Agents used for treating tissue damage

Small molecule CRP-binding inhibitors form stable complexes with CRP to prevent complement activation, reducing tissue damage and disease severity in conditions like myocardial infarction and stroke.

JP2026086392APending Publication Date: 2026-05-26UCL BUSINESS LTD
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Patent Information

Application Number
JP2025272683
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Filing Date
2025-12-22
Publication Date
2026-05-26

AI Technical Summary

Technical Problem

C-reactive protein (CRP) exacerbates tissue damage in various disease conditions by binding to damaged cell membranes and activating the complement system, leading to severe tissue damage and worsening disease outcomes.

Method used

Development of small molecule CRP-binding inhibitors, such as bis(phosphocholine) compounds, that inhibit CRP binding to ligands, forming stable complexes with CRP molecules to prevent complement activation and tissue damage.

Benefits of technology

The inhibitors effectively reduce the severity and duration of tissue damage in conditions like myocardial infarction and stroke by blocking CRP's pathogenic effects, offering a therapeutic approach to mitigate CRP-mediated tissue damage across a range of diseases.

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Abstract

The present invention provides agents and pharmaceutical compositions for use in pharmaceuticals. [Solution] Formula (I): BL-B' (wherein B and B' are independently selected from the bases of formula (BI), where Z is -COOH, -CH2COOH, -PO(OH)(OR 1 ), or -CH2PO(OH)(OR 1 ) is selected from, R 1 The compound comprises H or a phosphate protecting group; W is an alicyclic amine group having 5 to 12 carbon atoms and at least one amine nitrogen atom; W' is H or W' is linked with W to form the alicyclic amine group, Y is selected from -NH-, -N(CH3)-, -CH2-, -NHCO-, -CH2CONH-, -CONH-, CH2NHCO-, or -NHCH2-; L is a linker group. JPEG2026086392000093.jpg29170
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