Tip-loaded microneedle array for percutaneous insertion

The soluble microneedle array design with tip-concentrated active ingredients addresses inefficiencies in conventional systems by enhancing delivery efficiency and reducing waste, facilitating precise and cost-effective drug delivery.

JP2026086578APending Publication Date: 2026-05-26UNIV OF PITTSBURGH OF THE COMMONWEALTH SYST OF HIGHER EDUCATION +1
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
UNIV OF PITTSBURGH OF THE COMMONWEALTH SYST OF HIGHER EDUCATION
Filing Date
2026-02-05
Publication Date
2026-05-26

AI Technical Summary

Technical Problem

Conventional microneedle array-based drug delivery systems face limitations in controlling dosage, efficiency, and waste due to homogeneous distribution of active ingredients, which leads to inefficient drug delivery and increased waste.

Method used

A soluble microneedle array design where active ingredients are concentrated in the microneedles, particularly at the tip, with a base devoid of these ingredients, using fabrication techniques like microcasting and micromilling to create pyramidal or columnar shapes, allowing for precise and efficient delivery.

Benefits of technology

Enhances drug delivery efficiency by reducing waste and increasing the concentration of active ingredients at the needle tips, enabling simultaneous delivery of multiple agents and improving economic feasibility.

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Abstract

To provide a method for forming a microneedle array, which may include the step of forming a microneedle array having one or more types of bioactive components. [Solution] A microneedle array may include a base and a plurality of microneedles extending from the base, and one or more bioactive ingredients may be present in higher concentrations within the microneedles than within the base. The systems and methods disclosed herein include a skin delivery platform based on a soluble microneedle array that can result in efficient, precise, and reproducible delivery of bioactive molecules to human skin. The microneedle array delivery platform can be used to deliver a wide range of bioactive ingredients to patients.
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