Method for separating cells from culture medium in a bioprocess
JP2026090645APending Publication Date: 2026-06-02SARTORIUS STEDIM BIOTECH GMBH
Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- SARTORIUS STEDIM BIOTECH GMBH
- Filing Date
- 2026-03-10
- Publication Date
- 2026-06-02
AI Technical Summary
Technical Problem
Conventional cell separation methods in biopharmaceutical processes face challenges such as rapid filter clogging and inefficiencies in cross-flow filtration due to high cell concentration and viscosity, leading to reduced protein yield and increased economic costs.
Method used
A novel apparatus and method using a hollow fiber module with separate backwash and recirculation lines, controlled by valves and pumps, allowing for simultaneous membrane cleaning and culture medium dilution, optimizing protein yield and process efficiency.
Benefits of technology
Enhances protein yield and maintains filtration performance by integrating membrane washing and dilution, reducing economic and operational constraints in biopharmaceutical processes.
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Smart Images
Figure 2026090645000001_ABST
Abstract
This invention provides a method for separating cells from a culture medium in bioprocesses, particularly biopharmaceutical processes. [Solution] A method for separating cells from a culture medium, comprising: a culture step of culturing cells in a culture medium 14 in a bioreactor; a filtration step of filtering the culture medium 14 in a filtration module 16 having at least one membrane, wherein the culture medium 14 passes through a recirculation circuit; and a rinsing step of rinsing the membrane during filtration with a rinsing solution, wherein the rinsing solution is introduced into the recirculation circuit by rinsing.
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