Oral composition

Abstract

To provide a composition for the oral cavity, excellent in effect feeling by use, and reduced in disagreeable taste.SOLUTION: This composition for the oral cavity comprises (A) sodium fluoride, (B) a water-soluble calcium salt, (C) one or more kinds selected from the group consisting of condensed phosphoric acids and their alkali metal salts, and (D) either one or both of sodium carbonate and sodium hydrogencarbonate.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to an oral composition. [Background technology]

[0002] A method is known in which sodium bicarbonate and other salts are added to oral compositions such as dentifrices to remove stickiness in the oral cavity and provide a refreshing feeling. However, sodium bicarbonate and other salts have a refreshing feeling but also have an astringent taste, a particular unpleasant taste, irritation, etc., which are problems, and methods for suppressing these problems have been proposed (for example, Patent Document 1). [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Japanese Patent Publication No. 2022-104233 Summary of the Invention [Problem to be solved by the invention]

[0004] The refreshing feeling experienced when using an oral composition is expected to enhance the user's sense of effectiveness and lead to increased willingness to use it. However, conventional methods have not necessarily been able to sufficiently suppress the unpleasant taste that is characteristic of carbonates. The present invention aims to provide an oral composition that provides excellent effects upon use and has a reduced unpleasant taste. [Means for solving the problem]

[0005] The present invention has the following aspects. [1] An oral composition containing (A) sodium fluoride, (B) a water-soluble calcium salt, (C) one or more members selected from the group consisting of condensed phosphoric acid and its alkali metal salts, and (D) either one or both of sodium carbonate and sodium bicarbonate. [2] The oral composition according to [1], wherein the component (B) comprises one or more selected from the group consisting of calcium chloride, calcium glycerophosphate, calcium gluconate, calcium lactate, and calcium pantothenate. [3] The oral composition according to [1] or [2], wherein the component (C) comprises one or more selected from the group consisting of pyrophosphoric acid and alkali metal pyrophosphates. [4] The oral composition according to any one of [1] to [3], which has a pH of 8 to 11 at 25°C. [5] The oral composition according to any one of [1] to [4], which is a dentifrice. [Effects of the Invention]

[0006] According to the present invention, an oral composition can be obtained which has an excellent feeling of effectiveness when used and has a reduced unpleasant taste. DETAILED DESCRIPTION OF THE INVENTION

[0007] As used herein, "oral composition" means a composition intended primarily for use in the oral cavity. In this specification, "water-soluble" means that the solubility in water at 20°C is 1 g / 100 g or more. In this specification, the use of "to" to indicate a range of values ​​means that the values ​​before and after it are included as the lower and upper limits.

[0008] [Oral composition] The oral composition of the present invention contains component (A), component (B), component (C), and component (D).

[0009] <Component (A)> Component (A) is sodium fluoride (NaF). Component (A) contributes to reducing the unpleasant taste caused by component (D). Component (A) can be a commercially available product.

[0010] <(B) component> Component (B) is a water-soluble calcium salt. Component (B) contributes to reducing the unpleasant taste caused by component (D).

[0011] Examples of component (B) include calcium chloride, calcium nitrate, calcium acetate, calcium citrate, calcium glycerophosphate, calcium gluconate, calcium benzoate, calcium formate, calcium fumarate, calcium lactate, calcium butyrate, calcium isobutyrate, calcium malate, calcium maleate, calcium propionate, calcium valerate, and calcium pantothenate. The component (B) may be a single compound or a combination of two or more compounds. Component (B) may be a commercially available product.

[0012] The component (B) preferably includes a component (B1) which is one or more members selected from the group consisting of calcium chloride, calcium glycerophosphate, calcium gluconate, calcium lactate, and calcium pantothenate. The proportion of the (B1) component relative to the total mass of the (B) component may be, for example, 90 mass% or more, 95 mass% or more, 96 mass% or more, 97 mass% or more, 98 mass% or more, or 99 mass% or more, or may be 100 mass%.

[0013] <(C) component> Component (C) is at least one selected from the group consisting of condensed phosphoric acid and alkali metal salts thereof. Component (C) may be a combination of two or more types. Component (C) contributes to reducing the unpleasant taste caused by component (D).

[0014] As the condensed phosphoric acid or its alkali metal salt, a water-soluble condensed phosphoric acid or its salt can be preferably used. Examples of condensed phosphoric acid include linear polyphosphoric acids such as pyrophosphoric acid, tripolyphosphoric acid, and tetrapolyphosphoric acid; and cyclic polyphosphoric acids such as trimetaphosphoric acid, tetrametaphosphoric acid, and hexametaphosphoric acid. Examples of the alkali metal salt of condensed phosphoric acid include sodium salt and potassium salt. In particular, from the viewpoint of reducing the unpleasant taste caused by component (D), pyrophosphate, tripolyphosphate, and hexametaphosphate are preferred, and pyrophosphate is more preferred. Specifically, potassium pyrophosphate and sodium pyrophosphate are particularly preferred. Component (C) can be a commercially available product.

[0015] Component (C) preferably contains component (C1), which is at least one selected from the group consisting of pyrophosphoric acid and alkali metal pyrophosphates. Component (C1) is particularly effective in reducing unpleasant tastes. The proportion of the (C1) component relative to the total mass of the (C) component may be, for example, 90 mass% or more, 95 mass% or more, 96 mass% or more, 97 mass% or more, 98 mass% or more, or 99 mass% or more, or may be 100 mass%.

[0016] <(D) component> Component (D) is either sodium carbonate or sodium bicarbonate, or both. Component (D) contributes to a refreshing feeling in the oral cavity and contributes to an improved feeling of effectiveness. Component (D) can be a commercially available product.

[0017] <Content of each ingredient> The content of component (A) is preferably 0.09 to 1.3% by mass, more preferably 0.10 to 1.1% by mass, based on the total mass of the oral composition. When the content of component (A) is equal to or greater than the lower limit, the effect of component (D) in reducing unpleasant taste is more excellent. When the content of component (A) is equal to or less than the upper limit, the flavor is more excellent.

[0018] The content of component (B) is preferably 0.02 to 5.0% by mass, more preferably 0.03 to 3.0% by mass, based on the total mass of the oral composition. When the content of component (B) is equal to or greater than the lower limit, the effect of reducing the unpleasant taste caused by component (D) is more excellent. When the content of component (B) is equal to or less than the upper limit, the flavor is more excellent.

[0019] The content of component (C) is preferably 0.02 to 3.0% by mass, more preferably 0.03 to 1.3% by mass, based on the total mass of the oral composition. When the content of component (C) is equal to or greater than the lower limit, the effect of reducing the unpleasant taste caused by component (D) is more excellent. When the content of component (C) is equal to or less than the upper limit, the flavor is more excellent.

[0020] The content of component (D) is preferably 0.1 to 60% by mass, more preferably 5 to 40% by mass, based on the total mass of the oral composition. When the content of component (D) is equal to or greater than the lower limit, the oral cavity is more effectively refreshed and the effect is more readily felt. When the content of component (D) is equal to or less than the upper limit, the unpleasant taste is less likely to linger after use and the flavor is more excellent.

[0021] The mass ratio of the total content of components (A), (B), and (C) to the content of component (D) (hereinafter also referred to as "(D) / {(A)+(B)+(C)}") is preferably 0.1 to 60, more preferably 4 to 50. When the mass ratio is equal to or greater than the lower limit of the above range, the effect of imparting a refreshing feeling to the oral cavity is superior, and the effect can be more clearly felt. When the mass ratio is equal to or less than the upper limit, the effect of reducing the unpleasant taste caused by component (D) is superior.

[0022] The molar ratio of component (B) to component (A) (hereinafter also referred to as "(B) / (A)") is preferably 0.03 to 10.0, more preferably 0.08 to 2.0. When (B) / (A) is within the above range, the unpleasant taste reduction effect of component (D) is more excellent.

[0023] The molar ratio of component (C) to component (A) (hereinafter also referred to as "(C) / (A)") is preferably 0.005 to 1.5, more preferably 0.01 to 1.3. When (C) / (A) is within the above range, the unpleasant taste reduction effect of component (D) is more excellent.

[0024] <Water> The oral composition typically further contains water, such as purified water, sterilized purified water, and water for injection. The content of water in the oral composition can be appropriately set depending on the product form and method of use of the oral composition. For example, when the oral composition is a toothpaste, the content of water relative to the total mass of the oral composition is preferably 5 to 90 mass%, more preferably 10 to 60 mass%, and even more preferably 20 to 50 mass%.

[0025] <Other ingredients> The oral composition may further contain other components in addition to the components (A), (B), (C), (D) and water. The other components can be appropriately selected from known components taking into consideration the form and method of use of the oral composition, etc. Examples of the other components include surfactants, abrasives, binders, thickeners, colorants, sweeteners, preservatives, flavorings, active ingredients, and pH adjusters.

[0026] As the surfactant, any surfactant known in oral compositions can be used, such as a nonionic surfactant, an amphoteric surfactant, an anionic surfactant, etc. Examples of nonionic surfactants include polyoxyethylene alkyl ethers, polyoxyethylene hydrogenated castor oil, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters (e.g., polyoxyethylene sorbitan monostearate), alkylolamides, polyoxyethylene fatty acid esters, polyoxyethylene alkenyl ethers, glycerin fatty acid esters, sucrose fatty acid esters (e.g., maltose fatty acid esters), sugar alcohol fatty acid esters (e.g., maltitol fatty acid esters, lactitol fatty acid esters), fatty acid diethanolamides (e.g., lauric acid mono- or diethanolamide), polyoxyethylene polyoxypropylene copolymers, polyoxyethylene polyoxypropylene fatty acid esters, polyoxyethylene polyoxypropylene (EOPO) copolymers, alkyl glucosides, and fatty acid polyglyceryl. The alkyl group of the polyoxyethylene alkyl ether usually has 12 to 18 carbon atoms, preferably 14 to 18 (for example, lauryl or stearyl group), and the average number of moles of ethylene oxide added is usually 5 to 30 moles, preferably 15 to 30 moles. The average number of moles of ethylene oxide added in polyoxyethylene hydrogenated castor oil is usually 5 to 100 moles, preferably 20 to 100 moles, and more preferably 20 to 60 moles. The number of carbon atoms in the fatty acid of the sorbitan fatty acid ester is usually 12 to 18. The number of carbon atoms in the fatty acid of the polyoxyethylene sorbitan fatty acid ester is usually 16 to 18, and the average number of moles of ethylene oxide added is usually 10 to 40 moles. The alkyl chain of the alkylolamide usually has 12 to 14 carbon atoms. The polyoxyethylene polyoxypropylene (EOPO) copolymer preferably has an average number of moles of ethylene oxide added of 20 to 210 and an average number of moles of propylene oxide added of 15 to 60, and may be a block copolymer or a random copolymer.

[0027] Examples of amphoteric surfactants include betaine-type amphoteric surfactants and amino acid-type amphoteric surfactants. Examples of betaine-type amphoteric surfactants include fatty acid amidopropyl betaines (e.g., coconut oil fatty acid amidopropyl betaine), alkyl acetate betaines (e.g., alkylamino acetate betaines such as lauryl dimethylamino acetate betaine), and alkyl imidazolinium betaines (e.g., alkylcarboxymethyl hydroxyethyl imidazolinium betaine). Among these, fatty acid amidopropyl betaines and alkyl acetate betaines are preferred, and coconut oil fatty acid amidopropyl betaine is more preferred. When the amphoteric surfactant has an alkyl group or an acyl group, they may be either linear or branched, and may be either saturated or unsaturated. The number of carbon atoms in the alkyl group or acyl group is preferably 10 to 20, more preferably 12 to 18, and even more preferably 14 to 16.

[0028] Examples of anionic surfactants include alkyl sulfates (e.g., sodium dodecyl sulfate (SDS)), α-olefin sulfonates (AOS), lauroyl methyl taurine (LMT), sulfosuccinic acid, GluNa, and alaninate. The alkyl group and acyl group may be either linear or branched, and may be either saturated or unsaturated. The number of carbon atoms in the alkyl group or acyl group is, for example, preferably 10 to 20, more preferably 12 to 18, and even more preferably 14 to 16. The salt may be selected from pharmacologically acceptable salts. Examples of pharmacologically acceptable salts include base addition salts and amino acid salts. Examples of salts include inorganic base salts such as sodium salt, potassium salt, calcium salt, magnesium salt, and ammonium salt; organic base salts such as triethylammonium salt, triethanolammonium salt, pyridinium salt, and diisopropylammonium salt; and basic amino acid salts such as arginine salt. Among these, inorganic base salts are preferred, alkali metal salts (e.g., sodium salt, potassium salt) or ammonium salts are more preferred, and sodium salts are even more preferred.

[0029] When the oral composition contains a surfactant, the content of the surfactant is preferably 0.05 to 10.0% by mass, more preferably 0.1 to 8.0% by mass, relative to the total mass of the oral composition.

[0030] Examples of abrasives include silica-based abrasives such as silicic acid anhydride, precipitated silica, silica gel, aluminosilicate, and zirconosilicate; dibasic calcium phosphate dihydrate or anhydrate, monobasic calcium phosphate, tribasic calcium phosphate, tetrabasic calcium phosphate, calcium carbonate, calcium hydroxide, aluminum hydroxide, insoluble sodium metaphosphate, tribasic magnesium phosphate, and magnesium carbonate. Silica-based abrasives are particularly preferred. The content of the abrasive is, for example, preferably 0 to 60% by mass, more preferably 0 to 30% by mass, and may be 25% by mass or less, relative to the total mass of the oral composition. An abrasive content of 0% by mass means that no abrasive is contained.

[0031] Examples of binders include organic binders selected from water-soluble polymeric substances such as cellulose derivatives such as sodium carboxymethylcellulose, methylcellulose, hydroxymethylcellulose, and hydroxyethylcellulose; gums such as xanthan gum, tragacanth gum, karaya gum, and gum arabic; and polyacrylates such as sodium polyacrylate; and inorganic binders such as thickening silica, thickening aluminum silica, Veegum, and Laponite. The content of the binder is preferably, for example, 0.05 to 13.0% by mass relative to the total mass of the oral composition. When the binder contains an organic binder, the blending amount of the organic binder is more preferably 0.1 to 3 mass %, and even more preferably 0.5 to 2.5 mass %, relative to the total mass of the oral composition. When the binder contains an inorganic binder, the content of the inorganic binder is more preferably 0 to 10.0 mass %, and even more preferably 0 to 8.0 mass %, relative to the total mass of the oral composition, in terms of the adsorption of fluoride ions to the tooth surface.

[0032] Examples of thickening agents include sugar alcohols such as sorbitol, xylitol, erythritol, and maltitol, and polyhydric alcohols such as glycerin, propylene glycol, and polyethylene glycol having an average molecular weight of 160 to 400 (average molecular weight according to the Quasi-drug Raw Materials Standards 2006). When the oral composition contains a binder, the content of the thickener is, for example, preferably 15% by mass or more, more preferably 20% by mass or more, relative to the total mass of the oral composition. The upper limit of the content of the thickener is, for example, preferably 70% by mass or less, more preferably 65% ​​by mass or less.

[0033] Examples of colorants include Red No. 2, Red No. 3, Red No. 225, Red No. 226, Yellow No. 4, Yellow No. 5, Yellow No. 205, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 204, Green No. 3, titanium mica, and titanium oxide. Examples of sweeteners include saccharin sodium, aspartame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidin dihydrochalcone, and perillartine. Examples of preservatives include parahydroxybenzoic acid esters such as methylparaben, ethylparaben, and butylparaben, and benzoic acid or a salt thereof such as sodium benzoate.

[0034] Examples of fragrances include peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, lime oil, lavender oil, rosemary oil, laurel oil, chamomile oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, and grapefruit oil. Natural fragrances such as citrus oil, sweetie oil, yuzu oil, iris concrete, peppermint absolute, rose absolute, orange flower, and processed fragrances (front distillation, tail distillation, liquid-liquid extraction, essence, powder fragrance, etc.) of these natural fragrances, menthol, carvone, anethole, cineole, methyl salicylate, cinnamic aldehyde, eugenol, 3-l-menthoxypropane-1,2-diol, thymol, linalool, linalyl aqua Examples of flavoring materials that can be used include single flavors such as acetate, limonene, menthone, menthyl acetate, N-substituted-paramenthan-3-carboxamide, pinene, octyl aldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate, ethyl methylphenyl glycidate, vanillin, undecalactone, hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cyclotene, furfural, trimethylpyrazine, ethyl lactate, and ethyl thioacetate, and compound flavors such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, and tropical fruit flavor. These flavoring materials can also be used in combination with other flavoring materials known for oral compositions. The content of the flavoring material is not particularly limited, but the content of the above-mentioned flavoring material is preferably 0.000001 to 1% by mass relative to the total mass of the oral composition. The content of the flavoring material used for flavoring is preferably 0.05 to 2% by mass relative to the total mass of the oral composition.

[0035] Examples of active ingredients include disinfectants such as isopropylmethylphenol and cetylpyridinium chloride, water-soluble phosphate compounds such as potassium and sodium orthophosphate (excluding component (C)), enzymes such as dextranase, mutanase, amylase, and protease, tranexamic acid, epsilon aminocaproic acid, triclosan, lysozyme chloride, aluminum chlorohydroxyallantoin, hinokitiol, ascorbic acid, tocopherol acetate, dihydrocholesterol, α-bisabolol, chlorhexidine salts, azulene, water-soluble copper compounds such as copper chlorophyllin sodium, chlorophyll, and copper gluconate, aluminum lactate, strontium chloride, potassium nitrate, berberine, hydroxamic acid or a derivative thereof, glycyrrhizic acid or a salt thereof, glycyrrhetinic acid or a derivative thereof, and anti-tartar agents. The above active ingredients can be incorporated in effective amounts within a range that does not interfere with the effects of the present invention.

[0036] Examples of pH adjusters include citric acid, tartaric acid, malic acid, and salts thereof such as potassium salts and sodium salts, and sodium hydroxide.

[0037] The pH of the oral composition at 25°C is preferably 8 to 11, more preferably 8.5 to 10. The pH of the oral composition in this specification is a value measured at 25°C after 3 minutes using a pH meter (model number InLab Routine Pro-ISM) manufactured by METTLER TOLEDO.

[0038] <Form, dosage form> The oral composition can be prepared in various forms, for example, liquid, paste, gel, or solid. The dosage form of the oral composition is not particularly limited. The dosage form of the oral composition is typically an oral preparation that is expelled from the oral cavity after use. Examples of oral preparations include dentifrices (liquid dentifrices, liquid dentifrices, toothpastes, lubricating dentifrices, powder dentifrices, etc.), mouthwashes, mouthwashes, liniments, mouth sprays, patches, sheets, oral sustained-release agents, chewable agents, oral dissolving agents, oral disintegrating agents, tongue care agents, mouth fresheners, denture care agents, etc. Among the above, the oral composition of the present embodiment is suitable as a dentifrice, and is particularly suitable as a toothpaste.

[0039] The oral composition of this embodiment can be prepared by a known method, for example, by mixing components (A), (B), (C), and (D), and optionally other components, by a conventional method.

[0040] In the oral composition, fluoride ions, calcium ions, and phosphorus ions form a complex, and it is believed that this complex contributes to reducing the unpleasant taste caused by component (D). The formation of the complex can be confirmed by observing the crystallite size by X-ray crystal structure analysis and the exothermic peak observed when water of crystallization near the phosphate group is released at around 450 °C by calorimetry (TG-DTA measurement). In other words, when the complex is formed, the crystallite size determined from the diffraction peaks attributable to CaF2 becomes less than 10 nm due to the complexation with the phosphate group. Furthermore, the appearance of a peak for water of crystallization indicates that the CaF2 observed in X-ray crystal structure analysis is not a crystal composed only of calcium and fluoride ions, but forms a complex in which the phosphate group interacts. Specifically, the formation of a complex is confirmed by the fact that the crystallite size is less than 10 nm as determined by the following method (1) and the presence of an exothermic peak at 450° C. as determined by the following method (2). (1) Crystallite size The sample was measured using an X-ray structural diffractometer (light source Cu:Kα, 40 kV, 20 mA, divergence slit 1 / 2 deg, scattering slit 1 / 2 deg, receiving slit 0.15 mm, scan speed 4,000° / min, 2θ = 2,000 to 80,000°), and the crystallite diameter was calculated using the following formula (Scherrer's formula) to evaluate whether or not a complex was formed. L=Kλ / (βcosθ) L: crystallite diameter, K: coefficient 0.9, β: half-width, λ: 1.54056 Å, θ: diffraction angle (2) TG-DTA measurement (exothermic peak) Heating speed: 5℃ / min, Measurement range: 25℃~600℃

[0041] The method for forming the above-mentioned complex is not particularly limited, but when preparing the oral composition, it is preferable to adopt, for example, a process of blending component (A) and component (C) and then blending component (B), or a process of blending component (B) and component (C) and then blending component (A). Note that if component (A) and component (B) are blended simultaneously, calcium fluoride may be partially produced, which may result in a lower efficiency of complex formation.

[0042] The oral composition described above contains components (A), (B), (C), and (D), and therefore provides a refreshing feeling when used, making the effect highly noticeable, and while it contains component (D), it has a suppressed unpleasant taste and a good flavor. [Example]

[0043] The present invention will be described in detail below with reference to examples, but the present invention is not limited to the following description. In the following examples, the unit of content "%" refers to "% by mass" unless otherwise specified.

[0044] <Raw materials used> [Component (A)] Sodium fluoride: manufactured by Stella Chemifa Co., Ltd. Also referred to as "NaF" hereinafter.

[0045] [(B) Component] Calcium glycerophosphate: manufactured by Iwaki Pharmaceutical Co., Ltd. Hereinafter also referred to as "calcium glycerophosphate." Calcium chloride: manufactured by Tomita Pharmaceutical Co., Ltd. Hereinafter also referred to as "Ca chloride." Calcium lactate hydrate: trade name "Calcium lactate" manufactured by Taihei Chemical Industry Co., Ltd. Also referred to as "Ca lactate" hereinafter. Calcium gluconate: manufactured by Fuso Chemical Co., Ltd. Hereinafter also referred to as "Calcium gluconate." Calcium pantothenate: manufactured by BASF. Hereinafter also referred to as "Ca pantothenate."

[0046] [(C) component] Tetrapotassium pyrophosphate: manufactured by Taihei Chemical Industry Co., Ltd. Hereinafter also referred to as "K pyrophosphate." Sodium pyrophosphate: Taihei Chemical Industry Co., Ltd., product name "Sodium pyrophosphate (anhydrous)". Hereinafter, also referred to as "Na pyrophosphate". Sodium tripolyphosphate: manufactured by Taihei Chemical Industry Co., Ltd. Hereinafter also referred to as "sodium tripolyphosphate."

[0047] [(D) component] Sodium bicarbonate: manufactured by Asahi Glass Co., Ltd. Hereinafter also referred to as "Na bicarbonate." Sodium carbonate: manufactured by Tokuyama Corporation. Hereinafter also referred to as "Na carbonate."

[0048] [Fragrance] Fragrance composition A as described in Table 4 below. [water] Purified water. [Common component (arbitrary component)] Polyoxyethylene hydrogenated castor oil 0.5%, silicic anhydride (abrasive silica) 10%, sodium carboxymethylcellulose 1%, propylene glycol (thickener) 20%, and xanthan gum (binder) 0.5%. Total 32%.

[0049] <Examples 1 to 20 and Comparative Examples 1 to 4> Oral compositions (toothpastes) having the compositions shown in Tables 1 to 3 were prepared by a conventional method. The components were mixed in the order of the aqueous solution of component (C), the aqueous solution of component (B), and the aqueous solution of component (A) to prepare a preliminary mixture. The amount of water was the amount required to achieve the composition shown in the table. An A phase was prepared by adding and dissolving a water-soluble component (sodium carboxymethyl cellulose) to this preliminary mixture. On the other hand, a B phase was prepared by dissolving and dispersing xanthan gum in propylene glycol at room temperature. Next, the B phase was added to and mixed with the stirring A phase to prepare a C phase. To the C phase, a fragrance, component (D), anhydrous silicic acid, and polyoxyethylene hydrogenated castor oil were added, and they were mixed at room temperature using a 1.5 L kneader (manufactured by Ishiyama Works), and the pressure was reduced to 4 kPa to perform defoaming, thereby obtaining 1.0 kg of toothpaste. The blanks in the table indicate that the component is not formulated. The "balance" of purified water indicates the amount that makes the total amount of the oral composition 100%. The following evaluations were performed on the obtained oral compositions. The results are also shown in the table. In each example, it was confirmed by the above method that fluoride ions, calcium ions, and phosphate ions formed a complex.

[0050] <Method for measuring pH> The pH of the oral composition (toothpaste) was the value measured after 3 minutes at 25 °C using a pH meter (model number InLab Routine Pro-ISM) manufactured by METTLER TOLEDO.

[0051] <Evaluation method> [Feeling of effect (fresh feeling in the oral cavity)] Sensory evaluation was performed using 10 professional panelists as subjects. The toothpaste composition filled in a laminated tube was extruded and placed 1 cm on a toothbrush, and toothbrushing was performed for 3 minutes in the same manner as usual. The oral cavity was rinsed with water, and the fresh feeling in the oral cavity immediately after use was scored according to the following scoring criteria. The average value of the scoring results of 10 people was calculated and evaluated according to the following evaluation criteria. When evaluations of ○ and ◎ were obtained, it was determined that the oral composition had an excellent fresh feeling in the oral cavity and a high feeling of effect. (Scoring criteria) 5 points: Very strong feeling of freshness. 4 points: A strong feeling of freshness. 3 points: Refreshing. 2 points: Slightly refreshing. 1 point: Not refreshing. (Evaluation criteria) ◎: Average score of 4.0 points or more. ○: Average score is 3.0 or more but less than 4.0 points. ×: Average score less than 3.0 points.

[0052] [Flavor (no unpleasant taste after use)] A sensory evaluation was conducted using 10 expert panelists as test subjects. The toothpaste composition filled in a laminated tube was squeezed out 1 cm onto a toothbrush, and the subjects brushed their teeth for 3 minutes in the usual way, rinsed their mouths with water, and rated according to the following criteria for the absence of unpleasant taste remaining in the mouth 10 minutes after use. The average of the 10 panelists' ratings was calculated and evaluated according to the following criteria. A rating of ◎ or ○ was given to indicate that the oral composition had a good taste and reduced lingering unpleasant taste after use. (Scoring criteria) 4 points: Not unpleasant at all. 3 points: Slightly unpleasant. 2 points: Feels unpleasant. 1 point: Very strong sense of dislike. (Evaluation criteria) ◎: Average score is 3.5 points or higher. ○: Average value is 3.0 points or more and less than 3.5 points. ×: Average value is less than 3.0 points.

[0053] [Table 1]

[0054] [Table 2]

[0055] [Table 3]

[0056] As shown by the above results, the oral compositions of Examples 1 to 20 were excellent in terms of perceived effect (refreshing feeling in the oral cavity) and flavor (no unpleasant taste after use). On the other hand, Comparative Example 1, which did not contain component (C), and Comparative Example 2, which did not contain component (B), were inferior in flavor (absence of unpleasant taste after use). Comparative Example 3, which did not contain component (D), had an inferior effect (refreshing feeling in the oral cavity).

[0057] <Prescription example> All of the following formulation examples were excellent in terms of perceived effectiveness and flavor (no unpleasant taste after use). <Prescription Example 1: Toothpaste> Sodium fluoride 0.32% Calcium glycerophosphate 0.2% Sodium pyrophosphate 0.1% Sodium bicarbonate 0.5% Silica anhydride 10% Sorbitol solution (concentration 70%) 40% Propylene glycol 3% Xanthan gum 0.5% Sodium polyacrylate 0.5% Coconut oil fatty acid amidopropyl betaine 0.5% Sodium saccharin 0.2% Fragrance composition A 1% Purified water remainder

[0058] <Prescription Example 2: Toothpaste> Sodium fluoride 0.32% Calcium glycerophosphate 0.2% Sodium pyrophosphate 0.1% Sodium carbonate 0.5% Silica anhydride 10% Sorbitol solution (concentration 70%) 40% Propylene glycol 3% Xanthan gum 0.5% Sodium polyacrylate 0.5% Polyoxyethylene hydrogenated castor oil 0.5% Sodium saccharin 0.2% Fragrance composition A 1% Purified water remainder

[0059] <Formulation Example 3: Toothpaste> Sodium fluoride 0.32% Calcium glycerophosphate 0.2% Sodium pyrophosphate 0.1% Sodium bicarbonate 20% Silica anhydride 10% Propylene Glycol 20 Sodium carboxymethylcellulose 1% Xanthan gum 0.5% Polyoxyethylene hydrogenated castor oil 0.5% Fragrance composition A 1% Purified water remainder

[0060] <Formulation Example 5: Liquid toothpaste> Sodium fluoride 0.32% Calcium glycerophosphate 0.2% Tetrapotassium pyrophosphate 0.1% Sodium bicarbonate 0.5% Glycerin 7.5% Propylene glycol 3% Sorbitol solution (70%) 5% Coconut oil fatty acid amidopropyl betaine 0.3% Fragrance composition A 0.2% Purified water remainder

[0061] <Prescription Example 6: Mouthwash> Sodium fluoride 0.1% Calcium glycerophosphate 0.5% Tetrapotassium pyrophosphate 0.1% Sodium bicarbonate 0.5% Glycerin 3% Propylene glycol 2% Sorbitol solution (70%) 3% Fragrance composition A 0.2% Purified water remainder

[0062] Furthermore, in the above prescription examples 1 to 6, dentifrice, liquid dentifrice, or mouthwash were prepared with the same composition except that flavor compositions B to P shown in Tables 4 and 5 below were used instead of flavor composition A. All of them had a good perceived effect and the unpleasant taste was reduced. The compositions of flavors 1 to 7 and solvents described in Tables 4 and 5 are shown in Tables 6 to 13. In the table, "cut a% of the front end" means that the first a% is removed when the essential oil is distilled, and "cut b% of the front and back ends" means that the first b% and the last b% are removed when the essential oil is distilled.

[0063] [Table 4]

[0064] [Table 5]

[0065] [Table 6]

[0066] [Table 7]

[0067] [Table 8]

[0068] [Table 9]

[0069] [Table 10]

[0070] Table 11

[0071] Table 12

[0072] Table 13

Claims

1. (A) sodium fluoride, (B) a water-soluble calcium salt, (C) one or more members selected from the group consisting of condensed phosphoric acid and alkali metal salts thereof, and (D) sodium carbonate and / or sodium bicarbonate; An oral composition comprising:

2. 2. The oral composition according to claim 1, wherein the component (B) comprises one or more selected from the group consisting of calcium chloride, calcium glycerophosphate, calcium gluconate, calcium lactate, and calcium pantothenate.

3. 2. The oral composition according to claim 1, wherein the component (C) comprises at least one member selected from the group consisting of pyrophosphoric acid and alkali metal pyrophosphates.

4. The oral composition according to claim 1, which has a pH of 8 to 11 at 25°C.

5. The oral composition according to any one of claims 1 to 4, which is a dentifrice.

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