State improvement promotion device and state improvement promotion method

Abstract

To provide a state improvement promotion device and a state improvement promotion method capable of improving microcirculation of intracerebral tissue and improving dementia.SOLUTION: A scattering induction unit that induces scattering of an ultrasonic vibration and a low-frequency vibration is attached to a contact portion with an outer surface of a head of the subject in a vibration generation unit that generates the ultrasonic vibration and the low-frequency vibration having a vibration frequency of 100 [Hz] or less, and the vibration generation unit is driven and controlled so that vibration energy of the ultrasonic vibration and the low-frequency vibration propagates to an entire target region in a brain of the subject.SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] The present invention aims to propose a condition improvement promotion device and a condition improvement promotion method that promote improvement of microcirculation in the brain tissue of a subject and improvement of dementia in the subject by physical stimulation, particularly through ultrasonic vibrations or low-frequency vibrations. [Background technology]

[0002] As Japan's population ages, the number of dementia patients in the country is on the rise. In particular, vascular dementia and Alzheimer's disease account for the majority of dementia cases, and many patients exhibit symptoms of both diseases.

[0003] Common methods of treating vascular dementia include drug treatment for high blood pressure, dyslipidemia, and diabetes, as well as promoting exercise, quitting smoking, preventing overeating, and reducing stress. However, no pharmaceutical treatment for vascular dementia itself has yet been developed.

[0004] In recent years, a method for treating dementia has been proposed in which low-intensity pulsed ultrasound (LIPUS) is irradiated onto the brain with the aim of inducing vascularization and neuronal proliferation in the human brain (see Patent Document 1).

[0005] This dementia treatment involves irradiating low-intensity pulsed ultrasound, which increases the expression of endothelial nitric oxide synthase (eNOS) through a mechanism mediated by physical stimulation of the caveolin-1 / β-integrin complex present in the vascular endothelial cell membrane. As a result, downstream effects include a reduction in amyloid-β accumulation, inhibition of microglial activity, angiogenesis, and remyelination, resulting in a treatment that suppresses cognitive decline through a complex mechanism of action. [Prior art documents] [Patent documents]

[0006] [Patent Document 1] Patent Publication No. 2018-181991 Summary of the Invention [Problem to be solved by the invention]

[0007] Incidentally, the dementia treatment method described in Patent Document 1 is a method in which, with multiple ultrasonic probes placed on the surface of the head, unfocused ultrasonic energy that diffuses in an inverse tapered shape between the multiple ultrasonic probes is sequentially irradiated at intervals of 0.15 / f ms or more (f indicates the frequency (MHz) of the transmitted pulse).

[0008] However, in this dementia treatment method, where ultrasound waves are attenuated as they propagate through the brain and as they reflect off the skull, a method in which unfocused ultrasound energy is sequentially irradiated between multiple ultrasound probes at predetermined time intervals can prevent excessive ultrasound stimulation even if the unfocused ultrasound energy generated one after the other overlaps, but further ingenuity is needed to efficiently propagate vibration energy throughout the target area in the brain.

[0009] The present invention has been made in consideration of the above points, and aims to propose a condition improvement promotion device and a condition improvement promotion method that can improve microcirculation in brain tissue and improve dementia. [Means for solving the problem]

[0010] In order to solve such problems, in the present invention, a condition improvement promotion device for improving the microcirculation in the brain tissue of a subject and promoting the improvement of dementia in the subject is provided with a vibration generating unit that generates ultrasonic vibrations and low-frequency vibrations with a vibration frequency of 100 Hz or less, a scattering inducing unit that is attached to the contact point of the vibration generating unit with the outer surface of the subject's head and induces scattering of the ultrasonic vibrations and low-frequency vibrations, and a control unit that drives and controls the vibration generating unit so that the vibration energy of the ultrasonic vibrations and low-frequency vibrations is propagated throughout the target area in the subject's brain.

[0011] In this way, with the condition improvement promotion device, the subject wears the vibration generating unit on their head via the scattering inducing unit, and ultrasonic vibrations and low-frequency vibrations are scattered and irradiated, thereby propagating vibration energy throughout the target area in the brain and activating a complex mechanism of action within the brain, thereby improving microcirculation in brain tissue and making it possible to alleviate dementia.

[0012] In addition, in the present invention, the vibration generating units are attached so that multiple units are arranged around the subject's head, and the control unit drives and controls each of the vibration generating units so that a phase difference occurs between the ultrasonic vibrations and low-frequency vibrations from each vibration generating unit.

[0013] As a result, in the condition improvement promotion device, by irradiating multiple ultrasonic vibrations and low-frequency vibrations with a phase difference that are propagated into the subject's brain, it is possible for the vibration energy that passes through the brain to propagate throughout the entire target area within the brain without resonating.

[0014] Furthermore, the present invention further includes a vibration receiving unit that receives ultrasonic vibrations and low-frequency vibrations transmitted through the contact point with the outer surface of the subject's head, and the control unit constantly monitors the intensity of the vibration energy of the ultrasonic vibrations and low-frequency vibrations received by the vibration receiving unit to maintain it below a predetermined level while controlling the drive of the vibration generating unit when the intensity is above a predetermined level.

[0015] As a result, the condition improvement promotion device constantly monitors the vibration energy of the ultrasonic vibrations and low-frequency vibrations propagated into the subject's brain to ensure that it does not become excessive, thereby preventing any adverse effects on the subject's brain caused by the application of this device and ensuring safety.

[0016] Furthermore, in the present invention, the scattering induction section is made up of a thin, envelope-like body containing fine particles of ultrasound scatterers having predetermined scattering properties scattered throughout a liquid, gel, or polymer medium.

[0017] As a result, in the condition improvement promotion device, when the subject wears the vibration generating unit on his or her head, the scattering inducing unit that is inserted between the vibration generating unit and the contact point on the outer surface of the head is made of a relatively flexible object, thereby making it possible to reduce discomfort to the subject's head.

[0018] Furthermore, in the present invention, the scattering-inducing section comprises a thin, envelope-like body containing point-like scatterers made of gas bubbles scattered throughout the liquid medium, and the control section controls either or both of the arrangement and distribution state of the point-like scatterers in the scattering-inducing section to a desired state, thereby adjusting the scattering characteristics of the ultrasonic vibrations and low-frequency vibrations.

[0019] As a result, the condition improvement promotion device can adjust the scattering characteristics of the scattering induction part that is abutted against the contact point on the outer surface of the subject's head to the desired state, making it possible to optimize the propagation state of vibration energy throughout the target area within the brain.

[0020] Furthermore, in the present invention, the scattering induction section consists of a thin, envelope-like body filled with magnetic fluid, and the control section controls either or both of the arrangement and distribution state of the ferromagnetic microparticles contained in the magnetic fluid in the scattering induction section to a desired state, thereby adjusting the scattering characteristics of the ultrasonic vibrations and low-frequency vibrations.

[0021] As a result, the condition improvement promotion device can adjust the scattering characteristics of the scattering induction part that is abutted against the contact point on the outer surface of the subject's head to the desired state, making it possible to optimize the propagation state of vibration energy throughout the target area within the brain.

[0022] Furthermore, in the present invention, the vibration energy of the ultrasonic vibration and low-frequency vibration generated by the vibration generating unit has a vibration generating sound pressure of 0.1 to 1.5 MPa, and the irradiation time for a single use on the subject is set to a maximum of 20 minutes, and in the case of repeated use, the upper limit is set to a total of 60 minutes of irradiation per day with a 5-minute interval.

[0023] In this way, with the condition improvement promotion device, the sound pressure generated by the piezoelectric vibrator in the vibration generating unit is set within a range that gives the brain an appropriate tissue amplitude, and by setting a limit on the irradiation time for a single use and also setting an upper limit on the sense of time when repeated use and the total time per day, it is possible to maintain the effect of improving the microcirculation of the subject's brain tissue and the effect of suppressing the decline in cognitive function for a relatively long period of time, for more than three months after use.

[0024] Furthermore, in the present invention, the vibration energy of the ultrasonic vibrations and low-frequency vibrations generated by the vibration generating unit is dispersed in all directions while scattering from the direction of irradiation, and the ultrasonic and low-frequency vibrations stimulate vascular cells, promoting the expression of eNOS (endothelial nitric oxide synthase), VEGF (vascular endothelial growth factor), and bFGF (basic fibroblast growth factor).

[0025] In this way, the condition improvement promotion device scatters the vibration energy of ultrasonic vibrations and low-frequency vibrations in all directions while scattering them from the direction of irradiation, thereby enhancing the expression of eNOS (endothelial nitric oxide synthase), VEGF (vascular endothelial growth factor), and bFGF (basic fibroblast growth factor), thereby achieving an improvement in the microcirculation of the subject's brain tissue and an improvement in dementia.

[0026] Furthermore, in the present invention, in a method for promoting improvement of a condition to improve the microcirculation in the brain tissue of a subject and promote improvement of dementia in the subject, a scattering inducing unit that induces scattering of the ultrasonic vibrations and low-frequency vibrations is attached to a vibration generating unit that generates ultrasonic vibrations and low-frequency vibrations with a vibration frequency of 100 Hz or less at a contact site with the outer surface of the subject's head, and the vibration generating unit is driven and controlled so that the vibration energy of the ultrasonic vibrations and low-frequency vibrations is propagated throughout the entire target area in the subject's brain.

[0027] In this method for promoting improvement of a condition, the subject wears the vibration generating unit on his or her head via the scattering inducing unit, and ultrasonic vibrations and low-frequency vibrations are scattered and irradiated, thereby propagating vibration energy throughout the target area in the brain and activating a complex mechanism of action within the brain, thereby improving microcirculation in brain tissue and alleviating dementia. [Effects of the Invention]

[0028] According to the present invention, it is possible to realize a condition improvement promotion device and a condition improvement promotion method that can efficiently propagate vibration energy throughout the target area in the brain, activate a complex mechanism of action in the brain, improve microcirculation in brain tissue, and improve dementia. [Brief explanation of the drawings]

[0029] [Figure 1] 1 is an external perspective view showing the configuration of a condition improvement promotion device according to an embodiment of the present invention; [Figure 2] 2 is a conceptual diagram showing a circuit configuration of a control system in the condition improvement promoting device shown in FIG. 1. FIG. [Figure 3] FIG. 10 is a conceptual diagram showing the circuit configuration of a control system in a condition improvement promoting device when a scattering inducing unit of a second embodiment is applied. [Figure 4] FIG. 10 is a conceptual diagram showing the circuit configuration of a control system in a condition improvement promoting device when a scattering inducing unit of a third embodiment is applied. DETAILED DESCRIPTION OF THE INVENTION

[0030] An embodiment of the present invention will be described in detail below with reference to the drawings.

[0031] (1) Configuration of the condition improvement promotion device according to this embodiment 1 is a schematic external view of a condition improvement promotion device 1 according to this embodiment. This condition improvement promotion device 1 has a pair of vibration generating units 2 to be attached to the outer surface of the subject's head, and a control unit 3 for driving and controlling each of the vibration generating units 2. The pair of vibration generating units 2 and the control unit 3 are connected to each other via wire or wirelessly so that they can communicate with each other.

[0032] The pair of vibration generating units 2 consist of piezoelectric vibrators (piezoelectric ceramic vibrators, piezoelectric single crystal vibrators, polymer piezoelectric film vibrators, etc.) or magnetostrictive vibrators (ferrite magnetostrictive vibrators, etc.) that generate ultrasonic vibrations and low-frequency vibrations with a vibration frequency of 100 Hz or less.

[0033] Each pair of vibration generating units 2 is fitted with a scattering inducing unit 4 at the contact point with the outer surface of the subject's head to induce scattering of the ultrasonic vibrations and low-frequency vibrations generated from each piezoelectric vibrator (or magnetostrictive vibrator).

[0034] The subject wears the pair of vibration generating units 2 of the condition improvement promotion device 1 so that the scattering inducing units 4 are in contact with the left and right temporal bones (temples), which are the thinnest parts of the skull in the subject's head. By selecting the temporal bones (temples) as the contact points with the outer surface of the head, it is possible to relatively improve the transmission efficiency of ultrasonic vibrations and low-frequency vibrations to the brain.

[0035] In this way, with the condition improvement promotion device 1, the subject wears the vibration generating unit 2 on their head via the scattering inducing unit 4, and ultrasonic vibrations and low-frequency vibrations are scattered and irradiated, thereby propagating vibration energy throughout the target area in the brain and activating a complex mechanism of action within the brain, thereby improving microcirculation in brain tissue and making it possible to alleviate dementia.

[0036] (2) Method for controlling the drive of a pair of vibration generating units Figure 2 shows the circuit configuration of the control system in the condition improvement promotion device 1. The condition improvement promotion device 1 has a control unit 3 that includes a general control unit 10 that controls the entire device and is made up of an MCM (Multi-Chip Module) equipped with a CPU (Central Processing Unit), memory, etc., and a memory unit 11 that reads and writes various data under the control of the general control unit 10.

[0037] The general control unit 10 controls the driving of each vibration generating unit 2 so that the vibration energy of the ultrasonic vibration and the low-frequency vibration is propagated to the entire target region in the brain of the subject.

[0038] According to experiments, the conditions for the vibration energy of the ultrasonic vibration and low-frequency vibration generated by the vibration generating unit 2 are set as follows: the vibration generation sound pressure is 0.1 to 1.5 MPa, the irradiation time for a single use on the subject is set to a maximum of 20 minutes, and in the case of repeated use, the irradiation time is set to a maximum of 60 minutes in total per day with a 5-minute interval.

[0039] In this way, in the condition improvement promotion device 1, the sound pressure generated by the piezoelectric vibrator (or magnetostrictive vibrator) in the vibration generating unit 2 is set within a range that gives an appropriate tissue amplitude to the brain, and by setting a limit on the irradiation time for a single use and also setting an upper limit on the sense of time when repeated use and the total time per day, it is possible to maintain the effect of improving the microcirculation of the subject's brain tissue and the effect of suppressing the decline of cognitive function for a relatively long period of time, for more than three months after use.

[0040] The function of promoting improvement of the condition by irradiating the vibration energy of ultrasonic vibrations and low-frequency vibrations generated by the vibration generating unit 2 is that the vibration energy of the ultrasonic vibrations and low-frequency vibrations is scattered in all directions from the direction of irradiation, and the ultrasonic and low-frequency vibrations stimulate the vascular cells in the subject's brain, thereby promoting the expression of eNOS (endothelial nitric oxide synthase), VEGF (vascular endothelial growth factor), and bFGF (basic fibroblast growth factor).

[0041] In this way, the condition improvement promotion device 1 scatters the vibration energy of ultrasonic vibrations and low-frequency vibrations in all directions while scattering them from the direction of irradiation, thereby enhancing the expression of eNOS (endothelial nitric oxide synthase), VEGF (vascular endothelial growth factor), and bFGF (basic fibroblast growth factor), thereby achieving an improvement in the microcirculation of the subject's brain tissue and an improvement in dementia.

[0042] Furthermore, in the condition improvement promotion device 1, the general control unit 10 controls the drive of each of the pair of vibration generating units 2 so that a phase difference occurs between the ultrasonic vibration and the low-frequency vibration, thereby enabling the vibration energy passing through the subject's brain to propagate throughout the entire target area within the brain without resonating.

[0043] Furthermore, the condition improvement promotion device 1 is provided with a vibration receiving unit 12 that receives ultrasonic vibrations and low-frequency vibrations transmitted via contact points with the outer surface of the subject's head near the pair of vibration generating units 2. When the intensity of the vibration energy of the ultrasonic vibrations and low-frequency vibrations received by the vibration receiving unit 12 is equal to or greater than a predetermined level, the overall control unit 10 constantly monitors the vibration generating units 2 while controlling their drive to maintain the intensity below the predetermined level.

[0044] As a result, the condition improvement promotion device 1 constantly monitors the vibration energy of the ultrasonic vibrations and low-frequency vibrations propagated into the subject's brain to ensure that it does not become excessive, thereby preventing any adverse effects on the subject's brain caused by the application of this device and ensuring safety.

[0045] In addition, while irradiating ultrasonic vibration and low-frequency vibration energy from a pair of vibration generating units 2, if the intensity of the ultrasonic vibration and low-frequency vibration energy received by the vibration receiving unit 12 is above a predetermined level, the integrated control unit 10 may constantly monitor the drive and control of the vibration generating units 2 to maintain the intensity below the predetermined level, and may also appropriately change the phase difference of the ultrasonic vibration and low-frequency vibration for both vibration generating units 2.

[0046] (3) Structure of the scattering inducer (3-1) Configuration of the scattering inducer in the first embodiment The scattering inducing section 4 in the first embodiment is made of a thin, envelope-like body containing fine particles made of ultrasound scatterers having predetermined scattering properties scattered throughout a liquid (for example, water), gel, or polymer medium.

[0047] Here, scattering refers to the phenomenon in which reflected waves are scattered in all directions when ultrasonic waves are incident on an irregular boundary surface or a minute reflector. Ultrasonic scatterers may be of various sizes, shapes, and materials, as long as they are particles that can induce forward scattering of ultrasonic vibrations and low-frequency vibrations generated from a vibration generating unit (piezoelectric vibrator or magnetostrictive vibrator).

[0048] As a result, in the condition improvement promotion device 1, when the subject wears the vibration generating unit 2 on his / her head, the scattering inducing unit 4, which is inserted between the vibration generating unit 2 and the contact point on the outer surface of the head, is made of a relatively flexible object, thereby making it possible to reduce discomfort to the subject's head.

[0049] (3-2) Configuration of the scattering inducer in the second embodiment The scattering inducing unit 20 in the second embodiment is made of a thin, plate-like envelope containing point-like scatterers 21 made of gas bubbles scattered throughout a liquid medium. The general control unit 10 adjusts the scattering characteristics of the ultrasonic vibrations and low-frequency vibrations by controlling either or both of the arrangement and distribution of the point-like scatterers 21 in the scattering inducing unit 20 to a desired state (FIG. 3).

[0050] As a result, the condition improvement promotion device 1 can adjust the scattering characteristics of the scattering induction unit 20 that is abutted against the contact area on the outer surface of the subject's head to the desired state, making it possible to optimize the propagation state of vibration energy throughout the target area within the brain.

[0051] (3-3) Configuration of the scattering inducer in the third embodiment The scattering induction unit 30 in the third embodiment is made of a thin, plate-like envelope filled with magnetic fluid 31. The integrated control unit 10 adjusts the scattering characteristics of the ultrasonic vibrations and low-frequency vibrations by controlling either or both of the arrangement and distribution of the ferromagnetic microparticles contained in the magnetic fluid 31 in the scattering induction unit 30 to a desired state (FIG. 4).

[0052] The magnetic fluid 31 is a colloidal solution in which magnetic iron oxide nanoparticles are dispersed extremely stably in a liquid, and is a composite material consisting of magnetic particles (e.g., magnetite (Fe3O4) or maghemite (γ-Fe2O3)) as the dispersoid (solute), a solvent as the dispersion medium (solvent), and ions or surfactants as the dispersants.

[0053] In the absence of an external magnetic field, the magnetic moments of the magnetic particles rotate randomly in the liquid, canceling each other out and resulting in no magnetization of the fluid as a whole. However, in the presence of an external magnetic field, the magnetic moment of each nanoparticle orients itself in the direction of the magnetic field lines, causing the fluid to behave as if it were magnetized.

[0054] Taking advantage of these characteristics of the magnetic fluid, the integrated control unit 10 controls the particle size, particle size distribution, shape and aggregate size of the ferromagnetic microparticles contained in the magnetic fluid 31 in the scattering induction unit 30, thereby controlling either or both of the arrangement and distribution state of the ferromagnetic microparticles to the desired state, thereby adjusting the scattering characteristics of the ultrasonic vibrations and low-frequency vibrations.

[0055] As a result, the condition improvement promotion device 1 can adjust the scattering characteristics of the scattering induction unit 30, which is abutted against the contact area on the outer surface of the subject's head, to the desired state, making it possible to optimize the propagation state of vibration energy throughout the target area within the brain.

[0056] (4) Other embodiments In this embodiment, the condition improvement promotion device 1 has been described as being configured such that the left and right temporal regions (temples) are selected as contact points with the outer surface of the subject's head and a vibration generating unit 2 is attached to each of them, but the present invention is not limited to this, and the number of vibration generating units 2 attached can be freely set to not only two, but also one, or three or more.

[0057] For example, in addition to the left and right temporal regions (temples), the boundary between the occipital region and the top of the head (foramen magnum) may be selected as a contact site with the outer surface of the subject's head.

[0058] Furthermore, in this embodiment, the scattering inducing units 4, 20, 30 have been described as being configured and controlled in the manner described above for the first to third embodiments, but the present invention is not limited to this. In essence, as long as the scattering of the ultrasonic vibrations and low-frequency vibrations irradiated from the vibration generating unit 2 can be induced to a desired state, various scattering inducing units may be applied as long as they are configured to be attachable to the contact point of the vibration generating unit 2 with the outer surface of the subject's head. [Explanation of symbols]

[0059] 1...condition improvement promotion device, 2...vibration generating unit, 3...control unit, 4, 20, 30...scattering induction unit, 10...general control unit, 11...memory unit, 12...vibration receiving unit, 21...point-like scatterer, 31...magnetic fluid.

Claims

1. A condition improvement promotion device for promoting improvement of microcirculation in brain tissue of a subject and improvement of dementia of the subject, a vibration generating unit that generates ultrasonic vibrations and low-frequency vibrations with a vibration frequency of 100 Hz or less; a scattering inducing unit attached to a contact portion of the vibration generating unit with the outer surface of the subject's head, the scattering inducing unit inducing scattering of the ultrasonic vibration and the low-frequency vibration; a control unit that drives and controls the vibration generating unit so that vibration energy of the ultrasonic vibration and the low-frequency vibration is propagated throughout a target region in the brain of the subject; A condition improvement promotion device comprising:

2. the vibration generating unit is attached so that a plurality of the vibration generating units are arranged around the head of the subject, The control unit controls the driving of each of the vibration generating units so that a phase difference occurs between the ultrasonic vibration and the low-frequency vibration.

2. The condition improvement promoting device according to claim 1.

3. a vibration receiving unit that receives the ultrasonic vibration and the low-frequency vibration transmitted through a contact portion with the external surface of the head of the subject; When the intensity of the vibration energy of the ultrasonic vibration and the low-frequency vibration received by the vibration receiving unit is equal to or greater than a predetermined level, the control unit constantly monitors the vibration generating unit while controlling the drive thereof to maintain the intensity below the predetermined level.

3. The condition improvement promoting device according to claim 1 or 2.

4. The scattering inducer is a thin-plate envelope containing fine particles of an ultrasonic scatterer having predetermined scattering properties scattered in a liquid, gel, or polymer medium.

3. The condition improvement promoting device according to claim 1 or 2.

5. the scattering inducer is a thin-plate envelope containing point-like scatterers made of bubbles scattered in a liquid medium; The control unit controls either or both of the arrangement and distribution state of the point scatterers in the scattering inducer unit to a desired state, thereby adjusting the scattering characteristics of the ultrasonic vibration and the low-frequency vibration.

3. The condition improvement promoting device according to claim 1 or 2.

6. the scattering inducer is a thin plate-like envelope filled with a magnetic fluid, The control unit controls either or both of the arrangement and distribution state of the ferromagnetic microparticles contained in the magnetic fluid in the scattering inducer unit to a desired state, thereby adjusting the scattering characteristics of the ultrasonic vibrations and the low-frequency vibrations.

3. The condition improvement promoting device according to claim 1 or 2.

7. The vibration energy of the ultrasonic vibration and the low-frequency vibration generated by the vibration generating unit has a vibration generation sound pressure of 0.1 to 1.5 MPa, and the irradiation time for one use on the subject is set to a maximum of 20 minutes. In the case of repeated use, the irradiation time is set to a maximum of 60 minutes in total per day with a 5-minute interval.

3. The condition improvement promoting device according to claim 1 or 2.

8. The vibration energy of the ultrasonic vibration and the low-frequency vibration generated by the vibration generating unit is scattered in all directions from the irradiation direction, and the ultrasonic and low-frequency vibration stimulates vascular cells, promoting the expression of eNOS, VEGF, and bFGF.

3. The condition improvement promoting device according to claim 1 or 2.

9. A method for promoting improvement of a condition of a subject for improving microcirculation in brain tissue and promoting improvement of dementia in the subject, comprising: a scattering inducing unit that induces scattering of the ultrasonic vibrations and the low-frequency vibrations is attached to a vibration generating unit that generates ultrasonic vibrations and low-frequency vibrations having a vibration frequency of 100 Hz or less at a contact portion that comes into contact with the outer surface of the head of the subject; driving and controlling the vibration generating unit so that vibration energy of the ultrasonic vibration and the low-frequency vibration is propagated throughout the target region in the brain of the subject; A method for promoting improvement of a condition.

10. In a state where the plurality of vibration generating units are arranged and worn around the head of the subject, the vibration generating units are driven and controlled so that a phase difference occurs between the ultrasonic vibration and the low-frequency vibration from each of the vibration generating units. The method for promoting improvement of a condition according to claim 9.

11. The ultrasonic vibrations and the low-frequency vibrations transmitted through the contact area with the external surface of the subject's head are received, and when the intensity of the vibration energy of the received ultrasonic vibrations and the low-frequency vibrations is equal to or greater than a predetermined level, the vibration generating unit is driven and controlled while constantly monitoring to maintain the intensity below the predetermined level. The method for promoting improvement of a condition according to claim 9 or 10.

12. The scattering inducer is a thin-plate envelope containing fine particles of an ultrasonic scatterer having predetermined scattering properties scattered in a liquid, gel, or polymer medium. The method for promoting improvement of a condition according to claim 9 or 10.

13. the scattering inducer is a thin-plate envelope containing point-like scatterers made of bubbles scattered in a liquid medium; The scattering characteristics of the ultrasonic vibration and the low-frequency vibration are adjusted by controlling the arrangement and / or distribution of the point scatterers in the scattering inducer to a desired state. The method for promoting improvement of a condition according to claim 9 or 10.

14. the scattering inducer is a thin plate-like envelope filled with a magnetic fluid, The scattering characteristics of the ultrasonic vibration and the low-frequency vibration are adjusted by controlling either or both of the arrangement and distribution state of the ferromagnetic fine particles contained in the magnetic fluid in the scattering inducement section to a desired state. The method for promoting improvement of a condition according to claim 9 or 10.

15. The vibration energy of the ultrasonic vibration and the low-frequency vibration generated by the vibration generating unit has a vibration generating sound pressure of 0.1 to 1.5 MPa, and the irradiation time for one use on the subject is set to a maximum of 20 minutes, and in the case of repeated use, the irradiation time is set to a maximum of 60 minutes in total per day with a 5-minute interval. The method for promoting improvement of a condition according to claim 9 or 10.

16. The vibration energy of the ultrasonic vibration and the low-frequency vibration generated by the vibration generating unit is scattered in all directions from the irradiation direction, and the ultrasonic and low-frequency vibration stimulates vascular cells, promoting the expression of eNOS, VEGF, bFGF, etc. The method for promoting improvement of a condition according to claim 9 or 10.

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