 80, 90 nm, etc.

[0081] From the standpoints of production and use, the cosmetic composition obtained by the present invention maintains a good feeling in use without causing a sticky feeling and provides consumers with a refreshing feel on the skin, so that it has a viscosity of 20,000 mPa·s, 15,000 mPa·s, 10,000 mPa·s, 8,000 mPa·s, 6,000 mPa·s, 5,000 mPa·s, 4,000 mPa·s, or 3,000 mPa·s or less (room temperature), and 1 mPa·s, 10 mPa·s, 20 mPa·s, or 30 mPa·s or more (room temperature). More preferably, the viscosity is 4,000 to 9,000 mPa·s (room temperature). [Example]

[0082] The present invention will now be further described with reference to specific examples.

[0083] How to measure the L value The sample was filled into a quartz glass dish (optical path length: 10 mm) without dilution, and the transmittance was measured at 20°C using an integrating sphere spectrophotometer (X. Rite). That is, the sample was uniformly irradiated with light from various angles using an integrating sphere, and the ratio (%) of the intensity of the transmitted light to the intensity of the irradiated light received in the normal direction of the sample surface was calculated as the L value.

[0084] Transmission measurement method (Franz cell measurement method) : Carnosine measurement method: A permeable membrane (Start M, Merck) was attached to a Franz cell. The receiving side of the membrane was filled with PBS buffer, and the supply side was filled with 0.78 ml of sample. The permeable membrane was set at a diameter of 1 cm and 39°C. After 24 hours of permeation, the carnosine content in the receiving side of the PBS buffer was measured by HPLC.

[0085] Sodium hyaluronate measurement method: A permeable membrane (Start M, Merck) was attached to a Franz cell, and the receiving side of the permeable membrane was filled with PBS buffer, while the supply side was filled with 7.8 μL of sample. The permeable membrane was permeated under conditions of 1 cm diameter and 39°C. After 24 hours of permeation, the sodium hyaluronate content in the permeable membrane was measured according to the method specified in the ELISA kit (hyaluronan qkit, DHYALO).

[0086] Each of the following Examples, Comparative Examples and Reference Examples was obtained by mixing as follows. After mixing the second raw material part according to the composition shown in the table, the second raw material part was mixed with the first raw material part, and finally mixed with the third raw material part to obtain the final cosmetic composition. The values ​​for each component are percentage contents.

[0087] Reference example: Reference Examples 1 to 3 were obtained according to the following formulations.

[0088] [Table 1]

[0089] The above Reference Examples demonstrate that the effects of the present invention can be achieved even when small amounts of the components (A) to (E) of the present invention are used. Furthermore, it is possible to use glycerin in higher amounts.

[0090] Example Examples 1 to 5 were obtained according to the following formulations.

[0091] [Table 2]

[0092] From the above examples and comparative examples, it is clear that by using a diol (i.e., component (E)) in the composition of the present invention, a cosmetic composition with excellent transparency and permeability can be obtained.

[0093] Examples 6 to 10 and Comparative Examples 1 to 4 were obtained according to the following formulations.

[0094] [Table 3]

[0095] The above examples and comparative examples demonstrate that by using isostearic acid (i.e., component (C)) and isostearyl alcohol (i.e., component (D)) in the composition of the present invention, a cosmetic composition with excellent transparency and permeability can be obtained.

[0096] Example 1 and Examples 11 to 14 were obtained according to the following formulation.

[0097] [Table 4]

[0098] The above examples demonstrate that the cosmetic composition of the present invention can have good transparency and permeability even when it forms an emulsion system (oil-in-water type) in the presence of an oil component.

[0099] Examples 15 and 16 and Reference Example 4 were obtained according to the following formulations.

[0100] [Table 5]

[0101] Examples 15 and 16 above show that excessive amounts of components (C) and (D) can affect transparency retention and permeability, and Reference Example 4 shows that excessive amounts of oil components can deteriorate transparency when an emulsion is formed.

[0102] Examples 17 and 18 and Comparative Example 5 were obtained according to the following formulations.

[0103] [Table 6]

[0104] Comparison of the above Examples and Comparative Examples reveals that if the amount of surfactin used is too large, it may affect the usability and transparency of the cosmetic composition.

[0105] Examples 19 and 20 and Comparative Examples 6 and 7 were obtained according to the following formulations.

[0106] [Table 7]

[0107] It can be seen that the permeability of the active ingredient in Example 18 was 3.3 times that of Comparative Example 6. The permeability of the active ingredient in Example 20 was 11 times that of Comparative Example 7.

[0108] Comparison of cosmetic formulation forms: Cosmetics were obtained according to the formulation shown in the table below.

[0109] [Table 8]

[0110] [Table 9]

[0111] Furthermore, FIG. 2 shows the appearance of the cosmetic compositions of Formulation 1, Formulation 2 and the present invention, and demonstrates that the present invention can achieve a transparent appearance.

[0112] Comparison of conventional cosmetic formulations: Table 10 below is a simulation of Example 10 of JP2003277220A (only some non-essential additive components have been removed).

[0113] [Table 10]

[0114] After preparation by the preparation method described in the same document, phase separation occurred after 2 hours, the emulsion system became unstable, and the transparent appearance of the present invention was not obtained (FIG. 3).

[0115] Although the technical solutions of the present invention have been described with specific examples, those skilled in the art will understand that the present disclosure is not limited thereto. Although the embodiments of the present disclosure have been described above, the above description is merely illustrative and not exhaustive, and is not limited to the disclosed embodiments. Various modifications and alterations will be apparent to those skilled in the art without departing from the scope and spirit of the described embodiments. The terminology used in this specification is intended to best interpret the principles, practical applications, or improvements to commercially available technologies of the embodiments, or to allow other skilled artisans to understand the embodiments disclosed herein. [Industrial Applicability]

[0116] The cosmetic composition provided by the present invention can be produced industrially.

Claims

1. As components, a lipopeptide compound having a cyclic structure or a salt thereof (A), Glycerin (B), a long-chain fatty acid (C) having a branched structure; A cosmetic composition comprising isostearyl alcohol (D) and water, Based on the total weight of the composition, A cosmetic composition characterized in that the content of the component (A) is more than 0% by mass and 4% by mass or less.

2. 2. The composition according to claim 1, wherein the lipopeptide compound having a cyclic structure or a salt thereof (A) comprises a metal salt of surfactin.

3. 3. The composition according to claim 1, wherein the long-chain fatty acid (C) having a branched structure is one or more selected from fatty acids having 14 to 24 carbon atoms and having a branched structure.

4. The content of the component (B) is more than 0 and 30% by mass or less, The content of the component (C) is more than 0% by mass and not more than 2% by mass, The composition according to any one of claims 1 to 3, characterized in that the content of the component (D) is more than 0% by mass and 2% by mass or less.

5. The composition according to any one of claims 1 to 4, further comprising a diol compound (E).

6. The composition according to any one of claims 1 to 5, further comprising a physiologically active ingredient and / or an oil component.

7. 1. A method comprising mixing a first feed part and a second feed part, The first raw material part contains water, the second raw material part contains the components (A), (C), and (D), The method for preparing a composition according to any one of claims 1 to 6, wherein component (B) is present in the first raw material part and / or the second raw material part in an arbitrary proportion.

8. The method according to claim 7, characterized in that, in the second raw material part, the mass of the component (C) may be 0.20 to 0.80 times the mass of the component (A), and / or the amount of the component (D) used may be 0.20 to 0.80 times the amount of the component (A).

9. A composition according to any one of claims 1 to 6, or a composition obtained by the preparation method according to claim 7 or 8, having an L value of 90 or more.

10. A composition according to any one of claims 1 to 6, or a composition obtained by the preparation method according to claim 7 or 8, which is an emulsion system.

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