Wire and guide wire

Abstract

To prevent a wire from being unintentionally bent.SOLUTION: The wire includes a metal core material having a reduced diameter portion whose diameter is reduced from a first end side toward a second end side in an extending direction of the wire, and a metal covering material covering the reduced diameter portion of the core material.SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] The technology disclosed herein relates to wires and guidewires. [Background technology]

[0002] A known wire includes a first core portion (core material) and an outer shell that covers the first core portion (see, for example, Patent Document 1). [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Special Publication No. 2011-514183 Summary of the Invention [Problem to be solved by the invention]

[0004] The rigidity of the wire changes suddenly at the locations where the ends of the core material are located in the extending direction of the wire, so the wire is prone to unintentional bending.

[0005] This specification discloses a technique that can solve the above-mentioned problems. [Means for solving the problem]

[0006] The technology disclosed in this specification can be realized, for example, in the following forms.

[0007] (1) The wire disclosed in this specification includes a metal core having a tapered portion that tapers from a first end to a second end in the extension direction of the wire, and a metal covering covering the tapered portion of the core. Since the core has the tapered portion, this wire is less likely to change in rigidity in the extension direction of the wire, and is less likely to bend unintentionally.

[0008] (2) In the wire, the reduced diameter portion may be tapered from the first end toward the second end. With this configuration, the tapered reduced diameter portion effectively suppresses changes in rigidity in the extending direction of the wire, and effectively suppresses unintended bending of the wire.

[0009] (3) In the wire, the coating material may have a solid portion closer to the second end than the reduced diameter portion. With this configuration, the coating material has a solid portion, which improves the tensile strength and torsional strength of the wire.

[0010] (4) In the wire, the solid portion may be in contact with the reduced diameter portion. According to this configuration, the solid portion is in contact with the reduced diameter portion, which effectively improves the tensile strength and torsional strength of the wire.

[0011] (5) The wire may have a hollow portion closer to the second end than the reduced diameter portion. With this configuration, the wire has a hollow portion, which improves the flexibility of the wire.

[0012] (6) In the wire, the outer peripheral surface of the reduced diameter portion may have a protrusion protruding radially outward of the wire. According to this configuration, the outer peripheral surface of the reduced diameter portion has a protrusion, which increases the contact area between the core material and the coating material compared to, for example, an embodiment in which the outer peripheral surface of the reduced diameter portion is smooth, thereby improving the bonding strength between the core material and the coating material.

[0013] (7) In the wire, the outer diameter of the reduced diameter portion in the first cross section may be smaller than the outer diameter of the reduced diameter portion in the second cross section, and the number of protrusions on the outer peripheral surface of the reduced diameter portion in the first cross section may be greater than the number of protrusions on the outer peripheral surface of the reduced diameter portion in the second cross section. This configuration further improves the bonding strength between the core material and the coating material.

[0014] (8) In the wire, the core may have a thickened portion having an outer diameter larger than that of the tapered portion, and the thickened portion may have an outer circumferential surface smoother than that of the tapered portion. With this configuration, stress is less likely to concentrate on the thickened portion, thereby preventing the wire from unintentionally bending.

[0015] (9) A guidewire disclosed in the present specification includes the wire according to any one of (1) to (8) above as a core shaft. This guidewire suppresses changes in the rigidity of the wire in the extension direction, and prevents the core shaft from unintentionally bending.

[0016] (10) In the above guidewire, the core material may be a first core material, the reduced diameter portion may be a first reduced diameter portion, and the wire may further comprise a second core material made of metal having a second reduced diameter portion that reduces in diameter from the second end side to the first end side in the extension direction of the wire, the second reduced diameter portion being covered with the coating material, the second core material being located closer to the second end than the first core material, the first reduced diameter portion being located at an end of the first core material closer to the second end, and the second reduced diameter portion being located at an end of the second core material closer to the first end. According to this configuration, since the wire comprises a first core material having a first reduced diameter portion and a second core material having a second reduced diameter portion, changes in rigidity in the extension direction of the wire are effectively suppressed, and unintended bending of the core shaft is effectively suppressed.

[0017] (11) In the above-described guidewire, the first core material and the second core material may be spaced apart from each other in the extension direction of the wire, the first core material and the second core material may be radiopaque, and the covering material may be radiotransparent. According to this configuration, the first core material and the second core material function as radiopaque markers, improving the visibility of the guidewire. This eliminates the need for a radiopaque marker on the outer peripheral surface of the covering material, for example, and thus reduces the deterioration of slidability with other devices (e.g., catheters) used in combination with the guidewire.

[0018] (12) The guide wire may further include a coil covering the distal end of the wire, and the reduced diameter portion may be located closer to the proximal end than the proximal end of the coil. With this configuration, changes in rigidity in the extension direction of the wire are suppressed, and unintended bending of the core shaft is suppressed.

[0019] (13) In the above guidewire, the wire has a first shaft portion located proximal to a proximal end of the coil, and a second shaft portion located proximal to the first shaft portion and having an outer diameter larger than that of the first shaft portion, the core material is a first core material, the reduced diameter portion is a first reduced diameter portion, the wire further has a second reduced diameter portion made of metal and having a second reduced diameter portion whose diameter decreases from the second end side toward the first end side in the extension direction of the wire, and the second reduced diameter portion is a second core material covered with the covering material. The wire may include a covering material, the second core material being located closer to the second end than the first core material, the first reduced diameter portion being located at an end of the first core material closer to the second end, the second reduced diameter portion being located at an end of the second core material closer to the first end, the first core material and the second core material being spaced apart from each other in the extension direction of the wire, the first core material and the second core material being radiopaque, the covering material being radiotransparent, and the first reduced diameter portion and the second reduced diameter portion being located in the first shaft portion of the wire. According to this configuration, the first core material and the second core material function as radiopaque markers, thereby improving the visibility of the guidewire. As a result, the guidewire does not require a radiopaque marker to be provided on, for example, the outer peripheral surface of the covering material, and therefore a decrease in slidability with other devices (e.g., catheters) used in combination with the guidewire is suppressed.

[0020] (14) In the above guidewire, the wire has a first shaft portion located proximal to a proximal end of the coil, and a second shaft portion located proximal to the first shaft portion and having an outer diameter larger than that of the first shaft portion, the core material is a first core material, the reduced diameter portion is a first reduced diameter portion, the wire further has a second reduced diameter portion made of metal and having a second reduced diameter portion whose diameter decreases from the second end side toward the first end side in the extension direction of the wire, and the second reduced diameter portion is a second core material covered with the covering material. The wire may include a covering material, the second core material being located closer to the second end than the first core material, the first reduced diameter portion being located at an end of the first core material closer to the second end, the second reduced diameter portion being located at an end of the second core material closer to the first end, the first core material and the second core material being spaced apart from each other in the extension direction of the wire, the first core material and the second core material being radiopaque, the covering material being radiotransparent, and the first reduced diameter portion and the second reduced diameter portion being located at the second shaft portion of the wire. According to this configuration, the first core material and the second core material function as radiopaque markers, thereby improving the visibility of the guidewire. As a result, the guidewire does not require a radiopaque marker to be provided on, for example, the outer peripheral surface of the covering material, and therefore a decrease in slidability with other devices (e.g., catheters) used in combination with the guidewire is suppressed.

[0021] (15) Another guidewire disclosed in the present specification includes a long core shaft and a coil in which the wire according to any one of (1) to (8) above is wound helically, the coil covering the distal end of the core shaft. This guidewire suppresses changes in stiffness in the extension direction of the wire, and prevents the coil from unintentionally bending.

[0022] (16) In the above guidewire, the core material may be a first core material, the reduced diameter portion may be a first reduced diameter portion, and the wire may further comprise a second core material made of metal having a second reduced diameter portion that reduces in diameter from the second end side to the first end side in the extension direction of the wire, the second reduced diameter portion being covered with the coating material, the second core material being located closer to the second end than the first core material, the first reduced diameter portion being located at an end of the first core material closer to the second end, and the second reduced diameter portion being located at an end of the second core material closer to the first end. According to this configuration, since the wire comprises a first core material having a first reduced diameter portion and a second core material having a second reduced diameter portion, changes in rigidity in the extension direction of the wire are effectively suppressed, and unintended bending of the coil is effectively suppressed.

[0023] (17) In the above-described guidewire, the first core material and the second core material may be spaced apart from each other in the extension direction of the wire, the first core material and the second core material may be radiopaque, and the covering material may be radiotransparent. According to this configuration, the first core material and the second core material function as radiopaque markers, improving the visibility of the guidewire. This eliminates the need for a radiopaque marker on the outer peripheral surface of the covering material, for example, and thus reduces the deterioration of slidability with other devices (e.g., catheters) used in combination with the guidewire.

[0024] The techniques disclosed in this specification can be realized in various forms, such as a wire, a core shaft provided in a guidewire, a coil provided in a guidewire, a guidewire, and a method for manufacturing the same. [Brief explanation of the drawings]

[0025] [Figure 1] FIG. 1 is a longitudinal cross-sectional view of a wire according to a first embodiment; [Figure 2] Cross-sectional view of the wire at position II-II in Figure 1 [Figure 3] Cross-sectional view of the wire at position III-III in Figure 1 [Figure 4] Cross-section of the wire at position IV-IV in Figure 1 [Figure 5] FIG. 10 is a longitudinal cross-sectional view of a wire according to a second embodiment. [Figure 6] FIG. 10 is an explanatory diagram showing a guide wire according to a third embodiment. [Figure 7] FIG. 10 is an enlarged longitudinal cross-sectional view showing the first core material and the second core material of the third embodiment. [Figure 8] FIG. 10 is an enlarged longitudinal cross-sectional view showing the fifth core material and the sixth core material of the third embodiment. [Figure 9] FIG. 10 is an explanatory diagram showing a guide wire according to a fourth embodiment. [Figure 10] FIG. 10 is an enlarged longitudinal cross-sectional view showing the first core material and the second core material of the fourth embodiment. [Figure 11] FIG. 10 is a longitudinal cross-sectional view of a wire according to a first modified example. [Figure 12] FIG. 10 is an enlarged longitudinal cross-sectional view showing a first core material and a second core material of a second modified example. DETAILED DESCRIPTION OF THE INVENTION

[0026] A. First embodiment: (Wire 100 configuration) FIG. 1 is a longitudinal cross-sectional view of a wire 100 according to a first embodiment. In FIG. 1, mutually orthogonal X, Y, and Z axes are shown to identify directions. FIG. 1 shows the wire 100 in a linear state extending in the Z-axis direction as a whole. The wire 100 is flexible enough to be bent. In this embodiment, a longitudinal cross-section refers to a cross-section (YZ cross-section) parallel to the extension direction (Z-axis direction) of the wire 100, and a transverse cross-section refers to a cross-section (XY cross-section) perpendicular to the extension direction of the wire 100. In this embodiment, "same" and "equal" mean roughly the same, allowing for variations due to manufacturing errors and the like. In this embodiment, "constant" also includes roughly constant, allowing for variations due to manufacturing errors and the like. FIG. 1 shows a first end 100D, which is the end on the positive Z-axis side in the Z-axis direction, and a second end 100P, which is the end on the negative Z-axis side in the Z-axis direction.

[0027] The wire 100 is a thin wire made of metal. The use of the wire 100 is not particularly limited. The wire 100 may be, for example, a medical wire. The wire 100 may be, for example, a living body insertion wire to be inserted into a living body lumen such as a blood vessel.

[0028] The wire 100 includes a core material 111 and a covering material 120. The wire 100 may be, for example, a clad material in which the outer peripheral surface of the core material 111 and the inner peripheral surface of the covering material 120 are joined to each other.

[0029] The core 111 is located at the center of the cross section of the wire 100 (see FIGS. 2 to 4). The core 111 extends along the Z-axis direction. The core 111 has a reduced diameter portion 111R and a thicker diameter portion 111T. The reduced diameter portion 111R is a portion whose outer diameter tapers from the first end 100D side to the second end 100P side in the extension direction of the wire 100. The smallest outer diameter of the reduced diameter portion 111R may be, for example, 1 / 100 times or more and 1 / 2 times or less of the largest outer diameter of the reduced diameter portion 111R, or 1 / 6 times or more and 1 / 2 times or less of the largest outer diameter of the reduced diameter portion 111R. The outer diameter of the thicker diameter portion 111T is larger than the outer diameter of the reduced diameter portion 111R. The outer diameter of the large diameter portion 111T is constant from the first end 100D side to the second end 100P side. The large diameter portion 111T is located closer to the first end 100D than the small diameter portion 111R. The large diameter portion 111T is adjacent to the small diameter portion 111R in the Z-axis direction. The outer shape of the cross section of the core material 111 may be any shape. In this embodiment, the outer shape of the cross section of the core material 111 is circular.

[0030] The core material 111 is made of metal. There are no particular limitations on the material of the core material 111 other than that it is metal. The core material 111 may be made of a radiopaque material such as platinum, tantalum, rhenium, or iridium.

[0031] The covering material 120 extends along the Z-axis direction. The covering material 120 covers the reduced diameter portion 111R of the core material 111. In this embodiment, the covering material 120 covers the core material 111 from the end of the core material 111 on the first end 100D side to the end of the core material 111 on the second end 100P side. The covering material 120 abuts against the reduced diameter portion 111R. The covering material 120 covers the entire reduced diameter portion 111R so as to be in close contact with the reduced diameter portion 111R. The outer diameter of the covering material 120 is constant from the first end 100D to the second end 100P. The covering material 120 of this embodiment has a solid portion 120S closer to the second end 100P than the reduced diameter portion 111R. The solid portion 120S abuts against the reduced diameter portion 111R. The outer shape of the cross section of the covering material 120 may be any shape. In this embodiment, the cross-sectional outline of the covering material 120 is circular.

[0032] The covering material 120 is made of metal. The material of the covering material 120 is not particularly limited other than that it is a metal. The material of the covering material 120 may be, for example, a metal different from the metal that is the material of the core material 111. The covering material 120 may be, for example, a radiolucent material such as stainless steel (SUS302, SUS304, SUS316, etc.), a cobalt alloy (Co-Ni, etc.), a Ni-Ti alloy, or Ti. The Young's modulus of the material that constitutes the covering material 120 may be higher than the Young's modulus of the material that constitutes the core material 111.

[0033] FIG. 2 is a cross-sectional view of the wire 100 taken along line II-II in FIG. 1. FIG. 2 shows a cross-section including the reduced diameter portion 111R of the core material 111 (hereinafter referred to as the "first cross-section CS1"). FIG. 3 is a cross-sectional view of the wire 100 taken along line III-III in FIG. 1. FIG. 3 shows a cross-section closer to the first end 100D than the first cross-section CS1 and including the reduced diameter portion 111R of the core material 111 (hereinafter referred to as the "second cross-section CS2"). FIG. 4 is a cross-sectional view of the wire 100 taken along line IV-IV in FIG. 1. FIG. 4 shows a cross-section closer to the first end 100D than the second cross-section CS2 and including the thickened diameter portion 111T of the core material 111 (hereinafter referred to as the "third cross-section CS3").

[0034] The outer diameters of the covering material 120 are equal to one another in the first cross-section CS1, the second cross-section CS2, and the third cross-section CS3. The outer diameter of the core material 111 in the second cross-section CS2 is larger than the outer diameter of the core material 111 in the first cross-section CS1. The outer diameter of the core material 111 in the third cross-section CS3 is larger than the outer diameter of the core material 111 in the second cross-section CS2.

[0035] In the first transverse cross section CS1 and the second transverse cross section CS2, the outer peripheral surface of the core 111 has convex portions 111C that protrude radially outward of the wire 100. That is, the outer peripheral surface of the reduced diameter portion 111R has convex portions 111C that protrude radially outward of the wire 100. The "radial direction" refers to any direction perpendicular to the central axis of the wire 100. In the reduced diameter portion 111R, the number of convex portions 111C on the outer peripheral surface increases as the outer diameter of the core 111 decreases. Therefore, the number of convex portions 111C on the outer peripheral surface of the reduced diameter portion 111R in the first transverse cross section CS1 is greater than the number of convex portions 111C on the outer peripheral surface of the reduced diameter portion 111R in the second transverse cross section CS2. The outer peripheral surface of the large diameter portion 111T does not have a portion corresponding to the convex portions 111C on the outer peripheral surface of the reduced diameter portion 111R. That is, the outer circumferential surface of the large diameter portion 111T is smoother than the outer circumferential surface of the reduced diameter portion 111R.

[0036] (Method of manufacturing the wire 100) The wire 100 can be manufactured by, for example, the following manufacturing method. First, an operator prepares a metal wire material to be used as the core material 111 of the wire 100 and a metal pipe material to be used as the covering material 120 of the wire 100. Next, the operator forms a reduced diameter portion in which the outer diameter of the wire material is reduced in the extension direction of the wire material, for example, by cutting or grinding a portion of the wire material. This reduced diameter portion becomes the reduced diameter portion 111R of the wire 100. Next, the operator joins the wire material and the pipe material. More specifically, the operator passes the wire material through the pipe material and performs a wiredrawing process while the wire material and the pipe material are joined together. At this time, the operator prepares multiple wiredrawing dies with through holes of different sizes and passes the wire material and the pipe material through the wiredrawing die in order, starting with the wire drawing die with the largest through hole size. As a result, the outer diameter of the pipe material gradually reduces, and eventually the pipe material and the wire material come into close contact with each other, integrating the pipe material and the core wire, and forming a clad material. The clad material thus produced is then processed to any desired length. Through the above steps, wire 100 is manufactured.

[0037] (Effects of the first embodiment) As described above, the wire 100 of this embodiment includes the metal core 111 having the reduced diameter portion 111R that reduces in diameter from the first end 100D side to the second end 100P side in the extension direction of the wire 100, and the metal covering material 120 that covers the reduced diameter portion 111R of the core 111. According to the wire 100 of this embodiment, because the core 111 has the reduced diameter portion 111R, changes in rigidity in the extension direction of the wire 100 are suppressed, and the wire 100 is suppressed from being unintentionally bent.

[0038] In the wire 100 of this embodiment, the reduced diameter portion 111R tapers in diameter from the first end 100D side toward the second end 100P side. According to the wire 100 of this embodiment, since the reduced diameter portion 111R tapers in diameter, a change in rigidity in the extension direction of the wire 100 is effectively suppressed, and unintentional bending of the wire 100 is effectively suppressed.

[0039] In the wire 100 of this embodiment, the covering material 120 has a solid portion 120S closer to the second end 100P than the reduced diameter portion 111R. According to the wire 100 of this embodiment, since the covering material 120 has the solid portion 120S, the tensile strength and torsional strength of the wire 100 are improved.

[0040] In the wire 100 of this embodiment, the solid portion 120S abuts against the reduced diameter portion 111R. According to the wire 100 of this embodiment, since the solid portion 120S abuts against the reduced diameter portion 111R, the tensile strength and torsional strength of the wire 100 are effectively improved.

[0041] In wire 100 of this embodiment, the outer peripheral surface of reduced diameter portion 111R has protrusions 111C that protrude radially outward of wire 100. According to wire 100 of this embodiment, because the outer peripheral surface of reduced diameter portion 111R has protrusions 111C, the contact area between core material 111 and coating material 120 is increased compared to, for example, an embodiment in which the outer peripheral surface of reduced diameter portion 111R is smooth, and the bonding strength between core material 111 and coating material 120 is improved.

[0042] In the wire 100 of this embodiment, the outer diameter of the reduced diameter portion 111R in the first cross section CS1 is smaller than the outer diameter of the reduced diameter portion 111R in the second cross section CS2, and the number of convex portions 111C on the outer peripheral surface of the reduced diameter portion 111R in the first cross section CS1 is greater than the number of convex portions 111C on the outer peripheral surface of the reduced diameter portion 111R in the second cross section CS2. According to the wire 100 of this embodiment, the bonding strength between the core material 111 and the coating material 120 is further improved.

[0043] In the wire 100 of this embodiment, the core 111 has a thick diameter portion 111T having an outer diameter larger than that of the narrowed diameter portion 111R, and the outer peripheral surface of the thick diameter portion 111T is smoother than that of the narrowed diameter portion 111R. According to the wire 100 of this embodiment, stress is less likely to concentrate on the thick diameter portion 111T, and therefore, the wire 100 is prevented from unintentionally bending.

[0044] B. Second embodiment: (Configuration of wire 100a) 5 is a longitudinal cross-sectional view of the wire 100a of the second embodiment. In the following, among the components of the wire 100a of the present embodiment, components common to the wire 100 of the first embodiment are denoted by the same reference numerals and description thereof will be omitted as appropriate.

[0045] The wire 100a of this embodiment differs from the first embodiment in the configuration of the coating material 120a. The coating material 120a does not have a portion corresponding to the solid portion 120S of the coating material 120 of the first embodiment. In other words, the wire 100a has a hollow portion 100H closer to the second end 100P than the reduced diameter portion 111R. In this embodiment, the outer peripheral surface of the reduced diameter portion 111R does not contact the inner peripheral surface of the coating material 120a. A gap is formed between the outer peripheral surface of the reduced diameter portion 111R and the inner peripheral surface of the coating material 120a.

[0046] (Effects of the second embodiment) As described above, the wire 100a of this embodiment has the hollow portion 100H closer to the second end 100P than the reduced diameter portion 111R of the wire 100a. According to the wire 100a of this embodiment, the wire 100a has the hollow portion 100H, which improves the flexibility of the wire 100a.

[0047] C. Third embodiment: (Configuration of guidewire 10) FIG. 6 is an explanatory diagram showing a guidewire 10 according to a third embodiment. FIG. 6 shows a longitudinal cross section of the wire 100b and side views of the coil 30, the distal joint 40, and the proximal joint 50. In FIG. 6, the positive Z-axis direction corresponds to the distal end (distal side) inserted into the body, and the negative Z-axis direction corresponds to the proximal end (proximal side) manipulated by the operator. FIG. 6 shows the guidewire 10 as a whole in a linear shape substantially parallel to the Z-axis direction. The guidewire 10 is flexible enough to be bent. Hereinafter, the distal end of the guidewire 10 and each of its components will be referred to as the "distal end," the distal end and its vicinity as the "distal portion," the proximal end as the "proximal end," and the proximal end and its vicinity as the "proximal portion." In this embodiment, "same" and "equal" mean roughly the same, allowing for variations due to manufacturing errors and the like. In this embodiment, "constant" also includes being roughly constant, and allows for fluctuations due to manufacturing errors and the like.

[0048] The guidewire 10 is a medical device that is inserted into a biological lumen such as a blood vessel. The guidewire 10 is used, for example, to guide another medical device such as a catheter to a desired position within the biological lumen. The total length of the guidewire 10 is, for example, approximately 1500 mm or more and 3000 mm or less.

[0049] The guidewire 10 includes a wire 100b, a coil 30, a distal joint 40, and a proximal joint 50.

[0050] The wire 100b extends along the Z-axis direction. The wire 100b is a core shaft provided in the guidewire 10. A first end 100D of the wire 100b is located on the distal end side of the guidewire 10, and a second end 100P of the wire 100b is located on the proximal end side of the guidewire 10. That is, in this specification, the distal end of the wire 100b is synonymous with the first end 100D, and the proximal end of the wire 100b is synonymous with the second end 100P.

[0051] The wire 100b has a first shaft portion 101 and a second shaft portion 102 that extend in the extension direction of the wire 100b. The first shaft portion 101 is located closer to the base end than the base end of the coil 30. In this embodiment, the outer diameter of the first shaft portion 101 tapers from the base end toward the tip end. The second shaft portion 102 is located closer to the base end than the base end of the first shaft portion 101. The outer diameter of the second shaft portion 102 is constant from the base end toward the tip end. The outer diameter of the second shaft portion 102 is larger than the outer diameter of the first shaft portion 101. In this embodiment, the second shaft portion 102 is the portion of the wire 100b where the outer diameter is largest.

[0052] The wire 100b includes a first core material 111b, a second core material 112b, a third core material 113b, a fourth core material 114b, a fifth core material 115b, a sixth core material 116b, and a covering material 120b.

[0053] The first core material 111b, the second core material 112b, the third core material 113b, the fourth core material 114b, the fifth core material 115b, and the sixth core material 116b are each located at the center of the cross section of the wire 100b. The first core material 111b, the second core material 112b, the third core material 113b, the fourth core material 114b, the fifth core material 115b, and the sixth core material 116b each extend along the Z-axis direction. The first core material 111b, the second core material 112b, the third core material 113b, the fourth core material 114b, the fifth core material 115b, and the sixth core material 116b are arranged in this order from the distal end to the proximal end of the wire 100b. The first core material 111b, the second core material 112b, the third core material 113b, and the fourth core material 114b are located in the first shaft portion 101 of the wire 100b. The fifth core material 115b and the sixth core material 116b are located in the second shaft portion 102 of the wire 100b.

[0054] The distal end portion of each of the first core 111b, the second core 112b, the third core 113b, the fourth core 114b, the fifth core 115b, and the sixth core 116b has an outer diameter that tapers from the second end 100P side toward the first end 100D side. The proximal end portion of each of the first core 111b, the second core 112b, the third core 113b, the fourth core 114b, the fifth core 115b, and the sixth core 116b has an outer diameter that tapers from the first end 100D side toward the second end 100P side. The outer shape of the cross section of each of the first core 111b, the second core 112b, the third core 113b, the fourth core 114b, the fifth core 115b, and the sixth core 116b may have any shape. In this embodiment, the cross-sectional shape of each of first core 111b, second core 112b, third core 113b, fourth core 114b, fifth core 115b and sixth core 116b is circular.

[0055] The first core material 111b, the second core material 112b, the third core material 113b, the fourth core material 114b, the fifth core material 115b, and the sixth core material 116b are each made of a metal. The material of the first core material 111b, the second core material 112b, the third core material 113b, the fourth core material 114b, the fifth core material 115b, and the sixth core material 116b is not particularly limited other than being a metal. In this embodiment, the first core material 111b, the second core material 112b, the third core material 113b, the fourth core material 114b, the fifth core material 115b, and the sixth core material 116b are each made of a radiopaque material such as platinum, tantalum, rhenium, or iridium. The first core material 111b, the second core material 112b, the third core material 113b, the fourth core material 114b, the fifth core material 115b, and the sixth core material 116b may be made of the same material or different materials.

[0056] The covering material 120b extends along the Z-axis direction. The covering material 120b extends from the tip of the first core material 111b to the base end of the sixth core material 116b, covering the first core material 111b, the second core material 112b, the third core material 113b, the fourth core material 114b, the fifth core material 115b, and the sixth core material 116b. The covering material 120b in the first shaft portion 101 has an outer diameter that tapers from the second end 100P side toward the first end 100D side. The covering material 120b in the second shaft portion 102 has a constant outer diameter from the first end 100D side toward the second end 100P side. The cross-sectional shape of the covering material 120b may be any shape. In this embodiment, the cross-sectional shape of the covering material 120b is circular.

[0057] The covering material 120b is made of metal. The material of the covering material 120b is not particularly limited except that it is a metal. The material of the covering material 120b may be, for example, a metal different from the metal used to form the first core material 111b, the second core material 112b, the third core material 113b, the fourth core material 114b, the fifth core material 115b, and the sixth core material 116b. In this embodiment, the covering material 120b is a radiolucent material such as stainless steel (SUS302, SUS304, SUS316, etc.), a cobalt alloy (Co-Ni, etc.), a Ni-Ti alloy, or Ti. The Young's modulus of the material forming the covering material 120b may be higher than the Young's modulus of the material forming the first core material 111b. Details of the wire 100b will be described later.

[0058] The coil 30 is a coil-shaped member formed into a hollow cylinder. The coil 30 extends in the Z-axis direction. The coil 30 covers the tip of the wire 100b. The material of the coil 30 is not particularly limited. The coil 30 is formed from, for example, stainless steel (SUS302, SUS304, SUS316, etc.), Ni-Ti alloy, piano wire, platinum, gold, tungsten, cobalt alloy, nickel-chromium metal, etc.

[0059] The distal joint 40 is a member that joins the distal end of the wire 100b to the distal end of the coil 30. The proximal joint 50 is a member that joins the wire 100b to the proximal end of the coil 30 at a predetermined position proximal to the distal end of the wire 100b. The materials of the distal joint 40 and the proximal joint 50 are not particularly limited. The distal joint 40 and the proximal joint 50 are formed, for example, from metal solder (Au—Sn alloy, Sn—Ag alloy, Sn—Pb alloy, Pb—Ag alloy, etc.), brazing material (aluminum alloy brazing, silver brazing, gold brazing, etc.), adhesive (epoxy adhesive, etc.), etc. The distal joint 40 and the proximal joint 50 may be formed from the same material or from different materials.

[0060] (Detailed configuration of wire 100b) 7 is an enlarged longitudinal cross-sectional view of the first core material 111b and the second core material 112b of the third embodiment. The first core material 111b has a reduced diameter portion 111Rb whose outer diameter tapers from the first end 100D toward the second end 100P in the extension direction of the wire 100b. The reduced diameter portion 111Rb is located closer to the base end than the base end of the coil 30. The second core material 112b has a reduced diameter portion 112Rb whose outer diameter tapers from the second end 100P toward the first end 100D in the extension direction of the wire 100b.

[0061] The second core material 112b is located closer to the second end 100P than the first core material 111b. The reduced diameter portion 111Rb is located at the end of the first core material 111b on the second end 100P side. The reduced diameter portion 112Rb is located at the end of the second core material 112b on the first end 100D side. The first core material 111b and the second core material 112b are spaced apart from each other in the extension direction of the wire 100. A solid portion 120Sb of the coating material 120b is disposed between the first core material 111b and the second core material 112b in the extension direction of the wire 100. The solid portion 120Sb is in contact with both the reduced diameter portion 111Rb and the reduced diameter portion 112Rb. The reduced diameter portion 111Rb is an example of a first reduced diameter portion. The reduced diameter portion 112Rb is an example of a second reduced diameter portion.

[0062] 8 is an enlarged longitudinal cross-sectional view of the fifth core material 115b and the sixth core material 116b of the third embodiment. The fifth core material 115b has a reduced diameter portion 115Rb whose outer diameter tapers from the first end 100D toward the second end 100P in the extension direction of the wire 100b. The sixth core material 116b has a reduced diameter portion 116Rb whose outer diameter tapers from the second end 100P toward the first end 100D in the extension direction of the wire 100b.

[0063] The sixth core material 116b is located closer to the second end 100P than the fifth core material 115b. The reduced diameter portion 115Rb is located at the end of the fifth core material 115b closer to the second end 100P. The reduced diameter portion 116Rb is located at the end of the sixth core material 116b closer to the first end 100D. The fifth core material 115b and the sixth core material 116b are spaced apart from each other in the extension direction of the wire 100. A solid portion 120Sb of the covering material 120b is disposed between the fifth core material 115b and the sixth core material 116b in the extension direction of the wire 100. The solid portion 120Sb is in contact with both the reduced diameter portion 115Rb and the reduced diameter portion 116Rb. The fifth core material 115b is an example of a first core material. The sixth core material 116b is an example of a second core material. The reduced diameter portion 115Rb is an example of a first reduced diameter portion, and the reduced diameter portion 116Rb is an example of a second reduced diameter portion.

[0064] (Effects of the third embodiment) As described above, the guidewire 10 of this embodiment includes the wire 100b as a core shaft. According to the guidewire 10 of this embodiment, change in rigidity of the wire 100b in the extension direction is suppressed, and unintentional bending of the core shaft is suppressed.

[0065] In the guide wire 10 of this embodiment, the core material is a first core material 111b, the reduced diameter portion is a reduced diameter portion 111Rb, and the wire 100b further comprises a second core material 112b made of metal having a reduced diameter portion 112Rb that reduces in diameter from the second end 100P side toward the first end 100D side in the extension direction of the wire 100b, and the reduced diameter portion 112Rb is covered with a coating material 120b, and the second core material 112b is located closer to the second end 100P than the first core material 111b, the reduced diameter portion 111Rb is located at the end of the first core material 111b on the second end 100P side, and the reduced diameter portion 112Rb is located at the end of the second core material 112b on the first end 100D side. According to the guide wire 10 of this embodiment, the wire 100b comprises a first core material 111b having a reduced diameter portion 111Rb and a second core material 112b having a reduced diameter portion 112Rb, thereby effectively suppressing changes in rigidity in the extension direction of the wire 100b and effectively suppressing unintentional bending of the core shaft.

[0066] In the guidewire 10 of this embodiment, the first core material 111b and the second core material 112b are spaced apart from each other in the extension direction of the wire 100b, the first core material 111b and the second core material 112b are radiopaque, and the covering material 120b is radiotransparent. According to the guidewire 10 of this embodiment, the first core material 111b and the second core material 112b function as radiopaque markers, thereby improving the visibility of the guidewire 10. As a result, the guidewire 10 does not require a radiopaque marker to be provided on, for example, the outer peripheral surface of the covering material 120b, and therefore, a decrease in slidability with other devices (e.g., catheters) used in combination with the guidewire 10 is suppressed.

[0067] The guidewire 10 of this embodiment further includes a coil 30 covering the distal end of the wire 100b, and the reduced diameter portion 111Rb is located closer to the proximal end than the proximal end of the coil 30. According to the guidewire 10 of this embodiment, changes in rigidity in the extension direction of the wire 100b are suppressed, and unintentional bending of the core shaft is suppressed.

[0068] In the guidewire 10 of this embodiment, the wire 100b has a first shaft portion 101 located closer to the proximal end than the proximal end of the coil 30, and a second shaft portion 102 located closer to the proximal end than the first shaft portion 101 and having an outer diameter larger than that of the first shaft portion 101. The core material is a first core material 111b, and the reduced diameter portion is a reduced diameter portion 111Rb. The wire 100b further has a second core material 112b made of metal having a reduced diameter portion 112Rb that reduces in diameter from the second end 100P side toward the first end 100D side in the extension direction of the wire 100b, and the reduced diameter portion 112Rb is covered with a covering material 120b. The second core material 112b is located closer to the second end 100P than the first core material 111b, the reduced diameter portion 111Rb is located at the end of the first core material 111b on the second end 100P side, the reduced diameter portion 112Rb is located at the end of the second core material 112b on the first end 100D side, the first core material 111b and the second core material 112b are spaced apart from each other in the extension direction of the wire 100b, the first core material 111b and the second core material 112b are radiopaque, the covering material 120b is radiotransparent, and the reduced diameter portion 111Rb and the reduced diameter portion 112Rb are located in the first shaft portion 101 of the wire 100b. According to the guidewire 10 of this embodiment, the first core material 111b and the second core material 112b function as radiopaque markers, thereby improving the visibility of the guidewire 10. As a result, the guidewire 10 does not require a radiopaque marker to be provided on the outer peripheral surface of the covering material 120b, for example, and therefore deterioration in slidability between the guidewire 10 and other devices (e.g., catheters) used in combination with the guidewire 10 is suppressed.

[0069] In the guidewire 10 of this embodiment, the wire 100b has a first shaft portion 101 located closer to the proximal end than the proximal end of the coil 30, and a second shaft portion 102 located closer to the proximal end than the first shaft portion 101 and having an outer diameter larger than that of the first shaft portion 101, the core material is a fifth core material 115b, the reduced diameter portion is a reduced diameter portion 115Rb, the wire 100b further has a sixth core material 116b made of metal having a reduced diameter portion 116Rb that reduces in diameter from the second end 100P side to the first end 100D side in the extension direction of the wire 100b, and the reduced diameter portion 116Rb is covered with a covering material 120b. The sixth core material 116b is located closer to the second end 100P than the fifth core material 115b, the reduced diameter portion 115Rb is located at the end of the fifth core material 115b on the second end 100P side, the reduced diameter portion 116Rb is located at the end of the sixth core material 116b on the first end 100D side, the fifth core material 115b and the sixth core material 116b are spaced apart from each other in the extension direction of the wire 100b, the fifth core material 115b and the sixth core material 116b are radiopaque, the covering material 120b is radiotransparent, and the reduced diameter portion 115Rb and the reduced diameter portion 116Rb are located in the second shaft portion 102 of the wire 100b. According to the guidewire 10 of this embodiment, the fifth core material 115b and the sixth core material 116b function as radiopaque markers, thereby improving the visibility of the guidewire 10. As a result, the guidewire 10 does not require a radiopaque marker to be provided on the outer peripheral surface of the covering material 120b, for example, and therefore deterioration in slidability with other devices (e.g., catheters) used in combination with the guidewire 10 is suppressed.

[0070] D. Fourth embodiment: (Configuration of guidewire 10c) 9 is an explanatory diagram showing a guidewire 10c of the fourth embodiment. In the following, among the components of the guidewire 10c of this embodiment, components common to the guidewire 10 of the third embodiment are denoted by the same reference numerals, and description thereof will be omitted as appropriate.

[0071] The guidewire 10c of this embodiment includes a core shaft 20 in place of the wire 100b of the third embodiment, and a wire 100c in place of the coil 30 of the third embodiment.

[0072] The core shaft 20 is an elongated member extending along the Z-axis direction. The cross section of the core shaft 20 can have any shape. For example, the cross section of the core shaft 20 has a circular shape. The material of the core shaft 20 is not particularly limited. The core shaft 20 is formed from, for example, stainless steel (SUS302, SUS304, SUS316, etc.), Ni-Ti alloy, piano wire, nickel-chromium alloy, cobalt alloy, tungsten, etc.

[0073] The wire 100c is a coil-shaped member formed into a hollow cylinder by being wound helically in the Z-axis direction. The wire 100c is a coil provided in the guidewire 10c. The wire 100c covers the distal end of the core shaft 20. A first end 100D of the wire 100c is located on the distal side of the guidewire 10, and a second end 100P of the wire 100c is located on the proximal side of the guidewire 10. That is, in this specification, the distal end of the wire 100c is synonymous with the first end 100D, and the proximal end of the wire 100c is synonymous with the second end 100P.

[0074] The wire 100c includes a first core material 111c, a second core material 112c, and a covering material 120c.

[0075] The first core material 111c and the second core material 112c each extend spirally along the Z-axis direction. The first core material 111c and the second core material 112c are each located at the center of the cross section of the wire 100c. The first core material 111c and the second core material 112c are arranged in this order from the distal end to the proximal end of the wire 100c. The outer shape of the cross section of each of the first core material 111c and the second core material 112c may be any shape. In this embodiment, the outer shape of the cross section of each of the first core material 111c and the second core material 112c is circular.

[0076] The first core material 111c and the second core material 112c are each made of a metal. The material of the first core material 111c and the second core material 112c is not particularly limited except that it is a metal. In this embodiment, the first core material 111c and the second core material 112c are each made of a radiopaque material such as platinum, tantalum, rhenium, or iridium. The first core material 111c and the second core material 112c may be made of the same material or different materials.

[0077] The covering material 120c extends spirally along the Z-axis direction. The covering material 120c extends from the distal end of the first core material 111c to the proximal end of the second core material 112c, covering the first core material 111c and the second core material 112c. The cross-sectional shape of the covering material 120c may be any shape. In this embodiment, the cross-sectional shape of the covering material 120c is circular.

[0078] The covering material 120c is made of metal. The material of the covering material 120c is not particularly limited other than that it is a metal. The material of the covering material 120c may be, for example, a metal different from the metal that is the material of the first core material 111c and the second core material 112c. In this embodiment, the covering material 120c is a radiolucent material such as stainless steel (SUS302, SUS304, SUS316, etc.), cobalt alloy (Co-Ni, etc.), Ni-Ti alloy, Ti, etc. The Young's modulus of the material that makes up the covering material 120c may be higher than the Young's modulus of the material that makes up the first core material 111c.

[0079] (Detailed configuration of Wire 100c) 10 is an enlarged longitudinal cross-sectional view of a first core 111c and a second core 112c according to the fourth embodiment. The first core 111c has a reduced diameter portion 111Rc whose outer diameter tapers from the first end 100D toward the second end 100P in the extension direction of the wire 100c. The second core 112c has a reduced diameter portion 112Rc whose outer diameter tapers from the second end 100P toward the first end 100D in the extension direction of the wire 100c.

[0080] The second core material 112c is located closer to the second end 100P than the first core material 111c. The reduced diameter portion 111Rc is located at the end of the first core material 111c closer to the second end 100P. The reduced diameter portion 112Rc is located at the end of the second core material 112c closer to the first end 100D. The first core material 111c and the second core material 112c are spaced apart in the extension direction of the wire 100. A solid portion 120Sc of the coating material 120c is disposed between the first core material 111c and the second core material 112c in the extension direction of the wire 100. The solid portion 120Sc is in contact with both the reduced diameter portion 111Rc and the reduced diameter portion 112Rc. The reduced diameter portion 111Rc is an example of a first reduced diameter portion. The reduced diameter portion 112Rc is an example of a second reduced diameter portion.

[0081] (Effects of the fourth embodiment) As described above, the guidewire 10c of this embodiment includes the long core shaft 20 and a coil in which the wire 100c is wound helically and covers the distal end of the core shaft 20. According to the guidewire 10c of this embodiment, changes in rigidity in the extension direction of the wire 100c are suppressed, and unintended bending of the coil is suppressed.

[0082] In the guide wire 10c of this embodiment, the core material is a first core material 111c, the reduced diameter portion is a reduced diameter portion 111Rc, and the wire 100c further comprises a metal second core material 112c having a reduced diameter portion 112Rc that reduces in diameter from the second end 100P side toward the first end 100D side in the extension direction of the wire 100c, and the second core material 112c has a reduced diameter portion 112Rc covered with a coating material 120c, the second core material 112c is located closer to the second end 100P than the first core material 111c, the reduced diameter portion 111Rc is located at the end of the first core material 111c on the second end 100P side, and the reduced diameter portion 112Rc is located at the end of the second core material 112c at the first end 100D. According to the guide wire 10c of this embodiment, the wire 100c comprises a first core material 111c having a reduced diameter portion 111Rc and a second core material 112c having a reduced diameter portion 112Rc, thereby effectively suppressing changes in rigidity in the extension direction of the wire 100c and effectively suppressing unintentional bending of the coil.

[0083] In the guidewire 10c of this embodiment, the first core material 111c and the second core material 112c are spaced apart from each other in the extension direction of the wire 100c, the first core material 111c and the second core material 112c are radiopaque, and the covering material 120c is radiotransparent. According to the guidewire 10c of this embodiment, the first core material 111c and the second core material 112c function as radiopaque markers, thereby improving the visibility of the guidewire. As a result, the guidewire 10c does not require a radiopaque marker to be provided on, for example, the outer peripheral surface of the covering material 120c, and therefore, a decrease in slidability with other devices (e.g., catheters) used in combination with the guidewire 10c is suppressed.

[0084] E. Variations: The technology disclosed in this specification is not limited to the above-described embodiments, and can be modified into various forms without departing from the spirit thereof, for example, the following modifications are also possible.

[0085] 11 is a longitudinal cross-sectional view of the wire 100d of the first modified example. In the following, among the components of the wire 100d of the first modified example, components common to the wire 100 of the first embodiment are denoted by the same reference numerals and description thereof will be omitted as appropriate.

[0086] In the wire 100d of the first modified example, the shape of the reduced diameter portion 111Rd in the first core material 111d is different from the shape of the reduced diameter portion 111R in the first embodiment. The reduced diameter portion 111Rd has an outer diameter that gradually decreases from the first end 100D side toward the second end 100P side in a longitudinal cross section of the wire 100d. A solid portion 120Sd in the coating material 120d is in contact with the reduced diameter portion 111Rd.

[0087] As in the first modified example, the first reduced diameter portion does not necessarily have to have an outer diameter that tapers from the first end side toward the second end side.

[0088] 12 is an enlarged longitudinal cross-sectional view of the first core material 111e and the second core material 112e of the second modified example. The wire 100e of the second modified example differs from the wire 100b of the third embodiment in that the first core material 111e and the second core material 112e are continuous in the extension direction of the wire 100e. The reduced diameter portion 111Re is located at the end of the first core material 111e on the second end 100P side. The reduced diameter portion 112Re is located at the end of the second core material 112e on the first end 100D side. The first core material 111e and the second core material 112e are adjacent in the extension direction of the wire 100e. The coating material 120e does not have a portion equivalent to the solid portion 120Sb of the coating material 120b of the third embodiment.

[0089] As in the second modified example, the first core material and the second core material may be adjacent to each other in the extension direction of the wire. The embodiment in which the first core material and the second core material are adjacent to each other in the extension direction of the wire may be applied to a wire used as a core shaft of a guidewire, or may be applied to a wire used as a coil of a guidewire.

[0090] The solid portion of the covering material does not necessarily have to be in contact with the first reduced diameter portion.

[0091] The outer circumferential surface of the first reduced diameter portion does not necessarily have to have a convex portion.The outer circumferential surface of the large diameter portion in the cross section of the wire does not necessarily have to be smooth, and may have a convex portion.

[0092] The wire does not necessarily have to be a core shaft provided in a guidewire, and it does not necessarily have to be a coil provided in a guidewire.

[0093] The first core material and the second core material do not necessarily have to be radiopaque. The covering material does not necessarily have to be radiotransparent.

[0094] All of the features described in each of the above-described embodiments may be combined with other embodiments or modified versions as appropriate. All of the features described in each of the above-described modified versions may be combined with an embodiment or modified version as appropriate. All of the features described in each of the above-described embodiments may be omitted as appropriate. All of the features described in each of the above-described modified versions may be omitted as appropriate.

Claims

1. A wire (100), a metal core (111) having a tapered portion (111R) whose diameter is tapered from a first end (100D) side toward a second end (100P) side in the extending direction of the wire (100); a metallic covering material (120) that covers the reduced diameter portion (111R) of the core material (111); A wire (100).

2. 2. The wire (100) of claim 1, The wire (100) has a tapered diameter that decreases from the first end (100D) toward the second end (100P).

3. A wire (100) according to claim 1 or claim 2, The wire (100) has a solid portion (120S) in the covering material (120) closer to the second end (100P) than the reduced diameter portion (111R).

4. 4. A wire (100) according to claim 3, The solid portion (120S) of the wire (100) abuts against the reduced diameter portion (111R).

5. A wire (100a) according to claim 1 or claim 2, The wire (100a) has a hollow portion (100H) closer to the second end (100P) than the reduced diameter portion (111R) of the wire (100a).

6. A wire (100) according to any one of claims 1 to 5, The wire (100) has a convex portion (111C) on the outer circumferential surface of the reduced diameter portion (111R) that protrudes radially outward of the wire (100).

7. 7. A wire (100) according to claim 6, The wire (100) has an outer diameter in a first cross-section (CS1) of the reduced diameter portion (111R) that is smaller than an outer diameter in a second cross-section (CS2) of the reduced diameter portion (111R), and the number of convex portions (111C) on the outer peripheral surface of the reduced diameter portion (111R) in the first cross-section (CS1) is greater than the number of convex portions (111C) on the outer peripheral surface of the reduced diameter portion (111R) in the second cross-section (CS2).

8. A wire (100) according to claim 6 or claim 7, The core (111) has a large-diameter portion (111T) having an outer diameter larger than the outer diameter of the reduced-diameter portion (111R), The wire (100) has an outer circumferential surface of the large diameter portion (111T) that is smoother than an outer circumferential surface of the reduced diameter portion (111R).

9. A guidewire (10), A guidewire (10) comprising a wire (100b) according to any one of claims 1 to 8 as a core shaft.

10. 10. A guidewire (10) according to claim 9, The core material (111b) is a first core material (111b), the reduced diameter portion (111Rb) is a first reduced diameter portion (111Rb), The wire (100b) further comprises a second core material (112b) made of metal having a second reduced diameter portion (112Rb) whose diameter decreases from the second end (100P) side toward the first end (100D) side in the extension direction of the wire (100b), and the second reduced diameter portion (112Rb) is covered with the covering material (120b), the second core (112b) is located closer to the second end (100P) than the first core (111b), the first reduced diameter portion (111Rb) is located at an end portion of the first core material (111b) on the second end (100P) side, The guide wire (10), wherein the second reduced diameter portion (112Rb) is located at an end of the second core member (112b) on the side of the first end (100D).

11. 11. A guidewire (10) according to claim 10, The first core material (111b) and the second core material (112b) are spaced apart from each other in the extending direction of the wire (100b), the first core material (111b) and the second core material (112b) are radiopaque; The coating (120b) of the guidewire (10) is radiolucent.

12. 10. The guidewire (10) of claim 9, further comprising: a coil (30) covering the tip of the wire (100b); The guidewire (10) is configured such that the reduced diameter portion (111Rb) is located closer to the proximal end than the proximal end of the coil (30).

13. 13. A guidewire (10) according to claim 12, comprising: The wire (100b) a first shaft portion (101) located closer to the base end than the base end of the coil (30); a second shaft portion (102) located closer to the base end than the first shaft portion (101) and having an outer diameter larger than that of the first shaft portion (101); The core material (111b) is a first core material (111b), the reduced diameter portion (111Rb) is a first reduced diameter portion (111Rb), The wire (100b) further comprises a second core material (112b) made of metal having a second reduced diameter portion (112Rb) whose diameter decreases from the second end (100P) side toward the first end (100D) side in the extension direction of the wire (100b), and the second reduced diameter portion (112Rb) is covered with the covering material (120b), the second core (112b) is located closer to the second end (100P) than the first core (111b), the first reduced diameter portion (111Rb) is located at an end portion of the first core material (111b) on the second end (100P) side, the second reduced diameter portion (112Rb) is located at an end portion of the second core material (112b) on the first end (100D) side, The first core material (111b) and the second core material (112b) are spaced apart from each other in the extending direction of the wire (100b), the first core material (111b) and the second core material (112b) are radiopaque; the coating material (120b) is radiolucent; The guide wire (10), wherein the first reduced diameter portion (111Rb) and the second reduced diameter portion (112Rb) are located in the first shaft portion (101) of the wire (100b).

14. 13. A guidewire (10) according to claim 12, comprising: The wire (100b) a first shaft portion (101) located closer to the base end than the base end of the coil (30); a second shaft portion (102) located closer to the base end than the first shaft portion (101) and having an outer diameter larger than that of the first shaft portion (101); The core (115b) is a first core (115b), the reduced diameter portion (115Rb) is a first reduced diameter portion (115Rb), The wire (100b) further comprises a second core material (116b) made of metal having a second reduced diameter portion (116Rb) whose diameter decreases from the second end (100P) side toward the first end (100D) side in the extension direction of the wire (100b), the second reduced diameter portion (116Rb) being covered with the covering material (120b); the second core (116b) is located closer to the second end (100P) than the first core (115b), the first reduced diameter portion (115Rb) is located at an end portion of the first core material (115b) on the second end (100P) side, the second reduced diameter portion (116Rb) is located at an end portion of the second core material (116b) on the first end (100D) side, The first core material (115b) and the second core material (116b) are spaced apart from each other in the extending direction of the wire (100b), the first core (115b) and the second core (116b) are radiopaque; the coating material (120b) is radiolucent; The guide wire (10), wherein the first reduced diameter portion (115Rb) and the second reduced diameter portion (116Rb) are located in the second shaft portion (102) of the wire (100b).

15. A guidewire (10c), A long core shaft (20); a coil in which the wire (100c) according to any one of claims 1 to 8 is wound in a spiral shape, the coil covering the tip of the core shaft (20); A guidewire (10c) comprising:

16. 16. A guidewire (10c) according to claim 15, The core material (111c) is a first core material (111c), the reduced diameter portion (111Rc) is a first reduced diameter portion (111Rc), The wire (100c) further comprises a second core material (112c) made of metal having a second reduced diameter portion (112Rc) whose diameter is reduced from the second end (100P) side toward the first end (100D) side in the extension direction of the wire (100c), the second reduced diameter portion (112Rc) being covered with the covering material (120c), the second core (112c) is located closer to the second end (100P) than the first core (111c), the first reduced diameter portion (111Rc) is located at an end portion of the first core material (111c) on the second end (100P) side, The guide wire (10c), wherein the second reduced diameter portion (112Rc) is located at an end of the second core member (112c) on the side of the first end (100D).

17. 17. A guidewire (10c) according to claim 16, The first core material (111c) and the second core material (112c) are spaced apart from each other in the extending direction of the wire (100c), The first core material (111c) and the second core material (112c) are radiopaque, The coating (120c) is radiolucent.

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