Composition for direct compression, pharmaceutical composition, tablets, single-layer tablets, and method for manufacturing tablets.

The combination of cellulose derivatives and polyhydric phenol compounds addresses issues of sustained release and tablet hardness in direct compression, resulting in tablets with enhanced hardness and sustained-release capabilities.

JP2026061747APending Publication Date: 2026-04-09MITSUBISHI CHEM CORP
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Filing Date
2024-09-30
Publication Date
2026-04-09

AI Technical Summary

Technical Problem

Conventional formulations using cellulose derivatives for direct compression suffer from insufficient sustained release, tablet hardness, and capping due to low fluidity and compressibility, as well as inadequate swelling when water penetrates the tablet.

Method used

A composition comprising cellulose derivatives and polyhydric phenol compounds with specific structures, such as tannic acid, is used to enhance tablet hardness and sustained-release properties through hydrogen bonding and gel formation.

Benefits of technology

The composition achieves tablets with excellent sustained-release properties, high tablet hardness, and improved moldability, ensuring uniform matrix formation and effective drug encapsulation.

✦ Generated by Eureka AI based on patent content.

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Abstract

The objective is to provide compositions and the like for manufacturing tablets with excellent sustained-release properties, high tablet hardness, and excellent tablet moldability by direct compression. [Solution] The present invention relates to a direct-compression tablet composition containing (A) a cellulose derivative and (B) a polyhydric phenol compound having 1 to 20 structures in the molecule having two or more hydroxyl groups directly attached to an aromatic ring. The present invention also relates to a pharmaceutical composition containing (A) a cellulose derivative, (B) a polyhydric phenol compound having 1 to 20 structures in the molecule having two or more hydroxyl groups directly attached to an aromatic ring, and (C) a pharmaceutically active ingredient, wherein the mass-based ratio of the content of the pharmaceutically active ingredient (C) to the content of the cellulose derivative (A) and the polyhydric phenol compound (B) is 0.01 to 10, and the mass-based ratio of the content of the cellulose derivative (A) to the content of the polyhydric phenol (B) is 60 / 40 to 99 / 1.
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Citation Information

Patent Citations

  • Compositions and formulations for delayed gastric release of alendronate and / or other bisphosphonates

    JP2004501186A

  • Gastric retention tablets

    JP6823539B2