Radiographic image analyzing method, radiographic image capturing method, radiographic image analyzing apparatus, radiographic image capturing apparatus, and radiographic image system

Abstract

To provide a radiation image photographing program, a radiation image analyzing method, a radiation image photographing method, a radiation image analyzing apparatus, a radiation image photographing apparatus, and a radiation image system capable of performing a plurality of dynamic analyses in combination for a subject.SOLUTION: A radiographic image analysis program according to the present disclosure causes a computer to execute a step of acquiring a plurality of frame images generated by performing dynamic imaging by irradiating a subject with radiation under imaging conditions corresponding to a combination of a plurality of types of preset dynamic analysis, and a step of performing the plurality of types of dynamic analysis included in the combination based on the plurality of frame images.SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] The present disclosure relates to a radiographic image analysis program, a radiographic image capturing program, a radiographic image analysis method, a radiographic image capturing method, a radiographic image analysis device, a radiographic image capturing device, and a radiographic image system. [Background technology]

[0002] Conventionally, still image capture technology, which uses films, screens, photostimulable phosphor plates, etc. to create images of radiation that has passed through the area to be examined in a subject, and radiological diagnostic technology using this technology have been widely used. On the other hand, dynamic radiological imaging technology has been developed in recent years, in which radiation is continuously irradiated onto the area to be examined, and the transmitted radiation is captured multiple times per unit time using a semiconductor image sensor such as an FPD (Flat Panel Detector), to generate moving images of the area to be examined.

[0003] Patent document 1 discloses a dynamic analysis system that extracts lung field areas from dynamic chest images, calculates features related to the extracted lung field areas, and selects effective sections for dynamic analysis from a series of frame images of the dynamic image based on the calculated features. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Laid-Open No. 2017-205187 Summary of the Invention [Problem to be solved by the invention]

[0005] There are various types of dynamic image analysis (dynamic analysis) depending on the area being analyzed. For example, dynamic analysis of the chest includes extraction of lung field areas, tracking of diaphragm displacement, extraction of tracheal walls, visualization of lung tissue behavior with breathing, and visualization of blood flow within the lung field synchronized with the heartbeat.

[0006] It has been proven that combining multiple types of dynamic analysis in dynamic imaging is effective for diagnosing specific diseases. For example, in diagnosing COPD (chronic obstructive pulmonary disease), extraction of lung field areas, extraction of tracheal walls, and visualization of lung tissue behavior during breathing are useful.

[0007] Dynamic imaging, which captures the dynamic images required for dynamic analysis, must be performed under imaging conditions suited to the type of dynamic analysis required. This is because the physical condition of the subject during dynamic imaging and the frame image parameters required for dynamic analysis (frame rate, dose, etc.) may differ depending on the type of dynamic analysis.

[0008] The present disclosure aims to provide a radiographic image capturing program, a radiographic image analysis method, a radiographic image capturing method, a radiographic image analysis device, a radiographic image capturing device, and a radiographic image system that can perform a combination of multiple dynamic analyses on a subject. [Means for solving the problem]

[0009] A radiological image analysis program according to one aspect of the present disclosure causes a computer to perform the following steps: acquiring multiple frame images generated by performing dynamic imaging by irradiating a subject with radiation under imaging conditions corresponding to a combination of multiple types of dynamic analyses that have been set in advance; and performing the multiple types of dynamic analyses included in the combination based on the multiple frame images.

[0010] A radiographic imaging program according to one aspect of the present disclosure causes a computer to execute the following steps: acquiring setting information regarding a combination of multiple types of dynamic analysis; determining dynamic imaging conditions based on the setting information; and performing dynamic imaging of the subject by irradiating the subject with radiation based on the determined imaging conditions, thereby generating multiple frame images.

[0011] In a radiological image analysis method according to one aspect of the present disclosure, a computer included in a radiological image analysis device acquires multiple frame images generated by performing dynamic imaging by irradiating a subject with radiation under imaging conditions corresponding to a combination of multiple types of dynamic analyses that have been set in advance, and performs the multiple types of dynamic analyses included in the combination based on the multiple frame images.

[0012] In a radiographic image capturing method according to one aspect of the present disclosure, a computer included in a radiographic image capturing device acquires setting information regarding a combination of multiple types of dynamic analysis using the radiographic image, determines, based on the setting information, the imaging conditions for irradiating a subject with radiation to perform dynamic imaging, performs the dynamic imaging of the subject based on the determined imaging conditions, and generates multiple frame images.

[0013] A radiological image analysis device according to one aspect of the present disclosure includes an image acquisition unit that acquires a plurality of frame images generated by performing dynamic imaging by irradiating a subject with radiation under imaging conditions corresponding to a combination of a plurality of types of dynamic analyses that have been set in advance, and an analysis unit that performs the plurality of types of dynamic analyses included in the combination based on the plurality of frame images.

[0014] A radiological imaging device according to one aspect of the present disclosure includes a setting information acquisition unit that acquires setting information regarding a combination of multiple types of dynamic analysis, an imaging condition determination unit that determines imaging conditions for dynamic imaging based on the setting information, and an image generation unit that performs the dynamic imaging of the subject by irradiating the subject with radiation based on the determined imaging conditions, and generates multiple frame images.

[0015] A radiological image processing system according to one aspect of the present disclosure includes the radiological image analysis device and the radiological image capturing device. [Effects of the Invention]

[0016] According to the present disclosure, a combination of multiple kinetic analyses can be performed on a subject. [Brief explanation of the drawings]

[0017] [Figure 1] A connection diagram showing a system configuration according to an embodiment of the present disclosure. [Figure 2] A block diagram illustrating the functional configuration of an imaging control device. [Figure 3] FIG. 1 is a diagram showing an example of the configuration of a radiation imaging control device; [Figure 4] FIG. 1 shows an example of the configuration of a radiological image analysis device. [Figure 5] Flowchart showing an example of operation of the radiation image processing system [Figure 6] A diagram showing the relationship between various chest diseases and dynamic analysis that is effective for diagnosing those diseases. [Figure 7] A conceptual diagram showing the relationship between elapsed time and breathing depth when dynamic imaging is performed continuously in three breathing states: quiet breathing, breath-holding, and deep breathing. DETAILED DESCRIPTION OF THE INVENTION

[0018] <Summary> The present disclosure relates to a radiographic image processing system including a radiographic image capturing device, a radiographic image capturing control device, and a radiographic image analyzing device.

[0019] The radiation image processing system of the present disclosure uses a radiation image capturing device to capture radiation image data of a subject to generate a dynamic image, and a radiation image analyzing device performs various analytical processes (dynamic analyses) using the radiation image data. The radiation imaging control device controls the imaging process (dynamic imaging) in the radiation image capturing device.

[0020] In this specification, dynamic radiography refers to obtaining multiple images showing the dynamics of a subject by repeatedly irradiating the subject with pulsed radiation such as X-rays at predetermined intervals (pulse irradiation) or by continuously irradiating the subject with radiation at a low dose rate without interruption (continuous irradiation). In this specification, a series of images obtained by dynamic radiography is referred to as a dynamic image, and each of the multiple images that make up a dynamic image is referred to as a frame image. In addition, in this specification, various analytical processes performed using dynamic images are referred to as dynamic analysis.

[0021] In the radiation image processing system of the present disclosure, a combination of multiple types of dynamic analyses to be performed on a subject is set before dynamic imaging. The combination of multiple types of dynamic analyses may be determined, for example, by a doctor who examines the subject based on a disease that the subject is predicted to suffer from.

[0022] In the radiographic imaging apparatus, dynamic images are generated (that is, dynamic imaging) based on imaging conditions that are set according to a combination of multiple types of dynamic analyses performed on the subject.

[0023] By performing such operations, the radiation image processing system of the present disclosure can generate radiation image data necessary for combining multiple types of dynamic analyses useful for a specific disease in a single imaging process, minimizing the burden on the subject. This makes it possible to perform dynamic analyses that are optimal for the subject and highly accurate, while minimizing the burden on the subject and the user of the radiation image processing system (such as a doctor or radiographer).

[0024] Hereinafter, embodiments of the present disclosure will be described in detail with reference to the drawings.

[0025] <System configuration> 1 is a connection diagram showing a system configuration according to an embodiment of the present disclosure. A radiation image processing system 100 according to the embodiment of the present disclosure includes a radiation image capturing device 10, a radiation image capturing control device (console device) 20, a radiation image analysis device 30, an image management device 40, and a client terminal 50.

[0026] 1, the radiographic imaging device 10 is placed in an imaging room, and the radiographic imaging control device 20 is placed in an operation room. The radiographic imaging device 10, the radiographic imaging control device 20, the radiographic image analysis device 30, the image management device 40, and the client terminal 50 are connected to each other via a communication network that complies with, for example, the DICOM (Digital Image and Communications in Medicine) standard.

[0027] The radiographic imaging device 10 performs dynamic imaging under the control of the radiographic imaging control device 20. The dynamic images generated by the radiographic imaging device 10 are transmitted to the radiographic image analysis device 30 via the radiographic imaging control device 20. The radiographic image analysis device 30 performs dynamic analysis based on the dynamic images. The dynamic images and the results of the dynamic analysis are transmitted to the client terminal 50 and viewed by medical professionals such as doctors. The dynamic images and the results of the dynamic analysis are transmitted to an image management device 40 (e.g., a PACS (Picture Archiving and Communication System)) and managed there.

[0028] The radiographic imaging device 10, the radiographic imaging control device 20, and the radiographic image analysis device 30 are each a type of computer. A computer has a processor and memory, and can implement predetermined functions by reading, expanding, and executing programs stored in the memory.

[0029] [Radiation imaging device 10] As shown in FIG. 1, the radiographic imaging device 10 includes an imaging control device 11, a radiation irradiation device 12, an imaging table 13, a radiation detection unit 14, a display device 15, and an audio device 16.

[0030] The imaging control device 11 acquires setting information related to the settings of dynamic radiography from the radiography control device 20, sets imaging conditions for performing dynamic radiography based on the setting information, and controls the radiation irradiator 12 based on the imaging conditions to irradiate the subject with radiation and perform imaging. The imaging control device 11 is composed of a CPU (Central Processing Unit), RAM (Random Access Memory), etc.

[0031] The setting information is information relating to settings for performing dynamic imaging of a subject, and is information relating to a combination of multiple types of dynamic analysis performed on the subject by the radiation image analysis device 30. The setting information is set by an operator of the radiation image processing system 100, such as a radiographer, in the radiation imaging control device 20, which will be described later.

[0032] The imaging conditions include various conditions such as the pulse rate, pulse width, pulse interval, number of frames captured per imaging, radiation dose per unit time, and the physical condition of the subject (such as respiratory state). The pulse rate is the number of radiation exposures per second and corresponds to the frame rate of the image data. The pulse width is the radiation exposure time per radiation exposure. The pulse interval is the time from the start of one radiation exposure to the start of the next radiation exposure and corresponds to the time interval (frame interval) between multiple image data. The imaging conditions may be automatically determined by the imaging control device 11 of the radiographic imaging device 10 based on the setting information.

[0033] The radiation irradiator 12 is disposed at a position facing the radiation detector 14 fixed to the imaging table 13. The radiation irradiator 12 irradiates radiation (X-rays) under the control of the imaging control device 11.

[0034] The radiation detection unit 14 is composed of a semiconductor image sensor such as an FPD (Flat Panel Detector). The radiation detection unit 14 has a substrate on which a plurality of detection elements (pixels) are arranged in a matrix, which detect radiation irradiated from the radiation irradiator 12 according to its intensity, convert the detected radiation into an electrical signal, and store the signal. Each pixel on the substrate is equipped with a switching unit such as a TFT (Thin Film Transistor).

[0035] The radiation detection unit 14 controls the switching unit of each pixel based on the image reading conditions input from the radiation imaging control device 20 to read the electrical signals accumulated in each pixel and output intensity information for each pixel to the image generation unit 113. The image reading conditions include, for example, the frame rate, frame interval, pixel size, image size (matrix size), etc. The frame rate is the number of frame images acquired per second and coincides with the pulse rate. The frame interval is the time from the start of one image data acquisition operation to the start of the next frame image acquisition operation and coincides with the pulse interval.

[0036] The radiography control device 11 and the radiation detection unit 14 are connected to each other and exchange synchronization signals with each other to synchronize the radiation irradiation operation and the image reading operation.

[0037] In this way, the radiographic imaging device 10 performs dynamic radiographic imaging by controlling the imaging control device 11 so that the radiation irradiation device 12 irradiates radiation and the radiation detection unit 14 generates image data based on the intensity of the irradiated radiation.

[0038] The display device 15 and the audio device 16 instruct the subject M on the posture and physical condition (such as respiratory state) to be taken when performing dynamic imaging of the subject M. The display device 15 is a display device such as a CRT (Cathode Ray Tube), a liquid crystal display (Liquid Crystal Display), or an organic EL (Electro Luminescence) display. The audio device 16 is an audio output device such as a speaker. The display device 15 and the audio device 16 may each give the same instructions to the subject, or only one of them may give instructions.

[0039] 2 is a block diagram illustrating the functional configuration of the imaging control device 11. The imaging control device 11 includes a setting information acquisition unit 111, an imaging condition determination unit 112, an image generation unit 113, and a storage unit 114.

[0040] The setting information acquisition unit 111 acquires setting information from the radiation imaging control device 20 .

[0041] The imaging condition determination unit 112 determines imaging conditions for performing dynamic imaging of a subject based on the setting information. Information indicating the correspondence between a combination of multiple types of dynamic analyses indicated by the setting information and imaging conditions suitable for that combination is stored in advance in the storage unit 114. The imaging condition determination unit 112 may read the information indicating the correspondence from the storage unit 114 and compare it with the setting information to determine the imaging conditions.

[0042] The image generation unit 113 performs dynamic imaging of the subject based on the determined imaging conditions and generates multiple frames of radiographic images. Specifically, the image generation unit 113 controls the operations of the radiation irradiator 12 and the radiation detection unit 14 based on the imaging conditions, and generates image data by obtaining intensity information on the intensity of radiation that has passed through the subject from the radiation detection unit 14 for each pixel.

[0043] As described above, the storage unit 114 stores in advance information indicating the correspondence between combinations of multiple types of dynamic analyses and imaging conditions suitable for those combinations.

[0044] The operations of the setting information acquisition unit 111, the photographing condition determination unit 112, and the image generation unit 113 included in the photographing control device 11 will be described in detail later.

[0045] [Radiation imaging control device 20] The radiography control device 20 is a computer such as a PC (Personal Computer), a workstation, etc. The radiography control device 20 may be a desktop computer as shown in the example of Fig. 1, or may be a portable computer, such as a notebook computer or a tablet computer.

[0046] The radiography control device 20 receives radiography order information from a RIS (Radiology Information System) or the like and transmits it to the radiography device 10, thereby controlling dynamic radiography by the radiography device 10. The radiography order information includes various information related to the next dynamic radiography to be performed, such as patient information, examination information, type of analysis, and data attributes (e.g., information indicating the body part and position, information regarding a combination of multiple types of dynamic radiography, etc.). The examination information includes an examination ID and the examination target body part (e.g., the chest, particularly the lungs or heart, etc.). The type of analysis includes, for example, ventilation analysis, pulmonary blood flow analysis, and maximum ventilation volume measurement. The data attributes include, for example, emergency, general outpatient, and ward follow-up. The radiography order information is generated, for example, when a doctor or the like requests the radiography image processing system 100 to perform dynamic radiography of a subject.

[0047] Furthermore, the radiography control device 20 generates setting information indicating at least any combination of a plurality of types of dynamic analysis that can be performed by the radiographic image analyzer 30, based on radiography order information or input by the operator.

[0048] When the radiography control device 20 generates setting information based on the radiography order information, the following procedure can be considered. Combinations of many types of dynamic analysis are defined as presets on the RIS in advance. In this case, for example, a doctor selects a preset combination on the RIS depending on the type of dynamic analysis image he or she wishes to obtain. Radiography order information including information about the combination selected by the doctor is generated by the RIS, and the generated radiography order information is received by the radiography control device 20. Based on the radiography order information, the radiography control device 20 generates setting information including information indicating the combination of the types of dynamic radiography to be performed, and transmits it to the radiography control device 11. This allows the radiography control device 20 to control the dynamic radiography of the radiographic image capturing device 10.

[0049] When the radiation imaging control device 20 generates setting information based on imaging order information, the radiation imaging device 10 may have information in advance regarding what types of dynamic imaging combinations can be instructed by the setting information.

[0050] When the radiation imaging control device 20 generates setting information based on input from the operator, the following procedure can be considered. The operator obtains information regarding the type of dynamic imaging requested by the doctor from the doctor who sent the imaging order information on the RIS by a separate means (e.g., email, telephone, chat, checking the electronic medical record, etc.). The operator determines what combination should be performed based on the obtained information, and generates setting information including information indicating the type of dynamic imaging combination to be performed in the radiation imaging control device 20. In this case, the radiation imaging control device 20 and the radiation image capturing device 10 may previously have information regarding what types of dynamic imaging combinations can be set in the setting information. Alternatively, instead of the operator determining what combination should be performed, the radiation imaging control device 20 may determine what type of dynamic imaging combination should be performed based on various information input by the operator.

[0051] 3 is a diagram showing an example of the configuration of the radiation imaging control device 20. The radiation imaging control device 20 has a control unit 21, a storage unit 22, an operation unit 23, a display unit 24, and a communication unit 25. The components of the radiation imaging control device 20 are connected to each other via a bus 26.

[0052] The radiation imaging control device 20 outputs setting conditions set by an operator or the like and imaging order information acquired in advance from a RIS or the like to the radiation imaging device 10, and controls the imaging process by the radiation imaging device 10. The radiation imaging control device 20 may also display dynamic images generated by the radiation imaging device 10 so that the operator can check them, for example.

[0053] The control unit 21 is configured with a CPU, RAM, etc. In the control unit 21, the CPU reads out the system program and various processing programs stored in the storage unit 22 in response to an operation of the operation unit 23, loads them into the RAM, and controls the operation of each unit of the radiation imaging control device 20 based on the loaded programs.

[0054] The storage unit 22 is configured with a non-volatile semiconductor memory, a hard disk, etc. The storage unit 22 stores various programs executed by the control unit 21, parameters required for executing processes by the programs, data such as processing results, etc. The various programs are stored in the form of readable program code, and the control unit 21 sequentially executes operations in accordance with the program code.

[0055] The storage unit 22 also stores image reading conditions for dynamic imaging. Furthermore, the storage unit 22 stores imaging order information transmitted from the RIS, etc. When the radiation imaging control device 20 controls dynamic imaging of the radiation image capturing device 10, it reads out the image reading conditions and imaging order information corresponding to the subject from the storage unit 22 and transmits them.

[0056] The operation unit 23 is an operation device such as a keyboard equipped with cursor keys, numeric input keys, and various function keys, a pointing device such as a mouse or a trackball, and a touch panel. The operation unit 23 generates an instruction signal based on an input from the operator and outputs it to the control unit 21.

[0057] The display unit 24 is configured with a display device such as a CRT, a liquid crystal display, an organic EL display, etc. In accordance with instructions of a display signal input from the control unit 21, the display unit 24 displays input instructions from the operation unit 23, image data generated by the radiographic imaging device 10, etc.

[0058] The communication unit 25 transmits and receives data to and from the radiation image capturing device 10, the radiation image analyzing device 30, the RIS, and the like.

[0059] [Radiation image analyzer 30] The radiation image analysis device 30 is a computer such as a PC, a workstation, etc. The radiation image analysis device 30 may be a desktop computer or a portable computer, such as a laptop computer or a tablet computer.

[0060] The radiographic image analysis device 30 performs multiple types of dynamic analyses based on the dynamic images captured by the radiographic image capturing device 10, based on the setting information (information regarding the combination of multiple types of dynamic analyses) set in the radiographic image capturing control device 20.

[0061] 4 is a diagram showing an example of the configuration of the radiographic image analysis device 30. The radiographic image analysis device 30 has a control unit 31, a storage unit 32, an operation unit 33, a display unit 34, and a communication unit 35. The components of the radiographic image analysis device 30 are connected by a bus 36.

[0062] The control unit 31 is configured with a CPU, RAM, etc. In the control unit 31, the CPU reads out the system program and various processing programs stored in the storage unit 32 in response to the operation of the operation unit 33, and loads them into the RAM, and performs operation control of each unit of the radiological image analyzer 30, dynamic analysis, etc. based on the loaded programs.

[0063] The control unit 31 has an image acquisition unit 311 and an analysis unit 312. The image acquisition unit 311 acquires multiple frames of radiographic images generated by the radiographic image capturing device 10. The analysis unit 312 executes multiple types of dynamic analysis included in the combination based on the multiple frames of radiographic image data.

[0064] The operations of the image acquisition unit 311 and the analysis unit 312 included in the control unit 31 will be described in detail later.

[0065] The storage unit 32 is configured with a non-volatile semiconductor memory, a hard disk, etc. The storage unit 32 stores various programs executed by the control unit 31, parameters required for executing processes by the programs, data such as processing results, etc. The various programs are stored in the form of readable program code, and the control unit 31 sequentially executes operations in accordance with the program code.

[0066] The storage unit 32 also stores list information indicating patient information, examination information, and status (e.g., progress status such as receiving, dynamic analysis in progress, analysis completed, etc.) related to each dynamic image that is generated by the radiographic imaging device 10. The storage unit 32 also stores analysis results in association with the dynamic images.

[0067] The operation unit 33 is an operation device such as a keyboard equipped with cursor keys, numeric input keys, and various function keys, a pointing device such as a mouse or a trackball, and a touch panel. The operation unit 33 generates instruction signals based on input by the operator and outputs them to the control unit 31. The operation unit 33 may also be equipped with a touch panel on the display screen of the display unit 34, in which case the operation unit 33 outputs instruction signals input via the touch panel to the control unit 31.

[0068] The display unit 34 is configured with a display device such as a CRT, a liquid crystal display, an organic EL display, etc. In accordance with instructions of a display signal input from the control unit 31, the display unit 34 displays input instructions from the operation unit 33, image data generated by the radiographic imaging device 10, etc.

[0069] The communication unit 35 transmits and receives data between the radiographic image capturing device 10 and the radiographic image analyzing device 30, etc.

[0070] <Example of overall system operation> Next, a description will be given of an example of the overall operation of the radiation image processing system 100. Fig. 5 is a flowchart showing an example of the operation of the radiation image processing system 100.

[0071] In step S1, the radiography control device 20 sets a combination of multiple dynamic analyses to be performed from multiple types of dynamic analyses using dynamic images.

[0072] For example, suppose a doctor examines a subject (patient) and predicts from the patient's symptoms that the subject is suffering from a particular disease. It is known that the radiation image processing system 100 can perform an analysis that is effective for the particular disease by combining and executing several of the multiple types of dynamic analyses that can be performed.

[0073] Alternatively, for example, in the case of a subject who has been transported to the hospital by ambulance, it may be impossible to predict the disease in advance. In this case, the radiation image processing system 100 may predetermine a combination of dynamic analyses useful for diagnosing the subject from among multiple types of dynamic analyses that can be performed.

[0074] Examples of types of dynamic analysis when the subject's chest (lungs) is the imaging target include chest bone attenuation processing, frequency emphasis processing, diaphragm movement tracking processing, lung field movement visualization processing, lung field area measurement processing, tracheal diameter measurement processing, ventilation analysis processing, blood flow analysis processing, and second blood flow analysis processing.

[0075] Chest bone attenuation processing is processing that attenuates signals from ribs or clavicles in the lung field, making it possible to generate lung field images in which bones are not displayed overlapping each other.

[0076] Frequency emphasis processing is a process that emphasizes the movement of intrapulmonary tissue with a specific frequency, and by using frequency emphasis processing, it is possible to improve visibility by highlighting the edges of the tissue.

[0077] The diaphragm movement tracking process is a process for tracking the up and down movement of the lung apex and diaphragmatic ridge. The diaphragm movement tracking process tracks the movement of the diaphragm and can quantify the amount of up and down movement.

[0078] The lung field movement visualization process tracks signal value patterns including vascular shadows in the lung field and displays the movement of each region associated with breathing as a vector, with the maximum inspiration frame as the reference. This process makes it possible to visualize the movement within the lung field.

[0079] The lung field area measurement process is a process of extracting and determining the lung field contour and measuring the lung field area.

[0080] The tracheal diameter measurement process is a process of extracting the tracheal wall and measuring the change in tracheal diameter caused by breathing.

[0081] The ventilation analysis process visualizes signal changes of lung tissue behavior associated with breathing, making it possible to visualize the respiratory state of a patient.

[0082] Blood flow analysis is a process for visualizing signal changes within the lung field that are synchronized with the heartbeat, making it possible to visualize the movement of blood flow within the lung field.

[0083] The second blood flow analysis process visualizes the amount of change in high-frequency signals in the lung field that are synchronized with the heartbeat. The second blood flow analysis process can express smaller changes in blood flow than the blood flow analysis process.

[0084] FIG. 6 shows the correspondence between various chest diseases and dynamic analyses effective for diagnosing those diseases. When a subject suffers from lung cancer, analysis using chest bone attenuation processing has been found to be effective. When a subject suffers from chronic obstructive pulmonary disease (COPD), analysis using frequency emphasis processing, lung field area measurement processing, tracheal diameter measurement processing, and ventilation analysis processing has been found to be effective. When a subject suffers from adhesions or infiltration, analysis using frequency emphasis processing and lung field movement visualization processing has been found to be effective. When a subject suffers from interstitial pneumonia, analysis using frequency emphasis processing, lung field area measurement processing, and ventilation analysis processing has been found to be effective. When a subject suffers from phrenic nerve paralysis or dyspnea, analysis using diaphragm movement tracking processing has been found to be effective. When a subject suffers from pulmonary embolism or pulmonary hypertension, analysis using blood flow analysis processing and second blood flow analysis processing has been found to be effective. As such, the type and combination of dynamic analyses that are effective vary depending on the predicted disease.

[0085] Furthermore, when a subject's disease cannot be predicted in advance, the type and combination of dynamic analyses may be preset, for example, depending on the physician diagnosing the subject. Alternatively, the type and combination of dynamic analyses may be preset, for example, depending on the facility or department to which the physician diagnosing the subject belongs. As a specific example, depending on the physician, facility, or department, the type and combination of dynamic analyses to be performed first when a subject's disease cannot be identified in advance may be determined. In such cases, the type and combination of dynamic analyses to be performed may be determined for each physician, facility, or department diagnosing the subject based on the circumstances leading up to the subject's dynamic analysis. The circumstances leading up to the subject's dynamic analysis include, for example, multiple circumstances, such as whether the subject was transported by ambulance, whether they had a fever, whether they were coughing, or whether they hit their head.

[0086] The type of dynamic analysis to be performed in the next dynamic imaging is included in the imaging order information. Therefore, in step S1, the operator performs a setting process for selecting and setting an effective dynamic analysis from among the multiple types of dynamic analysis that can be performed by the radiation image processing system 100, based on the imaging order information, in the radiation imaging control device 20. The setting process in step S1 is performed, for example, by the operator operating the operation unit 23 of the radiation imaging control device 20.

[0087] For example, if the subject's disease is predicted to be COPD, the operator selects a combination of frequency emphasis processing, lung field area measurement processing, tracheal diameter measurement processing, and ventilation analysis processing by operating the operation unit 23. On the other hand, if the subject's disease is predicted to be interstitial pneumonia, the operator selects a combination of frequency emphasis processing, lung field area measurement processing, and ventilation analysis processing.

[0088] Based on the operation of the operator, the radiography control device 20 generates setting information indicating the setting of a combination of multiple types of dynamic analyses. The radiography control device 20 transmits the generated setting information and radiography order information previously acquired from the RIS or the like to the radiographic image capturing device 10.

[0089] In step S2, the radiographic imaging apparatus 10 determines imaging conditions based on the setting information and imaging order information.

[0090] The imaging conditions to be applied during dynamic imaging vary depending on the type of dynamic analysis to be performed. Information regarding the imaging conditions corresponding to each dynamic analysis is stored in advance in the storage unit 114 of the radiographic imaging device 10. In step S2, the setting information acquisition unit 111 acquires the setting information from the radiographic imaging control device 20, and the imaging condition determination unit 112 determines the imaging conditions to be applied to the next dynamic imaging to be performed by referring to the storage unit 114 based on the setting information.

[0091] As described above, the imaging conditions include various conditions such as the pulse rate, pulse width, pulse interval, number of frames per imaging, radiation dose per unit time, and the subject's physical condition. The subject's physical condition refers to the physical state the subject should assume during dynamic imaging. In dynamic chest imaging, the subject's physical condition includes the subject's respiratory state, such as quiet breathing, breath holding, or deep breathing.

[0092] For example, dynamic analyses such as ventilation analysis and tidal volume measurement require dynamic images generated by having the subject breathe quietly. Dynamic analyses such as blood flow analysis and second blood flow analysis require dynamic images generated by having the subject temporarily suspend breathing (hold their breath). Lung field area measurement requires dynamic images generated by having the subject take a deep breath and then temporarily suspend breathing (hold their breath). Dynamic analyses such as lung field movement visualization, ventilation analysis, diaphragm movement tracking, and tracheal diameter measurement require dynamic images generated by having the subject breathe deeply. However, each dynamic analysis does not necessarily require dynamic images of the respiratory states described above, and the analysis itself is not impossible even if dynamic images of other respiratory states are used. For example, it is possible to perform the dynamic analysis of the second blood flow analysis using dynamic images during deep breathing.

[0093] In this way, imaging conditions corresponding to the dynamic analyses included in a specific combination of multiple types of dynamic analyses may be set in advance for that specific combination, and dynamic imaging may be performed using the imaging conditions set in advance according to the combination. The settings of imaging conditions corresponding to the dynamic analyses included in that specific combination may be stored in advance in, for example, the storage unit 114.

[0094] In step S3, the radiographic imaging device 10 generates a dynamic image of the subject based on the determined imaging conditions and imaging order information.

[0095] In step S3, first, the display device 15 and audio device 16 confirm the name of the subject and instruct the subject on how to position and what posture to take, based on the imaging conditions and imaging order information. When the sensors included in the radiographic imaging device 10 detect that the subject has taken the required posture and is in the appropriate position, the image generation unit 113 performs dynamic imaging based on the imaging conditions. The sensors are provided, for example, on a belt that secures the subject's body. Here, if it is necessary to change the subject's physical condition during dynamic imaging, the display device 15 and audio device 16 instruct the subject to change their body orientation and posture. The image generation unit 113 repeats instructions and dynamic imaging based on the imaging order information until the dynamic imaging to be performed on the subject is completed.

[0096] Here, the operation of step S3 when performing dynamic imaging in three breathing states, namely, quiet breathing, breath holding, and deep breathing, will be described using specific examples as examples of physical conditions. FIG. 7 is a conceptual diagram showing the relationship between elapsed time and breathing depth when dynamic imaging is performed consecutively in the three breathing states, namely, quiet breathing, breath holding, and deep breathing. First, the display device 15 and audio device 16 instruct the subject to rest and breathe normally in order to perform dynamic imaging during quiet breathing. Then, the image generation unit 113 performs dynamic imaging based on imaging conditions corresponding to quiet breathing.

[0097] When the image generating unit 113 has generated a dynamic image during quiet breathing, the display device 15 and audio device 16 then instruct the subject to hold their breath in order to perform dynamic imaging during breath holding. Here, the display device 15 and audio device 16 may instruct the subject to inhale and then hold their breath, or to exhale and then hold their breath. Then, the image generating unit 113 performs dynamic imaging based on imaging conditions corresponding to breath holding.

[0098] When the image generating unit 113 has generated a dynamic image during breath holding, the display device 15 and the audio device 16 then instruct the subject to take a deep breath. The image generating unit 113 then performs dynamic imaging based on imaging conditions corresponding to breath holding. While instructing the breathing states in the order of quiet breathing, breath holding, and deep breathing can be performed to minimize the burden on the subject, the breathing states do not necessarily have to be instructed in the order of quiet breathing, breath holding, and deep breathing, and the order of instructions may be changed. Furthermore, for example, if the subject is elderly or a COPD patient, breath holding may be difficult. In such cases, breath holding may not be instructed. In this way, it is possible to not instruct any of the breathing states depending on the subject's symptoms, physical condition, etc.

[0099] If dynamic imaging under different imaging conditions is required for each physical state, the image generating unit 113 may perform imaging by changing, for example, the pulse rate, pulse width, pulse interval, etc. in accordance with each dynamic analysis while the display device 15 and the audio device 16 are instructing one respiratory state. For example, if dynamic imaging is required for ventilation analysis processing and diaphragm movement tracking processing during deep breathing, the image generating unit 113 may perform imaging at a pulse rate, pulse width, and pulse interval corresponding to each ventilation analysis processing and diaphragm movement tracking processing while the display device 15 and the audio device 16 are instructing deep breathing.

[0100] By performing such operations, dynamic imaging for multiple types of dynamic analysis can be performed on one subject at a time.

[0101] In the above example, the imaging conditions are changed for each type of dynamic analysis for one physical condition. However, for example, imaging conditions may be determined to some extent for each physical condition, regardless of the type of dynamic analysis. For example, imaging conditions may be set so that dynamic imaging is performed at a relatively low pulse rate and a relatively low dose during quiet breathing, regardless of the type of dynamic analysis, and imaging conditions may be set so that dynamic imaging is performed at a higher pulse rate and a relatively high dose during breath holding, compared to quiet breathing. In this case, information regarding imaging conditions to be set according to the physical condition of the subject may be stored in advance in the storage unit 114.

[0102] Furthermore, instead of always using the same imaging conditions for dynamic imaging for one type of dynamic analysis, the imaging conditions for a specific type of dynamic analysis among multiple types of dynamic analysis may be varied based on the types of other dynamic analyses included in the combination. In other words, even for the same type of dynamic analysis, the imaging conditions may be changed depending on the type of the other dynamic analysis to be combined.

[0103] A specific example will be given. For example, consider the case where the second blood flow analysis process is combined with a ventilation analysis process. The second blood flow analysis process usually requires dynamic images taken during breath-holding, and the ventilation analysis process usually requires dynamic images taken during deep breathing. In such a case, the dynamic analysis used in the combination of the second blood flow analysis process and the ventilation analysis process can be performed using dynamic images taken while the subject is holding their breath after taking a deep breath. In this way, by performing a combination of multiple types of dynamic analysis using dynamic images taken under imaging conditions that satisfy as many imaging conditions as possible required for each dynamic analysis, it is possible to perform a dynamic analysis with high accuracy.

[0104] Conversely, a dynamic analysis combining multiple types of analysis may be performed using dynamic images that satisfy only the imaging conditions of the dynamic analysis to be combined. For example, the second blood flow analysis process typically requires dynamic images during breath-holding. However, if the combined dynamic analysis requires dynamic images during deep breathing, such as a ventilation analysis process, dynamic images during deep breathing may be used as the dynamic images for the second blood flow analysis process, rather than dynamic images during breath-holding. In other words, if the combination includes the second blood flow analysis process and the ventilation analysis process, the combined dynamic analysis may be performed using images captured under imaging conditions suited to the ventilation analysis process (images captured with a relatively low pulse rate and a relatively low dose while the subject is instructed to take deep breaths). This makes it possible to perform a dynamic analysis including the second blood flow analysis process even on subjects who have difficulty holding their breath.

[0105] Varying the imaging conditions for a specific type of dynamic analysis based on the types of other dynamic analyses included in the combination is useful, for example, from the perspective of being able to appropriately set the imaging conditions depending on the physical strength and condition of the subject. For example, breath-holding is a significant burden on subjects with relatively low physical strength (such as elderly people or patients transported by ambulance), so dynamic analyses that include breath-holding as an imaging condition are difficult to perform on subjects with relatively low physical strength. Therefore, when performing a dynamic analysis that combines the second blood flow analysis process and the ventilation analysis process on a relatively young subject with relatively high physical strength, accurate analysis can be performed by using dynamic images captured under imaging conditions that satisfy as many of the imaging conditions of the second blood flow analysis process and the ventilation analysis process as possible. On the other hand, when the second blood flow analysis process is required for a subject who has difficulty holding their breath, an analysis that places less strain on the subject can be performed by combining a ventilation analysis process that does not include breath-holding as an imaging condition and using dynamic images captured under imaging conditions that satisfy at least one of the imaging conditions of the second blood flow analysis process and the ventilation analysis process.

[0106] Note that the image generating unit 113 may generate, for each generated frame image during dynamic imaging, imaging information indicating the imaging conditions under which the frame image was captured, in association with the image. Furthermore, the image generating unit 113 may use a sensor or the like of the radiographic imaging device 10 to acquire information indicating whether the subject is correctly assuming the required physical state when capturing each frame image, and may include the information in the imaging information and associate it with each frame image. In this case, for example, the radiographic imaging device 10 may have a sensor for detecting the subject's respiratory state, etc., attached to a belt or the like for securing the subject's body during imaging, and the radiographic imaging device 10 may detect the subject's respiratory state during dynamic imaging based on the detection result of the sensor.

[0107] In the above example, the display device 15 and the audio device 16 automatically give various instructions to the subject regarding the dynamic imaging to be performed based on the setting conditions and imaging order information. In the present disclosure, the display device 15 and the audio device 16 do not have to automatically give various instructions in this manner. For example, the operator may give various instructions to the subject verbally or by gestures while checking the setting conditions and imaging order information displayed on the display unit 24 of the radiation imaging control device 20.

[0108] The dynamic image generated in step S3 is transmitted from the radiation image capturing apparatus 10 to the radiation image analyzing apparatus 30 via the radiation imaging control apparatus 20.

[0109] In step S4, the radiographic image analyzer 30 extracts frame images necessary for each dynamic analysis to be performed from the dynamic images received from the radiographic image capturing apparatus 10.

[0110] As described above, dynamic analysis during quiet breathing requires dynamic images during quiet breathing. Dynamic analyses such as blood flow analysis processing and second blood flow analysis processing require dynamic images during breath holding. Dynamic analyses such as ventilation analysis processing, diaphragm movement tracking processing, and tracheal diameter measurement processing require dynamic images during deep breathing.

[0111] Therefore, if the combination set in step S1 includes a blood flow analysis process, a frame image corresponding to breath holding is extracted in step S4. Also, if the combination set in step S1 includes a ventilation analysis process, a frame image corresponding to deep breathing is extracted in step S4. Which frame image corresponds to breath holding or deep breathing can be determined based on the imaging information associated with each frame image.

[0112] Furthermore, depending on the type of dynamic analysis, frame images with a narrower range may be extracted. For example, in ventilation analysis processing (visualization of lung tissue behavior) or diaphragm movement tracking processing (quantification of diaphragm displacement), theoretically, a frame image at maximum inspiration and a frame image at maximum expiration during deep breathing are sufficient, and other frame images are not required. Therefore, when ventilation analysis processing or diaphragm movement tracking processing is selected, for example, several frame images including maximum inspiration and several frame images including maximum expiration may be extracted from the multiple frame images captured during deep breathing. Note that which frame images of the multiple frame images captured during deep breathing correspond to maximum inspiration and which frame images correspond to maximum expiration may be determined based on imaging information generated during dynamic imaging.

[0113] Furthermore, in step S3, the extraction of frame images used for a specific type of dynamic analysis among multiple types of dynamic analysis may be varied based on the types of other dynamic analyses included in the combination.

[0114] A specific example will be described. When a combination of ventilation analysis processing and diaphragm movement tracking processing is set, the radiographic image analysis device 30 extracts several frame images before and after maximum inspiration and several frame images before and after maximum expiration as frame images used in the ventilation analysis processing. On the other hand, when a combination of ventilation analysis processing and tracheal diameter measurement processing is set, the radiographic image analysis device 30 may extract all frame images generated in a deep breathing state as frame images used in the ventilation analysis processing. The reason for extracting all frame images in a combination of ventilation analysis processing and tracheal diameter measurement processing is that all frame images in a deep breathing state are required for the combined tracheal diameter measurement processing (a mode for measuring tracheal diameter). However, in addition to extracting frame images used in the ventilation analysis processing, the radiographic image analysis device 30 also extracts frame images used in the combined dynamic analysis (diaphragm movement tracking processing or tracheal diameter measurement processing in the above example). The radiographic image analysis device 30 may perform analysis using the same or different frame images for each dynamic analysis included in the combination.

[0115] In this way, in step S4, necessary frame images are extracted for each dynamic analysis included in the combination of multiple types of dynamic analyses set in step S1.

[0116] In step S5, the radiographic image analyzer 30 performs each of the multiple types of dynamic analyses included in the combination set in step S1 using the frame images extracted for each dynamic analysis in step S4. For example, the analysis unit 312 of the radiographic image analyzer 30 performs the dynamic analysis automatically using a predetermined parameter group, or using a parameter group set by an operator. Specific examples of dynamic analysis include well-known dynamic analyses such as ventilation analysis and pulmonary blood flow analysis described in, for example, Japanese Patent Application Laid-Open No. 2012-110451.

[0117] In step S6, the results of the dynamic analysis performed in step S5 are output in the radiographic image analyzer 30. The analysis results are output, for example, by displaying the results of the dynamic analysis on the display unit 34. Alternatively, the analysis results are output by transmitting analysis result information indicating the results of the dynamic analysis to a terminal device used by a doctor or the like via the communication unit 35. This allows the doctor or the like who requested the dynamic imaging and dynamic analysis to make a diagnosis or the like based on the analysis results.

[0118] 5, an example has been described in which dynamic images to be used for each dynamic analysis are captured based on the imaging conditions of the multiple types of dynamic analysis included in the combination. In the present disclosure, for example, dynamic images may be captured under imaging conditions that can accommodate any combination of dynamic analyses.

[0119] A specific example will be given below. Assume that the multiple types of dynamic analyses that can be performed by the radiographic image analysis device 30 use, for example, at least one of dynamic images captured while the subject is at rest, dynamic images captured while the subject is taking a deep breath, and dynamic images captured while the subject is holding their breath. In this case, in step S2, the radiographic image capturing device 10 may set the imaging conditions to include all imaging conditions so that any dynamic analysis can be performed, regardless of the combination set in step S1.

[0120] In this case, in step S4, the radiographic image analyzer 30 extracts frame images to be used for each dynamic analysis according to the imaging conditions of the dynamic images required for the dynamic analysis included in the combination. Even with this operation, the radiographic image processing system 100 can smoothly perform dynamic analysis that combines multiple types of images.

[0121] <Actions and Effects> As described above, in the radiation image processing system 100 according to an embodiment of the present disclosure, a combination of multiple types of dynamic analyses is set before dynamic imaging begins, and based on the setting conditions indicating the combination, dynamic imaging is performed under imaging conditions corresponding to each dynamic analysis included in the combination, and based on the dynamic image generated by the dynamic imaging, multiple types of dynamic analyses included in the combination are executed.

[0122] With this configuration, the radiation image processing system 100 makes it possible to perform multiple types of dynamic analyses as a series of operations, for example, when multiple types of dynamic analyses are required for diagnosing a subject. This allows, for example, when a specific disease is suspected based on the patient's symptoms, multiple types of dynamic analyses effective for the suspected disease to be performed at once. This reduces the workload required of the operator of the radiation image processing system 100 when performing multiple types of dynamic analyses. Furthermore, compared to performing multiple types of dynamic imaging separately, the time required to restrain the subject for dynamic imaging can be shortened, thereby reducing the burden on the subject.

[0123] <Modification> In the above-described embodiment, a preferred example of the present disclosure has been described, but the present disclosure is not limited to the above-described embodiment. Various modifications of the present disclosure are possible within the scope of the claims.

[0124] In the above-described embodiment, a case where dynamic chest images are captured and dynamic chest analysis is performed has been described as an application example of the radiation image processing system of the present disclosure. However, the radiation image processing system of the present disclosure is not limited to this, and may also perform dynamic imaging and dynamic analysis of other body parts.

[0125] <Variation 1> For example, the heart of a subject may be the subject of dynamic imaging and dynamic analysis. In this case, the type of dynamic analysis may be different from that described in the above embodiment, which targets the lungs. However, since the second blood flow analysis process visualizes the amount of change in high-frequency signals in the lung field synchronized with the heartbeat, it can be performed even when the heart is the subject.

[0126] When the subject's heart is subjected to dynamic imaging and dynamic analysis, when extracting frame images necessary for dynamic imaging from the generated dynamic image, frame images that do not contain arrhythmia (bradycardia, tachycardia, premature contraction, etc.) may be extracted for dynamic analysis. Known image analysis techniques can be applied to the method of extracting frame images containing arrhythmia.

[0127] <Variation 2> For example, the subject's throat and esophagus may be the subject of dynamic imaging and dynamic analysis. This is useful for diagnosing the subject's swallowing ability, etc. The imaging conditions may include the subject's swallowing a contrast agent or the like as a physical condition. In this case, when extracting frame images necessary for dynamic imaging from the generated dynamic images, frame images in which the contrast agent passes through the throat may be separated from frame images in which the contrast agent does not, and each may be used for separate dynamic analyses. Furthermore, frame images in which the contrast agent passes through the throat may be extracted separately from frame images before and after the contrast agent passes through the throat. In this case, it is possible to evaluate whether or not something swallowed has refluxed.

[0128] Furthermore, a frame image may be extracted each time the contrast agent passes through the throat. Specifically, a frame image in which the contrast agent passes through the nasopharynx, a frame image in which the contrast agent passes through the oropharynx, and a frame image in which the contrast agent passes through the hypopharynx may be extracted. This allows for accurate analysis of the subject's swallowing ability.

[0129] <Variation 3> For example, the subject's joints (elbows, knees, waist, neck, etc.) may be the subject of dynamic imaging and dynamic analysis. In this case, for example, frame images at maximum flexion and frame images at maximum extension may be extracted separately. [Industrial Applicability]

[0130] The present invention is suitable for a radiation image processing system capable of performing various dynamic analyses. [Explanation of symbols]

[0131] 100 Radiation image processing system 10 Radiation imaging device 11. Shooting control device 111 Setting information acquisition unit 112 Shooting condition determination unit 113 Image Generation Unit 114 Storage section 12 Radiation irradiation equipment 13 Photo stand 14 Radiation detection unit 16 Audio equipment 20 Radiography control device 21 Control section 22 Memory section 23 Control section 24 Display section 25 Communications Department 26 Bus 30 Radiation image analysis device 31 Control Unit 311 Image Acquisition Unit 312 Analysis Department 32 Storage section 33 Operation section 34 Display section 35 Communications Department 36 Bus 40 Image management device 50 client terminals

Claims

1. acquiring a plurality of frame images generated by performing dynamic imaging by irradiating a subject with radiation under imaging conditions corresponding to a combination of a plurality of types of dynamic analysis that have been set in advance; performing the plurality of types of dynamic analyses included in the combination based on the plurality of frame images; A radiological image analysis program that runs the following on a computer.

2. The step of performing the kinetic analysis includes: extracting a frame image to be used for each of the dynamic analyses included in the combination from the plurality of frame images; performing the dynamic analysis based on the extracted frame images; The radiological image analysis program according to claim 1 , comprising:

3. The step of extracting the frame image includes: extracting the frame images used for a specific type of dynamic analysis among the plurality of types of dynamic analysis based on the types of other dynamic analyses included in the combination; The radiographic image analysis program according to claim 2 .

4. acquiring setting information regarding a combination of multiple types of dynamic analyses; determining imaging conditions for dynamic imaging based on the setting information; performing dynamic imaging of the subject by irradiating the subject with radiation based on the determined imaging conditions, and generating a plurality of frame images; A radiographic imaging program that causes a computer to execute the above.

5. The step of determining the imaging conditions includes: determining the imaging conditions based on the types of the dynamic analysis included in the combination; The radiographic imaging program according to claim 4 .

6. The step of determining the imaging conditions includes: varying imaging conditions for a specific type of dynamic analysis among the plurality of types of dynamic analysis based on the types of other dynamic analysis included in the combination; The radiographic imaging program according to claim 5 .

7. The computer included in the radiation image analysis device is Acquiring a plurality of frame images generated by performing dynamic imaging by irradiating radiation on the subject under imaging conditions corresponding to a combination of a plurality of types of dynamic analysis that have been set in advance; performing the plurality of types of dynamic analyses included in the combination based on the plurality of frame images; Radiographic image analysis methods.

8. A computer included in a radiographic imaging device, acquiring setting information regarding a combination of multiple types of dynamic analyses using the radiographic images; determining imaging conditions for performing dynamic imaging by irradiating radiation onto the subject based on the setting information; performing the dynamic imaging of the subject based on the determined imaging conditions to generate a plurality of frame images; Radiography imaging method.

9. an image acquisition unit that acquires a plurality of frame images generated by performing dynamic imaging by irradiating a subject with radiation under imaging conditions corresponding to a combination of a plurality of types of dynamic analysis that have been set in advance; an analysis unit that executes the plurality of types of dynamic analyses included in the combination based on the plurality of frame images; A radiation image analysis device comprising:

10. a setting information acquisition unit that acquires setting information regarding a combination of multiple types of dynamic analyses; an imaging condition determination unit that determines imaging conditions for dynamic imaging based on the setting information; an image generating unit that performs the dynamic imaging of the subject by irradiating the subject with radiation based on the determined imaging conditions and generates a plurality of frame images; A radiation image capturing device comprising:

11. The radiological image analysis device according to claim 9 ; The radiographic imaging device according to claim 10; A radiation imaging system comprising:

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