Automatic analysis device

The combined automatic analyzer efficiently mixes reagents for biochemical and immunoassay without enlarging the device by using a shared stirring unit, enhancing measurement reliability and reducing maintenance through controlled stirring.

JP2026036699APending Publication Date: 2026-03-06HITACHI HIGH TECH CORP +1
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Filing Date
2022-12-23
Publication Date
2026-03-06

AI Technical Summary

Technical Problem

Existing automatic analyzers face challenges in mixing reagents used for biochemical and immunoassay without increasing device size or cost, as most biochemical reagents are stirred manually and lack built-in stirring mechanisms, while immunoassay reagents require frequent stirring due to magnetic particles.

Method used

A combined automatic analyzer with separate analysis units for biochemical and immunoassay, incorporating a stirring unit that stirs reagents in the second analysis unit, controlled by a central unit to prevent device enlargement, and shares a mixing mechanism for both types of reagents.

Benefits of technology

Enables efficient mixing of reagents for different analysis principles without increasing device size, reducing maintenance workload, and improving measurement reliability by thorough stirring and bubble suppression.

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Abstract

A composite automatic analyzer capable of stirring a plurality of reagents used in a plurality of measurements based on different principles while suppressing an increase in size of the apparatus. [Solution] The system comprises a first analysis unit that performs analysis related to a first group of analysis items, a second analysis unit that performs analysis related to a second group of analysis items using a measurement principle different from that of the first analysis unit, a reagent storage unit that stores at least one first reagent container containing a reagent used in analysis by the first analysis unit and at least one second reagent container containing a reagent used in analysis by the second analysis unit, a stirring unit that stirs the solution in the second reagent container, and a control unit that controls the operation of the stirring unit, and the control unit controls the operation of the stirring unit to stir the solution in the first reagent container.
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Description

[Technical Field]

[0001] The present invention relates to an automatic analyzer. [Background technology]

[0002] Automated analyzers automatically perform the process from measuring the components to be measured to outputting the results by reacting blood, urine, or other biological samples (specimens) with analytical reagents that react specifically with the components to be measured in the samples and quantitatively detecting the complexes formed by this reaction.For example, in addition to biochemical analyzers and immunoanalyzers, there are also combined automatic analyzers that perform biochemical analysis and immunoanalysis in a single analyzer.

[0003] As a technique relating to a combined automatic analyzer, a technique has been disclosed that prevents a previous measurement sample from being carried over to the next measurement via an analysis unit (see Patent Document 1). [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Laid-Open No. 2012-53064 Summary of the Invention [Problem to be solved by the invention]

[0005] Some reagents used in biochemical analysis and immunoassay require stirring before use. For example, many reagents used in immunoassay contain magnetic particles, and immunoassay devices are equipped with a reagent stirring mechanism to frequently stir the reagents and prevent the magnetic particles from settling. However, most reagents used in biochemical analysis are stirred as needed before being placed in the device, and most devices do not have a stirring mechanism for stirring the reagents.

[0006] However, Patent Document 1 does not describe or suggest stirring of reagents used in biochemical analysis or immunoassay. For example, for measurements based on different principles such as biochemical analysis and immunoassay, it may be possible to provide a mechanism for stirring the reagents in each to take into account the impact of contamination with other reagents. However, this would result in an increase in the number of parts, which would increase the size of the device and costs, contrary to the demands of small hospitals and other facilities for space saving and cost reduction.

[0007] The present invention has been made in consideration of the above, and aims to provide a combined automatic analyzer that can mix multiple reagents used in multiple measurements based on different principles while preventing the device from becoming too large. [Means for solving the problem]

[0008] The present application includes multiple means for solving the above-mentioned problems, and one example thereof includes a first analysis unit that performs an analysis related to a first group of analysis items, a second analysis unit that performs an analysis related to a second group of analysis items using a measurement principle different from that of the first analysis unit, a reagent storage unit that stores at least one first reagent container containing a reagent to be used in the analysis by the first analysis unit and at least one second reagent container containing a reagent to be used in the analysis by the second analysis unit, a stirring unit that stirs the solution in the second reagent container, and a control unit that controls the operation of the stirring unit, wherein the control unit controls the operation of the stirring unit so as to stir the solution in the first reagent container. [Effects of the Invention]

[0009] According to the present invention, it is possible to mix a plurality of reagents used in a plurality of measurements based on different principles while suppressing an increase in the size of the device. [Brief explanation of the drawings]

[0010] [Figure 1] FIG. 1 is a diagram schematically illustrating the overall configuration of an automatic analyzer. [Figure 2] FIG. 2 is a functional block diagram illustrating the configuration of an analysis unit of the automatic analyzer. [Figure 3]FIG. 10 is a diagram showing the state in which the stirring rod has moved to the cleaning section. [Figure 4] FIG. 10 is a diagram showing the stirring rod moved to the reagent storage section. [Figure 5] FIG. 10 is a diagram showing how a reagent in a reagent container is stirred by a stirring rod. [Figure 6] FIG. 2 is a diagram illustrating the reagent storage unit together with related components. [Figure 7] 10 is a flowchart relating to the process of reagent registration and reagent mixing. [Figure 8] FIG. 4 is a diagram showing an example of reagent installation information recorded in a control unit. DETAILED DESCRIPTION OF THE INVENTION

[0011] Hereinafter, an embodiment of the present invention will be described with reference to the drawings. Note that, although the present embodiment will be described using an example of a combined automatic analyzer that performs biochemical analysis and immunoassay, the present invention can be applied to any combined automatic analyzer that performs multiple measurements based on different principles.

[0012] FIG. 1 is a diagram showing a schematic overall configuration of an automatic analyzer according to this embodiment.

[0013] In FIG. 1, the automatic analyzer 100 is roughly composed of a sample storage section 101, a reagent storage section 102, a reagent container 103, a reading section 104, a washing section 105, a stirring section 106, an analysis section 107, a control section 108, an input / output section 109, and a memory section 110.

[0014] A plurality of specimen containers for storing biological samples such as blood and urine are placed in the specimen storage unit 101. Although not shown, the specimen storage unit 101 may be, for example, a disk type in which a plurality of specimen containers are arranged and placed on a specimen disk that can rotate intermittently clockwise and counterclockwise, or a rack type in which specimen containers are held in a transportable rack and the rack is transported.

[0015] The reagent storage section 102 is a disk-type storage section in which multiple reagent containers 103 are arranged circumferentially on a reagent disk that can rotate intermittently clockwise and counterclockwise, and multiple reagent containers 103 corresponding to the analysis items of the automatic analyzer 100 are placed on it.

[0016] The reader 104 is a device that reads the reagent codes for identifying the reagent containers 103, and reads the reagent codes written in each of the multiple reagent containers 103 and transmits them to the controller 108 (see FIG. 6 and the like below).

[0017] The stirring unit 106 is a device that stirs the reagent filled in the reagent container 103 placed in the reagent storage unit 102, and stirs the reagent by inserting a stirring rod with a paddle at the tip into the reagent container 103 and rotating it (see Figures 3 to 5, etc., below).

[0018] The cleaning unit 105 is a device that cleans the stirring unit 106 with cleaning water after stirring the reagent in the reagent container 103, and cleans the stirring unit 106 by rotating the stirring rod and paddle in the stored cleaning water (see Figures 3 to 5, etc., described below).

[0019] The analysis unit 107 is a device that dispenses a sample and a reagent corresponding to an analysis item, and measures a predetermined component based on the reaction between them (see FIG. 2, etc., below).

[0020] The control unit 108 is a device that controls the overall operation of the automatic analyzer 100, and performs functions such as obtaining corresponding information from the memory unit 110 based on signals (reagent codes) transmitted from the reading unit 104, controlling the mechanical operation of each part of the automatic analyzer 100, and calculating the analysis data obtained by measurement.

[0021] The input / output unit 109 is a device for inputting operation commands by an operator and displaying analysis results, and is composed of, for example, a mouse, keyboard, touch panel, and liquid crystal display.

[0022] The storage unit 110 stores reagent information, analysis parameters, analysis item requests, analysis results, etc., and is configured, for example, by an internal / external memory such as a hard disk.

[0023] FIG. 2 is a functional block diagram showing the schematic configuration of the analysis unit of the automatic analyzer.

[0024] In FIG. 2, the analysis unit 107 has two analysis units with different measurement principles: a biochemical analysis unit 201 (first analysis unit) that analyzes biochemical items based on absorbance measurement, and an immune analysis unit 202 (second analysis unit) that analyzes immune items based on chemiluminescence (including electrochemiluminescence).

[0025] The biochemical analysis section 201 is composed of a biochemical dispensing section 203, a biochemical reaction section 204, a biochemical measurement section 205, and a biochemical washing section 221, and performs analysis using reagents related to biochemical items.

[0026] A plurality of reaction vessels for reacting samples with reagents are placed in the biochemical reaction unit 204. The biochemical reaction unit 204 is, for example, a disk-type device that can rotate intermittently clockwise and counterclockwise, and a plurality of reaction vessels are placed and aligned in the circumferential direction.

[0027] The biochemical dispensing unit 203 is an apparatus that accesses the specimen storage unit 101, the reagent storage unit 102, the biochemical reaction unit 204, and the biochemical washing unit 221 using an operating unit (not shown) to dispense specimens, reagents, etc. The biochemical dispensing unit 203 aspirates a predetermined amount of sample from a specimen container placed in the specimen storage unit 101, aspirates a predetermined amount of reagent for a biochemical item from a reagent container 103 in the reagent storage unit 102, and dispenses the sample and reagent into a reaction container placed in the biochemical reaction unit 204. The biochemical dispensing unit 203 may also have a function of stirring a reaction liquid, which is a mixture of a specimen and a reagent. Specifically, for example, the biochemical dispensing unit 203 may have a function of stirring the reaction liquid by a pipetting action that repeatedly aspirates and dispenses the reaction liquid, or a function of stirring the reaction liquid by applying a liquid flow to the reaction liquid using another mechanism such as a stirring rod or ultrasound.

[0028] The biochemical measurement unit 205 has a light source 223 and a spectrophotometer 224. The light source 223 irradiates light onto the reaction solution in the reaction vessel on the biochemical reaction unit 204. The spectrophotometer 224 calculates absorbance by measuring the luminous intensity of the light irradiated from the light source 223 and transmitted through the reaction solution at a wavelength set for each test item.

[0029] The biochemical washing unit 221 is a device that washes the biochemical dispensing unit 203 after dispensing of samples and reagents into reaction vessels has been completed. The biochemical washing unit 221 may also wash multiple reaction vessels after measurement by the spectrophotometer 224 has been completed.

[0030] The immune analysis section 202 is composed of an immune dispensing section 206, an immune reaction section 207, an immune measurement section 208, and an immune washing section 222, and performs analysis using reagents related to immune items.

[0031] A plurality of reaction vessels for reacting a sample with a reagent are placed in the immune reaction unit 207. The immune reaction unit 207 is, for example, a disk-type device that can rotate intermittently clockwise and counterclockwise, and a plurality of reaction vessels are placed and aligned in the circumferential direction. Although not particularly shown, a reaction unit having the functions of both the biochemical reaction unit 204 and the immune reaction unit 207 may be configured to be shared by the biochemical analysis unit 201 and the immune analysis unit 202.

[0032] The immunodispensing unit 206 is a device that accesses the specimen storage unit 101, the reagent storage unit 102, the immunoreaction unit 207, and the immunowashing unit 222 using an operating unit (not shown) to dispense specimens, reagents, and the like. The immunodispensing unit 206 aspirates a predetermined amount of specimen from a specimen container placed in the specimen storage unit 101, aspirates a predetermined amount of reagent for an immunological item from a reagent container 103 in the reagent storage unit 102, and dispenses the specimen and reagent into a reaction container placed in the immunoreaction unit 207. The immunodispensing unit 206 may also have a function of stirring a reaction liquid, which is a mixture of specimen and reagent. Specifically, for example, the immunodispensing unit 206 may have a function of stirring the reaction liquid by a pipetting operation that repeatedly aspirates and dispenses the reaction liquid, or a vortex mixing function that rotates the reaction container around its axis to generate a liquid flow such as a vortex in the reaction liquid and stir the reaction liquid.

[0033] The immunoassay unit 208 is composed of an aspiration nozzle 209, an immunocell 210, and a photomultiplier tube 211. The reagent for the immune item contains magnetic particles, and the magnetic particles in the reaction solution form a complex with the substance to be measured and the luminescent label through an antigen-antibody reaction. The immunoassay unit 208 quantitatively measures the substance to be measured by measuring the complex of the magnetic particles, the substance to be measured, and the luminescent label.

[0034] The suction nozzle 209 sucks the reaction liquid from the reaction vessel in the immune reaction section 207 and introduces it into the immune cell 210 .

[0035] A measurement electrode is provided inside the immunocell 210, and a complex of the substance to be measured, magnetic particles, and luminescent label in the reaction solution introduced into the immunocell is captured on the electrode by the magnetic force of a magnet (not shown). In the immunocell 210, a voltage is applied to the electrode, and the intensity of electrochemiluminescent light emitted by the luminescent label of the complex captured on the electrode is measured by a photomultiplier tube 211. Note that, although the present embodiment illustrates the use of electrochemiluminescence, other methods such as chemiluminescence, which uses a trigger reagent to induce a luminescent reaction, may also be used.

[0036] Figures 3 to 5 are diagrams that schematically show the structure of the stirring unit and the operation of stirring the reagent, with Figure 3 showing the stirring rod of the stirring unit moving to the cleaning unit, Figure 4 showing the stirring rod of the stirring unit moving to the reagent storage unit, and Figure 5 showing the stirring rod stirring the reagent in the reagent container.

[0037] As shown in FIGS. 3 to 5, the stirring unit 106 is generally composed of a stirring rod 301, a motor 302, an arm 304, and a vertical rotation operation unit 303.

[0038] Stirring rod 301 is attached below one end of arm 304, and a paddle 306 is attached to its lower end. The upper end of stirring rod 301 is connected to motor 302 attached to arm 304, and stirring rod 301 is rotated integrally with paddle 306 around its axis by motor 302. The other end of arm 304 is connected to vertical rotation unit 303.

[0039] The vertical rotation operating unit 303 has a two-axis movement mechanism for up and down (vertical direction) and rotation (horizontal direction), and the arm 304 can move up and down and rotate integrally with the stirring rod 301 by the vertical rotation operating unit 303.

[0040] The stirring unit 106 is disposed so that the reagent storage unit 102 and the washing unit 105 are located below the rotational path of the stirring rod 301 during the rotational movement of the arm 304. That is, the stirring rod 301 of the stirring unit 106 can be moved to a position directly above the washing unit 105 (washing tank) (see FIG. 3) and directly above the reagent container 103 placed in the reagent storage unit 102 (see FIG. 4) by the rotational movement of the arm 304 by the vertical rotational movement unit 303. Furthermore, the stirring rod 301 of the stirring unit 106 can be immersed at its lower end (paddle 306, etc.) in the washing water 311 of the washing unit 105 (not shown) and in the reagent 305 of the reagent container 103 (see FIG. 5) by the vertical movement of the arm 304 by the vertical rotational movement unit 303.

[0041] The reagent 305 is stirred by rotating the stirring rod 301 (paddle 306) while immersed in the reagent 305 in the reagent container 103. The structure related to stirring of the stirring unit 106 and the operation control by the control unit 108 are configured so that the magnetic particles in the reagent related to the immune analysis unit 202 are made more uniform by stirring.

[0042] Similarly, the stirring rod 301 is washed by rotating it while immersed in cleaning water 311 in the cleaning unit 105. The operation of the motor 302 of the stirring unit 106 and the vertical rotation unit 303 is controlled by the control unit 108. The cleaning water 311 used in the cleaning unit 105 is sent by a water supply pump 312 or the like through a liquid sending flow path connected to the cleaning tank of the cleaning unit 105, and is drained through a waste liquid flow path (not shown) connected to the cleaning tank of the cleaning unit 105.

[0043] Reagents containing magnetic particles for immune items need to be stirred thoroughly and frequently, as the magnetic particles may settle and aggregate at the bottom of the reagent container. When stirring the reagent, it is desirable to control the stirring rod 301 so that it is lowered to near the bottom of the reagent container 103 (for example, to a height of about 5 mm from the bottom of the reagent container 130) and the paddle 306 is rotated near the bottom of the reagent container 103 to stir the reagent. The reason why the lowered position of the stirring rod 301 is near the bottom of the reagent container 103 (about 5 mm from the bottom) is that the paddle 306 is lowered within a range where it does not come into contact with the bottom of the reagent container, and the paddle 306 is rotated near the bottom of the reagent container 103 to stir the magnetic particles that have settled to the bottom of the reagent container by the flow of liquid.

[0044] Similarly, when a reagent for a biochemical item contains latex particles, the latex particles that have settled to the bottom of the reagent container must be thoroughly mixed when the reagent is used for the first time, and in this embodiment, this is done using the stirring rod 301 of the stirring unit 106. Note that, since the latex particles contained in some biochemical items have a specific gravity that is significantly smaller than that of the magnetic particles in the immunological item, the stirring unit 106, which can stir the magnetic particles in the reagent for the immunological item, can be used to thoroughly stir the reagent containing latex particles for the biochemical item.

[0045] Here, reagent registration and reagent mixing, which are performed as analysis preparation operations before starting an analysis operation in the automatic analyzer 100 of this embodiment, will be described.

[0046] FIG. 6 is a diagram showing the reagent storage unit together with the related configuration.

[0047] Reagent registration is a process in which, when a user places a reagent container 103 in the reagent storage unit 102, the automatic analyzer 100 recognizes information linking the reagent information with the position of the placed reagent container 103 in the reagent storage unit 102. Note that the reagent information is stored in advance in the automatic analyzer 100 for each type of reagent prior to reagent registration.

[0048] 6, the reagent storage unit 102 has a total of eight reagent installation positions, P1 to P8, and the user can place up to eight reagent containers 103 in the reagent storage unit 102. In FIG. 6, the multiple reagent containers 103 placed in the reagent storage unit 102 are shown with a distinction between reagent containers 103a related to biochemical items and reagent containers 103b related to immunological items. The number of reagent containers 103 that can be placed in the reagent storage unit 102 is not limited to a maximum of eight, and the reagent storage unit 102 may be configured to be able to accommodate, for example, 36 reagent containers 103.

[0049] FIG. 7 is a flowchart showing the process of reagent registration and reagent mixing.

[0050] 7, when the user issues an instruction to start reagent registration via the input / output unit 109, the control unit 108 acquires the barcodes, two-dimensional codes, and reagent codes 401 recorded in identifiers such as RFID tags attached to each reagent container 103 via the reading unit 104 (step S100). Specifically, when the instruction to start reagent registration is input, the reagent storage unit 102 starts intermittent rotation, and as the reagent containers 103 (103a, 103b) in the reagent storage unit 102 pass in front of or stop in front of the reading unit 104, the reading unit 104 sequentially acquires the reagent codes 401 from the identifiers attached to the reagent bottles. The reagent codes 401 are numbers assigned to each type of reagent, and the reagent information is linked to the storage unit 110 of the device using the reagent codes 401 as key information.

[0051] When the reagent code 401 for one reagent container 103 is acquired, the control unit 108 subsequently acquires reagent information from the storage unit 110 using the acquired reagent code 401 as key information, and records the reagent installation information (step S110).

[0052] FIG. 8 is a diagram showing an example of reagent setting information recorded in the control unit.

[0053] As shown in Figure 8, the reagent installation information includes, in addition to a reagent code 401, information such as a reagent bottle icon 402, a reagent installation position 403, an analysis type 404, a reading history 405, whether mixing is required at initial installation 406, and whether or not the reagent is stirred 407, and is displayed on the input / output unit 109 as necessary.

[0054] The reagent bottle icon 402 is used to display reagent information on the input / output unit 109, etc., and is set corresponding to, for example, the analysis type 404. The analysis type 404 is set corresponding to the analysis item (immunology item, biochemistry item, etc.) of the reagent container 103. The read history 405 is information indicating whether the reagent code of the reagent container 103 placed in the reagent placement position has been read, and indicates whether there is history information indicating that the target reagent has been previously read by the automatic analyzer 100. The stirring necessity at initial placement 406 is information indicating whether the reagent filled in the reagent container 103 needs to be stirred at the initial placement. The reagent stirring / non-stirring 407 is information indicating whether the reagent filled in the reagent container 103 has been stirred. Note that in FIG. 8, the reagent placement information for a reagent placement position where no reagent container 103 has been placed, such as reagent placement position P7, is indicated by a symbol "-" indicating that no information is available.

[0055] Returning to FIG. 7, once the process of step S110 is completed, it is then determined whether or not the target reagent needs to be stirred based on the recorded reagent installation information (steps S120 to S140).

[0056] When determining whether the target reagent needs to be stirred, first, it is determined whether a reagent container is installed, i.e., whether a reagent container 103 is installed (step S120), and if the determination result is NO, i.e., if there is no target reagent container 103, it is determined that the reagent does not need to be stirred (step S121), and the determination is terminated.

[0057] Furthermore, if the determination result in step S120 is YES, it is then determined from the information on the analysis type 404 whether the reagent in the reagent container 103 is for analysis of an immune item or for analysis of a biochemical item (step S130).If the determination result is for analysis of a biochemical item (step S131), it is determined whether there is a reading history (step S132), and also whether mixing is necessary when performed for the first time (step S133).

[0058] If the determination results in steps S132 and S133 are both YES, that is, if there is no reading history and stirring is necessary at the time of the first implementation, the reagent in the reagent container 103 is determined to be a reagent to be stirred (step S140), and the determination of whether the target reagent needs to be stirred is completed.

[0059] If at least one of the determination results in steps S132 and S133 is NO, the reagent in the reagent container 103 is determined to be a reagent not to be stirred (step S121), and the determination of whether or not the target reagent needs to be stirred is completed.

[0060] If the result of the determination in step S130 is that the reagent is for immune analysis (step S134), the reagent in the reagent container 103 is determined to be a reagent to be stirred (step S140), and the determination of whether the target reagent needs to be stirred is completed.

[0061] Once the determination of whether the target reagent needs to be stirred (steps S120 to S140) is completed, it is then determined whether the determination of whether the target reagent needs to be stirred has been completed for all reagent containers 103 placed in the reagent storage section 102 (step S150).If the determination result is NO, the processing of steps S100 to S150 is repeated until the determination result becomes YES, i.e., until the determination of whether the target reagent needs to be stirred has been completed for all reagent containers 103.

[0062] If the determination result in step S150 is YES, the reagent in the reagent container 103 determined to be the reagent to be stirred is stirred (step S160), and the process of reagent registration and reagent stirring is completed.

[0063] The effects of the present embodiment configured as above will be described.

[0064] When a reagent for a biochemical item contains latex particles, the latex particles that have settled to the bottom of the reagent container 103 must be thoroughly mixed when the reagent containing latex particles is used for the first time (when there is no reading history). Conventionally, when using a reagent containing latex particles for a biochemical item, a user manually mixes the reagent by inverting the reagent container before registering the reagent, and then places the reagent in an automated analyzer for reagent registration and analysis. However, manual mixing by inversion can result in insufficient mixing due to differences in the number of times and speed of inversion among users. Furthermore, inversion can introduce air into the liquid, generating a large amount of bubbles in the reagent. Insufficient mixing and the generation of bubbles can lead to poor measurement results.

[0065] In this embodiment, the mixing unit that mixes the reagents in the immunoanalysis unit for immune items (analysis unit based on chemiluminescence, including electrochemiluminescence) is configured to mix the reagents in the biochemical analysis unit for biochemical items (analysis unit based on absorbance measurement). In other words, the mixing unit for reagents in the two analysis item groups, immune items and biochemical items, which have different measurement principles, is shared, eliminating the need to provide a mixing mechanism for each analysis item group, thereby simplifying the device configuration and reducing the device size.

[0066] Furthermore, since the specific gravity of the biochemical latex reagent is lower than that of the immune magnetic particles, by controlling the stirring of the biochemical latex reagent using the stirring rod that stirs the immune items, the reagent containing the latex particles related to the biochemical items can be sufficiently stirred.

[0067] Furthermore, since the system is configured to control the mixing of reagents related to immune items and reagents related to biochemical items in the same mixing unit, maintenance work such as cleaning the mixing unit and replacing consumables only needs to be performed on one mixing unit, which reduces the labor required for maintenance work compared to when mixing units related to immune items and biochemical items are provided separately.

[0068] Furthermore, by rotating the paddle 306 near the inner bottom of the reagent container to stir, it is possible to suppress the generation of bubbles due to stirring, thereby improving the reliability of the measurement results relating to the biochemical items.

[0069] Furthermore, since the system is configured to control the mixing of reagents related to immune items and reagents related to biochemical items in the same mixing unit, the user does not need to manually mix the latex particles related to the biochemical items by inverting them, which reduces the burden on the user and prevents the user from forgetting to mix by inverting them, thereby improving the reliability of the measurement results.

[0070] <Additional Notes> The present invention is not limited to the above-described embodiments, and includes various modifications and combinations within the scope of the gist thereof. Furthermore, the present invention is not limited to those including all of the configurations described in the above-described embodiments, and includes those in which some of the configurations are omitted. Furthermore, some or all of the above-described configurations, functions, etc. may be realized by designing, for example, an integrated circuit. Furthermore, the above-described configurations, functions, etc. may be realized by software, in which a processor interprets and executes a program that realizes each function. [Explanation of symbols]

[0071] 100...automatic analyzer, 101...specimen storage section, 102...reagent storage section, 103, 103a, 103b...reagent container, 104...reading section, 105...washing section, 106...stirring section, 107...analysis section, 108...control section, 109...input / output section, 110...memory section, 130...reagent container, 201...biochemical analysis section, 202...immunoanalysis section, 203...biochemical dispensing section, 204...biochemical reaction section, 205...biochemical measurement section, 206...immunodispensing section, 207...immunoreaction section, 208...immunoassay section, 209...suction nozzle, 210...immunocell , 211...Photomultiplier tube, 221...Biochemical washing section, 222...Immunochemical washing section, 223...Light source, 224...Spectrophotometer, 301...Stirring rod, 302...Motor, 303...Up and down rotation operation section, 304...Arm, 305...Reagent, 306...Paddle, 311...Washing water, 312...Water supply pump, 401...Reagent code, 402...Reagent bottle icon, 403...Reagent installation position, 404...Analysis type, 405...Reading history, 406...Necessity of stirring at first installation, 407...Whether or not to stir the reagent, P1 to P8...Reagent installation position

Claims

1. a first analysis unit that performs an analysis related to a first group of analysis items; a second analysis unit that performs an analysis of a second analysis item group using a measurement principle different from that of the first analysis unit; a reagent storage unit that stores at least one first reagent container containing a reagent to be used in the analysis by the first analysis unit and at least one second reagent container containing a reagent to be used in the analysis by the second analysis unit; a stirring unit that stirs the solution in the second reagent container; a control unit that controls the operation of the stirring unit, The automatic analyzer is characterized in that the control unit controls the operation of the stirring unit so as to stir the solution in the first reagent container.

2. 2. The automatic analyzer according to claim 1, An automatic analyzer characterized in that the solution in the first reagent container and the solution in the second reagent container are stirred in the same stirring unit.

3. 2. The automatic analyzer according to claim 1, the first group of analysis items is biochemical analysis items, The automatic analyzer is characterized in that the second group of analysis items is immunological analysis items.

4. 2. The automatic analyzer according to claim 1, the first analysis unit performs an analysis based on absorbance measurement; The second analysis unit performs analysis based on the principle of chemiluminescence.

Citation Information

Patent Citations

  • Automatic analyzer

    JP2012053064A