Method for producing synthetic intermediates of bactericidal pyridine compounds

The described method addresses the challenges of industrial-scale production of bactericidal pyridine compounds by using a reaction in a polar solvent with sodium hydroxide and dimethyl sulfoxide, achieving high-yield production of bactericidal pyridine compounds.

JP2026091134APending Publication Date: 2026-06-03TAMA KAGAKU IND
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
TAMA KAGAKU IND
Filing Date
2024-11-22
Publication Date
2026-06-03

AI Technical Summary

Technical Problem

Existing methods for producing bactericidal pyridine compounds face challenges such as the use of hazardous materials like 3-chloromethylpyridine and potassium t-butoxide, which require careful handling, and are not suitable for industrial-scale production, especially when using pyridines other than 4-substituted pyridines.

Method used

A method involving the reaction of a compound represented by general formula (A) with a compound represented by general formula (1) in a polar solvent containing dimethyl sulfoxide and sodium hydroxide, with controlled water content, to produce a compound represented by general formula (2), followed by reaction with a compound represented by general formula (3) to yield a bactericidal pyridine compound represented by general formula (4).

Benefits of technology

This method enables high-yield production of bactericidal pyridine compounds suitable for industrial applications through a simple and efficient process, minimizing the use of hazardous materials and improving yield.

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Abstract

This invention provides a manufacturing method suitable for industrialization, which allows for the acquisition of synthetic intermediates for bactericidal pyridine compounds in high yield using a simple procedure. [Solution] A method for producing a synthetic intermediate of a bactericidal pyridine compound, comprising the step of reacting a compound represented by general formula (A) and a compound represented by general formula (1) in a polar solvent containing dimethyl sulfoxide in the presence of sodium hydroxide to obtain a compound represented by general formula (2). TIFF2026091134000011.tif57170 (In general formulas (1) and (2), R1 represents an alkylene group having 2 to 8 carbon atoms)
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