Individually packaged liquid cleaning agent for hard surfaces, and cleaning method using the individually packaged liquid cleaning agent for hard surfaces.

Abstract

The present invention aims to provide a liquid cleaning agent in individual packaging for hard surfaces that is excellent in cleaning performance on hard surfaces of objects to be cleaned, and in the long-term stability of enzymes contained in the cleaning agent, as well as being simple and convenient to use, and a method for cleaning hard surfaces of objects using the same. [Solution] A liquid cleaning agent for hard surfaces containing (A) a nonionic surfactant, (B) an ionic surfactant, (C) an enzyme, and (D) a solvent in specific ratios is sealed in a container made of water-soluble film.

Description

[Technical Field]

[0001] The present invention relates to a liquid cleaning agent for hard surfaces in individual packaging, and a cleaning method using the liquid cleaning agent for hard surfaces in individual packaging. [Background technology]

[0002] Used medical instruments such as scalpels, forceps, and syringes in hospitals and other medical facilities are cleaned and recycled whenever possible. These medical instruments are made of hard materials such as metal, plastic, rubber, glass, and ceramics. The contaminants that adhere to these instruments during examinations and treatments include blood, lymph, and tissue fluid, which are mainly composed of proteins. Therefore, incorporating proteases, which are protein-degrading enzymes, has been considered an effective way to efficiently remove these stains. However, when cleaning agents containing enzymes are stored for a long period of time, the enzymes lose their stability, resulting in insufficient removal of stains composed of proteins and other substances.

[0003] Patent Document 1 discloses a liquid cleaning agent composition for hard surfaces comprising 0.1 to 5% by mass of a specific nonionic surfactant having a cloud point of 20°C or less, 0.5 to 10% by mass of a specific nonionic surfactant having a cloud point of 35°C or less, 10 to 30% by mass of an alkanolamine, 0.1 to 7% by mass of an enzyme, 7.5 to 22.5% by mass of an n-hexyl glycoside, a calcium additive, and water.

[0004] Patent Document 2 discloses a liquid detergent composition containing at least one selected from the group consisting of aromatic sulfonic acid or a salt thereof, thiosulfate or a salt thereof, and sulfite or a salt thereof, a polyhydric alcohol, amylase, protease, and water, wherein the mass ratio of at least one selected from the group consisting of aromatic sulfonic acid or a salt thereof, thiosulfate or a salt thereof, and sulfite or a salt thereof is 4 or more and 1000 or less, and the pH at 25°C is 6 or more and 8 or less.

[0005] However, in both Patent Documents 1 and 2, due to the autolysis of enzymes, particularly proteases, in the detergent composition, the storage stability and enzyme activity stability of the detergent composition are insufficient, and further improvement is required.

Prior Art Documents

Patent Documents

[0006]

Patent Document 1

Patent Document 2

Summary of the Invention

Problems to be Solved by the Invention

[0007] An object of the present invention is to provide a single-packaged liquid detergent for hard surfaces that is excellent in the detergency of the hard surface of a cleaning target and the long-term stability of enzymes contained in the detergent, and has high simplicity and convenience, and a method for cleaning the hard surface of a cleaning target using the same.

Means for Solving the Problems

[0008] As a result of intensive studies, the present inventors have found that a single-packaged liquid detergent for hard surfaces, which comprises a liquid detergent composition for hard surfaces containing (A) a nonionic surfactant, (B) an ionic surfactant, and (C) an enzyme in specific ratios, encapsulated in a water-soluble film container, solves the above problems. That is, the present invention is characterized by the following points. That is, the present invention is characterized as follows. [1] A single-packaged liquid detergent for hard surfaces, wherein the liquid detergent for hard surfaces is encapsulated in a water-soluble film container, when the single-packaged liquid detergent for hard surfaces is thrown into a cleaning bath, the water-soluble film container dissolves in water, and the liquid detergent for hard surfaces as the content is released into the cleaning bath. The amount of the liquid cleaning agent for hard surfaces enclosed is 5 to 50 g. The liquid cleaning agent for hard surfaces consists of a liquid cleaning agent composition for hard surfaces. The liquid cleaning agent composition for hard surfaces contains (A) a nonionic surfactant, (B) an ionic surfactant, (C) an enzyme, and (D) a solvent. (B) The ionic surfactant comprises at least one selected from the group consisting of anionic surfactants, cationic surfactants, and amphoteric surfactants. (D) The solvent contains water, or contains water and an aqueous organic solvent. The composition of the liquid cleaning agent for hard surfaces contains (A) 10-90% by mass of nonionic surfactant, (B) 0.1-30% by mass of ionic surfactant, (C) 0.01-20% by mass of enzyme, (D) 5-88% by mass of solvent, and 0.01-20% by mass of water. The mass ratio of (A) nonionic surfactant to (B) ionic surfactant is between 2 / 1 and 200 / 1. Individually packaged liquid cleaning agent for hard surfaces. [2] The liquid cleaning agent for hard surfaces described in [1] above, wherein the composition of the liquid cleaning agent for hard surfaces contains (A) 10 to 50% by mass of nonionic surfactant, (B) 0.1 to 25% by mass of ionic surfactant, (C) 0.01 to 20% by mass of enzyme, (D) 5 to 88% by mass of solvent, and 0.01 to 20% by mass of water, and the mass ratio of (A) nonionic surfactant to (B) ionic surfactant is 2 / 1 to 200 / 1. [3](A) A liquid cleaning agent package for hard surfaces according to [1] above, wherein the nonionic surfactant comprises at least one selected from the group consisting of compounds represented by general formula (1) and general formula (2). [ka] (In the formula, R 1 R is a linear alkyl or alkenyl group having 8 to 24 carbon atoms, or a branched alkyl or alkenyl group having 8 to 24 carbon atoms. 2is a hydrogen atom, a linear alkyl or alkenyl group having 2 to 18 carbon atoms, or a branched alkyl or alkenyl group having 2 to 18 carbon atoms, and A 1 O is an alkyleneoxy group having 2 to 4 carbon atoms, and n is the average number of repeating units of A 1 O and is a number from 1 to 30.) [Chemical formula] (In the formula, R 3 is a linear alkyl or alkenyl group having 6 to 24 carbon atoms, or a branched alkyl or alkenyl group having 6 to 24 carbon atoms, and A 2 O and A 3 O are each independently an alkyleneoxy group having 2 to 4 carbon atoms, and each of p and q is the average number of repeating units of A 2 O and A 3 O, and are each independently a number greater than or equal to 0, and p + q = 1 to 50.) [4] The anionic surfactant-containing ionic surfactant contains The anionic surfactant contains at least one selected from the group consisting of alkyl sulfonates, alkyl sulfate esters, and carboxylates<A The single-packaged liquid detergent for hard surfaces according to [1] above [5] The single-packaged liquid detergent for hard surfaces according to [1] above, wherein the hard surface is a hard surface of a medical device [6] The single-packaged liquid detergent for hard surfaces according to [1] above, wherein the water-soluble film is a water-soluble film made of polyvinyl alcohol [7] A method for cleaning a hard surface using the single-packaged liquid detergent for hard surfaces according to any one of [1] to [6] above [Effect of the Invention]

[0009] According to the present invention, it is possible to obtain a liquid cleaning agent for hard surfaces that is excellent in cleaning performance on hard surfaces of objects to be cleaned and in the long-term stability of the enzymes contained in the cleaning agent, as well as a simple and convenient individual packaging, and a method for cleaning hard surfaces of objects using the liquid cleaning agent for hard surfaces individual packaging. Furthermore, by adjusting the content of each component, such as increasing the content of (D) solvent and decreasing the content of (A) nonionic surfactant and (B) ionic surfactant in the liquid cleaning agent composition for hard surfaces, it is possible to obtain individually packaged liquid cleaning agents for hard surfaces that also have excellent spreadability in a cleaning bath, and a method for cleaning the hard surface of an object to be cleaned using said individually packaged liquid cleaning agents for hard surfaces. "Excellent dispersibility into the cleaning bath" means that the liquid cleaning agent composition, which is the contents of the individual packaging of the liquid cleaning agent for hard surfaces, dissolves quickly and uniformly in the cleaning bath. [Modes for carrying out the invention]

[0010] The embodiments of the present invention will be described in detail below. The description of the constituent elements described below is an example of an embodiment of the present invention, and the present invention is not limited to these contents unless it exceeds the gist of the invention.

[0011] <Individually packaged liquid cleaning agent for hard surfaces> The present invention provides individually packaged liquid cleaning agents for hard surfaces, in which a liquid cleaning agent for hard surfaces, consisting of a liquid cleaning agent composition for hard surfaces, is sealed in small quantities in containers made of water-soluble film and individually packaged. When cleaning an object to be cleaned, depending on the amount of the object to be cleaned and the amount of the cleaning bath, at least one individual package of the hard surface liquid cleaning agent of the present invention can be added to the cleaning bath, or the individual package of the hard surface liquid cleaning agent can be torn open and the contents of the hard surface liquid cleaning agent released into the cleaning bath and dissolved. When the individual packets of the hard surface liquid cleaning agent are thrown into the cleaning bath, the water-soluble film container dissolves in the cleaning bath, and the contents of the hard surface liquid cleaning agent are released and dissolved in the cleaning bath.

[0012] Because the individual packaging of the liquid cleaning agent for hard surfaces is in small quantities, unused individual packaging can suppress deterioration such as oxidation of the contents of the liquid cleaning agent for hard surfaces due to contact with air, and the enzyme activity stability and long-term storage of the liquid cleaning agent for hard surfaces can be improved. There are no particular restrictions on the amount of liquid cleaning agent for hard surfaces contained in one individual package of the liquid cleaning agent for hard surfaces, but 5 to 50 g is preferred, and 8 to 15 g is more preferred.

[0013] <Liquid cleaning agent for hard surfaces> The liquid cleaning agent for hard surfaces in the present invention is a liquid cleaning agent comprising the liquid cleaning agent composition for hard surfaces in the present invention.

[0014] <Liquid cleaning agent composition for hard surfaces> The liquid cleaning agent composition for hard surfaces in the present invention contains (A) a nonionic surfactant, (B) an ionic surfactant, (C) an enzyme, and (D) a solvent, and may further contain (E) an additive as needed. (B) The ionic surfactant preferably includes at least one selected from the group consisting of anionic surfactants, cationic surfactants, and amphoteric surfactants. Furthermore, the liquid cleaning agent composition for hard surfaces in the present invention may, as necessary, contain components other than those mentioned above, as long as they do not impair the effects of the present invention.

[0015] The content of (A) nonionic surfactant in the liquid cleaning agent composition for hard surfaces is preferably 10 to 90% by mass, more preferably 30 to 80% by mass, and even more preferably 50 to 70% by mass, in order to obtain excellent cleaning performance. The content of (B) ionic surfactant in the liquid cleaning agent composition for hard surfaces is preferably 0.1 to 30% by mass, more preferably 4.5 to 30% by mass, and even more preferably 15 to 30% by mass, in order to obtain excellent cleaning performance. The content of (C) enzyme in the liquid cleaning agent composition for hard surfaces is preferably 0.01 to 20% by mass, more preferably 0.1 to 10% by mass, and even more preferably 0.2 to 5% by mass, in order to obtain excellent cleaning performance. The content of solvent (D) in the hard surface liquid cleaning agent composition is preferably 5 to 88% by mass, more preferably 5 to 60% by mass, and even more preferably 5 to 50% by mass, in order to obtain excellent cleaning performance and long-term storage of the hard surface liquid cleaning agent individual packaging. Furthermore, if the liquid cleaning agent composition for hard surfaces contains additive (E), the content of additive (E) in the liquid cleaning agent composition for hard surfaces is preferably 0.01 to 5% by mass, and more preferably 0.01 to 3% by mass, in order to obtain excellent cleaning performance. The mass ratio of (A) nonionic surfactant to (B) ionic surfactant is preferably 2 / 1 to 200 / 1, more preferably 2 / 1 to 150 / 1, and even more preferably 2 / 1 to 130 / 1, in order to obtain excellent cleaning performance. The liquid cleaning agent composition for hard surfaces can have excellent cleaning properties if the content of (A) nonionic surfactant, (B) ionic surfactant, (C) enzyme, (D) solvent, and (E) additive in the composition is within the above range.

[0016] Furthermore, in order to obtain excellent dispersibility in the cleaning bath, it is preferable to increase the content of (D) solvent to make it easier for (A) nonionic surfactants and (B) ionic surfactants to dissolve, and in that case, the following are preferred in the liquid cleaning agent composition for hard surfaces. (A) The content of the nonionic surfactant is preferably 10 to 90% by mass, and more preferably 10 to 50% by mass. (B) The content of the ionic surfactant is preferably 0.1 to 30% by mass, more preferably 0.1 to 25% by mass, even more preferably 0.5 to 25% by mass, and particularly preferably 0.5 to 20% by mass. (C) The enzyme content is preferably 0.01 to 20% by mass, more preferably 0.1 to 10% by mass, and even more preferably 0.2 to 5% by mass. (D) The solvent content is preferably 5 to 88% by mass, more preferably 20 to 80% by mass, and even more preferably 35 to 80% by mass. Furthermore, the mass ratio of (A) nonionic surfactant to (B) ionic surfactant is preferably 2 / 1 to 200 / 1, more preferably 2 / 1 to 150 / 1, and even more preferably 2 / 1 to 130 / 1. If the liquid cleaning agent composition for hard surfaces contains additive (E), the amount of additive (E) is Preferably, the amount is 0.01 to 5% by mass, and more preferably 0.01 to 3% by mass.

[0017] Among the above combinations of content, a preferred combination is one in which (A) nonionic surfactant content is 10-90% by mass, (B) ionic surfactant content is 0.1-30% by mass, (C) enzyme content is 0.01-20% by mass, (D) solvent content is 5-88% by mass, and the mass ratio of (A) nonionic surfactant to (B) ionic surfactant is 2 / 1 to 200 / 1. Furthermore, a combination in which (A) the content of nonionic surfactant is 10 to 50% by mass, (B) the content of ionic surfactant is 0.1 to 25% by mass, (C) the content of enzyme is 0.01 to 20% by mass, (D) the content of solvent is 5 to 88% by mass, and the mass ratio of (A) nonionic surfactant to (B) ionic surfactant is 2 / 1 to 200 / 1 is more preferable. Furthermore, a combination in which (A) the content of nonionic surfactant is 10 to 50% by mass, (B) the content of ionic surfactant is 0.5 to 25% by mass, (C) the content of enzyme is 0.1 to 10% by mass, (D) the content of solvent is 20 to 80% by mass, and the mass ratio of (A) nonionic surfactant to (B) ionic surfactant is 2 / 1 to 150 / 1 is even more preferable. Furthermore, a combination in which (A) the content of nonionic surfactant is 10 to 50% by mass, (B) the content of ionic surfactant is 0.5 to 20% by mass, (C) the content of enzyme is 0.2 to 5% by mass, (D) the content of solvent is 35 to 80% by mass, and the mass ratio of (A) nonionic surfactant to (B) ionic surfactant is 2 / 1 to 130 / 1 is particularly preferred.

[0018] <(A) Nonionic surfactants> (A) Examples of nonionic surfactants include, but are not limited to, polyoxyalkylene alkyl ethers, polyoxyalkylene alkylamines, polyoxyethylene fatty acid esters, alkyl polyglycosides, aliphatic alkanolamides, and polyhydric alcohol esters. These may be used individually or in combination of two or more.

[0019] To obtain excellent cleaning properties, (A) the nonionic surfactant preferably contains at least one selected from polyoxyalkylene alkyl ethers and polyoxyalkylene alkylamines among the above.

[0020] (Polyoxyalkylene alkyl ether) Examples of polyoxyalkylene alkyl ethers include compounds represented by the following general formula (1).

[0021] [ka] (In the formula, R 1 R is a linear alkyl or alkenyl group having 8 to 24 carbon atoms, or a branched alkyl or alkenyl group having 8 to 24 carbon atoms. 2 A is a hydrogen atom, a linear alkyl or alkenyl group having 2 to 18 carbon atoms, or a branched alkyl or alkenyl group having 2 to 18 carbon atoms. 1 O is an alkylene oxy group with 2 to 4 carbon atoms, and n is a repeating unit A. 1 (This is the average number of repetitions of O, and is a number between 1 and 30.)

[0022] In formula (1), R 1 and R 2 In order to obtain excellent cleaning performance, R 1 R is a linear alkyl or alkenyl group having 8 to 18 carbon atoms, or a branched alkyl or alkenyl group having 8 to 18 carbon atoms. 2The group consists of a hydrogen atom, a linear alkyl or alkenyl group having 2 to 6 carbon atoms, or a branched alkyl or alkenyl group having 2 to 6 carbon atoms. It is preferable. Also, A 1 For excellent cleaning properties, O is preferably an alkylene oxy group having 2 to 3 carbon atoms. -(A 1 O) n - Different A 1 The order of the O's may be random or in a block-like pattern. Furthermore, for excellent cleaning performance, n is preferably a number between 4 and 20, and more preferably a number between 6 and 18.

[0023] (Polyoxyalkylene alkylamine) Examples of polyoxyalkylene alkylamines include compounds represented by the following general formula (2).

[0024] [ka] (In the formula, R 3 A is a linear alkyl or alkenyl group having 6 to 24 carbon atoms, or a branched alkyl or alkenyl group having 6 to 24 carbon atoms. 2 O and A 3 O is an alkylene oxy group with 2 to 4 carbon atoms, and p and q are each a repeating unit A 2 O and A 3 The average number of repetitions in O is a number that is independent of any other number and is non-negative, with p+q = 1 to 50.

[0025] In formula (2), R 3To obtain excellent cleaning properties, linear alkyl or alkenyl groups having 6 to 18 carbon atoms, or branched alkyl or alkenyl groups having 6 to 18 carbon atoms are preferred, linear alkyl or alkenyl groups having 8 to 18 carbon atoms, or branched alkyl or alkenyl groups having 8 to 18 carbon atoms are more preferred, and linear alkyl or alkenyl groups having 10 to 18 carbon atoms, or branched alkyl or alkenyl groups having 10 to 18 carbon atoms are even more preferred. Also, A 2 O and A 3 For excellent cleaning properties, O is preferably an alkylene oxy group having 2 to 3 carbon atoms, independently of each other. -(A 2 O) p -and-(A 3 O) q - Different A 2 O and A 3 The order of the O's may be random or in a block-like pattern. Furthermore, the sum of p and q (p+q) is preferably 1 to 30, more preferably 4 to 20, and even more preferably 6 to 16, in order to obtain excellent cleaning performance.

[0026] (Polyoxyethylene fatty acid ester) Examples of polyoxyethylene fatty acid esters include compounds represented by the following general formula (3).

[0027] [ka] (In the formula, R 4 (where is a linear alkyl or alkenyl group having 8 to 24 carbon atoms, or a branched alkyl or alkenyl group having 8 to 24 carbon atoms; EO is an alkylene oxy group having 2 carbon atoms; and r represents the average number of repeats of the repeating unit EO, a number from 1 to 50.)

[0028] In formula (3), R 4To obtain excellent cleaning properties, a linear alkyl or alkenyl group having 8 to 18 carbon atoms, or a branched alkyl or alkenyl group having 8 to 18 carbon atoms, is more preferable. Furthermore, for obtaining excellent cleaning properties, r is preferably 1 to 50, more preferably 1 to 30, and even more preferably 1 to 20.

[0029] (Alkyl polyglycoside) Examples of alkyl polyglycosides include compounds represented by the following general formula (4).

[0030] [ka] (In the formula, a represents the number of carbon atoms in the alkyl group, which is between 4 and 18, and b is glucose (C6H 10 This represents the average number of bonds in O5, and is a number between 1 and 3.

[0031] Examples of compounds represented by general formula (4) include butyl glycosides, hexyl glycosides, octyl glycosides, decyl glycosides, lauryl glycosides, and coconut oil alkyl glycosides. Furthermore, in order to obtain excellent cleaning performance, a is preferably 4 to 16, and more preferably 6 to 16. Furthermore, in order to obtain excellent cleaning performance, b is preferably 1.1 to 2.7, and more preferably 1.2 to 2.

[0032] (Aliphatic alkanolamide) Aliphatic alkanolamides are dehydration condensates of fatty acids and organic amines, and examples include mono- or dialkanolamide compounds of fatty acids having 8 to 24 carbon atoms and amines having 2 to 3 carbon atoms. Specific examples of compounds include coconut oil fatty acid diethanolamide, coconut oil fatty acid N-methylethanolamide, lauric acid monoisopropanolamide, and palmitic acid monoethanolamide. For superior cleaning performance, coconut oil fatty acid diethanolamide and coconut oil fatty acid-N-methylethanolamide are preferred.

[0033] (Polyhydric alcohol esters) Examples of polyhydric alcohol esters include mono, di, or triester compounds of sorbitan fatty acids having 8 to 24 carbon atoms and ethylene oxide, polyglycerol fatty acid ester compounds of fatty acids having 8 to 24 carbon atoms and glycerol, and sucrose fatty acid ester compounds of fatty acids having 8 to 24 carbon atoms and sucrose. For excellent cleaning performance, polyoxyethylene sorbitan monolaurate is preferred.

[0034] <(B) Ionic surfactants> (B) The ionic surfactant includes at least one selected from the group consisting of (B-1) anionic surfactants, (B-2) cationic surfactants, and (B-3) amphoteric surfactants. To obtain excellent cleaning properties, it is preferable to include at least a (B-1) anionic surfactant.

[0035] [(B-1) Anionic surfactant] (B-1) Examples of anionic surfactants include alkyl sulfonates, alkyl sulfate salts, and carboxylates.

[0036] (Alkyl sulfonate) Examples of alkyl sulfonates include compounds represented by the following general formula (5).

[0037] [ka] (In the formula, R 5 R is a linear alkyl or alkenyl group which may contain an aromatic compound having 6 to 30 carbon atoms, or a branched alkyl or alkenyl group which may contain an aromatic compound having 6 to 30 carbon atoms. 4 This may include ether bonds, ester bonds, and amide bonds. 1 (This refers to a hydrogen atom or a cation.)

[0038] Examples of cations that form a counter salt in general formula (5) include alkali metal ions, alkanolammonium ions, and ammonium ions. Examples of alkali metal ions include sodium ions, potassium ions, and lithium ions, while examples of alkanol ammonium ions include monoethanolammonium ions, diethanolammonium ions, and triethanolammonium ions. R 5 To obtain excellent cleaning properties, a linear alkyl or alkenyl group which may contain an aromatic compound having 6 to 20 carbon atoms, or a branched alkyl or alkenyl group which may contain an aromatic compound having 6 to 20 carbon atoms, is preferred.

[0039] (Alkyl sulfate salt) Examples of alkyl sulfate ester salts include compounds represented by the following general formula (6).

[0040] [ka] (In the formula, R 6 A is a linear alkyl or alkenyl group which may contain an aromatic compound having 6 to 30 carbon atoms, or a branched alkyl or alkenyl group which may contain an aromatic compound having 6 to 30 carbon atoms, and may contain ether bonds, ester bonds, and amide bonds. 4 O is an alkylene oxy group with 2 to 4 carbon atoms, and u is a repeating unit A. 4 X represents the average number of repetitions of O, and is a number between 0 and 20. 2 (This refers to a hydrogen atom or a cation.)

[0041] Examples of cations that form a counter salt in general formula (6) include alkali metal ions, alkanolammonium ions, and ammonium ions. Examples of alkali metal ions include sodium ions, potassium ions, and lithium ions, while examples of alkanol ammonium ions include monoethanolammonium ions, diethanolammonium ions, and triethanolammonium ions. ru. R 6 To obtain excellent cleaning properties, a linear alkyl or alkenyl group which may contain an aromatic compound having 6 to 20 carbon atoms, or a branched alkyl or alkenyl group which may contain an aromatic compound having 6 to 20 carbon atoms, is preferred. Furthermore, in order to obtain excellent cleaning performance, A 4 O is preferably an alkylene oxy group having 2 to 3 carbon atoms. -(A 4 O) u - Different A 4 The order of the O's may be random or in a block-like pattern. Furthermore, in order to obtain excellent cleaning performance, u is preferably 0 to 10, more preferably 0 to 4, and even more preferably 0.

[0042] (Carboxylate salt) Examples of carboxylate salts include compounds represented by the following general formula (7) or general formula (8).

[0043] [ka]

[0044] [ka] (In the formula, R 7 X is a linear alkyl or alkenyl group which may contain an aromatic compound having 6 to 30 carbon atoms, or a branched alkyl or alkenyl group which may contain an aromatic compound having 6 to 30 carbon atoms, and may contain ether bonds, ester bonds, and amide bonds. 3 (These are hydrogen ions or cations.)

[0045] In equations (7) and (8), examples of cations that form a counter salt include alkali metal ions, alkanolammonium ions, and ammonium ions. Examples of alkali metal ions include sodium ions, potassium ions, and lithium ions, and examples of alkanolammonium ions include monoethanolammonium ions, diethanolammonium ions, and triethanolammonium ions. To achieve excellent cleaning performance, R 7 Preferably, the group is a linear alkyl or alkenyl group which may contain an aromatic compound having 6 to 28 carbon atoms, or a branched alkyl or alkenyl group which may contain an aromatic compound having 6 to 28 carbon atoms, and more preferably, a linear alkyl or alkenyl group which may contain an aromatic compound having 8 to 20 carbon atoms, or a branched alkyl or alkenyl group which may contain an aromatic compound having 8 to 20 carbon atoms.

[0046] [(B-2) Cationic surfactants] (B-2) Examples of cationic surfactants include quaternary ammonium compounds. (Quaternary ammonium compounds) Examples of quaternary ammonium compounds include alkyl (12-16 carbon atoms) dimethylammonium chloride, dimethylalkyl (12-16 carbon atoms) hydroxyethylammonium butyl phosphate, and didodecyldimethylammonium chloride. For excellent cleaning performance, alkyl (12-16 carbon atoms) dimethylammonium chloride and dimethylalkyl (12-16 carbon atoms) hydroxyethylammonium butyl phosphate esters are preferred.

[0047] [(B-3) Amphoteric surfactants] (B-3) Examples of amphoteric surfactants include amine oxides, alkyl betaines, and lecithin.

[0048] (Amine oxide) Examples of amine oxides include lauryldimethylamine oxide and lauramidopropylamine oxide. (Alkylbetaine) Examples of alkyl betaines include lauryldimethylaminoacetic acid betaine, myristyl betaine, and stearyl betaine. (lecithin) Examples of lecithin include lecithin, fractional lecithin, and enzymatically hydrolyzed lecithin.

[0049] <(C)Enzyme> (C) Examples of enzymes include proteases, amylases, lipases, cellulases, and mannanases. These may be used individually or in combination of two or more. To obtain excellent cleaning performance, it is preferable that (C) enzyme contains at least a protease. For the protease, commercially available enzyme preparations containing proteases can be used, such as Progress Uno 100L (manufactured by Novozymes) or Bioplase NK-60 (manufactured by Nagase Vita Co., Ltd.).

[0050] <(D) Solvent> The solvent (D) contained in the liquid cleaning agent composition for hard surfaces is an aqueous solvent and may contain water, or water and an aqueous organic solvent.

[0051] [water] The water contained in the liquid cleaning agent composition for hard surfaces is preferably one with a low metal salt content. Examples include, but are not limited to, deionized water, distilled water, pure water, ultrapure water, purified water, and water for injection. The water content in the liquid cleaning agent composition for hard surfaces is preferably 0.01 to 20% by mass, more preferably 0.01 to 15% by mass, even more preferably 1 to 15% by mass, and particularly preferably 7 to 10% by mass. By keeping the water content within the above range, when filling the hard surface liquid cleaning agent composition into a container, it is easier to ensure the necessary fluidity of the hard surface liquid cleaning agent composition, and it is possible to avoid situations where the water-soluble film constituting the container breaks and the contents of the hard surface liquid cleaning agent composition leak out during filling into the container and during storage of the individual hard surface liquid cleaning agent packaging after filling.

[0052] [Organic solvents] The organic solvent contained in the liquid cleaning agent composition for hard surfaces is appropriately selected depending on the type and amount of (A) nonionic surfactant, (B) ionic surfactant, and (C) enzyme, but an aqueous organic solvent with high solubility in water is preferred, and specifically glycol-based solvents such as ethylene glycol, propylene glycol, and dipropylene glycol are preferred. The liquid cleaning agent composition for hard surfaces does not necessarily have to contain organic solvents, but if it does, the content of organic solvents is preferably 80% by mass or less, and is between 0.01 and 50%. It is more preferably a mass percent, and even more preferably 10 to 30 mass percent.

[0053] Furthermore, in order to obtain excellent applicability to cleaning baths, it is preferable to increase the content of water or organic solvent in the hard surface liquid cleaning agent composition, thereby increasing the content of solvent (D) in the hard surface liquid cleaning agent composition. In this case, the following are preferred for the respective contents of water and organic solvent in the hard surface liquid cleaning agent composition. The water content in the liquid cleaning agent composition for hard surfaces is preferably 0.01 to 20% by mass when the solvent content (D) is 5 to 88% by mass, more preferably 1 to 15% by mass when the solvent content (D) is 20 to 80% by mass, and even more preferably 7 to 10% by mass when the solvent content (D) is 35 to 80% by mass.

[0054] The content of organic solvent in the liquid cleaning agent composition for hard surfaces is preferably 20 to 80% by mass, and more preferably 30 to 70% by mass. Furthermore, the mass ratio of organic solvent to water in solvent (D) is preferably 0.65 / 1 to 0.95 / 1, and more preferably 0.75 / 1 to 0.9 / 1.

[0055] <(E) Additives> Examples of additives (E) that can be contained in the hard surface liquid cleaning agent composition of the present invention include hydrotropes, chelating agents, dispersants, defoamers, structural viscosity modifiers, texture enhancers such as silicones, preservatives, fragrances, and general-purpose dyes or pigments as colorants.

[0056] Examples of hydrotropes include p-toluenesulfonic acid or its salts, cumenesulfonic acid or its salts, benzoates, and urea. These hydrotropes may be used individually or in combination of two or more. The hydrotrope content in the hard surface liquid cleaning agent composition is preferably 0.01 to 15% by mass.

[0057] Examples of chelating agents include organic chelating agents, specifically citric acid, lactic acid, tartaric acid, oxalic acid, malic acid, gluconic acid, nitrilotriacetic acid, iminodiacetic acid, ethylenediaminetetraacetic acid, diethylenetriaminepentaacetic acid, glycol etherdiaminetetraacetic acid, hydroxyethyliminodiacetic acid, triethylenetetraaminehexaacetic acid, ethane-1,1-diphosphonic acid, ethane-1,1,2-triphosphonic acid, trisodium methylglycinediacetate, 1-hydroxyethane-1,1-diphosphonic acid, ethanehydroxy-1,1,2-triphosphonic acid, ethane-1,2-dicarboxy-1,2-diphosphonic acid, methanehydroxyphosphonic acid, aminotrimethylenephosphonic acid, ethylenediaminetetraximethylenesulfonic acid, and other organic phosphonic acid derivatives or salts thereof. These may be used alone or in combination of two or more.

[0058] <Water-soluble film> The water-soluble film used in containers that enclose liquid cleaning agents for hard surfaces to form individual packages of these cleaning agents is preferably one that exhibits high solubility in water but low solubility in the liquid cleaning agent itself.

[0059] Examples of resins that make up water-soluble films include polyvinyl alcohol, polyvinylpyrrolidone, polyalkylene oxide, acrylamide, acrylic acid, cellulose, cellulose ether, cellulose ester, celluloseamide, polyvinyl acetate, polycarboxylic acid or its salts, polyamino acids or peptides, polyamide, polyacrylamide, copolymers of maleic acid and acrylic acid, polysaccharides containing starch and gelatin, and natural rubbers such as xanthan gum or kara rubber. Among these, polyvinyl alcohol is preferred.

[0060] If the packaging material forming the container is water-soluble, when using individual packets of liquid cleaning agent for hard surfaces, it is easy to dissolve them in the cleaning bath in a suitable amount of time, releasing and dissolving the liquid cleaning agent for hard surfaces into the cleaning bath.

[0061] <Objects to be cleaned: Hard surfaces> The objects to be cleaned by the individually packaged liquid cleaning agent for hard surfaces of the present invention are the hard surfaces of parts (hard parts) made of hard materials such as metal, resin, rubber, glass, and ceramics, and examples include the hard surfaces of medical devices. When the object to be cleaned is the surface of a medical device, metal or resin is preferred as the hard material. The type of metal is not particularly limited, but examples include iron, copper, and stainless steel. The type of resin is not particularly limited, but examples include polytetrafluoroethylene, polyacetal, polyvinyl chloride, and polycarbonate.

[0062] <Method for manufacturing individually packaged liquid cleaning agents for hard surfaces> The individual packaging of the liquid cleaning agent for hard surfaces of the present invention is manufactured, for example, using a mold in which multiple square recesses are formed, as follows. First, a single water-soluble film is placed so as to cover the openings of the multiple recesses. Then, the pressure inside the recess is reduced, and a water-soluble film is drawn into and attached to the recess, forming a storage compartment with an open top. The volume of one storage compartment is approximately 5 to 30 mL. Next, a liquid cleaning agent for hard surfaces is filled into the container. Next, another moistened water-soluble film is placed to cover the opening of the container filled with the hard surface liquid cleaning agent, sealing the agent, and then the container is removed from the mold. Subsequently, by individually cutting out each storage section, individual packages of liquid cleaning agent for hard surfaces can be obtained, in which the liquid cleaning agent for hard surfaces is filled into a container made of water-soluble film.

[0063] <Instructions for using individually packaged liquid cleaning agents for hard surfaces> The individually packaged liquid cleaning agent for hard surfaces of the present invention eliminates the need to measure the cleaning agent as in conventional methods; only the appropriate number of individually packaged liquid cleaning agents for hard surfaces should be used according to the object to be cleaned and the amount of cleaning bath. Therefore, it offers high simplicity and convenience. When using individual packets of liquid cleaning agent for hard surfaces, the individual packets may be placed in a cleaning bath to dissolve the water-soluble film packaging bag in the cleaning bath, thereby releasing and dissolving the contents of the liquid cleaning agent into the cleaning bath. Alternatively, the individual packets of liquid cleaning agent for hard surfaces may be torn open to release and dissolve the contents of the liquid cleaning agent into the cleaning bath. There are no particular restrictions on the amount of cleaning bath or the quantity of hard surface liquid cleaning agent used, but for example, one individual package of hard surface liquid cleaning agent may be used for a cleaning bath of 10,000 to 20,000 mL.

[0064] (Method for cleaning hard surfaces of objects to be cleaned) The cleaning method for an object or hard surface using the individually packaged liquid cleaning agent for hard surfaces of the present invention is not particularly limited as long as it involves bringing a cleaning bath containing the liquid cleaning agent for hard surfaces in contact with the hard surface of the object to be cleaned that has dirt attached to it. Examples include immersing the object to be cleaned in the cleaning bath or spraying the cleaning bath (cleaning solution) onto the hard surface of the object to be cleaned. The individually packaged liquid cleaning agent for hard surfaces of the present invention is particularly suitable for methods in which the object to be cleaned is immersed in a cleaning bath.

[0065] (Washing temperature) The cleaning temperature, that is, the temperature of the cleaning bath (cleaning solution) in which the liquid cleaning agent for hard surfaces is dissolved, is not particularly limited. The ideal temperature is not fixed and is determined as appropriate during cleaning, but to obtain excellent cleaning performance, 10 to 80°C is preferred, and 20 to 60°C is more preferred. [Examples]

[0066] The present invention will be described in detail below with reference to examples, but the present invention is not limited to the following description.

[0067] <Raw materials used> [Water-soluble film] • Water-soluble film made of polyvinyl alcohol (product name "M8312", manufactured by Monosol LLC).

[0068] [Nonionic surfactants] A1: Polyoxyethylene (8) decyl ether (an EO8 molar adduct of branched decyl alcohol, trade name "Lutensol XP 80", manufactured by BASF, containing 100% by mass of solids (components other than solvent).) A2: Polyoxyethylene (10) decyl ether (an EO10 molar adduct of branched decyl alcohol. Trade name "Lutensol XP 100", manufactured by BASF, containing 100% by mass of solids (components other than solvent).) A3: Polyoxyethylene (10) decyl ether (an EO10 molar adduct of a straight-chain decyl alcohol. Product name: "FineSurf D-1310", manufactured by Aoki Oil & Fat Industry Co., Ltd., containing 100% by mass of solids (components other than solvents).) A4: Polyoxyethylene (9) alkyl ether (an EO9 molar adduct of a linear alcohol with 12-14 carbon atoms. Trade name "Softanol 90", manufactured by Nippon Shokubai Co., Ltd., containing 100% by mass of solids (components other than solvents).) A5: Polyoxyethylene (12) polyoxypropylene (3) alkyl ether (an adduct of linear C12-C14 alcohols, consisting of 12 molars of EO and 3 molars of PO. Trade name "L1203P", manufactured by Nikka Chemical Co., Ltd., containing 100% by mass of solids (components other than solvents).)

[0069] A6: Polyoxyethylene (10) oleyl ether (an EO10 molar adduct of linear oleyl alcohol. Trade name "NIKKOL BO-10V", manufactured by Nikko Chemicals Co., Ltd., containing 100% by mass of solids (components other than solvents).) A7: Polyoxyethylene (10) alkyl monobutyl ether (a dehydration condensate of an EO10 molar adduct of a linear C12-C14 alcohol and butyl alcohol. Trade name "Dehypon LT 104", manufactured by BASF, containing 100% by mass of solids (components other than solvent).) A8: Polyoxyethylene (10) coconut alkylamine (EO10 molar adduct of coconut alkylamine. Trade name "BT-231N", manufactured by Nikka Chemical Co., Ltd., contains 100% by mass of solids (components other than solvent).) A9: Contains 100% by mass of polyoxyethylene (15) alkylamine (an EO15 molar adduct of alkylamines with 16 to 18 carbon atoms; trade name "SA-15", manufactured by Nikka Chemical Co., Ltd.), which is the solid content (components other than solvent). A10: n-Hexylglycoside (a C6 alkyl glycoside. Trade name "Hexylglycoside," manufactured by Tokyo Chemical Industry Co., Ltd., containing 100% by mass of solids (components other than solvents).)

[0070] A11: Coconut oil fatty acid N-methylethanolamide (a dehydrated condensate of coconut oil fatty acid and methylethanolamine. Product name: "Aminone C-11S", manufactured by Kao Corporation, contains 100% by mass of solids (components other than solvents).) A12: Polyoxyethylene (20) sorbitan monolaurate (lauric acid EO2) Dehydrated condensate of 0 molar adduct and sorbitan. Product name "TW-L120", manufactured by Kao Corporation, 100% by mass. A13: Polyethylene glycol (12) monolaurate (EO12 molar adduct of lauric acid. Trade name "Emanon 1112", manufactured by Kao Corporation, contains 100% by mass of solids (components other than solvents).)

[0071] [Anionic surfactants] • B1: Sodium alkylbenzenesulfonate (sodium salt of alkylbenzenesulfonic acid with 10 to 16 carbon atoms. Contains 100% by mass of solid content (components other than solvent) from a 1:1 (molar ratio) reaction product of Teika Power L121 (manufactured by UBE Co., Ltd.) and flake caustic soda (manufactured by Central Glass Co., Ltd.).) • B2: Sodium α-olefin sulfonate (Sodium salt of sulfonated α-olefins with 14-16 carbon atoms. Product name "Neogen AO-90", manufactured by Daiichi Kogyo Co., Ltd., contains 100% by mass of solids (components other than solvents).) • B3: Sodium alkanesulfonate (sodium salt of alkanesulfonic acid with 13-17 carbon atoms. Product name "Hostapur SAS60", manufactured by Clariant Japan Co., Ltd., an aqueous solution containing 60% by mass of solids (components other than solvent).) • B4: Sodium dialkyl sulfosuccinate (sodium salt of an ester of sulfosuccinate between an alcohol with 11-14 carbon atoms. Product name: "Adekacol EC-8600", manufactured by Adeka Co., Ltd., an aqueous solution containing 70% by mass of solids (components other than solvent).) • B5: Sodium laurate (a 1:1 (molar ratio) reaction product of Laurinsan P (manufactured by Shin-Nippon Rika Co., Ltd.) and flake caustic soda (manufactured by Central Glass Co., Ltd.), containing 100% by mass of solid content (components other than solvent).)

[0072] • B6: Contains 100% by mass of solids (components other than solvent), a 1:1 (molar ratio) reaction product of sodium oleate (NAA-34 (manufactured by NOF Corporation)) and flake caustic soda (manufactured by Central Glass Co., Ltd.). • B7: Contains 100% by mass of solids (components other than solvent), a 1:1 (molar ratio) reaction product of sodium octanoate (NAA-82 (manufactured by NOF Corporation)) and flake caustic soda (manufactured by Central Glass Co., Ltd.). • B8: Sodium dodecanediate (a 1:2 (molar ratio) reaction product of dodecanediate (manufactured by UBE Co., Ltd.) and flake caustic soda (manufactured by Central Glass Co., Ltd.), containing 100% by mass of solids (components other than solvent).) • B9: Sodium ethylhexyl sulfate (product name "Zintrekiss EH-R", manufactured by NOF Corporation, an aqueous solution containing 40% by mass of solids (components other than solvents).) • B10: Sodium dodecyl sulfate (product name "Emal 10G", manufactured by Kao Corporation, a hydrate (powder) containing 98% by mass of solids (components other than solvents).) • B11: Sodium polyoxyethylene (3) alkyl ether sulfate (sodium sulfate salt of a linear C10-C16 alcohol oxyethylene 3-mol adduct. Product name "Emal 327", manufactured by Kao Corporation, an aqueous solution containing 35% by mass of solids (components other than solvents).)

[0073] [Amphoteric surfactants] • B12: Lauryldimethylamine oxide (product name "Anhithol 20N", manufactured by Kao Corporation, an aqueous solution containing 35% by mass of solids (components other than solvents).) • B13: Lauryl betaine (product name "Licabion A-100", manufactured by Shin Nippon Rika Co., Ltd., an aqueous solution containing 65% by mass of solids (components other than solvents).) • B14: Lecithin (product name "SLP-Paste", manufactured by Tsuji Oil Co., Ltd., contains 100% by mass of solids (components other than solvents).)

[0074] [Cationic surfactants] B15: Coconut alkyldimethylbenzylammonium chloride (product name "Nikkanon") "50", manufactured by Nikka Chemical Co., Ltd., an aqueous solution containing 50% by mass of solids (components other than solvents).

[0075] [enzyme] • C1: Protease (product name "Progress UNO 100L", manufactured by Novozymes, an aqueous solution containing 10% by mass of solids (components other than solvent).) • C2: Lipase (product name "Entilon LP CONC", manufactured by Rakuto Kasei Kogyo Co., Ltd., an aqueous solution containing 46% by mass of solids (components other than solvents).) • C3: Amylase (product name "PAS-600 Eco", manufactured by Rakuto Kasei Kogyo Co., Ltd., an aqueous solution containing 12% by mass of solids (components other than solvents).) • C4: Cellulase (product name "Celluclean 5000L", manufactured by Novozymes, an aqueous solution containing 5% by mass of solids (components other than solvent).)

[0076] [solvent] • D1: Propylene glycol (product name "Propylene Glycol", manufactured by Dow, 100% by mass). • D2: Ethylene glycol (product name "Ethylene Glycol", manufactured by Mitsubishi Chemical Corporation, 100% by mass). • D3: Glycerin (product name "Glycerin", manufactured by Miyoshi Oil & Fat Co., Ltd., 100% by mass). • D4: Dipropylene glycol (product name "Dipropylene Glycol", manufactured by Adeka Co., Ltd., 100% by mass). • D5: Triethanolamine (product name "Triethanolamine", manufactured by Mitsui Chemicals, Inc., 100% by mass). • Water: Ion-exchanged water

[0077] [Additives] • E1: Sodium methylbenzenesulfonate (product name "TAYCATOX N6030", manufactured by Teika Co., Ltd., an aqueous solution containing 30% by mass of solids (components other than solvent).) • E2: Sodium xylene sulfonate (product name "SXA-60", manufactured by Hokusei Kogyo Co., Ltd., an aqueous solution containing 40% by mass of solids (components other than solvent).) • E3: Sodium methylglycine diacetate (product name "Trilon M Granules", manufactured by BASF, an aqueous solution containing 40% by mass of solids (components other than solvents).) • E4: Sodium polyacrylate (product name "Aron T-50", manufactured by Toagosei Co., Ltd., an aqueous solution containing 50% by mass of solids (components other than solvents).) • E5: Sodium salt of polyacrylic acid / polymaleic acid copolymer (product name "Sokalan CP-5", manufactured by BASF, aqueous solution containing 40% by mass of solids (components other than solvent)). • E6: Calcium additive (product name "Calcium Chloride", manufactured by Nippon Soda Co., Ltd., containing 100% by mass of solids (components other than solvent)).

[0078] [Example 1] (Preparation of liquid cleaning agent compositions for hard surfaces) In a 500 mL beaker, the raw materials other than (D) the solvent were added so that the solid content (components other than the solvent) of each raw material was in the following parts by mass. A stirring bar was then inserted and the mixture was thoroughly stirred using a magnetic stirrer (manufactured by AS ONE Corporation). (A) Nonionic surfactant: A1 65 parts by mass (B) Ionic surfactant: B1 25 parts by mass (C) Enzyme: C1 0.5 parts by mass (D) Solvent: Water 9.5 parts by mass In the above, for example, since the solid content (components other than solvent) of enzyme C1 is 10% by mass, in order to add 0.5 parts by mass of C1 solids, product C1 would need to be added in 0.5 parts by mass / 0.1 = 5 parts by mass. Next, since 4.5 parts by mass of water derived from C1 were present in the beaker, 5 parts by mass of water were added so that the total amount of water derived from C1 and the added water was 9.5 parts by mass of (D) solvent:water. The mixture was then thoroughly stirred to obtain a liquid cleaning agent composition for hard surfaces. In this invention, the solid content (components other than the solvent) refers to the residual amount (mass%) after heating and drying in a 105°C dryer for 3 hours.

[0079] (Manufacturing of individually packaged liquid cleaning agents for hard surfaces) Two 55mm x 90mm film pieces were cut from a roll of water-soluble film. These were then stacked and three sides were heat-sealed to create a packaging bag with one side left unsealed. Next, 10 g of the liquid cleaning agent for hard surfaces, consisting of the hard surface liquid cleaning agent composition obtained above, was filled into the packaging bag prepared above, starting from one side that was not heat-sealed. Then, the side that had not been heat-sealed was heat-sealed to obtain individual packaging for liquid cleaning agent for hard surfaces. Then, various evaluations were conducted on the individually packaged liquid cleaning agents for hard surfaces obtained as described above.

[0080] [Examples 2-73, Comparative Examples 1-5] Liquid cleaning agent compositions for hard surfaces were prepared by the same procedure as in Example 1, so that the solid content (components other than solvent) of each raw material was in parts by mass as shown in [Table 1] to [Table 7]. Individual packages of the liquid cleaning agent for hard surfaces were then prepared and evaluated in the same manner. If the solid content (components other than solvent) of each raw material was less than 100% by mass, the total amount of water, including the amount derived from each raw material and the amount of water added, was set to the amount shown in (D) Water, as in Example 1. Tables 1 to 7 show the amount (parts by mass) of each raw material as solid content (components other than solvent).

[0081] <Rating> [Sheep blood washability] The work was carried out in accordance with the 2020 Guidelines for Sterilization Assurance in Medical Settings. A mixture for simulating protein staining was prepared by mixing heparinized sheep blood, purified water, and a 1% protamine sulfate aqueous solution in a volume ratio of 10:1:0.15. The resulting mixture for simulated protein staining was dropped onto a SUS304 piece (JIS G4305, size: 2.5cm x 5cm x 1mm) at a rate of 100 μL (15mm x 30mm) using a micropipette, and dried at 45°C for 1 hour to allow the simulated protein stain to adhere. Next, 10,000 mL of water was added to the washing bath, and then one individual package of the hard surface liquid cleaning agent of the present invention was added. The contents were thoroughly dissolved and stirred to prepare the washing bath. Three pieces of SUS304 with simulated protein stains attached were placed in the resulting washing bath, left to stand at 40°C for 5 minutes, then immediately removed by immersion in a container filled with deionized water, rinsed, and dried at 80°C for 30 minutes.

[0082] After drying, the SUS304 pieces with simulated protein stains attached were placed in an extraction bag. 10 mL of 1% sodium dodecyl sulfate aqueous solution (pH 11 ± 0.5) was measured out using a micropipette and poured into the extraction bag containing the SUS304 pieces. Sonication was then performed at 55°C for 30 minutes.

[0083] After sonication, 1 mL of the 1% sodium dodecyl sulfate aqueous solution from the extraction bag was taken using a micropipette and placed in a 5 mL test tube. Then, 2 mL of the BCA indicator solution (Pierce™ BCA Protein Assay Kits, Thermo Scientific) was measured using a micropipette and added to the 5 mL test tube. The 5 mL test tube was then heated in a 60°C bath for 30 minutes, and then allowed to cool naturally at 25°C. After natural cooling, the absorbance of the solution in the test tube at a wavelength of 562 nm was measured using a Hitachi High-Technologies Corporation U-3410 Spectrophotometer. A blank sample was prepared using the same procedure as above, except that the dried SUS304 pieces were not included. The absorbance was then measured in the same manner.

[0084] First, albumin standard solutions were progressively diluted with 1% sodium dodecyl sulfate aqueous solution (pH 11 ± 0.5), and the absorbance of these dilutions at a wavelength of 562 nm was measured to create a calibration curve. The amount of residual protein was calculated by applying the absorbance values ​​obtained above to the resulting calibration curve. Washing, absorbance measurement, and calculation of residual protein content were performed three times for each sample, and the average value was scored according to the evaluation criteria below. A score of 2 or higher was considered a passing grade. Evaluation Criteria 3 points: Residual protein content is less than 50 μg Two points: Residual protein content is 50 μg or more, but less than 100 μg. 1 point: Residual protein content is 100 μg or more

[0085] [Enzyme stability] A reaction solution was prepared by mixing milk casein (casein from milk, manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.), sodium dihydrogen phosphate, and deionized water to the following concentrations. Reaction solution: • Milk casein 0.6% by mass • Sodium dihydrogen phosphate 0.55% by mass

[0086] Sodium chloride, calcium acetate, and sodium acetate were mixed with deionized water to the following concentrations to prepare a diluted solution. Diluent: • Sodium chloride 3g / L Calcium acetate 0.175 g / L Sodium acetate 1.667 g / L

[0087] A trichloroacetic acid solution was prepared by mixing trichloroacetic acid, anhydrous sodium acetate, and acetic acid with deionized water to the following concentrations. Trichloroacetic acid solution: Trichloroacetic acid: 17.97 g / L • Anhydrous sodium acetate: 18.04 g / L Acetic acid: 19.81 g / L

[0088] For the individually packaged liquid cleaning agent for hard surfaces of the present invention, samples manufactured within 24 hours were used as pre-test samples, and samples left at 30°C for one month after manufacturing were used as post-test samples. Break open the individual packaging of each sample, remove the hard surface liquid cleaning agent from the contents, and dilute it with the above diluent to a concentration of 0.001% by mass. A sample solution was obtained. Then, 1 mL of the diluted sample solution obtained above was mixed with 5 mL of the reaction solution prepared above, and the mixture was allowed to stand at 30°C for 10 minutes to react. After that, 5 mL of the trichloroacetic acid solution prepared above was added, and the mixture was allowed to stand at 30°C for 30 minutes. The resulting diluted sample solution was filtered through a membrane filter (pore size 0.45 μm, product number "4-880-02", manufactured by ADVANTEC Corporation), and the filtrate was collected. Then, 5 mL of 0.55 M sodium carbonate aqueous solution and 1 mL of Folin reagent (a solution prepared by mixing Folin reagent and deionized water in a volume ratio of 1:2) were added to 2 mL of the filtrate, and after standing at 30°C for 30 minutes, the absorbance at a wavelength of 660 nm was measured (instrument name: U-3410 Spectrophotometer, manufactured by Hitachi High-Technologies Corporation).

[0089] For the absorbance measurement, the blank solution used was one that was tested in the same manner as described above, except that 5 mL of trichloroacetic acid solution was added to the solution before the reaction solution was added, which was a solution of liquid detergent composition diluted with a diluent, rather than the solution after the reaction.

[0090] L-tyrosine (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.) was progressively diluted with 0.2 M hydrochloric acid, and a calibration curve was created by measuring the absorbance of 2 mL of each hydrochloric acid dilution of L-tyrosine at a wavelength of 660 nm. 0.2 M hydrochloric acid was used as the blank for the absorbance measurements. The absorbance values ​​of the samples measured above were applied to the calibration curve created above to determine the residual enzyme concentration in the samples.

[0091] The enzyme activity value obtained by reacting 1 μg of L-tyrosine at 30°C for 1 minute was converted to 1 protease unit (1 PU), and the enzyme activity value was calculated from the residual enzyme concentration of the sample before and after the start of the test. The protease retention rate (%) was then calculated using the following formula. Protease retention rate (%): (Enzyme activity value of sample after start of test / Enzyme activity value of sample before start of test) × 100 The calculated protease retention rate was scored according to the following evaluation criteria, with a score of 2 or higher considered a passing grade. Evaluation Criteria 3 points: Protease retention rate (%) is 95% or higher. 2 points: Protease retention rate (%) is between 90% and 95%. 1 point: Protease retention rate (%) is less than 90%

[0092] [Suitability for use in washing baths] 200 mL of deionized water at 25°C was poured into a 200 mL beaker. Next, 9 g of the liquid cleaning agent for hard surfaces, consisting of the hard surface cleaning agent compositions obtained in each example, was added to the above-mentioned deionized water. The dispersibility of the liquid cleaning agent for hard surfaces into deionized water after addition was visually evaluated and scored according to the following evaluation criteria. Evaluation Criteria 3: There were no gels or lumps, and it dissolved quickly and uniformly without stirring. 2: Although there were gels and lumps, they dissolved slowly over time without stirring. 1: There were gels and lumps present, but they dissolved upon stirring.

[0093] [Table 1]

[0094] [Table 2]

[0095] [Table 3]

[0096] [Table 4]

[0097] [Table 5]

[0098] [Table 6]

[0099] [Table 7]

[0100] <Summary of Evaluation Results> The individually packaged liquid cleaning agents for hard surfaces described in Examples 1 to 53 of the present invention exhibited excellent sheep blood washing properties and enzyme stability. Furthermore, the individually packaged liquid cleaning agents for hard surfaces in Examples 54-73 demonstrated excellent sheep blood cleaning ability, enzyme stability, and cleaning bath spreadability. However, Comparative Examples 1, 2, and 5, in which the liquid cleaning agent composition for hard surfaces did not contain any of (A) a nonionic surfactant, (B) an ionic surfactant, or (C) an enzyme, and Comparative Examples 3 and 4, in which the mass ratio (A) / (B) was outside the range of 2 / 1 to 200 / 1, showed inferior sheep blood cleaning ability and / or enzyme stability. [Industrial applicability]

[0101] The individually packaged liquid detergent for hard surfaces of the present invention is individually packaged, possesses high cleaning power against hard surfaces, and exhibits excellent long-term stability of the enzymes contained in the liquid detergent for hard surfaces. Furthermore, by adjusting the content of each component, such as increasing the content of (D) solvent and decreasing the content of (A) nonionic surfactant and (B) ionic surfactant in the liquid detergent composition for hard surfaces, the individually packaged liquid detergent for hard surfaces of the present invention also exhibits excellent dispersibility into a cleaning bath. Therefore, it can be used as a simple and convenient individually packaged detergent for cleaning hard surfaces of medical devices and other items made of hard materials such as metal, resin, rubber, glass, and ceramics.

Claims

1. A liquid cleaning agent for hard surfaces is enclosed in a container made of water-soluble film, and is provided as an individual package of liquid cleaning agent for hard surfaces. When the individual packaging of the hard surface liquid cleaning agent is thrown into the cleaning bath, the water-soluble film container dissolves in water, releasing the contents of the hard surface liquid cleaning agent into the cleaning bath. The amount of the liquid cleaning agent for hard surfaces enclosed is 5 to 50 g. The liquid cleaning agent for hard surfaces consists of a liquid cleaning agent composition for hard surfaces. The liquid cleaning agent composition for hard surfaces contains (A) a nonionic surfactant, (B) an ionic surfactant, (C) an enzyme, and (D) a solvent. (B) The ionic surfactant comprises at least one selected from the group consisting of anionic surfactants, cationic surfactants, and amphoteric surfactants. (D) The solvent contains water, or contains water and an aqueous organic solvent. The composition of the liquid cleaning agent for hard surfaces contains (A) 10 to 90% by mass of nonionic surfactant, (B) 0.1 to 30% by mass of ionic surfactant, (C) 0.01 to 20% by mass of enzyme, (D) 5 to 88% by mass of solvent, and 0.01 to 20% by mass of water. The mass ratio of (A) nonionic surfactant to (B) ionic surfactant is between 2 / 1 and 200 / 1. Individually packaged liquid cleaning agent for hard surfaces.

2. The liquid cleaning agent composition for hard surfaces contains, in proportion to (A) 10 to 50% by mass of nonionic surfactant, (B) 0.1 to 25% by mass of ionic surfactant, (C) 0.01 to 20% by mass of enzyme, (D) 5 to 88% by mass of solvent, and 0.01 to 20% by mass of water, and the mass ratio of (A) nonionic surfactant / (B) ionic surfactant is 2 / 1 to 200 / 1, as described in claim 1.

3. (A) The individual packaging of a liquid cleaning agent for hard surfaces according to claim 1, wherein the nonionic surfactant comprises at least one selected from the group consisting of compounds represented by general formula (1) and general formula (2). 【Chemistry 1】 (In the formula, R 1 R is a linear alkyl or alkenyl group having 8 to 24 carbon atoms, or a branched alkyl or alkenyl group having 8 to 24 carbon atoms. 2 A is a hydrogen atom, a linear alkyl or alkenyl group having 2 to 18 carbon atoms, or a branched alkyl or alkenyl group having 2 to 18 carbon atoms. 1 O is an alkylene oxy group having 2 to 4 carbon atoms, and n is a repeating unit A. 1 (This is the average number of repetitions of O, and is a number between 1 and 30.) 【Chemistry 2】 (wherein, R 3 is a linear alkyl group or alkenyl group having 6 to 24 carbon atoms, or a branched alkyl group or alkenyl group having 6 to 24 carbon atoms, A 2 O and A 3 O are each independently an alkyleneoxy group having 2 to 4 carbon atoms, and each of p and q is the average number of repeating units of A 2 O and A 3 O, and are each independently a number of 0 or more, p + q = 1 to 50.

4. (B) Ionic surfactants include anionic surfactants, The anionic surfactant comprises at least one selected from the group consisting of alkyl sulfonates, alkyl sulfate salts, and carboxylate salts. Individually packaged liquid cleaning agent for hard surfaces according to claim 1.

5. The hard surface is the hard surface of a medical device, as described in claim 1, in the individual packaging of a liquid cleaning agent for hard surfaces.

6. The individual packaging of a liquid cleaning agent for hard surfaces according to claim 1, wherein the water-soluble film is a water-soluble film made of polyvinyl alcohol.

7. A method for cleaning a hard surface using an individually packaged liquid cleaning agent for hard surfaces as described in any one of claims 1 to 6.

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