Deworming collar

Abstract

The objective is to provide an insecticidal collar that can suppress the bleeding of insecticidal components from the collar when it is in a sealed container such as a blister pack, and that can accommodate the unique release behavior of insecticidal components, where the insecticidal components bleed rapidly immediately after being removed from the sealed container and put into use. [Solution] A deworming collar containing a vinyl chloride resin component, an active ingredient, a volatile plasticizer, and titanium dioxide, The aforementioned active ingredient comprises one or more selected from the group consisting of phenothrin and pyriproxyfen. A deworming collar containing phenothrin, where the phenothrin content is in the range of 20-60% by weight relative to the vinyl chloride resin component.

Description

Technical Field

[0001] The present invention relates to an anti - parasite collar.

[0002] In order to exterminate pests such as fleas and ticks parasitizing on pets such as dogs and cats, anti - parasite collars molded by incorporating a pest - exterminating component into a resin component have been developed. The anti - parasite collars are stored in a sealed container such as a transparent blister packaging container immediately after production, and after transportation, they are displayed in stores. (Patent Document 1)

[0003] When the anti - parasite collar is stored in a sealed container, the pest - exterminating component does not bleed from the surface of the collar. On the other hand, as soon as the sealed container is opened and put into practical use, a sufficient amount of the pest - exterminating component bleeds from the surface of the collar without delay, and a so - called contrary and specific release behavior regarding the pest - exterminating component is required to exhibit the pest - exterminating effect.

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0005] So far, anti - parasite collars have been developed to provide the above - mentioned specific release behavior of the pest - exterminating component required for anti - parasite collars. However, depending on the storage conditions, bleeding of the pest - exterminating component may occur even inside the sealed container.

[0006] Since the blister packaging container is transparent, there is an advantage that the anti - parasite collar, which is the packaged object, can be easily visually inspected. On the other hand, if droplets due to bleeding of the pest - exterminating component are observed on the surface of the anti - parasite collar, it may lead to a decrease in the commercial value.

[0007] The present invention aims to provide an insecticidal collar that is suitable for the unique release behavior of insecticidal components, in which the bleeding of insecticidal components from the collar is further suppressed in a sealed container such as a blister packing container, and furthermore, the insecticidal components bleed rapidly immediately after being removed from the sealed container and put into use. [Means for solving the problem]

[0008] The inventors of this invention have diligently studied and investigated the problem, and as a result have arrived at the present invention. That is, the present invention is [1] A deworming collar containing a vinyl chloride resin component, phenothrin, a volatile plasticizer, and titanium dioxide. [2] The antiparasitic collar characterized in that the titanium dioxide content is 0.03% to 10.00% by weight relative to the total content of phenothrin and volatile plasticizer. [3] The antiparasitic collar, which is housed in a blister packaging container. To provide. [Effects of the Invention]

[0009] According to the present invention, the bleeding of pest control components from the collar can be further suppressed in a sealed container such as a blister packing container, and furthermore, it is possible to provide a pest control collar that is suitable for the unique release behavior of pest control components, in which the pest control components bleed rapidly immediately after being removed from the sealed container and put into use. [Modes for carrying out the invention]

[0010] The vinyl chloride resin component used in the antiparasitic collar of the present invention is preferably ZEST® 1300Z (manufactured by Shin-Daiichi Vinyl Chloride Co., Ltd.), which has good compatibility with phenothrin and excellent flexibility.

[0011] The insecticide component used in the insecticidal collar of the present invention is phenothrin. The phenothrin is blended in such a way that it is dissolved in the vinyl chloride resin component at a level greater than or equal to the saturation level, and its content is usually in the range of 20 to 60% by weight or more relative to the vinyl chloride resin.

[0012] Examples of volatile plasticizers used in the insecticidal collar of the present invention include esters, alcohols, ketones, and animal and plant essential oils that are liquid at room temperature. Examples of liquid esters include phthalates, linear dibasic acid esters, and phosphate esters, among which phosphate esters such as triethyl phosphate and tributyl phosphate are preferred.

[0013] The titanium dioxide used in the antiparasitic collar of the present invention includes rutile-type titanium dioxide and anatase-type titanium dioxide, of which rutile-type titanium dioxide is preferred. The average particle size of the titanium dioxide used is usually in the range of 0.1 to 1.0 μm. Here, the average particle size refers to the particle size (D50) at which the volume accumulation of the particle size distribution is 50%, measured by laser diffraction using a laser diffraction particle size distribution analyzer (product name "MicrotracHRA9320-X100", Nikkiso Co., Ltd.).

[0014] The titanium dioxide content is 0.03% to 10.00% by weight relative to the total content of phenothrin and volatile plasticizers. This range allows for better suppression of the bleeding of pest control components from the collar in sealed containers such as blister packaging, while allowing for rapid bleeding of the pest control components immediately after removal from the sealed container and commencement of use. Furthermore, by setting the titanium dioxide content to 0.30% to 3.00% by weight relative to the total content of phenothrin and volatile plasticizers, the bleeding of pest control components immediately after commencement of use becomes even more rapid.

[0015] The insecticidal collar of the present invention may contain an insect growth regulator as an active ingredient other than phenothrin. Examples of insect growth regulators include pyriproxyfen and bistriflurone.

[0016] The antiparasitic collar of the present invention may further contain phenothrin efficacy enhancers such as piperonyl butoxide and MGK-264.

[0017] In addition, the anti-parasitic collar of the present invention can contain a bleeding promoter, a plasticizer other than an evaporative plasticizer, a stabilizer, a dye, and the like.

[0018] Examples of the bleeding promoter include erucic acid and carboxylic acid. Examples of the carboxylic acid include fatty acids such as lauric acid, myristic acid, palmitic acid, and stearic acid, aromatic carboxylic acids such as benzoic acid, dicarboxylic acids such as tartaric acid and fumaric acid, and tricarboxylic acids such as citric acid.

[0019] The plasticizer other than the evaporative plasticizer is a plasticizer having a vapor pressure of less than 0.0001 mmHg at 20°C, and examples thereof include diisononyl adipate, azelaic acid, 2-ethylhexyl, and sebacic acid.

[0020] Examples of the stabilizer include epoxidized soybean oil, barium / zinc-based liquid stabilizer, and barium stearate.

[0021] For the adjustment of the anti-parasitic collar and the blister packaging container of the present invention, known methods described in Patent Document 1 and the like are applied. For example, the anti-parasitic collar is melt-kneaded with various components described above using a known kneader such as a plastograph mill, a Banbury mixer, or a super mixer, and then formed into a predetermined shape using a known injection molding machine such as an injection molding machine, an extrusion molding machine, or a press molding machine. After that, it can be manufactured by cutting as necessary and attaching fasteners such as buckles.

[0022] In addition, immediately after production, the anti-parasitic collar of the present invention is stored in a blister packaging container 1 composed of a mount 3 and a transparent blister member 4 as shown in FIG. 1, and is stored, transported, etc., and then displayed at the store.

[0023] The mount 3 has a three-layer structure in which a paper base material 5, a gas barrier layer 6, and a polyolefin layer 7 are laminated in this order. Examples of the paper base material include coated cardboard, carton paper, manila cardboard, and the like. Examples of the gas barrier layer include aluminum, polyethylene terephthalate, and the like. Examples of the polyolefin layer include L-LDPE. The paper base material and the gas barrier layer, as well as the gas barrier layer and the polyolefin layer, are adhered by an adhesive mainly composed of a vinyl acetate resin, an ethylene-vinyl acetate copolymer resin, an acrylic resin, or the like to form a mount having a three-layer structure.

[0024] The blister member 4 is composed of a storage portion 4a for storing the insect repellent collar and a flange portion 4b on a plane formed along the outer peripheral edge of the storage portion. This flange portion 4b includes an adhesive portion 4d that can be pressure-bonded to the mount to keep the storage portion 4a in a sealed state, and a handle portion 4c for peeling the blister member from the mount without adhering to the mount.

[0025] The blister member 4 is made of a thermoplastic resin having gas barrier properties and light transmissivity, and has a structure in which a film layer 8 and a PET layer 9 are adhered and laminated. The film layer is a layer for imparting ease of peeling from the polyolefin layer in the mount. For example, TAF610C manufactured by Toppan Printing Co., Ltd. can be used. The outermost PET layer is a layer for imparting gas barrier properties. For example, PT-700 of Polytech Co., Ltd. can be used.

[0026] After the insect repellent collar of the present invention is stored in the storage portion 4a of the blister member, the flange portion is heat-pressed, so that the film layer 8 in the blister member 4 and the polyolefin layer 7 in the mount 3 are thermally adhered. Thereby, the insect repellent collar can be stored in a sealed state in the blister packaging container.

[0027] Examples of pests that can be controlled by the insecticidal collar of the present invention include cryptids such as cat fleas, dog fleas, and human fleas; ticks such as Ixodes longicornis, Ixodes japonica, Ixodes japonica, and Ixodes schulzii; and diptera pests such as Asian tiger mosquitoes, Culex pipiens, Aedes aegypti, and Culex pipiens. [Examples]

[0028] The present invention will be specifically described below with reference to examples, but the present invention is not limited to these examples.

[0029] Thirteen anthelmintic collars were prepared according to the raw materials listed below, the formulation shown in Table 1, and the manufacturing procedure for anthelmintic collars described later. The values ​​shown in Table 1 are in weight percentages.

[0030] [Raw materials used] Raw material ingredient (A): Phenothrin (manufactured by Sumitomo Chemical Co., Ltd., product name: Smithrin) Raw material ingredient (B) Pyriproxyfen (manufactured by Sumitomo Chemical Co., Ltd., product name: Sumilab) Raw material ingredient (C) Triethyl phosphate (Kurogane Kasei Co., Ltd., product name: TEP) Raw material component (D) Diisodecyl adipate (Taoka Chemical Industries, Ltd., product name: DIDA) Raw material ingredient (E) Isostearic acid (Nissan Chemical Industries, Ltd.) Raw material ingredient (F): Epoxy soybean oil (ADEKA Corporation, product name: Adekaiser O-130P) Raw material component (G): Barium / zinc-based liquid stabilizer (Sakai Chemical Industry Co., Ltd., product name: LBZ-793K) Raw material component: (H) Rutile-type titanium dioxide (manufactured by Teika Co., Ltd., product name JR800, average particle size 0.27 μm) Raw material ingredient (I): Barium stearate (NOF Co., Ltd., product name: Barium stearate) Raw material component (J): Polyvinyl chloride resin (manufactured by Shin-Daiichi Vinyl Chloride Co., Ltd., product name: ZEST 1300Z)

[0031] [Table 1] TIFF2026066358000001.tif75131

[0032] [Manufacturing procedure for deworming collars] 1. After preheating raw material components (F) and (G) to 60°C, all raw material components (A) to (G) were mixed in a poly cup to obtain a mixed solution. 2. The raw material components (H), (I), and (J) were mixed uniformly in a separate poly cup to obtain a mixed powder. 3. A plastograph mill (manufactured by Toyo Seiki Seisakusho Co., Ltd.) was heated to 140°C, and the mixed powder was added while the rotor was rotated at 10 rpm. Then the mixed liquid was added, and the rotor speed was changed to 50 rpm. The mixture was melt-kneaded for 5 minutes to obtain a kneaded product. 4. Remove the kneaded mixture obtained above from the plastograph mill, sandwich it between two aluminum plates, and press it at a pressure of 50 kg / cm² using a tabletop test press machine (manufactured by Shinto Metal Industries Co., Ltd.). 2 Press for 1 minute, then apply an additional pressure of 100 kg / cm². 2 I pressed it for one minute. 5. Place the 27g pressed material obtained above into a molding frame measuring 15cm in length, 5cm in width, and 3mm in thickness, and press it using the aforementioned tabletop test press machine at a temperature of 160°C and a pressure of 100kg / cm². 2 The molded body was obtained by pressing it for 1 minute under these conditions. 6. Transfer the molded body obtained above to the water-cooled section of a tabletop test press machine and apply a pressure of 100 kg / cm². 2 The molded body was cooled to 35°C under these conditions, and the molded body was cut to a length of 15 cm, width of 1 cm, and thickness of 3 mm to obtain an insecticidal collar.

[0033] Ten of each type of anthelmintic collar obtained as described above were placed in the storage compartment of a blister component having the shape shown in Figure 1. Then, a cardboard backing was placed on the blister component, and the flange portion of the cardboard backing was heated and pressed to create a blister packaging container containing the anthelmintic collars. The aforementioned backing card was a three-layer structure consisting of a paper base made of coated cardboard with a thickness of 500 μm, a gas barrier layer made of polyethylene terephthalate with a thickness of 25 μm, and a polyolefin layer made of L-LDPE with a thickness of 30 μm. The aforementioned blister material was a two-layer structure consisting of a film layer made of TAF610C with a thickness of 25 μm and a PET layer with a thickness of 350 μm.

[0034] [Checking for breeding status] The blister packaging containers containing the antiparasitic collars obtained as described above were placed in a 60°C constant temperature bath, and after two months, they were removed and checked for the presence or absence of bleeding on the surface of the antiparasitic collars. The surface of the deworming collars inside the blister packaging was observed. Collars with visible droplets were classified as having bleed, while those without droplets were classified as not having bleed. Table 2 below shows the number of deworming collars in which bleed occurred.

[0035] [Table 2] TIFF2026066358000002.tif1186

[0036] [Measurement of bleed amount] Three of each of the antiparasitic collars prepared as described above were placed in a 35°C incubator for 16 days, and the phenothrin and pyriproxyfen that bled onto the surface of the collars over time were wiped off with paper wipes (Elleair® ProWipe Soft Wiper S200, manufactured by Daio Paper Corporation). Each of the paper rags used for wiping at each time interval and 50 ml of acetone were placed in a 60 ml screw-cap tube and irradiated with ultrasound for 30 minutes to extract phenothrin and pyriproxyfen, obtaining an extract. The amount of phenothrin contained in this extract was measured by liquid chromatography under the following measurement conditions, and the amount of phenothrin (μg / cm³) was determined. 2 The daily rate was calculated for each case, and the average was calculated. The results are shown in Table 3. The liquid chromatography measurement conditions are as follows: Mobile phase: Acetonitrile / distilled water mixture (80:20) Extraction volume: 5 μL Flow rate: 1.0mL / min Separation tube: ODS-A212 manufactured by Sumika Analysis Center Co., Ltd. Detector: Ultraviolet absorbance photometer (manufactured by Shimadzu Corporation) Detection wavelength: 272nm

[0037] [Table 3] TIFF2026066358000003.tif2980 [Brief explanation of the drawing]

[0038] [Figure 1] This is a perspective view showing a blister packaging container and the antiparasitic collar of the present invention housed in the container. [Figure 2] Figure 1 is an explanatory diagram illustrating the process of removing the insecticidal collar stored in the blister packaging container by peeling the flange portion of the blister component from the backing paper. [Figure 3] Figure 1 shows a cross-sectional view of the adhesive portion between the blister component and the backing card in the blister packaging container. [Explanation of Symbols]

[0039] 1. Blister packaging container 2. Deworming collar 3. Mounting board 4. Blister components 4a Storage area 4b Brim 4c Handle 4d adhesive part 5 Paper base material 6. Gas barrier layer 7. Polyolefin layer 8 film layers 9 PET layers

Claims

1. A deworming collar containing a vinyl chloride resin component, an active ingredient, a volatile plasticizer, and titanium dioxide, The active ingredient comprises one or more selected from the group consisting of phenothrin and pyriproxyfen. A deworming collar containing phenothrin, where the phenothrin content is in the range of 20 to 60% by weight relative to the vinyl chloride resin component.

2. The antiparasitic collar according to claim 1, wherein the titanium dioxide content, when phenothrin is included, is 0.03% to 10.00% by weight relative to the total content of phenothrin and the volatile plasticizer.

3. The deworming collar according to claim 1 or 2, wherein the titanium dioxide content is 0.01% to 1.00% by weight relative to the deworming collar.

4. The anthelmintic collar according to any one of claims 1 to 3, wherein the evaporative component comprises at least one selected from the group consisting of triethyl phosphate and tributyl phosphate.

5. The deworming collar according to any one of claims 1 to 4, wherein the deworming collar is stored in a sealed container.

6. The deworming collar according to claim 5, wherein the sealed container is a blister packaging container.

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