Allergen reducing agent

Abstract

This invention provides an allergen reducing agent that exhibits excellent allergen reduction effects. [Solution] The allergen reducing agent of the present invention is characterized by containing at least one cerium compound, which is either cerium oxide or cerium hydroxide. Therefore, it exhibits an excellent allergen reducing effect through the action of at least one cerium compound, which is either cerium oxide or cerium hydroxide, and in particular, it exhibits excellent water resistance in its allergen reducing effect. Furthermore, the allergen reducing agent of the present invention exhibits an excellent allergen reducing effect without requiring light irradiation and exhibits an excellent allergen reducing effect even in the dark.

Description

[Technical Field]

[0001] This invention relates to an allergen reducing agent. [Background technology]

[0002] In recent years, many allergic diseases such as atopic dermatitis, bronchial asthma, and allergic rhinitis have become a problem. The main cause of these allergic diseases is the increase in allergens in living spaces, such as dust mites that inhabit homes, particularly house dust mites (Der1, Der2), which are abundant in indoor dust, and cedar pollen allergens (Cry j1, Cry j2), which are mainly suspended in the air in large quantities during the spring.

[0003] The allergens from house dust mites are not the mites themselves, but rather their carcasses and feces. Therefore, eliminating house dust mites does not provide a fundamental solution to allergic diseases.

[0004] Furthermore, Cry j1 and Cry j2, which are cedar pollen allergens, are glycoproteins with molecular weights of approximately 40 kDa and 37 kDa, respectively, and have complex three-dimensional structures folded in a spiral or sheet-like manner. When these cedar pollen allergens adhere to the nasal mucosa, they are recognized as foreign substances outside the body and trigger an inflammatory response.

[0005] Therefore, there is a need for technologies that can remove allergens from living spaces or inactivate them by denaturing them.

[0006] Patent Document 1 discloses an interior decorative sheet having anti-allergen properties, wherein the surface protective layer comprises a pattern layer and a curable resin on a base sheet, and the surface protective layer is blended with an anionic phenolic material having anti-allergen properties and a zinc-based material having anti-allergen properties. [Prior art documents] [Patent Documents]

[0007]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0008] However, the allergen treatment ability (allergen reduction effect) of the anionic phenolic material and zinc-based material having allergen resistance used in the interior decorative sheet having allergen resistance disclosed in Patent Document 1 is insufficient, and an allergen reducing agent having an excellent allergen reduction effect is desired.

[0009] The present invention provides an allergen reducing agent having an excellent allergen reduction effect.

Means for Solving the Problems

[0010] The allergen reducing agent of the present invention is characterized by containing at least one cerium compound of cerium oxide and cerium hydroxide.

[0011] The allergen reducing paint of the present invention is characterized by including a paint and the allergen reducing agent contained in the paint.

[0012] The allergen reducing liquid of the present invention is characterized by including a solvent and the allergen reducing agent dispersed in the solvent.

[0013] The allergen reducing fiber of the present invention is characterized by including a fiber and the allergen reducing agent present on the surface of the fiber.

[0014] The allergen reducing fiber product of the present invention is characterized by including the allergen reducing fiber.

[0015] The allergen reduction method of the present invention is characterized by reducing the allergen by bringing the above-mentioned allergen reducing agent into contact with the allergen. [Effects of the Invention]

[0016] The allergen reducing agent of the present invention exhibits an excellent allergen reducing effect through the action of at least one cerium compound, either cerium oxide or cerium hydroxide, and in particular, its allergen reducing effect is highly water-resistant.

[0017] Furthermore, the allergen reducing agent of the present invention exhibits excellent allergen reducing effects without requiring light irradiation, and also exhibits excellent allergen reducing effects even in dark places. [Modes for carrying out the invention]

[0018] In the numerical ranges described stepwise in this specification, the upper or lower limit of one step in the numerical range can be arbitrarily combined with the upper or lower limit of another step in the numerical range. In the numerical ranges described in this specification, the upper or lower limit of that numerical range may be replaced with values ​​shown in the examples or values ​​that can be uniquely derived from the examples. In this specification, numbers connected by "~" mean a numerical range that includes the numbers before and after "~" as the lower and upper limits.

[0019] (Cerium compound) The allergen reducing agent of the present invention contains at least one cerium compound, selected from cerium oxide and cerium hydroxide [Ce(OH)4], as an active ingredient. The cerium compound may be used alone or in combination of two or more.

[0020] The cerium compound content in the allergen reducing agent is preferably 50% by mass or more, more preferably 60% by mass or more, more preferably 70% by mass or more, more preferably 80% by mass or more, more preferably 90% by mass or more, more preferably 95% by mass or more, more preferably 99% by mass or more, and more preferably 100% by mass.

[0021] The cerium oxide content in the cerium compound is preferably 50% by mass or more, more preferably 60% by mass or more, more preferably 70% by mass or more, more preferably 80% by mass or more, more preferably 90% by mass or more, more preferably 95% by mass or more, more preferably 99% by mass or more, and more preferably 100% by mass.

[0022] The cerium hydroxide content in the cerium compound is preferably 50% by mass or more, more preferably 60% by mass or more, more preferably 70% by mass or more, more preferably 80% by mass or more, more preferably 90% by mass or more, more preferably 95% by mass or more, more preferably 99% by mass or more, and more preferably 100% by mass.

[0023] In addition to cerium dioxide (CeO2), cerium oxide also exists as cerium trioxide (Ce2O3). However, cerium trioxide is unstable and is easily oxidized to cerium dioxide.

[0024] Cerium oxide generates cerium hydroxide when exposed to moisture supplied from an external source or moisture present in the atmosphere. The hydroxyl groups (-OH) bonded to the cerium atoms in this cerium hydroxide interact with allergens, thereby producing an allergen-reducing effect.

[0025] Cerium hydroxide [Ce(OH)4] exerts its allergen-reducing effect because the hydroxyl group (-OH) bonded to the cerium atom in its molecule interacts with allergens.

[0026] Here, in cerium oxide, some of the cerium oxide reacts with moisture on its solid surface to form a layer of cerium hydroxide. However, since the amount of cerium hydroxide layer is extremely small compared to the amount of cerium oxide, it is treated as "cerium oxide" in this invention.

[0027] It is presumed that cerium hydroxide, including cerium hydroxide formed on the surface of cerium oxide, forms a cross-linked structure through dehydration condensation between hydroxyl groups, and cerium compounds have excellent water resistance. Therefore, allergen-reducing products treated with the allergen-reducing agent described later have excellent water resistance and can maintain their excellent allergen-reducing effect even after water treatment such as washing.

[0028] Cerium oxide is preferably cerium oxide with cerium hydroxide formed on its surface, more preferably cerium oxide with cerium hydroxide formed entirely on its surface, more preferably cerium oxide with cerium hydroxide formed only on its surface, and most preferably cerium oxide with cerium hydroxide formed entirely only on its surface. In cerium oxide with cerium hydroxide formed on its surface, a water-resistant layer is formed by the cerium hydroxide on its surface, while cerium oxide exists inside the cerium hydroxide. Even if the cerium hydroxide layer formed on the surface decreases or disappears over time due to use, new cerium hydroxide is formed from the cerium oxide inside, forming a cerium hydroxide layer that exhibits an excellent allergen-reducing effect, and the allergen-reducing agent can maintain a stable and excellent allergen-reducing effect over a long period of time.

[0029] The cerium compound is preferably in particulate form. When the cerium compound is in particulate form, the surface area of ​​the cerium compound can be increased, improving the interaction between the cerium compound and the allergen and resulting in an excellent allergen reduction effect.

[0030] When the cerium compound is in particulate form, the D50 particle size of the cerium compound is preferably 0.001 μm or larger, more preferably 0.005 μm or larger, more preferably 0.01 μm or larger, more preferably 0.012 μm or larger, and more preferably 0.015 μm or larger. The D50 particle size of the cerium compound is preferably 150 μm or smaller, more preferably 100 μm or smaller, more preferably 80 μm or smaller, more preferably 60 μm or smaller, more preferably 40 μm or smaller, and more preferably 20 μm or smaller. By setting the D50 particle size of the cerium compound within the above range, the amount of hydroxyl groups present on the surface of the particulate cerium compound can be more appropriately adjusted, resulting in an even better allergen reduction effect.

[0031] When the cerium compound is in particulate form, the D90 particle size of the cerium compound is preferably 0.01 μm or larger, more preferably 0.015 μm or larger, more preferably 0.02 μm or larger, more preferably 0.025 μm or larger, and more preferably 0.03 μm or larger. The D90 particle size of the cerium compound is preferably 150 μm or smaller, more preferably 130 μm or smaller, more preferably 110 μm or smaller, more preferably 90 μm or smaller, more preferably 70 μm or smaller, and more preferably 50 μm or smaller. By setting the D90 particle size of the cerium compound within the above range, the inclusion of coarser particles compared to the average size of cerium compound particles is reduced, the amount of hydroxyl groups present on the surface of the particulate cerium compound can be more appropriately adjusted, and an even better allergen reduction effect can be achieved.

[0032] The D50 and D90 particle sizes of cerium compounds refer to the particle sizes at which the cumulative frequency (cumulative from smallest particles) in the volume-based particle size distribution measured by laser scattering method reaches 50% and 90%, respectively (50% cumulative particle size and 90% cumulative particle size).

[0033] (acidic compound) The allergen reducing agent preferably contains an acidic compound. When the allergen reducing agent contains an acidic compound, crosslink formation is promoted by accelerating the dehydration condensation between the hydroxyl groups of the cerium compound, and the water resistance of the allergen reducing effect of the allergen reducing agent is improved.

[0034] The acidic compound has an acidic functional group or its salt in the molecule. The acidic functional group refers to a functional group that can release hydrogen ions (protons) in an aqueous solution. The acidic functional group is not particularly limited, and examples thereof include a carboxy group (-COOH), a sulfo group (sulfonic acid group) (-SO3H), a phosphonic acid group [-P(=O)(OH)2], a phosphoric acid group [-OPO(OH)2], etc. Since the allergen reducing agent has an excellent allergen reducing effect, a carboxy group, a sulfo group, and a phosphonic acid group are preferred.

[0035] The salt of the carboxy group (-COOH) is not particularly limited, and examples thereof include a sodium salt (-COONa), a potassium salt (-COOK), a calcium salt [(-COO - )2Ca 2+ , an ammonium salt (-COO - NH4 + ), a magnesium salt [(-COO - )2Mg 2+ , a barium salt [(-COO - )2Ba 2+ , etc. A sodium salt is preferred.

[0036] The salt of the sulfo group (-SO3H) is not particularly limited, and examples thereof include a sodium salt (-SO3Na), a potassium salt (-SO3K), a calcium salt [(-SO3 - )2Ca 2+ , an ammonium salt (-SO3 - NH4 + ), a magnesium salt [(-SO3 - )2Mg 2+ , a barium salt [(-SO3 - )2Ba 2+ , etc. A sodium salt is preferred.

[0037] The salts of the phosphonic acid group [-P(=O)(OH)2] are not particularly limited, and include, for example, sodium salt [-P(=O)(ONa)2], potassium salt [-P(=O)(OK)2], and calcium salt [-P(=O)(OH)2]. - )2Ca 2+ ], ammonium salt [-P(=O)(O - NH4 + )2], magnesium salt [-P(=O)(O - )2Mg 2+ ], barium salt [-P(=O)(O - )2Ba 2+ Examples include:

[0038] The salts of the phosphate group [-OPO(OH)2] are not particularly limited, and include, for example, sodium salt [-OPO(ONa)2], potassium salt [-OPO(OK)2], and calcium salt [-OPO(O - )2Ca 2+ ], ammonium salt [-OPO(O - NH4 + )2], magnesium salt [-OPO(O - )2Mg 2+ ], barium salt [-OPO(O - )2Ba 2+ Examples include:

[0039] Acidic compounds having a carboxyl group or a salt thereof only need to have one or more carboxyl groups or salts thereof in their molecule, for example, adipic acid, benzoic acid, lauric acid, azelaic acid, sebacic acid, dodecanediic acid, fumaric acid, phthalic acid, isophthalic acid, terephthalic acid, methylenedisalicylic acid, cis-Δ4-tetrahydrophthalic acid, caproic acid, enanthic acid, caprylic acid, pelargonic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, myristoleic acid, oleic acid, li Examples include cinoleic acid, salicylic acid, gallic acid hydrate, benzyl acid, 4-aminobenzoic acid, triglycolamic acid, ethylenediaminetetraacetic acid, 1,3-diaminopropanetetraacetic acid, ethylenediaminesuccinic acid, diethylenetriaminepentaacetic acid, 1-amino-1-cyclobutanecarboxylic acid, cycloleucine, 1-aminocyclohexanecarboxylic acid, 3-aminocyclohexanecarboxylic acid, polymers having carboxyl groups in the side chains of linear polymers (e.g., polyacrylic acid), or salts of these compounds.

[0040] In polymers having a carboxyl group or a salt thereof in the side chain of a linear polymer, the linear polymer is not particularly limited, but for example, vinyl polymers, polyesters, and polyurethanes are preferred, and vinyl polymers are more preferred.

[0041] Examples of polymers having carboxyl groups in the side chains of linear polymers include polymers containing carboxyl group-containing monomers as monomer units. A polymer containing carboxyl group-containing monomers as monomer units may be a homopolymer of carboxyl group-containing monomers, or a copolymer of a carboxyl group-containing monomer and a monomer copolymerizable thereto.

[0042] The carboxyl group-containing monomer is not particularly limited, and examples include acrylic acid, methacrylic acid, β-carboxyethyl (meth)acrylate, 5-carboxypentyl (meth)acrylate, mono(meth)acryloyloxyethyl succinate, ω-carboxypolycaprolactone mono(meth)acrylate, crotonic acid, maleic acid, fumaric acid, itaconic acid, citraconic acid, and carboxybetaine-type monomers, with acrylic acid and methacrylic acid being preferred. The carboxyl group-containing monomer may be used alone or in combination of two or more types.

[0043] Examples of polymers having a carboxyl group salt in the side chain of a linear polymer include polymers containing a carboxyl group salt-containing monomer as monomer units. A polymer containing a carboxyl group salt-containing monomer as monomer units may be a homopolymer of carboxyl group salt-containing monomers, or a copolymer of a carboxyl group salt-containing monomer and a monomer copolymerizable thereto.

[0044] The monomers containing a carboxyl group salt are not particularly limited, and examples include salts of acrylic acid, methacrylic acid, mono(meth)acryloyloxyethyl succinate, ω-carboxypolycaprolactone mono(meth)acrylate, crotonic acid, maleic acid, fumaric acid, itaconic acid, citraconic acid, and carboxybetaine type monomers. Salts of acrylic acid are preferred, and sodium acrylate and potassium acrylate are more preferred. The monomers containing a carboxyl group salt may be used alone or in combination of two or more.

[0045] Acidic compounds containing a sulfo group (-SO3H) or a salt thereof only need to have one or more sulfo groups or salts thereof in the molecule. Examples include polymers having a sulfo group or a salt thereof in the side chain of a linear polymer, polystyrene sulfonic acid or its sulfonate, sulfonated (styrene-divinylbenzene copolymer) or its sulfonate, sulfonated polyethersulfone or its sulfonate.

[0046] In polymers having a sulfo group or a salt thereof in the side chain of a linear polymer, the linear polymer is not particularly limited, but for example, vinyl polymers, polyesters, and polyurethanes are preferred, and vinyl polymers are more preferred.

[0047] Examples of polymers having sulfo groups in the side chains of linear polymers include polymers containing sulfo group-containing monomers as monomer units.

[0048] Examples of polymers containing sulfo group-containing monomers as monomer units include polymers containing styrene sulfonic acid units, homopolymers of styrene sulfonic acid, styrene-styrene sulfonic acid copolymers, compounds in which the benzene ring of polystyrene is sulfonated, and compounds in which the benzene ring of a polymer containing a styrene component is sulfonated.

[0049] The monomers containing sulfo groups are not particularly limited, and examples include p-styrenesulfonic acid, m-styrenesulfonic acid, and o-styrenesulfonic acid.

[0050] Polymers having a sulfo salt in the side chain of a linear polymer are not particularly limited, and examples include polymers containing a sulfo salt-containing monomer containing a sulfo salt as a monomer unit.

[0051] Polymers containing a sulfo group salt-containing monomer as a monomer unit include, for example, polymers containing styrene sulfonate units, homopolymers of styrene sulfonate, styrene-styrene sulfonate copolymers, sulfonate salts of compounds in which the benzene ring of polystyrene is sulfonated, and sulfonate salts of compounds in which the benzene ring of a polymer containing a styrene component is sulfonated.

[0052] The monomer containing the sulfo group salt is not particularly limited, and examples include sodium p-styrenesulfonate, sodium m-styrenesulfonate, sodium o-styrenesulfonate, calcium p-styrenesulfonate, calcium m-styrenesulfonate, calcium o-styrenesulfonate, ammonium p-styrenesulfonate, ammonium m-styrenesulfonate, and ammonium o-styrenesulfonate. Sodium styrenesulfonate is preferred, and sodium p-styrenesulfonate is more preferred because it exhibits less steric hindrance in its reactivity with viruses.

[0053] Acidic compounds containing a sulfo group salt only need to have one or more sulfo group salts in their molecule. Examples include linear alkylbenzene sulfonates, α-olefin sulfonates, alkyldiphenyl ether sulfonates, polyoxyalkylene alkyl ether sulfates, polymers having sulfo group salts in the side chains of linear polymers, salts of polystyrene sulfonic acid, salts of sulfonated (styrene-divinylbenzene copolymers), and salts of sulfonated polyethersulfones.

[0054] As acidic compounds containing a sulfo group or a salt thereof, acidic compounds containing a benzene ring having a hydroxyl group and a sulfo group as substituents, and acidic compounds containing a benzene ring having a salt of a hydroxyl group and a sulfo group as substituents are preferred, and acidic compounds having the structures shown in the following formulas (1) to (3) are more preferred. The allergen reducing agent exhibits excellent water resistance in its allergen reducing effect.

[0055] [ka]

[0056] However, in equation (1), X 1 X is a countercation that becomes a hydrogen ion or a salt. In equation (2), X 2 X is a countercation that becomes a hydrogen ion or a salt. In equation (3), X 3 This is a countercation that becomes a hydrogen ion or a salt.

[0057] In equation (1), X 1 Examples include hydrogen ions, sodium ions, and potassium ions, with hydrogen ions and sodium ions being preferred. In formula (1), -SO3X 1 It is preferable that the compound is located at the meta or para position relative to the hydroxyl group (-OH). The allergen-reducing effect of the allergen-reducing agent has excellent water resistance.

[0058] In equation (2), X 2 Examples of such ions include hydrogen ions, sodium ions, and potassium ions, with potassium ions and sodium ions being preferred.

[0059] In equation (3), X 3 Examples of such ions include hydrogen ions, sodium ions, and potassium ions, with potassium ions and sodium ions being preferred.

[0060] The acidic compound containing a sulfo group or a salt thereof preferably has the structure shown in formula (4a), and more preferably has the structure shown in formula (4b). The allergen reducing effect of the allergen reducing agent has excellent water resistance.

[0061] [ka]

[0062] In equations (4a) and (4b), n is a repeating unit and is an integer greater than or equal to 2, and X 4 X is a countercation that becomes a hydrogen ion or a salt. 5 *1 is a countercation that becomes a hydrogen ion or a salt. *1 is a bonding hand and means a single bond.

[0063] X 4This is a countercation that becomes a hydrogen ion or a salt. The countercation that becomes a salt is not particularly limited, and examples include sodium ions, potassium ions, calcium ions, ammonium ions, magnesium ions, and barium ions, with sodium ions and potassium ions being preferred.

[0064] X 5 The countercation is either a hydrogen ion or a salt, with hydrogen ions being preferred. The salt-forming countercation is not particularly limited and includes, for example, sodium ions, potassium ions, calcium ions, ammonium ions, magnesium ions, and barium ions, with sodium ions and potassium ions being preferred.

[0065] The acidic compound having the structure shown in formula (4a) is preferably also having the structure shown in formula (5).

[0066] [ka]

[0067] In equation (5), m is a repeating unit and is an integer greater than or equal to 2. 6 X is a countercation that becomes a hydrogen ion or a salt. 6 *2 may be the same or different from each other. *2 is a bond and means a single bond.

[0068] X 6 The countercation is either a hydrogen ion or a salt, with hydrogen ions being preferred. The salt-forming countercation is not particularly limited and includes, for example, sodium ions, potassium ions, calcium ions, ammonium ions, magnesium ions, and barium ions, with sodium ions and potassium ions being preferred.

[0069] As the acidic compound, polymers having the structural unit shown in formula (6a) are preferred, polymers having the structural unit shown in formula (6b) are more preferred, polymers shown in formula (6c) are more preferred, and polymers shown in formula (6d) are more preferred. The allergen reducing effect of the allergen reducing agent has excellent water resistance.

[0070] [ka]

[0071] [ka]

[0072] In equations (6a) to (6d), n is a repeating unit and is an integer greater than or equal to 2, and m is a repeating unit and is an integer greater than or equal to 2. 4 X is a countercation that becomes a hydrogen ion or a salt. 5 X is a countercation that becomes a hydrogen ion or a salt. 6 X is a countercation that becomes a hydrogen ion or a salt. 6 These may be identical or different from one another. *3 is a bond and represents a single bond.

[0073] In equations (6a) to (6d), X 4 It is preferable that is a sodium ion or a potassium ion. In formulas (6a) to (6d), X 5 It is preferable that is a hydrogen ion. In equations (6a) to (6d), X 6 It is preferable that it be a hydrogen ion.

[0074] In this invention, the structural formula shown in formula (7) below represents a random copolymer, alternating copolymer, or block copolymer of monomer units M1 and M2. d, e, and f represent repeating units and are integers of 2 or more.

[0075] [ka]

[0076] Acidic compounds having a phosphonic acid group [-P(=O)(OH)2] only need to have one or more phosphonic acid groups in the molecule. Examples include 1-hydroxyethane-1,1-diphosphonic acid, N,N,N',N'-ethylenediaminetetrakis (methylenephosphonic acid), 2-phosphonobutane-1,2,4-tricarboxylic acid, nitrilotris (methylenephosphonic acid), and polymers having phosphonic acid groups in the side chains of linear polymers.

[0077] In polymers having phosphonic acid groups in the side chains of linear polymers, the linear polymer is not particularly limited, but for example, vinyl polymers, polyesters, and polyurethanes are preferred, and vinyl polymers are more preferred.

[0078] Examples of polymers having phosphonic acid groups in the side chains of linear polymers include polymers containing phosphonic acid group-containing monomers as monomer units. A polymer containing phosphonic acid group-containing monomers as monomer units may be a homopolymer of phosphonic acid group-containing monomers, or a copolymer of a phosphonic acid group-containing monomer and a monomer copolymerizable therewith.

[0079] The monomer containing the phosphonic acid group is not particularly limited, and examples include [3-(acryloyloxy)propyl]phosphonic acid. The monomer containing the phosphonic acid group may be used alone or in combination of two or more types.

[0080] Acidic compounds containing a phosphonic acid salt only need to have one or more phosphonic acid salts in their molecule. Examples include ethylenediaminetetramethylenephosphonate pentasodium, alkylphosphonate sodium, alkylbenzenephosphonate sodium, and polymers having a phosphonic acid salt in the side chain of a linear polymer.

[0081] In polymers having a phosphonic acid salt in the side chain of a linear polymer, the linear polymer is not particularly limited, but vinyl polymers, polyesters, and polyurethanes are preferred, with vinyl polymers being more preferred.

[0082] Examples of polymers having a phosphonic acid salt in the side chain of a linear polymer include polymers containing a phosphonic acid salt-containing monomer as a monomer unit. A polymer containing a phosphonic acid salt-containing monomer as a monomer unit may be a homopolymer of the phosphonic acid salt-containing monomer, or a copolymer of a phosphonic acid salt-containing monomer and a monomer copolymerizable thereto.

[0083] Acidic compounds having a phosphate group or a salt thereof only need to have one or more phosphonic acid groups in the molecule, and examples include (di)alkyl phosphate esters, (di)polyoxyalkylene alkyl ether phosphate esters, polyoxyalkylene alkylaryl ether phosphate esters, or salts of these compounds.

[0084] Polymers having at least one acidic functional group selected from the group consisting of carboxyl groups (-COOH), sulfo groups (-SO3H), phosphonic acid groups [-P(=O)(OH)2] and phosphate groups [-OPO(OH)2], or a salt thereof, in the side chains of linear polymers can be produced by general methods, for example: (1) a method of radical polymerization of a monomer having an acidic functional group or a salt thereof; (2) a method of radical polymerization of a monomer having an acidic functional group or a salt thereof with a monomer copolymerizable with this monomer; and (3) a method of neutralizing the acidic functional group of a polymer containing a monomer component having an acidic functional group using an alkali (e.g., sodium hydroxide, calcium hydroxide, potassium hydroxide, ammonium hydroxide, etc.).

[0085] When the acidic compound is a polymer, the weight-average molecular weight of the acidic compound is preferably 2000 or more, more preferably 5000 or more, and more preferably 10000 or more. The weight-average molecular weight of the acidic compound is preferably 250000 or less, more preferably 100000 or less, more preferably 50000 or less, more preferably 30000 or less, and more preferably 20000 or less. When the weight-average molecular weight of the acidic compound is 2000 or more, the sulfo group or its salt bonded to the aromatic ring can be arranged in a linked state with the hydroxyl group or its salt, allowing for effective interaction with the allergen. Therefore, the allergen reducing agent exhibits a superior allergen reducing effect. When the weight-average molecular weight of the acidic compound is 250000 or less, the allergen reducing effect of the allergen reducing agent has excellent water resistance.

[0086] In this invention, the weight-average molecular weight of the polymer is the polystyrene-converted value measured by GPC (gel permeation chromatography). When multiple peak tops are detected by GPC, the area value of each peak is considered as a weight to calculate the weight-average molecular weight, and this value is taken as the weight-average molecular weight of the polymer.

[0087] For example, measurements can be taken using the following measuring device and conditions. Gel permeation chromatograph: Waters Corporation, product name "Alliance HPLC" Column: Manufactured by Resonaq Corporation, product name "OHpak SB-805" Detector: Differential refractometer Sample flow rate: 1 mL / min Column temperature: 40℃ Elutate: 0.2M Na2CO3aq. 60 vol% / Acetonitrile 40 vol%

[0088] The content of the acidic compound in the allergen reducing agent is preferably 10 parts by mass or more, more preferably 30 parts by mass or more, more preferably 50 parts by mass or more, more preferably 70 parts by mass or more, and more preferably 90 parts by mass or more, per 100 parts by mass of the cerium compound. The content of the acidic compound in the allergen reducing agent is preferably 300 parts by mass or less, more preferably 200 parts by mass or less, more preferably 150 parts by mass or less, more preferably 120 parts by mass or less, and more preferably 110 parts by mass or less, per 100 parts by mass of the cerium compound. When the acidic compound is 10 parts by mass or more, the allergen reducing effect of the allergen reducing agent has excellent water resistance. When the acidic compound is 300 parts by mass or less, a cross-linked structure can be formed by dehydrating and condensing some of the hydroxyl groups of the cerium compound while leaving some of the hydroxyl groups intact, thereby imparting an excellent allergen reducing effect to the allergen reducing agent, and the allergen reducing effect has excellent water resistance.

[0089] [Allergen reducing agent] Allergen reducing agents have an allergen-reducing effect against various allergens through the action of cerium compounds.

[0090] Allergens targeted by allergen reducing agents include animal allergens such as dust mite allergens (Der1, Der2), allergens caused by dogs and cats (Can f1, Fel d1), and plant allergens such as cedar pollen allergens (Cryj1, Cryj2) and pollen that float in the air. While any type of mite allergen can be targeted, particularly those found in indoor dust, especially bedding, and are a common cause of allergic diseases, this product is especially effective against house dust mites, particularly house dust mites, which are abundant in indoor dust and bedding. It is particularly effective against house dust mites, which are a common cause of allergic diseases. (These include mites with dorsal spiracles, mites with tetraspiracles, mites with posterior spiracles, mites with posterior spiracles, mites with mesospiracles, mites with mesospiracles, mites with anterior spiracles, mites with stag beetle mites and broad mites, house dust mites such as Dermatophagoides pteronyssinus, mites with anaspiracles, and mites with hidden spiracles, such as house dust mites and ornamental red dust mites.)

[0091] Here, an allergen reducing agent refers to a substance that has an allergen reducing effect. The allergen reducing effect can be determined by measuring the allergen reduction rate of cedar pollen allergen (Cryj1) or dust mite allergen (Derf1) in the following manner, and if the allergen reduction rate for at least one of the allergens is 60% or higher, it can be determined that the substance has an allergen reducing effect.

[0092] The allergen-reducing effect of an allergen-reducing agent is measured, for example, in the following manner: An allergen-reducing coating is prepared by adding 90 parts by mass of binder resin as solid content to 10 parts by mass of allergen-reducing agent. Next, a polyester film is prepared as a substrate. After coating one side of this substrate with the allergen-reducing coating, the coating is dried or cured to produce an allergen-reducing product in which a coating film with a thickness of 18 μm is formed on one side.

[0093] Each of the above allergens is dissolved separately in purified water to prepare an allergen aqueous solution containing 10 μg / mL of the allergen. Then, 0.05 w / v% polysorbate 20-containing phosphate-buffered saline (pH: 7.4, hereinafter referred to as "PBS-T") is added to the allergen aqueous solution and mixed uniformly to prepare an allergen solution containing 15 ng / mL of the allergen.

[0094] The above allergen-reducing product is cut into a flat square with sides of 5 cm, 0.4 mL of the above allergen solution is dropped onto the coating, and then the product is covered with a flat square polyethylene film with sides of 4 cm and left at 25°C for 24 hours to prepare the test solution. Next, the amount of allergen present in the test solution W1 (ng / mL) is measured using the above measurement reagent.

[0095] A blank product with a coating formed on one side is prepared in the same manner as above, except that a binder resin is used as the blank coating instead of the allergen-reducing coating. The amount of allergen W0 (ng / mL) present in the test solution is measured in the same manner as above, except that a blank product is used instead of the allergen-reducing product. The allergen reduction rate (%) is calculated based on the following formula. Allergen reduction rate (%) = 100 - (W1 / W0) × 100

[0096] For example, as the cedar pollen allergen (Cryj1), you can use the product commercially available from ITEA under the product name "Cedar Pollen Extract, Code 4-CJ-001". For the dust mite allergen (Derf1), you can use the product commercially available from ITEA under the product name "Dust Mite Allergen Extract, Code 4-DF-001".

[0097] The allergen reduction rate of the allergen reducing agent is preferably 40% or more, more preferably 45% or more, more preferably 50% or more, more preferably 60% or more, preferably 70% or more, more preferably 80% or more, more preferably 85% or more, more preferably 90% or more, and more preferably 95% or more.

[0098] The method for producing an allergen reducing agent is not particularly limited. For example, an allergen reducing agent can be produced by mixing a cerium compound, which is the active ingredient, with a general-purpose additive as needed, in a general manner.

[0099] This document explains the usage instructions for allergen reducing agents. Allergen reducing agents exert an allergen-reducing effect against various allergens through the action of cerium compounds. By coming into contact with allergens, allergen reducing agents inactivate them, thereby reducing their levels.

[0100] Allergen reducing agents are used, for example, by being incorporated into a substrate to which an allergen reducing effect is desired, thereby constituting an allergen-reducing product. A substrate containing an allergen reducing agent exhibits an allergen-reducing effect as an allergen-reducing product. The form in which the allergen reducing agent is incorporated into the substrate is not particularly limited, and examples include mixing the allergen reducing agent into the substrate, attaching the allergen reducing agent to the surface of the substrate, or kneading the allergen reducing agent into the substrate.

[0101] By dispersing an allergen-reducing agent in a solvent to form an allergen-reducing solution, and then coating this allergen-reducing solution onto a substrate, the allergen-reducing agent can be adhered to the substrate surface. The allergen-reducing solution may also contain additives such as oils, emulsions, and suspensions, as needed.

[0102] Examples of the solvents mentioned above include water (preferably deionized water), alcohols (methyl alcohol, ethyl alcohol, propyl alcohol, etc.), hydrocarbons (toluene, xylene, methylnaphthalene, kerosene, cyclohexane, etc.), ethers (diethyl ether, tetrahydrofuran, dioxane, etc.), ketones (acetone, methyl ethyl ketone, etc.), and amides (N,N-dimethylformamide, etc.), with water being preferred.

[0103] The content of the allergen reducing agent in 100% by mass of the allergen reducing solution is preferably 0.01% by mass or more, more preferably 0.1% by mass or more, and more preferably 1% by mass or more. The content of the allergen reducing agent in 100% by mass of the allergen reducing solution is preferably 20% by mass or less, more preferably 15% by mass or less, and more preferably 10% by mass or less.

[0104] The substrates for which the allergen reducing agent is contained are not particularly limited as long as they can contain the allergen reducing agent, and examples include synthetic resin molded articles, paints, wallpaper, decorative sheets, flooring materials, fibers, textile products (woven fabrics, nonwoven fabrics, knitted fabrics, cloths), interior accessories and interior materials for vehicles (e.g., cars, airplanes, ships, etc.) (seats, child seats and the foams that make them up, etc.), kitchenware, baby products, and building interior materials.

[0105] The synthetic resin constituting the molded synthetic resin article is not particularly limited and includes, for example, thermoplastic resins (e.g., polyethylene, polypropylene, polyvinyl chloride, polystyrene, polyvinyl acetate, polyurethane, Teflon®, acrylonitrile butadiene styrene resin, acrylonitrile styrene resin, acrylic resin, polyvinyl alcohol, polyamide, polyacetal, polycarbonate, modified polyphenylene ether, polyester, polyethylene terephthalate, polybutylene terephthalate, cyclic polyolefin, polyphenylene sulfide, polytetrafluoroethylene, polysulfone, polyethersulfone, polyarylate, polyetheretherketone, thermoplastic polyimide, polyamideimide, etc.) and thermosetting resins (e.g., phenolic resin, epoxy resin, melamine resin, urea resin, unsaturated polyester resin, alkyd resin, silicone resin, polyurethane, thermosetting polyimide, etc.). The synthetic resin may be used alone or in combination of two or more types.

[0106] The allergen reducing agent may be kneaded into the synthetic resin. One method of kneading the allergen reducing agent into the synthetic resin is to mix the allergen reducing agent with the raw material synthetic resin to create a resin composition. Using this resin composition, an allergen-reducing product of the desired shape can be obtained as a molded article by a general-purpose synthetic resin molding method. Examples of general-purpose synthetic resin molding methods include extrusion molding, injection molding, and blow molding. Alternatively, the synthetic resin and the allergen reducing agent may be mixed to form a masterbatch for synthetic resin molding, which can then be mixed with the raw material synthetic resin to produce a molded allergen-reducing product using a general-purpose synthetic resin molding method.

[0107] The content of the allergen reducing agent in 100% by mass of the resin composition is preferably 1% by mass or more, more preferably 3% by mass or more, and more preferably 5% by mass or more. The content of the allergen reducing agent in 100% by mass of the resin composition is preferably 20% by mass or less, more preferably 15% by mass or less, and more preferably 10% by mass or less.

[0108] The content of the allergen reducing agent in 100% by mass of the masterbatch for molding synthetic resin is preferably 20% by mass or more, more preferably 30% by mass or more, and more preferably 50% by mass or more. The content of the allergen reducing agent in 100% by mass of the masterbatch for molding synthetic resin is preferably 80% by mass or less, more preferably 70% by mass or less, and more preferably 60% by mass or less.

[0109] This section describes a method for producing allergen-reducing fibers by physically fixing an allergen-reducing agent to fibers. Examples of methods for physically fixing an allergen-reducing agent to fibers include: (1) dispersing the allergen-reducing agent in a solvent (preferably water) to prepare an allergen-reducing solution, impregnating the fibers in this solution, and fixing the allergen-reducing agent to the fibers; (2) applying or spraying the above allergen-reducing solution onto the fiber surface; (3) immersing the fibers in a binder resin containing the above allergen-reducing agent, thereby fixing the allergen-reducing agent to the fibers with the binder resin; and (4) applying or spraying the above allergen-reducing agent in a binder resin onto the fiber surface, thereby fixing the allergen-reducing agent to the fibers with the binder resin. By using textile products as the fibers, allergen-reducing textile products can be produced. Furthermore, in the methods described in (1) and (2) above, a binder resin may be included in the allergen reduction solution. The solvent is the same as described above, so its explanation is omitted.

[0110] The binder resin is not particularly limited as long as it can fix the allergen reducing agent to the fiber surface. For example, examples of binder resins include urethane resins such as one-component urethane resins and two-component urethane resins, silicone resins, acrylic resins, urethane acrylate resins, polyester resins, unsaturated polyester resins, alkyd resins, vinyl acetate resins, vinyl chloride resins, epoxy resins, and epoxy acrylate resins, with urethane resins and polyester resins being preferred.

[0111] The method described in (1) above will be explained in detail. An allergen-reducing solution is prepared by dispersing an allergen-reducing agent in water. If the cerium compound contained in the allergen-reducing agent is cerium oxide, the surface of the cerium oxide reacts with water to produce cerium oxide having a layer of cerium hydroxide on its surface. Cerium hydroxide and cerium oxide having a layer of cerium hydroxide on its surface can be easily dispersed in water, and an allergen-reducing solution with excellent storage stability can be prepared.

[0112] The fibers are immersed in the allergen-reducing solution described above to impregnate them with the solution. Subsequently, the allergen-reducing solution is dried to evaporate and remove the water contained in it, at which point the cerium compound forms a water-resistant film on the surface of the fibers. At this time, it is presumed that some of the hydroxyl groups of cerium hydroxide undergo dehydration condensation to form a cross-linked structure. This film adheres firmly to the fibers and has excellent water resistance, remaining stably on the fiber surface even after water treatment such as washing, and can provide an excellent allergen-reducing effect.

[0113] The content of the cerium compound in the allergen-reducing solution is preferably 0.01 parts by mass or more, more preferably 0.02 parts by mass or more, and even more preferably 0.03 parts by mass or more, per 100 parts by mass of water. The content of the cerium compound in the allergen-reducing solution is preferably 10 parts by mass or less, more preferably 8 parts by mass or less, and even more preferably 5 parts by mass or less, per 100 parts by mass of water. When the cerium compound is 0.01 parts by mass or more, an excellent allergen-reducing effect can be imparted to the fibers. When the cerium compound is 10 parts by mass or less, the cerium compound can be uniformly dispersed in the allergen-reducing solution, a uniform film formed from the cerium compound can be formed on the surface of the fibers, and an excellent allergen-reducing effect can be uniformly imparted to the fibers.

[0114] The amount of cerium compound to be contained in the fiber is preferably 0.01 parts by mass or more, more preferably 0.02 parts by mass or more, and more preferably 0.03 parts by mass or more, per 100 parts by mass of fiber. The amount of cerium compound to be contained in the fiber is preferably 10 parts by mass or less, more preferably 8 parts by mass or less, and more preferably 5 parts by mass or less, per 100 parts by mass of fiber.

[0115] The amount of cerium compound to be included in the fabric is 0.01 g / m². 2 The above is preferable, and 0.02 g / m 2 The above is more preferable, 0.03 g / m 2The above is more preferable. The amount of cerium compound to be contained in the fabric is 5 g / m 2 The following is preferable: 3 g / m 2 The following is more preferable: 1 g / m 2 The following are preferable.

[0116] Allergen-reducing paints can be manufactured by incorporating allergen-reducing agents into the paint. The paint film produced from these allergen-reducing paints exhibits excellent allergen-reducing effects.

[0117] Conventional paints are used as coatings, including oil-based paints (e.g., mixed paints, oil varnishes, etc.), cellulose paints, synthetic resin paints, and water-based paints. Paints also include photocurable paints that polymerize upon irradiation with ultraviolet light or other radiation to produce binder resin components. Water-based paints contain the water-based solvent and binder resin described later.

[0118] The paint contains a binder resin, but this binder resin is not particularly limited as long as it can fix the allergen reducing agent to the substrate surface. Examples of binder resins include urethane resins such as one-component urethane resins and two-component urethane resins, silicone resins, acrylic resins, urethane acrylate resins, polyester resins, unsaturated polyester resins, alkyd resins, vinyl acetate resins, vinyl chloride resins, epoxy resins, and epoxy acrylate resins, with vinyl chloride resins being preferred.

[0119] Paints may contain additives such as pigments, plasticizers, hardeners, fillers, antioxidants, thickeners, and surfactants, to the extent that they do not impair the physical properties of the paint. Methods for producing allergen-reducing paints by incorporating allergen-reducing agents into the paint include, for example, supplying the allergen-reducing agent and the paint to a dispersion device and mixing them uniformly. Examples of dispersion devices include high-speed mills, ball mills, and sand mills.

[0120] The paint may contain a solvent to adjust its viscosity. The solvent may be either an aqueous solvent or an organic solvent, but an organic solvent is preferred because it improves the dispersibility of the allergen reducing agent in the paint. The organic solvent is not particularly limited and includes, for example, toluene, xylene, methyl ethyl ketone, acetone, ethyl acetate, and benzene. The aqueous solvent is not particularly limited and includes, for example, water and lower alcohols (alcohols with 4 or fewer carbon atoms, such as methanol, ethanol, propanol, and butanol), with a preferred aqueous medium containing 50% by mass or more of water. The organic solvent and aqueous solvent may be used individually or in combination of two or more.

[0121] The content of the allergen reducing agent in 100% by mass of the allergen-reducing paint is preferably 0.01% by mass or more, more preferably 0.1% by mass or more, and more preferably 1% by mass or more. The content of the allergen reducing agent in 100% by mass of the allergen-reducing paint is preferably 20% by mass or less, more preferably 15% by mass or less, and more preferably 10% by mass or less.

[0122] Building interior materials are not particularly limited and can include, for example, flooring, wallpaper, ceiling materials, paint, doorknobs, switches, switch covers, and wax.

[0123] Vehicle interior accessories and vehicle interior materials are not particularly limited and may include, for example, seats, child seats, seat belts, car mats, seat covers, doors, ceiling materials, floor mats, door trims, instrument panels, consoles, glove boxes, straps, handrails, etc. [Examples]

[0124] The present invention will be described more specifically below with reference to examples, but the present invention is not limited thereto. Specific numerical values ​​such as blending ratios (content percentages), physical properties, and parameters used in the following description may be replaced with the corresponding upper limits (numerical values ​​defined as "less than or equal to" or "less than") or lower limits (numerical values ​​defined as "greater than or equal to") of the blending ratios (content percentages), physical properties, and parameters described in the "Means for Solving the Problems" and "Modes for Carrying Out the Invention" sections.

[0125] The following cerium compounds, other compounds, and acidic compounds were prepared. Cerium-3 and 4 oxides, and cerium-1 hydroxide were pulverized using a jet mill (SJ-500, manufactured by Nisshin Engineering Co., Ltd.) under various feed rates and a compressed air pressure of 0.75 MPa to obtain cerium compound particles. [Cerium oxide] Cerium oxide-1 (cerium oxide (CeO2), particulate, manufactured by Taki Chemical Co., Ltd., product name "Needral B-10", D50 particle size: 0.015 μm, D90 particle size: 0.04 μm) Cerium-2 oxide (cerium oxide (CeO2), particulate, manufactured by Daiichi Rare Elements Chemical Co., Ltd., product name "CESL-16", D50 particle size: 0.018 μm, D90 particle size: 0.03 μm) Cerium-3 oxide (cerium oxide (CeO2), particulate, manufactured by Fujifilm Wako Co., Ltd., D50 particle size: 1 μm, D90 particle size: 3.2 μm, jet mill supply rate: 0.2 kg / h) Cerium-4 oxide (cerium oxide (CeO2), particulate, manufactured by Fujifilm Wako Co., Ltd., D50 particle size: 18 μm, D90 particle size: 40 μm, jet mill supply rate: 1 kg / h)

[0126] [Cerium hydroxide] Cerium hydroxide-1 (Ce(OH)4, particulate, manufactured by Fujifilm Wako Co., Ltd., D50 particle size: 1 μm, D90 particle size: 3.3 μm, jet mill feed rate: 0.2 kg / h)

[0127] [Acidic compounds] • Sodium p-phenolsulfonate ·Sodium m-phenolsulfonate • Potassium hydroquinone sulfonate ·4,5-Dihydroxy-1,3-Benzenedisulfonate disodium • p-phenolsulfonic acid • Pentasodium ethylenediaminetetramethylenephosphonate Sodium polyacrylate • Acidic compound 1 (manufactured by Konishi Chemical Industry Co., Ltd., product name "WSR-SP82", aqueous solution with 32.3% by mass of the active ingredient, weight-average molecular weight: 10000, formula (6e), m and n are repeating units and integers of 2 or more.)

[0128] [ka]

[0129] (Examples 1-14, Comparative Example 1) An allergen reducing agent was prepared by uniformly mixing cerium compounds and acidic compounds in the predetermined amounts (parts by mass) shown in Table 1.

[0130] The allergen reduction rate (allergen reduction effect) of the obtained allergen reducing agent was measured according to the following procedure, and the results are shown in Tables 1 and 2.

[0131] [Paint film (water-based paint)] Freeze-dried dust mite allergen (Derf1) (manufactured by ITEA, product name "Dust Mite Allergen Extract, code 4-DF-001") and freeze-dried pollen allergen (Cryj1) (manufactured by ITEA, product name "Japanese Cedar Pollen Extract, code 4-CJ-001") were prepared.

[0132] We prepared reagents for measuring the abundance of dust mite allergen (Derf1) (ITEA Corporation, product name "Derf1 Dust Mite Allergen ELISA Kit, code 1-DF1-001") and pollen allergen (Cryj1) (ITEA Corporation, product name "Cryptomeria japonica Pollen Allergen (Cryj1) ELISA Kit, code 1-CJ-001").

[0133] To 10 parts by mass of the obtained allergen-reducing agent, a binder resin (Resonac Co., Ltd., product name "Polysol AM-200", solvent: water, solids content: 40% by mass) was added to a total of 90 parts by mass as solids to prepare an allergen-reducing coating. Next, a polyester film was prepared as a substrate. The allergen-reducing coating was applied to one side of this substrate to a film thickness of 18 μm after drying, and then dried in an oven at 120°C for 1 hour to produce an allergen-reducing product with a coating film formed on one side.

[0134] The freeze-dried powder of the above allergen was dissolved in purified water to prepare an allergen aqueous solution containing 10 μg / mL of the allergen. Then, PBS-T (phosphate buffer containing 0.05% by mass of Tween 20 (manufactured by Tokyo Chemical Industry Co., Ltd.), pH: 7.4) was added to the allergen aqueous solution and mixed uniformly to prepare an allergen solution containing 15 ng / mL of the allergen.

[0135] The above allergen-reducing product was cut into a flat square with sides of 5 cm, 0.4 mL of the above allergen solution was dropped onto the coating, and then the product was covered with a flat square polyethylene film with sides of 4 cm and left at 25°C for 24 hours to prepare the test solution. Next, the amount of allergen W1 (ng / mL) in the test solution was measured using the above measurement reagent.

[0136] A blank product with a coating formed on one side was prepared in the same manner as above, except that a binder resin (Resonac Co., Ltd., product name "Polysol AM-200", solvent: water, solids content: 40% by mass) was used as the blank coating instead of the allergen-reducing coating. The amount of allergen present in the test solution W0 (ng / mL) was measured in the same manner as above, except that a blank product was used instead of the allergen-reducing product. The allergen reduction rate (%) was calculated based on the following formula. Allergen reduction rate (%) = 100 - (W1 / W0) × 100

[0137] [Cloth (initial)] The same dust mite allergen (Derf1), pollen allergen (Cryj1), and measurement reagents used were those used in the above-mentioned [coating film (water-based paint)].

[0138] Purified water was added to 1 g of the obtained allergen reducing agent and mixed uniformly to prepare an allergen reducing agent dispersion containing 1% by mass of the allergen reducing agent.

[0139] Next, as the base material, we used polyester fabric (woven fabric, manufactured by Irozome Co., Ltd., product name "Polyester Tropical Toray", weight: 120g / m²). 2 A polyester cloth was prepared. The polyester cloth was immersed in 100g of the allergen reducing agent dispersion for 2 minutes. The immersed polyester cloth was squeezed with a manual mangle and dried at 120°C for 10 minutes to produce an allergen-reducing cloth in which the allergen reducing agent was fixed to the polyester fibers. In the allergen-reducing cloth, the allergen reducing agent was 1g / m 2 It was found to be contained. A cerium compound coating was formed on the surface of the polyester fibers of the allergen-reducing fabric.

[0140] The freeze-dried powder of the above allergen was dissolved in purified water to prepare an allergen aqueous solution containing 10 μg / mL of the allergen. Then, PBS-T (phosphate buffer containing 0.05% by mass of Tween 20 (manufactured by Tokyo Chemical Industry Co., Ltd.), pH: 7.4) was added to the allergen aqueous solution and mixed uniformly to prepare an allergen solution containing 15 ng / mL of the allergen.

[0141] 0.4 g of allergen-reducing cloth was placed in a resealable plastic bag, 1 mL of the above allergen solution was added dropwise, and the bag was sealed and left at 25°C for 2 hours to prepare the test solution.

[0142] Next, the amount of allergen W1 (ng / mL) present in the test solution was measured using the above-mentioned measurement reagent.

[0143] Except for not placing the allergen-reducing cloth in a resealable plastic bag, the amount of allergen present in the test solution W0 (ng / mL) was measured in the same manner as described above. The allergen reduction rate (%) was calculated based on the following formula. Allergen reduction rate (%) = 100 - (W1 / W0) × 100

[0144] [Fabric (after washing)] An allergen-reducing fabric was prepared using the same procedure as described above for the [Initial Fabric]. The following washing tests were performed on the obtained allergen-reducing fabric.

[0145] (Washing test) ·washing machine A fully automatic washing machine conforming to the Type C standard washing machine - vertical shaft, top-loading type (pulsator type) specified in JIS L 1930 was used. ·detergent JAFET standard detergent (containing polyoxyethylene alkyl ether and sodium alpha-olefin sulfonate) was used. ·Load cloth Type III polyester load fabric as specified in Annex H of JIS L 1930 was used. • Washing machine power The washing method conforms to the conditions of C4G specified in JIS L 1930 Annex F. • Washing instructions (1) The washing was carried out under the washing conditions with the washing machine power adjusted as described above. (2) Add 40 mL of JAFET standard detergent to 30 L of water to make a washing solution, and wash the fabric five times consecutively. After that, the allergen-reducing fabric was dried at a temperature of 80°C or lower.

[0146] The allergen reduction rate of the allergen-reducing fabric after washing was measured in the same manner as for the [original fabric].

[0147] [Dark place] Using the allergen-reducing agents of Examples 1 and 4, allergen-reducing products were prepared in the same manner as described above for [Fabric (Initial)].

[0148] In a dark place where no light was incident, the allergen reduction rate of the obtained allergen-reducing product was measured in the same manner as described above for [Cloth (Initial)].

[0149] [Table 1]

[0150] [Table 2]

Claims

1. An allergen reducing agent characterized by containing at least one cerium compound, which is either cerium oxide or cerium hydroxide.

2. The allergen reducing agent according to claim 1, characterized in that the cerium compound is in particulate form.

3. The allergen reducing agent according to claim 1 or 2, characterized in that the D50 particle size of the cerium compound is 0.001 to 20 μm.

4. The allergen reducing agent according to claim 1 or 2, further comprising an acidic compound having an acidic functional group or a salt thereof in its molecule.

5. The allergen reducing agent according to claim 4, characterized in that the acidic functional group is a sulfo group.

6. An allergen-reducing paint characterized by comprising a paint and an allergen-reducing agent contained in the paint according to claim 1 or claim 2.

7. An allergen-reducing liquid characterized by comprising a solvent and an allergen-reducing agent according to claim 1 or claim 2, dispersed in the solvent.

8. An allergen-reducing fiber characterized by comprising a fiber and an allergen-reducing agent according to claim 1 or claim 2 present on the surface of the fiber.

9. The allergen-reducing fiber according to claim 8, characterized in that the surface of the fiber has a coating of a cerium compound.

10. An allergen-reducing fiber product characterized by containing the allergen-reducing fiber described in claim 8.

11. An allergen reduction method characterized by reducing the allergen by bringing the allergen-reducing agent described in claim 1 or claim 2 into contact with the allergen.

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