Composition comprising (BIO) - alkanediols with antimicrobial properties for product protection

Abstract

To provide a composition comprising or consisting of an alkanediol or a synergistic combination of a mixture of two or more different specific alkanediols, and to provide the use of the composition for suppressing or inhibiting the growth of microorganisms in a food, cosmetic or pharmaceutical product, or home care product.SOLUTION: Provided are compositions comprising or consisting of (a1) an effective amount of 1, 2-heptanediol, (b1) an effective amount of at least one antimicrobial constituent, and (c1) optionally, at least one agent and / or excipient for a foodstuff, cosmetic or pharmaceutical composition, or home care product.SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] The present invention provides an effective amount of an antimicrobial component, as well as an effective amount of 1,2-heptanediol and and / or 2,3-heptanediol, or a specific alkanediol or two The present invention relates to a synergistic combination of a mixture of the above specific alkanediols. Furthermore, the present invention relates to a food, cosmetic or pharmaceutical preparation comprising said composition. Furthermore, the present invention relates to a food, cosmetic or pharmaceutical product, or a home care product. or use of said composition to inhibit or prevent microbial growth in home care products. Additionally, the present invention relates to the use of 1,2-heptaerythritol to enhance the efficacy of antimicrobial components. or a specific alkanediol, or two or more different specific alkanediols Finally, the present invention relates to the use of a mixture of ols in an effective amount. Methods for suppressing or inhibiting the growth of microorganisms in pharmaceutical or home care products Regarding. [Background technology]

[0002] Food, cosmetic or pharmaceutical products, or home care products are ideal for microbial contamination. The medium contains proteins, sugars, vitamins, oils, and water, which are used for the growth of microorganisms. Contains everything you need to make cosmetics, especially those with high moisture content and / or large surfaces. or pharmaceutical preparations, such as emulsions or wet wipes, or Formulations with contaminated natural ingredients are susceptible to microbial growth. The pH level and warm, humid bathroom conditions contribute to an ideal environment for bacteria and mold. Many microorganisms enter the product via the hands and oral cavity. The majority of microorganisms may already be present in the food supply, for example from contaminated raw materials. However, microbial contaminants can cause dangerous infections. In addition, some molds and bacteria may cause allergic reactions and skin irritation. It produces toxins that

[0003] To minimize microbial contamination, preservatives are used. Preservatives kill microorganisms. It is essential for the production of cosmetics because it prevents or inhibits the growth of bacteria. If the product is not soluble in water, this may subsequently cause deterioration of the product, which may lead to the deterioration of the fragrance in cosmetics. Changes in color, discoloration, mold growth, gas formation, emulsion separation, or viscosity changes These can appear as flammable compounds, making the product unacceptable to consumers.

[0004] Preservatives therefore play a vital role in preserving cosmetics from deterioration and in protecting against potentially dangerous microorganisms. However, all of the substances that can be used as preservatives are Not all are harmless to consumers. Parabens, for example, have hormonal effects; benzoin Acids can cause pseudo-allergic reactions. German cosmetic regulations state that the It lists all permitted preservatives.

[0005] Additionally, there are several natural materials that contain substances that are said to have antimicrobial effects. These include, for example, propolis, cinnamon bark, clove oil, allspice oil, nut oil, These include medicinal herbs, ylang-ylang, rose oil, and thyme. However, these substances are not used in cosmetic products. Its use as a preservative in industry has not been adequately researched.

[0006] At present, there are no legally binding limits for pathogen content in cosmetics. Scientific Committee on Consumer Safety According to the recommendations of the European Commission, cosmetic products should Over 100 or 1,000 colony-forming units per gram, depending on the type of product It should not contain certain pathogens, such as Staphylococcus or E. coli becomes completely undetectable.

[0007] Therefore, in the cosmetics, pharmaceutical or home care product industries, as well as in the food industry, There is a continuing need for agents with antimicrobial properties for the protection of ingredients.

[0008] While it is true that a large number of antimicrobially active compounds are already in use in the art, , so that targeted specific treatments can be performed and / or side effects can be reduced However, in this situation, the antimicrobial activity, especially the antiseptic activity, is still required. When investigating alternative agents that have Substances used in the cosmetics, pharmaceutical and / or food sectors Toxicologically acceptable, Well tolerated by the skin are stable (especially in conventional cosmetic and / or pharmaceutical formulations), be substantially, preferably completely, odorless; and Inexpensively (i.e., using standard methods and / or starting from standard precursors) It must be possible to prepare it and it must be of natural origin, and It must be taken into account that the development of renewable energy must be based on green synthesis.

[0009] Between the chemical structure of a substance on the one hand, and its biological activity against certain microorganisms (pathogens) on the other hand. The activity and its stability are not explicitly dependent on the ability to achieve one or more of the above properties to a sufficient extent. The search for suitable (active) substances possessing such properties is difficult for those skilled in the art, and furthermore, the possibility of their being affected by the skin is also unclear. There is no predictable relationship between antimicrobial activity, toxicological acceptability, tolerability and substance stability.

[0010] Additionally, the antimicrobial component should have antimicrobial activity properties that meet a variety of criteria. These are: Broad spectrum antimicrobial activity against gram-positive and gram-negative bacteria, yeasts, molds and fungi Equipped with Particularly active against Candida and Aspergillus; and It should be active in different cosmetic or pharmaceutical formulations, especially at different pH values.

[0011] Biocides according to the Biocides Regulation, especially traditional biocides such as formaldehyde donors The addition of preservatives is becoming increasingly undesirable, especially with regard to natural cosmetics.

[0012] Sterilization of formulations is necessary because of the potential for degradation of formulation components during heat treatment and the associated This is less desirable due to the additional processing costs.

[0013] Therefore, it is microbially safe and microbially stable during its shelf life. There is still a continuing need to develop new compositions. The cosmetic or pharmaceutical industry is We are constantly searching for ingredients that can improve the appearance of skin. The overall content of antimicrobial agents in the formulation can be reduced, resulting in higher performance of the antimicrobial agent at the same dose. or vice versa, to achieve the same performance with a lower amount of antimicrobial agent. As a result, there is ongoing interest in improving both the efficacy and range of efficiency of such antimicrobial agents. It exists as such.

[0014] The object of the present invention is therefore to provide, inter alia, a cosmetic or pharmaceutical preparation or a home care a composition that exhibits a synergistic effect against a number of bacteria, yeasts, molds and fungi in the product; and microbial activity or activity in cosmetic or pharmaceutical preparations or home care products. The present invention provides a use thereof in which the growth or development of a plant can be suppressed or inhibited.

[0015] Furthermore, the object of the present invention is to provide a food, cosmetic or pharmaceutical preparation comprising said composition, or is to provide home care products.

[0016] It is a further object of the present invention to provide a substance that can enhance the antimicrobial efficacy of antimicrobial components. To do this.

[0017] Furthermore, the object of the present invention is to provide a method for the preparation of a food, cosmetic or pharmaceutical product or a home care product. The present invention provides a method for controlling or inhibiting the growth of microorganisms.

[0018] The present invention provides an effective amount of 1,2-heptanediol or 2, as defined herein. ,3-heptanediol, or 1,2-heptanediol and 2,3-heptanediol A mixture containing a specific alkanediol, or two or more different specific alkanediols The combination of the candiol mixture and the antimicrobial component can combat a number of microorganisms, e.g., bacteria, The unexpected finding of synergistic antimicrobial efficacy against yeast, mold, and fungi Food, cosmetic or pharmaceutical preparations, or home care products of such compositions The use of the method in the preparation of the microorganisms subsequently results in a stable preparation of the microorganisms, which can be stored. , synergistic antimicrobial efficacy are known to be achieved only with great difficulty. andida species, e.g., Candida albicans and Aspergillus It is also suitable for Aspergillus species, e.g., Aspergillus brasiliensis. It can be done. Summary of the Invention

[0019] To accomplish the above object, the present invention provides, in a first aspect, (a1) an effective amount of 1,2-heptanediol; (b1) an effective amount of at least one antimicrobial component, and (c1) optionally, a small amount for a food, cosmetic or pharmaceutical composition, or a home care product; at least one active substance and / or additive, or (a2) an effective amount of 2,3-heptanediol; (b2) an effective amount of at least one antimicrobial component, and (c2) optionally, a small amount for a food, cosmetic or pharmaceutical composition, or a home care product; at least one active substance and / or additive, or (a3) a mixture comprising effective amounts of 1,2-heptanediol and 2,3-heptanediol thing, (b3) an effective amount of at least one antimicrobial component, and (c3) optionally, a small amount for a food, cosmetic or pharmaceutical composition, or a home care product; A composition comprising or consisting of at least one active substance and / or additive provide.

[0020] In a second aspect, the present invention provides a method for producing a medicament for the treatment of a pulmonary arthritis, comprising: (a) an effective amount of at least one linear alkane having a carbon chain of 5 to 14 carbon atoms; a diol or at least one first linear diol having a carbon chain of 5 to 14 carbon atoms; an alkanediol and a 5 to 14 carbon atom different from the first linear alkanediol; a mixture comprising one or more second linear alkanediols having a carbon chain length of 100 nm, (b) an effective amount of at least one antimicrobial component, and (c) optionally, a small amount for a food, cosmetic or pharmaceutical composition, or home care product; and providing a composition comprising or consisting of at least one active substance and / or additive. To provide.

[0021] In a further aspect, the present invention relates to a food, cosmetic or pharmaceutical product comprising the composition according to the invention. The present invention provides a cosmetic preparation or home care product.

[0022] In a further aspect, the present invention relates to a food, cosmetic or pharmaceutical preparation, or home care Use of the composition according to the invention to suppress or inhibit the growth of microorganisms in a product to provide.

[0023] In yet a further aspect, the present invention provides a method for enhancing the efficacy of an antimicrobial component, comprising: -heptanediol or 2,3-heptanediol, or 1,2-heptanediol a mixture containing 2,3-heptanediol and 2,3-heptanediol, or at least one linear alkane diol, or at least one first linear alkanediol and one or more The present invention provides the use of a mixture comprising a second linear alkanediol of In a final aspect, the present invention relates to a food, cosmetic or pharmaceutical preparation or a home care product. The present invention provides a method for controlling or inhibiting microbial growth in a food product. [Brief explanation of the drawings]

[0024] [Figure 1] 1 is a diagram visualizing the synergistic antimicrobial efficacy of 1,2-heptanediol and 1,2-octanediol against Aspergillus brasiliensis. [Figure 2] 1 is a diagram visualizing the synergistic antimicrobial efficacy of 1,2-heptanediol and 1,2-octanediol against Candida albicans. [Figure 3] 1 is a diagram visualizing the antimicrobial efficacy of 0.2% disodium EDTA against bacteria. [Figure 4] 1 is a diagram visualizing the antimicrobial efficacy of 0.2% 1,2-heptanediol against bacteria. [Figure 5] 1 is a diagram visualizing the synergistic antimicrobial efficacy of 0.1% disodium EDTA and 0.1% 1,2-heptanediol against bacteria. [Figure 6] 1 is a diagram visualizing the synergistic antimicrobial efficacy of 1,2-heptanediol and 2,3-heptanediol against Candida albicans. DETAILED DESCRIPTION OF THE INVENTION

[0025] The present invention is set out in the appended claims, but the invention itself and its preferred embodiments are not to be construed as limiting the scope of the invention. Preferred modifications, other objects and advantages are set forth in the following detailed description taken in conjunction with the accompanying examples and drawings. This is also clear from the

[0026] In a first aspect, the present invention provides a method for producing a cellular membrane comprising: (a1) an effective amount of 1,2-heptanediol; (b1) an effective amount of at least one antimicrobial component, and (c1) optionally, a small amount for a food, cosmetic or pharmaceutical composition, or a home care product; A composition comprising or consisting of at least one active substance and / or additive Regarding.

[0027] Alternatively, in a first aspect, the present invention provides a method for producing a composition comprising: (a2) an effective amount of 2,3-heptanediol; (b2) an effective amount of at least one antimicrobial component, and (c2) optionally, a small amount for a food, cosmetic or pharmaceutical composition, or a home care product; A composition comprising or consisting of at least one active substance and / or additive Regarding.

[0028] In a further alternative, the present invention provides in a first aspect: (a3) a mixture containing effective amounts of 1,2-heptanediol and 2,3-heptanediol thing, (b3) an effective amount of at least one antimicrobial component, and (c3) optionally, a small amount for a food, cosmetic or pharmaceutical composition, or a home care product; A composition comprising or consisting of at least one active substance and / or additive Regarding.

[0029] In a preferred variant of the first aspect of the invention, component (b) is different from component (a). do.

[0030] In a second aspect, the present invention provides a method for producing a medicament for the treatment of a pulmonary arthritis, comprising: (a) an effective amount of at least one linear alkali metal ion having a carbon chain of 5 to 14 carbon atoms; or at least one first diol having a carbon chain of 5 to 14 carbon atoms a linear alkanediol and a first linear alkanediol having a carbon chain of 5 to 14 carbon atoms; a mixture comprising one or more second linear alkanediols different from the alkanediol; , (b) an effective amount of at least one antimicrobial component, and (c) optionally, a small amount for a food, cosmetic or pharmaceutical composition, or home care product; and / or any composition comprising or consisting of at least one active substance and / or additive. do.

[0031] In a preferred variant of the second aspect of the invention, component (b) is different from component (a). do.

[0032] In a more preferred variation of the second aspect, the present invention provides a method for treating a cancer cell comprising: (a') at least one first linear alkyl group having a carbon chain of 5 to 14 carbon atoms; and one or more second phenylalanines having a carbon chain of 5 to 14 carbon atoms. A mixture comprising an effective amount of a first and a second linear alkanediol. The number of carbon atoms in the chains may be the same or different, or a mixture thereof; (b') an effective amount of at least one antimicrobial component, and (c') optionally, a small amount for a food, cosmetic or pharmaceutical composition, or a home care product; A composition comprising or consisting of at least one active substance and / or additive Regarding.

[0033] The term "comprising" means that the named component in the composition is essential, but other Components may be added and still be meant to be encompassed by the present invention.

[0034] The term "consisting of" as used in accordance with the present invention refers to the sum of components (a) to (c). The measurements mean that the total adds up to 100% by weight of the total weight of the composition, and the subject matter is The term "complex" means that the invention is open-ended and may include only those limitations expressly recited.

[0035] Whenever "including" is mentioned, the meaning is "including" unless the context dictates otherwise. It can be "comprises" or "consists of" and is intended to cover both meanings as alternatives. do.

[0036] The term "at least one..." means that the composition according to the present invention is One, two, three, four, five, six, or even more variations of each component This means that the compound may include a mixture of the compounds.

[0037] The term "optionally" means that the subsequently listed component may be present in the composition, but The description does not necessarily include variations in which the compound is present, or in which the compound is present. This means that the term includes variations that are not included in the original text.

[0038] The term "synergy" refers to the interaction of two different chemical or biological structures. If there is an overall cumulative effect that exceeds the sum of any of the individual effects, In the present invention, synergistic effect relates to a synergistic antimicrobial effect.

[0039] The antimicrobial effect associated with the present invention is characterized by the reduction or even inhibition of microbial growth, This means that the number of living microorganisms is reduced.

[0040] Alkanediols are a class of organic compounds that belong to the glycol, or alcohol, family. In the glycol molecule, two hydroxyl (-OH) groups are are attached to different carbon atoms.

[0041] Component (a) in the composition according to the first aspect of the present invention is 1,2-heptanediol. heptanediol (a1) or 2,3-heptanediol (a2), or both heptanediols , i.e., a mixture containing 2,3-heptanediol in addition to 1,2-heptanediol ( a3).

[0042] 1,2-Heptanediol belongs to the class of alkanediols and has the general formula: [ka] It is a linear alkanediol having a carbon chain with 7 carbon atoms, The two functional OH groups of the alkanediol are in the alpha and beta positions. It is chemically bonded to the C1 and C2 carbon atoms in the chain.

[0043] 2,3-Heptanediol belongs to the class of alkanediols and has the general formula: [ka] It is a linear alkanediol. It has a carbon chain with seven carbon atoms and is The two functional OH groups of the diol are in the beta and gamma positions, and in the alkanediol chain It is chemically bonded to the C2 and C3 carbon atoms.

[0044] Linear 1,2-alkanediols have been used as multifunctional active substances for over 15 years. Chain 1,2-alkanediols are amphiphilic compounds and therefore 1,2-pentanediols ol and 1,2-hexanediol, are soluble in both water and cosmetic oils. In contrast, 1,2-octanediol is a solid and has a viscosity of ≥ 0.05 in oily solutions as well as in water. At 5%, 1,2-decanediol tends to precipitate or recrystallize. , which are soluble only in cosmetic oils. Apart from moisturizing, some 1,2-alkanediols also Used as a viscosity modifier.

[0045] Component (a) in the composition according to the second aspect of the present invention is, in the first alternative, and at least one linear alkanediol having a carbon chain of 1 to 14 carbon atoms.

[0046] Further, in a second alternative of this second aspect, component (a) is a second linear alkane A first linear alkanediol, preferably having 5 to 14 carbon atoms, in combination with a diol. at least one first linear alkanediol having a carbon chain length of 5 to 14 and at least one second linear alkanediol having a carbon chain of 10 carbon atoms. Thus, the present invention provides a method for preparing a first and second alkanediol as described herein. It is also accompanied by a mixture of

[0047] The first linear alkanediol of the present invention is the first option of the second aspect described below. The linear alkanediols may be selected from the same list and types of compounds as those described above, Generally, linear alkanediols are referred to, which are first linear alkanediols. In a mixture of first and second linear alkanediols, these may be specifically different. When the two alkanediol structures are combined, the specific terms "first" and "second" refer to the two alkanediol structures. Used to distinguish between components.

[0048] As used in this document, "at least one linear alkanediol" or "at least and a first linear alkanediol" means that the composition is a linear alkanediol having 5 to 14 carbon atoms. It may contain one linear alkanediol having a carbon chain of 100 atoms, or 5 to 14 or one first linear alkanediol having a carbon chain of carbon atoms The alkanediols may contain more than one linear alkanediol, or may have a carbon chain of 5 to 14 carbon atoms. More than one first linear alkanediol, i.e., two, three, four or more different A linear alkanediol or a first linear alkanediol having a carbon chain of 5 to 14 carbon atoms This means that it may contain alkanediols.

[0049] The linear alkanediol or first linear alkanediol has two different Two OH functional groups attached to the carbon atom and five to four carbon atoms connected to each other by a single covalent bond. It consists of a chain of 14 carbon atoms.

[0050] In the composition according to the second aspect of the present invention, at least one linear alkanediol, or at least one first linear alkane having a carbon chain of 5 to 14 carbon atoms The diol is preferably pentanediol, hexanediol, heptanediol, octanediol, Tandanediol, nonanediol, decanediol, undecanediol, dodecanediol tridecanediol, tetradecanediol, and mixtures thereof. It is selected.

[0051] In a preferred variant, at least one linear alkanediol or at least one The first linear alkanediol is pentanediol, hexanediol, heptanediol, , octanediol, nonanediol, decanediol, undecanediol, dodecanediol The diol is selected from the group consisting of decanediol and tridecanediol.

[0052] In a more preferred variant, at least one linear alkanediol, or at least one The first linear alkanediol is octanediol.

[0053] In an even more preferred variant, at least one linear alkanediol or at least The first linear alkanediol is an alkanediol having 5 to 13 odd carbon atoms. Diols, namely pentanediol, heptanediol, nonanediol, undecanediol The diol is selected from the group consisting of decanediol, tridecanediol, and mixtures thereof.

[0054] In an even more preferred variant, at least one linear alkanediol, or at least The first linear alkanediol may have an odd number of carbon atoms, such as 7, 9, 11, and 13. Alkanediols having the formula: heptanediol, nonanediol, undecanediol and tridecanediol, or 9 and 11 odd-chain alkyl esters selected from the group consisting of decanediol and tridecanediol. Alkanediols having several carbon atoms, namely nonanediol and undecanediol or an alkyl group having an odd number of carbon atoms between 9 and 13. and benzodiols, i.e., nonanediol and tridecanediol. , or alkanediols with odd numbers of carbon atoms, i.e., 11 and 13, It is selected from the group consisting of decanediol and tridecanediol.

[0055] In an even more preferred variant, at least one linear alkanediol, or at least The first linear alkanediol is pentanediol, hexanediol, heptanediol, The diol is tanediol, octanediol or nonanediol.

[0056] In the most preferred variant, at least one linear alkanediol, or at least The linear alkanediol in 1 is heptanediol or nonanediol.

[0057] In the alternative, the composition according to the second aspect of the invention comprises a carbon atom of 5 to 14 carbon atoms. at least one first linear alkanediol having a chain length of 5 to 14 carbon atoms; one or more second linear alkanediols different from the first linear alkanediols, each having a carbon chain of 100 atoms; The present invention also includes mixtures containing linear alkanediols of the formula:

[0058] This means that the alkanediol mixture contains at least one alkanediol having a carbon chain length of 5 to 14 carbon atoms. at least one first linear alkanediol, and a carbon chain of 5 to 14 carbon atoms one or more, i.e., two, three, four or more, second linear alkanediols In this option, the first linear alkanediol is a mixture containing for linear alkanediols in general, and for the first option of the second embodiment in particular The alkanediol may be any of the alkanediols described herein.

[0059] For example, the mixture may comprise one first linear alkanediol and one, two, three or more or the mixture may comprise two first linear alkanediols. The alkanediol may comprise one, two, three or more second linear alkanediols, etc. provided that in each mixture, the first linear alkanediol and the second linear alkanediol Provided that the diols are different from each other.

[0060] The phrase "different from each other" refers to the first linear alkanediol and the second linear alkanediol in the mixture. The two linear alkanediols are classified according to the length of the carbon chain, i.e., the number of carbon atoms, and or differing in terms of their structural isomerism or in terms of their stereoisomerism.

[0061] Similarly, the first linear alkanediol and the second linear alkanediol in the mixture For example, the number of carbon atoms in the first linear alkanediol and the second linear alkanediol may be the same. The linear alkanediol has a carbon chain of seven carbon atoms, whereas the first linear alkanediol The alkyl and the second linear alkanediol may be substituted with respect to their structural isomerism or with respect to their stereoisomerism. differs in terms of

[0062] The second linear alkanediol is preferably attached to two different carbon atoms in the chain. Two OH functional groups and 5 to 14 carbon atoms connected together by a single covalent bond It consists of a chain of

[0063] In the composition according to the second aspect of the invention, The at least one second linear alkanediol is selected from the group consisting of pentanediol, hexanediol, and the like. Heptanediol, Octanediol, Nonanediol, Decanediol, Undecanediol The compound consists of decanediol, dodecanediol, tridecanediol and tetradecanediol. The compound is selected from the group consisting of:

[0064] In a preferred variant, the at least one second linear alkanediol is a pentanediol. hexanediol, heptanediol, octanediol, nonanediol, decane The group consisting of diols, undecanediols, dodecanediols and tridecanediols Both the first and second alkanediols are selected from, for example, heptanediol If the second linear alkanediol is heptanediol, then the first linear alkanediol is It is a structural isomer or stereoisomer different from candiol.

[0065] In a more preferred variation, the at least one second linear alkanediol is a pentanediol. diol, hexanediol, heptanediol, octanediol and nonanediol , most preferably selected from the group consisting of octanediol and nonanediol.

[0066] The term "alkanediol" is used within the context of the present invention to include its structural isomers or This includes positional isomers. Structural isomers are compounds with the same molecular formula and different connectivity. A specific form of structural isomerism, positional isomers, differ only in the position of functional groups on the parent structure. In this case, the positions of the two alcohol groups are It is the position of the functional base.

[0067] Depending on the number of carbon atoms in the carbon chain of the alkanediol, various positional variations of the alkanediol can be observed. Structural isomer:(x,x+1)Structural isomer;(x,x+2)Structural isomer;(x,x+3)Structural isomer etc., and when the alcohol functional group is at the end of the carbon chain, alpha-omega structural isomerism occurs. x is the chemical bond between the OH groups of the alkanediol in the alkanediol chain. For example, if x is 1, the O of two alkanediols H groups are chemically bonded to the C1 and C2 carbon atoms in the alkanediol chain; When x is 2, the OH groups of the two alkanediols are bonded to the C It is chemically bonded to the C2 and C3 carbon atoms.

[0068] In the (x,x+1) structural isomer, the two OH functional groups are located on two different adjacent sites in the chain. In the (x,x+2) structural isomer, two OH functional groups are attached to the carbon atom. A group is a carbon atom that is attached to two different carbon atoms in a chain if the two carbon atoms are separated by one C atom. In the (x,x+3) structural isomer, the two OH functional groups are attached to two carbon atoms. If an atom is separated by two C atoms, it will be attached to two different carbon atoms in the chain. In the alpha, omega structural isomer, the two functional groups are located at the first C atom and at the terminal It is attached to a C atom.

[0069] In a preferred variant of the composition according to the second aspect of the invention, the carbon The linear alkanediol having a chain is preferably a 1,2-diol, a 2,3-diol, 3,4-diols, 4,5-diols, further (x,x+1) diols and their mixtures and preferably an alkyl group selected from the group consisting of vicinal (x, x+1) diols. It is a fa, beta 1,2 structural isomer.

[0070] In a preferred variant of the composition according to the second aspect of the invention, a first linear alkanediol, and / or a second linear alkanediol having a carbon chain of 5 to 14 carbon atoms , 1,2-diols, 2,3-diols, 3,4-diols, 4,5-diols, and more Vicinal (x, x+1) diols selected from the group consisting of (x, x+1) diols and mixtures thereof , x+1) diol, preferably the alpha, beta 1,2 structural isomer.

[0071] In a further preferred variant of the composition according to the second aspect of the invention, the composition comprises 5 to 14 carbon atoms. The linear alkanediols having a long carbon chain are preferably 1,3-diols, 2,4- diols, 3,5-diols, further (x,x+2) diols and mixtures thereof and preferably alpha, gal, or alpha-gal. It is a 1,3 structural isomer of quinone.

[0072] In a preferred variant of the composition according to the second aspect of the invention, a first linear alkanediol, and / or a second linear alkanediol having a carbon chain of 5 to 14 carbon atoms , 1,3-diols, 2,4-diols, 3,5-diols, 4,6-diols, and more non-vicinity (x, x+2) diols selected from the group consisting of (x, x+2) diols and mixtures thereof x+2) diols, preferably alpha, gamma 1,3-structural isomers.

[0073] In a further preferred variant of the composition according to the second aspect of the invention, the composition comprises 5 to 14 carbon atoms. The linear alkanediol having a long carbon chain is preferably a 1,4 diol, a 2,5 diol. a non-(x,x+3)diol selected from the group consisting of: a diol, a further (x,x+3)diol, and mixtures thereof; It is a vicinal (x,x+3) diol, preferably an alpha, delta 1,4 structural isomer. do.

[0074] In a preferred variant of the composition according to the second aspect of the invention, a first linear alkanediol, and / or a second linear alkanediol having a carbon chain of 5 to 14 carbon atoms , 1,4 diols, 2,5 diols, further (x,x+3) diols and mixtures thereof The non-vicinity (x, x+3) diol is selected from the group consisting of alpha- and alpha-diols. It is a α, delta 1,4 structural isomer.

[0075] In a preferred variant of the composition according to the second aspect of the invention, a linear alkanediol, or The first linear alkanediol and / or the second linear alkanediol are preferably is an alpha, omega alkanediol, more preferably 1,7-heptanediol or is 1,8-octanediol.

[0076] Vicinal (x,x+1) diols according to the present invention are most preferred, e.g. alpha, beta Or beta, gamma or gamma, delta.

[0077] In a further preferred variant of the composition according to the second aspect of the invention, a linear alkanediol, In particular, the first linear alkanediol and / or the second linear alkanediol may be 1, 2-alkanediols, 2,3-alkanediols, 3,4-alkanediols, or Mixtures thereof, with 2,3-alkanediols being more preferred.

[0078] Linear alkanediols, particularly first linear alkanediols having a carbon chain of 5 to 14 carbon atoms. and / or a second linear alkyl having a carbon chain of 5 to 14 carbon atoms. The 1,2-alkanediol of the alkanediol is preferably represented by the following formula: could be: 1,2-Pentanediol [ka] 1,2-Hexanediol [ka] 1,2-heptanediol [ka] 1,2-octanediol [ka] 1,2-Nonanediol [ka] 1,2-Decanediol [ka] 1,2-Undecanediol [ka] 1,2-Dodecanediol [ka] 1,2-Tridecanediol [ka] 1,2-Tetradecanediol [ka]

[0079] The linear alkanediols of the present invention, in particular the first alkanediols having a carbon chain of 5 to 14 carbon atoms, a linear alkanediol, and / or a second alkanediol having a carbon chain of 5 to 14 carbon atoms The linear alkanediol 2,3-alkanediol is preferably represented by the formula: It can be: 2,3-Pentanediol [ka] 2,3-Hexanediol [ka] 2,3-heptanediol [ka] 2,3-octanediol [ka] 2,3-Nonanediol [ka] 2,3-Decanediol [ka] 2,3-Undecanediol [ka] 2,3-Dodecanediol [ka] 2,3-Tridecanediol [ka] 2,3-Tetradecanediol [ka]

[0080] A first linear alkanediol, preferably having a carbon chain of 5 to 14 carbon atoms. alkanediols, and / or second linear alkyl alkanediols having a carbon chain of 5 to 14 carbon atoms. The 3,4-alkanediol of the alkanediol is preferably represented by the following formula: It can be: 3,4-Hexanediol [ka] 3,4-heptanediol [ka] 3,4-octanediol [ka] 3,4-Nonanediol [ka] 3,4-Decanediol [ka] 3,4-Undecanediol [ka] 3,4-Dodecanediol [ka] 3,4-Tridecanediol [ka] 3,4-Tetradecanediol [ka]

[0081] In a preferred variant, the composition according to the second aspect of the invention comprises a carbon atom having from 5 to 14 carbon atoms. at least one first linear alkanediol having a base chain of 5 to 14 carbon atoms; and one or more second linear alkanediols having a carbon chain of 10 atoms, and the second alkanediol may have the same or different number of carbon atoms, including mixtures thereof. .

[0082] When both the first and second alkanediols have the same number of carbon atoms, Such combinations of alkanediols are referred to herein as "homoalkanediol mixtures." For example, a first linear alkanediol and a second linear alkanediol are also called "homocombinations." The linear alkanediol has a carbon chain of 7 carbon atoms, but the first linear alkanediol The alkanediol and the second linear alkanediol are not related in terms of their structural isomerism or in terms of their stereoisomerism. differ regarding gender.

[0083] When the first and second alkanediols have different numbers of carbon atoms, such A combination of alkanediols is referred to herein as a "heteroalkanediol mixture" or "heteroalkanediol mixture." For example, the first linear alkanediol has seven carbon atoms. The first linear alkanediol has a carbon chain of 10 carbon atoms, and the second linear alkanediol has a carbon chain of 8 carbon atoms. However, in addition, a first linear alkanediol and a second linear alkanediol are The molecules may differ in terms of their structural isomerism or in terms of their stereoisomerism.

[0084] In a preferred variant of the composition according to the second aspect of the invention, the composition comprises a linear alkanediol or The linear alkanediol in 1 is: 1,2-pentanediol, 2,3-pentanediol, 3,4-pentanediol, 1,2-hexanediol, 2,3-hexanediol, 3,4-hexanediol, 1,2-heptanediol, 2,3-heptanediol, 3,4-heptanediol, 1,2-octanediol, 2,3-octanediol, 3,4-octanediol, 1,2-nonanediol, 2,3-nonanediol, 3,4-nonanediol, 1,2-decanediol, 2,3-decanediol, 3,4-decanediol, 1,2-Undecanediol, 2,3-Undecanediol, 3,4-Undecanediol Lu, 1,2-dodecanediol, 2,3-dodecanediol, 3,4-dodecanediol, 1,2-Tridecanediol, 2,3-Tridecanediol, 3,4-Tridecanediol and mixtures thereof.

[0085] The linear alkanediol or the first linear alkanediol, Beta structural isomers: 1,2-pentanediol, 2,3-pentanediol, 1,2-hexanediol Hexanediol, 2,3-hexanediol, 1,2-heptanediol, 2,3-heptanediol Tandiol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol ol, 2,3-undecanediol, 2,3-dodecanediol or 2,3-tridecanediol Alkanediols are preferred. The alkanediols are liquids with a purity of 90 to 99%. .

[0086] Of the liquid alkanediols mentioned above, 1,2-pentanediol, 2,3-pentanediol, 1,2-Hexanediol, 2,3-Hexanediol, 1,2-Heptanediol 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol Or a mixture of the liquid alkanediols is particularly preferred. It can be more easily incorporated into the product or final product.

[0087] In a more preferred variant, at least one linear alkanediol, or at least one The first linear alkanediol is a 1,2-alkanediol having an odd number of carbon atoms from 5 to 13. Lactonediols, namely 1,2-pentanediol, 1,2-heptanediol, 1, 2-nonanediol, 1,2-undecanediol, 1,2-tridecanediol and The compound is selected from the group consisting of a mixture thereof.

[0088] In a more preferred variation, the linear alkanediol or first linear alkanediol is 1,2-alkanediols with odd numbers of carbon atoms, i.e., 7, 9, 11 and 13 1,2-heptanediol, 1,2-nonanediol, 1,2-undecanediol or 1,2-tridecanediol, or 9 and 11 odd 1,2-alkanediols having several carbon atoms, namely 1,2-nonanediol and and 1,2-undecanediol, or an odd number between 9 and 13 1,2-alkanediols having carbon atoms of 1,2-nonanediol and 1,2-tridecanediol, or an odd number between 11 and 13 1,2-alkanediols having carbon atoms, namely 1,2-undecanediol and and 1,2-tridecanediol.

[0089] In a more preferred variant, at least one linear alkanediol, or at least one The first linear alkanediol is a 2,3-alkanediol having an odd number of carbon atoms from 5 to 13. Lactonediols, namely 2,3-pentanediol, 2,3-heptanediol, 2, 3-nonanediol, 2,3-undecanediol, 2,3-tridecanediol and The compound is selected from the group consisting of a mixture thereof.

[0090] In an even more preferred variation, the linear alkanediol or first linear alkanediol 2,3-alkanediols with odd numbers of carbon atoms: 7, 9, 11 and 13; Namely, 2,3-heptanediol, 2,3-nonanediol, 2,3-undecanediol or 9 and 11 2,3-alkanediols with an odd number of carbon atoms, i.e., 2,3-nonanediols and 2,3-undecanediol, or 9 and 13 2,3-alkanediols with an odd number of carbon atoms, i.e., 2,3-nonanediol and 2,3-tridecanediol, or 11 and 13 2,3-alkanediols with an odd number of carbon atoms, i.e., 2,3-undecanediols and 2,3-tridecanediol.

[0091] In a further preferred variant of the composition according to the second aspect of the invention, a linear alkanediol Or the first linear alkanediol is: 1,2-pentanediol, 2,3-pentanediol, 3,4-pentanediol, 1,2-hexanediol, 2,3-hexanediol, 3,4-hexanediol, 1,2-heptanediol, 2,3-heptanediol, 3,4-heptanediol, 1,2-octanediol, 2,3-octanediol, 3,4-octanediol, 1,2-nonanediol, 2,3-nonanediol, 3,4-nonanediol, and the like The compound is selected from the group consisting of:

[0092] More preferably, in the composition according to the second aspect of the present invention, the linear alkanediol or The first linear alkanediol is 1,2-pentanediol, 2,3-pentanediol, 3,4-pentanediol, 3,4-pentanediol, and mixtures thereof; 1,2-Hexanediol, 1,2-Heptanediol, 2,3-Heptanediol, 3 , 4-heptanediol, and mixtures thereof. The cyclic alkanediol or the first linear alkanediol is preferably 1,2-octaalkanediol. Octanediol, 2,3-octanediol, 3,4-octanediol, and mixtures thereof The compound may also be selected from the group consisting of:

[0093] In the composition according to the second aspect of the present invention, a linear alkanediol is even more preferred. Or the first linear alkanediol is 1,2-heptanediol, 2,3-heptanediol alpha, beta or beta, gamma diols as diols or their mixtures However, the linear alkanediol or the first linear alkanediol is preferably 1,2-octanediol, 2,3-octanediol or a mixture thereof It can also be beta- or gamma-sulfadiol. 1,2-heptanediol and a mixture containing 1,2-octanediol, or 1,2-heptanediol and A mixture of 2,3-octanediol or 1,2-octanediol and 2,3-octanediol Mixtures of butanediols are also contemplated.

[0094] Most preferably, the linear alkanediol or first linear alkanediol is a 1,2- Heptanediol or 1,2-octanediol.

[0095] Also, in a further preferred variant of the composition according to the second aspect of the invention, a linear alkane The diol or first linear alkanediol is: 1,2-nonanediol, 2,3-nonanediol, 3,4-nonanediol, 1,2-decanediol, 2,3-decanediol, 3,4-decanediol, 1,2-Undecanediol, 2,3-Undecanediol, 3,4-Undecanediol and mixtures thereof.

[0096] More preferably, in the composition according to the second aspect of the present invention, the linear alkanediol or The first linear alkanediol is 1,2-nonanediol, 2,3-nonanediol, 3,4-nonanediol and mixtures thereof, or 1,2-decanediol, 2,3-decanediol, 3,4-decanediol and It may also be selected from the group consisting of mixtures thereof, or preferably 1,2-undecane Diols, 2,3-undecanediol, 3,4-undecanediol, and their It may also be selected from the group consisting of mixtures.

[0097] Even more preferred linear alkanediols in the composition according to the second aspect of the present invention Alternatively, the first linear alkanediol may be 1,2-nonanediol, 2,3-nonanediol, or alpha, beta or beta, gamma diol, or mixtures thereof. However, the linear alkanediol or the first linear alkanediol is preferably 1 ,2-decanediol, 2,3-decanediol, or mixtures thereof.

[0098] Furthermore, the linear alkanediol or the first linear alkanediol is preferably 1, 2-undecanediol, 2,3-undecanediol, or a mixture thereof 1,2-nonanediol and / or 2,3-decanediol and / or or a mixture of 2,3-undecanediol, or 1,2-decanediol and / or is a mixture of 2,3-nonanediol and / or 2,3-undecanediol, is 1,2-undecanediol and / or 2,3-nonanediol and 2,3- Mixtures of decanediols are also contemplated.

[0099] In a preferred variant of the composition according to the second aspect of the invention, the second linear alkanediol is : 1,2-pentanediol, 2,3-pentanediol, 3,4-pentanediol, 1,2-hexanediol, 2,3-hexanediol, 3,4-hexanediol, 1,2-heptanediol, 2,3-heptanediol, 3,4-heptanediol, 1,2-octanediol, 2,3-octanediol, 3,4-octanediol, 1,2-nonanediol, 2,3-nonanediol, 3,4-nonanediol, 1,2-decanediol, 2,3-decanediol, 3,4-decanediol, 1,2-Undecanediol, 2,3-Undecanediol, 3,4-Undecanediol Lu, 1,2-dodecanediol, 2,3-dodecanediol, 3,4-dodecanediol, 1,2-Tridecanediol, 2,3-Tridecanediol, 3,4-Tridecanediol and mixtures thereof.

[0100] Among the second alkanediols mentioned above, the following (x, x+1) structural isomers: 1,2-pentaalkanediol 2,3-pentanediol, 1,2-hexanediol, 2,3-hexanediol Sandiol, 1,2-heptanediol, 2,3-heptanediol, 2,3-octanediol 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol 2,3-dodecanediol, or 2,3-tridecanediol are particularly preferred. The alkanediol is a liquid with a purity of 90 to 99%.

[0101] Of the liquid alkanediols mentioned above, 1,2-pentanediol, 2,3-pentanediol, 1,2-Hexanediol, 2,3-Hexanediol, 1,2-Heptanediol 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol or mixtures of the liquid alkanediols are particularly preferred. It can be more easily incorporated into semi-finished or finished products.

[0102] In a more preferred variation, the second linear alkanediol contains 5 to 13 odd carbon atoms. 1,2-alkanediols having alkyl groups, namely 1,2-pentanediol, 1,2-hexanediol, Butanediol, 1,2-nonanediol, 1,2-undecanediol, 1,2-triol decanediol and mixtures thereof.

[0103] In a more preferred variation, the second linear alkanediol is selected from the group consisting of 7, 9, 11 and 13 alkyl groups. 1,2-alkanediols with an odd number of carbon atoms, i.e., 1,2-heptanediol , 1,2-nonanediol, 1,2-undecanediol and 1,2-tridecanedio or 1,2-olefins having an odd number of carbon atoms, 9 and 11 -Alkanediols, namely 1,2-nonanediol and 1,2-undecanediol or 1,2-diols having an odd number of carbon atoms between 9 and 13 -Alkanediols, namely 1,2-nonanediol and 1,2-tridecanediols or 1,2-diols having an odd number of carbon atoms, 11 and 13; -Alkanediols, namely 1,2-undecanediol and 1,2-tridecanediol The compound is selected from the group consisting of ol.

[0104] In a more preferred variation, the second linear alkanediol contains 5 to 13 odd carbon atoms. 2,3-alkanediols having alkyl groups, namely 2,3-pentanediol, 2,3-hexanediol, Butanediol, 2,3-nonanediol, 2,3-undecanediol, 2,3-triol decanediol and mixtures thereof.

[0105] In an even more preferred variation, the second linear alkanediol is selected from the group consisting of 7, 9, 11, and 1 2,3-alkanediols with three odd carbon atoms, i.e., 2,3-heptanediols ol, 2,3-nonanediol, 2,3-undecanediol and 2,3-trideca or having an odd number of carbon atoms between 9 and 11 2,3-alkanediols, namely 2,3-nonanediol and 2,3-undecane diols having an odd number of carbon atoms between 9 and 13; ,3-alkanediols, namely 2,3-nonanediol and 2,3-tridecanediol or 2-carbon alkyl groups having an odd number of carbon atoms, 11 and 13; ,3-alkanediols, namely 2,3-undecanediol and 2,3-trideca The compound is selected from the group consisting of benzols.

[0106] In a more preferred variant of the composition according to the second aspect of the invention, the second linear alkanediol The rule is: 1,2-pentanediol, 2,3-pentanediol, 3,4-pentanediol, 1,2-hexanediol, 2,3-hexanediol, 3,4-hexanediol, 1,2-heptanediol, 2,3-heptanediol, 3,4-heptanediol, 1,2-octanediol, 2,3-octanediol, 3,4-octanediol, 1,2-nonanediol, 2,3-nonanediol, 3,4-nonanediol, and the like The compound is selected from the group consisting of:

[0107] More preferably, in the composition according to the second aspect of the present invention, the second linear alkanediol The alcohols are 1,2-pentanediol, 2,3-pentanediol, and 3,4-pentanediol. However, the second linear alkanedioic acid is selected from the group consisting of alkanediol, ... The alcohol is preferably 1,2-hexanediol, 2,3-hexanediol, 3,4-hexanediol. and mixtures thereof. are 1,2-heptanediol, 2,3-heptanediol, 3,4-heptanediol, and mixtures thereof.

[0108] Even more preferred in the composition according to the second aspect of the present invention is a second linear alkanediol. The alcohol is 1,2-pentanediol, 2,3-pentanediol, or a mixture thereof. However, the second linear alfa The hexanediol is preferably 1,2-hexanediol or 2,3-hexanediol. It can also be 1,2-pentanediol and 2,3-hexanediol, or a mixture thereof. A mixture of 2,3-pentanediol and 1,2-hexanediol Mixtures containing alcohol are also contemplated.

[0109] Most preferably, the second linear alkanediol is 1,2-pentanediol or 2 ,3-pentanediol, or 1,2-hexanediol or 2,3-hexanediol ol, or 1,2-heptanediol or 2,3-heptanediol, or 2 ,3-octanediol, or 2,3-nonanediol.

[0110] In a particularly preferred variant, at least one first linear alkanediol and one or more In accordance with a second aspect of the present invention, the linear alkanediol may comprise a mixture or combination of two or more second linear alkanediols. The composition according to the present invention comprises any one of the following mixtures / combinations: mixtures containing 1,2-pentanediol and 2,3-pentanediol, mixtures containing 1,2-hexanediol and 2,3-hexanediol, mixtures containing 1,2-heptanediol and 2,3-heptanediol, mixtures containing 1,2-octanediol and 2,3-octanediol, mixtures containing 1,2-nonanediol and 2,3-nonanediol, mixtures containing 1,2-decanediol and 2,3-decanediol, mixtures containing 1,2-undecanediol and 2,3-undecanediol, a mixture containing 1,2-dodecanediol and 2,3-dodecanediol, or Mixtures containing 1,2-tridecanediol and 2,3-tridecanediol.

[0111] The homoalkanediol mixture comprises a first linear alkanediol and a second linear alkanediol. The alkanediols have the same number of carbon atoms.

[0112] Particularly advantageous are 2,3-heptanediol and / or 3,4-heptanediol. combinations including 1,2-heptanediol in combination with 2,3-octanediol; 1,2-octanedioic acid in combination with octanediol and / or 3,4-octanediol It is a mixture containing ethanol.

[0113] 1,2-Alkanediols and 2,3-Alkanediols with the same number of carbon atoms The homoalkanediol mixture according to the second aspect of the present invention, which contains When used in combination with other ingredients, the following examples demonstrate that the preservative efficacy test (PET) As demonstrated, a wide range of microbial characterized by synergistic antimicrobial efficacy against bacteria, yeasts and fungi / molds Surprisingly, any synergistic antimicrobial effects are met with great difficulty. Candida species known to be resistant to microbial growth, such as Candida albicans and Aspergillus species, gillus, e.g., Aspergillus brasiliensis, can.

[0114] The synergistic antimicrobial effect or action may be achieved by the use of 1,2-pentanone in combination with an antimicrobial component. It is found in homomixtures with hexanediol and 2,3-pentanediol.

[0115] The synergistic antimicrobial effect is due to the use of 1,2-hexanediol in combination with the antimicrobial component. It is also observed in homomixtures containing 2,3-hexanediol and 2,3-hexanediol.

[0116] 1,2-heptanediol and 2,3-heptanediol in combination with antimicrobial components Homomixtures containing ethanol are particularly beneficial as they have specific and significant synergistic antimicrobial effects. do.

[0117] 1,2-octanediol and 2,3-octanediol in combination with antimicrobial components Alkanediol mixtures containing 1,2-hydroxybenzoates or 1,2-hydroxybenzoates in combination with antimicrobial components Alkanediol mixtures containing 2,3-nonanediol and 2,3-nonanediol are particularly It is advantageous.

[0118] Also, alkanediols including 1,2-decanediol and 2,3-decanediol Mixtures or containing 1,2-undecanediol and 2,3-undecanediol Alkanediol mixtures, when used in combination with different antimicrobial agents, have been shown to be effective against microbial infections. This synergistically reduces the load.

[0119] The synergistic effect was observed when 1,2-dodecanediol and 2,3 -Alkanediol mixture containing dodecanediol, or 1,2-tridecanediol and alkanediol mixtures containing 2,3-tridecanediol.

[0120] The previously mentioned alkanediols, including 1,2-alkanediols and the corresponding 2,3-alkanediols, The homoalkanediol mixtures are used in combination with antimicrobial components. When used in combination with It acts on.

[0121] The previously mentioned synergistically enhanced antimicrobial effect is due to the combination of 1,2-nonanediol and Homomixtures containing 2,3-nonanediol or 1,2-undecanediol and 2 In homomixtures containing 1,3-undecanediol, the corresponding individual 1,2-alkanediols This is particularly evident in comparison with alkanediol or 2,3-alkanediol substances.

[0122] 1,2-alkanediols and the corresponding 2,3-alkanediols in combination with antimicrobial components The above-listed alkalis, including 2,3-alkandeiol, The use of the benzodiol mixture makes it possible to The growth of microorganisms in care products can be significantly inhibited, thus reducing the risk of infection in such formulations. The microbial load may be reduced.

[0123] of a mixture containing a 1,2-alkanediol and the corresponding 2,3-alkanediol, The antimicrobial efficacy described above makes it possible to use in foods, cosmetic or pharmaceutical compositions, The microbial load in home care products can be significantly reduced.

[0124] Therefore, the storage stability of such formulations can be significantly improved, and thus the shelf life. Furthermore, the risk of deterioration during use by the individual user is significantly reduced. .

[0125] Furthermore, the corresponding liquid 2,3-alkanediols can be easily converted into solid 1,2-alkanes, even in small amounts. Diols, solid 1,2-alkanediols, such as 1,2-octanediol, 1,2- It can be dissolved by mixing with nonanediol, etc., to obtain a liquid alkanediol mixture. 2,3-alkanediols act as solvents for solid 1,2-alkanediols. Such a liquid mixture functions primarily to dissolve the solid 1,2-alkanediol in the mixture. Secondly, the availability of solid 1,2-alkanediols as semi-finished or This has the benefit of facilitating incorporation into the final product. When fat-soluble 1,2-alkanediols with carbon chains are used alone, they migrate into the oil phase. This is particularly advantageous for emulsions that tend to be smeared. This causes the 1,2-alkanediols to remain in the aqueous phase where microbial contamination usually occurs. is particularly beneficial for the development of the antimicrobial effect of 1,2-alkanediols in the aqueous phase.

[0126] of solid 1,2-octanediol in liquid 2,3-octanediol or liquid 2 of solid 1,2-nonanediol in 2,3-undecanediol or in liquid 2,3-undecanediol A solution of solid 1,2-undecanediol in 1,2-undecanediol provides a strong antimicrobial 1, 2-octanediol, 1,2-nonanediol or 1,2-undecanediol substances The availability of the end use may also be improved.

[0127] Furthermore, the above compounds containing 1,2-alkanediols and the corresponding 2,3-alkanediols The alkanediol mixture allows for the low-temperature preparation of cosmetic or pharmaceutical formulations, i.e. Heating during preparation is not necessary.

[0128] Therefore, 1,2-alkanediols and the respective 2,3-alkanediols The above-mentioned properties of the described alkanediol mixture, including the It can be improved.

[0129] Thus, the active antimicrobial mixture can be used in formulations while maintaining antimicrobial efficacy. When combined to improve workability, a good balance can be achieved. The combination of 1,2-alkanediols and the corresponding 2,3-alkanediols is This balance is greater than that of the alkanediol or 2,3-alkanediol substances alone. This solves the problem of the Diols, also including 1,2-hexanediol and 2,3-hexanediol This can be achieved by combining, for example, 1,2-heptanediol and 2,3-heptanediol. ol, and combinations also including 1,2-octanediol and 2,3-octanediol The same effect is observed especially in combination with 2,3-nonanediol. 2-nonanediol, and 1,2-undecanediol in combination with 2,3-undecanediol. The same applies to candiol.

[0130] 1,2-alkanediols and the corresponding 2,3-alkanediols in combination with antimicrobial components The homoalkanediol mixtures described above, including alkanediols, are significantly synergistic. The corresponding and identical concentrations of 1,2-alkanediols or is clearly superior to 2,3-alkanediols.

[0131] In a particularly preferred variant, at least one first linear alkanediol and one or more or a mixture or combination of second linear alkanediols. The composition according to the invention thus comprises any one of the following mixtures / combinations: 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-Nonanediol, 1,2-Decanediol, 1,2-Undecanediol, 1, 2-Doedecanediol (1,2-doedecanediol), or 1,2-trimethylolpropanediol 1,2-pentanediol combined with one of the redecanediols; 1,2-pentanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-Nonanediol, 1,2-Decanediol, 1,2-Undecanediol, 1, 1 in combination with either 2-doedecanediol or 1,2-tridecanediol ,2-hexanediol; 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-Nonanediol, 1,2-Decanediol, 1,2-Undecanediol, 1, 1 in combination with either 2-doedecanediol or 1,2-tridecanediol ,2-heptanediol; 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-Nonanediol, 1,2-Decanediol, 1,2-Undecanediol, 1, 1 in combination with either 2-doedecanediol or 1,2-tridecanediol ,2-octanediol; 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-decanediol, 1,2-undecanediol, 1 ,2-doedecanediol, or 1,2-tridecanediol 1,2-nonanediol; 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-undecanediol, 1 ,2-doedecanediol, or 1,2-tridecanediol 1,2-Decanediol; 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2 1,2-dodecanediol or 1,2-tridecanediol -undecanediol; 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2 -undecanediol, or 1,2-tridecanediol in combination with one of 2-Dodecanediol; 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2 -undecanediol or 1,2-doedecanediol in combination with 2-Tridecanediol; 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-Nonanediol, 1,2-Decanediol, 1,2-Undecanediol, 1, 2 in combination with either 2-doedecanediol or 1,2-tridecanediol ,3-pentanediol; 1,2-pentanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-Nonanediol, 1,2-Decanediol, 1,2-Undecanediol, 1, 2 in combination with either 2-doedecanediol or 1,2-tridecanediol ,3-hexanediol; 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-Nonanediol, 1,2-Decanediol, 1,2-Undecanediol, 1, 2 in combination with either 2-doedecanediol or 1,2-tridecanediol ,3-heptanediol; 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-Nonanediol, 1,2-Decanediol, 1,2-Undecanediol, 1, 2 in combination with either 2-doedecanediol or 1,2-tridecanediol ,3-octanediol; 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-decanediol, 1,2-undecanediol, 1 ,2-doedecanediol, or 1,2-tridecanediol 2,3-nonanediol; 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-undecanediol, 1 ,2-doedecanediol, or 1,2-tridecanediol 2,3-Decanediol; 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2 2,3-dodecanediol or 1,2-tridecanediol -undecanediol; 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2 -undecanediol, or 1,2-tridecanediol in combination with one of 3-dodecanediol; or 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2 2,3-undecanediol or 1,2-dodecanediol -Tridecanediol; 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-Nonanediol, 2,3-Decanediol, 2,3-Undecanediol, 2, 2,3-dodecanediol or 2,3-tridecanediol in combination with one of 3-pentanediol; 2,3-pentanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-Nonanediol, 2,3-Decanediol, 2,3-Undecanediol, 2, 2,3-dodecanediol or 2,3-tridecanediol in combination with one of 3-Hexanediol; 2,3-pentanediol, 2,3-hexanediol, 2,3-octanediol, 2,3-Nonanediol, 2,3-Decanediol, 2,3-Undecanediol, 2, 2,3-dodecanediol or 2,3-tridecanediol in combination with one of 3-heptanediol; 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-Nonanediol, 2,3-Decanediol, 2,3-Undecanediol, 2, 2,3-dodecanediol or 2,3-tridecanediol in combination with one of 3-octanediol; 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-decanediol, 2,3-undecanediol, 2 2,3-dodecanediol, or 2,3-tridecanediol ,3-nonanediol; 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-undecanediol, 2 2,3-dodecanediol, or 2,3-tridecanediol ,3-decanediol; 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3 2,3-dodecanediol or 2,3-tridecanediol -undecanediol; 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3 2, in combination with one of 2,3-tridecanediol, 2,3-undecanediol, or 2,3-tridecanediol 3-dodecanediol; or 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3 2,3-undecanediol or 2,3-dodecanediol -Tridecanediol.

[0132] Also particularly advantageous are 1,2-hexanediol and 1,2-octanediol. or a mixture of alkanediols including

[0133] In a particular preferred variant, at least one first linear alkanediol and one or a mixture or combination of two or more second linear alkanediols. The composition according to this embodiment may therefore comprise any of the following mixtures / combinations: a mixture containing 1,2-heptanediol and 1,2-pentanediol, or a mixture containing 1,2-heptanediol and 1,2-hexanediol, or a mixture containing 1,2-heptanediol and 1,2-octanediol, or a mixture containing 1,2-heptanediol and 1,2-nonanediol, or a mixture containing 1,2-heptanediol and 1,2-decanediol, or a mixture containing 1,2-heptanediol and 1,2-undecanediol, or a mixture containing 1,2-heptanediol and 1,2-dodecanediol, or A mixture containing 1,2-heptanediol and 1,2-tridecanediol.

[0134] In a particular preferred variant, at least one first linear alkanediol and one or a mixture or combination of two or more second linear alkanediols. The composition according to this embodiment may therefore comprise any of the following mixtures / combinations: a mixture containing 1,2-heptanediol and 2,3-heptanediol, or a mixture containing 1,2-heptanediol and 2,3-pentanediol, or a mixture containing 1,2-heptanediol and 2,3-hexanediol, or a mixture containing 1,2-heptanediol and 2,3-nonanediol, or a mixture containing 1,2-heptanediol and 2,3-decanediol, or a mixture containing 1,2-heptanediol and 2,3-undecanediol, or a mixture containing 1,2-heptanediol and 2,3-dodecanediol, or A mixture containing 1,2-heptanediol and 2,3-tridecanediol.

[0135] In a particular preferred variant, at least one first linear alkanediol and one or a mixture or combination of two or more second linear alkanediols. The composition according to this embodiment may therefore comprise any of the following mixtures / combinations: mixtures containing 1,2-pentanediol and 2,3-pentanediol, mixtures containing 1,2-pentanediol and 2,3-hexanediol, mixtures containing 1,2-pentanediol and 2,3-heptanediol, mixtures containing 1,2-pentanediol and 2,3-octanediol, mixtures containing 1,2-pentanediol and 2,3-nonanediol, mixtures containing 1,2-pentanediol and 2,3-decanediol, mixtures containing 1,2-pentanediol and 2,3-undecanediol, mixtures containing 1,2-pentanediol and 2,3-dodecanediol, mixtures containing 1,2-pentanediol and 2,3-tridecanediol, mixtures containing 1,2-hexanediol and 2,3-pentanediol, mixtures containing 1,2-hexanediol and 2,3-hexanediol, mixtures containing 1,2-hexanediol and 2,3-heptanediol, mixtures containing 1,2-hexanediol and 2,3-octanediol, mixtures containing 1,2-hexanediol and 2,3-nonanediol, mixtures containing 1,2-hexanediol and 2,3-decanediol, mixtures containing 1,2-hexanediol and 2,3-undecanediol, mixtures containing 1,2-hexanediol and 2,3-dodecanediol, mixtures containing 1,2-hexanediol and 2,3-tridecanediol, mixtures containing 1,2-heptanediol and 2,3-pentanediol, mixtures containing 1,2-heptanediol and 2,3-hexanediol, mixtures containing 1,2-heptanediol and 2,3-heptanediol, mixtures containing 1,2-heptanediol and 2,3-octanediol, mixtures containing 1,2-heptanediol and 2,3-nonanediol, mixtures containing 1,2-heptanediol and 2,3-decanediol, mixtures containing 1,2-heptanediol and 2,3-undecanediol, mixtures containing 1,2-heptanediol and 2,3-dodecanediol, 1,2-heptanediol and 2,3-tridecanediol, mixtures containing 1,2-octanediol and 2,3-pentanediol, mixtures containing 1,2-octanediol and 2,3-hexanediol, mixtures containing 1,2-octanediol and 2,3-heptanediol, mixtures containing 1,2-octanediol and 2,3-octanediol, mixtures containing 1,2-octanediol and 2,3-nonanediol, mixtures containing 1,2-octanediol and 2,3-decanediol, mixtures containing 1,2-octanediol and 2,3-undecanediol, mixtures containing 1,2-octanediol and 2,3-dodecanediol, mixtures containing 1,2-octanediol and 2,3-tridecanediol, mixtures containing 1,2-nonanediol and 2,3-pentanediol, mixtures containing 1,2-nonanediol and 2,3-hexanediol, mixtures containing 1,2-nonanediol and 2,3-heptanediol, mixtures containing 1,2-nonanediol and 2,3-octanediol, mixtures containing 1,2-nonanediol and 2,3-nonanediol, mixtures containing 1,2-nonanediol and 2,3-decanediol, mixtures containing 1,2-nonanediol and 2,3-undecanediol, mixtures containing 1,2-nonanediol and 2,3-dodecanediol, mixtures containing 1,2-nonanediol and 2,3-tridecanediol, mixtures containing 1,2-decanediol and 2,3-pentanediol, mixtures containing 1,2-decanediol and 2,3-hexanediol, mixtures containing 1,2-decanediol and 2,3-heptanediol, mixtures containing 1,2-decanediol and 2,3-octanediol, mixtures containing 1,2-decanediol and 2,3-nonanediol, mixtures containing 1,2-decanediol and 2,3-decanediol, mixtures containing 1,2-decanediol and 2,3-undecanediol, mixtures containing 1,2-decanediol and 2,3-dodecanediol, mixtures containing 1,2-decanediol and 2,3-tridecanediol, mixtures containing 1,2-undecanediol and 2,3-pentanediol, mixtures containing 1,2-undecanediol and 2,3-hexanediol, mixtures containing 1,2-undecanediol and 2,3-heptanediol, mixtures containing 1,2-undecanediol and 2,3-octanediol, mixtures containing 1,2-undecanediol and 2,3-nonanediol, mixtures containing 1,2-undecanediol and 2,3-decanediol, mixtures containing 1,2-undecanediol and 2,3-undecanediol, mixtures containing 1,2-undecanediol and 2,3-dodecanediol, mixtures containing 1,2-undecanediol and 2,3-tridecanediol, mixtures containing 1,2-dodecanediol and 2,3-pentanediol, mixtures containing 1,2-dodecanediol and 2,3-hexanediol, mixtures containing 1,2-dodecanediol and 2,3-heptanediol, mixtures containing 1,2-dodecanediol and 2,3-octanediol, mixtures containing 1,2-dodecanediol and 2,3-nonanediol, mixtures containing 1,2-dodecanediol and 2,3-decanediol, mixtures containing 1,2-dodecanediol and 2,3-undecanediol, a mixture containing 1,2-dodecanediol and 2,3-dodecanediol, or A mixture containing 1,2-dodecanediol and 2,3-tridecanediol.

[0136] In a particular preferred variant, at least one first linear alkanediol and one or a mixture or combination of two or more second linear alkanediols. The composition according to this embodiment may therefore comprise any of the following mixtures / combinations: mixtures containing 2,3-pentanediol and 2,3-hexanediol, mixtures containing 2,3-pentanediol and 2,3-heptanediol, mixtures containing 2,3-pentanediol and 2,3-octanediol, mixtures containing 2,3-pentanediol and 2,3-nonanediol, mixtures containing 2,3-pentanediol and 2,3-decanediol, mixtures containing 2,3-pentanediol and 2,3-undecanediol, mixtures containing 2,3-pentanediol and 2,3-dodecanediol, mixtures containing 2,3-pentanediol and 2,3-tridecanediol, mixtures containing 2,3-hexanediol and 2,3-pentanediol, mixtures containing 2,3-hexanediol and 2,3-heptanediol, mixtures containing 2,3-hexanediol and 2,3-octanediol, mixtures containing 2,3-hexanediol and 2,3-nonanediol, mixtures containing 2,3-hexanediol and 2,3-decanediol, mixtures containing 2,3-hexanediol and 2,3-undecanediol, mixtures containing 2,3-hexanediol and 2,3-dodecanediol, mixtures containing 2,3-hexanediol and 2,3-tridecanediol, mixtures containing 2,3-heptanediol and 2,3-pentanediol, mixtures containing 2,3-heptanediol and 2,3-hexanediol, mixtures containing 2,3-heptanediol and 2,3-octanediol, mixtures containing 2,3-heptanediol and 2,3-nonanediol, mixtures containing 2,3-heptanediol and 2,3-decanediol, mixtures containing 2,3-heptanediol and 2,3-undecanediol, mixtures containing 2,3-heptanediol and 2,3-dodecanediol, mixtures containing 2,3-heptanediol and 2,3-tridecanediol, mixtures containing 2,3-octanediol and 2,3-pentanediol, mixtures containing 2,3-octanediol and 2,3-hexanediol, mixtures containing 2,3-octanediol and 2,3-heptanediol, mixtures containing 2,3-octanediol and 2,3-nonanediol, mixtures containing 2,3-octanediol and 2,3-decanediol, mixtures containing 2,3-octanediol and 2,3-undecanediol, mixtures containing 2,3-octanediol and 2,3-dodecanediol, mixtures containing 2,3-octanediol and 2,3-tridecanediol, mixtures containing 2,3-nonanediol and 2,3-pentanediol, mixtures containing 2,3-nonanediol and 2,3-hexanediol, mixtures containing 2,3-nonanediol and 2,3-heptanediol, mixtures containing 2,3-nonanediol and 2,3-octanediol, mixtures containing 2,3-nonanediol and 2,3-decanediol, mixtures containing 2,3-nonanediol and 2,3-undecanediol, mixtures containing 2,3-nonanediol and 2,3-dodecanediol, mixtures containing 2,3-nonanediol and 2,3-tridecanediol, mixtures containing 2,3-decanediol and 2,3-pentanediol, mixtures containing 2,3-decanediol and 2,3-hexanediol, mixtures containing 2,3-decanediol and 2,3-heptanediol, mixtures containing 2,3-decanediol and 2,3-octanediol, mixtures containing 2,3-decanediol and 2,3-nonanediol, mixtures containing 2,3-decanediol and 2,3-undecanediol, mixtures containing 2,3-decanediol and 2,3-dodecanediol, mixtures containing 2,3-decanediol and 2,3-tridecanediol, mixtures containing 2,3-undecanediol and 2,3-pentanediol, mixtures containing 2,3-undecanediol and 2,3-hexanediol, mixtures containing 2,3-undecanediol and 2,3-heptanediol, mixtures containing 2,3-undecanediol and 2,3-octanediol, mixtures containing 2,3-undecanediol and 2,3-nonanediol, mixtures containing 2,3-undecanediol and 2,3-decanediol, mixtures containing 2,3-undecanediol and 2,3-dodecanediol, mixtures containing 2,3-undecanediol and 2,3-tridecanediol, mixtures containing 2,3-dodecanediol and 2,3-pentanediol, mixtures containing 2,3-dodecanediol and 2,3-hexanediol, mixtures containing 2,3-dodecanediol and 2,3-heptanediol, mixtures containing 2,3-dodecanediol and 2,3-octanediol, mixtures containing 2,3-dodecanediol and 2,3-nonanediol, mixtures containing 2,3-dodecanediol and 2,3-decanediol, mixtures containing 2,3-dodecanediol and 2,3-undecanediol, A mixture containing 2,3-dodecanediol and 2,3-tridecanediol.

[0137] Particularly advantageous are 2,3-hexanediol and 2,3-heptanediol. Mixtures or combinations, or 2,3-hexanediol and 2,3-octanediol or a mixture containing 2,3-heptanediol and 2,3-octanediol It is a mixture of

[0138] In the previously described heteroalkanediol mixtures, the first linear alkanediol The first linear alkanediol and the second linear alkanediol have different numbers of carbon atoms.

[0139] At least one first linear alkanediol and one or more second linear alkanediols The heteroalkanediol mixture as described above according to the second aspect of the present invention, which contains an alkanediol. When used in combination with an antimicrobial component, as demonstrated in the examples below, Thus, the activity of all alkanediols against a wide range of microorganisms compared to each single alkanediol substance is It is characterized by synergistic antimicrobial efficacy against bacteria, yeast and fungi / molds. , synergistic antimicrobial effects are known to be achieved only with great difficulty. andida, e.g., Candida albicans and Aspergillus , even Aspergillus brasiliensis, for example.

[0140] Of the above-mentioned alkanediol mixtures, 1,2-hexanediol is particularly advantageous. and a heteroalkanediol mixture containing 2,3-octanediol, or 1,2- Heteroalkanediol mixture containing octanediol and 2,3-hexanediol or heteroalkanes including 1,2-octanediol and 2,3-heptanediol These are mixtures of the corresponding single 1,2-alkanediols or 2 ,3-alkanediol substances, namely 1,2-hexanediol or 1,2-octanol Tandiol, or 2,3-octanediol, or 2,3-hexanediol, or It exhibits synergistic antimicrobial effects compared to 2,3-heptanediol or 2,3-heptanediol.

[0141] The synergistic antimicrobial effect or action, when used in combination with an antimicrobial agent, Found in heterogeneous mixtures containing 1,2-hexanediol and 2,3-octanediol can be.

[0142] The synergistic antimicrobial effect is due to the use of 1,2-octanediol and It is also observed in heterogeneous mixtures containing 2,3-hexanediol and 2,3-hexanediol.

[0143] 1,2-octanediol and 2,3-heptanediol in combination with antimicrobial agents Heteromixtures comprising: are particularly beneficial as they have a particular, significant synergistic antimicrobial effect.

[0144] Furthermore, it has a unique broad spectrum of activity against microorganisms, i.e. bacteria, yeasts and fungi / molds. The effective antimicrobial effect is achieved when used in combination with the following antimicrobial components: Alkanediol mixture, namely 1,2-pentanediol and 2,3-hexanediol A mixture of alkanediols containing 1,2-pentanediol and 1,2 -heptanediol, or a mixture containing 1,2-pentanediol and 2,3-heptanediol Mixtures containing 1,2-pentanediol and 2,3-octanediol or a mixture containing 1,2-pentanediol and 1,2-nonanediol or a mixture containing 1,2-pentanediol and 2,3-nonanediol It can also be observed in objects.

[0145] at least one first linear alkanediol and one or more second alkanes The heteroalkanediol mixtures described above, including diols, are antimicrobial components and When used in combination, they exhibit synergistic activity by inhibiting microbial growth.

[0146] Heteromixtures containing 1,2-pentanediol and 2,3-hexanediol exhibited anti- When used in combination with microbial components, it has a particular and significant synergistic antimicrobial effect. This is particularly useful as

[0147] Alkanediol blend containing 1,2-pentanediol and 1,2-heptanediol Alkanes containing 1,2-pentanediol and 2,3-heptanediol Diol mixtures are particularly advantageous.

[0148] Similarly, synergistic antimicrobial effects or actions may occur when antimicrobial components are used in combination. When used in combination with 1,2-pentanediol and 2,3-octanediol, It is found in.

[0149] Also, alkanediols including 1,2-pentanediol and 1,2-nonanediol Alkyl mixtures containing 1,2-pentanediol and 2,3-nonanediol The benzol mixture, when used in combination with antimicrobial agents, synergistically reduces microbial load. To lower.

[0150] Furthermore, it has a unique broad spectrum of activity against microorganisms, i.e. bacteria, yeasts and fungi / molds. The effective antimicrobial effect is achieved when used in combination with the following antimicrobial components: Alkanediol mixture, namely 1,2-heptanediol and 1,2-octanediol A mixture of alkanediols containing 1,2-heptanediol and 2,3 -A mixture of alkanediols containing octanediol or 1,2-heptanediol and a mixture of alkanediols containing 1,2-nonanediol, or 1,2-hepta Mixtures or combinations of alkanediols containing nonanediol and 2,3-nonanediol It can also be observed.

[0151] Alkanediol blend containing 1,2-heptanediol and 1,2-octanediol Alkanes containing 1,2-heptanediol and 2,3-octanediol The diol mixture is particularly advantageous when used in combination with an antimicrobial component.

[0152] Also, alkanediols including 1,2-heptanediol and 1,2-nonanediol Alkyl mixtures containing 1,2-heptanediol and 2,3-nonanediol The phendiol mixture, when used in combination with different antimicrobial agents, reduces the microbial load comparatively. It reduces exponentially.

[0153] Use of Alkanediol Mixtures in Combination with Previously Described Antimicrobial Components inhibiting microbial growth by the use of the corresponding single alkanediol substance. In comparison, it has a broad spectrum of activity against microorganisms, i.e., bacteria, yeasts and fungi / molds. Thus, a synergistic antimicrobial effect is obtained.

[0154] A first linear alkanediol in combination with an antimicrobial component, and a second linear alkanediol The use of the above-described alkanediol mixture containing alkanediols makes it possible to Microbial growth in cosmetic or pharmaceutical compositions, or in home care products, is highly contagious. The microbial load in such preparations may be inhibited and thus reduced.

[0155] Therefore, the storage stability of such formulations can be significantly improved, and thus the shelf life. Furthermore, the risk of deterioration during use by the individual user is significantly reduced. .

[0156] In a preferred variant according to the second aspect of the invention, the composition comprises a linear alkanediol 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol , 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2, 3-Undecanediol, 2,3-Dodecanediol, 2,3-Tridecanediol and and mixtures thereof.

[0157] A preferred embodiment of the present invention in a cosmetic or pharmaceutical composition or home care product is In a preferred variant, the linear alkanediol is 2,3-pentanediol, 2,3-hexanediol, 2,3-Heptanediol, 2,3-Octanediol, 2,3-Nonanediol ol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanedio The olefin copolymer is selected from the group consisting of 2,3-tridecanediol, 2,3-tridecanediol, and mixtures thereof.

[0158] A preferred embodiment of the cosmetic, pharmaceutical composition or home care product according to the second aspect of the present invention is In a preferred variant, the linear alkanediol is 2,3-pentanediol, 2,3-hexanediol, 2,3-Heptanediol, 2,3-Octanediol, 2,3-Nonanediol ols, and mixtures thereof.

[0159] Surprisingly, 2,3-pentanediol, 2,3-hexanone, in combination with antimicrobial components Sandiol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonane Diol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol The use of 2,3-tridecanediol and 2,3-tridecanediol as described herein Inhibiting microbial growth in combination with other compounds provides an improved or synergistic antimicrobial effect.

[0160] As a result, the storage stability of such formulations can be significantly improved, and thus the shelf life. Furthermore, the risk of deterioration during use by the individual user is significantly reduced. .

[0161]

[0162] Furthermore, the above-mentioned 2,3-alkanediols have the advantage of being liquid, whereby Furthermore, its excellent solubility allows for the incorporation of This results in a higher concentration of 2,3-alkanediols in the final formulation.

[0163] Thus, the active antimicrobial mixture can be used in formulations while maintaining antimicrobial efficacy. When combined to improve workability, a good balance can be achieved. ,3-alkanediols outperform solid 1,2-alkanediol materials in this balance. Solve the problem.

[0164] Antimicrobial effect of the alkanediols or alkanediol mixtures described above The enrichment of microorganisms in food, or cosmetic or pharmaceutical compositions, or home care products. Low concentrations of antimicrobials are needed to reduce or even inhibit growth of It also has the advantage of being a component.

[0165] In a particularly advantageous variant according to the second aspect of the invention, the linear alkanediol, or first The linear alkanediol, or second linear alkanediol, is a liquid alkanediol. be.

[0166] The term "liquid alkanediol" within the context of the present invention refers to a liquid alkanediol at room or ambient temperature. Alkanediols that are liquid at room temperature and under normal pressure, i.e., standard RTP conditions It means a constituent.

[0167] In a highly preferred variant according to the second aspect of the invention, a linear alkanediol, or The first linear alkanediol or the second linear alkanediol is 1,2-hexanediol. Diol, 2,3-hexanediol, 1,2-heptanediol, 2,3-heptanediol ol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol , 2,3-undecanediol, and mixtures thereof. It is a lucanediol.

[0168] Of the liquid alkanediols mentioned above, 1,2-pentanediol, 2,3-pentanediol, 1,2-Hexanediol, 2,3-Hexanediol, 1,2-Heptanediol 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol or a mixture thereof is most preferred.

[0169] In a further particularly advantageous variant according to the second aspect of the invention, a linear alkanediol, or The first linear alkanediol or the second linear alkanediol is present in an amount of 10% by weight or less. In a preferred variant, the diol is a linear alkanediol, or The maximum water solubility of the first linear alkanediol or the second linear alkanediol is 1 0% by weight or less and 1.2% by weight or more. More preferred linear alkanediols, or The maximum water solubility of the first linear alkanediol or the second linear alkanediol is 5 % by weight or less and 1.4% by weight or more.

[0170] Preferably, the water-soluble alkanediol is 1,2-heptanediol, Consists of 2,3-heptanediol, 2,3-octanediol, and mixtures thereof is selected from the group.

[0171] The water solubility of a substance is the saturation mass concentration of the substance in water at a given temperature. The determination of solubility in water is based on essentially pure substances that are stable in water and are not volatile. The determination of the aqueous solubility of alkanediols is further described in Example 2 below. .

[0172] Within the context of the present invention, the term "alkanediol" also includes its stereoisomers. Stereoisomers are molecules that have the same molecular formula and differ only in the way the atoms are arranged in three-dimensional space. According to the above definition, the linear alkanediols of the present invention and alkanediols having 5 to 14 carbon atoms are a first linear alkanediol having a carbon chain of 1 to 14 carbon atoms, or The second linear alkanediol having a branched chain, as described above, particularly includes the following stereoisomers: Contains:

[0173] 1,2-Alkanediol Stereoisomers: (2S)-pentane-1,2-diol, (2S)-hexane-1,2-diol, (2S)-heptane-1,2-diol, (2S)-octane-1,2-diol, (2S)-nonane-1,2-diol, (2S)-decane-1,2-diol, (2S)-Undecane-1,2-diol (2S)-dodecane-1,2-diol, (2S)-tridecane-1,2-diol, (2S)-tetradecane-1,2-diol, (2R)-pentane-1,2-diol, (2R)-hexane-1,2-diol, (2R)-heptane-1,2-diol, (2R)-octane-1,2-diol, (2R)-nonane-1,2-diol, (2R)-decane-1,2-diol, (2R)-undecane-1,2-diol, (2R)-dodecane-1,2-diol, (2R)-tridecane-1,2-diol, (2R)-tetradecane-1,2-diol,

[0174] 2,3-Alkanediol Stereoisomers: (2S,3S)-pentane-2,3-diol, (2S,3S)-hexane-2,3-diol, (2S,3S)-heptane-2,3-diol, (2S,3S)-octane-2,3-diol, (2S,3S)-nonane-2,3-diol, (2S,3S)-decane-2,3-diol, (2S,3S)-Undecane-2,3-diol (2S,3S)-dodecane-2,3-diol, (2S,3S)-tridecane-2,3-diol, (2S,3S)-tetradecane-2,3-diol, (2R,3R)-pentane-2,3-diol, (2R,3R)-hexane-2,3-diol, (2R,3R)-heptane-2,3-diol, (2R,3R)-octane-2,3-diol, (2R,3R)-nonane-2,3-diol, (2R,3R)-decane-2,3-diol, (2R,3R)-undecane-2,3-diol, (2R,3R)-dodecane-2,3-diol, (2R,3R)-tridecane-2,3-diol, (2R,3R)-tetradecane-2,3-diol, (2S,3R)-pentane-2,3-diol, (2S,3R)-hexane-2,3-diol, (2S,3R)-heptane-2,3-diol, (2S,3R)-octane-2,3-diol, (2S,3R)-nonane-2,3-diol, (2S,3R)-decane-2,3-diol, (2S,3R)-undecane-2,3-diol, (2S,3R)-dodecane-2,3-diol, (2S,3R)-tridecane-2,3-diol, (2S,3R)-tetradecane-2,3-diol, (2R,3S)-pentane-2,3-diol, (2R,3S)-hexane-2,3-diol, (2R,3S)-heptane-2,3-diol, (2R,3S)-octane-2,3-diol, (2R,3S)-nonane-2,3-diol, (2R,3S)-decane-2,3-diol, (2R,3S)-undecane-2,3-diol, (2R,3S)-dodecane-2,3-diol, (2R,3S)-tridecane-2,3-diol, and (2R,3S)-Tetradecane-2,3-diol.

[0175] 3,4-Alkanediol Stereoisomers: (3R,4R)-hexane-3,4-diol, (3R,4R)-heptane-3,4-diol, (3R,4R)-octane-3,4-diol, (3R,4R)-nonane-3,4-diol, (3R,4R)-decane-3,4-diol, (3R,4R)-undecane-3,4-diol, (3R,4R)-dodecane-3,4-diol, (3R,4R)-tridecane-3,4-diol, (3R,4R)-tetradecane-3,4-diol, (3S,4S)-hexane-3,4-diol, (3S,4S)-heptane-3,4-diol, (3S,4S)-octane-3,4-diol, (3S,4S)-nonane-3,4-diol, (3S,4S)-decane-3,4-diol, (3S,4S)-undecane-3,4-diol, (3S,4S)-dodecane-3,4-diol, (3S,4S)-tridecane-3,4-diol, (3S,4S)-tetradecane-3,4-diol, (3R,4S)-hexane-3,4-diol, (3R,4S)-heptane-3,4-diol, (3R,4S)-octane-3,4-diol, (3R,4S)-nonane-3,4-diol, (3R,4S)-decane-3,4-diol, (3R,4S)-undecane-3,4-diol, (3R,4S)-dodecane-3,4-diol, (3R,4S)-tridecane-3,4-diol, (3R,4S)-tetradecane-3,4-diol, (3S,4R)-hexane-3,4-diol, (3S,4R)-heptane-3,4-diol, (3S,4R)-octane-3,4-diol, (3S,4R)-nonane-3,4-diol, (3S,4R)-decane-3,4-diol, (3S,4R)-undecane-3,4-diol, (3S,4R)-dodecane-3,4-diol, (3S,4R)-tridecane-3,4-diol, and (3S,4R)-Tetradecane-3,4-diol.

[0176] In connection with this text, "1,2-diol", "2,3-diol" or "3,4-diol" The term "aromatic" refers to both the corresponding S-configured enantiomer and also the R-enantiomer, if any. and any mixtures of these S- and R-configured enantiomers, i.e. i.e., it includes a racemic mixture of each diol.

[0177] The alkanediol mixture of the composition according to the first aspect of the invention is preferably a 1,2-heptanedioic acid diol. and 2,3-heptanediol in ratios ranging from 50:50 to 99.9:0.1. , preferably in a ratio ranging from 75:25 to 99:1, and more preferably in a ratio ranging from 80:20 to 98:2 is more preferred, with ratios ranging from 90:10 to 95:5 being even more preferred.

[0178] In the composition according to the first aspect of the invention for use in a cosmetic or pharmaceutical composition, 1,2- Heptanediol and 2,3-heptanediol are preferably in a ratio of 98:2 to 99.9 :0.1 range of alkanediol mixture.

[0179] In the composition according to the first aspect of the invention for use in home care products, 1,2-heptane The diol and 2,3-heptanediol are preferably in a ratio of 95:5 to 99.9:0.1 The alkanediol mixture is contained in a ratio in the range of

[0180] Preferably, 1,2-heptanediol and 2,3-heptanediol are used in the present invention. The alkanediol mixture of the composition according to the first aspect is present in a ratio of ≧95:≦5, A ratio of ≥97:≤4 is more preferred, a ratio of ≥97:≤3 is even more preferred, and a ratio of ≥98:≤2 is is most preferred.

[0181] The majority of all the alkanediol mixtures of the composition according to the first aspect of the invention are 1, 2-heptanediol and 2,3-heptanediol in a ratio of ≧95:≦5, 5.5:≦4.5; ≧96:≦4; ≧96.5:≦3.5; ≧97:≦3; ≧97.5: 2.5 and ratios of ≥ 98.0: ≤ 2.0.

[0182] An even more preferred alkanediol mixture for the composition according to the first aspect of the present invention comprises 1, 2-heptanediol and 2,3-heptanediol in a ratio of ≧98:≦2, 8.1: ≦1.9; ≧98.2: ≦1.8; ≧98.3: ≦1.7; ≧98.4: ≦1. 6; ≥98.5: ≤1.5; ≥98.6: ≤1.4; ≥98.7: ≤1.3; ≥98.8 :≦1.2;≧98.9:≦1.1;≧99:≦1.0;≧99.1:≦0.9;≧99 .2:≦0.8; ≧99.3:≦0.7; ≧99.4:≦0.6; ≧99.5:≦0.5 ;≧99.6:≦0.4;≧99.7:≦0.3;≧99.8:≦0.2 and ≧99. 9: Including ratios of ≦0.1.

[0183] a first linear alkanediol and a second linear alkanediol as defined in detail above; The alkanediol mixture of the composition according to the second aspect of the invention is in a proportion of 50:50 to 90:10. 9.9:0.1, preferably in a ratio ranging from 75:25 to 99:1, A ratio in the range of 80:20 to 98:2 is more preferred, with a ratio in the range of 90:10 to 95:5 is even more preferred.

[0184] In the composition according to the second aspect of the present invention for use in a cosmetic or pharmaceutical composition, the first line The cyclic alkanediol and the second linear alkanediol are preferably in a ratio of 98:2 to 99 Included in alkanediol mixtures in ratios ranging from 0.9:0.1

[0185] In the composition according to the second aspect of the present invention for use in home care products, the first linear alkali The ratio of the alkanediol and the second alkanediol is preferably from 95:5 to 99.9:0.1. The alkanediol mixture is contained in a ratio in the range of

[0186] Preferably, the first linear alkanediol and the second alkanediol are the same or different from the linear alkanediol of the present invention. The alkanediol mixture of the composition according to the second aspect is contained in a ratio of ≧95:≦5, A ratio of 6:≦4 is more preferred; a ratio of ≧97:≦3 is even more preferred, and a ratio of ≧98:≦2 is even more preferred. The ratio is most preferred.

[0187] The majority of all alkanediol mixtures of the compositions according to the second aspect of the invention are and a second linear alkanediol in a ratio of ≧95:≦5; ≥95.5: ≤4.5; ≥96: ≤4; ≥96.5: ≤3.5; ≥97: ≤3; ≥97. Including ratios of 5:2.5 and ≥98.0:≤2.0.

[0188] Even more preferred is a mixture of alkanediols of the composition according to the second aspect of the invention, and a second alkanediol in a ratio of ≧98:≦2, 8.1: ≦1.9; ≧98.2: ≦1.8; ≧98.3: ≦1.7; ≧98.4: ≦1. 6; ≥98.5: ≤1.5; ≥98.6: ≤1.4; ≥98.7: ≤1.3; ≥98.8 :≦1.2;≧98.9:≦1.1;≧99:≦1.0;≧99.1:≦0.9;≧99 .2:≦0.8; ≧99.3:≦0.7; ≧99.4:≦0.6; ≧99.5:≦0.5 ;≧99.6:≦0.4;≧99.7:≦0.3;≧99.8:≦0.2 and ≧99. 9: Including ratios of ≦0.1.

[0189] Alternatively, the above ratio ranges for the first and second alkanediols may be The alkanediol is the main component and the first alkanediol is the minor component. can.

[0190] In an advantageous variant according to the second aspect of the invention, the mixture comprises a first linear alkanediol and and 1,2-alkanediols, such as 1,2-pentanediol and 1,2-hexanediol. Diol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol 1,2-Decanediol, 1,2-Undecanediol, 1,2-Dodecanediol or 1,2-tridecanediol, and a second linear alkanediol, Corresponding 2,3-alkanediols, such as 2,3-pentanediol, 2,3-hexane Diol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol 2,3-Decanediol, 2,3-Undecanediol, 2,3-Dodecanediol or 2,3-tridecanediol in ratios ranging from 50:50 to 99.9:0.1 Preferably in a ratio ranging from 75:25 to 99:1, and more preferably in a range from 80:20 to 98:2. Ratios in the range of 90:10 to 95:5 are more preferred, with ratios in the range of 90:10 to 95:5 being even more preferred.

[0191] Similarly, in the mixture, the first linear alkanediol: the second linear alkanediol The ratio, or the above ratio range, applies.

[0192] In yet a further variation, according to the second aspect of the present invention, the mixture comprises a first linear alkane Diols include 2,3-alkanediols, such as 2,3-pentanediol, 2,3 -Hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3- Nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol alkanediol, or 2,3-tridecanediol, and a second linear alkanediol and the corresponding 1,2-alkanediols, such as 1,2-pentanediol, 1,2 -Hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2- Nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol or 1,2-tridecanediol in a ratio of 50:50 to 99.9:0.1 and preferably in a ratio ranging from 75:25 to 99:1, and more preferably in a ratio ranging from 80:20 to 9 A ratio in the range of 8:2 is more preferred, and a ratio in the range of 90:10 to 95:5 is even more preferred. It's nice.

[0193] Similarly, in the mixture, the first linear alkanediol: the second linear alkanediol The ratio, or the above ratio range, applies.

[0194] In a more advantageous variant according to the second aspect of the invention, the first linear alkanediol 1,2-alkanediols, and the corresponding 2,3 as the second linear alkanediol -mixtures containing combinations containing alkanediols, e.g. 1,2-pentanediol and 2,3-pentanediol, or 1,2-hexanediol and 2,3-hexanediol, or 1,2-heptanediol and 2,3-heptanediol, or 1,2-octanediol and 2,3-octanediol, or 1,2-nonanediol and 2,3-nonanediol, or 1,2-decanediol and 2,2-decanediol, or 1,2-undecanediol and 2,3-undecanediol, or 1,2-dodecanediol and 2,3-dodecanediol, or In 1,2-tridecanediol and 2,3-tridecanediol, The first linear alkanediol and the second linear alkanediol are in a ratio of 50:50 to 99:10. 0.9:0.1, preferably in a ratio ranging from 75:25 to 99:1, A ratio in the range of 0:20 to 98:2 is more preferred, and a ratio in the range of 90:10 to 95:5 is preferred. Even more preferred.

[0195] Similarly, in the mixture, the first linear alkanediol: the second linear alkanediol The ratio or range of ratios above applies.

[0196] With these mixing ratios, the previously mentioned mixtures can be used in combination with antimicrobial components. When used, they are directly related to the corresponding individual substances as described and demonstrated in the experimental part. The comparison shows synergistic antimicrobial efficacy.

[0197] In a more advantageous variant according to the second aspect of the invention, the first linear alkanediol is 2,3-alkanediols, and as a second linear alkanediol, the corresponding 1,2 mixtures containing alkanediols, e.g. 2,3-pentanediol and 1,2-pentanediol, or 2,3-hexanediol and 1,2-hexanediol, or 2,3-heptanediol and 1,2-heptanediol, or 2,3-octanediol and 1,2-octanediol, or 2,3-nonanediol and 1,2-nonanediol, or 2,3-decanediol and 1,2-decanediol, or 2,3-undecanediol and 1,2-undecenaediol, or 2,3-dodecanediol and 1,2-dodecanediol, or In a mixture containing 2,3-tridecanediol and 1,2-tridecanediol, The first linear alkanediol and the second linear alkanediol are in a ratio of 50:50 to 99:10. 0.9:0.1, preferably in a ratio ranging from 75:25 to 99:1, A ratio in the range of 0:20 to 98:2 is more preferred, and a ratio in the range of 90:10 to 95:5 is preferred. Even more preferred.

[0198] Similarly, in the mixture, the first linear alkanediol: the second linear alkanediol The ratio or range of ratios above applies.

[0199] With these mixing ratios, the mixtures mentioned above are compatible with those described and demonstrated in the experimental part. As shown in Figure 1, the improved solubility of lipid-soluble active substances is observed directly compared to the corresponding individual substances. .

[0200] A preferred variant according to the second aspect of the invention is a 1,2-alkanediol as the first linear alkanediol. -hexanediol, and 2,3-octanediol as the second linear alkanediol or a mixture containing 1,2-octanediol as the first linear alkanediol, and a mixture comprising 2,3-hexanediol as the second linear alkanediol, The first linear alkanediol was 1,2-octanediol, and the second linear alkanediol was The present invention also includes a mixture containing 2,3-heptanediol as the heptanediol, and the first linear alkali metal ion is The alkanediol and the second linear alkanediol range from 50:50 to 99.9:0.1. Preferably, the ratio ranges from 75:25 to 99:1, and more preferably from 80:20 to 98:1. A ratio in the range of 90:10 to 95:5 is even more preferred. stomach.

[0201] Similarly, in the mixture, the first linear alkanediol: the second linear alkanediol The ratio or range of ratios above applies.

[0202] With these mixing ratios, the previously mentioned mixtures can be used in combination with antimicrobial components. When used, they are directly related to the corresponding individual substances as described and demonstrated in the experimental part. The comparison shows synergistic antimicrobial efficacy.

[0203] In a further advantageous variant according to the second aspect of the invention, the mixture comprises a first linear alkanediol, ol and a second linear alkanediol, e.g. 1,2-pentanediol and 2,3-hexanediol, or 1,2-pentanediol and 1,2-heptanediol, or 1,2-pentanediol and 2,3-heptanediol, or 1,2-pentanediol and 2,3-octanediol, or 1,2-pentanediol and 1,2-nonanediol, or a mixture comprising 1,2-pentanediol and 2,3-nonanediol, The first linear alkanediol and the second linear alkanediol are in a ratio of 50:50 to 9 9.9:0.1, preferably in a ratio ranging from 75:25 to 99:1, A ratio in the range of 80:20 to 98:2 is more preferred, with a ratio in the range of 90:10 to 95:5 is even more preferred.

[0204] The ratio of the first linear alkanediol to the second linear alkanediol in the mixture is also Or the above ratio ranges apply.

[0205] With these mixing ratios, the previously mentioned mixtures can be used in combination with antimicrobial components. When used, they are directly related to the corresponding individual substances as described and demonstrated in the experimental part. The comparison shows synergistic antimicrobial efficacy.

[0206] A particularly preferred variant according to the second aspect of the invention is one in which the first linear alkanediol is 1 ,2-heptanediol, and 1,2-octanediol as the second linear alkanediol or a mixture containing 1,2-heptanediol as the first linear alkanediol and a mixture comprising 2,3-octanediol as the second linear alkanediol, Or 1,2-heptanediol as the first linear alkanediol and 1,2-heptanediol as the second linear alkanediol. a mixture containing 1,2-nonanediol as the alkanediol, or a first linear alkane 1,2-heptanediol as the diol, and 2 as the second linear alkanediol ,3-nonanediol, and a mixture of a first linear alkanediol and a second linear alkanediol. The linear alkanediols are preferably in a ratio ranging from 50:50 to 99.9:0.1, preferably 7 They are present in ratios ranging from 5:25 to 99:1, with ratios ranging from 80:20 to 98:2 being more preferred. Preferably, or even more preferably, a ratio in the range of 90:10 to 95:5.

[0207] Similarly, in the mixture, the first linear alkanediol: the second linear alkanediol The ratio or range of ratios above applies.

[0208] With these mixing ratios, the previously mentioned mixtures can be used in combination with antimicrobial components. When used, they are directly related to the corresponding individual substances as described and demonstrated in the experimental part. The comparison shows synergistic antimicrobial efficacy.

[0209] Alkanediols can be prepared by known methods, such as bishydroxylation of olefins, epoxy from petrochemical or other fossil fuel sources by hydrolysis or various chemical transformations , or from biological raw materials by fermentation, or US2019 / 0241491A1 and by catalytic synthesis as described in US2020 / 0189995A1. It is synthetically obtained from natural and renewable raw materials, such as biomass. The alkanediols used in accordance with the invention are of petrochemical origin as well as bio-based natural The alkanediols include those derived from natural and renewable raw materials. Preferably, the alkanediols is from a bio-based source and is therefore a bio-alkanediol .

[0210] The compound (b) of the composition according to the first or second aspect of the present invention is useful in many cosmetic preparations. Anti-inflammatory agents commonly used in skin care, hair care or body care products, or pharmaceutical products Concerning microbial components.

[0211] The term "antimicrobial component" in the context of the present invention refers to a substance, particularly a compound, that kills microorganisms. Antimicrobial agents refer to a group of agents that inhibit the growth of or against the microorganisms on which they primarily act. For example, antibiotics are used against bacteria, and antifungals are , are used against fungi, antiprotozoal drugs are used against protozoa, and antiviral drugs are used against viruses. These can also be classified according to their function: killing microorganisms Agents are biocidal or microbiocidal, but those that only inhibit their growth are bacteriostatic. It is said that...

[0212] The antimicrobial component according to the present invention is primarily directed against microorganisms, in particular bacteria, yeasts and / or fungi. The microorganisms mentioned are mesophilic aerobic bacteria that are undesirable in cosmetics. or yeast or fungus, and skin pathogen species that may be harmful to human health, or It is recognized as an indication of hygiene deficiencies in the manufacturing process. The microorganisms considered to be affected are Pseudomonas (bacteria), Staphylococcus aureus (bacteria), coccus (bacteria), Escherichia (bacteria), Candida (yeast) and Aspergillus (fungi) and combinations thereof.

[0213] More preferably, the microorganism is Pseudomonas aeruginosa, Staphylococcus aureus ... phylococcus aureus, Escherichia coli, Cand Ida albicans and Aspergillus brasiliensis and combinations thereof.

[0214] The composition according to the first or second aspect of the present invention comprises caprylhydroxamic acid, o-cymene -5-ol, isopropylparaben, capryloyl glycine, phenylpropanol, Tropolone, Cocoyl Arginate Ethyl PCA, 2-Methyl 5-Cyclohexylpentanoate ethanol, phenoxyethanol, EDTA disodium, methylparaben and its salts, Sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, Parapropylparaben, sodium methylparaben, methylchloroisothiazolinone, methylisothiazolinone Sothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, propyl Sodium paraben, DMDM ​​hydantoin, dehydroacetic acid, salicylic acid, chlorpheniramine Necin, isobutylparaben, ethylparaben sodium, diazolidinyl urea, diazo Lysinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytate sodium or phytic acid, sodium levulinate or levulinic acid and its esters, and / or ketals, chlorhexidine, glyceryl laurate, anisic acid and Salt, Chlorhexidine Digluconate, TEA Salicylate, Phenethyl Alcohol, Caprylic / Capric Triglyceride Glyceryl Phosphate, Sorbitan Caprylate, Tetrasodium Glutamate Diacetate, Ethylenediamine Distearate Amine disuccinate trisodium, hydroxyethoxyphenyl butanone, hydroxyethoxy Diphenylbutanol, Itaconic Acid, Octopirox, Propanedioic Acid Climbazole, Undecylenoylglycine, Thymol, 4-Hydroxyacetophenone Non, Lactic Acid, Sodium Lactate, Trisodium Dicarboxymethylalanine, Framb Non, Xylitol Caprylate, Benzoic Acid 3-Hydroxypropyl Ester, Anisic Acid 3 -Hydroxypropyl ester, 2-hydroxybenzoic acid 3-hydroxypropyl, 1, 3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2 -heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-de 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol 2,3-octanediol, 2,3-nonanediol, and the aforementioned antimicrobials At least one antimicrobial active ingredient selected from the group consisting of a mixture of two or more biological components It includes sexual components.

[0215] In a preferred variant, the antimicrobial active component is caprylhydroxamic acid, o-cymene- 5-ol, isopropylparaben, capryloyl glycine, phenylpropanol, Lactone, Cocoyl Arginate Ethyl PCA, 2-Methyl 5-Cyclohexylpentanoate Phenoxyethanol, EDTA disodium, methylparaben and its salts, benzoin Sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, pro Pilparaben, methylparaben sodium, methylchloroisothiazolinone, methyliso Thiazolinone, Ethylhexylglycerin, Butylparaben, Ethylparaben, Propyl Sodium paraben, DMDM ​​hydantoin, dehydroacetic acid, salicylic acid, chlorphene Synthetic, Isobutylparaben, Ethylparaben Sodium, Diazolidinyl Urea, Diazolidinyl Dinyl urea, farnesol, glyceryl caprylate, sodium phytate or phytosterol carboxylic acid, sodium levulinate or levulinic acid and its esters and / or ol, chlorhexidine, glyceryl laurate, anisic acid and its salts, digluconic acid Chlorhexidine, TEA salicylate, phenethyl alcohol, glyceryl caprate, Sorbitan caprylate, tetrasodium glutamate diacetate, ethylenediamine disuccinic acid Trisodium, Hydroxyethoxyphenylbutanone, Hydroxyethoxyphenylbutanone Alcohol, Itaconic Acid, Octopirox, Propanediol Caprylate, Climbazol , Undecylenoylglycine, Thymol, 4-Hydroxyacetophenone, Lactic Acid, Lactic Acid Sodium, Trisodium Dicarboxymethylalanine, Frambion, Caprylyl Xylitol, Benzoic acid 3-hydroxypropyl ester, Anisic acid 3-hydroxypropyl ester, 2-hydroxybenzoic acid 3-hydroxypropyl, 1,3-propanediol 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol , 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 2, 3-Pentanediol, 2,3-Hexanediol, 2,3-Heptanediol, 2,3 -octanediol, 2,3-nonanediol, and two of the aforementioned antimicrobial components The compound is selected from the group consisting of the above mixtures.

[0216] In a preferred variant, the antimicrobial component of the composition of the present invention is dehydroacetic acid, butyl carboxymethyl cellulose, Propynyl iodide benzoate, salicylic acid, chlorphenesin, isobutylparaben, ethyl Paraben Sodium, Diazolidinyl Urea, Diazolidinyl Urea, Farnesol, Bis(aminopropyl) Saborol, glyceryl caprylate, sodium phytate or phytic acid, levulinic acid sodium levulinate or levulinic acid and its esters and / or ketals, chlorhexidine Anisidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate , TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate Tan, tetrasodium glutamate diacetate, trisodium ethylenediamine disuccinate, milk Sodium caprylate, Frambion, Xylitol caprylate, 3-hydroxypropyl benzoate Pyr ester, 3-hydroxypropyl anisate, 3-hydroxybenzoic acid Hydroxypropyl, 1,3-propanediol, 1,2-pentanediol, 1,2- Hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-octanediol Nanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexane Diol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and mixtures of two or more of the foregoing antimicrobial components.

[0217] In a particularly preferred variant, the microbially active component of the composition of the invention is phenoxyethanol. EDTA disodium, methylparaben, sodium benzoate, benzyl alcohol , potassium sorbate, benzyl salicylate, propylparaben, methylparaben, methyl Dichloroisothiazolinone, Methylisothiazolinone, Ethylhexylglycerin, Butyl Paraben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin, Hydroxyethoxyphenylbutanone, Hydroxyethoxyphenylbutanol, Itacone Acid, Octirox, Propanediol Caprylate, Climbazole, 4-Hydroxypropyl Cetacetophenone, Frambinon, Xylitol Caprylate, 3-Hydroxybenzoate Propyl ester, 3-hydroxypropyl anisate, 2-hydroxybenzoic acid 3-Hydroxypropyl, 1,3-propanediol, 1,2-pentanediol, 1, 2-Hexanediol, 1,2-Heptanediol, 1,2-Octanediol, 1,2 -nonanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexanediol Sandiol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonane diols, and mixtures of two or more of the foregoing antimicrobial components. do.

[0218] In an even more preferred variant, the anti- The microbial components were 1,3-propanediol, 1,2-pentanediol, and 1,2-hexanediol. Xanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nona 1,2-Decanediol, 2,3-Pentanediol, 2,3-Hexanediol ol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and mixtures of two or more of the foregoing antimicrobial components. The antimicrobial component (b) of the composition according to the first and second aspects of the invention is a compound as previously identified. When the antimicrobial alkanediol component (b) is an alkanediol containing It is different from candiol component (a).

[0219] The aforementioned antimicrobial components may be used as the sole component or in combination with one or more further components. These may be used in combination with the antimicrobial components listed above to enhance antimicrobial efficacy. In addition, two or more antimicrobial components may be used to cover a wider range of antimicrobial effects. A combination of the two is preferably used.

[0220] In a preferred and advantageous variant, the composition according to the first or second aspect of the invention comprises Contains one of the following combinations of components (a) and (b): 1,2-pentanediol and one or more of the following antimicrobial components: dehydroacetic acid Acid, Iodopropynyl Butylcarbamate, Salicylic Acid, Chlorphenesin, Isobutyl Paraben, ethylparaben sodium, diazolidinyl urea, diazolidinyl urea, fa Lunesol, bisabolol, glyceryl caprylate, sodium phytate or phytate carboxylic acid, sodium levulinate or levulinic acid and its esters and / or Ketal, Chlorhexidine, Glyceryl Laurate, Anisic Acid and its Salts, Digluconate Chlorhexidine Phosphate, TEA Salicylate, Phenethyl Alcohol, Glyceryl Caprate sorbitan caprylate, tetrasodium glutamate diacetate, ethylenediamine diacetate Trisodium Lactate, Lactic Acid, Sodium Lactate, Frambinon, Xylitol Caprylate , benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-Hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2- Pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol 2,3-Heptanediol, 2,3-Octanediol, 2,3-Nonanediol ol, 1,2-decanediol or a mixture of two or more of the foregoing antimicrobial components; Ruiha 1,2-Hexanediol and one or more of the following antimicrobial components: Dehydroacetic acid Acid, Iodopropynyl Butylcarbamate, Salicylic Acid, Chlorphenesin, Isobutyl Paraben, ethylparaben sodium, diazolidinyl urea, diazolidinyl urea, fa Lunesol, bisabolol, glyceryl caprylate, sodium phytate or phytate carboxylic acid, sodium levulinate or levulinic acid and its esters and / or Ketal, Chlorhexidine, Glyceryl Laurate, Anisic Acid and its Salts, Digluconate Chlorhexidine Phosphate, TEA Salicylate, Phenethyl Alcohol, Glyceryl Caprate sorbitan caprylate, tetrasodium glutamate diacetate, ethylenediamine diacetate Trisodium Lactate, Lactic Acid, Sodium Lactate, Frambinon, Xylitol Caprylate , benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-Hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2- Pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol 2,3-Heptanediol, 2,3-Octanediol, 2,3-Nonanediol ol, 1,2-decanediol or a mixture of two or more of the foregoing antimicrobial components; Ruiha 1,2-heptanediol and one or more of the following antimicrobial components: dehydroacetic acid Acid, Iodopropynyl Butylcarbamate, Salicylic Acid, Chlorphenesin, Isobutyl Paraben, ethylparaben sodium, diazolidinyl urea, diazolidinyl urea, fa Lunesol, bisabolol, glyceryl caprylate, sodium phytate or phytate carboxylic acid, sodium levulinate or levulinic acid and its esters and / or Ketal, Chlorhexidine, Glyceryl Laurate, Anisic Acid and its Salts, Digluconate Chlorhexidine Phosphate, TEA Salicylate, Phenethyl Alcohol, Glyceryl Caprate sorbitan caprylate, tetrasodium glutamate diacetate, ethylenediamine diacetate Trisodium Lactate, Lactic Acid, Sodium Lactate, Frambinon, Xylitol Caprylate , benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-Hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2- Pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol 2,3-Heptanediol, 2,3-Octanediol, 2,3-Nonanediol ol, 1,2-decanediol or a mixture of two or more of the foregoing antimicrobial components; Ruiha 1,2-octanediol and one or more of the following antimicrobial components: dehydroacetic acid Acid, Iodopropynyl Butylcarbamate, Salicylic Acid, Chlorphenesin, Isobutyl Paraben, ethylparaben sodium, diazolidinyl urea, diazolidinyl urea, fa Lunesol, bisabolol, glyceryl caprylate, sodium phytate or phytate carboxylic acid, sodium levulinate or levulinic acid and its esters and / or Ketal, Chlorhexidine, Glyceryl Laurate, Anisic Acid and its Salts, Digluconate Chlorhexidine Phosphate, TEA Salicylate, Phenethyl Alcohol, Glyceryl Caprate sorbitan caprylate, tetrasodium glutamate diacetate, ethylenediamine diacetate Trisodium Lactate, Lactic Acid, Sodium Lactate, Frambinon, Xylitol Caprylate , benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-Hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2- Pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol 2,3-Heptanediol, 2,3-Octanediol, 2,3-Nonanediol ol, 1,2-decanediol or a mixture of two or more of the foregoing antimicrobial components; Ruiha 1,2-nonanediol and one or more of the following antimicrobial components: dehydroacetic acid , butylcarbamate iodopropynyl, salicylic acid, chlorphenesin, isobutylpa Raben, ethylparaben sodium, diazolidinyl urea, diazolidinyl urea, fal Nessol, bisabolol, glyceryl caprylate, sodium phytate or phytate carboxylic acid, sodium levulinate or levulinic acid and its esters and / or Tar, chlorhexidine, glyceryl laurate, anisic acid and its salts, digluconate Chlorhexidine acid, TEA salicylate, phenethyl alcohol, glyceryl caprate , Sorbitan caprylate, Tetrasodium glutamate diacetate, Ethylenediamine disuccinate Trisodium Caprylate, Lactic Acid, Sodium Lactate, Frambion, Xylityl Caprylate, Benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 2 -hydroxybenzoic acid 3-hydroxypropyl, 1,3-propanediol, 1,2-pentanediol 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol Tandanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexane Diol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol 1,2-decanediol or a mixture of two or more of the foregoing antimicrobial components; Iwa 1,2-decanediol and one or more of the following antimicrobial components: dehydroacetic acid , butylcarbamate iodopropynyl, salicylic acid, chlorphenesin, isobutylpa Raben, ethylparaben sodium, diazolidinyl urea, diazolidinyl urea, fal Nessol, bisabolol, glyceryl caprylate, sodium phytate or phytate carboxylic acid, sodium levulinate or levulinic acid and its esters and / or Tar, chlorhexidine, glyceryl laurate, anisic acid and its salts, digluconate Chlorhexidine acid, TEA salicylate, phenethyl alcohol, glyceryl caprate , Sorbitan caprylate, Tetrasodium glutamate diacetate, Ethylenediamine disuccinate Trisodium Caprylate, Lactic Acid, Sodium Lactate, Frambion, Xylityl Caprylate, Benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 2 -hydroxybenzoic acid 3-hydroxypropyl, 1,3-propanediol, 1,2-pentanediol 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol Tandanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexane Diol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol 1,2-decanediol or a mixture of two or more of the foregoing antimicrobial components; Iwa 1,2-undecanediol and one or more of the following antimicrobial components: dehydro Acetic acid, iodopropynyl butylcarbamate, salicylic acid, chlorphenesin, isobutyl Paraben, Ethylparaben Sodium, Diazolidinyl Urea, Diazolidinyl Urea, Farnesol, Bisabolol, Glyceryl Caprylate, Sodium Phytate or Phosphate levulinic acid, sodium levulinate or levulinic acid and its esters and / or Ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, diglycerides Chlorhexidine conate, TEA salicylate, phenethyl alcohol, capric acid glycerin sorbitan caprylate, tetrasodium glutamate diacetate, ethylenediamine diacetate Trisodium citrate, lactic acid, sodium lactate, Frambion, xylitol caprylate benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester , 2-hydroxybenzoic acid 3-hydroxypropyl, 1,3-propanediol, 1,2 -Pentanediol, 1,2-Hexanediol, 1,2-Heptanediol, 1,2- Octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol Sandiol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonane diol, 1,2-decanediol or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-dodecanediol and one or more of the following antimicrobial components: dehydroacetic acid Acid, Iodopropynyl Butylcarbamate, Salicylic Acid, Chlorphenesin, Isobutyl Paraben, ethylparaben sodium, diazolidinyl urea, diazolidinyl urea, fa Lunesol, bisabolol, glyceryl caprylate, sodium phytate or phytate carboxylic acid, sodium levulinate or levulinic acid and its esters and / or Ketal, Chlorhexidine, Glyceryl Laurate, Anisic Acid and its Salts, Digluconate Chlorhexidine Phosphate, TEA Salicylate, Phenethyl Alcohol, Glyceryl Caprate sorbitan caprylate, tetrasodium glutamate diacetate, ethylenediamine diacetate Trisodium Lactate, Lactic Acid, Sodium Lactate, Frambinon, Xylitol Caprylate , benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-Hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2- Pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol 2,3-Heptanediol, 2,3-Octanediol, 2,3-Nonanediol ol, 1,2-decanediol or a mixture of two or more of the foregoing antimicrobial components; Ruiha 1,2-tridecanediol and one or more of the following antimicrobial components: dehydro Acetic acid, iodopropynyl butylcarbamate, salicylic acid, chlorphenesin, isobutyl Paraben, Ethylparaben Sodium, Diazolidinyl Urea, Diazolidinyl Urea, Farnesol, Bisabolol, Glyceryl Caprylate, Sodium Phytate or Phosphate levulinic acid, sodium levulinate or levulinic acid and its esters and / or Ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, diglycerides Chlorhexidine conate, TEA salicylate, phenethyl alcohol, capric acid glycerin sorbitan caprylate, tetrasodium glutamate diacetate, ethylenediamine diacetate Trisodium citrate, lactic acid, sodium lactate, Frambion, xylitol caprylate benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester , 2-hydroxybenzoic acid 3-hydroxypropyl, 1,3-propanediol, 1,2 -Pentanediol, 1,2-Hexanediol, 1,2-Heptanediol, 1,2- Octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol Sandiol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonane diol, 1,2-decanediol or a mixture of two or more of the aforementioned antimicrobial components; or 2,3-pentanediol and one or more of the following antimicrobial components: dehydroacetic acid Acid, Iodopropynyl Butylcarbamate, Salicylic Acid, Chlorphenesin, Isobutyl Paraben, ethylparaben sodium, diazolidinyl urea, diazolidinyl urea, fa Lunesol, bisabolol, glyceryl caprylate, sodium phytate or phytate carboxylic acid, sodium levulinate or levulinic acid and its esters and / or Ketal, Chlorhexidine, Glyceryl Laurate, Anisic Acid and its Salts, Digluconate Chlorhexidine Phosphate, TEA Salicylate, Phenethyl Alcohol, Glyceryl Caprate sorbitan caprylate, tetrasodium glutamate diacetate, ethylenediamine diacetate Trisodium Lactate, Lactic Acid, Sodium Lactate, Frambinon, Xylitol Caprylate , benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-Hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2- Pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol 2,3-Heptanediol, 2,3-Octanediol, 2,3-Nonanediol ol, 1,2-decanediol or a mixture of two or more of the foregoing antimicrobial components; Ruiha 2,3-Hexanediol and one or more of the following antimicrobial components: Dehydroacetic acid Acid, Iodopropynyl Butylcarbamate, Salicylic Acid, Chlorphenesin, Isobutyl Paraben, ethylparaben sodium, diazolidinyl urea, diazolidinyl urea, fa Lunesol, bisabolol, glyceryl caprylate, sodium phytate or phytate carboxylic acid, sodium levulinate or levulinic acid and its esters and / or Ketal, Chlorhexidine, Glyceryl Laurate, Anisic Acid and its Salts, Digluconate Chlorhexidine Phosphate, TEA Salicylate, Phenethyl Alcohol, Glyceryl Caprate sorbitan caprylate, tetrasodium glutamate diacetate, ethylenediamine diacetate Trisodium Lactate, Lactic Acid, Sodium Lactate, Frambinon, Xylitol Caprylate , benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-Hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2- Pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol 2,3-Heptanediol, 2,3-Octanediol, 2,3-Nonanediol ol, 1,2-decanediol or a mixture of two or more of the foregoing antimicrobial components; Ruiha 2,3-heptanediol and one or more of the following antimicrobial components: dehydroacetic acid Acid, Iodopropynyl Butylcarbamate, Salicylic Acid, Chlorphenesin, Isobutyl Paraben, ethylparaben sodium, diazolidinyl urea, diazolidinyl urea, fa Lunesol, bisabolol, glyceryl caprylate, sodium phytate or phytate carboxylic acid, sodium levulinate or levulinic acid and its esters and / or Ketal, Chlorhexidine, Glyceryl Laurate, Anisic Acid and its Salts, Digluconate Chlorhexidine Phosphate, TEA Salicylate, Phenethyl Alcohol, Glyceryl Caprate sorbitan caprylate, tetrasodium glutamate diacetate, ethylenediamine diacetate Trisodium Lactate, Lactic Acid, Sodium Lactate, Frambinon, Xylitol Caprylate , benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-Hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2- Pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol 2,3-Heptanediol, 2,3-Octanediol, 2,3-Nonanediol ol, 1,2-decanediol or a mixture of two or more of the foregoing antimicrobial components; Ruiha 2,3-octanediol and one or more of the following antimicrobial components: dehydroacetic acid Acid, Iodopropynyl Butylcarbamate, Salicylic Acid, Chlorphenesin, Isobutyl Paraben, ethylparaben sodium, diazolidinyl urea, diazolidinyl urea, fa Lunesol, bisabolol, glyceryl caprylate, sodium phytate or phytate carboxylic acid, sodium levulinate or levulinic acid and its esters and / or Ketal, Chlorhexidine, Glyceryl Laurate, Anisic Acid and its Salts, Digluconate Chlorhexidine Phosphate, TEA Salicylate, Phenethyl Alcohol, Glyceryl Caprate sorbitan caprylate, tetrasodium glutamate diacetate, ethylenediamine diacetate Trisodium Lactate, Lactic Acid, Sodium Lactate, Frambinon, Xylitol Caprylate , benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-Hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2- Pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol 2,3-Heptanediol, 2,3-Octanediol, 2,3-Nonanediol ol, 1,2-decanediol or a mixture of two or more of the foregoing antimicrobial components; Ruiha 2,3-nonanediol and one or more of the following antimicrobial components: dehydroacetic acid , butylcarbamate iodopropynyl, salicylic acid, chlorphenesin, isobutylpa Raben, ethylparaben sodium, diazolidinyl urea, diazolidinyl urea, fal Nessol, bisabolol, glyceryl caprylate, sodium phytate or phytate carboxylic acid, sodium levulinate or levulinic acid and its esters and / or Tar, chlorhexidine, glyceryl laurate, anisic acid and its salts, digluconate Chlorhexidine acid, TEA salicylate, phenethyl alcohol, glyceryl caprate , Sorbitan caprylate, Tetrasodium glutamate diacetate, Ethylenediamine disuccinate Trisodium Caprylate, Lactic Acid, Sodium Lactate, Frambion, Xylityl Caprylate, Benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 2 -hydroxybenzoic acid 3-hydroxypropyl, 1,3-propanediol, 1,2-pentanediol 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol Tandanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexane Diol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol 1,2-decanediol or a mixture of two or more of the foregoing antimicrobial components; Iwa 2,3-decanediol and one or more of the following antimicrobial components: dehydroacetic acid , butylcarbamate iodopropynyl, salicylic acid, chlorphenesin, isobutylpa Raben, ethylparaben sodium, diazolidinyl urea, diazolidinyl urea, fal Nessol, bisabolol, glyceryl caprylate, sodium phytate or phytate carboxylic acid, sodium levulinate or levulinic acid and its esters and / or Tar, chlorhexidine, glyceryl laurate, anisic acid and its salts, digluconate Chlorhexidine acid, TEA salicylate, phenethyl alcohol, glyceryl caprate , Sorbitan caprylate, Tetrasodium glutamate diacetate, Ethylenediamine disuccinate Trisodium Caprylate, Lactic Acid, Sodium Lactate, Frambion, Xylityl Caprylate, Benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 2 -hydroxybenzoic acid 3-hydroxypropyl, 1,3-propanediol, 1,2-pentanediol 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol Tandanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexane Diol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol 1,2-decanediol or a mixture of two or more of the foregoing antimicrobial components; Iwa 2,3-undecanediol and one or more of the following antimicrobial components: dehydro Acetic acid, iodopropynyl butylcarbamate, salicylic acid, chlorphenesin, isobutyl Paraben, Ethylparaben Sodium, Diazolidinyl Urea, Diazolidinyl Urea, Farnesol, Bisabolol, Glyceryl Caprylate, Sodium Phytate or Phosphate levulinic acid, sodium levulinate or levulinic acid and its esters and / or Ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, diglycerides Chlorhexidine conate, TEA salicylate, phenethyl alcohol, capric acid glycerin sorbitan caprylate, tetrasodium glutamate diacetate, ethylenediamine diacetate Trisodium citrate, lactic acid, sodium lactate, Frambion, xylitol caprylate benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester , 2-hydroxybenzoic acid 3-hydroxypropyl, 1,3-propanediol, 1,2 -Pentanediol, 1,2-Hexanediol, 1,2-Heptanediol, 1,2- Octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol Sandiol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonane diol, 1,2-decanediol or a mixture of two or more of the aforementioned antimicrobial components; or 2,3-dodecanediol and one or more of the following antimicrobial components: dehydroacetic acid Acid, Iodopropynyl Butylcarbamate, Salicylic Acid, Chlorphenesin, Isobutyl Paraben, ethylparaben sodium, diazolidinyl urea, diazolidinyl urea, fa Lunesol, bisabolol, glyceryl caprylate, sodium phytate or phytate carboxylic acid, sodium levulinate or levulinic acid and its esters and / or Ketal, Chlorhexidine, Glyceryl Laurate, Anisic Acid and its Salts, Digluconate Chlorhexidine Phosphate, TEA Salicylate, Phenethyl Alcohol, Glyceryl Caprate sorbitan caprylate, tetrasodium glutamate diacetate, ethylenediamine diacetate Trisodium Lactate, Lactic Acid, Sodium Lactate, Frambinon, Xylitol Caprylate , benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-Hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2- Pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol 2,3-Heptanediol, 2,3-Octanediol, 2,3-Nonanediol ol, 1,2-decanediol or a mixture of two or more of the foregoing antimicrobial components; Ruiha 2,3-tridecanediol and one or more of the following antimicrobial components: dehydro Acetic acid, iodopropynyl butylcarbamate, salicylic acid, chlorphenesin, isobutyl Paraben, Ethylparaben Sodium, Diazolidinyl Urea, Diazolidinyl Urea, Farnesol, Bisabolol, Glyceryl Caprylate, Sodium Phytate or Phosphate levulinic acid, sodium levulinate or levulinic acid and its esters and / or Ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, diglycerides Chlorhexidine conate, TEA salicylate, phenethyl alcohol, capric acid glycerin sorbitan caprylate, tetrasodium glutamate diacetate, ethylenediamine diacetate Trisodium citrate, lactic acid, sodium lactate, Frambion, xylitol caprylate benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester , 2-hydroxybenzoic acid 3-hydroxypropyl, 1,3-propanediol, 1,2 -Pentanediol, 1,2-Hexanediol, 1,2-Heptanediol, 1,2- Octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol Sandiol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonane diol, 1,2-decanediol or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-pentanediol in combination with 2,3-pentanediol and the following antimicrobial One or more of the components: dehydroacetic acid, iodopropynyl butylcarbamate, saponin Licylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazo Lysinyl urea, diazolidinyl urea, farnesol, bisabolol, caprylic / glycerin phytate or phytic acid; sodium levulinate or levulinic acid acid and its esters and / or ketals, chlorhexidine, glycerin, laurate Seryl, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, Ethyl alcohol, glyceryl caprate, sorbitan caprylate, disodium glutamate Acid tetrasodium, ethylenediaminedisuccinate trisodium, lactic acid, sodium lactate, F Rambinon, xylitol caprylate, benzoic acid 3-hydroxypropyl ester, 3-Hydroxypropyl 2-hydroxybenzoate, 3-hydroxypropyl 2-hydroxybenzoate 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol , 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2 ,3-Pentanediol, 2,3-Hexanediol, 2,3-Heptanediol, 2, 3-octanediol, 2,3-nonanediol, 1,2-decanediol or the aforementioned a mixture of two or more antimicrobial components; or 1,2-Hexanediol in combination with 2,3-Hexanediol and the following antimicrobial One or more of the components: dehydroacetic acid, iodopropynyl butylcarbamate, saponin Licylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazo Lysinyl urea, diazolidinyl urea, farnesol, bisabolol, caprylic / glycerin phytate or phytic acid; sodium levulinate or levulinic acid acid and its esters and / or ketals, chlorhexidine, glycerin, laurate Seryl, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, Ethyl alcohol, glyceryl caprate, sorbitan caprylate, disodium glutamate Acid tetrasodium, ethylenediaminedisuccinate trisodium, lactic acid, sodium lactate, F Rambinon, xylitol caprylate, benzoic acid 3-hydroxypropyl ester, 3-Hydroxypropyl 2-hydroxybenzoate, 3-hydroxypropyl 2-hydroxybenzoate 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol , 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2 ,3-Pentanediol, 2,3-Hexanediol, 2,3-Heptanediol, 2, 3-octanediol, 2,3-nonanediol, 1,2-decanediol or the aforementioned a mixture of two or more antimicrobial components; or 1,2-heptanediol in combination with 2,3-heptanediol and the following antimicrobial One or more of the components: dehydroacetic acid, iodopropynyl butylcarbamate, saponin Licylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazo Lysinyl urea, diazolidinyl urea, farnesol, bisabolol, caprylic / glycerin phytate or phytic acid; sodium levulinate or levulinic acid acid and its esters and / or ketals, chlorhexidine, glycerin, laurate Seryl, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, Ethyl alcohol, glyceryl caprate, sorbitan caprylate, disodium glutamate Acid tetrasodium, ethylenediaminedisuccinate trisodium, lactic acid, sodium lactate, F Rambinon, xylitol caprylate, benzoic acid 3-hydroxypropyl ester, 3-Hydroxypropyl 2-hydroxybenzoate, 3-hydroxypropyl 2-hydroxybenzoate 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol , 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2 ,3-Pentanediol, 2,3-Hexanediol, 2,3-Heptanediol, 2, 3-octanediol, 2,3-nonanediol, 1,2-decanediol or the aforementioned a mixture of two or more antimicrobial components; or 1,2-octanediol in combination with 2,3-octanediol and the following antimicrobial One or more of the components: dehydroacetic acid, iodopropynyl butylcarbamate, saponin Licylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazo Lysinyl urea, diazolidinyl urea, farnesol, bisabolol, caprylic / glycerin phytate or phytic acid; sodium levulinate or levulinic acid acid and its esters and / or ketals, chlorhexidine, glycerin, laurate Seryl, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, Ethyl alcohol, glyceryl caprate, sorbitan caprylate, disodium glutamate Acid tetrasodium, ethylenediaminedisuccinate trisodium, lactic acid, sodium lactate, F Rambinon, xylitol caprylate, benzoic acid 3-hydroxypropyl ester, 3-Hydroxypropyl 2-hydroxybenzoate, 3-hydroxypropyl 2-hydroxybenzoate 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol , 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2 ,3-Pentanediol, 2,3-Hexanediol, 2,3-Heptanediol, 2, 3-octanediol, 2,3-nonanediol, 1,2-decanediol or the aforementioned a mixture of two or more antimicrobial components; or 1,2-nonanediol in combination with 2,3-nonanediol and the following antimicrobial structures: Ingredients: Dehydroacetic acid, iodopropynyl butylcarbamate, salicylic acid Acid, Chlorphenesin, Isobutylparaben, Ethylparaben Sodium, Diazolidinyl Nilurea, Diazolidinyl Urea, Farnesol, Bisabolol, Glyceryl Caprylate , sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketals, chlorhexidine, glyceryl laurate Anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenoxyethanol Alcohol, Glyceryl Caprate, Sorbitan Caprylate, Tetrasodium Glutamate Diacetate Sodium, Trisodium Ethylenediamine Disuccinate, Lactic Acid, Sodium Lactate, Fra Ambinon, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anise Acid 3-hydroxypropyl ester, 2-hydroxybenzoic acid 3-hydroxypropyl, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1 ,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3 -pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3- Octanediol, 2,3-nonanediol, 1,2-decanediol or any of the aforementioned antimicrobials a mixture of two or more biological components; or 1,2-decanediol in combination with 2,3-decanediol and the following antimicrobial structures: Ingredients: Dehydroacetic acid, iodopropynyl butylcarbamate, salicylic acid Acid, Chlorphenesin, Isobutylparaben, Ethylparaben Sodium, Diazolidinyl Nilurea, Diazolidinyl Urea, Farnesol, Bisabolol, Glyceryl Caprylate , sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or ketals, chlorhexidine, glyceryl laurate Anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenoxyethanol Alcohol, Glyceryl Caprate, Sorbitan Caprylate, Tetrasodium Glutamate Diacetate Sodium, Trisodium Ethylenediamine Disuccinate, Lactic Acid, Sodium Lactate, Fra Ambinon, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anise Acid 3-hydroxypropyl ester, 2-hydroxybenzoic acid 3-hydroxypropyl, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1 ,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3 -pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3- Octanediol, 2,3-nonanediol, 1,2-decanediol or any of the aforementioned antimicrobials a mixture of two or more biological components; or 1,2-undecanediol in combination with 2,3-undecanediol and the following anti- One or more of the microbial components: dehydroacetic acid, butylcarbamate, iodopropynyl , salicylic acid, chlorphenesin, isobutylparaben, ethylparaben sodium, di Azolidinyl urea, diazolidinyl urea, farnesol, bisabolol, caprylic acid glycerol Glyceryl, Sodium Phytate or Phytic Acid, Sodium Levulinate or Levulinate uric acid and its esters and / or ketals, chlorhexidine, lauric acid Glyceryl, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate , phenethyl alcohol, glyceryl caprate, sorbitan caprylate, glutamic acid Tetrasodium diacetate, trisodium ethylenediaminedisuccinate, lactic acid, sodium lactate , Frambinon, Xylitol Caprylate, Benzoic Acid 3-Hydroxypropyl Ester , anisic acid 3-hydroxypropyl ester, 2-hydroxybenzoic acid 3-hydroxypropyl propyl, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol , 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-dodecanediol in combination with 2,3-dodecanediol and the following antimicrobial One or more of the components: dehydroacetic acid, iodopropynyl butylcarbamate, saponin Licylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazo Lysinyl urea, diazolidinyl urea, farnesol, bisabolol, caprylic / glycerin phytate or phytic acid; sodium levulinate or levulinic acid acid and its esters and / or ketals, chlorhexidine, glycerin, laurate Seryl, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, Ethyl alcohol, glyceryl caprate, sorbitan caprylate, disodium glutamate Acid tetrasodium, ethylenediaminedisuccinate trisodium, lactic acid, sodium lactate, F Rambinon, xylitol caprylate, benzoic acid 3-hydroxypropyl ester, 3-Hydroxypropyl 2-hydroxybenzoate, 3-hydroxypropyl 2-hydroxybenzoate 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol , 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2 ,3-Pentanediol, 2,3-Hexanediol, 2,3-Heptanediol, 2, 3-octanediol, 2,3-nonanediol, 1,2-decanediol or the aforementioned a mixture of two or more antimicrobial components; or 1,2-tridecanediol in combination with 2,3-tridecanediol and the following anti- One or more of the microbial components: dehydroacetic acid, butylcarbamate, iodopropynyl , salicylic acid, chlorphenesin, isobutylparaben, ethylparaben sodium, di Azolidinyl urea, diazolidinyl urea, farnesol, bisabolol, caprylic acid glycerol Glyceryl, Sodium Phytate or Phytic Acid, Sodium Levulinate or Levulinate uric acid and its esters and / or ketals, chlorhexidine, lauric acid Glyceryl, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate , phenethyl alcohol, glyceryl caprate, sorbitan caprylate, glutamic acid Tetrasodium diacetate, trisodium ethylenediaminedisuccinate, lactic acid, sodium lactate , Frambinon, Xylitol Caprylate, Benzoic Acid 3-Hydroxypropyl Ester , anisic acid 3-hydroxypropyl ester, 2-hydroxybenzoic acid 3-hydroxypropyl propyl, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol , 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2-decanediol or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-Nonanediol, 1,2-Decanediol, 1,2-Undecanediol, 1, in combination with one or more of 2-dodecanediol or 1,2-tridecanediol 1,2-heptanediol and one or more of the following antimicrobial components: dehydroacetic acid Acid, Iodopropynyl Butylcarbamate, Salicylic Acid, Chlorphenesin, Isobutyl Paraben, ethylparaben sodium, diazolidinyl urea, diazolidinyl urea, fa Lunesol, bisabolol, glyceryl caprylate, sodium phytate or phytate carboxylic acid, sodium levulinate or levulinic acid and its esters and / or Ketal, Chlorhexidine, Glyceryl Laurate, Anisic Acid and its Salts, Digluconate Chlorhexidine Phosphate, TEA Salicylate, Phenethyl Alcohol, Glyceryl Caprate sorbitan caprylate, tetrasodium glutamate diacetate, ethylenediamine diacetate Trisodium Lactate, Lactic Acid, Sodium Lactate, Frambinon, Xylitol Caprylate , benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 3-Hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2- Pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol 2,3-Heptanediol, 2,3-Octanediol, 2,3-Nonanediol ol, 1,2-decanediol or a mixture of two or more of the foregoing antimicrobial components; Ruiha 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3 -undecanediol, 2,3-dodecanediol or 2,3-tridecanediol 1,2-heptanediol in combination with one or more of the following antimicrobial components: One or more of: Dehydroacetic acid, iodopropynyl butylcarbamate, salicylic acid, Lorfenesin, isobutylparaben, ethylparaben sodium, diazolidinyl urea , diazolidinyl urea, farnesol, bisabolol, glyceryl caprylate, phytosterol sodium phosphate or phytic acid, sodium levulinate or levulinic acid and Esters and / or ketals of chlorhexidine, glyceryl laurate, aniline Acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol Cole, glyceryl caprate, sorbitan caprylate, tetrasodium glutamate diacetate , trisodium ethylenediaminedisuccinate, lactic acid, sodium lactate, Frambini on, xylitol caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester Hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3- Propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-hexanediol Butanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol hexanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octane diol, 2,3-nonanediol, 1,2-decanediol or the aforementioned antimicrobial compositions a mixture of two or more ingredients; or 1,2-Hexanediol in combination with 2,3-Octanediol and the following antimicrobial One or more of the components: dehydroacetic acid, iodopropynyl butylcarbamate, saponin Licylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazo Lysinyl urea, diazolidinyl urea, farnesol, bisabolol, caprylic / glycerin phytate or phytic acid; sodium levulinate or levulinic acid acid and its esters and / or ketals, chlorhexidine, glycerin, laurate Seryl, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, Ethyl alcohol, glyceryl caprate, sorbitan caprylate, disodium glutamate Acid tetrasodium, ethylenediaminedisuccinate trisodium, lactic acid, sodium lactate, F Rambinon, xylitol caprylate, benzoic acid 3-hydroxypropyl ester, 3-Hydroxypropyl 2-hydroxybenzoate, 3-hydroxypropyl 2-hydroxybenzoate 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol , 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2 ,3-Pentanediol, 2,3-Hexanediol, 2,3-Heptanediol, 2, 3-octanediol, 2,3-nonanediol, 1,2-decanediol or the aforementioned a mixture of two or more antimicrobial components; or 1,2-octanediol in combination with 2,3-hexanediol and the following antimicrobial One or more of the components: dehydroacetic acid, iodopropynyl butylcarbamate, saponin Licylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazo Lysinyl urea, diazolidinyl urea, farnesol, bisabolol, caprylic / glycerin phytate or phytic acid; sodium levulinate or levulinic acid acid and its esters and / or ketals, chlorhexidine, glycerin, laurate Seryl, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, Ethyl alcohol, glyceryl caprate, sorbitan caprylate, disodium glutamate Acid tetrasodium, ethylenediaminedisuccinate trisodium, lactic acid, sodium lactate, F Rambinon, xylitol caprylate, benzoic acid 3-hydroxypropyl ester, 3-Hydroxypropyl 2-hydroxybenzoate, 3-hydroxypropyl 2-hydroxybenzoate 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol , 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2 ,3-Pentanediol, 2,3-Hexanediol, 2,3-Heptanediol, 2, 3-octanediol, 2,3-nonanediol, 1,2-decanediol or the aforementioned a mixture of two or more antimicrobial components; or 1,2-octanediol in combination with 2,3-heptanediol and the following antimicrobial One or more of the components: dehydroacetic acid, iodopropynyl butylcarbamate, saponin Licylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazo Lysinyl urea, diazolidinyl urea, farnesol, bisabolol, caprylic / glycerin phytate or phytic acid; sodium levulinate or levulinic acid acid and its esters and / or ketals, chlorhexidine, glycerin, laurate Seryl, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, Ethyl alcohol, glyceryl caprate, sorbitan caprylate, disodium glutamate Acid tetrasodium, ethylenediaminedisuccinate trisodium, lactic acid, sodium lactate, F Rambinon, xylitol caprylate, benzoic acid 3-hydroxypropyl ester, 3-Hydroxypropyl 2-hydroxybenzoate, 3-hydroxypropyl 2-hydroxybenzoate 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol , 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2 ,3-Pentanediol, 2,3-Hexanediol, 2,3-Heptanediol, 2, 3-octanediol, 2,3-nonanediol, 1,2-decanediol or the aforementioned a mixture of two or more antimicrobial components; or 1,2-pentanediol in combination with 2,3-hexanediol and the following antimicrobial One or more of the components: dehydroacetic acid, iodopropynyl butylcarbamate, saponin Licylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazo Lysinyl urea, diazolidinyl urea, farnesol, bisabolol, caprylic / glycerin phytate or phytic acid; sodium levulinate or levulinic acid acid and its esters and / or ketals, chlorhexidine, glycerin, laurate Seryl, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, Ethyl alcohol, glyceryl caprate, sorbitan caprylate, disodium glutamate Acid tetrasodium, ethylenediaminedisuccinate trisodium, lactic acid, sodium lactate, F Rambinon, xylitol caprylate, benzoic acid 3-hydroxypropyl ester, 3-Hydroxypropyl 2-hydroxybenzoate, 3-hydroxypropyl 2-hydroxybenzoate 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol , 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2 ,3-Pentanediol, 2,3-Hexanediol, 2,3-Heptanediol, 2, 3-octanediol, 2,3-nonanediol, 1,2-decanediol or the aforementioned a mixture of two or more antimicrobial components; or 1,2-pentanediol in combination with 1,2-heptanediol and the following antimicrobial One or more of the components: dehydroacetic acid, iodopropynyl butylcarbamate, saponin Licylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazo Lysinyl urea, diazolidinyl urea, farnesol, bisabolol, caprylic / glycerin phytate or phytic acid; sodium levulinate or levulinic acid acid and its esters and / or ketals, chlorhexidine, glycerin, laurate Seryl, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, Ethyl alcohol, glyceryl caprate, sorbitan caprylate, disodium glutamate Acid tetrasodium, ethylenediaminedisuccinate trisodium, lactic acid, sodium lactate, F Rambinon, xylitol caprylate, benzoic acid 3-hydroxypropyl ester, 3-Hydroxypropyl 2-hydroxybenzoate, 3-hydroxypropyl 2-hydroxybenzoate 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol , 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2 ,3-Pentanediol, 2,3-Hexanediol, 2,3-Heptanediol, 2, 3-octanediol, 2,3-nonanediol, 1,2-decanediol or the aforementioned a mixture of two or more antimicrobial components; or 1,2-pentanediol in combination with 2,3-heptanediol and the following antimicrobial One or more of the components: dehydroacetic acid, iodopropynyl butylcarbamate, saponin Licylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazo Lysinyl urea, diazolidinyl urea, farnesol, bisabolol, caprylic / glycerin phytate or phytic acid; sodium levulinate or levulinic acid acid and its esters and / or ketals, chlorhexidine, glycerin, laurate Seryl, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, Ethyl alcohol, glyceryl caprate, sorbitan caprylate, disodium glutamate Acid tetrasodium, ethylenediaminedisuccinate trisodium, lactic acid, sodium lactate, F Rambinon, xylitol caprylate, benzoic acid 3-hydroxypropyl ester, 3-Hydroxypropyl 2-hydroxybenzoate, 3-hydroxypropyl 2-hydroxybenzoate 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol , 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2 ,3-Pentanediol, 2,3-Hexanediol, 2,3-Heptanediol, 2, 3-octanediol, 2,3-nonanediol, 1,2-decanediol or the aforementioned a mixture of two or more antimicrobial components; or 1,2-pentanediol in combination with 2,3-octanediol and the following antimicrobial One or more of the components: dehydroacetic acid, iodopropynyl butylcarbamate, saponin Licylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazo Lysinyl urea, diazolidinyl urea, farnesol, bisabolol, caprylic / glycerin phytate or phytic acid; sodium levulinate or levulinic acid acid and its esters and / or ketals, chlorhexidine, glycerin, laurate Seryl, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, Ethyl alcohol, glyceryl caprate, sorbitan caprylate, disodium glutamate Acid tetrasodium, ethylenediaminedisuccinate trisodium, lactic acid, sodium lactate, F Rambinon, xylitol caprylate, benzoic acid 3-hydroxypropyl ester, 3-Hydroxypropyl 2-hydroxybenzoate, 3-hydroxypropyl 2-hydroxybenzoate 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol , 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2 ,3-Pentanediol, 2,3-Hexanediol, 2,3-Heptanediol, 2, 3-octanediol, 2,3-nonanediol, 1,2-decanediol or the aforementioned a mixture of two or more antimicrobial components; or 1,2-Pentanediol in combination with 1,2-nonanediol and the following antimicrobial One or more of the components: Dehydroacetic acid, iodopropynyl butylcarbamate, salicylic acid Citric acid, chlorphenesin, isobutylparaben, ethylparaben sodium, diazolidinyl Diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, caprylic / glyceryl stearate phytate or phytic acid; sodium levulinate or levulinate Acids and their esters and / or ketals, chlorhexidine, glycerin, lauric acid Anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenoxyethanol Netyl alcohol, glyceryl caprate, sorbitan caprylate, glutamic acid diacetate Tetrasodium, Trisodium Ethylenediamine Disuccinate, Lactic Acid, Sodium Lactate, Fr ambinon, xylitol caprylate, benzoic acid 3-hydroxypropyl ester, aniline benzoic acid 3-hydroxypropyl ester, 2-hydroxybenzoic acid 3-hydroxypropyl , 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2, 3-Pentanediol, 2,3-Hexanediol, 2,3-Heptanediol, 2,3 -octanediol, 2,3-nonanediol, 1,2-decanediol or any of the aforementioned a mixture of two or more microbial components; or 1,2-Pentanediol in combination with 2,3-nonanediol and the following antimicrobial One or more of the components: Dehydroacetic acid, iodopropynyl butylcarbamate, salicylic acid Citric acid, chlorphenesin, isobutylparaben, ethylparaben sodium, diazolidinyl Diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, caprylic / glyceryl stearate phytate or phytic acid; sodium levulinate or levulinate Acids and their esters and / or ketals, chlorhexidine, glycerin, lauric acid Anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenoxyethanol Netyl alcohol, glyceryl caprate, sorbitan caprylate, glutamic acid diacetate Tetrasodium, Trisodium Ethylenediamine Disuccinate, Lactic Acid, Sodium Lactate, Fr ambinon, xylitol caprylate, benzoic acid 3-hydroxypropyl ester, aniline benzoic acid 3-hydroxypropyl ester, 2-hydroxybenzoic acid 3-hydroxypropyl , 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2, 3-Pentanediol, 2,3-Hexanediol, 2,3-Heptanediol, 2,3 -octanediol, 2,3-nonanediol, 1,2-decanediol or any of the aforementioned a mixture of two or more microbial components; or 1,2-heptanediol in combination with 1,2-octanediol and the following antimicrobial One or more of the components: dehydroacetic acid, iodopropynyl butylcarbamate, saponin Licylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazo Lysinyl urea, diazolidinyl urea, farnesol, bisabolol, caprylic / glycerin phytate or phytic acid; sodium levulinate or levulinic acid acid and its esters and / or ketals, chlorhexidine, glycerin, laurate Seryl, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, Ethyl alcohol, glyceryl caprate, sorbitan caprylate, disodium glutamate Acid tetrasodium, ethylenediaminedisuccinate trisodium, lactic acid, sodium lactate, F Rambinon, xylitol caprylate, benzoic acid 3-hydroxypropyl ester, 3-Hydroxypropyl 2-hydroxybenzoate, 3-hydroxypropyl 2-hydroxybenzoate 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol , 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2 ,3-Pentanediol, 2,3-Hexanediol, 2,3-Heptanediol, 2, 3-octanediol, 2,3-nonanediol, 1,2-decanediol or the aforementioned a mixture of two or more antimicrobial components; or 1,2-heptanediol in combination with 2,3-octanediol and the following antimicrobial One or more of the components: dehydroacetic acid, iodopropynyl butylcarbamate, saponin Licylic acid, chlorphenesin, isobutylparaben, sodium ethylparaben, diazo Lysinyl urea, diazolidinyl urea, farnesol, bisabolol, caprylic / glycerin phytate or phytic acid; sodium levulinate or levulinic acid acid and its esters and / or ketals, chlorhexidine, glycerin, laurate Seryl, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, Ethyl alcohol, glyceryl caprate, sorbitan caprylate, disodium glutamate Acid tetrasodium, ethylenediaminedisuccinate trisodium, lactic acid, sodium lactate, F Rambinon, xylitol caprylate, benzoic acid 3-hydroxypropyl ester, 3-Hydroxypropyl 2-hydroxybenzoate, 3-hydroxypropyl 2-hydroxybenzoate 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol , 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2 ,3-Pentanediol, 2,3-Hexanediol, 2,3-Heptanediol, 2, 3-octanediol, 2,3-nonanediol, 1,2-decanediol or the aforementioned a mixture of two or more antimicrobial components; or 1,2-heptanediol in combination with 1,2-nonanediol and the following antimicrobial One or more of the components: Dehydroacetic acid, iodopropynyl butylcarbamate, salicylic acid Citric acid, chlorphenesin, isobutylparaben, ethylparaben sodium, diazolidinyl Diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, caprylic / glyceryl stearate phytate or phytic acid; sodium levulinate or levulinate Acids and their esters and / or ketals, chlorhexidine, glycerin, lauric acid Anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenoxyethanol Netyl alcohol, glyceryl caprate, sorbitan caprylate, glutamic acid diacetate Tetrasodium, Trisodium Ethylenediamine Disuccinate, Lactic Acid, Sodium Lactate, Fr ambinon, xylitol caprylate, benzoic acid 3-hydroxypropyl ester, aniline benzoic acid 3-hydroxypropyl ester, 2-hydroxybenzoic acid 3-hydroxypropyl , 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2, 3-Pentanediol, 2,3-Hexanediol, 2,3-Heptanediol, 2,3 -octanediol, 2,3-nonanediol, 1,2-decanediol or any of the aforementioned a mixture of two or more microbial components; or 1,2-heptanediol in combination with 2,3-nonanediol and the following antimicrobial One or more of the components: Dehydroacetic acid, iodopropynyl butylcarbamate, salicylic acid Citric acid, chlorphenesin, isobutylparaben, ethylparaben sodium, diazolidinyl Diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, caprylic / glyceryl stearate phytate or phytic acid; sodium levulinate or levulinate Acids and their esters and / or ketals, chlorhexidine, glycerin, lauric acid Anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenoxyethanol Netyl alcohol, glyceryl caprate, sorbitan caprylate, glutamic acid diacetate Tetrasodium, Trisodium Ethylenediamine Disuccinate, Lactic Acid, Sodium Lactate, Fr ambinon, xylitol caprylate, benzoic acid 3-hydroxypropyl ester, aniline benzoic acid 3-hydroxypropyl ester, 2-hydroxybenzoic acid 3-hydroxypropyl , 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2, 3-Pentanediol, 2,3-Hexanediol, 2,3-Heptanediol, 2,3 -octanediol, 2,3-nonanediol, 1,2-decanediol or any of the aforementioned A mixture of two or more microbial components.

[0221] Components (a) and (b) in the composition according to the first or second aspect of the present invention ) are the following: 1,2-pentanediol and one or more of the following antimicrobial components: phenoxyethanol Ethanol, EDTA disodium, methylparaben, sodium benzoate, benzyl alcohol Alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben Methylchloroisothiazolinone, Methylisothiazolinone, Ethylhexylglycerin Paraben, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin hydroxyethoxyphenyl butanone, hydroxyethoxyphenyl butanol, Itaconic Acid, Octirox, Propanediol Caprylate, Climbazole, 4- Hydroxyacetophenone, Frambinon, Xylityl Caprylate, 3-benzoate Anisic acid 3-hydroxypropyl ester, 2-hydroxy 3-Hydroxypropyl benzoate, 1,3-propanediol, 1,2-pentanediol 1,2-Hexanediol, 1,2-Heptanediol, 1,2-Octanediol , 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2 ,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2 -decanediol or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-Hexanediol and one or more of the following antimicrobial components: phenoxyethanol Ethanol, EDTA disodium, methylparaben, sodium benzoate, benzyl alcohol Alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben Methylchloroisothiazolinone, Methylisothiazolinone, Ethylhexylglycerin Paraben, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin hydroxyethoxyphenyl butanone, hydroxyethoxyphenyl butanol, Itaconic Acid, Octirox, Propanediol Caprylate, Climbazole, 4- Hydroxyacetophenone, Frambinon, Xylityl Caprylate, 3-benzoate Anisic acid 3-hydroxypropyl ester, 2-hydroxy 3-Hydroxypropyl benzoate, 1,3-propanediol, 1,2-pentanediol 1,2-Hexanediol, 1,2-Heptanediol, 1,2-Octanediol , 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2 ,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2 -decanediol or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-heptanediol and one or more of the following antimicrobial components: phenoxyethanol Ethanol, EDTA disodium, methylparaben, sodium benzoate, benzyl alcohol Alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben Methylchloroisothiazolinone, Methylisothiazolinone, Ethylhexylglycerin Paraben, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin hydroxyethoxyphenyl butanone, hydroxyethoxyphenyl butanol, Itaconic Acid, Octirox, Propanediol Caprylate, Climbazole, 4- Hydroxyacetophenone, Frambinon, Xylityl Caprylate, 3-benzoate Anisic acid 3-hydroxypropyl ester, 2-hydroxy 3-Hydroxypropyl benzoate, 1,3-propanediol, 1,2-pentanediol 1,2-Hexanediol, 1,2-Heptanediol, 1,2-Octanediol , 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2 ,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2 -decanediol or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-octanediol and one or more of the following antimicrobial components: phenoxyethanol Ethanol, EDTA disodium, methylparaben, sodium benzoate, benzyl alcohol Alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben Methylchloroisothiazolinone, Methylisothiazolinone, Ethylhexylglycerin Paraben, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin hydroxyethoxyphenyl butanone, hydroxyethoxyphenyl butanol, Itaconic Acid, Octirox, Propanediol Caprylate, Climbazole, 4- Hydroxyacetophenone, Frambinon, Xylityl Caprylate, 3-benzoate Anisic acid 3-hydroxypropyl ester, 2-hydroxy 3-Hydroxypropyl benzoate, 1,3-propanediol, 1,2-pentanediol 1,2-Hexanediol, 1,2-Heptanediol, 1,2-Octanediol , 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2 ,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2 -decanediol or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-nonanediol and one or more of the following antimicrobial components: phenoxyethanol Alcohol, EDTA disodium, methylparaben, sodium benzoate, benzyl alcohol Cole, potassium sorbate, benzyl salicylate, propylparaben, methylparaben , methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin , butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin Hydroxyethoxyphenylbutanone, Hydroxyethoxyphenylbutanol, Octaconic Acid, Octirox, Propanediol Caprylate, Climbazole, 4-Hydroxyethylpropional Hydroxyacetophenone, Frambion, Xylitol Caprylate, 3-Hydroxybenzoate Anisic acid 3-hydroxypropyl ester, 2-hydroxybenzoic acid 3-Hydroxypropylbenzoate, 1,3-propanediol, 1,2-pentanediol , 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2, 3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2- Decanediol or a mixture of two or more of the foregoing antimicrobial components; or 1,2-Decanediol and one or more of the following antimicrobial components: phenoxyethanol Alcohol, EDTA disodium, methylparaben, sodium benzoate, benzyl alcohol Cole, potassium sorbate, benzyl salicylate, propylparaben, methylparaben , methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin , butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin Hydroxyethoxyphenylbutanone, Hydroxyethoxyphenylbutanol, Octaconic Acid, Octirox, Propanediol Caprylate, Climbazole, 4-Hydroxyethylpropional Hydroxyacetophenone, Frambion, Xylitol Caprylate, 3-Hydroxybenzoate Anisic acid 3-hydroxypropyl ester, 2-hydroxybenzoic acid 3-Hydroxypropylbenzoate, 1,3-propanediol, 1,2-pentanediol , 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2, 3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2- Decanediol or a mixture of two or more of the foregoing antimicrobial components; or 1,2-undecanediol and one or more of the following antimicrobial components: Citric acid, disodium EDTA, methylparaben, sodium benzoate, benzyl Alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben Ben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin Phosphorus, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin Hydroxyethoxyphenylbutanone, Hydroxyethoxyphenylbutanol , Itaconic Acid, Octirox, Propanediol Caprylate, Climbazole, 4 -Hydroxyacetophenone, Frambinone, Xylityl Caprylate, Benzoic Acid 3 -hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 2-hydroxy 3-Hydroxypropyl benzoate, 1,3-propanediol, 1,2-pentanedioic acid 1,2-Hexanediol, 1,2-Heptanediol, 1,2-Octanediol 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1, 2-decanediol or a mixture of two or more of the foregoing antimicrobial components; or 1,2-dodecanediol and one or more of the following antimicrobial components: phenoxyethanol Ethanol, EDTA disodium, methylparaben, sodium benzoate, benzyl alcohol Alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben Methylchloroisothiazolinone, Methylisothiazolinone, Ethylhexylglycerin Paraben, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin hydroxyethoxyphenyl butanone, hydroxyethoxyphenyl butanol, Itaconic Acid, Octirox, Propanediol Caprylate, Climbazole, 4- Hydroxyacetophenone, Frambinon, Xylityl Caprylate, 3-benzoate Anisic acid 3-hydroxypropyl ester, 2-hydroxy 3-Hydroxypropyl benzoate, 1,3-propanediol, 1,2-pentanediol 1,2-Hexanediol, 1,2-Heptanediol, 1,2-Octanediol , 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2 ,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2 -decanediol or a mixture of two or more of the aforementioned antimicrobial components; or 1,2-tridecanediol and one or more of the following antimicrobial components: phenoxyethanol Citric acid, disodium EDTA, methylparaben, sodium benzoate, benzyl Alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben Ben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin Phosphorus, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin Hydroxyethoxyphenylbutanone, Hydroxyethoxyphenylbutanol , Itaconic Acid, Octirox, Propanediol Caprylate, Climbazole, 4 -Hydroxyacetophenone, Frambinone, Xylityl Caprylate, Benzoic Acid 3 -hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 2-hydroxy 3-Hydroxypropyl benzoate, 1,3-propanediol, 1,2-pentanedioic acid 1,2-Hexanediol, 1,2-Heptanediol, 1,2-Octanediol 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1, 2-decanediol or a mixture of two or more of the foregoing antimicrobial components; or 2,3-pentanediol and one or more of the following antimicrobial components: phenoxyethanol Ethanol, EDTA disodium, methylparaben, sodium benzoate, benzyl alcohol Alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben Methylchloroisothiazolinone, Methylisothiazolinone, Ethylhexylglycerin Paraben, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin hydroxyethoxyphenyl butanone, hydroxyethoxyphenyl butanol, Itaconic Acid, Octirox, Propanediol Caprylate, Climbazole, 4- Hydroxyacetophenone, Frambinon, Xylityl Caprylate, 3-benzoate Anisic acid 3-hydroxypropyl ester, 2-hydroxy 3-Hydroxypropyl benzoate, 1,3-propanediol, 1,2-pentanediol 1,2-Hexanediol, 1,2-Heptanediol, 1,2-Octanediol , 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2 ,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2 -decanediol or a mixture of two or more of the aforementioned antimicrobial components; or 2,3-Hexanediol and one or more of the following antimicrobial components: phenoxyethanol Ethanol, EDTA disodium, methylparaben, sodium benzoate, benzyl alcohol Alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben Methylchloroisothiazolinone, Methylisothiazolinone, Ethylhexylglycerin Paraben, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin hydroxyethoxyphenyl butanone, hydroxyethoxyphenyl butanol, Itaconic Acid, Octirox, Propanediol Caprylate, Climbazole, 4- Hydroxyacetophenone, Frambinon, Xylityl Caprylate, 3-benzoate Anisic acid 3-hydroxypropyl ester, 2-hydroxy 3-Hydroxypropyl benzoate, 1,3-propanediol, 1,2-pentanediol 1,2-Hexanediol, 1,2-Heptanediol, 1,2-Octanediol , 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2 ,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2 -decanediol or a mixture of two or more of the aforementioned antimicrobial components; or 2,3-heptanediol and one or more of the following antimicrobial components: phenoxyethanol Ethanol, EDTA disodium, methylparaben, sodium benzoate, benzyl alcohol Alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben Methylchloroisothiazolinone, Methylisothiazolinone, Ethylhexylglycerin Paraben, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin hydroxyethoxyphenyl butanone, hydroxyethoxyphenyl butanol, Itaconic Acid, Octirox, Propanediol Caprylate, Climbazole, 4- Hydroxyacetophenone, Frambinon, Xylityl Caprylate, 3-benzoate Anisic acid 3-hydroxypropyl ester, 2-hydroxy 3-Hydroxypropyl benzoate, 1,3-propanediol, 1,2-pentanediol 1,2-Hexanediol, 1,2-Heptanediol, 1,2-Octanediol , 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2 ,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2 -decanediol or a mixture of two or more of the aforementioned antimicrobial components; or 2,3-octanediol and one or more of the following antimicrobial components: phenoxyethanol Ethanol, EDTA disodium, methylparaben, sodium benzoate, benzyl alcohol Alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben Methylchloroisothiazolinone, Methylisothiazolinone, Ethylhexylglycerin Paraben, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin hydroxyethoxyphenyl butanone, hydroxyethoxyphenyl butanol, Itaconic Acid, Octirox, Propanediol Caprylate, Climbazole, 4- Hydroxyacetophenone, Frambinon, Xylityl Caprylate, 3-benzoate Anisic acid 3-hydroxypropyl ester, 2-hydroxy 3-Hydroxypropyl benzoate, 1,3-propanediol, 1,2-pentanediol 1,2-Hexanediol, 1,2-Heptanediol, 1,2-Octanediol , 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2 ,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2 -decanediol or a mixture of two or more of the aforementioned antimicrobial components; or 2,3-nonanediol and one or more of the following antimicrobial components: phenoxyethanol Alcohol, EDTA disodium, methylparaben, sodium benzoate, benzyl alcohol Cole, potassium sorbate, benzyl salicylate, propylparaben, methylparaben , methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin , butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin Hydroxyethoxyphenylbutanone, Hydroxyethoxyphenylbutanol, Octaconic Acid, Octirox, Propanediol Caprylate, Climbazole, 4-Hydroxyethylpropional Hydroxyacetophenone, Frambion, Xylitol Caprylate, 3-Hydroxybenzoate Anisic acid 3-hydroxypropyl ester, 2-hydroxybenzoic acid 3-Hydroxypropylbenzoate, 1,3-propanediol, 1,2-pentanediol , 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2, 3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2- Decanediol or a mixture of two or more of the foregoing antimicrobial components; or 2,3-Decanediol and one or more of the following antimicrobial components: phenoxyethanol Alcohol, EDTA disodium, methylparaben, sodium benzoate, benzyl alcohol Cole, potassium sorbate, benzyl salicylate, propylparaben, methylparaben , methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin , butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin Hydroxyethoxyphenylbutanone, Hydroxyethoxyphenylbutanol, Octaconic Acid, Octirox, Propanediol Caprylate, Climbazole, 4-Hydroxyethylpropional Hydroxyacetophenone, Frambion, Xylitol Caprylate, 3-Hydroxybenzoate Anisic acid 3-hydroxypropyl ester, 2-hydroxybenzoic acid 3-Hydroxypropylbenzoate, 1,3-propanediol, 1,2-pentanediol , 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2, 3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2- Decanediol or a mixture of two or more of the foregoing antimicrobial components; or 2,3-undecanediol and one or more of the following antimicrobial components: Citric acid, disodium EDTA, methylparaben, sodium benzoate, benzyl Alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben Ben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin Phosphorus, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin Hydroxyethoxyphenylbutanone, Hydroxyethoxyphenylbutanol , Itaconic Acid, Octirox, Propanediol Caprylate, Climbazole, 4 -Hydroxyacetophenone, Frambinone, Xylityl Caprylate, Benzoic Acid 3 -hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 2-hydroxy 3-Hydroxypropyl benzoate, 1,3-propanediol, 1,2-pentanedioic acid 1,2-Hexanediol, 1,2-Heptanediol, 1,2-Octanediol 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1, 2-decanediol or a mixture of two or more of the foregoing antimicrobial components; or 2,3-dodecanediol and one or more of the following antimicrobial components: phenoxyethanol Ethanol, EDTA disodium, methylparaben, sodium benzoate, benzyl alcohol Alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben Methylchloroisothiazolinone, Methylisothiazolinone, Ethylhexylglycerin Paraben, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin hydroxyethoxyphenyl butanone, hydroxyethoxyphenyl butanol, Itaconic Acid, Octirox, Propanediol Caprylate, Climbazole, 4- Hydroxyacetophenone, Frambinon, Xylityl Caprylate, 3-benzoate Anisic acid 3-hydroxypropyl ester, 2-hydroxy 3-Hydroxypropyl benzoate, 1,3-propanediol, 1,2-pentanediol 1,2-Hexanediol, 1,2-Heptanediol, 1,2-Octanediol , 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2 ,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1,2 -decanediol or a mixture of two or more of the aforementioned antimicrobial components; or 2,3-tridecanediol and one or more of the following antimicrobial components: Citric acid, disodium EDTA, methylparaben, sodium benzoate, benzyl Alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylparaben Ben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin Phosphorus, butylparaben, ethylparaben, sodium propylparaben, DMDM ​​hydantoin Hydroxyethoxyphenylbutanone, Hydroxyethoxyphenylbutanol , Itaconic Acid, Octirox, Propanediol Caprylate, Climbazole, 4 -Hydroxyacetophenone, Frambinone, Xylityl Caprylate, Benzoic Acid 3 -hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 2-hydroxy 3-Hydroxypropyl benzoate, 1,3-propanediol, 1,2-pentanedioic acid 1,2-Hexanediol, 1,2-Heptanediol, 1,2-Octanediol 1,2-nonanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 1, 2-decanediol or a mixture of two or more of the foregoing antimicrobial components; or 1,2-pentanediol in combination with 2,3-pentanediol and the following antimicrobial One or more of the ingredients: phenoxyethanol, disodium EDTA, methyl paraben Laven, sodium benzoate, benzyl alcohol, potassium sorbate, salicylic acid benzyl, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone Sothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, propyl Sodium paraben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, Hydroxyethoxyphenylbutanol, Itaconic Acid, Octopirox, Caprylic Acid Propanediol, Climbazole, 4-Hydroxyacetophenone, Frambino n, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl hydroxypropyl ester, 2-hydroxybenzoic acid 3-hydroxypropyl ester, 1,3-propyl ester propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol Tandiol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentane Diols, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol ol, 2,3-nonanediol, 1,2-decanediol or the aforementioned antimicrobial compositions a mixture of two or more of the ingredients; or 1,2-Hexanediol in combination with 2,3-Hexanediol and the following antimicrobial One or more of the ingredients: phenoxyethanol, disodium EDTA, methyl paraben Laven, sodium benzoate, benzyl alcohol, potassium sorbate, salicylic acid benzyl, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone Sothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, propyl Sodium paraben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, Hydroxyethoxyphenylbutanol, Itaconic Acid, Octopirox, Caprylic Acid Propanediol, Climbazole, 4-Hydroxyacetophenone, Frambino n, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl hydroxypropyl ester, 2-hydroxybenzoic acid 3-hydroxypropyl ester, 1,3-propyl ester propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol Tandiol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentane Diols, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol ol, 2,3-nonanediol, 1,2-decanediol or the aforementioned antimicrobial compositions a mixture of two or more of the ingredients; or 1,2-heptanediol in combination with 2,3-heptanediol and the following antimicrobial One or more of the ingredients: phenoxyethanol, disodium EDTA, methyl paraben Laven, sodium benzoate, benzyl alcohol, potassium sorbate, salicylic acid benzyl, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone Sothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, propyl Sodium paraben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, Hydroxyethoxyphenylbutanol, Itaconic Acid, Octopirox, Caprylic Acid Propanediol, Climbazole, 4-Hydroxyacetophenone, Frambino n, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl hydroxypropyl ester, 2-hydroxybenzoic acid 3-hydroxypropyl ester, 1,3-propyl ester propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol Tandiol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentane Diols, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol ol, 2,3-nonanediol, 1,2-decanediol or the aforementioned antimicrobial compositions a mixture of two or more of the ingredients; or 1,2-octanediol in combination with 2,3-octanediol and the following antimicrobial One or more of the ingredients: phenoxyethanol, disodium EDTA, methyl paraben Laven, sodium benzoate, benzyl alcohol, potassium sorbate, salicylic acid benzyl, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone Sothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, propyl Sodium paraben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, Hydroxyethoxyphenylbutanol, Itaconic Acid, Octopirox, Caprylic Acid Propanediol, Climbazole, 4-Hydroxyacetophenone, Frambino n, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl hydroxypropyl ester, 2-hydroxybenzoic acid 3-hydroxypropyl ester, 1,3-propyl ester propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol Tandiol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentane Diols, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol ol, 2,3-nonanediol, 1,2-decanediol or the aforementioned antimicrobial compositions a mixture of two or more of the ingredients; or 1,2-nonanediol in combination with 2,3-nonanediol and the following antimicrobial structures: Ingredients: Phenoxyethanol, Disodium EDTA, Methylparaben Benzyl alcohol, potassium sorbate, benzoic acid, benzoyl salicylate Propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone Azolinone, ethylhexylglycerin, butylparaben, ethylparaben, propylparaben Laven sodium, DMDM ​​hydantoin, hydroxyethoxyphenyl butanone, hydroxy Ethoxyphenylbutanol, Itaconic Acid, Octopirox, Propylene Glycol, Caprylic Acid Pandiol, Climbazole, 4-hydroxyacetophenone, Frambion, Xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl 3-Hydroxypropyl ester, 2-hydroxybenzoate, 1,3-propanol 1,2-pentanediol, 1,2-hexanediol, 1,2-heptane Diol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanedio 2,3-Hexanediol, 2,3-Heptanediol, 2,3-Octanediol 2,3-nonanediol or a mixture of two or more of the foregoing antimicrobial components; 2-decanediol, or 1,2-decanediol in combination with 2,3-decanediol and the following antimicrobial structures: Ingredients: Phenoxyethanol, Disodium EDTA, Methylparaben Benzyl alcohol, potassium sorbate, benzoic acid, benzoyl salicylate Propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone Azolinone, ethylhexylglycerin, butylparaben, ethylparaben, propylparaben Laven sodium, DMDM ​​hydantoin, hydroxyethoxyphenyl butanone, hydroxy Ethoxyphenylbutanol, Itaconic Acid, Octopirox, Propylene Glycol, Caprylic Acid Pandiol, Climbazole, 4-hydroxyacetophenone, Frambion, Xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl 3-Hydroxypropyl ester, 2-hydroxybenzoate, 1,3-propanol 1,2-pentanediol, 1,2-hexanediol, 1,2-heptane Diol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanedio 2,3-Hexanediol, 2,3-Heptanediol, 2,3-Octanediol 2,3-nonanediol or a mixture of two or more of the foregoing antimicrobial components; 2-decanediol, or 1,2-undecanediol in combination with 2,3-undecanediol and the following anti- One or more of the microbial components: phenoxyethanol, disodium EDTA, methyl Paraben, sodium benzoate, benzyl alcohol, potassium sorbate, salicylic acid Benzyl paraben, propylparaben, methylparaben, methylchloroisothiazolinone, methyl Isothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, propanediol Propylparaben sodium, DMDM ​​hydantoin, hydroxyethoxyphenyl butanolate Hydroxyethoxyphenylbutanol, Itaconic Acid, Octopirox, Caprylic / Capric Triglyceride Propanediol, Climbazole, 4-Hydroxyacetophenone, Framb Non, Xylitol Caprylate, Benzoic Acid 3-Hydroxypropyl Ester, Anisic Acid 3- Hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3 -propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2- Heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol Tandanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol 2,3-nonanediol, 2,3-nonanediol or a mixture of two or more of the aforementioned antimicrobial components 1,2-decanediol, or 1,2-dodecanediol in combination with 2,3-dodecanediol and the following antimicrobial One or more of the ingredients: phenoxyethanol, disodium EDTA, methyl paraben Laven, sodium benzoate, benzyl alcohol, potassium sorbate, salicylic acid benzyl, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone Sothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, propyl Sodium paraben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, Hydroxyethoxyphenylbutanol, Itaconic Acid, Octopirox, Caprylic Acid Propanediol, Climbazole, 4-Hydroxyacetophenone, Frambino n, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl hydroxypropyl ester, 2-hydroxybenzoic acid 3-hydroxypropyl ester, 1,3-propyl ester propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol Tandiol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentane Diols, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol ol, 2,3-nonanediol, 1,2-decanediol or the aforementioned antimicrobial compositions a mixture of two or more of the ingredients; or 1,2-tridecanediol in combination with 2,3-tridecanediol and the following anti- One or more of the microbial components: phenoxyethanol, disodium EDTA, methyl Paraben, sodium benzoate, benzyl alcohol, potassium sorbate, salicylic acid Benzyl paraben, propylparaben, methylparaben, methylchloroisothiazolinone, methyl Isothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, propanediol Propylparaben sodium, DMDM ​​hydantoin, hydroxyethoxyphenyl butanolate Hydroxyethoxyphenylbutanol, Itaconic Acid, Octopirox, Caprylic / Capric Triglyceride Propanediol, Climbazole, 4-Hydroxyacetophenone, Framb Non, Xylitol Caprylate, Benzoic Acid 3-Hydroxypropyl Ester, Anisic Acid 3- Hydroxypropyl ester, 3-hydroxypropyl 2-hydroxybenzoate, 1,3 -propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2- Heptanediol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol Tandanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol 2,3-nonanediol, 1,2-decanediol or the aforementioned antimicrobials a mixture of two or more of the components; or 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2 -undecanediol, 1,2-dodecanediol or 1,2-tridecanediol 1,2-heptanediol in combination with one or more of the following antimicrobial components: One or more of: Phenoxyethanol, Disodium EDTA, Methylparaben, Benzoic acid Sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, pro Pilparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone , ethylhexylglycerin, butylparaben, ethylparaben, propylparaben thorium, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanone Toxophenylbutanol, Itaconic Acid, Octopirox, Propanedioic Acid Climbazole, 4-hydroxyacetophenone, Frambion, Capryl Xylitol, Benzoic acid 3-hydroxypropyl ester, Anisic acid 3-hydroxypropyl ester, 2-hydroxybenzoic acid 3-hydroxypropyl, 1,3-propanediol 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol , 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2 ,3-Hexanediol, 2,3-Heptanediol, 2,3-Octanediol, 2, 3-nonanediol, 1,2-decanediol or two or more of the aforementioned antimicrobial components a mixture of the above; or 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3 -undecanediol, 2,3-dodecanediol or 2,3-tridecanediol 1,2-heptanediol in combination with one or more of the following antimicrobial components: One or more of: Phenoxyethanol, Disodium EDTA, Methylparaben, Benzoic acid Sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, pro Pilparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone , ethylhexylglycerin, butylparaben, ethylparaben, propylparaben thorium, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanone Toxophenylbutanol, Itaconic Acid, Octopirox, Propanedioic Acid Climbazole, 4-hydroxyacetophenone, Frambion, Capryl Xylitol, Benzoic acid 3-hydroxypropyl ester, Anisic acid 3-hydroxypropyl ester, 2-hydroxybenzoic acid 3-hydroxypropyl, 1,3-propanediol 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol , 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol, 2 ,3-Hexanediol, 2,3-Heptanediol, 2,3-Octanediol, 2, 3-nonanediol, 1,2-decanediol or two or more of the aforementioned antimicrobial components a mixture of the above; or 1,2-Hexanediol in combination with 2,3-Octanediol and the following antimicrobial One or more of the ingredients: phenoxyethanol, disodium EDTA, methyl paraben Laven, sodium benzoate, benzyl alcohol, potassium sorbate, salicylic acid benzyl, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone Sothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, propyl Sodium paraben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, Hydroxyethoxyphenylbutanol, Itaconic Acid, Octopirox, Caprylic Acid Propanediol, Climbazole, 4-Hydroxyacetophenone, Frambino n, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl hydroxypropyl ester, 2-hydroxybenzoic acid 3-hydroxypropyl ester, 1,3-propyl ester propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol Tandiol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentane Diols, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol ol, 2,3-nonanediol, 1,2-decanediol or the aforementioned antimicrobial compositions a mixture of two or more of the ingredients; or 1,2-octanediol in combination with 2,3-hexanediol and the following antimicrobial One or more of the ingredients: phenoxyethanol, disodium EDTA, methyl paraben Laven, sodium benzoate, benzyl alcohol, potassium sorbate, salicylic acid benzyl, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone Sothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, propyl Sodium paraben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, Hydroxyethoxyphenylbutanol, Itaconic Acid, Octopirox, Caprylic Acid Propanediol, Climbazole, 4-Hydroxyacetophenone, Frambino n, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl hydroxypropyl ester, 2-hydroxybenzoic acid 3-hydroxypropyl ester, 1,3-propyl ester propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol Tandiol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentane Diols, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol ol, 2,3-nonanediol, 1,2-decanediol or the aforementioned antimicrobial compositions a mixture of two or more of the ingredients; or 1,2-octanediol in combination with 2,3-heptanediol and the following antimicrobial One or more of the ingredients: phenoxyethanol, disodium EDTA, methyl paraben Laven, sodium benzoate, benzyl alcohol, potassium sorbate, salicylic acid benzyl, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone Sothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, propyl Sodium paraben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, Hydroxyethoxyphenylbutanol, Itaconic Acid, Octopirox, Caprylic Acid Propanediol, Climbazole, 4-Hydroxyacetophenone, Frambino n, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl hydroxypropyl ester, 2-hydroxybenzoic acid 3-hydroxypropyl ester, 1,3-propyl ester propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol Tandiol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentane Diols, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol ol, 2,3-nonanediol, 1,2-decanediol or the aforementioned antimicrobial compositions a mixture of two or more of the ingredients; or 1,2-pentanediol in combination with 2,3-hexanediol and the following antimicrobial One or more of the ingredients: phenoxyethanol, disodium EDTA, methyl paraben Laven, sodium benzoate, benzyl alcohol, potassium sorbate, salicylic acid benzyl, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone Sothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, propyl Sodium paraben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, Hydroxyethoxyphenylbutanol, Itaconic Acid, Octopirox, Caprylic Acid Propanediol, Climbazole, 4-Hydroxyacetophenone, Frambino n, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl hydroxypropyl ester, 2-hydroxybenzoic acid 3-hydroxypropyl ester, 1,3-propyl ester propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol Tandiol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentane Diols, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol ol, 2,3-nonanediol, 1,2-decanediol or the aforementioned antimicrobial compositions a mixture of two or more of the ingredients; or 1,2-pentanediol in combination with 1,2-heptanediol and the following antimicrobial One or more of the ingredients: phenoxyethanol, disodium EDTA, methyl paraben Laven, sodium benzoate, benzyl alcohol, potassium sorbate, salicylic acid benzyl, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone Sothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, propyl Sodium paraben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, Hydroxyethoxyphenylbutanol, Itaconic Acid, Octopirox, Caprylic Acid Propanediol, Climbazole, 4-Hydroxyacetophenone, Frambino n, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl hydroxypropyl ester, 2-hydroxybenzoic acid 3-hydroxypropyl ester, 1,3-propyl ester propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol Tandiol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentane Diols, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol ol, 2,3-nonanediol, 1,2-decanediol or the aforementioned antimicrobial compositions a mixture of two or more of the ingredients; or 1,2-pentanediol in combination with 2,3-heptanediol and the following antimicrobial One or more of the ingredients: phenoxyethanol, disodium EDTA, methyl paraben Laven, sodium benzoate, benzyl alcohol, potassium sorbate, salicylic acid benzyl, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone Sothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, propyl Sodium paraben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, Hydroxyethoxyphenylbutanol, Itaconic Acid, Octopirox, Caprylic Acid Propanediol, Climbazole, 4-Hydroxyacetophenone, Frambino n, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl hydroxypropyl ester, 2-hydroxybenzoic acid 3-hydroxypropyl ester, 1,3-propyl ester propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol Tandiol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentane Diols, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol ol, 2,3-nonanediol, 1,2-decanediol or the aforementioned antimicrobial compositions a mixture of two or more of the ingredients; or 1,2-pentanediol in combination with 2,3-octanediol and the following antimicrobial One or more of the ingredients: phenoxyethanol, disodium EDTA, methyl paraben Laven, sodium benzoate, benzyl alcohol, potassium sorbate, salicylic acid benzyl, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone Sothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, propyl Sodium paraben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, Hydroxyethoxyphenylbutanol, Itaconic Acid, Octopirox, Caprylic Acid Propanediol, Climbazole, 4-Hydroxyacetophenone, Frambino n, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl hydroxypropyl ester, 2-hydroxybenzoic acid 3-hydroxypropyl ester, 1,3-propyl ester propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol Tandiol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentane Diols, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol ol, 2,3-nonanediol, 1,2-decanediol or the aforementioned antimicrobial compositions a mixture of two or more of the ingredients; or 1,2-Pentanediol in combination with 1,2-nonanediol and the following antimicrobial One or more of the ingredients: Phenoxyethanol, Disodium EDTA, Methylparaben Benzoate, sodium benzoate, benzyl alcohol, potassium sorbate, salicylate Dimethylparaben, Propylparaben, Methylparaben, Methylchloroisothiazolinone, Methyliso Thiazolinone, Ethylhexylglycerin, Butylparaben, Ethylparaben, Propyl Sodium paraben, DMDM ​​hydantoin, hydroxyethoxyphenyl butanone, hydantoin Hydroxyethoxyphenylbutanol, Itaconic Acid, Octopirox, Caprylic Acid Propanediol, Climbazole, 4-hydroxyacetophenone, Frambion , Xylitol Caprylate, Benzoic Acid 3-Hydroxypropyl Ester, Anisic Acid 3-Hydroxypropyl Ester hydroxypropyl ester, 2-hydroxybenzoic acid 3-hydroxypropyl, 1,3-propanol Pandiol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol 2,3-nonanediol, 1,2-decanediol or the aforementioned antimicrobial components a mixture of two or more of the following: 1,2-Pentanediol in combination with 2,3-nonanediol and the following antimicrobial One or more of the ingredients: Phenoxyethanol, Disodium EDTA, Methylparaben Benzoate, sodium benzoate, benzyl alcohol, potassium sorbate, salicylate Dimethylparaben, Propylparaben, Methylparaben, Methylchloroisothiazolinone, Methyliso Thiazolinone, Ethylhexylglycerin, Butylparaben, Ethylparaben, Propyl Sodium paraben, DMDM ​​hydantoin, hydroxyethoxyphenyl butanone, hydantoin Hydroxyethoxyphenylbutanol, Itaconic Acid, Octopirox, Caprylic Acid Propanediol, Climbazole, 4-hydroxyacetophenone, Frambion , Xylitol Caprylate, Benzoic Acid 3-Hydroxypropyl Ester, Anisic Acid 3-Hydroxypropyl Ester hydroxypropyl ester, 2-hydroxybenzoic acid 3-hydroxypropyl, 1,3-propanol Pandiol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol 2,3-nonanediol, 1,2-decanediol or the aforementioned antimicrobial components a mixture of two or more of the following: 1,2-heptanediol in combination with 1,2-octanediol and the following antimicrobial One or more of the ingredients: phenoxyethanol, disodium EDTA, methyl paraben Laven, sodium benzoate, benzyl alcohol, potassium sorbate, salicylic acid benzyl, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone Sothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, propyl Sodium paraben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, Hydroxyethoxyphenylbutanol, Itaconic Acid, Octopirox, Caprylic Acid Propanediol, Climbazole, 4-Hydroxyacetophenone, Frambino n, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl hydroxypropyl ester, 2-hydroxybenzoic acid 3-hydroxypropyl ester, 1,3-propyl ester propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol Tandiol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentane Diols, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol ol, 2,3-nonanediol, 1,2-decanediol or the aforementioned antimicrobial compositions a mixture of two or more of the ingredients; or 1,2-heptanediol in combination with 2,3-octanediol and the following antimicrobial One or more of the ingredients: phenoxyethanol, disodium EDTA, methyl paraben Laven, sodium benzoate, benzyl alcohol, potassium sorbate, salicylic acid benzyl, propylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone Sothiazolinone, ethylhexylglycerin, butylparaben, ethylparaben, propyl Sodium paraben, DMDM ​​hydantoin, hydroxyethoxyphenylbutanone, Hydroxyethoxyphenylbutanol, Itaconic Acid, Octopirox, Caprylic Acid Propanediol, Climbazole, 4-Hydroxyacetophenone, Frambino n, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl hydroxypropyl ester, 2-hydroxybenzoic acid 3-hydroxypropyl ester, 1,3-propyl ester propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol Tandiol, 1,2-octanediol, 1,2-nonanediol, 2,3-pentane Diols, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol ol, 2,3-nonanediol, 1,2-decanediol or the aforementioned antimicrobial compositions a mixture of two or more of the ingredients; or 1,2-heptanediol in combination with 1,2-nonanediol and the following antimicrobial One or more of the ingredients: Phenoxyethanol, Disodium EDTA, Methylparaben Benzoate, sodium benzoate, benzyl alcohol, potassium sorbate, salicylate Dimethylparaben, Propylparaben, Methylparaben, Methylchloroisothiazolinone, Methyliso Thiazolinone, Ethylhexylglycerin, Butylparaben, Ethylparaben, Propyl Sodium paraben, DMDM ​​hydantoin, hydroxyethoxyphenyl butanone, hydantoin Hydroxyethoxyphenylbutanol, Itaconic Acid, Octopirox, Caprylic Acid Propanediol, Climbazole, 4-hydroxyacetophenone, Frambion , Xylitol Caprylate, Benzoic Acid 3-Hydroxypropyl Ester, Anisic Acid 3-Hydroxypropyl Ester hydroxypropyl ester, 2-hydroxybenzoic acid 3-hydroxypropyl, 1,3-propanol Pandiol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol 2,3-nonanediol, 1,2-decanediol or the aforementioned antimicrobial components a mixture of two or more of the following: 1,2-heptanediol in combination with 2,3-nonanediol and the following antimicrobial One or more of the ingredients: Phenoxyethanol, Disodium EDTA, Methylparaben Benzoate, sodium benzoate, benzyl alcohol, potassium sorbate, salicylate Dimethylparaben, Propylparaben, Methylparaben, Methylchloroisothiazolinone, Methyliso Thiazolinone, Ethylhexylglycerin, Butylparaben, Ethylparaben, Propyl Sodium paraben, DMDM ​​hydantoin, hydroxyethoxyphenyl butanone, hydantoin Hydroxyethoxyphenylbutanol, Itaconic Acid, Octopirox, Caprylic Acid Propanediol, Climbazole, 4-hydroxyacetophenone, Frambion , Xylitol Caprylate, Benzoic Acid 3-Hydroxypropyl Ester, Anisic Acid 3-Hydroxypropyl Ester hydroxypropyl ester, 2-hydroxybenzoic acid 3-hydroxypropyl, 1,3-propanol Pandiol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol 1,2-octanediol, 1,2-nonanediol, 2,3-pentanediol 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol 2,3-nonanediol, 1,2-decanediol or the aforementioned antimicrobial components Mix for two or more minutes.

[0222] Of the above alkanediol / antimicrobial combinations, 1,2-heptanediol or 2 ,3-alkanediols, in particular 2,3-heptanediol and 2,3-octanediol; 2,3-nonanediol and 2,3-undecanediol, or the first linear alkane In combination with a mixture containing a diol and a second alkanediol, excellent synergistic anti-inflammatory properties were observed. This effect is demonstrated in the following examples by the Preservative Efficacy Test (PET). It is proven.

[0223] Therefore, specific preferred compositions according to the first or second aspects of the invention include The new alkanediol / antimicrobial combination of components (a) and (b) is: 1,2-heptanediol and 4-hydroxyacetophenone, or 1,2-heptanediol and o-cymen-5-ol (SymOcide C), or 1,2-heptanediol and propanediol caprylate (Crinipan P MC Green), or 1,2-heptanediol and climbazole (Crinipan AD), or 1,2-heptanediol and 2-methyl-5-cyclohexylpentanol (Sym Deo B125), or 1,2-Heptanediol and Ethylhexylglycerin (Sensiva SC5 0), or 1,2-heptanediol and sodium benzoate, or 1,2-heptanediol and farnesol, or 1,2-heptanediol and benzyl alcohol, or 1,2-heptanediol and phenoxyethanol, or 1,2-heptanediol and glyceryl caprylate (Symlite G8), or 1,2-heptanediol and potassium sorbate, or 1,2-heptanediol and isopropylparaben, or 1,2-heptanediol and sodium methylparaben, or 1,2-heptanediol and DMDM ​​hydantoin, or 1,2-heptanediol and methylchloroisothiazolinone, or 1,2-heptanediol and methylisothiazolinone, or 1,2-heptanediol and caprylhydroxamic acid, or 1,2-octanediol and 2,3-octanediol, or 1,2-nonanediol and 4-hydroxyacetophenone, or 2,3-heptanediol and 4-hydroxyacetophenone, or 2,3-heptanediol and potassium sorbate, or 2,3-heptanediol and phenoxyethanol, or 2,3-heptanediol and benzyl alcohol, or 2,3-heptanediol and lactic acid, or 2,3-heptanediol and benzyl salicylate, or 2,3-heptanediol and disodium EDTA, or 2,3-heptanediol and caprylhydroxamic acid, or 2,3-heptanediol and phytic acid, or 2,3-heptanediol and ethylhexylglycerin, or 2,3-heptanediol and glyceryl caprylate, or 2,3-octanediol and 4-hydroxyacetophenone, or 2,3-octanediol and potassium sorbate, or 2,3-octanediol and phenoxyethanol, or 2,3-octanediol and benzyl alcohol, or 2,3-octanediol and lactic acid, 2,3-octanediol and benzyl salicylate, or 2,3-octanediol and disodium EDTA, or 2,3-octanediol and caprylhydroxamic acid, or 2,3-octanediol and phytic acid, 2,3-octanediol and ethylhexylglycerin, 2,3-octanediol and glyceryl caprylate, 2,3-nonanediol and 4-hydroxyacetophenone, or 2,3-nonanediol and potassium sorbate, or 2,3-nonanediol and phenoxyethanol, or 2,3-nonanediol and benzyl alcohol, or 2,3-nonanediol and lactic acid, or 2,3-nonanediol and benzyl salicylate, or 2,3-nonanediol and disodium EDTA, or 2,3-nonanediol and caprylhydroxamic acid, or 2,3-nonanediol and phytic acid, or 2,3-nonanediol and ethylhexylglycerin, or 2,3-nonanediol and glyceryl caprylate.

[0224] Even more preferred alkanediols / diols according to the first or second aspect of the present invention In the antimicrobial combination, component (a) is a compound selected from two different antimicrobial compounds in combination with an antimicrobial component. A mixture of alkanediols: 1,2-pentanediol and 2,3-pentanediol, as well as 4-hydroxybenzoates acetophenone, or 1,2-pentanediol and 2,3-pentanediol, and potassium sorbate Umm, or 1,2-pentanediol and 2,3-pentanediol, as well as phenoxyethanol Knoll, or 1,2-pentanediol and 2,3-pentanediol, as well as benzyl alcohol rule, or 1,2-pentanediol and 2,3-pentanediol and lactic acid, or 1,2-pentanediol and 2,3-pentanediol, and benzoyl salicylate Jill, or 1,2-Pentanediol and 2,3-Pentanediol, and EDTA dihydrate sodium, or 1,2-pentanediol and 2,3-pentanediol, as well as caprylhydrol xamic acid, or 1,2-pentanediol and 2,3-pentanediol, and phytic acid, or 1,2-pentanediol and 2,3-pentanediol, and ethylhexyl glycerin, or 1,2-pentanediol and 2,3-pentanediol, and glycerin Seryl, or 1,2-Hexanediol and 2,3-Hexanediol, as well as 4-hydroxybenzoates acetophenone, or 1,2-Hexanediol and 2,3-Hexanediol, and potassium sorbate Umm, or 1,2-Hexanediol and 2,3-Hexanediol, as well as phenoxyethanol Knoll, or 1,2-Hexanediol and 2,3-Hexanediol, as well as benzyl alcohol rule, or 1,2-hexanediol and 2,3-hexanediol and lactic acid, or 1,2-Hexanediol and 2,3-Hexanediol, and Benzosalicylate Jill, or 1,2-Hexanediol and 2,3-Hexanediol, and EDTA dinamate sodium, or 1,2-Hexanediol and 2,3-Hexanediol, as well as caprylhydrol xamic acid, or 1,2-Hexanediol and 2,3-Hexanediol, and phytic acid, or 1,2-Hexanediol and 2,3-Hexanediol, and Ethylhexyl glycerin, or 1,2-Hexanediol and 2,3-Hexanediol, and Glycocaprylate Seryl, or 1,2-heptanediol and 2,3-heptanediol, as well as 4-hydroxybenzoates acetophenone, or 1,2-heptanediol and 2,3-heptanediol, and potassium sorbate Umm, or 1,2-heptanediol and 2,3-heptanediol, as well as phenoxyethanol Knoll, or 1,2-heptanediol and 2,3-heptanediol, as well as benzyl alcohol rule, or 1,2-heptanediol and 2,3-heptanediol and lactic acid, or 1,2-heptanediol and 2,3-heptanediol, and salicylic acid benzoate Jill, or 1,2-heptanediol and 2,3-heptanediol, and EDTA dinamate sodium, or 1,2-heptanediol and 2,3-heptanediol, as well as caprylhydrol xamic acid, or 1,2-heptanediol and 2,3-heptanediol, and phytic acid, or 1,2-heptanediol and 2,3-heptanediol, and ethylhexyl glycerin, or 1,2-heptanediol and 2,3-heptanediol, and glycerin caprylate Seryl, or 1,2-octanediol and 2,3-octanediol, as well as 4-hydroxybenzoates acetophenone, or 1,2-octanediol and 2,3-octanediol, and potassium sorbate Umm, or 1,2-octanediol and 2,3-octanediol, as well as phenoxyethanol Knoll, or 1,2-octanediol and 2,3-octanediol, as well as benzyl alcohol rule, or 1,2-octanediol and 2,3-octanediol and lactic acid, or 1,2-octanediol and 2,3-octanediol, and salicylic acid benzoate Jill, or 1,2-octanediol and 2,3-octanediol, and EDTA dinamate sodium, or 1,2-octanediol and 2,3-octanediol, as well as caprylhydroxamic acid xamic acid, or 1,2-octanediol and 2,3-octanediol, as well as phytic acid, or 1,2-octanediol and 2,3-octanediol, and ethylhexyl glycerin, or 1,2-octanediol and 2,3-octanediol, and glycerin caprylate Seryl, or 1,2-nonanediol and 2,3-nonanediol, and 4-hydroxyacetone tofenone, or 1,2-nonanediol and 2,3-nonanediol, and potassium sorbate ,or 1,2-nonanediol and 2,3-nonanediol, and phenoxyethanol or 1,2-nonanediol and 2,3-nonanediol, and benzyl alcohol ,or 1,2-nonanediol and 2,3-nonanediol and lactic acid, or 1,2-nonanediol and 2,3-nonanediol, and benzyl salicylate ,or 1,2-nonanediol and 2,3-nonanediol, and EDTA disodium hm, or 1,2-nonanediol and 2,3-nonanediol, and caprylhydroxamic acid nicotinic acid, or 1,2-nonanediol and 2,3-nonanediol and phytic acid, or 1,2-nonanediol and 2,3-nonanediol, and ethylhexylglycerin Serine, or 1,2-nonanediol and 2,3-nonanediol, and caprylic / glyceryl glycerin or 1,2-decanediol and 2,3-decanediol, as well as 4-hydroxyacetone tofenone, or 1,2-decanediol and 2,3-decanediol, and potassium sorbate ,or 1,2-decanediol and 2,3-decanediol, and phenoxyethanol or 1,2-decanediol and 2,3-decanediol, and benzyl alcohol ,or 1,2-decanediol and 2,3-decanediol and lactic acid, or 1,2-decanediol and 2,3-decanediol, and benzyl salicylate ,or 1,2-Decanediol and 2,3-Decanediol, and EDTA disodium hm, or 1,2-decanediol and 2,3-decanediol, and caprylhydroxane nicotinic acid, or 1,2-decanediol and 2,3-decanediol and phytic acid, or 1,2-decanediol and 2,3-decanediol, and ethylhexylglycerin Serine, or 1,2-decanediol and 2,3-decanediol, and caprylic glycerin or 1,2-undecanediol and 2,3-undecanediol, as well as 4-hydroxybenzoates acetophenone, or 1,2-undecanediol and 2,3-undecanediol, and sorbic acid potassium, or 1,2-undecanediol and 2,3-undecanediol, and phenoxy ethanol, or 1,2-undecanediol and 2,3-undecanediol, as well as benzyl alcohol Alcohol, or 1,2-undecanediol and 2,3-undecanediol, and lactic acid, teeth 1,2-undecanediol and 2,3-undecanediol, and salicylic acid benzyl, or 1,2-undecanediol and 2,3-undecanediol, and EDTA sodium, or 1,2-undecanediol and 2,3-undecanediol, as well as caprylic / capric triglycerides doxamic acid, or 1,2-undecanediol and 2,3-undecanediol, and phytic acid ,or 1,2-undecanediol and 2,3-undecanediol, as well as ethylhexyl glycerin, or 1,2-undecanediol and 2,3-undecanediol, and caprylic acid Contains glyceryl.

[0225] The combination provides protection against bacteria, yeasts and fungi / molds as described in the examples below. Synergistic antimicrobial efficacy is achieved.

[0226] The most preferred alkanediols in the compositions according to the first or second aspect of the present invention are The antimicrobial combination of ol / components (a) and (b) is: 1,2-heptanediol and 1,2-decylene glycol 1,2-heptanediol and anisic acid 1,2-heptanediol and tropolone 1,2-heptanediol and disodium EDTA 1,2-heptanediol and 2,3-heptanediol 1,2-heptanediol and hydroxyethoxyphenylbutanone 1,2-heptanediol and phytic acid 1,2-heptanediol and levulinic acid and its esters and / or ketones Rule 1,2-heptanediol and 1,3-propanediol 1,2-Heptanediol and Tetrasodium Glutamate Diacetate (Dissolving ne GL47 S) 1,2-heptanediol and thymol 1,2-heptanediol and Dragosantol 100 (bisabolol) 1,2-heptanediol and methylparaben 1,2-heptanediol and ethylparaben 1,2-heptanediol and benzyl salicylate 1,2-heptanediol and hydroxyethoxyphenylbutanol 1,2-heptanediol and 1,2-octanediol 1,2-heptanediol and sodium lactate.

[0227] 1,2-Heptane in combination with 1,2-decylene glycol, anisic acid, or tropolone Tandiol has a broad spectrum of activity against microorganisms, i.e., bacteria, yeasts and fungi / molds. Surprisingly, the synergistic antimicrobial effects are extremely difficult to achieve. Candida, which is known to be treated only by icans and Aspergillus, e.g., Aspergillus brasi This was also demonstrated in liensis.

[0228] On the other hand, EDTA, 2,3-heptanediol or hydroxyethoxyphenylbutanoic acid 1,2-heptanediol in combination with benzophenone exhibits synergistic antimicrobial activity against bacteria and yeast It has an effect.

[0229] Furthermore, the synergistic antimicrobial effect against bacteria was observed with phytic acid, levulinic acid, and 1,3-proline. Pandiol, tetrasodium glutamate diacetate (Dissolvine GL47S) , Thymol, Dragosantol 100 (Bisabolol), Methylparaben, Ethyl in combination with propylparaben, benzyl salicylate or hydroxyethoxyphenyl butanol This was also achieved with 1,2-heptanediol.

[0230] The particular combinations defined above may be combined with one or more of the further structures described below. It can be combined with other ingredients.

[0231] In a preferred and advantageous variant, the composition according to the first or second aspect of the invention comprises the following alkanol: Can / contains one of the antimicrobial combinations of components (a) and (b), and the antimicrobial component (b) is a 2,3-alkanediol: 1,2-pentanediol and 2,3-pentanediol, or 1,2-hexanediol and 2,3-hexanediol, or 1,2-heptanediol and 2,3-heptanediol, or 1,2-octanediol and 2,3-octanediol, or 1,2-nonanediol and 2,3-nonanediol, or 1,2-decanediol and 2,3-decanediol, or 1,2-undecanediol and 2,3-undecanediol, or 1,2-dodecanediol and 2,3-dodecanediol.

[0232] In particular such alkanediol / antimicrobial combinations, the antimicrobial component (b) is It is different from the alkanediol component (a) of the composition according to the second aspect of the invention.

[0233] Such alkanediol / antimicrobial combinations are useful as demonstrated in the examples below. As compared with each single alkanediol substance, it is particularly effective against a wide range of microorganisms, i.e. i.e., it has synergistic antimicrobial efficacy against bacteria, yeast and fungi / molds.

[0234] To further improve antimicrobial efficacy, the compositions defined herein advantageously comprise at least one further antimicrobial agent different from component (b) of the composition according to the invention The combination with an additional antimicrobial agent may improve the preparation, especially during storage. It provides reliable protection against microbial degradation and deterioration of materials. As mentioned above, the antimicrobial agents used can also inhibit the growth of other microorganisms, such as Corynebacterium m, Anaerococcus, Finegoldia, Moraxella, Porp hyromonas, Fusobacterium, Malassezia, Pepto niphilus, Streptococcus, Lactobacillus, Gar dnerella, Fannyhessea, Epidermophyton, Tric Provides reliable protection against Pseudomonas aeruginosa, Pseudomonas aeruginosa, and Cutibacterium Therefore, by combining different antimicrobial agents, it is possible to target different groups of microorganisms, and thus This allows for antimicrobial protection against a wider range of microorganisms. With the antimicrobial agent, preferably an antimicrobial agent for skin protection, the composition according to the invention can Microbial targets may also be indicated.

[0235] Further different antimicrobial agents in connection with the present invention are preferably 2-benzylheptanol, Alkyl (C12-22) trimethylammonium bromide and chloride, ascorbic acid carboxylic acid and its salts, benzalkonium bromide, benzalkonium chloride, benzalkonium saccharinate Benzethonium chloride, benzoic acid, camphor, cetylpyridinium chloride, dimethicone Chlorhexidine acetate, chlorhexidine dihydrochloride, chlorocresol, chloroxylenol ethanol, cyclohexylglycerin, dimethylphenylbutanol, dimethylphenylpropional Alcohol, Ethanol, Ethyl Lauroyl Arginate HCl, Ethyl Lauroyl Arginate Solaurate, Eucalyptol, Gluconic Acid and its Salts, Glycerin, Hexamid , hexamidine diisethionate, hexylglycerin, butylcarbamic acid, proiodide Pinil, jasmol, lauryl alcohol, levulinic acid and its esters esters and / or ketals, mannitol, menthol, methyl salicylate, octenyl Gin HCl, Polyarginine, Polyglyceryl-10 Laurate, Polyglyceryl Caprate Polyglyceryl-2, Polyglyceryl-3 Caprylate, Polylysine, Salvia Officinalis alis (sage) oil, silver chloride, silver citrate, sodium caproyl lactylate, caprylic / capric triglyceride Sodium Lauroyl / Lauroyl Lactylate, Sodium Lauroyl Lactylate, Sol Vinyl Acid, Sorbitol, Tetraselmis Extract, Triclocarban, Triclosan, Kue Triethyl Phosphate, Xylityl Sesquicaprylate, Zinc Citrate, Zinc Pyrithione, Lysinolate zinc phosphate, and mixtures of two or more of the foregoing antimicrobial agents.

[0236] In a more preferred version, the additional antimicrobial agent is 2-benzylheptanol, benzoyl benzoate, Fragrance, Dimethylphenylbutanol, Dimethylphenylpropanol, Ethyl Lauroyl Alginate HCl, Ethyl Lauroyl Arginate Laurate, Gluconic Acid and its Salt, glyceryl laurate, jasmol, lauryl alcohol, levulinic acid and its esters Esters and / or ketals, mannitol, octenidine HCl, polyglycerin, lauric acid Glyceryl-10, Polyglyceryl-2 Caprate, Polyglyceryl-3 Caprylate, Sa Ivia Officinalis (Sage) Oil, Sodium Caproyl Lactylate, Sodium Caproyl / Lauroyl Lactylate, Sodium Lauroyl Lactylate, Sorbic Acid, Sorbitol, Tetraselmis Extract, Triclosan, Triethyl Citrate , xylityl sesquicaprylate, zinc ricinoleate, and two or more of the aforementioned antimicrobial agents. The compound is selected from the group consisting of the above mixtures.

[0237] Within the context of the present invention, the composition according to the first or second aspect of the invention may be used in combination with other It may also be combined with conventional agents, adjuvants or additives, and in some cases This is advantageous in the market.

[0238] Optionally, as further described below, in a food, cosmetic or pharmaceutical composition, or or other conventional agents, adjuvants or additives customarily used in home care products. i.e. a ready-to-use preparation or formulation, such as a food, cosmetic or pharmaceutical preparation added as component (c) to obtain food, animal husbandry preparations or home care products It is possible.

[0239] The compositions according to the invention may advantageously contain other active agents and / or adjuvants and / or They may be combined with additives or auxiliaries, which may be used in, for example, food, cosmetic or pharmaceutical preparations. customarily used in pharmaceuticals, animal husbandry preparations, or home care products, e.g. Abrasive, anti-acne, anti-aging agent, anti-cellulitis, anti-dandruff, anti-inflammatory anti-irritant, anti-irritant, antioxidant, astringent, odor absorber, antiperspirant, disinfectant, antibacterial Antistatic agents, binders, buffers, carrier materials, chelating agents, cell stimulants, cleansing agents, removal agents Hair treatments, surfactants, deodorants, antiperspirants, fabric softeners, emulsifiers, enzymes, enzyme inhibitors, Essential oils, fibers, film formers, fixatives, foam formers, foam Stabilizers, anti-foaming substances, foam boosters, gelling agents, gel-forming agents, hair care agents, hair setting agents, shrink agents Hair straightener, moisture donor, moisturizing agent, water-retaining agent, bleaching agent, strengthening agent, dye remover, optical enhancer Whitening agents, impregnating agents, antifouling agents, pigments, friction reducers, lubricants, moisturizing creams, ointments, opacifying agents, Plasticizers, coatings, polishes, preservatives, brighteners, green and synthetic polymers, powders, Protein, re-oiling agent, abrasive, silicone, skin-soothing agent agents), skin cleansing agents, skin care agents, skin healing agents, whitening agents, skin protective agents , skin softener, hair growth promoter, cooling agent, skin cooling agent, warming agent, skin warming agent, stabilizer, surfactant Antibacterial agent, UV absorber, UV filter, 1st sun protection factor, 2nd sun protection factor, washing agent, fabric conditioning agent, suspending agent, skin tanning agent, skin or hair pigmentation regulator active ingredients, matrix metalloproteinase inhibitors, skin moisturizers, glycosaminoglycans Lycan stimulators, TRPV1 antagonists, desquamating agents, anti-cellulite or fat-enhancing agents , hair growth activators or inhibitors, thickeners, rheological additives, vitamins, oils, waxes Fat, pearlescent wax, fats, phospholipids, saturated fatty acids, monounsaturated or polyunsaturated fats Acids, α-hydroxy acids, polyhydroxy fatty acids, liquefying agents, dyes, color protectants, pigments, rust inhibitors Fragrances or perfume oils, fragrances, flavoring substances, odoriferous substances, polyols, electrolytes, organic solvents, as well as mixtures of two or more of the foregoing materials, as further described below.

[0240] The above cosmetic or pharmaceutical active agents and / or adjuvants against skin ageing and / or among the additives or auxiliaries, antioxidants, chelating agents, emulsifiers, surfactants, Green and synthetic polymers, skin cooling agents, rheological additives, oils, fragrances or Perfume oils and polyols are particularly preferred for the preparation of cosmetic and pharmaceutical compositions.

[0241] The cosmetically or pharmaceutical active agents and / or adjuvants and / or additives may be In some instances, one or more benefits may be obtained or may be produced via more than one mode of operation. Move.

[0242] The skin lesion or disease may be associated with dry skin, wound skin, skin lesions or even inflammation. Therefore, the composition according to the invention advantageously contains preferably an anti-inflammatory, antibacterial or antifungal agent. Antibacterial agents, substances that reduce redness or itching, pain relievers, moisturizers and / or cooling agents, osmolytes, keratolytics, nurturing agents, anti-inflammatory agents, antibacterial agents, or antifungal substances, substances that reduce redness or itching, analgesic substances, antidandruff substances or other active compounds, such as solvents, fragrances, antioxidants, preservatives, (metal) chelates a permeation enhancer, or two or more of the above-mentioned agents, as further described below. Contains a mixture of:

[0243] Anti-aging actives: The compositions according to the invention preferably contain one or more anti-aging actives. In the context of the present invention, anti-aging or regenerative active substances are used in combination with Biogenic agents include, for example, antioxidants, matrix- Metalloproteinase inhibitors (MMPIs), skin moisturizers, glycosaminoglycan stimulators, It is an anti-inflammatory agent, a TRPV1 antagonist and a plant extract.

[0244] Antioxidants: The compositions according to the present invention are preferably combined with one or more antioxidants. Suitable antioxidants include amino acids (preferably glycine, histidine, tyrosine, thiamin ... tryptophan) and its derivatives, imidazole (preferably urocanic acid) and its derivatives Derivatives, peptides, preferably D,L-carnosine, D-carnosine, L-carnosine and and its derivatives (preferably anserine), carnitine, creatine, matricaria peptides threonyl-threonyl-lysyl-serine and palmitoyl Carotenes (preferably alpha-carotene, beta-carotene), Carotene, lycopene) and derivatives thereof, lipoic acid and derivatives thereof (preferably dihydrogen Lipoic acid), gold thioglucose, propylthiouracil and other thiols (preferably thiols) Oredoxin, glutathione, cysteine, cystine, cystamine and glycosyl, N -Acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl , oleyl, gamma-linoleyl, cholesteryl, glyceryl and its oligoglycerides esters) and their salts, dilauryl thiodipropionate, distearyl thiodipropionate thiodipropionic acid and its derivatives (preferably esters, ethers, peptides) tides, lipids, nucleotides, nucleosides and salts), and very poorly tolerated (e.g. A sulfoximine compound (preferably buthionine sulfonate) in, for example, pmol to μmol / kg Sulfoximine, homocysteine ​​sulfoximine, buthionine sulfone, penta-, hexa -, heptathionine sulfoximine), and (metal) chelating agents (preferably alpha -hydroxy fatty acids, palmitic acid, phytic acid, lactoferrin, alpha-hydroxy Acids (preferably citric acid, lactic acid, malic acid), humic acid, bile acids, bile extract, tannic acid , bilirubin, biliverdin, EDTA, EGTA and their derivatives), unsaturated fatty acids and its derivatives (preferably gamma-linolenic acid, linoleic acid, oleic acid), folic acid and and its derivatives, ubiquinone and its derivatives, ubiquinol and its derivatives, vitamin Ascorbyl C and derivatives (preferably ascorbyl palmitate, magnesium ascorbyl phosphate, acetic acid) ascorbyl acid, ascorbyl glucoside), tocopherol and derivatives (preferably Vitamin E acetate), Vitamin A and derivatives (Vitamin A palmitate) and Benzoic acid resin coniferyl benzoate, rutinic acid and its Derivatives of flavonoids and their glycosylated precursors, in particular quercetin and its derivatives Preferably alpha-glucosylrutin, rosmarinic acid, carnosol, carnosol carnosolic acid, resveratrol, caffeic acid and its derivatives, sinapic acid and its derivatives, ferulic acid and its derivatives, curcuminoids, Chlorogenic acid and its derivatives, retinoids, preferably retinyl palmitate, retinoic acid or tretinoin, ursolic acid, levulinic acid and its esters and / or ketal, butylhydroxytoluene, butylhydroxyanisole, nordihydro Guaiac acid (nordihydroguaiac acid) Aretic acid, trihydroxybutyrophenone, uric acid and its derivatives, mannose and its derivatives, zinc and its derivatives (preferably ZnO, ZnSO4), selenium and its derivatives derivatives (preferably selenium methionine), superoxide dismutase, stilbe Stilbene and its derivatives (preferably stilbene oxide, trans-stilbene oxide) ), as well as derivatives (salts, etc.) of these cited active ingredients which are suitable according to the invention. esters, ethers, sugars, nucleotides, nucleosides, peptides and lipids), or Plants with an oxidizing effect, preferably green tea, rooibos, honeybush, grapes, rosemary Lee, sage, melissa, thyme, lavender, olive, oat, cacao, icing U, ginseng, licorice, honeysuckle, sophora, pueraria, pine, citrus Tachibana, Phyllanthus emblica or St. John's wort, Grape seeds wheat germ, extract or fraction of Phyllanthus emblica, co-fermented yeast Preferred are coenzyme Q10, plastoquinone and menaquinone. The most important antioxidants are vitamin A and derivatives, vitamin C and derivatives, tocopherols and and derivatives thereof, preferably tocopherol acetate, and ubiquinone. When vitamin E and / or its derivatives are used as antioxidant(s), A concentration ranging from about 0.001 to about 10% by weight, based on the total weight of the composition, can be selected. Vitamin A or a vitamin A derivative, or carotene or a derivative thereof, is advantageous. When the conductor is used as antioxidant(s), it is used in an amount of about 0. It is advantageous to choose a concentration ranging from 0.01 to about 10% by weight.

[0245] Matrix-metalloproteinase inhibitors (MMPIs): The compositions according to the present invention preferably or one or more matrix metalloproteinase inhibitors, especially collagen In combination with an inhibitor of matrix metalloproteinases that enzymatically cleave , they are ursolic acid, retinyl palmitate, propyl gallate, precocene, 6- Hydroxy-7-methoxy-2,2-dimethyl-1(2H)-benzopyran, 3,4-di Hydro-6-hydroxy-7-methoxy-2,2-dimethyl-1(2H)-benzopyran , benzamidine hydrochloride, cysteine ​​proteinase inhibitor N-ethylmalemide (Ne thylmalemide) and the serine protease inhibitor epsilon-amino-n -Caproic acid: phenylmethylsulfonyl fluoride onylfluoride), colhibin (Pentaphar) Company M; INCI: Hydrolyzed rice protein), oenotherol (Soliance; INCI: PG, Water, Evening Primrose Root Extract, Ellagic Acid and Ellagitannins (e.g., from pomegranate), phosphoramidones, hinokitiol, EDTA, MG DA (dicarboxymethylalanine trisodium), Galardin, EquiStat (C Collaborative Group; Apple Fruit Extract, Soybean Seed Extract, Urushi Extract Solic acid, soy isoflavones and soy protein), sage extract, MDI (At rium; INCI: mucopolysaccharide), Fermiskin (Silab / Mawi; INC I: water and shiitake mushroom extract), actimp 1.9.3 (Expanscience / Rahn; INCI: Hydrolyzed Lupin Protein, Lipobena glycoside (Mi Belle Inc.; INCI: Ethanol, Polysorbate 80, Lecithin and Soybean Isopropyl Myristate flavones), extracts from green and black tea and further plant extracts, tamarind from soybean Protein or glycoprotein, hydrolyzed protein from rice, pea or lupin a plant extract that inhibits MMP, preferably an extract from a mushroom called shiitake; Extracts from the leaves of the family Rosaceae, subfamily Rosaceae, in particular e.g. SymMatrix (Symrise) , INCI: Maltodextrin, Blackberry (like Rubus fruticosus leaf extract) The preferred active ingredients are selected from the group consisting of retinyl palmitate, Ursolic acid, Rosaceae, Rosaceae leaf extract, genistein and daidzein is selected from the group consisting of:

[0246] Skin moisturizers: Preferred compositions according to the present invention comprise one or more skin moisturizers. Preferred skin moisturizers are alkanediols or alkanethiols containing 3 to 12 carbon atoms. Triol, preferably C3-C 10 -Alkanediols and C3-C 10 -Alcanto More preferably, the skin moisturizer is selected from the group consisting of glycerol, 1,2-dimethylaminopropyl methylcellulose ... ,2-Propylene glycol, 1,2-butylene glycol, 1,3-butylene glycol 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol , 1,2-octanediol and 1,2-decanediol.

[0247] Glycosaminoglycan stimulators: Preferred compositions according to the present invention contain glycosaminoglycan stimulators. The compound contains one or more substances that stimulate the synthesis of hyaluronic acid, including hyaluronic acid and derivatives thereof. or salt, Subliskin (Sederma, INCI: Alfalfa) Sinorhizobium Meliloti Ferment Filtrate), Cetyl Hydroxyethylcellulose, Lecithin), Hyalufiq Hyalufix (BASF, INCI: Water, BG, Anthoclase Leaf Extract (A lpinia galanga leaf extract), xanthan gum, tri( Caprylic / Capric Glyceryl), Stimulhyal (S oliance, INCI: Calcium ketogluconate, Syn-Glycan (Syn-Glyc an) (DSM, INCI: Tetradecylaminobutyroylvalylamine trifluoroacetate) Tetradecyl Aminobutyroylvalylamin obutyric urea trifluoroacetate), glycerin, chloride Mg), Kalpariane (Biotech Marine), D C Upregulexx (Distinctive C Osmetic Ingredients, INCI: Water, BG, Phospholipids, Hydrolyzed Ceteth-10 Lysine), glucosamine, N-acetylglucosamine, retinoids, preferably retinoids and Vitamin A, Arctium lappa fruit extract, Eriobotrya japonica extract, Genkwanin, N-methyl-L-serine, (-)-alpha- Bisabolol or synthetic alpha-bisabolol, e.g. Dragosa from Symrise Dragosantol and Dragosantol 100, Oat Gurkha Ingredients: Echinacea purpurea extract and soy protein hydrolysate Preferred active substances are selected from the group consisting of hyaluronic acid and derivatives or salts, Bisabolol and derivatives, (-)-alpha-bisabolol or synthetic alpha-bisabolol ols, e.g. Dragosantol from Symrise and Dragosantol 100, Oat Glucan, Echinacea purpurea Extract, Sinorhizobium Meliloti Ferment Filtrate, Ketogluconic Acid Calcium Sodium, Alpinia galanga leaf extract and tetradecyl trifluoroacetate aminobutyroylvalylaminobutyric acid urea.

[0248] TRPV1 Antagonists: Preferred compositions according to the present invention contain one or more TRP It contains V1 antagonists. As a TRPV1 antagonist, it is effective against the skin based on its action. Suitable compounds for suppressing neuronal hypersensitivity include, for example, trans-4-tert-butylcyclohexyl or μ-receptors, e.g., acetyltetrapeptide-15 Indirect regulators of TRPV1 through activation of TRPV1 are preferred.

[0249] Plant extracts: Preferred compositions according to the present invention comprise one or more plant extracts. Plant extracts, particularly highly active plant extract fractions, and also highly pure compounds isolated from plant extracts. Nourishing agents may also be used in the compositions according to the invention. miphora species, Rubia species, willow, red herb, ginger, marigold, Al Extracts from Nica, Glycyrrhiza species, Echinacea species, Rubus species, Fractions and active substances, as well as pure substances, such as, inter alia, bisabolol, apigenin, apigenin, Pigenin-7-glucoside, gingerols, e.g. [6]-gingerol, paradol Examples include [6]-paradol, boswellic acid, plant sterols, glycyrrhizin, Labridin or licochalcone A are particularly preferred.

[0250] Anti-inflammatory agents: The compositions according to the present invention preferably contain anti-inflammatory agents and / or anti-redness and and / or in combination with ingredients that relieve itching, especially corticosteroid-type steroids. The steroid substances are hydrocortisone, dexamethasone, dexamethasone phosphate, methyl prednisolone or cortisone, which are advantageously anti-inflammatory agents. Used as an active ingredient, or an active ingredient that relieves redness and itching, these listings are This can be expanded by adding other steroidal anti-inflammatory drugs. Nonsteroidal anti-inflammatory drugs are also used. More specifically: (i) steroidal anti-inflammatory substances of the corticosteroid type, in particular hydrocortisone, Hydrocortisone derivatives, such as hydrocortisone 17-butyrate, dexamethasone, dexamethasone phosphate, methylprednisolone or cortisone, (ii) nonsteroidal anti-inflammatory substances, in particular oxicams, such as piroxicam or tenoki cicam, salicylates, such as aspirin, disalcid, sorbicin or fendocer Acetic acid derivatives such as diclofenac, fenclofenac, indomethacin, thiamin danaquinac, tolmetin or clindanac, fenamates such as mefenamic, meclometin Fenamic, Flufenamic or Niflumic, propionic acid derivatives, e.g., Ibuprofen profen, naproxen or benoxaprofen, pyrazoles such as phenylbutadiene benzoxazole, oxyphenylbutazone, febrazone or azapropazone, (iii) natural or naturally occurring anti-inflammatory or anti-redness and / or itching substances Soothing substances, especially chamomile, aloe vera, Commiphora species, Rubia species, Willow, red herb, oat, calendula, arnica, St. John's wort, honey -suckle, rosemary, Passiflora incarnata, witch hazel, Extracts or fractions from ginger or echinacea, or their single active compounds, (iv) histamine receptor antagonists, serine protease inhibitors (e.g., soybean extract (e.g., 4-t-butylcyclohexanol), TRPV1 antagonists (e.g., 4-t-butylcyclohexanol), N K1 antagonists (e.g., aprepitant, hydroxyphenylpropamidobenzoic acid) , cannabinoid receptor agonists (e.g., palmitoylethanolamine) and TR PV3 antagonist.

[0251] Examples that may be cited herein are oxicams, such as piroxicam or tenoxicam; Salicylates, such as aspirin, disalcid, sorbicin or fendosal; acetic acid Derivatives such as diclofenac, fenclofenac, indomethacin, sulindac, tolmetin or clindanac; fenamates, e.g. mefenamic, meclofenamic propionic acid derivatives, e.g. ibuprofen benzophenone, naproxen, benoxaprofen or pyrazoles such as phenylbutazone, These are phenylbutazone, febranone, or azapropazone. Body is a preferred anti-itch ingredient in compositions according to the present invention.

[0252] Substances or mixtures of substances that relieve redness and / or itching, in particular chamomile, alfalfa, Loe vera, Commiphora species, Rubia species, willow, red herb, oat, and oats Cinnamon, Arnica, St. John's Wort, Honeysuckle, Rosemary, Pas Extracts from siflora incarnata, witch hazel, ginger, or echinacea Preferably chamomile, aloe vera, oat, calendula, arnica moss, honeysuckle, rosemary, witch hazel, ginger or echinacea, and / or or pure substances, preferably alpha-bisabolol, apigenin, apigenin-7-glucan Lucoside, gingerol, shogaol, shogadiol, dehydrogingerdione , paradol, natural, or naturally occurring avenanthramide, preferably tranilast , Avenanthramide A, Avenanthramide B, Avenanthramide C, Non-natural or Naturally Non-existent avenanthramides, preferably dihydroavenanthramide D, dihydroavena Avenanthramide E, Avenanthramide D, Avenanthramide E, Avenanthramide F, Bosu from ferric acid, plant sterols, glycyrrhizin, glabridin and licochalcone A extracts or fractions; preferably alpha-bisabolol, natural Avenanthramides, non-natural avenanthramides, preferably dihydroavenanthramide D( WO2004047833A1), boswellic acid, plant sterols, Glycyrrhizin, and Licochalcone A, and / or Allantoin, Panthenol, Lanolin, (pseudo)ceramides [preferably ceramide 2, hydroxypropyl bispalmitate] Myristamide MEA, Cetyloxypropyl Glyceryl Methoxypropyl Myristamide, N-(1 -hexadecanoyl)-4-hydroxy-L-proline (1-hexadecyl) ester, Hydroxyethyl Palmityloxyhydroxypropyl Palmitamide], Glycosphin lipids, plant sterols, chitosan, mannose, lactose and β-glucan, in particular 1,3->1,4-β-glucans from oats, Also useful are naturally occurring anti-inflammatory compounds.

[0253] Bisabolol, when used in connection with the present invention, may be of natural or synthetic origin. , preferably "alpha-bisabolol". Preferably, bisabolol is used is synthetically prepared or naturally occurring (-)-alpha-bisabolol and / or It is a synthetic mixed-isomer alpha-bisabolol. Natural (-)-alpha-bisabolol When used, essential oils or plant extracts or fractions thereof may be used. As elements, for example chamomile or vanillosmopsis (especially vanill osmopsis erythropappa or Vanillosmopsis a It may also be used as a component of (a fraction of) the oil or extract of (Salvia serrata). For example, Symrise sells pharmacokinetic drugs under the name "Dragosantol." It is available under the name

[0254] In cases where ginger extract is used in connection with the present invention, it is preferably fresh or dried ginger. Ginger root extract is used, which is dissolved in methanol, ethanol, isopropanol, and ethanol. Cetone, ethyl acetate, carbon dioxide (CO2), hexane, methylene chloride, chloroform, or other solvents or solvent mixtures of similar polarity. Active skin irritation reducing amounts of ingredients such as gingerol, shogaol, shogaol, Characterized by the presence of ugadiol, dehydrogingerdione, and / or paradol can be done.

[0255] Physiological cooling agents: The compositions according to the invention particularly advantageously contain one or more physiological cooling agents. It may be combined with cooling agent(s). The use of cooling agents may relieve itching. Individual coolants suitable for use within the framework of the present invention are listed below. Many other refrigerants may be added to this list; the refrigerants listed may be combined with each other. These may be used in combination with other compounds, which are preferably selected here from the following list: Menthol and menthol derivatives (e.g., L-menthol, D-menthol, racemic menthol, Toluene, isomenthol, neoisomenthol, neomenthol) methyl ether (e.g. (l-menthoxy)-1,2-propanediol, (l-menthoxy)-2-methyl- 1,2-Propanediol, l-Menthyl-methyl ether, Menthone glyceryl acetone tar, menthone glyceryl ketal or a mixture of both, menthyl esters (e.g., menthyl esters Menthyl formiate, menthyl acetate, menthyl isobutyrate, menthyl hydroxy Isobutyrate, Menthyl Lactate, L-Menthyl-L-Lactate, L-Menthyl- D-Lactic acid, Menthyl-(2-methoxy)acetate, Menthyl-(2-methoxyethoxy) ) acetate, menthyl pyroglutamate), menthyl carbonate (e.g., menthyl propionate) Propylene glycol carbonate, menthyl ethylene glycol carbonate, menthyl glycerol carbonate or mixtures thereof), menthol and dicarboxylic acids or Half-esters of derivatives of (e.g., mono-menthyl succinate, mono-menthyl glutarate) Mono-menthyl malonate, O-menthyl succinate-N,N-(dimethyl ) amide, O-menthyl succinic acid ester amide), menthanecarboxylic acid amide (this In the case of hydroxybenzoates, preferably menthanecarboxylic acid-N-ethylamide [WS3] or N α -( Menthanecarbonyl)glycine ethyl ester [WS5], Menthanecarboxylic acid-N-( N-(4-cyanomethylphenyl)-menthanecarboxylic acid (alkoxy) amide, menthanecarboxylic acid-N-(alkoxyalkyl) amide, menthone and and menthone derivatives (e.g., L-menthone glycerol ketal), 2,3-dimethyl-2 -(2-propyl)-butyric acid derivatives (e.g., 2,3-dimethyl-2-(2-propyl)-butyric acid derivatives) Acid-N-methylamide [WS23]), isopulegol or its ester (I-(-) -isopulegol, I-(-)-isopulegol acetate), menthane derivatives (e.g. p-menthane-3,8-diol), cubebol or cubebol Synthetic or natural mixtures containing pyrrolidone derivatives of cycloalkyldione derivatives (e.g. For example, 3-methyl-2(1-pyrrolidinyl)-2-cyclopenten-1-one) or tetramethyl Hydropyrimidin-2-ones (e.g., those described in WO 2004 / 026840) iciline or related compounds), further carboxamides (e.g., N-( 2-(pyridin-2-yl)ethyl)-3-p-menthanecarboxamide or related compounds (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(1- isopropyl)cyclohexane-carboxamide [WS12], oxamate and [( 1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl]2-(ethyl a X Cool)-2-oxo-acetate. Preferred cooling due to specific synergistic effects. The agent is l-menthol, d-menthol, racemic menthol, menthone glycerol acetate Tar (trade name: Frescolat® MGA), menthyl lactate (preferred or l-menthyl lactate, especially l-menthyl l-lactate (trade name: Fresc olat®ML), substituted menthyl-3-carboxamides (e.g., menthyl- 3-carboxylic acid N-ethylamide), 2-isopropyl-N-2,3-trimethylbutane Amides, substituted cyclohexanecarboxamides, 3-menthoxypropane-1,2-diol 2-Hydroxyethyl Menthyl Carbonate, 2-Hydroxypropyl Menthyl Carbonate Particularly preferred cooling agents are l-menthol, racemic isopulegol, and menthol. Menthol, Menthone Glycerol Acetal (trade name: Frescolat (registered trademark) ) MGA), menthyl lactate (preferably l-menthyl lactate, especially l-menthyl l-lactate (trade name: Frescolat® ML)), 3-menthoxy Propane-1,2-diol, 2-hydroxyethyl menthyl carbonate and 2-hydroxyethyl A very particularly preferred coolant is 1-methylhydroxypropyl menthyl carbonate. Menthol, Menthol Glycerol Acetal (trade name: Frescolat®) MGA) and menthyl lactate (preferably l-menthyl lactate, especially l-menthyl lactate) The compound is ethyl l-lactate (trade name: Frescolat® ML).

[0256] Moisturizing and / or water-retaining substances: Itching occurs with a certain intensity when the skin is dry. The use of skin moisturizing and / or water-retaining substances can significantly alleviate the itching. The composition according to the invention may therefore advantageously comprise one or more of the following moisturizing and / or hydrating substances: may contain several of: sodium lactate, urea, urea derivatives, alcohol, glycerol, Diols, such as propylene glycol, hexylene glycol, collagen, elastin or hyaluronic acid, diacyl adipate, petrolatum, urocanic acid, lecithin, bread Tenol, phytantriol, lycopene, (pseudo)ceramide, glycosphingolipid, cholesterol Sterol, plant sterol, chitosan, chondroitin sulfate, lanolin, lanolin esther esters, amino acids, alpha-hydroxy acids (e.g., citric acid, lactic acid, malic acid) and their derivatives, mono-, di- and oligosaccharides, e.g., glucose, galactose, frucrose, sugars, mannose, fructose and lactose, polysaccharides such as R-glucans, especially 1,3-1,4-β-glucan from oat, alpha-hydroxy fatty acids, triticale Lupexic acids, such as betulinic acid or ursolic acid, as well as algae extracts.

[0257] Analgesic substances: The compositions according to the invention may advantageously also contain one or more analgesic substances, Any analgesic substance suitable or customary for cosmetic or pharmaceutical use, such as alpha-bisaburo Azulene, Guaiazulene, 18-beta-glycyrrhetinic acid, Allantoin, Aroma Evera juice or gel, Hamamelis virginiana (witch hazel), Echinacea species, Centella asiatica, Chamomile, Arnic a monatana, Glycyrrhiza species, algae, seaweed and Calendul a officinalis extract, as well as vegetable oils, such as sweet almond oil , baobab oil, olive oil, as well as panthenol, laureth-9, trideceth-9, etc. Additionally, 4-t-butylcyclohexanol can be used.

[0258] Antibacterial or antifungal substances: In addition to the antimicrobial agents listed herein, antibacterial or antifungal substances The substances can also be used particularly advantageously in compositions according to the invention, in cosmetic or pharmaceutical applications, in particular Any antibacterial or antifungal substance suitable or customary for dermatological applications can be used. In addition to the large group of biomaterials, other products of interest here are those related to cosmetics. especially triclosan, climbazole, octoxyglycerin, Octop irox® (1-hydroxy-4-methyl-6-(2,4,4-trimethylpentylphenyl ether) (1H)-2(1H)-pyridone 2-aminoethanol salt), chitosan, farnesol glyceryl monolaurate or a combination of the foregoing.

[0259] Desquamating agents: The compositions according to the invention preferably contain one or more desquamating agents. The expression "debris" means: - any compound capable of acting directly on desquamation by promoting desquamation β-hydroxy acids, in particular salicylic acid and its derivatives (5-n-octanoyl including salicylic acid); alpha-hydroxy acids, such as glycolic acid, citric acid, lactic acid, and tartaric acid , malic acid or mandelic acid; urea; gentisic acid; oligofucose; cinnamic acid; So extract of Phora japonica; part of resveratrol and jasmonic acid derivative; - or corneodesmosomes, glycosidases, stratum corneum chymotrypsin enzymes (SC CE) or other proteases (trypsin, chymotrypsin-like) for desquamation or degradation It is also understood to mean any compound capable of acting on the enzyme involved. Chelating agents: EDTA; N-acyl-N,N',N'-ethylenediamine triacetic acid; aminosulfonic acid compounds, especially (N-2-hydroxyethylpiperazine-N-2 -ethane)sulfonic acid (HEPES); 2-oxothiazolidine-4-carboxylic acid (Pro Derivatives of alpha-amino acids of the glycine type (EP-0852 949 and marketed by BASF under the trade name TRILON M. Sodium methylglycine diacetate; honey; sugar derivatives, e.g. O- Octanoyl-6-D-maltose and N-acetylglucosamine; chestnut extract, e.g. For example, it is marketed by SILAB under the name Recoverine®. Prickly pear extract, e.g. Exfolactive (registered trademark) by SILAB or those marketed under the name "Degussa" (registered trademark) or Phytosphingosine SLC (registered trademark) (graphite with salicylic acid) Reference may be made to phytosphingosine (associated with phytosphingosine).

[0260] Desquamating agents suitable for the present invention include, in particular, sulfonic acids, calcium chelating agents, α-hydroxybenzoates, citric acids, such as glycolic acid, citric acid, lactic acid, tartaric acid, malic acid or mandelic acid; Ascorbic acid and its derivatives, such as ascorbyl glucoside and ascorbyl phosphate Magnesium; Nicotinamide; Urea; (N-2-hydroxyethylpiperazine-N-2 -ethane)sulfonic acid (HEPES), β-hydroxy acids such as salicylic acid and Derivatives, retinoids, such as retinol and its esters, retinol, retinoic acid and its derivatives, in particular chestnut or prickly pear marketed by SILAB a reduced compound, such as cysteine ​​or a cysteine ​​precursor; Desquamating agents that may be used include nicotinic acid, also known as vitamin B3 or vitamin PP. and its esters, as well as nicotinamide and ascorbic acid and its precursors. be.

[0261] Anti-dandruff substances: Furthermore, the composition according to the invention may contain triclosan, climbazole, octo Diglycerin, Octopirox® (1-hydroxy-4-methyl-6- (2,4,4-trimethylpentyl)-2(1H)-pyridone 2-aminoethanol salt , Chitosan, Farnesol, Glycerin Monolaurate, Propanediol Monocaprylate It may also be advantageous to combine it with one or more anti-dandruff substances, including acetaldehyde or a combination of said substances. These may be used, inter alia, against dandruff.

[0262] Further suitable anti-dandruff agents include piroctone olamine (1-hydroxy-4-methyl-6- (2,4,4-trimethylpentyl)-2-(1H)-pyridinone monoethanolamine Salt), Baypival® (Climbazole), Ketoconazol (Registered Trademark) Registered trademark) (4-acetyl-1-{4-[2-(2,4-dichlorophenyl)r-2-(1 H-imidazol-1-ylmethyl)-1,3-dioxiran-c-4-ylmethoxy {phenyl}-piperazine, ketoconazole, elubiol, selenium disulfide, colloid Sulfur, Sulfur Polyethylene Glycol Sorbitan Monooleate, Sulfur Ricinol Polyethene xylates, sulfur tar distillates, salicylic acid (or in combination with hexachlorophene) , undecylenic acid, monoethanolamide sulfosuccinate Na salt, Lamepon ( Registered trademark) UD (protein / undecylenic acid condensate), zinc pyrithione, aluminum Dipyrithione and Magnesium Pyrithione / Dipyrithione Magnesium Sulfate be.

[0263] (Metal) chelating agents: Combinations with one or more (metal) chelating agents are also possible according to the present invention. Any metal catalyst suitable or customary for cosmetic or pharmaceutical applications may be advantageously used in compositions containing Preferred (metal) chelating agents are alpha-hydroxy fatty acids, phytosterols, carboxylic acids, lactoferrin, α-hydroxy acids, such as, inter alia, gluconic acid, glyceric acid, Glycolic acid, isocitric acid, citric acid, lactic acid, malic acid, mandelic acid, tartaric acid, and Humic acid, bile acids, bile extract, bilirubin, biliverdin or EDTA, EGTA, MGDA (trisodium dicarboxymethylalanine), and their derivatives. The use of one or more chelating agent(s) improves the stability of the compositions according to the present invention. do.

[0264] Emulsifiers: Furthermore, the compositions according to the invention may advantageously contain, for example: - 2 to 30 mol ethylene oxide and / or 0 to 5 mol propylene oxide Linear C 8~22 Fatty alcohol, C 12~22 to fatty acids, and 8 to 15 addition products to alkylphenols containing carbon atoms in the alkyl group; - C for addition products of 1 to 30 mol of ethylene oxide to glycerol 12 / 18 fat fatty acid monoesters and diesters; - glycerol mono- and diglycerides of saturated and unsaturated fatty acids containing 6 to 22 carbon atoms and diesters, and sorbitan mono- and diesters, and their ethyl nitroxide addition products; - 15 to 60 mol ethylene oxide to castor oil and / or hydrogenated castor oil addition products; - polyol esters, and in particular polyglycerol esters, e.g. polyglycerol Polyglycerol polyricinoleate, polyglycerol poly-12-hydroxystearate or poly Diglycerol dimer isostearate. A mixture of compounds from several of these classes. Blends are also suitable; - Addition of 2 to 15 mol of ethylene oxide to castor oil and / or hydrogenated castor oil additive products; - Linear, branched, unsaturated or saturated C 6 / 22 Fatty acids, ricinoleic acid and 12-hydroxy Stearic acid and glycerol, polyglycerol, pentaerythritol, diphenyl ether Pentaerythritol, sugar alcohols (e.g., sorbitol), alkyl glucosides (e.g., methyl glucoside, butyl glucoside, lauryl glucoside) and polyglucosides ( partial esters based on, for example, cellulose; - mono-, di- and trialkyl phosphates and mono-, di- and / or tri- -PEG-alkyl phosphates and their salts; - Wool wax alcohol; - polysiloxane / polyalkylpolyether copolymers and corresponding derivatives; - mixed esters of pentaerythritol, fatty acids, citric acid and fatty alcohols, and / or C. 6~22 Fatty acids, methyl glucose and polyols, preferably glucose mixed esters of glycerol or polyglycerol, a polyalkylene glycol, - May also contain one or more emulsifiers including glycerol carbonate.

[0265] Ethylene oxide and / or propylene oxide fatty alcohols, fatty acids, alkylphenols, glycerol mono- and diesters of fatty acids and sorbitan mono- and diesters of fatty acids. The addition products to no- and diesters or to castor oil are known commercially available products. These are copolymers whose average degree of alkoxylation is ethylene oxide and / or propylene oxide. It is a homologous mixture corresponding to the ratio between the amount of ethylene oxide and the substrate on which the addition reaction is carried out. C of the addition products of ethylene oxide to glycerol 12 / 18 fatty acid monoesters and Diesters are known as lipid layer enhancers for cosmetic formulations. Preferred emulsifiers are: It is described in more detail as follows:

[0266] Partial glycerides: A typical example of a suitable partial glyceride is hydroxystearic acid monoglyceride. Glycerides, hydroxystearic acid diglyceride, isostearic acid monoglyceride, Isostearic acid diglyceride, oleic acid monoglyceride, oleic acid diglyceride, Ricinoleic acid monoglyceride, ricinoleic acid diglyceride, linoleic acid monoglyceride, Linoleic acid diglyceride, linolenic acid monoglyceride, linolenic acid diglyceride, eruca Acid monoglyceride, erucic acid diglyceride, tartaric acid monoglyceride, tartaric acid diglyceride , Citric acid monoglyceride, Citric acid diglyceride, Malic acid monoglyceride, Malic acid diglycerides, and the technology may still contain small amounts of triglycerides from the production process The mixture is preferably 1 to 30, more preferably 5 to 10 mol ethylenediamine. Also suitable are addition products of oxides to partial glycerides.

[0267] Sorbitan esters: A suitable sorbitan ester is sorbitan monoisostearate. , sorbitan sesquiisostearate, sorbitan diisostearate, triisostearate Sorbitan phosphate, sorbitan monooleate, sorbitan sesquioleate, dioleate Sorbitan phosphate, sorbitan trioleate, sorbitan monoerucate, sesquierucate Sorbitan, sorbitan dierucate, sorbitan trierucate, sorbitan monoricinoleate Sorbitan, sorbitan sesquiricinoleate, sorbitan diricinoleate, sorbitan triricinoleate Rubitan, Sorbitan Monohydroxystearate, Sorbitan Sesquihydroxystearate Sorbitan, Sorbitan dihydroxystearate, Sorbitan trihydroxystearate , sorbitan monotartrate, sorbitan sesquitartrate, sorbitan ditartrate, sorbitan tritartrate Rubitan, sorbitan monocitrate, sorbitan sesquicitrate, sorbitan dicitrate , sorbitan tricitrate, sorbitan monomaleate, sorbitan sesquimaleate, Sorbitan dimaleate, sorbitan trimaleate and their technical mixtures The so-called ethylene oxides of 1 to 30 and preferably 5 to 10 mol Addition products to rubitan esters are also suitable.

[0268] Polyglycerol esters: Typical examples of suitable polyglycerol esters are polyglycerol esters. Lyceryl-2 dipolyhydroxystearate (Dehymuls® PGPH) , polyglycerin-3-diisostearate (Lameform® TGI), Polyglyceryl-4 Isostearate (Isolan® GI 34), Olay Polyglyceryl-3 Phosphate, Diisostearyl Polyglyceryl-3 Diisostearate (I solan® PDI), Polyglyceryl-3 Methylglucose Distearate (Tego Care® 450), Polyglyceryl-3 Beeswax (Ce ra Bellina®), Polyglyceryl-4 Caprate (Polyglycerol Lucaprate T2010 / 90, Polyglyceryl-3 Cetyl Ether (Chimexa ne(R)NL), Polyglyceryl-3 Distearate (Cremophor(R) GS 32) and Polyglyceryl Polyricinoleate (Admul® )WOL 1403), polyglyceryl dimer isostearate, and mixtures thereof Other suitable polyol esters include trimethylolpropane or pentyl esters. Lauric acid reacted with thiaerythritol and optionally with 1 to 30 mol ethylene oxide , coconut fatty acid, tallow fatty acid, palmitic acid, stearic acid, oleic acid, behenic acid, etc. Mono-, di- and triesters.

[0269] Anionic emulsifiers: Typical anionic emulsifiers are aliphatic C12 to C22 fatty acids, e.g. For example, palmitic acid, stearic acid or behenic acid, and C12 to C22 dicarboxylic acids , for example azelaic acid or sebacic acid.

[0270] Amphoteric emulsifiers: Other suitable emulsifiers are amphoteric or zwitterionic surfactants. The ionic surfactant contains at least one quaternary ammonium group and at least one carboxyl group. It is a surface-active compound containing one carboxylate and one sulfonate group in the molecule. Particularly suitable zwitterionic surfactants are the so-called betaines, e.g., those with 8 to 18 carbon atoms. N-Alkyl-N,N-dimethylammonium chlorides containing a hydrogen atom in the alkyl or acyl group ammonium glycinates, e.g., cocoalkyldimethylammonium glycinate, N-acyl Aminopropyl-N,N-dimethylammonium glycinate, e.g., cocoacylamino Propyldimethylammonium glycinate, and 2-alkyl-3-carboxymethyl 3-hydroxyethyl imidazoline, and cocoacylaminoethyl hydroxyethyl It is carboxymethyl glycinate, and is publicly known under the CTFA name of cocamidopropyl betaine. Known fatty acid amide derivatives are particularly preferred. Amphoteric surfactants are also suitable emulsifiers. The surfactant is C 8 / 18 In addition to the alkyl or acyl group, at least one free alkyl group It contains an amino group and at least one -COOH- or -SO3H- group in the molecule, Examples of suitable amphoteric surfactants are: N-Alkylglycines containing 8 to 18 carbon atoms in the alkyl group, N-alkylpropionic acid, N-alkylaminobutyric acid, N-alkyliminodipropionic acid, N- Hydroxyethyl-N-alkylamidopropylglycine, N-alkyltaurine, N- Alkyl sarcosines, 2-alkylaminopropionic acids, and alkylaminoacetic acids. Particularly preferred amphoteric surfactants are N-cocoalkylaminopropionates, cocoacyl Aminoethylaminopropionate and C 12 / 18 It is an acyl sarcosine.

[0271] Surfactants: The compositions according to the invention preferably contain one or more anionic and and / or amphoteric or zwitterionic surfactants. Typical examples include: Almondamidopropylamine oxide, almondamidopropyl betaine, aminopropyl Hydroxypropyl lauryl glutamine, ammonium C12-15 alkyl sulfate, ammonium Ammonium C12-16 Alkyl Sulfate, Ammonium Caprylyl Sulfate m Capryleth Sulfate), Coco Monoglyceride Ammonium Sulfate (Amm ammonium cocoglyceride sulfate), ammonium cocosulfate Ammonium Coco-Sulfate, Ammonium Cocoyl Isethionate Ammonium Cocoyl Sarcosinate, C12-15 Pareth Ammonium Sulfate, C9- Ammonium C9-10 Perfluoroalkylsulfonate fluoroalkylsulfonate), dinonylammonium sulfosuccinate, Ammonium dodecylbenzenesulfonate, ammonium isostearate, laureth- Ammonium laureth-6 carboxylate, ammonium laureth-8 carboxylate, ammonium laureth sulfate Sodium, Laureth-5 Ammonium Sulfate, Laureth-7 Ammonium Sulfate, Laureth-9 Ammonium sulfate, ammonium laureth-12 sulfate, ammonium lauroyl sarcosinate Ammonium lauryl sulfate, ammonium lauryl sulfosuccinate, ammonium myreth sulfate ammonium, myristyl ammonium sulfate, nonoxynol-4 ammonium sulfate, nonoxynol-4 ammonium sulfate Xynol-30 ammonium sulfate, ammonium oleate, palm kernel ammonium sulfate Ammonium stearate, ammonium thalate, AMPD-isostearoyl Hydrolyzed Collagen (AMPD-lsostearoyl Hydrolyzed Collagen) lagen), AMPD-rosin hydrolyzed collagen, AMP-isostearoyl hydrolyzed collagen Decomposed collagen, AMP-isostearoyl hydrolyzed keratin, AMP-isostearoyl Hydrolyzed soy protein, AMP-isostearoyl hydrolyzed wheat protein, Ang Diazamidopropyl betaine, arachidic acid, hexyldecyl arginine phosphate, avocado Amidopropyl Betaine, Avocado Oil Glycereth-8 Ester, Babassu Acid, Babassuamide Propylamine Oxide, Babassuamidopropyl Betaine, Beeswax Acid, Behenamidopropyl Dopyl Betaine, Behenamine Oxide, Beheneth-25, Beheneth-30, Behenic Acid, Behenyl Betaine, Bis-Butyl Dimethicone Polyglyceryl-3, Butoxynol-5 Caprylic / Capric Triglyceride Carboxylic acid, butoxynol-19 carboxylic acid, butyldimonium hydroxypropyl butyl Lauryl Glucoside Chloride, Butyldimonium Hydroxypropyl Lauryl Glucoside Chloride Butyl glucoside, capric acid butyl glucoside, butyl glucoside hydroxypropyl Pyrtrimonium chloride, butyl octanoic acid, C18-36 acid, C20-40 acid, C3 0-50 acid, C16-22 acid amide MEA, calcium dodecylbenzenesulfonate, Calcium uroyl taurate, C9-16 alkane / cycloalkane, C10-14 alkane Alkylbenzenesulfonic acid, C12-14 alkyldiaminoethylglycine HCl, C9 -15 Alkyl Phosphate, Candida Bombicola / Glucose / Nata Fermented oil fatty acid methyl ester, Canolamidoppropyl betaine (Canolamidop ropyl Betaine), Capric Acid, Caproic Acid, Caproyl Ethyl Glucoside , (Capryl / Capramido)propyl Betaine, Capryleth-4 Carboxylic Acid, Capryleth -6 carboxylic acid, capryleth-9 carboxylic acid, caprylic acid, capryloyl collagen amino Capryloyl Glycine, Capryloyl Hydrolyzed Collagen, Capryloyl Hydrolyzed Keratin, Capryloyl Keratin Amino Acids, Capryloyl Silk Amino Acids, Caprylyl / Capryl Glucoside, Caprylyl / Capryl Wheat Bran / Straw Glycoside, Caprylic Caprylyl Glucoside, Caprylyl Glyceryl Ether, Caprylyl Pyrrolidone, Carnitine, Ceteareth-20, Ceteareth-23, Ceteareth-24, Ceteareth-25, Ceteareth Ceteareth-27, Ceteareth-28, Ceteareth-29, Ceteareth-30, Ceteareth-33 , Ceteareth-34, Ceteareth-40, Ceteareth-50, Ceteareth-55, Ceteareth Ceteareth-60, Ceteareth-80, Ceteareth-100, Ceteareth-25 carboxylic acid, Teareth-2 phosphate, ceteareth-4 phosphate, ceteareth-5 phosphate, ceteareth-10 Phosphate, Ceteth-20, Ceteth-23, Ceteth-24, Ceteth-25, Ceteth-30, Ceteth Ceteth-40, Ceteth-45, Ceteth-150, Ceteth-8 phosphate, Ceteth-10 phosphate, Ceteth-20 phosphate, ceteth-22, ceteth-24, ceteth-25, ceteth-3 0, Cetyl Betaine, Chrysanthemum Sinense Flower Extract, C12- 14 Hydroxyalkyl Hydroxyethyl Beta-Alanine, C12-14 Hydroxya Alkylhydroxyethyl sarcosine, cocamidoethyl betaine, cocamidopropylamine Oxide, Cocamidopropyl Betaine Amide MEA Chloride, Cocamidopropyl Betaine , Cocamidopropyl Hydroxysultaine, Oxidized Cocamine, Cocaminobutyric Acid, Cocaminopropyl Pionic acid, coceth-7 carboxylic acid, coceth-4 glucoside, cocoamphodipropionic acid, Cocobetaine Amido Amphopropionate, Coco-Betaine, Cocodimonium Hydroxide Propyl Hydrolyzed Rice Protein, Cocodimonium Hydroxypropyl Hydrolyzed Soy Protein Protein, Cocodimonium Hydroxypropyl Hydrolyzed Wheat Protein, Coco-Glucoside Coco-Glucoside Hydroxypropyltrimonium Chloride, Coco-Hydroxysulfur Tine, Coco-Morpholine Oxide, Palm Fatty Acids, Palm Oil Glycereth-8 Ester, Coco / Oleamidopropyl Betaine, Coco-Sultaine, Coco / Sunflower Amidopropyl Betaine Cocoyl choline methosulfate, cocoyl glutamate, cocoyl hydrolyzed choline Protein, Cocoyl Hydrolyzed Keratin, Cocoyl Hydrolyzed Oat Protein, Cocoyl Hydrolyzed rice protein, cocoyl hydrolyzed silk, cocoyl hydrolyzed soy protein , Cocoyl Hydrolyzed Wheat Protein, Cocoyl Sarcosine, Corn Acid, Cottonseed Acid, Cottonseed Oil Glycereth-8 ester, C10-16 Pareth-1, C10-16 Pareth-2, C11- 13 Palace-6, C11-13 Palace-9, C11-13 Palace-10, C11-15 Palace Palace-30, C11-15 Palace-40, C12-13 Palace-1, C12-13 Palace -23, C12-14 Palace-5, C12-14 Palace-9, C13-15 Palace-21 , C14-15 Palace-8, C20-22 Palace-30, C20-40 Palace-40, C 20-40 Palace-95, C22-24 Palace-33, C30-50 Palace-40, C9 -11 Palace-6 carboxylic acid, C9-11 Palace-8 carboxylic acid, C11-15 Palace- 7 carboxylic acids, C12-13 Pareth-5 carboxylic acids, C12-13 Pareth-7 carboxylic acids , C12-13 Pareth-8 carboxylic acid, C12-13 Pareth-12 carboxylic acid, C12- 15 Pareth-7 Carboxylic Acid, C12-15 Pareth-8 Carboxylic Acid, C12-15 Pareth- 12 carboxylic acids, C14-15 pareth-8 carboxylic acids, C6-10 pareth-4 phosphates, C 12-13 Pareth-2 Phosphate, C12-13 Pareth-10 Phosphate, C12-15 Pareth- 6 phosphate, C12-15 Pareth-8 phosphate, C12-15 Pareth-10 phosphate, C12- 16-Paleth-6 Phosphate, C4-18 Perfluoroalkylethylthiohydroxypropyl Trimonium Chloride, Cupuasamidopropyl Betaine, DEA-C12-13 Alkyl DEA-C12-15 Alkyl Sulfate, DEA-Ceteareth-2 Phosphate, DEA-Cetyl Sulfate, DEA-Cocoamphodipropionate, D EA-C12-13 Pareth-3 Sulfate, DEA-Cyclocarboxypropyl Oleate DEA-Dodecylbenzenesulfonate, DEA-Isostearate, DEA-Lactic Acid DEA-Ureth Sulfate, DEA-Lauryl Sulfate, DEA-Linoleate, DEA- Methyl Myristate Sulfonate, DEA-Myreth Sulfate, DEA-Myristate , DEA-myristyl sulfate, DEA-oleth-5 phosphate, DEA-oleth -20 Phosphate, DEA PG-Oleate, Deceth-7 Carboxylic Acid, Deceth-7 Glycerol Lucoside, Deceth-9 Phosphate, Decylamine oxide, decylbetaine, decylglucoside, decyltetradeceth-30 , decyltetradecylamine oxide, lauramide-MEA, diammonium sulfosuccinate , Lauryl Sulfosuccinate Diammonium, Oleamide PEG-2 Sulfosuccinate Diammonium ammonium, dibutoxymethane, di-C12-15 palladium-2 phosphate (Di-CI 2- 15 Pareth-2 Phosphate), Di-C12-15 Pareth-4 Phosphate, Di-C12-15 Pareth-6 Phosphate, Di-C12-15 Pareth-8 Phosphate, Di-C12- 15-Palace-10 Phosphate, Didodecyl Butanetetracarboxylate, Diethyl Laureth Sulfate Mine, Diethylhexyl Sodium Sulfosuccinate, Dihydroxyethyl C8-10 Alkyl C9-11 alkoxypropylamine oxide, dihydroxyethyl C9-11 alkoxypropylamine Dihydroxyethyl C12-15 alkoxypropylamine oxide, dihydroxyethyl C12-15 alkoxypropylamine oxide Hydroxyethyl cocamine oxide, dihydroxyethyl lauramine oxide, dihydroxy Diethylstearamine oxide, dihydroxyethyl tallowamine oxide, dimethicone P EG-7 Phosphate, Dimethicone PEG-10 Phosphate, Dimethicone PEG / PP G-7 / 4 Phosphate, Dimethicone PEG / PPG-12 / 4 Phosphate, Dimethicone / Polyphosphate Diglycerin-3 cross-linked polymer, dimethicone propyl PG-betaine, dimyristyl phosphate oleyl, dioleylamidoethyl hydroxyethylmonium methosulfate, hydrogenated coconut fat Acid DIPA, Lanolin Fatty Acid DIPA, Myristic Acid DIPA, Capryloyl Glutamine Dipotassium Lauryl Sulfosuccinate, Dipotassium Lauryl Sulfosuccinate, Dipotassium Undecynoyl Glutamate Um, Babassuamide MEA-Disodium Sulfosuccinate, Disodium Caproamphodiacetate Um, Caproamphodipropionate Disodium, Capryloamphodiacetate Disodium, Disodium capryloamphodipropionate, disodium capryloyl glutamate, Disodium Cetearyl Sulfosuccinate, Disodium Cetyl Phenyl Ether Disulfonate Cetyl Sulfosuccinate Disodium, Cocamide MEA-Sulfosuccinate Disodium Cocamide MIPA PEG-4 Disodium Sulfosuccinate, Cocamide MIPA-S Disodium sulfosuccinate, Cocamide PEG-3 disodium sulfosuccinate, Coceth- 3 Disodium Sulfosuccinate, Cocoamphocarboxyethyl Hydroxypropyl Sulfo Disodium Cocoamphodiphosphate, Disodium Cocoamphodiacetate, Disodium Cocoamphodipropionate Coco-glucoside sulfosuccinate disodium, coco-sulfosuccinate disodium Cocoyl butyl gluceth-10 disodium sulfosuccinate, cocoyl glutamic acid Disodium, C12-14 Pareth-1 Disodium Sulfosuccinate, C12-14 Pareth Disodium C12-15 sulfosuccinate, Disodium C12-15 sulfosuccinate, C12-14 Sec-Palace-3 Disodium Sulfosuccinate, C12-14 Sec -Pareth-5 Disodium Sulfosuccinate, C12-14 Sec-Pareth-7 Sulfoco Disodium succinate, C12-14 Sec-Palace-9 Disodium Sulfosuccinate, C12-14 Sec-Palace-12 Disodium Sulfosuccinate, Deceth-5 Disodium Sulfosuccinate, Deceth-6 Disodium Sulfosuccinate, Deceth-6 Disodium phenyl ether disulfonate, Dihydroxyethyl sulfosuccinylunsulfonate Disodium Decylenate, Ethylenedicocamide PEG-15 Disodium Disulfate, Hydrogenated Cottonseed glyceride disodium sulfosuccinate, hydrogenated beef tallow disodium glutamate, Hydroxydecyl sorbitol disodium citrate, isodecyl disodium sulfosuccinate Um, Isostearamid MEA-Disodium Sulfosuccinate, Isostearamid MIP A-Disodium sulfosuccinate, disodium isostearoamphodiacetate, isostearoyl Disodium Isostearyl Sulfosuccinate, Disodium Isostearyl Sulfosuccinate, Nes-5 Disodium Sulfosuccinate, Lauramide MEA-Disodium Sulfosuccinate , Lauramide MIPA Glycol Sulfosuccinate Disodium, Lauramide PEG-2 Sulfosuccinate Disodium sulfosuccinate, Lauramide PEG-5 Disodium sulfosuccinate, Lauryl Disodium Laureth-5 Carboxyamphodiacetate, Disodium Laureth-7 Citrate, Laureth Disodium Laureth Sulfosuccinate, Disodium Laureth-6 Sulfosuccinate, Laureth -9 Disodium Sulfosuccinate, Laureth-12 Disodium Sulfosuccinate, Lauryl Disodium minobishydroxypropylsulfonate, disodium lauriminodiacetate, Disodium lauriminodipropionate, Tocopheryl lauriminodipropionate phosphate Disodium, Disodium Lauroamphodiacetate, Disodium Lauroamphodipropionate Disodium N-lauroyl aspartate, disodium lauroyl glutamate Disodium lauryl phenyl ether disulfonate, disodium lauryl sulfosuccinate Sodium, Myristamide MEA-Disodium Sulfosuccinate, Nonoxynol-10 Disodium sulfosuccinate, oleamide MEA-Disodium sulfosuccinate, oleamide Disodium PEG-2 sulfosuccinate, Oleamide PEG-2 disodium sulfosuccinate Sodium, Disodium Oleoamphodipropionate, Disodium Oleth-3 Sulfosuccinate Disodium oleyl phosphate, disodium oleyl sulfosuccinate, palmitate Disodium PEG-2 Sulfosuccinate, Palmitoleamide PEG-2 Sulfosuccinate Disodium Sulfosuccinate, PEG-4 Cocamide MIPA- Disodium Sulfosuccinate, PEG- 12 Dimethicone Disodium Sulfosuccinate, PEG-8 Palm Glycerides Sulfosuccinate Disodium Carboxyamphodiacetate, PPG-2-Isodeceth-7 Disodium Carboxyamphodiacetate, Cinoleamide MEA-Disodium Sulfosuccinate, Sitosterol-14 Sulfosuccinate Disodium, Soybean Amphodiacetate Disodium, Stearamide MEA-Sulfosuccinate Disodium, Disodium stearaminodipropionate, Disodium stearaminodiacetate Sodium, Disodium Stearoyl Glutamate, Disodium Stearyl Sulfosuccinate , disodium stearyl sulfosuccinate, disodium 2-sulfolaurate, 2- Disodium Sulfopalmitate, Beef Tallowamide MEA-Disodium Sulfosuccinate, Beef Fatty amide MEA-disodium sulfosuccinate, beef tallow amphodiacetate disodium, beef tallow Disodium minodipropionate, disodium beef tallow sulfosuccinate, tridecyl sulfonate Disodium succinate, Undecylenamide MEA-Disodium sulfosuccinate, Un Decyleneamide PEG-2 Disodium Sulfosuccinate, Undecylenoyl Glutamate Disodium, Wheat germ amide MEA-disodium sulfosuccinate, wheat germ amide PEG-2 sulfosuccinate Disodium sulfosuccinate, Wheat germ amphodiacetate disodium, Di-TEA-cocamidopropyl betaine Diacetate, Di-TEA-oleamide PEG-2 sulfosuccinate, Di-TEA- Palmitoyl aspartate, ditridecyl sodium sulfosuccinate, dodecylbene Diazenesulfonic Acid, Erucamidopropyl Hydroxysultaine, Ethylhexyl-3 Carboxylate Acid, Ethyl PEG-15 Cocamine Sulfate, Glyceryl Caprylyl Ether, Hexyl Decanoic Acid, Hydrogenated Palm Fatty Acid, Hydrogenated Laneth-25, Hydrogenated Menhaden Acid, Hydrogenated Palm Oil fatty acids, hydrogenated palm kernel amine oxide, hydrogenated tallow acid, hydrogenated tallow amine oxide, Hydrogenated Tallow Betaine, Hydrogenated Tallow Oil-25, Hydrogenated Tallow Oil Glutamate, Hydrogenated Decomposed Candida Bombicola Extract, Hydroxyceteth-60, Hydroxy Ethylacetemonium PG-Dimethicone, Hydroxyethylbutylamine Laureth Sulfate ate, hydroxyethyl carboxymethyl cocamidopropylamine, hydroxyethyl Hydroxypropyl C12-15 Alkoxypropylamine Oxide, Hydroxylauric Acid Hydroxymyristyl betaine, hydroxystearic acid, hydroxysuccinimide C10-40 isoalkyl acidate, hydroxysuccinimidyl C21-22 isoalkyl acidate Soybean alkyl acidate, hydroxysultaine, IPDI / PEG-15 soy amine oxide copolymer, IPDI / PEG-15 soyethonium ethosulfate copolymer , IPDI / PEG-15 soy glycinate copolymer, isoceteth-30, isolatol Res-4 Phosphate, Isopolyglyceryl-3 Dimethicone, Isopolyglyceryl-3 Dimethicone N-hydroxybenzoate, isopropanolamine lanolate, isopropyl dodecylbenzenesulfonate Amine, Isostearamidopropylamine oxide, Isostearamidopropyl betaine , Isostearamidopropyl morpholine oxide, Isosteareth-8, Isosteareth -16, Isosteareth-22, Isosteareth-25, Isosteareth-50, Isos Stearic acid, isostearoyl hydrolyzed collagen, jojoba oil PEG-150 ester, Jojoba Wax PEG-80 Ester, Jojoba Wax PEG-120 Ester, Laneth -20, Lanes-25, Lanes-40, Lanes-50, Lanes-60, Lanes-75, La Nori Acid, Lauramidopropylamine Oxide, Lauramidopropyl Betaine, Laurami Dopropyl Hydroxysultaine, Lauramine Oxide, Lauraminopropionic Acid, Lauryl Sulfate Laurdimonium Hydroxypropyldecyl Glucoside Chloride, Laurdimonium Hydroxide Dipropyl Lauryl Glucoside Chloride, Laureth-16, Laureth-20, Laureth- 21, Laureth-23, Laureth-25, Laureth-30, Laureth-38, Laureth- 40, Laureth-3 Carboxylic Acid, Laureth-4 Carboxylic Acid, Laureth-5 Carboxylic Acid, La Laureth-6 carboxylic acid, laureth-8 carboxylic acid, laureth-10 carboxylic acid, laureth -11 carboxylic acid, laureth-12 carboxylic acid, laureth-13 carboxylic acid, laureth- 14 Carboxylic Acid, Laureth-17 Carboxylic Acid, Laureth-6 Citric Acid, Laureth-7 Quercus Phosphate, Laureth-1 Phosphate, Laureth-2 Phosphate, Laureth-3 Phosphate, Laureth-4 Phosphate Laureth-7 Phosphate, Laureth-8 Phosphate, Laureth-7 Tartaric Acid, Lauric Acid (L aurie Acid), Lauriminobispropanediol, Lauriminodipropionic Acid , Lauroamphodipropionic Acid, Lauroyl Beta-Alanine, Lauroyl Collagen Amino Lauroyl ethyltrimonium methosulfate, lauroyl hydrolyzed collagen , lauroyl hydrolyzed elastin, lauroyl methyl glucamide, lauroyl sarcosine , Lauroyl Silk Amino Acids, Lauryl Betaine, Lauryl Dimethicone / Polyglycerin -3 crosslinked polymer, lauryldimonium hydroxypropyl cocoglucoside chloride, Lauryl glucoside, lauryl glucoside hydroxypropyltrimonium chloride, lauryl glucoside Lauryl glycol hydroxypropyl ether, lauryl hydroxysultaine, lauryl Malamide, Lauryl Methyl Glucamide, Lauryl / Myristyl Glycol Hydroxypropyl Pyr Ether, Lauryl / Myristyl Wheat Bran / Straw Glycosides, Lauryl Poly Glyceryl-3 Polydimethylsiloxyethyl Dimethicone, Lauryl Pyrrolidone, Lauryl Sultaine, linoleic acid, linolenic acid, flaxseed fatty acid, coconut fatty acid lysine, macadamia seed Child oil glyceryl-8 ester, magnesium coceth sulfate, magnesium cocos sulfate, Magnesium isododecylbenzenesulfonate, magnesium laureth-11 carboxylate , Magnesium Laureth Sulfate, Magnesium Laureth-5 Sulfate, Magnesium Laureth-8 Sulfate Sodium, Laureth-16 Magnesium Sulfate, Laureth-3 Magnesium Sulfosuccinate, Magnesium Lauryl Hydroxypropyl Sulfonate, Magnesium Lauryl Sulfate, Coco Magnesium methyl taurate, magnesium myristyl sulfate, magnesium oleth sulfate, Coco-Alkyl Sulfate (Mg / TEA), Manicouagan Clay, MEA-Cocoate, MEA -Laureth-6 Carboxylate, MEA-Laureth Sulfate, MEA-Lauryl Laureth-7 Carboxylate, MEA-PPG-8- Steareth-7 carboxylate, MEA-undecylenate, meroxapol 108, Meroxapol 174, Meroxapol 178, Meroxapol 254, Meroxapol 255, Meroxapol 258, Meroxapol 314, Methoxy PEG-450 Amide Glutaroyl succinimide, methoxy PEG-450 amido hydroxysuccinimide Persuccinate, Methoxy PEG-450 Maleimide, Methylmorpholine Oxide, Methyl Mikamidopropylamine oxide, Mikamidopropyl betaine, Mikamidopropyl Aminopropylamine Oxide, Mincamidopropyl Betaine, MIPA C12-15 Parethsul Phosphate, MIPA-Dodecylbenzenesulfonate, MIPA-Laureth Sulfate , MIPA-Lauryl Sulfate, Mixed Isopropanolamine Lauryl Sulfate, Mixed Isopropanolamine Lauryl Sulfate Propanolamine lauryl sulfate, mixed isopropanolamine myristate, Morpholine oleate, morpholine stearate, myreth-3 carboxylic acid, myreth-5 carboxylic acid Carboxylic acid, myristalkonium chloride, myristamidopropylamine oxide, myristalkonium Tamidopropyl Betaine, Myristamidopropyl Dimethylamine Phosphate, Myristamidopropyl Myristamidopropyl PG-dimonium chloride Sulfate, Myristamine Oxide, Myristaminopropionic Acid, Myristic Acid, Myris Toylethyltrimonium methosulfate, Myristoyl glutamic acid, Myristoyl Hydrolyzed Collagen, Myristoyl Sarcosine, Myristyl Betaine, Myristyl / Cetyl Aminomethyl Propanol, Myristyldimonium Hydroxypropyl Cocoglucoside Chloride, Myristyl glucoside, myristyl phosphate, nonoxynol-20, nonoxynol-2 3. Nonoxynol-25, Nonoxynol-30, Nonoxynol-35, Nonoxynol Nonoxynol-40, Nonoxynol-44, Nonoxynol-50, Nonoxynol-100, Nonoxynol-120, Nonoxynol-5 Carboxylic Acid, Nonoxynol-8 Carboxylic Acid Acid, Nonoxynol-10 Carboxylic Acid, Nonoxynol-3 Phosphate, Nonoxynol Nonoxynol-4 phosphate, nonoxynol-6 phosphate, nonoxynol-9 phosphate Nonoxynol-10 phosphate, Nonylnonoxynol-30, Nonylnonoxynol-49, Nonylnonoxynol-1 00, Nonylnonoxynol-150, Nonylnonoxynol-7 phosphate, Nonyl Nonoxynol-8 phosphate, nonylnonoxynol-9 phosphate, nonylnonoxynol Xynol-10 phosphate, nonylnonoxynol-11 phosphate, nonylnonoxynol Xynol-15 phosphate, nonylnonoxynol-24 phosphate, oat Amidopropyl Betaine, Octoxynol-16, Octoxynol-25, Octoxy Octoxynol-30, Octoxynol-33, Octoxynol-40, Octoxynol -70, Octoxynol-20 carboxylic acid, Octyldodeceth-20, Octyldodeceth Oleamidopropylamine oxide, ole ... Propyl Betaine, Oleamidopropyl Hydroxysultaine, Oleamine Oxide, Ole Acid, Oleoyl Hydrolyzed Collagen, Oleoyl Sarcosine, Oleth-20, Oleth -23, Oleth-24, Oleth-25, Oleth-30, Oleth-35, Oleth-40, Oleth- Oleth-44, Oleth-50, Oleth-3 carboxylic acid, Oleth-6 carboxylic acid, Oleth-1 0 carboxylic acid, oleyl betaine, olivamidopropylamine oxide, olivamidopropyl Pyrbetaine, Olive Oil Fatty Acids, Olive Oil Fatty Acid Hydrolyzed Wheat Protein, Oph Iopogon Extract Stearate, Ozonated Oleth-10, Ozonated PEG Oleate -10, Ozonated PEG-14 Oleate, Ozonated Polysorbate 80, Palm Oil Fat Acid, Palmamidopropyl Betaine, Palmeth-2 Phosphate, Palmitamidopropylamine Oxide, Palmitamidopropyl Betaine, Palmitamine Oxide, Palmitic Acid, Palm Palmitoyl collagen amino acids, palmitoyl glycine, palmitoyl hydrolyzed collagen , palmitoyl hydrolyzed milk protein, palmitoyl hydrolyzed wheat protein, palmitoyl Palmitoyl keratin amino acid, palmitoyl oligopeptide, palmitoyl silk amino acid, Palm kernel fatty acid, palm kernel amidopropyl betaine, peach kernel oil glycereth-8 ester, Peanut Oil Fatty Acids, PEG-10 Castor Oil, PEG-40 Castor Oil, PEG-44 Castor Castor Oil, PEG-50 Castor Oil, PEG-54 Castor Oil, PEG-55 Castor Oil, PEG- 60 Castor Oil, PEG-80 Castor Oil, PEG-100 Castor Oil, PEG-200 Castor Oil Oil, PEG-11 Cocamide, PEG-6 Cocamide Phosphate, PEG-4 Cocamine, P EG-8 Cocamine, PEG-12 Cocamine, PEG-150 Dibehenate, PEG-90 Diisostearate, PEG-75 Dilaurate, PEG-150 Dilaurate, PEG -75 Dioleate, PEG-150 Dioleate, PEG-75 Distearate, PE G-120 Distearate, PEG-150 Distearate, PEG-175 Distearate PEG-190 Distearate, PEG-250 Distearate, PEG-30 Distearate Lyceryl Cocoate, PEG-40 Glyceryl Cocoate, PEG-78 Glyceryl Cocoate Etate, PEG-80 Glyceryl Cocoate, PEG-30 Glyceryl Isostearate , PEG-40 Glyceryl Isostearate, PEG-50 Glyceryl Isostearate , PEG-60 Glyceryl Isostearate, PEG-90 Glyceryl Isostearate , PEG-23 glyceryl laurate, PEG-30 glyceryl laurate, PEG-25 Glyceryl Oleate, PEG-30 Glyceryl Oleate, PEG-30 Glyceryl soyate, PEG-25 glyceryl stearate, PEG-3 stearate 0 Glyceryl Stearate, PEG-40 Glyceryl Stearate, PEG-120 Glyceryl Stearate Ceryl, PEG-200 Glyceryl Stearate, PEG-28 Glyceryl Tallowate, PEG-80 tallow fatty acid glyceryl, PEG-82 tallow fatty acid glyceryl, PEG-13 0 Glyceryl Tallowate, PEG-200 Glyceryl Tallowate, PEG-45 Hydrogenated Castor Oil Castor Oil, PEG-50 Hydrogenated Castor Oil, PEG-54 Hydrogenated Castor Oil, PEG-55 Hydrogenated Castor Oil Oil, PEG-60 Hydrogenated Castor Oil, PEG-80 Hydrogenated Castor Oil, PEG-100 Hydrogenated Castor Oil Oil, PEG-200 Hydrogenated Castor Oil, PEG-30 Hydrogenated Lanolin, PEG-70 Hydrogenated Lanolin PEG-50 Hydrogenated Palmamide, PEG-2 Isostearate, P Isostearate EG-3, PEG-4 Isostearate, PEG-6 Isostearate, Isostearin PEG-8 Isostearate, PEG-10 Isostearate, PEG-12 Isostearate, Isostearate PEG-20 stearate, PEG-30 isostearate, PEG-4 isostearate 0, Jojoba Fatty Acid PEG-26, Jojoba Fatty Acid PEG-40, PEG-15 Jojoba Alcohol Alcohol, PEG-26 Jojoba Alcohol, PEG-40 Jojoba Alcohol, PEG-35 La Lanolin, PEG-40 Lanolin, PEG-50 Lanolin, PEG-55 Lanolin, PEG -60 Lanolin, PEG-70 Lanolin, PEG-75 Lanolin, PEG-85 Lanolin , PEG-100 Lanolin, PEG-150 Lanolin, PEG-75 Lanolin Oil, PEG -2 Lauramide, PEG-3 Lauramine Oxide, PEG-20 Laurate, Lauric Acid PEG-32, PEG-75 Laurate, PEG-150 Laurate, PEG-70 Mannan Glycerides, PEG-20 Mannitan Laurate, PEG-8 Methyl Ether Dimethicone Con, PEG-120 methyl glucose dioleate, PEG-80 methyl glucose laurate Urates, PEG-120 Methyl Glucose Trioleate, PEG-4 Montanol, P EG-30 Oleamine, PEG-20 Oleate, PEG-23 Oleate, Oleic Acid PEG-32, PEG-36 oleate, PEG-75 oleate, PEG- 150, PEG-20 Palmitate, PEG-150 Polyglyceryl Tristearate 2. PEG / PPG-28 / 21 Dimethicone Acetate, PEG / PPG-24 / 18 Butyl Ester Dimethicone, PEG / PPG-3 / 17 copolymer, PEG / PPG-5 / 35 copolymer Polymer, PEG / PPG-8 / 55 copolymer, PEG / PPG-10 / 30 copolymer -, PEG / PPG-10 / 65 copolymer, PEG / PPG-12 / 35 copolymer, PEG / PPG-16 / 17 copolymer, PEG / PPG-20 / 9 copolymer, PEG / PPG-20 / 20 copolymer, PEG / PPG-20 / 60 copolymer, PEG / P PG-20 / 65 copolymer, PEG / PPG-22 / 25 copolymer, PEG / PPG -28 / 30 copolymer, PEG / PPG-30-35 copolymer, PEG / PPG-3 0 / 55 copolymer, PEG / PPG-35 / 40 copolymer, PEG / PPG-50 / 40 copolymer, PEG / PPG-150 / 35 copolymer, PEG / PPG-160 / 30 copolymer, PEG / PPG-190 / 60 copolymer, PEG / PPG-200 / 40 copolymer, PEG / PPG-300 / 55 copolymer, PEG / PPG-20 / 2 2-Methyl Ether Dimethicone, PEG-26-PPG-30 Phosphate, PEG / PPG-4 / 2 propylheptyl ether, PEG / PPG-6 / 2 propylheptyl ether, PEG-7 / PPG-2 propyl heptyl ether, PEG / PPG-8 / 2 propyl heptyl ether Propyl ether, PEG / PPG-10 / 2 propylheptyl ether, PEG / PPG -14 / 2 Propylheptyl Ether, PEG / PPG-40 / 2 Propylheptyl Ether Tere, PEG / PPG-10 / 2 ricinoleate, PEG / PPG-32 ricinoleate / 3, PEG-55 Propylene Glycol Oleate, PEG-25 Propylene Glycol Stearic Acid, PEG-75 Propylene Glycol Stearate, PEG-120 Propylene Glycol Stearate Pyrene glycol sorbitan laurate, PEG-5 rapeseed sterol, PEG-10 rapeseed oil Tanesterol, PEG-40 Ricinoleamide, PEG-75 Shea Butter Glycerides, PEG-75 Shorea Butterglycerides, PEG-20 Sorbitan Cocoate, Isopropyl Myristate PEG-20 Sorbitan Isostearate, PEG-40 Sorbitan Lanolinate, Lanolin PEG-75 sorbitan phosphate, PEG-10 sorbitan laurate, P laurate EG-40 sorbitan, PEG-44 sorbitan laurate, PEG-75 sorbitan laurate Sorbitan, PEG-80 Sorbitan Lauryl, PEG-20 Sorbitan Oleate, P EG-80 sorbitan palmitate, PEG-40 sorbitan stearate, stearin PEG-60 Sorbitan Triisostearate, PEG-160 Sorbitan Triisostearate, PEG- 40 soybean sterols, PEG-2 stearamide carboxylic acid, PEG-9 stearamide Carboxylic Acid, PEG-20 Stearate, PEG-23 Stearate, PEG Stearate -25, PEG-30 stearate, PEG-32 stearate, PEG- 35, PEG-36 Stearate, PEG-40 Stearate, PEG-4 Stearate 5. PEG-50 Stearate, PEG-55 Stearate, PEG-75 Stearate , PEG-90 Stearate, PEG-100 Stearate, PEG-12 Stearate 0, PEG-150 Stearate, PEG-45 Stearate Phosphate, PEG-2 0 Tallowate, PEG-50 Tallowamide, PEG-2 Tallowamide DEA, PEG-20 Tallow Weight, PEG-66 trihydroxystearin, PEG-200 trihydroxystearin Alin, Camellia oil fatty acid PEG-60 glyceride, pelargonic acid, pentadoxynol 200, Phenes-6 Phosphate, Poloxamer 105, Poloxamer 108, Poloxamer Poloxamer 182, Poloxamer 183, Poloxamer 184, Poloxamer 188, Poloxamer Poloxamer 217, Poloxamer 234, Poloxamer 235, Poloxamer 237, Poloxamer Poloxamer 238, Poloxamer 288, Poloxamer 334, Poloxamer 335, Poloxamer Summer 338, Poloxamine 908, Poloxamine 1508, Polydimethylsiloxane P EG / PPG-24 / 19 butyl ether silsesquioxane, polydimethylsiloxane PPG-13 Butyl Ether Silsesquioxane, Polyglyceryl-6 Caprate, Zilla Polyglyceryl-10 Heptacaprylate, Polyglyceryl-20 Heptacaprylate, Hexacaprylate Polyglyceryl-20 Lauryl Ether, Polyglyceryl-2 Lauryl Ether, Polyglyceryl-1 0 Lauryl Ether, Polyglyceryl-20 Octaisononanoate, Polyglyceryl-6 Phenoxyethanol Pentacaprylate, Polyglyceryl-10 Pentacaprylate, Polyglyceryl-3 Poly Dimethylsiloxyethyl Dimethicone, Polyglyceryl-6 Tetracaprylate, Tetralauroyl Palmitate Polyglyceryl-10 Phosphate, Polyglyceryl-6 Tricaprylate, Polyglyceryl Trilaurate Glyceryl-10, Polyquaternium-77, Polyquaternium-78, Polyquaternium Mu-79, Polyquaternium-80, Polyquaternium-81, Polyquaternium-82 , Pomaderis Kumerahou Flower / Leaf Extract, Poria Cocos Extract Extract, potassium abietoyl hydrolyzed collagen, potassium babasuate, Potassium Behenate, Potassium C9-15 Alkyl Phosphate, Potassium C11-15 Alkyl Phosphate Alkyl Phosphate, Potassium C12-13 Alkyl Phosphate, Potassium C12-1 4 alkyl phosphate, potassium caprate, potassium capryloyl glutamate, Sodium Capryloyl Hydrolyzed Rice Protein, Potassium Castor Oil Fatty Acids, Potassium Cocoate Cocoyl glutamate, potassium cocoyl glycine, cocoyl hydrolyzed calcium Potassium zeinate, potassium cocoyl hydrolyzed collagen, cocoyl hydrolyzed corn Potassium protein, potassium cocoyl hydrolyzed keratin, cocoyl hydrolyzed oat Potassium Protein, Cocoyl Hydrolyzed Potassium Protein, Cocoyl Hydrolyzed Potassium Protein Hydrolyzed rice bran protein potassium, cocoyl hydrolyzed rice protein potassium, cocoyl hydrolyzed rice protein potassium Hydrolyzed silk potassium, cocoyl hydrolyzed soy protein potassium, cocoyl hydrolyzed Wheat Protein Potassium, Cocoyl Hydrolyzed Yeast Protein Potassium, Cocoyl PCA Potassium, potassium cocoyl sarcosinate, potassium cocoyl taurate, potassium corn , potassium cyclocarboxypropyl oleate, potassium dihydroxyethyl cocamidopropyl betaine Polyquaternium-100, Triethoxycaprylylsilane, Sodium Benzoate, Potassium Chloride, Dimethicone PEG-7 Phosphate, Dodecyl Benzyl Alcohol Potassium Benzene Sulfonate, Potassium Hemp Seed Oate, Potassium Hydrogenated Coconut Fatty Acid, Partially Water Potassium palm oil fatty acid, partially hydrogenated potassium tallow fatty acid, potassium hydroxystearate Calcium, Potassium Isostearate, Potassium Lanolinate, Potassium Laurate, Lauryl Sulfate Potassium Laureth-3 Carboxylate, Potassium Laureth-4 Carboxylate, Laureth-5 Carvone Potassium Laureth-6 Carboxylate, Potassium Laureth-10 Carboxylate, La Potassium urethrate, potassium lauroyl collagen amino acid, lauroyl glutamine Potassium Lauroyl Hydrolyzed Collagen, Potassium Lauroyl Hydrolyzed Enol Dough Protein, Potassium Lauroyl Hydrolyzed Soy Protein, Potassium Lauroyl P CA, potassium lauroyl pea amino acid, potassium lauroyl sarcosinate, Sodium Lauroyl Silk Amino Acids, Potassium Lauroyl Wheat Amino Acids, Lauryl Phosphate Potassium, potassium lauryl sulfate, potassium linoleate, potassium metaphosphate, cocoyl Potassium methyl taurate, potassium myristate, potassium myristoyl glutamate, Potassium myristoyl hydrolyzed collagen, potassium octoxynol-12 phosphate, Potassium leate, potassium oleoyl hydrolyzed collagen, potassium olive oil fatty acids , Olive oil fatty acid hydrolyzed oat protein potassium, Olive oil fatty acid hydrolyzed Wheat Protein Potassium, (Olive Oil Fatty Acid / Lauroyl) Wheat Amino Acid Potassium , Olive oil fatty acid potassium PCA, palm fatty acid potassium, palmitic acid potassium, Sodium palmitoyl hydrolyzed corn protein, potassium palmitoyl hydrolyzed calcium Wheat Protein, Potassium Palmitoyl Hydrolyzed Rice Protein, Potassium Palmitoyl Hydrolyzed Sweet Almond Protein, Potassium Palmitoyl Hydrolyzed Wheat Protein Protein, palm kernel fatty acid potassium, peanut oil fatty acid potassium, rapeseed oil fatty acid potassium , potassium ricinoleate, potassium safflower oil fatty acid, potassium soybean oil fatty acid, ste Potassium allate, potassium stearate, potassium stearoyl hydrolyzed collagen, Potassium tallowate, potassium tallowate, potassium taurate, potassium laurate taurine um, trideceth-3 carboxylic acid potassium, trideceth-3 carboxylic acid potassium, trideceth Potassium trideceth-4 carboxylate, potassium trideceth-7 carboxylate, potassium trideceth-15 carboxylate Potassium Carboxylate, Potassium Trideceth-19 Carboxylate, Potassium Trideceth-6 Phosphate , potassium trideceth-7 phosphate, potassium camellia fatty acid, potassium undecylenate, Potassium undecylenoyl hydrolyzed collagen, potassium undecylenoyl hydrolyzed rice Proteins, PPG-30-butes-30, PPG-36-butes-36, PPG-38 -Buteth-37, PPG-30 Capryleth 4 Phosphate, PPG-10 Cetyl Ether Luphosphate, PPG-2 C9-11 Palace-8, PPG-1 Deces-5, PPG -3-Deceth-2 Carboxylic Acid, PPG-30 Ethylhexyl-4 Phosphate, PPG- 20-Glycereth-30, PPG-2 Hydroxyethyl Coco / Isostearamide, PP G-2-Isodeceth-8, PPG-2-Isodeceth-10, PPG-2-Isodeceth-1 8, PPG-2-isodeceth-25, PPG-4-isodeceth-10, Propyltrimonium Hydrolyzed Collagen, Quaternium-24, Quaternium-52, Quaternium-87, rapeseed oil fatty acids, rice bran oil fatty acids, rice oil glyceryl-8 ester Ricinoleamidopropyl Betaine, Ricinoleic Acid, Ricinoleth-40, Safflower Oil Fatty Acids, Sapindus Oahuensis Fruit Extract, Saponaria Officinalis ficinalis root powder, saponin, potassium soap, potassium-containing soap base, soap base, potassium stone Soap base, sesame oil glyceryl-8 ester, sesame propylamine oxide, sesame propylamine Propyl Betaine, Shea Butter Amidopropyl Betaine, Shea Butter Glycereth-8 Este Sodium arachidonate, sodium argan amphoacetate, astrocalcium murum Sodium Fatty Acids, Sodium Avocado Oil Fatty Acids, Sodium Babassu Sulfoacetate, Babassu Sodium bath oil fatty acids, sodium babassu sulfate, sodium behenate, bisglycol Sodium Ricinosulfosuccinate, Sodium Bis-Hydroxyethyl Glycinate Coco -Glucoside cross-linked polymer, sodium bis-hydroxyethylglycinate lauryl- Glucoside cross-linked polymer, boradiamidopropyl PG dimonium chloride sodium phosphate Um, butoxynol-12 sodium sulfate, butyl glucoside hydroxypropyl phosphate Sodium alkane sulfonate, (C13-17) sodium alkanesulfonate, (C14-18) sodium alkanesulfonate Sodium C12-15 Alkoxypropyliminodipropyl Sodium Sulfonate Onates, C10-16 Sodium Alkyl Sulfates, C11-15 Sodium Alkyl Sulfates , C12-13 Sodium Alkyl Sulfate, C12-15 Sodium Alkyl Sulfate, C12 -18 Sodium Alkyl Sulfate, C16-20 Sodium Alkyl Sulfate, C9-22 Alkyl Sodium C14-17 Alkyl Sec Sulfonate, Sodium C14-17 Alkyl Sec Sulfonate, Sodium caprate, sodium caproamphoacetate, caproamphohydroxypropyl Sodium sulfonate, sodium caproamphopropionate, caproyl methyl taurine Sodium Phosphate, Sodium Caprylate, Sodium Capryleth-2 Carboxylate, Caprylic Acid Sodium Res-9 Carboxylate, Sodium Capryloamphoacetate, Capryloamphohydro Sodium Dioxypropyl Sulfonate, Sodium Capryloamphopropionate, Caprylo Sodium Capryloyl Glutamate, Sodium Capryloyl Hydrolyzed Wheat Protein, Caprylic / Capric Triglyceride Sodium Propylene Glycol Sulfonate, Sodium Caprylyl Sulfonate, Sodium Castor Oil Sodium ceteareth-13 carboxylate, sodium cetearyl sulfate, ceteth Sodium 13-carboxylate, Sodium cetyl sulfate, Cocamidopropyl PG-dimonium Sodium muchloridophosphate, sodium cocaminopropionate, sodium coceth sulfate , Sodium Coceth-30 Sulfate, Cocoa Butter Sodium Amphoacetate, Cocoa Butter Fat Sodium Cocoamphoacetate, Sodium Cocoamphoacetate, Sodium Cocoamphohydroxypropylsulfonate Sodium Cocoamphopropionate, Sodium Cocoate, Sodium Cocoate / Babassu / Andiloba Sulfate, Sodium Coco / Babasu Sulfate, Cocoglu Sodium Cocoglucoside Hydroxypropyl Phosphate, Cocoglucoside Hydroxypropyl Sulfo Sodium Phosphate, Coco-Glucoside Sodium Tartrate, Coco-Glyceryl Ether Sulfonate Sodium, Sodium Coco / Hydrogenated Tallow Sulfate, Sodium Cocoiminodiacetate Cocoglyceryl Sulfate, Sodium Coco Monoglyceride Sulfate, Coco Monoglyceride Sulfate Sodium Coco-Propanol, Sodium Coco-PG-Dimonium Chloride Phosphate, Coco-Sulfate Sodium Cocos Sulfoacetate, Sodium Cocoyl Alanine, Sodium Cocoyl Coil amino acids, sodium cocoyl collagen amino acids, sodium cocoyl glutamate Glutamate, Sodium Cocoyl Glutamate, Sodium cocoyl glycinate, (coconut fatty acid / hydrogenated beef tallow fatty acid) sodium glutamate Glucoside, Sodium Cocoyl Hydrolyzed Collagen, Sodium Cocoyl Hydrolyzed Keratin, Sodium cocoyl hydrolyzed rice protein, sodium cocoyl hydrolyzed silk, sodium Sodium cocoyl hydrolyzed soy protein, sodium cocoyl hydrolyzed sweet almonds Wheat Protein, Sodium Cocoyl Hydrolyzed Wheat Protein, Wheat Cocoyl Hydrolyzed Wheat Protein Monosodium Glutamate, Sodium Cocoyl Isethionate, Sodium Cocoate Ilmethylaminopropionate, Sodium Cocoyl Oat Amino Acids, (Palm Fat (Palm Fatty Acid / Sunflower Fatty Acid) Monosodium Glutamate, Sodium Cocoyl Propanol Phosphorus, Sodium Cocoyl Sarcosinate, Sodium Cocoyl Taurate, Cocoyl Threonine Sodium Cocoate, Sodium Cocoyl Glucoside, Wheat Amino Acids, Olefin (C12-14) Sulfate Sodium sulfonate, Sodium olefin (C14-16) sulfonate, Sodium olefin ( Sodium C14-18 sulfonate, Sodium olefin (C16-18) sulfonate Sodium Corn Amphopropionate, Sodium Cottonseed Amphoacetate, C13-15 Pareth-8 Sodium Butyl Phosphate, C9-11 Pareth-6 Sodium Carboxylate, C1 Sodium 1-15 Pareth-7 carboxylate, Sodium C12-13 Pareth-5 carboxylate Sodium C12-13 Pareth-8 Carboxylate, Sodium C12-13 Pareth-12 Carboxylate Sodium Carbonate, C12-15 Pareth-6 Sodium Carbonate, C12-15 Pareth-7 Sodium Carboxylate, C12-15 Pareth-8 Sodium Carboxylate, C14-15 Pareth Sodium Sec-Pareth-8 Carboxylate, C12-14 Sodium Sec-Pareth-8 Carboxylate , C14-15 Pareth-PG Sodium Sulfonate, C12-13 Pareth-2 Sodium Phosphate Thorium, C13-15 Pareth-8 Sodium Phosphate, C9-15 Pareth-3 Sodium Sulfate Um, C10-15 Pareth Sodium Sulfate, C10-16 Pareth-2 Sodium Sulfate, C 12-13 Pares Sodium Sulfate, C12-15 Pares Sodium Sulfate, C12-15 Pares Sodium Pareth-3 Sulfate, C13-15 Sodium Pareth-3 Sulfate, C12-14 Se C-Pareth-3 Sodium Sulfate, C12-15 Pareth-3 Sodium Sulfonate, C12 -15 Pareth-7 Sodium Sulfonate, C12-15 Pareth-15 Sodium Sulfonate , sodium deceth-2 carboxylate, sodium deceth sulfate, decylbenzene sulfone Sodium phosphate, decyl glucoside hydroxypropyl phosphate sodium, decyl glucoside Sodium Hydroxypropyl Sulfonate, Sodium Dilaureth-7 Citrate, Zila Sodium ureth-10 phosphate, sodium dilinoleamidopropyl PG-dimonium chloride Loridophosphate, Sodium Dilinoleate, Sodium Dioleth-8 Phosphate, Dodecyl Sodium Benzene Sulfonate, Sodium Ethyl 2-Sulfolaurate, Sodium Glyceryl Oleate Phosphate, Sodium Grape Seed Amidopropyl PG-Dimonium Chloride Umium chloride phosphate, Grape seed sodium amphoacetate, Grape seed oil fatty acid sodium Sodium, Hemp Seed Amphoacetate, Sodium Hexeth-4 Carboxylate, Hydrogenated sodium coconut fatty acid, hydrogenated sodium methyl cocoyl isethionate, partially hydrogenated palm oil Sodium tallow fatty acids, partially hydrogenated sodium tallow fatty acids, hydrogenated tallow sodium glutamate sodium, hydroxylauryldimonium ethyl phosphate sodium, sodium hydroxy Propyl carbohydrate sulfonate, sodium hydroxypropyl phosphate decyl Glucoside Cross-Linked Polymer, Sodium Hydroxypropyl Phosphate Lauryl Glucoside Crosslinked Polymer, Sodium Hydroxypropyl Sulfonate Cocoglucoside Crosslinked Polymer Sodium Hydroxypropyl Sulfonate Decyl Glucoside Crosslinked Polymer, Sodium Hydroxypropylsulfonate Laurylglucoside Crosslinked Polymer, Hydroxyste Sodium Isostearate, Sodium Isostearate, Sodium Isosteareth-6 Carboxylate Sodium, Sodium Isosteareth-11 Carboxylate, Sodium Isostearoamphoacetate , sodium isostearoamphopropionate, Sodium N-Isostearyl Methyl Taurate, Sodium Laneth Sulfate, Lanolin Fat Sodium Lauramide, Sodium Lardate, Lauramide Dioxide Sodium acetate, sodium lauraminopropionate, sodium laurate, laureth Sodium laureth-3 carboxylate, sodium laureth-4 carboxylate, laureth-5 carboxylate Sodium Laureth-6 Carboxylate, Sodium Laureth-8 Carboxylate , Sodium laureth-11 carboxylate, Sodium laureth-12 carboxylate, Laureth Sodium Laureth-13 Carboxylate, Sodium Laureth-14 Carboxylate, Laureth-16 Sodium Carboxylate, Sodium Laureth-17 Carboxylate, Sodium Laureth Sulfate , Sodium Laureth-5 Sulfate, Sodium Laureth-7 Sulfate, Sodium Laureth-8 Sulfate Um, Sodium Laureth-12 Sulfate, Sodium Laureth-40 Sulfate, Laureth-7 Sulfate Sodium tartrate, sodium lauriminodipropionate, sodium lauroamphoacetate, Sodium Lauroampho Hydroxypropyl Sulfonate, Lauroampho PG-Acetate Phosphate Sodium, Sodium Lauroamphopropionate, Sodium Lauroyl Aspartate , lauroyl collagen amino acid sodium, lauroyl glycine propionate sodium um, sodium lauroyl hydrolyzed collagen, sodium lauroyl hydrolyzed silk , Sodium Lauroyl Hydroxypropyl Sulfonate, Sodium Lauroyl Isethionate Sodium, Sodium Lauroyl Methyl Aminopropionate, Lauroyl Methyl Isethionate Sodium Phosphate, Sodium Lauroyl Myristate Amino Acids, Sodium Lauroyl / Myristate Tolyl Asparaginate, Sodium Lauroyl Oat Amino Acids, Lauroyl Sarco Sodium Lauroyl Silk Amino Acid, Sodium Lauroyl Taurate Calcium, Sodium Lauroyl Wheat Amino Acids, Sodium Lauryl Diethylenediaminoglycinate Sodium Lauryl Glucose Carboxylate, Sodium Lauryl Glucoside Hydroxypropyl phosphate, hydroxypropyl sulfonate lauryl glucoside Sodium, Sodium Lauryl Glycolcarboxylate, Lauryl Hydroxyacetic Acid Amido Sulfate Sodium, Sodium Lauryl Phosphate, Sodium Lauryl Sulfate, Lauryl Sulfoacetate Sodium, Sodium Linoleate, Sodium Macadamia Seed Oil Fatty Acids, Mango Beans Sodium fumarate, sodium mango seed oil fatty acid, sodium laureth-2 / MEA Sulfosuccinate, Sodium Methoxy PPG-2 Acetate, Methyl Cocoyl Taurate Sodium Phosphate, Sodium Methyl Lauroyl Taurate, Methyl Myristoyl Taurine Sodium oleoyl methyl taurate, Sodium palmitoyl methyl taurate Sodium, Sodium Stearoyl Methyl Taurate, Methyl-2-Sulfolaurate Sodium, Sodium Methyl-2-sulfopalmitate, Sodium Methyl Taurate Isopalmitamide, Sodium Methyl Taurine Cocoyl Methyl Taurate, Sodium Myristyl Sulfate Sodium myristate, sodium myristate, sodium myristoamphoacetate, myristoyl Sodium glutamate, sodium myristoyl hydrolyzed collagen, sodium mirin Myristoyl isethionate, sodium myristoyl sarcosinate, sodium myristyl sulfate sodium, nonoxynol-6 phosphate sodium, nonoxynol-9 phosphate sodium, Nonoxynol-1 Sodium Sulfate, Nonoxynol-3 Sodium Sulfate, Nonoxynol Sodium nonoxynol-4 sulfate, sodium nonoxynol-6 sulfate, sodium nonoxynol-8 sulfate Thorium, Nonoxynol-10 Sodium Sulfate, Nonoxynol-25 Sodium Sulfate , Octoxynol-2 sodium ethanesulfonate, Octoxynol-2 sodium sulfate Sodium Octoxynol-6 Sulfate, Sodium Octoxynol-9 Sulfate, Sodium oleate, sodium oleoamphoacetate, oleoamphohydroxypropyl Sodium Sulfonate, Sodium Oleoamphopropionate, Sodium Oleoyl Hydrolyzed Collagen, Sodium Oleoyl Isethionate, Sodium Oleth Sulfate, Natto Sodium oleyl methyl isethionate, sodium oleyl sulfate, sodium olive amphoacetate Thorium, Sodium Olive Oil Fatty Acids, Sodium Olive Oil Fatty Acid Glutamate, Sodium palm amphoacetate, sodium palm fatty acid, sodium palm glyceryl sulfonate Sodium Palmitate, Sodium Palmitoyl Hydrolyzed Collagen, Natto Sodium palmitoyl hydrolyzed wheat protein, sodium palmitoyl sarcosinate, Sodium Palm Kernel Fatty Acid, Sodium Palm Carnelolisethionate, Palm Fatty Acid Monosodium Glutamate, Passiflora Edulis Seed Oil Sodium Fatty Acids , Peanut Sodium Amphoacetate, Sodium Peanut Oil Fatty Acids, PEG-6 Cocamidopropyl Betaine Sodium Cocamide Carboxylate, PEG-8 Sodium Cocamide Carboxylate, PEG-4 Cocamide Sodium lauramide sulfate, PEG-3 sodium lauramide carboxylate, PEG-4 lauramide Sodium Carboxylate, PEG-8 Palm Glyceride Sodium Carboxylate, Sodium Pentaerythrityl hydroxypropyliminodiacetate dendrimer (Pentae rythrityl hydroxypropyl lminodiacetate D endrimer), sodium propoxylated PPG-2 acetate, rapeseed oil fatty acid sodium Sodium, Rice Bran Sodium Amphoacetate, Sodium Ricinoleate, Sodium Ricinoleate Oamphoacetate, rosehip sodium amphoacetate, sodium rosinate, safflower Sodium saffronate, sodium saffronate, hydrolyzed soy protein, sesame seeds Sodium oil fatty acids, sesame sodium amphoacetate, shea butter sodium amphoacetate, Sodium soybean oil fatty acid, sodium soybean hydrolyzed collagen, sodium stearate Sodium stearoamphoacetate, sodium stearoamphohydroxypropylsulfate Caseinate, Sodium Stearoamphopropionate, Sodium Stear...

Claims

1. (a1) an effective amount of 1,2-heptanediol; (b1) an effective amount of at least one antimicrobial component, and (c1) optionally, a small amount for a food, cosmetic or pharmaceutical composition, or a home care product; at least one active substance and / or additive, or (a2) an effective amount of 2,3-heptanediol; (b2) an effective amount of at least one antimicrobial component, and (c2) optionally, a small amount for a food, cosmetic or pharmaceutical composition, or a home care product; at least one active substance and / or additive, or (a3) A mixture containing effective amounts of 1,2-heptanediol and 2,3-heptanediol. thing, (b3) an effective amount of at least one antimicrobial component, and (c3) optionally, a small amount for a food, cosmetic or pharmaceutical composition, or a home care product; A composition comprising or consisting of at least one active substance and / or additive.

2. (a) an effective amount of at least one linear alkane having a carbon chain of 5 to 14 carbon atoms; Diol or at least one first linear alkyl group having a carbon chain of 5 to 14 carbon atoms. and a first linear alkanediol having 5 to 14 carbon atoms different from the first linear alkanediol. a mixture of one or more second linear alkanediols having a carbon chain of (b) an effective amount of at least one antimicrobial component, and (c) optionally, a small amount for a food, cosmetic or pharmaceutical composition, or home care product; A composition comprising or consisting of at least one active substance and / or additive.

3. The linear alkanediol or the first linear alkanediol is selected from the group consisting of pentanediol, hexanediol, Sandiol, heptanediol, octanediol, nonanediol, decanediol , undecanediol, dodecanediol, and tridecanediol, especially heptanediol 3. The method according to claim 2, wherein the diol is selected from the group consisting of diols, octanediol and nonanediol. The composition described.

4. The linear alkanediol or first linear alkanediol is selected from the group consisting of pentanediol, heptanediol, selected from the group consisting of hexanediols and nonanediols, in particular heptanediol; The composition according to claim 2 or claim 3.

5. The second linear alkanediol is selected from the group consisting of pentanediol, hexanediol, heptanedioic acid, and the like. ol, octanediol, nonanediol, decanediol, undecanediol, dodecanediol 5. The hydroxybenzoate of claim 2, wherein the hydroxybenzoate is selected from the group consisting of decanediol, decanediol, and tridecanediol. The composition described in any one of claims 1 to 4.

6. The linear alkanediol, the first linear alkanediol or the second linear alkanediol The diol is an (x, x+1) structural isomer (where x is the number of times the OH group of the alkanediol is chemically bonded). represents the number of carbon atoms in the alkanediol chain to which it is bonded), and in particular 1,2-alkanediol alkanediol, 2,3-alkanediol, 3,4-alkanediol, or a mixture thereof, preferably The composition according to any one of claims 2 to 5, which is preferably a 2,3-alkanediol. thing.

7. The linear alkanediol or first linear alkanediol is 1,2-pentanediol, 2,3-pentanediol, 1,2-hexanediol, 2 , 3-hexanediol, 1,2-heptanediol, 2,3-heptanediol, 1,2-octanediol, 2 , 3-octanediol, 1,2-nonanediol, 2,3-nonanediol, 1,2-decanediol, 2,3- decanediol, 1,2-undecanediol, 2,3-undecanediol, 1,2-dodecanediol , 2,3-dodecanediol, 1,2-tridecanediol, 2,3-tridecanediol, and mixtures thereof selected from the group consisting of: Preferably, the linear alkanediol or first linear alkanediol is 1,2-pentaalkanediol. 2,3-pentanediol, 1,2-hexanediol, 2,3-hexane Diol, 1,2-heptanediol, 2,3-heptanediol, 2,3-octanediol 2,3-nonanediol, 2,3-nonanediol, and mixtures thereof; and / or The second linear alkanediol is 1,2-pentanediol, 2,3-pentanediol, 1,2-hexanediol, 2 , 3-hexanediol, 1,2-heptanediol, 2,3-heptanediol, 1,2-octanediol, 2 , 3-octanediol, 1,2-nonanediol, 2,3-nonanediol, 1,2-decanediol, 2,3- decanediol, 1,2-undecanediol, 2,3-undecanediol, 1,2-dodecanediol , 2,3-dodecanediol, 1,2-tridecanediol, 2,3-tridecanediol, and mixtures thereof selected from the group consisting of: Preferably, the second linear alkanediol is 1,2-pentanediol, 2,3-pentanediol, Hexanediol, 1,2-hexanediol, 2,3-hexanediol, 1,2-heptane Diol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol 7. The method according to claim 2, wherein the hydroxybenzoate is selected from the group consisting of hydroxybenzoates and mixtures thereof. The composition described.

8. At least one first linear alkanediol and one or more second linear alkanediols. The mixture containing glycanediol is a mixture comprising 1,2-pentanediol and 2,3-pentanediol; a mixture comprising 1,2-hexanediol and 2,3-hexanediol; a mixture comprising 1,2-heptanediol and 2,3-heptanediol; a mixture comprising 1,2-octanediol and 2,3-octanediol; a mixture comprising 1,2-nonanediol and 2,3-nonanediol; a mixture comprising 1,2-decanediol and 2,3-decanediol; a mixture comprising 1,2-undecanediol and 2,3-undecanediol; A mixture comprising 1,2-dodecanediol and 2,3-dodecanediol, and The group consisting of mixtures containing 1,2-tridecanediol and 2,3-tridecanediol The composition of claim 7, wherein the composition is selected from:

9. At least one first linear alkanediol and one or more second linear alkanediols. The mixture containing candiol is a mixture comprising 1,2-hexanediol and 2,3-octanediol; a mixture comprising 1,2-octanediol and 2,3-hexanediol, and From the group consisting of mixtures containing 1,2-octanediol and 2,3-heptanediol The composition of claim 7 .

10. At least one first linear alkanediol and one or more second linear alkanediols. The mixture containing candiol is a mixture comprising 1,2-pentanediol and 2,3-hexanediol; a mixture comprising 1,2-pentanediol and 1,2-heptanediol; a mixture comprising 1,2-pentanediol and 2,3-heptanediol; a mixture comprising 1,2-pentanediol and 2,3-octanediol; a mixture comprising 1,2-pentanediol and 1,2-nonanediol, and A mixture containing 1,2-pentanediol and 2,3-nonanediol is selected from the group consisting of The composition of claim 7 .

11. At least one first linear alkanediol and one or more second linear alkanediols. The mixture containing glycanediol is a mixture comprising 1,2-heptanediol and 1,2-octanediol; a mixture comprising 1,2-heptanediol and 2,3-octanediol; a mixture comprising 1,2-heptanediol and 1,2-nonanediol, and A mixture containing 1,2-heptanediol and 2,3-nonanediol is selected from the group consisting of The composition of claim 7 .

12. The linear alkanediol is 2,3-pentanediol, 2,3-hexanediol, 2 ,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3 -decanediol, 2,3-undecanediol, 2,3-dodecanediol, 2,3- tridecanediols and mixtures thereof, preferably linear alkyl The hexanediols are 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, Tandiol, 2,3-octanediol, 2,3-nonanediol and mixtures thereof The cosmetic or pharmaceutical composition or hoWever according to claim 7, Which is selected from the group consisting of Mucare products.

13. A linear alkanediol, or a first linear alkanediol, or a second alkanediol The ol has a maximum water solubility of 10% by weight or less, in particular a maximum water solubility of 5% by weight or less and 1.4% by weight or more. Alkanediols with high water solubility, preferably 1,2-heptanediol, 2,3- Heptanediol, 2,3-octanediol, and mixtures thereof.

13. The composition of claim 2, wherein the alkanediol is selected from the group consisting of alkanediols.

14. - A mixture containing 1,2-heptanediol and 2,3-heptanediol is 2-heptanediol and 2,3-heptanediol in a ratio of 50:50 to 99.9:0 1, preferably in a ratio ranging from 75:25 to 99:1, and more preferably in a ratio ranging from 80:20 to A ratio ranging from 90:10 to 95:5 is more preferred. more preferably; or at least one first linear alkanediol and one or more second linear The mixture comprising an alkanediol comprises a first linear alkanediol and a second linear alkanediol. ol in a ratio ranging from 50:50 to 99.9:0.1, preferably from 75:25 to 99 :1, with a ratio ranging from 80:20 to 98:2 being more preferred, or 14. Any one of claims 1 to 13, wherein a ratio in the range of 10 to 95:5 is even more preferred.

1. A cosmetic or pharmaceutical composition or home care product according to claim 1.

15. At least one antimicrobial component is caprylhydroxamic acid, o-cymen-5-ol alcohol, isopropylparaben, capryloyl glycine, phenylpropanol, tropol , Cocoyl Arginate Ethyl PCA, 2-Methyl 5-Cyclohexyl Pentanol, Phenoxyethanol, disodium EDTA, methylparaben and its salts, sodium benzoate Sodium, benzyl alcohol, potassium sorbate, benzyl salicylate, propyl palmitate Raben, sodium methylparaben, methylchloroisothiazolinone, methylisothiazolinone Linone, ethylhexylglycerin, butylparaben, ethylparaben, propylparaben sodium, DMDM ​​hydantoin, dehydroacetic acid, salicylic acid, chlorphenesin, Isobutylparaben, ethylparaben sodium, diazolidinyl urea, diazolidinyl Urea, Farnesol, Bisabolol, Glyceryl Caprylate, Sodium Phytate or phytic acid, sodium levulinate or levulinic acid and its esters and / or or ketal, chlorhexidine, glyceryl laurate, anisic acid and its salts, jigu Chlorhexidine disodium EDTA, salicylate, phenethyl alcohol, capric acid glycerin Seryl, Sorbitan Caprylate, Tetrasodium Glutamate Diacetate, Ethylenediamine Di Trisodium succinate, hydroxyethoxyphenyl butanone, hydroxyethoxyphenyl Nylbutanol, Itaconic Acid, Octopirox, Propanediol Caprylate, Chlorpheniramine Imbazole, undecylenoylglycine, thymol, 4-hydroxyacetophenone, milk Acid, sodium lactate, 1,3-propanediol, 1,2-pentanediol, 1,2- Hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-octanediol Nanediol, 1,2-decanediol, 2,3-pentanediol, 2,3-hexane Diol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol and mixtures of two or more of the foregoing antimicrobial components; 15. The composition of any one of claims 1 to 14.

16. 1,2-heptanediol and 1,2-octanediol, or 1,2-heptanediol and 2,3-heptanediol, or 1,2-pentanediol and 2,3-pentanediol, or 1,2-hexanediol and 2,3-hexanediol, or 1,2-heptanediol and 2,3-heptanediol, or 1,2-octanediol and 2,3-octanediol, or 1,2-nonanediol and 2,3-nonanediol, or 1,2-decanediol and 2,3-decanediol, or 1,2-undecanediol and 2,3-undecanediol, or comprising or consisting of 1,2-dodecanediol and 2,3-dodecanediol; 16. The composition of any one of claims 1 to 15.

17. At least one food, cosmetic, or pharmaceutical composition, or home care product The active substances and / or additives may act as agents against skin aging, antioxidants, Fats, emulsifiers, surfactants, green and synthetic polymers, skin cooling agents, rheological additives additives, oils, fragrances or perfume oils, polyols, and two or more of the above-mentioned substances.

17. The composition of any one of claims 1 to 16, selected from the group consisting of the above mixtures. 。

18. and further comprising at least one antimicrobial agent (b) different from the antimicrobial component, The agent is 2-benzylheptanol, alkyl (C12-22) trimethylammonium Bromide and chloride, ascorbic acid and its salts, benzalkonium bromide, benzalkonium chloride Benzalkonium, Benzalkonium saccharinate, Benzethonium chloride, Benzoic acid, Can Fur, cetylpyridinium chloride, chlorhexidine diacetate, chlorhexidine dihydrochloride, Chlorocresol, chloroxylenol, cyclohexylglycerin, dimethylphenyl Butanol, dimethylphenylpropanol, ethanol, ethyl lauroyl arginine HCl, Ethyl Lauroyl Arginate Laurate, Eucalyptol, Gluconic Acid and and its salts, glycerin, hexamidine, hexamidine diisethionate, hexylglycerin Phosphorus, butylcarbamate iodide propynyl, Jasmol, lauryl alcohol, levulinic acid acid and its esters and / or ketals, mannitol, menthol, salicylic acid Methyl acetate, Octenidine HCl, Polyarginine, Polyglyceryl-10 laurate, Polyglyceryl-2 Caprylate, Polyglyceryl-3 Caprylate, Polylysine, Salvi Sage (Sage) Oil, Silver Chloride, Silver Citrate, Caproyl Lactylate Sodium Caproyl / Lauroyl Lactylate, Sodium Lauroyl Lactylate Sodium sorbate, sorbitol, tetraselmis extract, triclocarban, Triclosan, triethyl citrate, xylityl sesquicaprylate, zinc citrate, pyri consisting of zinc thionate, zinc ricinoleate, and mixtures of two or more of the aforementioned antimicrobial agents 18. The composition of any one of claims 1 to 17, selected from the group:

19. 1,2-heptanediol or 2,3-heptanediol, or 1,2-heptanediol a mixture comprising at least one linear benzoate and 2,3-heptanediol; an alkanediol, or at least one first linear alkanediol, and one or more or a mixture containing a plurality of second linear alkanediols, 0.001 to 15g of the total weight of a food or pharmaceutical preparation or home care product 0.0% by weight, with 0.01 to 10.0% by weight being preferred, and 0.1 to 5.0% by weight being preferred. Amounts of 0.3 to 3.0% by weight are more preferred, and amounts of 0.5 to 3.0% by weight are even more preferred.

19. The composition according to any one of claims 1 to 18, wherein an amount of from 1.0 to 1.0% by weight is more particularly preferred. Finished product.

20. 1,2-heptanediol and 2,3-heptanediol in a composition, or 0.0 by total weight of finished food, cosmetic or pharmaceutical preparations, or home care products In an amount of 0.01 to 15.0% by weight, in particular in an amount of 0.01 to 10.0% by weight, more in particular 0. Preferably, the amount is from 1 to 5.0 wt. %, with 0.3 to 3.0 wt. % being even more preferred, and 0 Amounts of 0.5 to 1.0% by weight are even more particularly preferred; The total weight of the composition or the finished food, cosmetic or pharmaceutical preparation, or home care product Preferably in an amount of 0.001 to 0.5% by weight, more preferably in an amount of 0.005 to 0.5% by weight, based on the total weight of the compound. in an amount of from 0.01 to 0.075 wt. %; Iwa as a linear alkanediol or as at least one first linear alkanediol and one or more second linear alkanediols. The candiol may be added to the composition or to the finished food, cosmetic or pharmaceutical preparation, or to the home In an amount of from 0.001 to 15.0% by weight, in particular from 0.01 to 1.0% by weight, based on the total weight of the care product. 0.0 wt. %, more particularly 0.1 to 5.0 wt. %, and preferably 0.3 to 3.0 wt. %. Even more preferred is an amount of 0.5 to 1.0 wt. %; The total weight of the composition or the finished food, cosmetic or pharmaceutical preparation, or home care product Preferably in an amount of 0.001 to 0.5% by weight, more preferably in an amount of 0.005 to 0.5% by weight, based on the total weight of the compound. % by weight and most preferably in an amount of 0.01 to 0.075% by weight, 2,3-heptanediol or a mixture thereof, 19. A cosmetic or pharmaceutical composition, or a home care product, according to any one of claims 19 to 18.

21. At least one antimicrobial component is present in an amount of from 0.01 to 25.0% by weight of the total composition. 0% by weight, in particular in an amount of 0.02 to 15.0% by weight, more in particular in an amount of 0.05 to 6.0% by weight.

21. The composition of any one of claims 1 to 20, comprising 0% by weight of

22. A food, cosmetic or pharmaceutical preparation comprising a composition according to any one of claims 1 to 21. Manufactured goods.

23. i. In the form of a dispersion containing an oil component in an amount of ≧1 wt. %, in particular in an amount of ≧3 wt. %, , preferably emulsions, in particular O / W emulsions, W / O emulsions, multiple emulsions Solution, water-dispersed gel, balm, water-in-oil type (W / O / W) or oil-in-water type (O / W / O) emulsions, PIT emulsions, Pickering emulsions, My emulsions Chloremulsion, liquid, lotion, suspension, emulsion, ointment, paste, gel, cream in the form of a liquid, oil-based or liposomal formulation; ii. In the form of a liquid surfactant formulation; iii. In the form of a solid surfactant formulation; iv. Aqueous or aqueous / alcoholic, especially aqueous / ethanolic solutions, or aqueous / glycolic solutions. in the form of a cholesteric solution; in particular, when the cosmetic or pharmaceutical preparation is a cryogenic preparation, 23. A cosmetic or pharmaceutical preparation according to claim 22.

24. Inhibit or inhibit the growth of microorganisms in food, cosmetics or pharmaceuticals, or home care products 22. Use of a composition according to any one of claims 1 to 21 for inhibiting

25. The microorganism is a species of the genus Pseudomonas, Staphylococcus aphylococcus, Escherichia, Candida Candida, Aspergillus and their groups and combinations thereof, particularly Pseudomonas aeruginosa aeruginosa), Staphylococcus aureus (Staphyloc occus aureus, Escherichia coli ), Candida albicans and Aspergillus Aspergillus brasiliensis, and combinations, more particularly Candida albicans and and Aspergillus brasiliensis 25. The use according to claim 24, wherein the compound is selected from the group consisting of:

26. Enhancement of the efficacy of antimicrobial components, preferably antimicrobial components according to claim 15 1,2-heptanediol or 2-heptanediol according to any one of claims 2 to 14 ,3-heptanediol, or 1,2-heptanediol and 2,3-heptanediol or at least one linear alkanediol, or at least one one first linear alkanediol and one or more second linear alkanediols Use of a mixture containing

27. Inhibit or inhibit the growth of microorganisms in food, cosmetics or pharmaceuticals, or home care products is a method for inhibiting: - preparing a food, cosmetic or pharmaceutical preparation, or a home care product; - a step incorporating an effective amount of an antimicrobial composition according to any one of claims 1 to 15 A method, including

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