Apparatus, system, and method for promoting hair growth

Abstract

The present invention provides a device, system, and method for promoting hair growth by treating the adjacent skin tissue of a subject. [Solution] The method involves using a handpiece assembly to apply vacuum or suction along a target area on the skin surface of a subject for whom hair growth or hair stimulation is desired, and supplying at least one therapeutic material to the target area on the skin surface of the subject, wherein applying vacuum or suction promotes hair growth or stimulates hair growth.

Description

Technical Field

[0001] (Cross - Reference to Related Applications) This application claims the benefit of U.S. Provisional Patent Application No. 62 / 190,243, filed on Jul. 8, 2015 and U.S. Provisional Patent Application No. 62 / 320,476, filed on Apr. 9, 2016 . The entire contents of these applications are hereby incorporated by reference into this specification

[0002] U.S. Patent Application No. 12 / 346,582, filed on Dec. 30, 2008 and issued as U.S. Patent No. 8,343,1 16 on Jan. 1, 2013, U.S. Patent Application No. 11 / 392,348, filed on Mar. 29, 2006 and issued as U.S. Patent No. 8,048,089 on Nov. 1, 2011, U.S. Patent Application No. 12 / 83 2,663, filed on Jul. 8, 2010 and issued as U.S. Patent No. 8,814,836 on Aug. 26, 2014, and International Patent Application No. PCT / US2 014 / 024992, filed on Mar. 12, 2014 and published as International Publication No. WO2014 / 151104 on Sep. 25, 2014 are hereby incorporated by reference into this specification and form part of this specification

[0003]

Background Art

[0003] (Field of the Invention) This application generally relates to promoting hair growth, and more specifically, to devices, systems, and methods for promoting hair growth by treating adjacent skin tissue of a subject[[ID=4l]] This application is also applicable to any other type of skin treatment procedure, as well as other devices and systems for skin treatment

Summary of the Invention

[0004] According to some embodiments, it is positioned along the distal end of the handpiece assembly. An engaging member or shroud configured such that the engaging member is a handpiece assembly A proximal end configured to be attached to the proximal component of the bri, and the skin surface to be treated. The distal end is configured to contact and engage with the unevenness and other external features of the skin surface being treated. It comprises a body extending between a proximal end and a distal end, configured to conform to the shape, and this relationship The connecting member is flexible, and this engaging member conforms to the skin surface being treated during use. It is designed to facilitate the capture of existing liquids. [Means for solving the problem]

[0005] According to some embodiments, the engaging member or shroud is made of rubber or other elastomer. It includes a material (e.g., silicone rubber). In some embodiments, the engaging member is a therapeutic To facilitate the operation of the engaging member against the skin surface, at least one bellows or other It features foldable components.

[0006] In some embodiments, the engaging member or shroud is a component of the handpiece assembly. Configured to connect to the tip, the proximal end of the engaging member is fixed or removable to the tip. It is configured to be able to be coupled. In some embodiments, the engaging member or sh The loud is configured to be coupled to the main body portion of the handpiece assembly, and the engaging member The proximal end is fixedly or detachably coupled to the body portion of the handpiece assembly. It is structured in this way.

[0007] According to some embodiments, a method for promoting hair growth or hair stimulation in a subject is a hand The piece assembly is used to target areas on the skin surface of subjects where hair growth or hair stimulation is desired. Applying vacuum or suction along the minutes, and applying less to the target area on the skin surface of the subject. Both involve supplying a single treatment material and applying vacuum or suction, which promotes hair growth. It promotes or stimulates hair growth.

[0008] According to some embodiments, a method for promoting hair growth or hair stimulation in a subject is a hand The piece assembly is used to target areas on the skin surface of subjects where hair growth or hair stimulation is desired. Applying positive pressure along the minutes, and at least one of the target areas on the skin surface of the subject This includes supplying treatment materials and applying positive pressure to promote hair growth or stimulate hair growth. To encourage / promote.

[0009] According to some embodiments, vacuum or suction is applied continuously or intermittently. In some embodiments, vacuum or suction is applied intermittently using a pulse device. In one embodiment, the pulse device applies a first pressure and a second pressure along the skin surface of the subject. It is configured to generate them alternately, with the first pressure being greater than the second pressure, and the second pressure is a vacuum or suction. In some embodiments, the first pressure is a positive pressure. In this embodiment, the first pressure is a vacuum or suction.

[0010] According to some embodiments, the distal end of the handpiece assembly is located on the skin surface of the subject. It is configured to make contact with the handpiece assembly. In some embodiments, the handpiece assembly The distal end comprises a chip. In some embodiments, the chip is removable from the proximal portion of the handpiece assembly. In one embodiment, the chip comprises at least one suction port or opening to which vacuum or suction is selectively applied.

[0011] According to some embodiments, the at least one therapeutic material comprises one or more of the following materials: growth factors (e.g., human-derived growth factors, non-human-derived growth factors, liposome ( "courier") chemically altered growth factors, etc.), amino acids (e.g., leucine, isoleucine, valine, etc.), antioxidants, minoxidil, other antihypertensive vasodilators, finasteride, dutasteride, ketoconazole, spironolactone, flutamide, catechins, epicatechins, other phytochemicals, carnitine, rejuvaplex, copper peptides, other hair growth stimulants, other pharmaceuticals and non-pharmaceuticals, plant-derived products, cleansing shampoos or pre-cleansing shampoos, other cleansing solutions or pre-cleansing solutions (e.g., salicylic acid, GlySal ( [[ID=2|2]]trademark) (glycolic acid and salicylic acid mixture), other acids, etc.), and other natural and synthetic materials. In some embodiments, the at least one therapeutic material is contained in a bottle, and the bottle is in fluid communication with the handpiece assembly. In one embodiment, the at least one therapeutic material is contained in a cartridge, and the cartridge is configured to be fixed to the handpiece assembly. In some embodiments, the at least one therapeutic material is on the chip of the handpiece assembly ​​​​​​​​​​​​​ The treatment material is arranged such that at least one of the treatment materials is at least partially dissolved in the presence of a liquid. It is configured to release.

[0012] According to some embodiments, applying vacuum or suction to the skin surface of the subject It promotes increased blood flow to the target area or its vicinity. In some embodiments, the method is: The method further includes at least partially exfoliating the skin surface of the subject. Therefore, at least partially removing the surface of the subject's skin is necessary for the abrasive surface or abrasive material to be used. This includes using and peeling off. In one embodiment, the skin surface of the subject is peeled off at least partially. Detachment includes detachment using a chemical detachant. In some embodiments, At least partially peeling off the skin surface of the subject is the target of the skin surface of the subject. This is done before supplying at least one therapeutic material to the part. In some embodiments Therefore, at least one therapeutic material contains a growth factor.

[0013] According to some embodiments, the method further includes applying phototherapy to skin tissue. In some embodiments, phototherapy includes applying red or blue light to skin tissue. In one embodiment, phototherapy activates at least one therapeutic material to promote hair growth or It is used to stimulate hair.

[0014] According to some embodiments, the method involves at least partially penetrating the surface of the subject's skin. In addition, it includes penetrating the skin surface of the subject. Uses at least one needle assembly configured to selectively penetrate skin tissue. This includes, in some embodiments, at least one needle assembly is connected to the subject's skin. It is configured to have an internal passage that leads to the hair follicle of the subject or its vicinity. In some embodiments, at least one needle assembly is covered with one therapeutic material. It is either having or comprising at least one therapeutic material. In one embodiment, at One needle assembly comprises multiple hollow needles, and at least one treatment material is located in the passage of the hollow needle. It is configured to be transported by passing through it.

[0015] According to some embodiments, the method involves at least one deeper layer of the skin surface To facilitate the delivery of the treatment material, the targeted area on the subject's skin surface is massaged or vibrated. This further includes massaging or vibrating. In some embodiments, massaging or vibrating is less To facilitate the passage of at least one treatment material, at least partially along the surface of the subject's skin This results in opening the pores. In one embodiment, massaging or vibrating the skin Moving a handpiece with at least one nonlinear structure on a surface relative to the surface Includes. In some embodiments, at least one nonlinear structure is wavy but smooth. It has a surface or structure.

[0016] According to some embodiments, the method involves transplanting hair to or near the portion of skin tissue that has been transplanted. The method additionally includes administering treatment to the skin tissue to be treated. In some embodiments, the method includes administering treatment to the skin tissue. The procedure further includes transplanting at least several hair follicles to or near that area.

[0017] According to some embodiments, the method involves heating a target portion of the skin surface of the subject being treated. or additionally includes cooling. In some embodiments, the skin surface is heated or cooled. The alternative is to use a separate thermal control element (e.g., a thermoelectric element, a Peltier element, etc.). Includes.

[0018] According to some embodiments, the method enhances hair growth or hair stimulation in the subject This further includes supplying energy to a targeted area on the skin surface. In some embodiments, this includes supplying energy to a targeted area on the skin surface. The energy supplied to skin tissue is radio frequency (RF) energy, microwave energy. Includes one or more of the following: energy, ultrasonic energy, iontophoresis, and lasers. .

[0019] The above and other features, aspects and advantages of this application shall be described with reference to the drawings of specific embodiments. It should be noted that these are illustrative and not limiting to the present invention. These drawings are for illustrative purposes only. These are meant to illustrate the various concepts disclosed in the specification, and may not indicate scale. Please understand that. [Brief explanation of the drawing]

[0020] [Figure 1] This is a perspective view of a handpiece assembly configured for use with a skin treatment system, including one adapted to promote hair growth, according to one embodiment.

[0021] [Figure 2] This figure schematically shows a handpiece assembly that is in fluid communication with a fluid transport system or manifold system according to one embodiment.

[0022] [Figure 3A] This is a diagram of a system equipped with a pneumatic pulse unit according to one embodiment. [Figure 3B]This is another diagram of a system equipped with a pneumatic pulse unit according to one embodiment. [Figure 3C] This is another diagram of a system equipped with a pneumatic pulse unit according to one embodiment. [Figure 3D] This is another diagram of a system equipped with a pneumatic pulse unit according to one embodiment. [Figure 3E] This is another diagram of a system equipped with a pneumatic pulse unit according to one embodiment.

[0023] [Figure 4A] This is a diagram of a system comprising a pneumatic pulse section and a needle insertion section according to one embodiment. [Figure 4B] This is another diagram of a system comprising a pneumatic pulse section and a needle insertion section according to one embodiment. [Figure 4C] This is another diagram of a system comprising a pneumatic pulse section and a needle insertion section according to one embodiment. [Figure 4D] This is another diagram of a system comprising a pneumatic pulse section and a needle insertion section according to one embodiment. [Figure 4E] This is another diagram of a system comprising a pneumatic pulse section and a needle insertion section according to one embodiment.

[0024] [Figure 5] This is a side view of a handpiece assembly having an engaging member or shroud along the distal end of the handpiece assembly.

[0025] [Figure 6] This figure shows an embodiment of Figure 5 during a skin treatment procedure, viewed from a certain orientation. [Figure 7] This figure shows the embodiment of Figure 5 during a skin treatment procedure from a different orientation.

[0026] [Figure 8] This is a front perspective view of the engaging member and tip.

[0027] [Figure 9]This is a front perspective view of another embodiment of an engaging member or shroud positioned along the distal end of a handpiece assembly.

[0028] [Figure 10A] This figure shows one embodiment of a light stick device configured for use in conjunction with hair growth and / or other skin treatment systems. [Figure 10B] This figure shows another embodiment of a light stick device configured for use in conjunction with hair growth and / or other skin treatment systems.

[0029] [Figure 11A] This figure shows a station for a thermal control system according to one embodiment. [Figure 11B] This figure shows a station for a thermal control system according to one embodiment.

[0030] [Figure 12A] This is a diagram of an assembly equipped with a rollerball for use with a treatment system, according to one embodiment. [Figure 12B] Another diagram of an assembly with a rollerball for use with a treatment system, according to one embodiment.

[0031] [Figure 13] This is a perspective view of an assembly equipped with a core member for use with a treatment system, according to one embodiment.

[0032] [Figure 14] This figure schematically shows a side view of an assembly equipped with a core member for use with a treatment system, according to one embodiment.

[0033] [Figure 15] This figure schematically shows a side view of an assembly comprising a core member and a rollerball for use with a treatment system, according to one embodiment. [Modes for carrying out the invention]

[0034] Various embodiments of the apparatus, systems, and methods disclosed herein are for promoting hair growth and Treatment devices, treatment systems and treatments for skin conditioning / treatment related to hair growth. While the method may have a specific relevance, the features, advantages, and other characteristics disclosed herein are, for example, medical devices and medical procedures, machinery and devices not for skin treatment, and methods, etc. It may also be applied directly or indirectly in other uses.

[0035] According to some embodiments, the apparatus, system, and method promote hair growth It can be used for purposes such as stimulating hair follicle growth and / or promoting hair growth. To do so, in the scalp and / or within the scalp (for example, at least partially within the subject's skin tissue) ) can selectively transport one or more fluids and / or other substances. As will be explained in more detail, the skin surface of the subject (e.g., scalp) and / or skin surface The transport of such materials into the interior is characterized by or involves the force of one or more injections or intrusions. It can be borrowed and facilitated. For example, requested or needed treatment materials (e.g., growth factors) The transport of ) can be facilitated by one or more of the following uses: (e.g., blood flow Use of suction or vacuum (to stimulate), force, pressure and / or mechanical vibration (For example, mechanical pulse application using air transport to the target skin surface), needles or other tissue Use of devices or instruments for penetration, use of peeling or massage of target skin tissue, target skin The use of tissue thermal control (e.g., heating or cooling), and energy used simultaneously with the delivery of therapeutic materials. - Conveying (e.g., ultrasound, laser, radio frequency energy, microwave energy, electric) Use of current or electrical stimulation, iontophoresis, etc., light (e.g., red light, ultraviolet light, etc.) Use, hair transplantation, or other hair growth systems, methods, and / or techniques, etc.

[0036] The various processes, techniques, and / or other features described herein are intended to achieve specific results. To achieve this, for example, by promoting hair growth in the subject or strengthening the subject's existing or new hair. They can be used individually or in conjunction with each other for this purpose. Conveying therapeutic fluids and / or other materials

[0037] In some embodiments, growth occurs in a target area of ​​the subject's skin (e.g., the subject's scalp). To promote hair growth, the skin tissue of the subject, preferably (at least partially) within the skin tissue. It can transport one or more therapeutic fluids and / or other materials. For example, several This configuration allows for the delivery of growth factors to the skin surface of the subject. Growth factors, in particular, , human-derived growth factors (e.g., FGF9 and other fibroblast growth factors (FGF), human Fibroblast-conditioned medium and other fibroblast growth factors, epidermal growth factor (EGF)-related ligans D, Transforming Growth Factor β (TGF-beta), Insulin-like Growth Factor ( IGF), hepatocyte growth factor / dispersion factor (HGF / SF), and platelet-derived growth factor ( PDGF, etc., synthetic growth factors, liposomes (guide("courier")) chemically This includes modified growth factors, other human-derived growth factors and / or non-human-derived growth factors, etc. It is possible. In some embodiments, growth is delivered to the skin tissue of the subject for the purpose of promoting hair growth. The factors are not limited to, but include human growth factors, synthetic growth factors, or laboratory-derived growth factors. Includes factors, etc. In other embodiments, in addition to or instead of growth factors, one or more Other substances can be delivered to the subject's skin. For example, in some embodiments, To promote hair growth, apply one or more of the following to the target area or part of the subject's skin. It can transport: growth factors, amino acids (e.g., leucine, isoleucine, variol). (etc.), antioxidants, minoxidil, other antihypertensive vasodilators, finasteride, dutasteride Steride, ketoconazole, spironolactone, flutamide, catechin, epicatechin , other phytochemicals, carnitine, Rejuvaplex, copper peptides Other hair growth stimulants, other pharmaceuticals and non-pharmaceuticals, plant-derived products, cleansing shampoos Alternatively, a pre-cleansing shampoo, other cleansing solutions, or pre-cleansing solutions. (For example, salicylic acid, glycal ("GlySal") (trademark), glycolic acid and salicylic acid Acid mixtures, other acids, etc., as well as other natural and synthetic materials, etc.

[0038] According to some embodiments, the exact one or more materials or substances used are Regardless of the combination thereof, the transport of drugs and / or other substances and materials. This can favorably assist hair growth along the target skin surface of the subject. In this embodiment, the transport of such fluids and / or other materials is performed as desired or required. This can promote the improvement of the health of natural hair and / or transplanted hair.

[0039] As an example, fluids and / or other materials are illustrated herein with reference to Figures 5 to 9. Using a handpiece assembly identical or similar to the one described above, on the skin of the subject ( For example, it can be delivered to a target area (such as the scalp of the subject). In other embodiments, other subjects Using a device (e.g., a handpiece assembly) or method, one or more fluids It can be delivered to the target skin of the subject. In some configurations, for example, see the figure in this specification. A handpiece similar to or identical to the one shown in 1 can be used.

[0040] Figure 1 shows handpiece assembly 1 configured for use with a skin treatment system. One embodiment of 00 is shown. As shown in Figure 1, the handpiece assembly 100 is the handpiece assembly The piece assembly 100 is configured to receive the tip 130 along its distal end 120. It may include a main body portion 110. In some embodiments, the chip 130 is It is detachably attached to the distal end of body portion 110. However, alternatively, as requested Alternatively, if necessary, the chip can be permanently attached to the main body 110. When moving the handpiece assembly 100 against the subject's skin, the device selectively targets the skin. It may include one or more polishing features, polished surfaces, etc., configured to polish. The tip can be configured to perform micro-skin polishing on the target skin surface. Regarding the selection of chips that may be incorporated into any of the embodiments disclosed herein Further details are available in the U.S. Patent Application filed on March 29, 2006, and granted on November 1, 2011. Described in U.S. Patent Application No. 11 / 392,348, issued as No. 8,048,089 It has been incorporated herein by reference in its entirety and forms part of this application.

[0041] Continuing to refer to Figure 1, the handpiece assembly 100 has one or more vials Alternatively, it can be made to be the size and shape that can accept cartridge 200, or , it can be configured in that way. For example, as shown in the figure, the handpiece assembly is , including recesses or other openings in which vial 200 can be placed and secured. Yes, it is possible. Such vials or other containers 200 can be used to promote hair growth, during use, It comprises one or more fluids and / or other materials that can be selectively delivered to the surface of the elephant's skin. It is possible.

[0042] In some embodiments, one or more materials are used in the tips or other parts of a skin treatment system. Strategically embedding, impregnating, positioning, and storing on one or more surfaces or areas of a part or component. It can be and / or deployed. Such materials include solids, semi-solids, other dry substances, and gels. It may include concentrated solutions, etc. For example, such materials may include foam pads or other Tablets, capsules, pills, discs, or other dissolvable materials immersed in a sponge-like material, etc. As a solid, in loose form (for example, on a chip, in a recess of a chip or in other parts), This can be done by placing it inside a cartridge or other container, or by adhering it to one or more surfaces. (and) can be supplied. Therefore, in certain configurations, the water delivered to the chip (for example) (Distilled water, tap water, filtered water, etc.), physiological saline, other diluents and / or other fluids are used. Skin treatment systems (e.g., handpiece assemblies, upstream flow of handpiece assemblies) On the tip of the body line, etc., inside the cartridge or other container, and / or other parts Alternatively, materials embedded, impregnated, and / or placed on or within the constituent elements may be selected. It can be selectively dissolved, liquefied, melted, softened, diluted, or prepared. Therefore, as desired or If necessary, any desired hair growth material or hair growth preparation is applied favorably to the skin surface being treated. It can be supplied.

[0043] Furthermore, as shown in Figure 1, the handpiece assembly 100 can be connected to a vacuum. For example, the waste conduit 180 of the handpiece assembly is for exfoliated skin, used To remove the fluid, waste, and / or other substances from the treatment surface, use suction or direct sunlight. It can be arranged to communicate with an air source (not shown) and fluid. As mentioned above, handpipe - Assembly 100 is configured to accept one or more removable chips 130. The chip can perform specific procedures, desired results and / or other considerations. The following may be selected based on the item. The distal portion 120 of the handpiece assembly 100 is the main body To prevent undesirable leakage between part 110 and tip 130, one or more O-rings are used. It may include a 138 or other sealing member. Further details regarding the removable tip are available. Further details are available in the U.S. Patent Application No. 201, filed on July 8, 2010, and published on April 7, 2011. U.S. Patent Application No. 12 / 832,663, published as No. 1 / 0082415, states It is included and incorporated herein by reference in its entirety (this is an example and not an limitation). (There is no such thing, but see Figures 5B and 8A-16B of the referenced application.)

[0044] Continuing to refer to Figure 1, the handpiece assembly 100 contains one or more vials Alternatively, it can be configured to accept cartridge 200. For example, vial 200 refers to standard or non-standard vials, ampoules, or other arbitrary vials, without limitation. It may include a container. In some embodiments, it is included in the cartridge 200. Hair growth products and / or any other therapeutic fluids or therapeutic materials may come into contact with one or more sources of aspiration (e.g., Then, using a vacuum source configured to remove waste from the chip, the chip 130 It can be directed towards and attracted. In other embodiments, the fluid contained in the cartridge and The material and / or other materials will flow naturally towards the tip 130 or through a fluid transfer device. It is transported with assistance. Cartridge 200 contains the desired volume or other amount of serum or When other materials are transported to the tip 130, selectively from the handpiece assembly 100 It can be removed.

[0045] In some embodiments, a vacuum is in fluid communication with the waste conduit 180 from the tip 130. To remove waste, and from vial or cartridge 200 to tip 130 To be configured to facilitate the transport of serum, other fluids and / or any other material to This can be done. When tip 130 is placed against the subject's skin, the handpiece assembly Suction generated by a vacuum source is supplied to one or more of 100 fluid channels or fluid conduits. It can be reached. Generated within the corresponding channel or conduit of the handpiece assembly. Such suction force is maintained or substantially maintained by the tip 130 against the subject's skin. As long as it is maintained, it can be kept as is. As a result, one or more flows of assembly 100 The suction force generated by the vacuum source can be transferred to the body transport channel, thereby Transferring fluids and / or other materials from vials or other containers to tip 130. It is possible.

[0046] In some embodiments, serum, other fluids and / or other materials are present in one or more peripheral areas. or other off-center channels, conduits and / or other lines or accessories It can be transported to the chip 130 through (for example, from a cartridge, external power source, etc.). For example, in the handpiece assembly 100 shown in Figure 1, such fluids and / or Other materials may be used for one or more internal channels and / or chip waste guides in the assembly. It can be delivered through a tube. Therefore, in some embodiments, one or more channels The connector and / or other hydraulic components are located on the handpiece assembly 100. The conveying opening, located off-center of the chip, is properly positioned to communicate with the conveying line and fluid. The sea urchin may need to be restructured.

[0047] According to a particular embodiment, as shown in Figure 2, a vial, cartridge or other container 200 is a manifold that may have multiple individual fluid conduits 410, 420, 430, 440. They are positioned to communicate fluidly with the system 400. Next, these fluid conduits 410, 4 One or more of 20, 430, and 440 are in fluid communication with a separate container (not shown). Yes, it is possible. For example, in some embodiments, such fluid conduits are used in tower systems. It can communicate with a vessel (see, for example, Figures 9 to 11) and fluids. In the illustrated embodiment, Each of the fluid lines 410, 420, 430, and 440 is in fluid communication with the main fluid conduit 450. The main fluid conduit 450 is fixed within the handpiece assembly 100, or It connects to the nozzle 202 along the proximal end of another container 200. One or more of the fluid conduits This selectively regulates the transfer of fluids and / or other materials to the handpiece assembly. Therefore, valves 412, 422, 432, 442 or other flow control devices or flow control devices It can be equipped with the mechanism. In the illustrated configuration, the manifold system 400 has a total of four It is equipped with fluid branches. However, the system may be required or necessary depending on the specific application or use. Depending on the need, more or fewer fluid branches (e.g., 1, 2, 3, 4, 5, 6) It can have 7, 8, and 9 or more, etc.

[0048] According to a particular embodiment, the fluid line or fluid guide of the manifold system shown in Figure 2 One or more of the tubes contain serum, a fluid and material adapted to promote hair growth. It is configured to supply other therapeutic fluids, etc. However, alternatively, among the conduits, One or more of these are water (e.g., distilled water, tap water, filtered water) supplied to the handpiece assembly 100. It is configured to accept physiological saline, other diluents or dissolving solutions, other fluids, etc. This is possible. As will be described in more detail herein, such fluids can be used in a handpiece. Distributed on, on, within, or within various surfaces of assembly 100 (e.g., a chip). When placed in contact with one or more solids, gels and / or other materials, it dissolves, dilutes, liquefies, It can be adapted to soften and / or mix with one or more materials. Such material may be applied to the interface between the skin and the tip or to any other location where requested or required. We can provide a convenient method for supplying materials. suction / vacuum

[0049] In some configurations, one or more therapeutic materials are delivered, injected, diffused, and / or placed on the skin surface. or accelerates progression, stimulates blood flow along or near the target skin surface, and / or or in order to provide one or more other benefits or advantages, the target skin surface (for example, the subject's Vacuum, suction, or negative pressure can be applied to the scalp. Such vacuum can engage with the skin. And it is applied using a handpiece specifically designed to supply such vacuum force. For example, an embodiment identical or similar to those disclosed in any of the following applications. The following handpiece can be used: Filed on December 30, 2008, and in 2013 U.S. Patent Application No. 12 / 3, issued on January 1, 2018 as U.S. Patent No. 8,343,116 Patent No. 46,582, filed on March 29, 2006, and granted in the United States on November 1, 2011. U.S. Patent Application No. 11 / 392,348, 201, issued as No. 8,048,089 Filing on July 8, 2000, and granted U.S. Patent No. 8,814,836 on August 26, 2014. U.S. Patent Application No. 12 / 832,663, issued on March 12, 2014, and It was requested and published on September 25, 2014, under the international publication number WO2014 / 151104. International patent application PCT / US2014 / 024992 has been opened. As described herein... Therefore, all of the aforementioned applications are incorporated herein by reference. The embodiments described in the specification involve one or more containers (e.g., a tower system or manifold). Fluids and other treatments from vials or bottles (included in the lud system) to the skin interface This provides an exemplary system that utilizes vacuum to assist in material transport.

[0050] By using such handpieces and / or other devices or systems and provide one or more benefits or advantages during treatment (e.g., hair growth promotion or hair growth strengthening). This can be done by, for example, delivering suction or vacuum to the target skin surface. Skin surface (e.g., the target hair growth area, its vicinity, or adjacent superficial or surface layer) It can promote blood flow to the tissues and / or deep tissues. In certain situations This helps create an environment that provides therapeutic benefits to the target tissue and improves the prospects for hair growth. Furthermore, by using vacuum or suction, deeper areas of the target skin tissue can be reached. Fluids and / or other materials (e.g., growth factors, amino acids, antioxidants, minoxidil) to the fluid and / or other materials. Transport of (Jill, other antihypertensive vasodilators, other hair growth stimulants, other natural or synthetic materials, etc.) This can further improve delivery. Vacuum and the pressure used, as well as pulse and positive pressure

[0051] In some embodiments, the injection or transfer of fluid into the target skin tissue is performed on the tissue surface. Pressure conveying (e.g., application of continuous or intermittent force) and / or mechanical pulses It can be improved by utilizing the given. For example, the handpiece assembly and / or Other devices or systems are used to deliver pulsed air to the target skin tissue of the subject. It can be used. In some embodiments, pressure, pulse and / or similar techniques By using this, the delivery of therapeutic fluids and / or substances to deeper layers of skin tissue is enhanced. It can help and facilitate treatment procedures (e.g., hair growth promotion protocols or methods). In such a configuration, mechanical force (for example, pressure, pulse, etc.) is used. Therefore, it is transported to the tip of the handpiece or other device or system, or to the vicinity thereof. It helps the therapeutic fluid and / or other substances to be pushed or driven deeper into the skin tissue. It can be extended. In some embodiments, less of the therapeutic fluid and / or other material However, the ability to transport some of it to deeper layers of skin tissue facilitates the entire process, and such tissue It can promote health and hair growth in the area.

[0052] According to some configurations, it can transport air at a desired pulse rate or pulse frequency. The device or system configured to deliver the therapeutic fluid and / or to deeper layers of the target skin surface It can also be used to facilitate the "driving" of other substances. (e.g., air) Further details regarding the use of pulses based on the above were filed on March 12, 2014, and 20 International Publication Number WO2014 / 151104 was published on September 25, 2014. This is described in patent application PCT / US2014 / 024992, the entirety of which is included in this specification. It will be incorporated into the book.

[0053] Figures 3A to 4E show the combination of air transport (e.g., pulse application) and / or puncture. In addition, one or more fluids and / or other therapeutic materials (e.g., hair growth stimulants) are applied to the skin interface. The following are not limited embodiments of a handpiece assembly configured to supply a load.

[0054] According to some embodiments, as described herein, a therapeutic procedure (e.g., hair growth treatment) may be performed. The effectiveness of intensive treatment is enhanced by delivering mechanical vibrations to the skin surface being treated. This is possible. For example, air or other fluids can be used for the transport of peeling and / or treatment fluids. At times, pulses can be selectively applied or delivered to the skin surface. In other embodiments, Instead of, or in addition to, fluid transport, other forms of mechanical energy (e.g., acoustics) Energy, needle penetration, etc. can be used. This can be done upon request or as needed. It can be performed simultaneously with and / or before / after skin treatment procedures. As described above, in some embodiments, air or other fluid is supplied to the skin surface to be treated. It can be beneficial to do so. Air helps to achieve certain effects on the skin surface. in which specific flow rate, pressure, intensity, pulse rate or pulse frequency and / or duration It can be transported between, for example, during, before, and / or during the procedure of micro-skin polishing. Later, air or other fluids are pulsed onto the skin, and less of the subject's skin tissue is absorbed after peeling. To facilitate and smooth the transfer of partial serum, other fluids and / or other substances. This is possible. In some embodiments, the air pressure pulses (for example, continuously carry a continuous stream of air) It may include a square wave pulse (such as one that does not carry air, and there is no stage where air is not transported).

[0055] In some embodiments, air is transported through air transport passages in individual injection units. Depending on the volume, strength, pressure and / or other characteristics of the injection part, such an injection part This can facilitate the application of intermittent force along the subject's skin. As mentioned above. Such mechanical or pneumatic vibrations to the skin can offer one or more benefits. Yes, it is possible. For example, force or pressure applied to the skin (for example, through a fluid transport passage) ) Serum, fluids, and / or other substances being transported to deeper layers of skin tissue via the chip. It can facilitate the drive. The repetitive vibrations generated by the air injection unit are therapeutic. It loosens dirt, oil, and / or other undesirable substances from pores along the skin surface. This can also be encouraged.

[0056] Handpiece assembly configured to deliver air or other gases during skin treatment procedures A buri is a method by which air is conveyed through one or more air conveying passages, and / or suction passages. The amount of negative pressure applied by the vacuum source through the path (or, for example, realized along the chip) The amount of negative pressure can be configured to be adjustable by the user. In some embodiments The negative pressure within the suction passage prevents contact between the subject's skin and the surrounding lip and internal lip during use. It is high enough to maintain the skin surface (for example, the scalp of a person for whom hair growth is desired). While other skin areas are being peeled or treated, the treatment fluid is kept stable and constant on the work surface. This can help maintain the flow. A sufficiently high vacuum along the tip (for example, (At the spray nozzle) While air is being delivered to the skin surface, the lip does not lose contact with the skin surface. This can encourage that behavior.

[0057] According to some embodiments, before performing a micro-skin polishing procedure or other skin treatment procedure, During or after placement, vibrate and / or penetrate a specific area or part of the subject's skin. To do this, one or more needles or other puncture devices can be used. The component can be inserted into and removed from the adjacent skin tissue for a certain period of time. As a result, At least temporarily, it is possible to form multiple small-diameter passages within the target skin tissue. Serum, other therapeutic agents and / or other substances delivered or applied to the skin via such passages. This allows for more favorable delivery of the substance to deeper layers of the skin tissue.

[0058] Figures 3A to 3E show the main body 3210 and the tip 324 positioned along the distal end of the main body. Various figures of different embodiments of the skin treatment device 3200, which comprises 0, are shown. In this configuration, the chip 3240 can be detachably fixed to the main body 3210. Figure 2 As shown in the front view 2B, the tip 3240 is suitable for the device 3200 to be applied to the subject's skin. When positioned, the outer part is configured to come into contact with the skin surface (e.g., the subject's scalp). The side or peripheral lip 3260 may be provided. The tip 3240 may also have, for example, (Simultaneously with treatment of the outer lip or ridge or peripheral lip or ridge 3260) It further comprises an inner lip or ridge 3252 configured to come into contact with the skin surface. It is possible to obtain it.

[0059] Continuing to refer to Figure 3B, we see the outer lip or ridge 3260 and the inner lip or ridge The substantially annular region defined between the edge 3252 has one or more openings or ports. It is possible to obtain, for example, as shown in the figure, the annular region has one or more vacuum or suction ports. Port 3242 may be provided. In some embodiments, such port 3242 It comprises a post or other member extending above the bottom surface of the annular region, as shown in Figure 3B. The vacuum or suction port 3241 is adjacent to or near the inner ridge 3252. (For example, it can be strategically positioned in the immediate vicinity.) With this configuration, device 3 During use of 200, the relationship between the lip or ridge 3260, 3252 and the skin surface of the subject It can help maintain contact. It helps to maintain consistent and sufficient contact between the tip and the subject's skin. The ability to hold air or other fluids through the central opening 3256 of the tip during use There can be difficulties when applying pulses. As you can see, the positive air pressure during pulse application The transport process involves preventing contact between the tip (e.g., particularly the inner lip 3252 and surrounding structure) and the skin. There may be attempts to cause loss. Therefore, the system ensures proper skin contact during use of the device. To ensure contact is maintained, along, near, or there of the pulse port 3256. It can be configured to provide sufficient suction or vacuum adjacent to it. In other configurations, The suction port or opening 3242 is coplanar with the bottom surface of the annular region of the tip, or They may be nearly coplanar and / or recessed. Furthermore, the port or opening 3 The shape, size, orientation, spacing, position, quantity and / or other characteristics of the 242 can be specified or If necessary, it can be changed from what is shown in Figure 3B.

[0060] As shown in Figure 3B, the boundary between the two lips or ridges 3260, 3252 The annular region has one or more fluid transport ports 3246 and / or additional vacuum or suction ports It may also include part 3248. In one embodiment, as shown in Figure 3B, a single fluid carrier The delivery port 3246 is located almost opposite the vacuum or suction port 3248, and the skin being treated To facilitate the delivery of the therapeutic fluid over a wider surface area of ​​the skin. In other embodiments, the fluid delivery port Quantity, orientation, position, size, shape and / or additional suction ports for T and / or additional suction ports. Other minor details can be changed.

[0061] Continuing to refer to Figure 3B, the region defined inside the inner lip 3252 is the device 3 The 200 includes one or more passages extending through its interior and an opening 3256 that is in fluid communication with them. As detailed in the specification, such openings 3256 allow pulsed air to enter the skin during the treatment procedure. It can be used to selectively supply gas or other fluids.

[0062] As shown in Figures 3B and 3C, the pulse aperture 3256 of the chip is (for example, one (Through the above internal lumens, internal conduits or other internal passages) the distal portion of the device 3200 Alternatively, it can be positioned to communicate with the pulse fluid connector 3204 towards the rear. Yes. Such connector 3204 is connected directly or indirectly to a pulsed air source. Selectively air bubbles are created on the tip and skin surface at the desired frequency, duty cycle, volume, etc. It can transport air. As mentioned above, such pulsed air or other fluids By transporting the fluid, it is possible to help the therapeutic fluid penetrate deeper into the skin surface. This can improve skin treatment procedures (for example, hair growth treatments). For example, In some embodiments, mechanical vibrations caused by the application of air pulses are delivered to the skin surface. The therapeutic fluid can be driven, pushed, or advanced into deeper layers of the skin. .

[0063] According to some embodiments, the application of pulses to air or gas in the device 3200 relates to One or more of these parameters can be adjusted by the user as needed or requested. For example, in some embodiments, high-pressure and low-pressure levels in a pulse sequence This can be changed. As mentioned above, the low pressure level is (for example, relative to atmospheric pressure) It can be zero, positive pressure or above zero, or negative pressure or below zero. In some embodiments, the air undergoes positive and negative pressure (for example, suction) during a specific cycle. A pulse is applied between the high and low pressure levels. In other embodiments, both high and low pressure levels are at atmospheric pressure. It can be made higher than the pressure. Therefore, the pulse period must include a vacuum phase or an aspiration phase. There is none. In other embodiments, the low-voltage level is zero or near zero. The options include pulsed injection into the skin interface (for example, to improve serum penetration into the target skin surface). Any practical applications disclosed herein that are configured or configurable for use in pneumatic conveying. It can be applied to various construction methods.

[0064] Although not shown in the embodiments of Figures 3A to 3E, it is possible to pulse air along the skin interface. The chip 3240, which is configured as follows, has one or more abrasive members (e.g., posts, helices, ridges). It can be further equipped with brushes, sharp edges, rough surfaces, etc. Therefore, several implementations In this configuration, while the device 3200 is operating (for example, during the transport of pulsed air and / or (While maintaining suction via the corresponding vacuum port), the user applies the device to the target skin surface. By selectively translating or moving the tip, the skin (e.g., scalp, other skin where hair growth is desired) is targeted. It can polish and / or treat areas of the skin, etc., at least partially.

[0065] However, in other embodiments, the device 3200 delivers serum and / or more serum to deeper layers of the skin. It is equipped with a non-polished tip 3240 for the purpose of driving other fluids. This is requested or required Depending on the treatment process or protocol, preliminary and intermediate (e.g., secondary) steps Alternatively, it can be implemented as part of a subsequent (e.g., tertiary) process. For example, several In this embodiment, such a non-abrasive apparatus follows a polishing or preliminary treatment, process, or stage. It is used (and the corresponding method is used).

[0066] Continuing to refer to Figures 3A-3E, device 3200 is one of the components included in cartridge C. The above configuration is configured to be in fluid communication with serum and / or other therapeutic fluids. Yes, it is possible. As shown in the diagram, such a cartridge is compatible with the handheld device 3200. It can be fixed within the recess, and in the illustrated configuration, it is positioned along the distal end of the device. In other embodiments, the device may be positioned along the distal end of the device (or any other part of the device). (Along the way) it may include ports. Such ports (not shown in the example configuration) are primary It can be arranged to communicate with a fluid transport line. In some embodiments, For example, such a main fluid transport line or conduit is disclosed herein with reference to Figure 2. Configured to transport serum and / or other fluids from a manifold system such as It is possible.

[0067] As shown in Figure 3C, the handheld 3200 is a vacuum source and / or pulsed air source. It may include additional ports 3202, 3204 for connecting to such fluids. The source can be separated from the treatment system, or, if desired or necessary, the system It may be incorporated at least partially into the . In some embodiments, a vacuum source and pulse The air source allows the user of the device to control the suction level and / or pulse level during use to their advantage. To allow for adjustment, the control module and other controllers and data are kept to a minimum. To communicate.

[0068] According to some embodiments, the concept of pulsed air is used to selectively penetrate the skin. It can be combined with the configured movable needle assembly. Needle entry section and pulsed air transport. The combined system delivers serum and / or other substances to the skin surface being treated. This can provide improved (e.g., deeper) injection or penetration of the liquid. Figures 4A to 44 illustrate one embodiment of the device 3300, which combines an intrusion section and a pulsed air conveying section. As shown in E. As described above with reference to Figures 3A-3E, the device 3300 has an inner lip or It may include a ridge 3352 and an outer lip or ridge 3360. Lips or ridges 3352, 3360 are connected to the tip 3340 of the device 3300. When properly positioned, it can be shaped and sized to come into contact with the skin surface, It can be constructed in that way.

[0069] Referring to the front view of the chip in Figure 4B, similar to other embodiments of the apparatus disclosed herein. , extending between the outer lip or ridge 3360 and the inner lip or ridge 3352 The region or space is configured to receive one or more therapeutic fluids when the device is in use. This can be done. For example, by bringing the lip or ridge 3352,3360 into contact with the skin surface, When a vacuum source or suction source is activated, a fluid source (for example, as shown in Figures 4A to 4E) is activated. Serum and / or from cartridge C, main fluid conduit connected to the manifold system (etc.) Alternatively, other fluids are transported through one or more fluid transport ports located between ridges 3352 and 3360. It can be transported via 3346. Used fluid and / or other waste are shown in Figure In the shown configuration, a vacuum opening 3348 is similarly located between ridges 3352 and 3360. It can be removed from the interface between the tip and the skin / device. (Figures 3A-3E) As described above with reference to the apparatus, the fluid transport port 3346 and the suction or vacuum port 334 8 can be separated from each other by the desired separation distance, thereby being delivered to the skin. Serum and / or other fluids are confirmed along at least a portion of the tip before it is removed. Indeed, this can facilitate passage through serum. In some embodiments, this can be achieved by serum It can provide a longer contact time between the skin and and / or other liquids, resulting in better It can lead to therapeutic outcomes.

[0070] Continuing to refer to Figure 4, the inner ridge or lip 3352 is the inner ridge 335 One or more openings adapted to supply pulsed air to the region defined by 2 Alternatively, it may include a passage 3356. In the illustrated embodiment, an inner ridge or lip The interior of 3352 includes three separate openings or opening areas 3356. However, However, in other embodiments, the inner ridge may be more or less as desired or required. It may include a smaller opening or opening area. Regarding other pneumatic pulse configurations, As described in more detail in the specification, pulsed air or other gas is introduced into such opening 3 Selectively supplying through 356 to produce the desired spray or air-driven effect on the skin. It is possible. In some embodiments, during use, the inner ridge 3352 and the outer ridge To maintain proper contact between the 3360 and the subject's skin surface, along the inner ridge, Alternatively, strategically positioning one or more vacuum or suction ports 3342 in or near them may be... Yes, it is possible. Therefore, the use of such suction is for treating the internal ridge 3352 during use. It helps prevent or reduce the possibility of the skin surface separating from the surrounding tissue.

[0071] As shown in Figures 4A to 4E, the device has a movable needle assembly 3 inside the tip 3340. 370 may be additionally included. In the illustrated embodiment, a single movable needle assembly is It is positioned along the central part of the lip (for example, inside the inner ridge or lip 3352). However, in other embodiments, the size and shape of the movable needle assembly 3370 are described. The position, quantity, and / or finer details can be changed as desired or necessary. The assembly may include a plurality of needles 3372 that extend outward (for example, distally). Cut.

[0072] According to some embodiments, the needle assembly 3370 has a proximal position and a distal position during use. It can be configured to reciprocate between and The reciprocating motion or other motion of the Bri 3370 is achieved pneumatically or mechanically. For example In one embodiment, an air or other fluid line is located in the container where the needle assembly 3370 is positioned. It is at least partially coupled to the instrument or housing. Movable needle assembly 3370 (approximately and / or positive and / or negative flow to the associated container or housing (for example) Body pressure transfer can be used to move the needle assembly 3370 in the desired manner. Yes, it is possible. In some embodiments, the movable needle assembly 3370 is (for example, a hand pee Using a spring or other elastic member or elastic assembly S placed inside the spring It can be mounted. Therefore, in such a configuration, the rear is supported by a spring or other elastic force. The needle assembly 3370 can be elastically biased in a retracted (or proximal) direction. . Selective air transport to the needle assembly 3370 (for example, to the assembly 3370) Applying pressure or force (by using) against the spring or biasing force, needle assembly 33 This facilitates the movement of 70 from its elastically retracted position towards a more distal direction. Once the force applied to the assembly is complete, the needle can assume its retracted, proximal position.

[0073] According to some embodiments, the degree to which the needle assembly moves distally can be precisely controlled. This is possible. For example, the degree to which the needle assembly advances can be controlled by the spring or other elastic member. This can depend on the amount of force applied to assembly 3370, etc. Such parameters control the depth to which the needle penetrates the skin by the needle assembly 3370. Useful. The needle penetrates to a certain depth and reaches the subject's skin tissue (e.g., the subject's scalp). The effect can also be modified using other methods. For example, the device 3300 can use various chips The user can be provided with a choice of options, and each option is (for example, in assembly 3370) By changing the length, diameter, sharpness and / or other properties of the included needle 3372 ) Having different maximum penetration distances. In some embodiments, the user can insert the chip and / or Alternatively, the maximum needle penetration distance can be changed by manipulating the needle assembly. For example, several In this embodiment, the height of the lip or ridge can be adjusted. In other configurations, use The operator changes the orientation (e.g., depth) of the needle assembly within the handpiece to effectively control the penetration depth. It can be adjusted.

[0074] In some embodiments, the user places the needle assembly 3370 distally (e.g., on the skin surface) To selectively deploy (towards the surface), press a button or one or more other controls. To operate a device or function (e.g., a switch, foot pedal, etc.). For example, pneumatic control. In this needle assembly configuration, the user presses a button to insert the needle into the corresponding conduit of the handpiece. By introducing compressed air, force can be applied to the needle assembly. This allows the needle assembly The Swertia japonica can be moved toward the skin. Sufficient force is applied to the needle assembly. Then, the needle assembly moves sufficiently (for example, distally) to the adjacent skin surface of the subject. It can engage with and penetrate at least the surface of the skin.

[0075] In other embodiments, by operating a button or other controller, mechanically generating The resulting force acts on the needle assembly 3370, resisting the spring or other elastic force. The bri can be moved distally. Furthermore, in other configurations, the needle assembly is elastically attached. Not subject to force (e.g., does not include springs or other elastic members). For example, movable assembly The device can be moved between a proximal and distal position using a motor, gears, etc. Regardless of how the needle assembly approaches or moves away from the subject's skin surface, In that configuration, the assembly moves along several different proximal / distal positions. This is possible. In some embodiments, the available positions are clearly indicated as desired or as needed. A precise location (e.g., a location at a specific distance) or a continuous location (e.g., a location that is completely retracted) (This can be a position along any position between the initial position and the fully extended position.) Cut.

[0076] In some embodiments, during use, the treatment device 3300 is laid flat against the subject's skin. To activate the movable needle assembly 3370 only when it is moving or not moving. (For example, to move distal to the skin surface and distally through the skin surface) (It can be operated at will). Such methods using these devices are desired by the subject. It helps to avoid undesirable injuries. It forms a passage within one or more layers of skin to be treated. By using needles, additional benefits can be provided to the subject. For example, Serum and / or other fluids transported and / or placed along the tip of the device are more It can penetrate deep into the target's skin. Simultaneously with needle penetration, it pulses air into the skin tissue. By granting these benefits, these advantages and advantages can be further enhanced.

[0077] As shown in Figure 4C, the apparatus 3300 includes a vacuum source (e.g., a suction port), (e.g., a suction port), Air supply to the moving needle assembly (for selectively operating the assembly with air pressure) In, and / or pulses (for example, to supply pulsed air to the chip of a device). It can include additional ports 3302, 3304, and 3306 for connecting to an air source. Such fluid sources can be separated from the treatment system, or as requested or necessary. Depending on the requirements, it may be incorporated into the system at least partially. In some embodiments, The user of the device can monitor the suction level, needle assembly position, and / or pulse level during use. To allow for advantageous adjustment, the vacuum source, air supply source, and pulsed air source are controlled to a minimum extent. It communicates data with Joule or other control devices. In some embodiments, the assembly To adjust the delivery of air or other gases, the movement of the movable needle assembly is related to the transport of air or other gases. A button or other controller can be coupled to or incorporated into the valve structure.

[0078] According to some embodiments, the needle 3372 of the needle assembly 3370 is solid or hollow. It is possible. In some embodiments, the diameter of the needle is 0.001 to 0.050 inches (for example) For example, 0.010 inch, 0.001~0.005, 0.005~0.010, 0.010 ~0.020, 0.020~0.030, 0.030~0.040, 0.040~0.0 50 inches, diameter within the above range, etc. In other embodiments, the needle diameter is 0.00 Less than 1 inch or greater than 0.050 inches (for example, 0.050 to 0.060, 0.050). 060~0.070,0.070~0.080,0.080~0.090,0.090~ (0.100 inches, diameters between the above ranges, diameters greater than 0.100 inches, etc.) In this embodiment, the length of the needle is 0.05 to 5 mm (for example, 0.5 to 2.5 mm, 0.05 to 5 mm). 0.1, 0.1~0.2, 0.2~0.3, 0.3~0.4, 0.4~0.5, 0.5~ 0.6, 0.6~0.7, 0.7~0.8, 0.8~0.9, 0.9~1.0, 1~2, This includes lengths of 2-3, 3-4, 4-5 mm, lengths within the above ranges, lengths exceeding 5 mm, etc.

[0079] This specification specifically describes needle assemblies, or any needle penetration techniques in general, as described herein. In any embodiment of the disclosure, the needle may be solid and / or hollow. In some embodiments, the needle can be configured to selectively heat or cool. For example, in one embodiment, resistance (e.g., via electrical energy, wireless energy, etc.) Heating the needle using anti-heating, steam (e.g., hot steam) or similar techniques, thermoelectric elements, etc. It is possible.

[0080] In any of the therapeutic embodiments disclosed herein, the desired effect is applied to the skin of the subject. To produce this, one or more pulse parameters can be changed. For example, as described above. As shown, high and low pulse pressures can be adjusted. Furthermore, several In the embodiment, the duty cycle, frequency, airflow rate and, as desired or required, are specified. / Other properties can be changed. For example, the duty cycle can be changed from 20 to 60. %(For example, 20~25, 25~30, 30~35, 35~40, 40~45, 45~5 Change between 0, 50-55, 55-60% (duty cycles, etc., within the above ranges). This is possible. In another embodiment, the duty cycle of the pulsed air system is 60 Over % (for example, 60-70%, 70-80%, 80-90%, 90-95%, between the above) Duty cycles exceeding 95% or less than 20% For example, duty cycles between 0-5, 5-10, 10-15, and 15-20%. (e.g., Kuru)

[0081] According to some embodiments, pulsed The frequency of air is 2-15Hz (for example, 2-3, 3-4, 4-5, 5-6, 6-7, 7 ~8, 8~9, 9~10, 10~11, 11~12, 12~13, 13~14, 14~1 It can be changed between 5Hz and frequencies within the above range. However, other embodiments So, the frequency of pulsed air is less than 2 Hz (for example, 0~0.5, 0.5~1, 1~1 0.5, 1.5~2Hz, frequencies within the above range, etc.) or frequencies exceeding 15Hz (for example) , 15~20, 20~25, 25~30, 30~40, 40~50Hz, between the above ranges The frequency can be set to a frequency exceeding 50Hz, etc.

[0082] In other embodiments, air-based pressure along the distal end of the handpiece or other device The force pushes at least a portion of the treatment fluid or other material deeper into the skin surface. It can be applied to achieve deeper injection of fluids and / or other substances into the skin. To facilitate this, if requested or needed, for example, air, hammer or other mechanical Continuous transport using impact devices or the like can be used.

[0083] In some embodiments, the entirety of which is incorporated herein by reference, Pulse along the distal end of the handpiece or other system (e.g., pneumatic, mechanical) The pressure application may include alternating between positive and negative pressure amounts (for example, relative to atmospheric pressure). Alternatively, pulse application can be performed (for example, by air transport due to mechanical or pneumatic shock, etc.) This includes a first stage in which positive pressure is generated and a second stage in which negative pressure (or vacuum) is generated. This can be done. These first and second stages can be performed alternately depending on the desired or required frequency. It may be possible for the user to adjust it.

[0084] In other configurations, the handpiece or other treatment device or treatment system is (as described above). Contrary to what was described morphologically, both positive and negative pressure (vacuum) are present at the skin interface. It is configured to transport at times. For example, in some embodiments, the handpiece is The distal end or tip of the Swertia japonica plant should be used to treat adjacent skin tissue of the person being treated. Along the interface with the chip, one or more positive pressure zones and one or more negative pressure (or vacuum) zones It can be configured to create zones separately. Further details regarding these embodiments are disclosed in International Patent Application No. PCT / US2014 / 02 4992, filed on March 12, 2014, and published as International Publication No. WO 2014 / 151104 on September 25, 2014, the entire disclosure of which is incorporated herein by reference. Improvement of handpiece design

[0085] In some embodiments, as shown in FIG. 5, the handpiece assembly 2010 can include a flexible engagement member or shroud 2020 disposed along the distal end of the handpiece assembly 2010. As shown in FIG. 5, the engagement member 2020 can be fixed or coupled to a tip 2016 configured to be removably fixed to the distal end of the body portion 2012 of the assembly 2010. However, in other embodiments, the engagement member 2020 and / or the tip 2016 can be affixed to the body portion 2012 of the handpiece assembly 2010. In still other configurations, the engagement member 2020 can be sized and shaped to be removably or fixedly coupled to the body portion 2010, as desired or necessary (e.g., regardless of the presence or absence of a tip), or can be adapted therefor. In some embodiments, the body portion 2010, the tip 20 16 and / or the engagement member 2020 can form a single structure or an integral structure. For example, some or all of the various components of the handpiece assembly 2010 can be coupled to a single component or structure. Regardless of its exact structure and / or design, the engagement member or shroud 2020 is such that it can be sized and shaped to be removably or fixedly coupled to the body portion 2010, as desired or necessary (e.g., regardless of the presence or absence of a tip), or can be adapted therefor. In some embodiments, the body portion 2010, the tip 20 16 and / or the engagement member 2020 can form a single structure or an integral structure. For example, some or all of the various components of the handpiece assembly 2010 can be coupled to a single component or structure.

[0086] Regardless of its exact structure and / or design, the engagement member or shroud 2020 is The device is configured to engage with a portion of the subject's skin and to seal the skin at least temporarily. This is possible. For example, in some embodiments, the engaging member 2020 is the subject being treated. It can be configured to engage with one or more external parts of the scalp, face or other skin surface. The engaging member 2020 has a distal end that contacts and adjusts the target skin surface. It may comprise one or more materials and / or features or configurations that facilitate integration. For example, the engaging member 2020 is made of rubber (e.g., silicone rubber) and / or other elastic material. It may include Tomer material. As shown in Figure 5, the engaging member 2020 is the target of the subject. To enable contact and engagement with the skin surface (e.g., the subject's scalp, face, etc.), as requested or necessary. If necessary, one or more bellows or other parts are adapted to facilitate the deformation of the engaging member 2020. This may include parts, features, components, and / or configurations.

[0087] Continuing to refer to Figure 5, the engaging member 2020 consists of one or more (for example, 3, It may be equipped with bellows or other foldable members (such as 4, 5, 6 or more) To be able to. As described herein, bellows or other foldable members along the distal end (For example, an end configured to come into contact with and engage with the subject's tissue, such as the scalp or face) It can be configured to adapt to a specific degree of unevenness (along the part). However, In the embodiment shown in Figure 9, the engaging member 2120 is a bellows or other folding It does not have any possible components. Furthermore, the engaging member or shroud 2020 is in use This provides the desired level of rotation between the handpiece 2010 and the adjacent body portion 2012. It can be configured in such a way. In other words, in some configurations, the handpiece assembly During use of the bri, the engaging member 2020 will be adjusted according to the length and flexibility of the engaging member 2020. The longitudinal axis of the main body portion 12 and the axis perpendicular to the skin surface being treated (therefore, the distal end of the engaging member) Between the surface forming the plane, the angle is 0 to 70 degrees (for example, 0 to 10, 10 to 20, 20 to 30, 3 Bend to angles between 0 and 40 degrees, 40 and 50 degrees, 50 and 60 degrees, 60 and 70 degrees, etc. It is possible.

[0088] Figures 6 and 7 show a handpiece assembly with an engaging member or shroud 2020. The following shows embodiments of the use of the device. Specifically, these figures show a device with a fluid (e.g., air) at its distal end. It is also configured to supply a pulsed flow of ) and to supply a vacuum force or suction force to the distal end. Regarding the handpiece assembly 2010, the engaging member 2 during two different operating stages This indicates 020. As shown in Figure 6, the engaging member or shroud 2020 is in the normal state. The bellows 2028 are in an expanded shape. In Figure 7, the bellows 2028 are compressed against each other. It will be crushed. As described herein, such crushing occurs when the user assembles the handpiece. Press the Nbry 2010 toward the target skin surface S (e.g., the subject's scalp or face) or By biasing and / or for any other reason, the engaging member 2020 This is due to the vacuum force that is transported into the defined internal space. According to several embodiments, For example, due to bellows and / or due to the use of flexible materials, the engaging member The Shroud 2020 will expand during use as requested or as needed. 20-80% of the length (for example, 20-30, 30-40, 40-50, 50-60, 6 configured to crush up to 0 to 70, 70 to 80%, percentages therebetween, etc.) It is possible.

[0089] According to some embodiments, the engagement member or shroud 2020 can be configured to be attached to the tip of an existing handpiece. However, in other embodiments, the engagement member 2020 is configured to be provided with the tip or (e.g., the handpiece assembly and the engagement member 2020 form a single structure or an integral structure) configured to be provided on the body portion of the handpiece assembly. Regardless of its exact configuration and incorporation into the handpiece assembly, the distal engagement member or shroud 2020 can advantageously compensate for and conform to differences in the shape of a person's scalp (or other target skin surface, e.g., facial site) or the shape of the target skin surface of the individual being treated. It can be. In other embodiments, the engagement member 2020 is configured to be provided with the tip or (e.g., the handpiece assembly and the engagement member 2020 form a single structure or an integral structure) configured to be provided on the body portion of the handpiece assembly. (e.g., such that the handpiece assembly and the engagement member 2020 form a single structure or an integral structure) Regardless of its exact configuration and incorporation into the handpiece assembly, the distal engagement member or shroud 2020 can advantageously compensate for and conform to differences in the shape of a person's scalp (or other target skin surface, e.g., facial site) or the shape of the target skin surface of the individual being treated. Regardless of its exact configuration and incorporation into the handpiece assembly, the distal engagement member or shroud 2020 can advantageously compensate for and conform to differences in the shape of a person's scalp (or other target skin surface, e.g., facial site) or the shape of the target skin surface of the individual being treated. Regardless of its exact configuration and incorporation into the handpiece assembly, the distal engagement member or shroud 2020 can advantageously compensate for and conform to differences in the shape of a person's scalp (or other target skin surface, e.g., facial site) or the shape of the target skin surface of the individual being treated. It can be.

[0090] As described herein, in the embodiment shown in FIG. 5, the engagement member 2020 can be a separate component (e.g., fixedly or removably) attached to the tip 2 016. However, in other configurations, the tip 2016 can be manufactured with the engagement member or the shroud 2020 such that the tip 2016 is configured to form a single structure or an integral structure with the engagement member. The engagement member or shroud 2020 can be placed or fixed to any tip disclosed herein, including the tips described and illustrated in the applications incorporated herein by reference. For example, the engagement member <​​​​​​​​​​​​(including spiral members, posts, etc.) or chips including polishing surfaces, suction conveyance to skin surfaces and fluid conveyance In addition to providing delivery, it also delivers (e.g., pulsed or non-pulsed) to the skin surface being treated. A tip configured to supply air (by a certain method), with or without a needle , transported along the interface between the skin and the chip, or water or other substances present there The liquid dissolves the treatment material and releases it onto the skin surface, along the tip (for example) It can be bonded to a chip or the like containing therapeutic materials (solid, semi-solid, gel, or other non-liquid forms). Yes, it is possible. The chip described in one or more of the following applications can be attached to a locking member or shroud. Can be used together with: Filed on December 30, 2008, and approved on January 1, 2013 U.S. Patent Application No. 12 / 346,58 was issued as U.S. Patent No. 8,343,116. Patent No. 2, filed on March 29, 2006, and granted U.S. Patent No. 8,048 on November 1, 2011. U.S. Patent Application No. 11 / 392,348, issued as No. 089, July 8, 2010. Filing on [date] and issued as U.S. Patent No. 8,814,836 on August 26, 2014. U.S. Patent Application No. 12 / 832,663, filed on March 12, 2014, and 2 Countries whose information was published on September 25, 2014, under the international publication number WO2014 / 151104. International patent application no. PCT / US2014 / 024992.

[0091] The engaging member or shroud 2020 is attached to the tip (the main body of the handpiece assembly). or fixed (directly to other components) (for example, by mounting or removable) In one embodiment, the engaging member or shroud 2020 is attached by one or more mounting methods or It can be fixed using a mounting device. For example, the engaging member 2020 is as required or If necessary, press-fit connections or friction-fit connections, adhesives, screw connections, one or more fasteners, Using welding or the like, the tip, body and / or part of the handpiece assembly 2010 It can be fixed to any other part or component.

[0092] As mentioned above, the application may be uneven on the surface or overall of the scalp being treated. Or to conform to other uneven skin surfaces (e.g., facial skin, neck, arms, legs, etc.) A combination of one or more soft, flexible materials (e.g., silicone rubber, foam, latex) S, vinyl, other types of rubber and / or elastomer materials, other flexible natural materials It may include (and / or synthetic materials). In some embodiments, engaging members or The distal end of the shroud 2020 is designed to protect the surrounding members or portions of the target adjacent to it during use. It is configured to form a seal between itself and the skin surface.

[0093] Figure 8 shows the suction force transport and fluid transport to the tip, as well as (e.g., pulsed or non-pulsated) Engaging member fixed to a tip configured to supply separate airflows (in a russ-like manner) Alternatively, an internal diagram of the Shroud 2020 is shown. For example, such a chip is described in the U.S. Patent Publication. Number 2014 / 0343574 (see, for example, Figures 4-5C) and International Public Publication number WO2014 / 151104 (for example, Figures 4-5C and Figures 22A-23) As described in more detail in (see E), both applications are incorporated herein by reference. This is incorporated and forms part of the present application.

[0094] In the embodiment shown in Figure 8, the handpiece assembly is modified as needed or as required. For example, inside the main body of the assembly and / or any other component element and / or Alternatively, fluid (e.g., water, other) is delivered to the skin surface being treated via one or more external passages. The invention provides serum and therapeutic materials, etc. As described herein, the embodiment shown in Figure 8 is therapeutic A separate component configured to supply force (for example, continuously or intermittently) to the skin surface. It is configured to supply an airflow. In some embodiments, such a positive airflow The flow of air pressure allows fluids transported or positioned along the skin surface being treated to penetrate deeper into the tissue. It can encourage movement to the deeper parts of the tissue. It promotes fluid transport to deeper layers of skin tissue. Technologies like these facilitate skin treatment procedures and provide greater benefits to those being treated.

[0095] In the embodiment shown in Figure 8, along the distal end of the handpiece assembly (therefore, For example, a vacuum is formed inside the engaging member or shroud 2020 (at least partially). In such cases, the engaging member or shroud 2020 shall always maintain a seal with adjacent tissue during use. It can be configured to hold. For example, even if fluid is delivered to the surface of the skin, the surface of the skin Even when separate airflows are delivered to the surface, the intermittent suction force generated inside the engaging member 2020 Even if it has properties, and / or if there are any other factors or considerations, Such a seal can be maintained. However, in other embodiments, the engaging member and The Shroud 2020 is designed to intermittently lose contact with adjacent skin surfaces and lose its seal. This is done. Handpiece assembly, engaging member or shroud 2020 and / or Regardless of the actual way in which other components or structures of the system are configured, the engaging member Alternatively, by using the Shroud 20, various (regardless of the unevenness of the skin surface) It can promote contact with the skin surface and the maintenance of that contact. In connection with this, engagement Component 2020 facilitates the capture and removal of fluid from the skin surface being treated, thereby This allows us to provide a cleaner treatment with less contamination.

[0096] As described above, the engaging member or shroud is (for example, less than in the embodiment of Figure 5) Including bellows or other foldable members, or bellows or foldable parts It can also be made shorter (excluding the material). Such a configuration of the engaging member 2120 is shown in Figure 9. In some embodiments, such an engaging member or shroud 2120 is used to target It can be used when the scalp or other skin surface has few irregularities (for example, the skin surface is flatter). It can be used. In some embodiments, for example, a handpiece against the skin surface. To provide more direct control of the assembly, the gap between the tip and the skin surface is reduced. To do so, and / or for any other reason or purpose, use as requested or as needed. The user prefers to use a shorter engaging member or shroud 120, as shown in Figure 9. There are cases where this is the case.

[0097] As described above, the engaging member or shroud can be attached using any type of tip, and / Alternatively, it can be used in any type of skin treatment procedure. For example, handpiece acetone The humb may be equipped with an engaging member or shroud for use in hair growth treatments. For example, the engaging member may be one or more other hair growth treatments or processes (e.g., hair implantation, puncture). Before, during, or after polishing, etc., it promotes the delivery of hair growth agents to deeper layers of the scalp. Yes, it is possible. For example, in some embodiments, an engaging member or shroud is used. This drives one or more therapeutic materials or other components deeper into the scalp or other target surface. Such materials and / or other components may promote this. However, it does not contain amino acids, antioxidants, minoxidil, other antihypertensive vasodilators, or other hair growth stimulants. Hair growth agents, other natural or synthetic hair growth materials, skin tightening agents, platelet-rich plasma (PRP), Stripping agents, peptides, bleaching agents, anti-acne agents, human growth factors, cytokines, soluble collagen N, antioxidants, matrix proteins, epicatechin, catechin and / or other fungi Enols and / or other antioxidants, neurotoxins, serums, salicylic acid, other anti-acids and anti-acne substances, microcapsules, capsules, other time-release products and time-release materials Quality, water (e.g., distilled water, tap water, filtered water, etc.), physiological saline, other diluents, excipients or Solvents, vitamins, chemical stripping agents, lotions, pain relievers, whitening agents or brightening agents, Peptides Hydrogen, peeling agents, acids, anesthetics, pharmaceuticals, other inactive or active compounds, other fluids A body or substance, a combination or mixture of the above, and / or one or more internal / external Includes any other substances from the fluid source.

[0098] However, handpieces equipped with distal engaging members or shrouds 2020, 2120 By using the assembly, it can be used for hair growth purposes as well as for any other skin treatment procedure. It is possible. For example, a handpiece assembly with an engaging member attached is a basic skin Skin polishing treatments (e.g., micro-skin polishing with or without fluid transport), acne, whitening, skin Tightening, anti-aging, oily skin, lip care / plumping, damaged skin, blackhead / sebum removal. It can also be used for extraction or other purposes. Transport of hair growth treatment agents using other processes or procedures

[0099] As described herein, the delivery of hair growth agents to the skin and into the skin of the subject is one or more This can be facilitated and / or supplemented by additional steps or treatments. The procedure or treatment may involve applying fluids and / or other treatments to the target skin surface as requested or as needed. It can be implemented or used before, during, and / or after the material is transported.

[0100] In some configurations, for example, therapeutic fluids and / or other therapeutic materials (e.g., amino acids) Acids, antioxidants, minoxidil, other antihypertensive vasodilators, other hair growth stimulants, other natural ingredients Hair growth is desired before, during, and / or after skin peeling (using artificial or synthetic materials, etc.). It is delivered to the target skin surface. In some configurations, the fluid and / or other material is delivered to the skin. via the handpiece assembly (for example, the tip or distal end of the handpiece assembly) Vacuum or suction is used to transport one or more therapeutic fluids and / or other materials toward It is delivered to the skin (with the help of force). The tip or distal end of the handpiece assembly is delivered to the skin. It can be configured to selectively polish or strip. For example, handpiece acetate Along the tip or another part of the blade, one or more polishing structures or polishing features (for example, Arrange the spiral member, post, other protruding member, polishing disc or polishing surface, diamond, etc. It is possible. In some embodiments, the handpiece assembly is applied to the target skin tissue. In contrast, while being moved, such abrasive structures or features selectively abrasively polish the skin tissue. It can be peeled off. As described above, hair growth is promoted by polishing or peeling. The therapeutic fluid and / or other materials configured to deliver to deeper layers of skin tissue. This can encourage the use of therapeutic fluids and / or Other materials may help achieve hair growth and / or other benefits related to hair health. It can enhance benefits (for example, strengthening hair, improving the viability of hair follicles, etc.).

[0101] Further details on devices, systems, and methods for polishing and / or exfoliating skin Filing on December 30, 2008, and granted U.S. patent no. 8,343,1 on January 1, 2013. U.S. Patent Application No. 12 / 346,582, issued as No. 16 on March 29, 2006. It was filed and issued as U.S. Patent No. 8,048,089 on November 1, 2011. U.S. Patent Application No. 11 / 392,348, filed on July 8, 2010, and granted August 2014. U.S. Patent Application No. 12 / 83 was issued on the 26th of the month as U.S. Patent No. 8,814,836. Patent No. 2,663, filed on March 12, 2014, and publicly disclosed on September 25, 2014. International patent application PCT / US2 published under application number WO2014 / 151104 Disclosed in publication 014 / 024992, which is incorporated herein by reference in its entirety. ru.

[0102] The delivery of the hair growth agent to the target skin surface, involving abrasion or exfoliation, is a multi-step process (e.g., two steps). The process may include steps of 3, 4 or more, etc. For example, several embodiments The first step of the process includes polishing and / or exfoliating the skin tissue. During and / or after the polishing and / or stripping process, one or more as described above The above treatment fluids and / or other materials (e.g., amino acids, antioxidants, minoxidil, Other antihypertensive vasodilators, other hair growth stimulants, other natural or synthetic materials, etc.) into the tissue It can be transported advantageously. Such fluids and / or other materials promote skin growth. It can be configured to promote progress.

[0103] According to some embodiments, the post-process of polishing / stripping and conveying treatment fluids / other materials As such, one or more additional steps or procedures can be selectively performed. For example, Applying one or more light therapies to the target skin tissue can further promote hair growth. Such light therapy is not necessarily limited, but may use red light if requested or as needed. For example, infrared light, ultraviolet light, and / or different frequencies and / or different It can include different types of light delivery. Light delivery to the skin can be in one or more different ways. Light can be beneficial for hair growth. For example, light can be used to deliver treatment directly to skin tissue. Alternatively, light can activate or alter the function of materials delivered to the skin. It can be used for this purpose. Implementation form of a light emission stick that can be used in such procedures. The state will be explained in more detail below with reference to Figures 10A and 10B.

[0104] In some embodiments, before, during, or after a hair growth treatment or other skin treatment. After placement, one or more forms of light can be irradiated onto the subject's skin. The type and intensity of the light, Power, frequency, wavelength, exposure time, and / or other characteristics may vary depending on the specific application or use. Therefore, it can be changed as requested or as needed. In some embodiments, one of the light sources More than one of the properties can be changed during and / or between procedures. In one embodiment, as shown in Figures 10A and 10B, the light is provided by one or more LEDs or It is equipped with other illumination sources. As with other forms disclosed herein, the light is for fine skin polishing. It can be incorporated into or attached to the handpiece being used. However, In other embodiments, the light source is separate from the handpiece assembly for fine skin polishing. It belongs to them.

[0105] In some embodiments, the options are for the subject or the user administering the treatment to the subject. This allows for the provision of two or more different types of light sources. For example, Figures 10A and 1 Referring to 0B, one of the optical sticks 402 emits blue light (for example, a wavelength of about 475 nm) One light stick 404 is configured to emit light (for example, about 6 It is configured to emit light having a wavelength of 50 nm. In some embodiments, Irradiation with light in the "red" wavelength range (e.g., 780 nanometers (nm) to 622 nm) is 1 One or more other treatment steps (e.g., fluids into and / or into skin tissue and / or skin tissue) or transport of other medical materials, vacuum or positive air pressure, pulse application, puncture, massage, micro Hair piercing (with or without skin abrasion, other mechanical or other types of vibration, heating / cooling, etc.) Helps to stimulate and / or promote hair growth. One or more sticks to have other colors of your choice. Alternatively, other light sources can be provided. Any other color or light can be provided upon request or as needed. It can be projected. For example, select an adjustable single light stick (intensity, power - In addition to selecting and / or other properties, or as an alternative to them, select the precise wavelength of light. You can choose.

[0106] One or more light sources are configured to administer hair growth treatment, any of the light sources disclosed herein. It can be incorporated directly or indirectly into the handpiece assembly. For example, an annular Light is (for example, the same or similar as described herein with reference to Figures 5 to 9) Placed along or near the lip of the distal tip of the doheld assembly (or ) It can be partially embedded within the top. In other embodiments, light is directed to the outer surface of the assembly. It can be mounted in a removable manner along the lines.

[0107] In some embodiments, the use of light is applied to the skin surface of the subject after or during transport. To chemically or biochemically "activate" the above therapeutic fluids and / or other substances It is composed of one or more therapeutic or beneficial results by activating specific substances. This can provide red light, blue light and / or other light. By using it, it is possible to provide one or more direct benefits to the targeted skin tissue. In some embodiments, for example, phototherapy using red or blue light complements hair growth promotion. It can be used for that purpose.

[0108] In some embodiments, the light is used to heat the subject's skin and adjacent tissues, and / Alternatively, it can alter or affect at least partially (for example, at the cellular level). It can be used for scrubbing. For example, in skin treatment procedures (e.g., fine skin polishing or During a specific period of hair growth treatment (with or without skin vibration), before, during, or after the treatment. Later, a heat-generating or heat-inducing light source can be directed towards the skin. The light source is a light bulb (for example). This can include incandescent, fluorescent, low-pressure sodium, high-intensity discharge, etc., LEDs, lasers, etc. As will be explained in more detail below, heating the skin provides one or more benefits to the subject. This can be done, for example, by heating skin tissue (e.g., serum and / or (This allows other therapeutic fluids or substances to penetrate deeper into the skin surface) of the subject Pores can be opened or widened. By heating the skin, (for example, treatment) (To promote improved healing and recovery after treatment) Increase blood circulation in adjacent blood vessels. It's also possible.

[0109] Further details regarding phototherapy were filed on March 12, 2014, and the patent application was filed on September 2, 2014. International patent application P was published on the 5th as international publication number WO2014 / 151104. This is described in CT / US2014 / 024992, and the entire text is referred to herein by reference. It will be incorporated into it.

[0110] According to some embodiments, phototherapy is performed using (e.g., a phototherapy handpiece or other) (Using a device or system) wavelengths of 610-650 nanometers (nm), for example This includes treatment using light configured to emit light in the "red" range. Phototherapy involves emitting light with wavelengths of 800-1,050 nm, for example, in the infrared range. This includes treatment using light configured as follows. In other embodiments, the phototherapy uses light at 410-425 nm. This includes treatment using light configured to emit light in the wavelength range, for example, "blue." In some embodiments, the power of the light applied to the skin tissue is adjusted as needed or as required. , 1cm 2 40-120 joules / cm² 2 (For example, 40-50, 50-60, 6 0-70, 70-80, 80-90, 90-100, 100-110, 110-120 Joules / cm², power levels between the above, 40 joules / cm² 2 Less than level or 1 20 joules / cm² 2 It can be set to a level exceeding that level.

[0111] Any embodiment of phototherapy, without limitation, may include one or more LEDs. Light can be emitted using a light source or configuration of choice. In some embodiments, To promote hair and / or hair growth, alone or in combination with one or more treatment steps. In addition, the emitted light is selectively applied to the skin (at one or more frequencies, wavelengths, power levels, etc.). It is possible to use light to treat acne, prevent aging, wrinkles, etc. The skin can also be supported in more than one other way.

[0112] If requested or as needed, one or more additional treatment steps and / or Devices can be incorporated. For example, as an alternative to skin abrasion / exfoliation and / or phototherapy. Alternatively, or in addition to those, the potential for hair growth brought about by specific treatments is further enhanced. To increase this, other energy carriers (radio frequency (RF) energy, microwave energy) - Ultrasonic energy, laser, iontophoresis, etc.), thermal control (for example, another one) Cooling and / or heating of the tissue before, during, and / or after the above treatment steps. ), mechanical vibration, massage, etc. may be used.

[0113] In some embodiments, to improve hair growth treatment, the target scalp or other skin surface is targeted. Heat can be transferred to the surface. For example, as mentioned above, selective light transport can be used. This can facilitate the application of heat to the target skin surface. Heat transfer is the desired healing Depending on the therapeutic effect, treatment protocol, etc., heating or cooling may be included. Figure 1 Refer to 1A and Figure 11B, another device configured to heat or cool the target skin surface. Embodiments of this handheld device are described below.

[0114] In some configurations, exposing the skin to high and / or low temperatures promotes hair growth and / It can support various aspects related to other skin treatment techniques and skin treatment procedures. For example, as described herein, the pores of the skin are opened by heating the skin. This improves the penetration and movement of serum, other therapeutic fluids, or therapeutic materials into the skin. This can be achieved. Furthermore, by cooling the skin, the pores are closed at least partially, and first This allows treatment fluids and / or other materials that enter the pores to remain in the skin for a longer period of time. ru.

[0115] In some embodiments, before and during a skin treatment procedure (e.g., a hair growth promotion procedure) And / or after the procedure, one or more devices are used to electrically cool and / or heat the skin. A device (e.g., a handheld device) can be used. Such heating and cooling devices One embodiment of the stem is shown in Figures 11A and 11B. As shown in the figures, the system is thermal dot It may include a King Station 510. In some embodiments, docking stations Station 510 houses the thermally regulated handheld assembly 600 and recharges thermally. It is provided with one or more holes, ports, or openings 514, 518 for use.

[0116] Continuing to refer to Figures 11A and 11B, the thermal recharging station 510 is one It can be in thermal communication with the above heating and / or cooling elements (not shown). In this embodiment, one or more thermoelectric elements (e.g., Peltier elements) are located at station 510 It is located along the outside and / or inside of the wall, and / or within the wall. However, Furthermore, any other type of heating and / or cooling element can be used. In that embodiment, the thermal control element is (for example, schematically represented by circles 530 and 532 in Figure 11A) (So ​​that it can be positioned) along the outer surface of the docking station wall. Quantity of thermal control elements Regardless of type, position, spacing, orientation and / or configuration, the thermal handpiece assembly 6 The adjacent portion of station 510, including holes 514 and 518 that accept 00, is electrically charged. The elements can be adapted to be heated or cooled.

[0117] In some embodiments, the station is made of, for example, aluminum, copper, or other metals. It contains one or more thermally conductive materials, such as alloys. As shown in Figure 11B, holes 514, 518 One or more of these may include pins, rods, or other protruding members 516, 520. As will be explained in more detail below, the thermal control handheld assembly 600 has a central opening. It may include parts. In some embodiments, the assembly 600 is the assembly It is almost hollow along the center line. Therefore, it fits into holes 514 and 518 of station 510. When placing, assembly 600 can be conveniently rested on or positioned on pins 516, 520. Therefore, as shown in Figure 11A, the assembly is stationary for thermal recharging. When positioned within the 510, pins 516 and 520 almost vertically support the thermal handheld assembly. It can be reliably maintained in a perpendicular direction.

[0118] Thermoelectric elements and / or other heating and / or cooling elements of the station are manufactured When operated, the holes in the station are heated according to the desired thermal control effect of station 510. Or it can be cooled. In some embodiments, the station 510 is heated or When using thermoelectric elements for cooling, an additional station (not shown) can be placed on the opposite side of the thermoelectric element. By arranging (as shown), additional stations can also be heated or cooled (e.g., main station It can receive the opposite thermal effect.

[0119] Assembly 600 comprises an inner core and an outer housing or outer shell. Yes, it is possible. In some embodiments, the inner core is made of copper, aluminum and / or other suitable materials. Includes high heat-conducting materials (e.g., beryllium, other metals or alloys). In the application method, copper and / or other materials are coated with one or more layers of nickel, chromium, etc. (for example) The outer housing can be plated. The outer housing can grip the assembly 600. (To prevent users from feeling excessively or uncomfortably hot or cold) Relatively low heat Conductive ABS, nylon and / or any other plastic, or other material It can include.

[0120] According to some embodiments, the thermal handheld assembly 600 is connected to the assembly This includes an internal lumen or opening that extends fully or partially. Assembly 600 When configured for suction, the proximal end of the assembly is arranged to communicate with the vacuum conduit and fluid. It can be placed there. In such a configuration, the conduit is in fluid communication with a vacuum source or negative pressure source. They are arranged in such a way. However, in some embodiments, the heating or cooling system is absorbed It is configured to be used without a charge.

[0121] The handheld assembly 600 may include a distal head. (Illustrated Embodiment) The head includes a circular or rounded shape with a substantially smooth surface. In some embodiments, The head is in fluid communication with one or more internal lumens or internal passages of the 600 assembly. It has an opening. In some embodiments, the head is a single structure with the core of the assembly 600. It forms part of the assembly. As such, the head is station 5 One or more high-voltage components, when placed within the 10 holes, can be heated or cooled relatively quickly. It favorably contains thermal materials (e.g., copper).

[0122] Regardless of its exact shape, size, configuration and / or other characteristics, a thermal handheld door Swertia japonica 600 is used to selectively heat or cool the skin surface of a subject. This can be done. As described above, in one embodiment, the pores of the skin are opened and / or one or more To bring about the above additional benefits, treat the surface to be treated (e.g., scalp, other skin where hair growth is desired). The skin surface, etc., can be heated first. Regardless of whether or not skin polishing is performed, the pores will open. The fluid transport process can be carried out in a state. This allows (for example, preheated Any serum for hair growth, other treatments (along the skin surface) are transported to the working end of the skin treatment device. Fluids and / or other substances can open skin pores more deeply and / or more easily. It can pass through the treatment protocol (e.g., fluid transport only, fluid with micro-skin polishing). Following transport, etc., the user uses the cooling adjustment assembly 600 to treat the treated skin surface. It can cool the skin. By cooling the skin surface, the pores of the skin can be cooled at least partially. To close off, thereby trapping potentially beneficial serum and / or other components within the skin. Such treatment methods offer faster recovery times, fewer complications, and / or It may be offered for one or more other benefits or advantages.

[0123] According to some embodiments, the degree of heating or cooling of the thermal assembly 600 is (for example) If, a thermoelectric element or any other heating or cooling element to thermally regulate station 510. It can be adjusted and controlled by changing the duty cycle of the child. In some embodiments, the station 510 and the station are configured to heat The operating temperature of the handheld assembly will not reach dangerously or uncomfortably extreme levels. To do this, a thermostat and / or other temperature detection devices are used.

[0124] In other embodiments, the skin surface is heated or cooled using any other method or apparatus. This is possible. For example, the energy or other forms described herein (e.g., R The skin can be heated using one of the following methods: F, ultrasound, microwaves, etc. In terms of form, (e.g., vial or cartridge, manifold system or tower) Liquids, serums, and / or other liquids transported from the system's bottles, etc., to the tip of the micro-skin polishing device. Other therapeutic fluids can be heated or cooled before reaching the skin surface. Therefore , a handheld device for micro-skin polishing or a fluid system coupled to said handheld device One or more heating or cooling elements can be incorporated into it. Rollerball / porous assembly for fluid / therapeutic material transport

[0125] In some embodiments, various therapeutic devices, systems, and / or other therapeutic devices are disclosed herein. The method involves applying hair growth fluids and / or other materials to a target skin site (e.g., the scalp surface of the subject). To facilitate transport to the surface, alternative handheld assemblies and / or other devices It can be used in conjunction with a system or installation. See Figures 12A to 15 for details. Examples of eel-catching devices and systems are described below.

[0126] One of the assembly 900 equipped with a rollerball and configured for use in hair growth treatment. Embodiments are shown in Figures 12A and 12B. The illustrated assembly 900 is a single, standalone structure. Alternatively, it includes a handpiece and tip integrated into a single structure 910. Several implementations In this configuration, such combined handpieces and tips are replaced between uses. It can be configured to be disposable in this way. According to some embodiments, the assembly 900 is a cartridge configured to be fixed to the combined handpiece / tip 910. It is equipped with a jerk or other fluid source 940.

[0127] Continuing to refer to Figure 12B, the distal end 942 of cartridge 940 is the cartridge When 940 is positioned, the ro is sent through the inside of the combined handpiece / tip 910. It may include a rollerball 944. In some embodiments, the rollerball 94 4. When assembly 900 is ready for use, the combined handpiece / tip 910 It reaches the distal end or its vicinity. This allows it to reach the skin surface of the subject (e.g., scalp). While moving assembly 900, the rollerball touches the skin surface being treated and at least partially It can come into contact with and rotate. As the rollerball 944 rotates, the combined The distal end of the handpiece / tip 910, and therefore the fluid from cartridge 940 to the skin surface It can facilitate the transfer of the contents.

[0128] As shown in Figures 12A and 12B, the proximal end 945 of cartridge 940 is It may include a closing member 946 that surrounds the inside of the ditch 940 to seal it. In some embodiments, the inside of the cartridge 940 can be opened, refilled, and closed. Yes, it is possible. However, in other configurations, the cartridge 940 remains sealed at all times. It is configured in such a way that the cartridge can be disposed of after use. Regarding cartridges that can be opened and cartridges that are designed to maintain a seal. The above disclosure applies to any of the assembly configurations or variations thereof disclosed herein. It is possible.

[0129] In some embodiments, the car included in assembly 900 in Figures 12A and 12B The 940 cartridge can be reused between treatment procedures (e.g., hair growth treatment). For example, when a subject completes a specific treatment session, the subject will receive (two or more different (To the extent that serum or other therapeutic materials have been used) one or more cartridges used You may be allowed to take the cartridge home. Therefore, the person concerned may take the unused cartridge next This can be incorporated into the treatment session, thereby eliminating waste and reducing the overall treatment cost. It can be suppressed. In some embodiments, the subject is given the corresponding unused cartridge One or more serums and / or other materials contained within the 940 package, during an office visit. You may instruct them to apply it to the scalp or other skin between visits. Therefore, the cartridge To prevent contamination of the cartridge and its contents, and to prevent evaporation, leakage, or other loss of the cartridge contents. Prevents damage to the cartridge (for example, the rollerball positioned along the distal end of the cartridge). To protect (944) and / or to provide one or more additional benefits or advantages, Use the cap 950 to protect the distal end 942 of the cartridge between uses. It is possible. The Rollerball 944 is for use between office visits and appointments. This can facilitate the application of the fluid to the scalp or other skin surface of the desired subject. For example, By using a rollerball, it is possible to perform a procedure without using suction or a handpiece. The fluid can be advantageously delivered from inside the cartridge 940 to the skin surface of the subject. Thus, such embodiments provide an overall benefit for hair growth and / or other skin treatment procedures. It can be advantageously enhanced.

[0130] In some embodiments, during the treatment procedure, for example, two or more main hair growth serums or growth serums are used. Hair materials can be used. Therefore, during the first visit to the specialist, the subject will undergo two steps. After receiving treatment, the first formulation is formed in the process (for example, with or without vacuum application). It is first applied to the surface of the subject's skin. The next step is to apply a second serum or other fluid or The material is applied to the skin. In some embodiments, the user then proceeds as described herein. A cartridge or other fluid container is provided as such. Such a cartridge is its This can be used to give experts an advantage in implementing the next steps during subsequent visits. The elephant handlers, upon request or as needed, will receive these serums during the visit according to specific protocols. Alternatively, you may be instructed to regularly apply one or more of the fluids to your skin.

[0131] As described herein, the combined hands included in the assemblies of Figures 12A and 12B Piece / tip 910 can be discarded during use or a series of procedures. By using such disposable parts, contamination between subjects and / or between procedures can occur. This reduces the possibility of transmission, thereby improving the overall hygiene and safety of skin treatment procedures. It is possible.

[0132] Continuing to refer to Figures 12A and 12B, the combined handpiece / tip 910 is , including a suction port or conduit 918 configured to be in fluid communication with a vacuum source. Yes, it is possible. In the illustrated embodiment, the suction port 918 is connected to the handpiece / tip component 910. It extends along the outside (for example, at an angle). However, in other configurations, The suction port or conduit 918 may be placed within the assembly 900 as desired or as needed. They can also extend partially or completely. In yet another embodiment, the assembly The 900 is not configured to be in fluid communication with a suction source or vacuum source. Therefore In such a configuration, the assembly includes suction ports or vacuum ports, passages, conduits, etc. It is not necessary to have a related component or related structure.

[0133] In any of the embodiments disclosed herein, the cartridge, handpiece and / or a rollerball or similar structure along the distal end of the tip, (e.g., system (From a reservoir in a cartridge or other container arranged to communicate with the fluid) It can also be replaced with one or more other structures that facilitate the selective delivery of fluid to the skin surface. For example, as shown in the embodiment of Figure 13, the rollerball is along its distal end. It can be replaced with a core or other fluidically porous member 1044.

[0134] Referring to Figure 13, the distal end 1042 of the cartridge 1040 includes the core member 1044. It is possible. In some embodiments, the rollerball 944 is used in the assembly. When ready, it reaches the distal end of the combined handpiece / tip, or near it. Furthermore, to the skin surface of the subject (for example, the scalp or other skin areas where hair growth is desired) While the assembly is moving, the core member 1044 is in at least partial contact with the skin surface being treated. and deliver fluid from the fluid reservoir of the cartridge or other container 1040 to the skin surface. This is possible. The core member 1044 can be, for example, foam, porous stone, sponge or other material. One or more porous materials or porous features, porous structures or open or semi-open structures It may include another material or component including the structure. In some embodiments, a core or other The porous member 1044 is included in the water tank of a cartridge or other container member. It can be impregnated with fluid. Therefore, the core member 1044 is a cartridge or other Even when the fluid level in container 1040 is relatively low, it maintains the necessary moisture level and treats It can selectively deliver fluid to the skin surface.

[0135] Continuing to refer to Figure 13, the core member 1044 consists of one or more foams, thermoplastic materials It may include and / or other materials. The cross-sectional size of the core member is 1 / 4 inch to 2 inches. It can be in inches. In some embodiments, the core member 1044 is a cartridge or extends at least partially into the internal water tank of another container. The core member 1044 is Depending on your request or needs, for example, a circle, ellipse, square or other rectangle, or other polygon. (For example, triangles, pentagons, hexagons, octagons, decagons, etc.), irregular shapes, or any cross-section. It can include shapes.

[0136] Figure 14 schematically shows a skin treatment system 1000 similar to the system shown in Figure 13. As shown in the figure, system 1000 has a core or other porous material along the distal end of the system. The cartridge or other container 1040 may include the structure 1044. Other porous structures absorb, adsorb, and at least partially absorb a certain amount of liquid or other material. It may include one or more materials configured to hold / or retain as described herein. As such, according to some embodiments, such a core structure 1044 is used for fluid and / To deliver other materials to the scalp and / or other skin surface of the subject, a specific procedure During placement (e.g., hair growth treatment), keep the distal end of cartridge 1040 at least partially moistened. It can be used to store things.

[0137] According to some embodiments, any of the embodiments herein (for example, cartridge or a core or other porous material incorporated into the distal end of another container, handpiece, tip, etc. Structure 1044 can be used for one or more purposes. For example, several practical In the application configuration, the core material can be used to perform one or more of the following functions: ru: (i) Within a portion of the skin treatment assembly (for example, along the distal end of the cartridge, Features for storing one or more materials (along the tip of a gentian, along the handpiece, etc.) , (ii) A device as a filter (for example, for waste tissue fragments coming from the skin surface being treated) Noh, (iii) Function for delivering fluids and / or other materials to the skin surface to be treated. Etc. For example, in one embodiment, the core or other porous material 1044 is (e.g., liquid, gel) It may include therapeutic materials (such as powder). Then, the core or porous member 1040, and It transports water or another diluent to the vicinity, and the material stored in the core or other porous member. It can selectively release fuel.

[0138] According to some embodiments, as schematically shown in Figure 15, a rollerball or other The movable member 1146 is along the core or other porous member or the distal end of the structure 1144. It can be arranged. In such a system 1100, the core member 1144 and The 1146 cartridge can be positioned along the cartridge. Alternatively, As with other configurations disclosed in the details, the core member 1144 and / or rollerball 114 6 (or a combination thereof) are the handpiece, the tip of the skin treatment assembly and It can be placed at the and / or any other arbitrary position. In such embodiments, the roller The ball 1146, with the help of the core member or structure, is contained within the cartridge or other container. It can maintain fluid communication with the contained fluid. In other words, the proximal part of the rollerball The edges can maintain a favorably moist state with the help of the core material.

[0139] To deliver therapeutic fluids and / or other materials to the scalp or other target skin surface of the subject. Further details regarding the use of rollerballs, core components and / or other porous structures This application was filed on December 22, 2015, and received international publication number WO2 on June 30, 2016. International patent application PCT / US2015 / 06, published as PCT / US2015 / 067531. It is described in publication No. 7531, which is incorporated herein by reference in its entirety. Implant / Transplant

[0140] In some embodiments, various therapeutic devices, systems, and / or other therapeutic devices disclosed herein are also This method can be used in conjunction with hair transplantation to further enhance hair growth treatment or hair support treatment. Yes, it is possible. For example, the delivery of specific fluids and / or other materials to a target skin surface, or the peeling process. Alternatively, the use of polishing processes, the transport of light (e.g., infrared light, ultraviolet light, etc.), the use of lasers, and other Energy-based methods can be used to supplement hair transplantation or hair grafting procedures. It is possible to use various techniques or variations thereof described (or referenced herein) in this specification. This can further improve the likelihood of success in hair transplantation or hair grafting procedures. For example, selective delivery of growth factors (e.g., particularly to a portion of the target tissue) (In terms of the ability to drive or push growth factors) the health and viability of adjacent or surrounding hair transplants It can be strengthened. Massage / Other Tips Details

[0141] In some embodiments, the target skin surface (for example) is used in conjunction with a hair growth treatment or protocol. Massage or treat the scalp, other areas of skin where hair growth is desired, etc. For example, in some configurations, the scalp or other target skin surface is one or more fluids, drugs The subject is massaged before and / or during the transport of the agent and / or other materials. Massage and / or other vibrations of the scalp or other target skin tissue are performed manually and / or This can be achieved using an apparatus or system. For example, several implementations In this context, massage of skin tissue is (for example, as disclosed herein as shown in Figures 1 to 15) Achieve this using a handpiece assembly (similar to one of the assemblies shown) This can be done. In some embodiments, a massage tip (e.g., a handpiece assembly) is used. The distal end of the bri (or a tip that is removable or permanently attached to the tip) is required It can be used to induce the desired or required massage or vibration action. Yes, it is possible. For example, when the tip is moved against adjacent skin tissue, it massages that skin tissue. Includes one or more wavy parts or other features (e.g., recesses, protrusions, etc.) that can be distorted. This can be done. Such massage movements, in conjunction with polishing, can be performed as requested or as needed. Alternatively, this can be achieved instead of polishing. In some embodiments, the skin tissue is polished. Surgery can offer one or more therapeutic benefits related to hair growth. Massage is It can promote the stimulation of specific anatomical responses that may support hair growth. So, massage involves using any therapeutic fluid or other material on the scalp or other target tissues. It can facilitate driving or moving into deeper areas.

[0142] In other embodiments, the tip or other of a handpiece assembly used in hair growth treatments. The distal portion shall contain one or more desired materials in its structure or internally. This is possible. As will be described in more detail herein, the chip or other of the skin treatment system. Strategically embedding one or more materials into one or more surfaces or areas of a part or component, including They can be immersed, arranged, stored and / or deployed. Such materials are solid, semi-solid. It may also contain other dry substances, gels, concentrated solutions, etc. For example, such materials may be Tablets, capsules, pills, or discs embedded in foam pads or other sponge-like materials. Or as other soluble solids, in loose form (e.g., on the chip, in the recess of the chip) or placed in another part, or in a cartridge or other container, or one or more It can be supplied (by bonding it to the surface, etc.). Therefore, in certain configurations, the chip The water being transported (e.g., distilled water, tap water, filtered water, etc.), physiological saline, other diluents and / Or other fluids can be used in skin treatment systems (e.g., handpiece assemblies, handpieces). In cartridges or other containers (such as upstream fluid lines in the assembly) and / or other On or within a part or component thereof, embedded, impregnated and / or placed in the chip The material can be selectively dissolved, liquefied, melted, softened, diluted, or prepared. If desired or necessary, any desired hair growth material or hair growth product can be applied to the skin surface to be treated. This allows for a favorable supply of the agent. Such materials are not limited to the following, but include: It may contain one or more of the following materials: growth factors (e.g., human-derived growth factors, non-human growth factors) Growth factors derived from tungsten, chemically altered growth by liposomes (guide("courier")) Factors, etc.), amino acids (e.g., leucine, isoleucine, valine, etc.), antioxidants, minoxidil Sigil, other antihypertensive vasodilators, finasteride, dutasteride, ketoconazole Lu, spironolactone, flutamide, catechin, epicatechin, other phytochemicals, cal Nitrine, Rejuvaplex, copper peptide, other hair growth stimulants, other medical Pharmaceuticals and non-pharmaceuticals, plant-derived products, cleansing shampoos or pre-cleansing shampoos Shampoo, other cleansing solutions or pre-cleansing solutions (e.g., salicylic acid, glycerin) GlySal ("Glycolic Acid" (trademark) (a mixture of glycolic acid and salicylic acid), other acids, etc.), as well as other natural and synthetic materials.

[0143] According to some embodiments, skin tissue is treated (for example, by hand) using one or more therapeutic materials. Using light tapping, one or more therapeutic materials are applied to the target skin tissue (e.g., scalp). It can be applied to the target tissue. This act of lightly tapping can cause chips or fluids to be applied to the target tissue. Contact and / or movement with other dispensing parts of the container (e.g., bottle, vial, etc.) This can be achieved by the following: In other embodiments, skin assembly may be used as desired or as needed. Applicators (e.g., cotton swabs, cloths, other porous or absorbent materials, etc.) for conveying fluid to the weave. It may be used. However, it is not limited to fluids and / or other therapeutic materials. To deliver to the skin surface, sprays, mists, brushes, rollers, and other dispensers Any other apparatus or method, including the above, may also be used. puncture

[0144] In some embodiments, one or more therapeutic fluids and / or other materials are used in skin tissue Needles may be used to facilitate deeper penetration. For example, using needles This creates a pathway within the target skin tissue, allowing growth factors and / or to reach deeper layers of the skin. It can transport other liquids or materials. In this regard, such a configuration is ( For example, near any hair follicle (including any hair follicles brought forth by hair transplantation or grafting procedures). It can also help facilitate the passage of therapeutic fluids and / or other materials into the skin. The use of puncture or similar procedures to assist the passage of body and / or other materials is requested or It can be used alone or with one or more other techniques as needed (e.g., polishing, stripping, energy transfer). It can be used in conjunction with lasers, phototherapy, pulsed therapy, other mechanical vibrations, heat therapy, etc. Yes, it is possible. For example, the puncture is the same as that described herein with reference to Figures 4A to 4E. This may involve the use of a similar reciprocating needle assembly. Further details regarding puncture can be found here. Filing on March 12, 2014, and international publication number WO201 on September 25, 2014. International patent application PCT / US2014 / 02499, published as 4 / 151104. It is described in Section 2, which is incorporated herein by reference in its entirety.

[0145] Regarding the embodiment of the puncture, the puncture process is configured to promote hair growth or hair stability. Used before and / or after the transport of growth factors and / or other fluids or materials. It can be used to penetrate the skin at least partially. The needle or other component used may contain one or more therapeutic fluids and / or other materials (e.g., A coated needle can be coated and / or configured to include a long factor. For specific uses or applications, the material can be made solid or hollow as requested or as needed. For example, such factors and / or other materials can be on one or more surfaces of the needle (e.g., It can be positioned along the exposed surface. In other embodiments, the corresponding handpiece can be positioned along the exposed surface. Swertia or other internal cavities of a device or system (e.g., inside the needle, along the needle) Various treatment materials can be placed along the recesses (or other recesses in the vicinity). In some embodiments, such materials may be solids, semi-solids, gels, granules and / or It can be provided on or near the needle in other non-liquid forms. various on, near, and / or along the needle or similar component The material is configured to dissolve at least partially in order to be released onto the target skin surface. This can be achieved. By using this embodiment, growth factors and / Alternatively, to further improve the transport of other materials and promote hair growth and / or hair strengthening. It is possible.

[0146] In other embodiments, fluids and / or other therapeutic materials (e.g., growth factors) are transported. The needle is at least partially hollow so that it can be used. This allows for the precise delivery of growth factors and / or other factors to the surface and / or interior of the target skin tissue. It can support the efficient and selective transport of materials. For example, in some configurations The hollow portion of the needle is in fluid communication with the reservoir, and is used for specific applications, protocols, or treatment procedures. Therefore, the user can transport one or more fluids and / or other materials at a desired flow rate. can.

[0147] Any embodiment of the needle or any alternative embodiment described herein may be part of a therapeutic procedure. The needles used can be covered with one or more therapeutic materials. As mentioned above, The materials may include, but are not limited to, one or more of the following materials: Growth factors (e.g., human-derived growth factors, non-human-derived growth factors, liposomes (guide("cour Chemically modified growth factors (such as those produced by ier), amino acids (e.g., leucine, i) (Soloisin, valine, etc.), antioxidants, minoxidil, other antihypertensive vasodilators, finasteride Teride, dutasteride, ketoconazole, spironolactone, flutamide, catechin Epicatechin, other phytochemicals, carnitine, Rejuvaplex ``, copper peptides, other hair growth stimulants, other pharmaceuticals and non-pharmaceuticals, plant-derived products, cleansing agents Cleansing shampoo or pre-cleansing shampoo, other cleansing solution or pre Cleansing solution (e.g., salicylic acid, glycal ("GlySal") (trademark) (glycol) Acids and salicylic acid mixtures), other acids, etc., as well as other natural and synthetic materials, etc. Treatment materials such as those used to cover needles, etc. (for example, completely or at least partially) Alternatively, it can be deposited. In some embodiments, such material is water, Gels, solids, and semi-solids that can be dissolved or released in the presence of physiological saline and / or other liquids. It can be provided in and / or other forms. Embodiment of massage / wavy section for increasing injection force

[0148] In some embodiments, the tip or other distal portion of the treatment device or treatment system ( For example, the handpiece assembly or the distal end of the handpiece assembly, or its attachment (Items that are fixed in close proximity) do not necessarily abrade the skin tissue, but rather polish the skin tissue they come into contact with. It is configured to surge or handle. For example, in some embodiments, The tip or other distal part of the handpiece assembly should not be in contact with the skin surface. When operating Swertia or other devices or systems (for example, whether or not polishing or stripping is performed) Regardless of the configuration, one or more nonlinear or wave-like structures are configured to impart mechanical vibrations. It may include parts and / or structures. In some embodiments, such mat One or more structures and / or other configurations that cause surge or pressure open pores. This helps to penetrate the skin or to facilitate the arrival of therapeutic materials into deeper layers of the skin. , the treatment material is to penetrate deeper into the skin tissue (for example, closer to the hair follicles, and also deeper into the skin tissue) "Drive" or move (to get closer to the deeper parts) to stimulate hair growth / stimulate the scalp or skin This can further promote health and other related conditions, thereby improving treatment procedures. Scalp health / Other comments

[0149] In some embodiments, the same or similar treatment as described herein, or The equivalent treatment is used to treat other diseases or conditions relating to the skin or hair. This can be done. For example, in some embodiments, such treatment is performed on the scalp or To improve the health of other skin surfaces and the condition of subjects with dandruff, psoriasis, seborrheic dermatitis, etc. It can be used to promote treatment or improvement.

[0150] This assists in describing the disclosed embodiments. Up, top, bottom, down, lower, rear, front, hanging The terms straight, horizontal, upstream, and downstream are used to describe various embodiments and / or accompanying drawings. For this purpose, it was used above. However, various implementations, whether illustrated or not, It will be understood that the form can be positioned and oriented to various desired locations.

[0151] While several embodiments and examples have been disclosed herein, this application specifically discloses... Beyond these embodiments, other alternative embodiments and / or uses of the present invention, as well as their applications, are described. This extends to improvements and equivalents of these. Various combinations of specific features and embodiments of this embodiment. Combinations or partial combinations may be made, and they remain within the scope of the present invention. It is also considered that they may be included. Therefore, various features and aspects of the disclosed embodiments are disclosed. To modify the aspects of the invention, combine them with each other or substitute them with each other. It should be understood that there is a limit to the scope of the invention disclosed herein. The claims below should not be limited by the specific embodiments described herein, but rather should be limited to the following claims. It is intended that this should only be determined by a fair reading of it.

[0152] While various improved and alternative forms are possible for this invention, specific examples thereof are not provided. As shown in the drawings and described in detail herein, however, the present invention may not be limited to any particular embodiment disclosed. The present invention is not limited to the methods described, but rather extends to the various embodiments and accessories described. All improvements, equivalents, and substitutes that fall within the spirit and scope of the attached claims are included in this patent claim. It should be understood that this is a matter of enumeration. Any method disclosed herein is in the order listed. It is not necessary to implement this. The method summarized above and described in more detail below is what the implementer should do. This describes several actions, but may also include instructions for actions by another party. It should be understood. The method summarized above and explained in more detail below is for the user (example). For example, it describes specific actions taken by a specialist (in some cases), but does not describe instructions for actions taken by another party. It should be understood that this can also include "to move the handpiece". Actions such as "transporting fluid" are equivalent to "instructing the handpiece to move" and "flow This includes the act of "instructing the transport of the body." The scope disclosed herein is arbitrary and This includes all overlapping ranges, subranges, and combinations thereof. ("Up to," "At least") Words such as "greater than," "less than," and "between" include the numbers listed. The numbers following terms such as "approximately" include the numbers listed. For example, "approximately 10mm" Includes "10mm". Terms or phrases following terms such as "substantially" are the same as the listed terms or The word includes the phrase. For example, "effectively parallel" includes "parallel".

Claims

1. A method for promoting hair growth or hair stimulation in a subject, Using a handpiece assembly, vacuum or suction is applied along the target area of ​​the skin surface of the subject for whom hair growth or hair stimulation is desired. This includes supplying at least one therapeutic material to the target portion of the skin surface of the subject, A method for promoting hair growth or stimulating hair by applying the aforementioned vacuum or suction.

2. The method according to claim 1, wherein the vacuum or suction is applied continuously or intermittently.

3. The method according to claim 2, wherein the vacuum or suction is applied intermittently using a pulse device.

4. The method according to claim 1, wherein supplying at least one therapeutic material to the skin of the subject is achieved (i) manually by applying or tapping with the hands, or (ii) via a handpiece assembly.

5. The method according to claim 3, wherein the pulse device is configured to alternately generate a first pressure and a second pressure along the skin surface of the subject, the first pressure being greater than the second pressure, and the second pressure being a vacuum or suction.

6. The method according to claim 5, wherein the first pressure is positive pressure.

7. The method according to claim 5, wherein the first pressure is a vacuum or suction.

8. The method according to any one of claims 1 to 7, wherein the distal end of the handpiece assembly is configured to contact the skin surface of the subject.

9. The method according to claim 8, wherein the distal end of the handpiece assembly is provided with a tip.

10. The method according to claim 9, wherein the tip is removable from the proximal portion of the handpiece assembly.

11. The method according to claim 9, wherein the tip comprises at least one suction port or opening to which vacuum or suction is selectively applied.

12. The method according to any one of claims 1 to 11, wherein the at least one therapeutic material comprises one or more of the following: growth factors, amino acids (e.g., leucine, isoleucine, valine, etc.), antioxidants, minoxidil, other antihypertensive vasodilators, finasteride, dutasteride, ketoconazole, spironolactone, flutamide, catechin, epicatechin, other phytochemicals, carnitine, Rejuvaplex ("rejuvaplex"), copper peptides, other hair growth stimulants, other pharmaceuticals and non-pharmaceuticals, plant-derived products, cleansing shampoos or pre-cleansing shampoos, other cleansing solutions or pre-cleansing solutions (e.g., salicylic acid, GlySal ("Glycolic Acid and Salicylic Acid Mixture"), other acids, etc.), and other natural and synthetic materials.

13. The method according to any one of claims 1 to 12, wherein the at least one treatment material is contained in a bottle, and the bottle is in fluid communication with the handpiece assembly.

14. The method according to any one of claims 1 to 12, wherein the at least one treatment material is housed in a cartridge and the cartridge is configured to be fixed to the handpiece assembly.

15. The method according to any one of claims 1 to 14, wherein the at least one treatment material is placed on the tip of the handpiece assembly, and the at least one treatment material is configured to dissolve or release at least partially in the presence of a liquid.

16. The method according to any one of claims 1 to 15, wherein applying the vacuum or suction promotes increased blood flow to or near the target portion of the skin surface of the subject.

17. The method according to any one of claims 1 to 16, further comprising at least partially peeling off the skin surface of the subject.

18. The method according to claim 17, wherein at least partially peeling off the skin surface of the subject includes peeling using an abrasive surface or abrasive member.

19. The method according to claim 17 or 18, wherein at least partially peeling off the skin surface of the subject includes peeling using a chemical peeling agent.

20. The method according to any one of claims 17 to 19, wherein at least a portion of the subject's skin surface is peeled off before supplying at least one therapeutic material to the target portion of the subject's skin surface.

21. The method according to claim 20, wherein the at least one therapeutic material comprises a growth factor.

22. The method according to any one of claims 17 to 21, further comprising applying phototherapy to the skin tissue, wherein the phototherapy includes applying red light or blue light to the skin tissue.

23. A step of massaging the skin surface, wherein the massage is performed manually or using a massage tip. The steps include heating or cooling the skin surface, The steps include irradiating the skin surface with light, The process of puncturing the skin surface, The steps include supplying pulsed air to the skin surface, The steps include supplying vacuum and / or positive pressure to the skin surface, The process further includes one or more additional steps from the step of polishing the skin surface, The method according to any one of claims 1 to 22, wherein the one or more additional steps are performed before, during, and / or after supplying at least one therapeutic material to the target portion of the skin surface of the subject.

24. The method according to claim 22, wherein the phototherapy is used to activate the at least one therapeutic material to promote hair growth or stimulate hair.

25. The method according to any one of claims 1 to 24, further comprising at least partially penetrating the skin surface of the subject.

26. The method according to claim 25, wherein at least partially penetrating the skin surface of the subject comprises using at least one needle assembly configured to selectively penetrate skin tissue.

27. The method according to claim 26, wherein the at least one needle assembly is configured to open a passage in the skin of the subject, the passage leading to a hair follicle of the subject or near the hair follicle.

28. The method according to claim 26, wherein the at least one needle assembly is covered with or comprises at least one therapeutic material.

29. The method according to claim 26, wherein the at least one needle assembly comprises a plurality of hollow needles, and at least one therapeutic material is configured to be transported through the passages of the hollow needles.

30. The method according to any one of claims 1 to 29, further comprising massaging or vibrating the target portion of the subject's skin surface to facilitate the delivery of the at least one therapeutic material to deeper layers of the skin surface.

31. The method according to claim 30, wherein the massaging or vibrating results in opening pores at least partially along the surface of the subject's skin to facilitate the passage of the at least one therapeutic material.

32. The method according to claim 30, wherein the massaging or vibrating comprises moving a handpiece having at least one nonlinear surface relative to the skin surface.

33. The method according to claim 32, wherein the at least one nonlinear structure comprises a wavy but smooth surface or structure.

34. The method according to any one of claims 1 to 33, further comprising performing the procedure on or near the portion of skin tissue that has been transplanted.

35. The method according to any one of claims 1 to 34, further comprising transplanting at least a number of hair follicles to or near the portion of skin tissue to be treated.

36. The method according to any one of claims 1 to 35, further comprising heating or cooling the target portion of the skin surface of the subject to be treated.

37. The method according to claim 36, wherein heating or cooling the skin surface includes using a separate thermoregulator.

38. The method according to claim 37, wherein the separate thermal control element comprises an element consisting of a thermoelectric element or a Peltier element.

39. The method according to any one of claims 1 to 38, further comprising supplying energy to the target portion of the skin surface of the subject in order to enhance hair growth or hair stimulation.

40. The method according to claim 39, wherein the energy supplied to the skin tissue includes one or more of radio frequency (RF) energy, microwave energy, ultrasonic energy, iontophotoresis, and laser.

41. A method for promoting hair growth or hair stimulation in a subject, The handpiece assembly is used to apply positive pressure along the target area of ​​the skin surface of the subject for whom hair growth or hair stimulation is desired, This includes supplying at least one therapeutic material to the target portion of the skin surface of the subject, The method of applying the aforementioned positive pressure to promote hair growth or stimulate hair growth.

42. The method according to claim 41, wherein the positive pressure applied to the skin surface of the subject facilitates the passage of the at least one therapeutic material into the subject's skin.

43. The method according to claim 41 or 42, wherein the positive pressure is applied continuously.

44. The method according to claim 41 or 42, wherein the positive pressure is applied intermittently.

45. The method according to claim 44, wherein the positive pressure is applied intermittently using a pulse device.

46. The method according to claim 44 or 45, wherein the distal end of the handpiece assembly is configured to contact the skin surface of the subject.

47. The method according to claim 46, wherein the distal end of the handpiece assembly is provided with a tip.

48. The method according to claim 47, wherein the tip is removable from the proximal portion of the handpiece assembly.

49. The method according to claim 47, wherein the tip comprises at least one suction port or opening to which positive pressure is selectively applied.

50. The method according to any one of claims 41 to 49, wherein the at least one therapeutic material comprises one or more of the following: growth factors, amino acids (e.g., leucine, isoleucine, valine, etc.), antioxidants, minoxidil, other antihypertensive vasodilators, finasteride, dutasteride, ketoconazole, spironolactone, flutamide, catechin, epicatechin, other phytochemicals, carnitine, rejuvaplex, copper peptides, other hair growth stimulants, other pharmaceuticals and non-pharmaceuticals, plant-derived products, and other natural and synthetic materials.

51. The method according to any one of claims 41 to 50, wherein the at least one treatment material is contained in a bottle, and the bottle is in fluid communication with the handpiece assembly.

52. The method according to any one of claims 41 to 50, wherein the at least one treatment material is housed in a cartridge, and the cartridge is configured to be fixed to the handpiece assembly.

53. The method according to any one of claims 41 to 52, wherein the at least one treatment material is placed on the tip of the handpiece assembly, and the at least one treatment material is configured to dissolve or be released at least partially in the presence of a liquid.

54. The method according to any one of claims 41 to 53, wherein applying the positive pressure promotes blood flow to the target portion or near the target portion of the skin surface of the subject.

55. The method according to any one of claims 41 to 54, further comprising at least partially peeling off the skin surface of the subject.

56. The method according to claim 55, wherein at least partially peeling off the skin surface of the subject includes peeling using an abrasive surface or abrasive member.

57. The method according to claim 55 or 56, wherein the removal of at least a portion of the skin surface of the subject is performed by using a chemical stripping agent.

58. The method according to any one of claims 55 to 57, wherein at least partially peeling off the skin surface of the subject is performed before supplying at least one therapeutic material to the target portion of the skin surface of the subject.

59. The method according to claim 58, wherein the at least one therapeutic material comprises a growth factor.

60. The method according to any one of claims 55 to 59, further comprising applying phototherapy to the skin tissue.

61. The method according to claim 60, wherein the phototherapy comprises applying red light or blue light to the skin tissue.

62. The method according to claim 60 or 61, wherein the phototherapy is used to activate the at least one therapeutic material to promote hair growth or to stimulate hair.

63. The method according to any one of claims 41 to 62, further comprising at least partially penetrating the skin surface of the subject.

64. The method according to claim 63, wherein at least partially penetrating the skin surface of the subject comprises using at least one needle assembly configured to selectively penetrate skin tissue.

65. The method according to claim 64, wherein the at least one needle assembly is configured to open a passage in the subject's skin, the passage leading to the subject's hair follicle or the vicinity of the hair follicle.

66. The method according to claim 64, wherein the at least one needle assembly is covered with or comprises at least one therapeutic material.

67. The method according to claim 64, wherein the at least one needle assembly comprises a plurality of hollow needles, and at least one therapeutic material is configured to be transported through the passages of the hollow needles.

68. The method according to any one of claims 41 to 67, further comprising massaging or vibrating the target portion of the subject's skin surface to facilitate the delivery of the at least one therapeutic material to deeper layers of the skin surface.

69. The method according to claim 68, wherein the massaging or vibrating results in opening pores at least partially along the surface of the subject's skin to facilitate the passage of the at least one therapeutic material.

70. The method according to claim 68, wherein the massaging or vibrating comprises moving a handpiece having at least one nonlinear surface relative to the skin surface.

71. The method according to claim 70, wherein the at least one nonlinear structure includes a wavy but smooth surface or structure.

72. The method according to any one of claims 41 to 71, further comprising performing the procedure on or near the portion of skin tissue that has been transplanted.

73. The method according to any one of claims 41 to 72, further comprising transplanting at least a number of hair follicles to or near the portion of skin tissue to be treated.

74. The method according to any one of claims 41 to 73, further comprising heating or cooling the target portion of the skin surface of the subject to be treated.

75. The method according to claim 74, wherein heating or cooling the skin surface includes using a separate thermoregulator.

76. The method according to claim 75, wherein the separate thermal control element comprises an element consisting of a thermoelectric element or a Peltier element.

77. The method according to any one of claims 41 to 76, further comprising supplying energy to the target portion of the skin surface of the subject in order to enhance hair growth or hair stimulation.

78. The method according to claim 77, wherein the energy supplied to the skin tissue includes one or more of radio frequency (RF) energy, microwave energy, ultrasonic energy, iontophoresis, and laser.

79. The method according to any one of claims 1 to 78, wherein the method is configured to be useful for one or more of the following conditions of skin or hair: dandruff, psoriasis, seborrheic dermatitis and any other condition of skin or hair.

80. An engaging member configured to be positioned along the distal end of the handpiece assembly, A proximal end configured to be attached to the proximal component of the handpiece assembly, A distal end configured to contact and engage with the skin surface to be treated, A body extending between the proximal end and the distal end, configured to adapt to the irregularities and other shapes along the skin surface to be treated, The aforementioned engaging member is flexible, The engaging member is configured to facilitate the capture of fluids present along the skin surface being treated during use.

81. The engaging member according to claim 80, wherein the engaging member comprises rubber or other elastomer material.

82. The engaging member according to claim 81, wherein the rubber includes silicone rubber.

83. The engaging member according to any one of claims 80 to 82, wherein the engaging member comprises at least one bellows or other foldable member to facilitate the operation of the engaging member against the skin surface to be treated.

84. The engaging member according to any one of claims 80 to 83, wherein the engaging member is configured to be coupled to the tip of the handpiece assembly, and the proximal end of the engaging member is configured to be fixedly or detachably coupled to the tip.

85. The engaging member according to any one of claims 80 to 83, wherein the engaging member is configured to be coupled to the main body portion of the handpiece assembly, and the proximal end of the engaging member is configured to be fixedly or detachably coupled to the main body of the handpiece assembly.

86. A tip configured to be positioned along the distal end of a handpiece assembly for a skin treatment or hair growth treatment, comprising the engaging member described in any one of claims 80 to 85.

87. A handpiece assembly for a skin treatment or hair growth treatment, comprising an engaging member according to any one of claims 80 to 85.

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