Composition containing sugars or sugar alcohols

Abstract

The present invention provides means for delaying the dissolution time of a composition containing sugars or sugar alcohols. [Solution] A composition containing (A) sugars or sugar alcohols, and (B) starch hydrolysate, wherein the solid content is 70% by mass or more, and the dextrose equivalent (DE) of the (B) starch hydrolysate is less than 6.

Description

Technical Field

[0001] The present invention relates to a composition containing saccharides or sugar alcohols.

Background Art

[0002] Oral compositions containing saccharides or sugar alcohols such as candies and caramels are advantageous in that they have a good taste quality and can be retained in the mouth for a long time, and can locally release an active ingredient slowly and act. Utilizing this property, products such as throat lozenges have been developed.

[0003] Patent Document 1 describes a supplement candy formed by dispersing powder A formed of a hydrogen generating material and a water retaining material into food powder B, wherein the powder B contains dextrin or reduced maltose.

[0004] Patent Document 2 describes a fructose candy containing 20 to 80% by weight of fructose and 80 to 20% by weight of branched dextrin, and it is described that branched dextrin having a dextrose equivalent (DE) of 6 to 10 is preferable.

[0005] Patent Document 3 describes a candy containing cyclodextrin (maltosyl cyclodextrin). <0000​​​​​​​​​​​​​​​​​​​​​​​​​​​

[0007] However, in compositions containing sugars or sugar alcohols, the sugars or sugar alcohols dissolve relatively quickly, making it difficult to sustainably release the active ingredient for a sufficiently long period of time.

[0008] Therefore, the object of the present invention is to provide a means for delaying the dissolution time of a composition containing sugars or sugar alcohols. [Means for solving the problem]

[0009] As a result of diligent research, the inventors discovered that starch hydrolysates with a dextrose equivalent (DE) of less than 6 delay the dissolution of sugars or sugar alcohols in the composition, thus completing the present invention.

[0010] Embodiments of the present invention include, but are not limited to, the following. [1] A composition containing (A) sugars or sugar alcohols, and (B) starch hydrolysates, wherein the solid content is 70% by mass or more, and the dextrose equivalent (DE) of the (B) starch hydrolysates is less than 6. [2] The composition according to [1], wherein the DE of the starch hydrolysate (B) is 4 or less. [3] The composition according to [1] or [2], wherein the content of the (B) starch hydrolysate is 0.1 to 90% by mass per solid content. [4] A composition according to any one of [1] to [3], for oral use or for sustained release of the active ingredient. [5] A composition according to any one of [1] to [4], which is a candy or a caramel. [6] (A) sugars or sugar alcohols and (B) starch hydrolysates are to be present together, and The solid content of the composition containing components (A) and (B) above shall be 70% by mass or more. A method for delaying the dissolution of sugars or sugar alcohols, comprising (B) starch hydrolysate having a dextrose equivalent (DE) of less than 6. [7] Coexisting (A) saccharides or sugar alcohols, (B) starch degradation products, and (C) active ingredients, and making the solid content of the composition containing the components (A) to (C) 70% by mass or more A method for improving the sustained release of an active ingredient, which includes that the dextrose equivalent (DE) of the (B) starch degradation product is less than 6. [Advantages of the Invention]

[0011] According to the configuration of the present invention, the dissolution of saccharides or sugar alcohols in the composition can be delayed, and for example, it is suitable for oral use or sustained release of active ingredients. [Modes for Carrying Out the Invention]

[0012] In this specification, an "oral composition" represents a composition that can be orally ingested.

[0013] In this specification, "solid content" represents the part obtained by removing moisture from the oral composition.

[0014] In this specification, "starch degradation product" is also called "malt syrup", "dextrin", "maltodextrin", and represents a product obtained by hydrolyzing starch with an acid, an enzyme, etc., or its reduced product (hydrogenated product), and does not include cyclodextrin.

[0015] In this specification, the dextrose equivalent (DE) indicates the reducing power of the starch degradation product when the reducing power of glucose equal to the amount of the starch degradation product is set to 100, and is an index of the content of reducing sugar in the starch degradation product. In this specification, DE is measured by the Willstätter-Schudel (WS) method. In the case of a reduced starch degradation product, it represents the DE value of the starch degradation product before the reduction treatment.

[0016] [Composition] The composition of the present invention contains (A) saccharides or sugar alcohols and (B) starch degradation products, has a solid content of 70% by mass or more, and is characterized in that the DE of the (B) starch degradation product is less than 6.

[0017] (Component (A): saccharide or sugar alcohol) The composition of the present invention contains, as component (A), at least one compound selected from saccharides and sugar alcohols.

[0018] Saccharides are monosaccharides or disaccharides. Examples of monosaccharides include glucose, fructose, allose, tagatose, sorbose, galactose, allulose, mannose, altrose, talose, idose, or gulose. Examples of disaccharides include sucrose, maltose, lactose, trehalose, or palatinose. Among them, sucrose is preferable from the viewpoint of improving the taste.

[0019] Sugar alcohols are reduction products of monosaccharides or disaccharides, and examples thereof include sorbitol, palatinite (reduced palatinose), xylitol, maltitol, erythritol, lactitol, galactitol, allitol, glucitol, mannitol, altritol, talitol, or iditol. Among them, from the viewpoint of more significantly exhibiting the effects of the present invention, sorbitol, xylitol, maltitol or palatinite is preferable, and sorbitol or palatinite is more preferable in terms of having a low laxative effect and good taste.

[0020] The total content of saccharides or sugar alcohols is, for example, 1 to 99% by mass, 10 to 98% by mass, 20 to 97% by mass, 30 to 95% by mass, or 40 to 95% by mass based on the solid content of the composition of the present invention.

[0021] In one embodiment, the composition of the present invention contains sucrose. The content of sucrose is preferably 25 to 75% by mass, more preferably 40 to 60% by mass per solid content of the composition. In one embodiment, the composition of the present invention contains at least one sugar alcohol selected from the group consisting of sorbitol, xylitol, maltitol and palatinite.

[0022] ((B) component: starch decomposition product) The composition of the present invention comprises at least one starch hydrolysate having a dextrose equivalent (DE) of less than 6 as component (B).

[0023] Starch hydrolysates may be obtained by treating starch with, for example, acid, enzymes (such as α-amylase, β-amylase, glucoamylase, isoamylase, etc.), or both.

[0024] The raw material starch for the starch hydrolysate is not particularly limited and may include starch of plant origin (including algae) found in nature, as well as starch modified by genetic engineering or breeding techniques, or starch that has been physically or chemically modified. Typical sources include cereals, tubers, roots, algae, legumes, and fruits, but cereals, tubers, or roots are preferred. More specifically, one or more selected from corn, peas, potatoes, sweet potatoes, bananas, barley, wheat, rice, sago, amaranth, tapioca, canna, and sorghum can be used. Glutinous or non-glutinous starch can be used as the raw material starch.

[0025] From the viewpoint of more significantly exhibiting the effects of the present invention, the DE of the starch hydrolysate is preferably 5.5 or less, more preferably 5 or less, even more preferably 4.5 or less, and even more preferably 4 or less. From the viewpoint of suppressing excessive viscosity increase during the production of the composition, it is preferably 1 or more, more preferably 2 or more, and even more preferably 3 or more.

[0026] Starch hydrolysates can be produced by known methods. Alternatively, commercially available starch hydrolysates may be used. Preferred specific examples of starch hydrolysates include, for example, PineDex (PDx) #100 or PineDex #300 manufactured by Matsutani Chemical Industry Co., Ltd.

[0027] (B) The total content of starch hydrolysates (less than DE6) is, for example, 0.1% by mass or more, 0.2% by mass or more, 0.5% by mass or more, or 1% by mass or more, relative to the solid content of the oral composition, and from the viewpoint of more significantly exhibiting the effects of the present invention, it is preferably 2% by mass or more, more preferably 5% by mass or more, even more preferably 10% by mass or more, even more preferably 15% by mass or more, particularly preferably 20% by mass or more, and particularly more preferably 25% by mass or more. Furthermore, the total content of (B) starch hydrolysates (less than DE6) can be, for example, 90% by mass or less, 80% by mass or less, or 70% by mass or less, relative to the solid content of the oral composition, and from the viewpoint of suppressing viscosity increase during the production of the composition, it can be preferably 60% by mass or less, more preferably 50% by mass or less, even more preferably 40% by mass or less, and even more preferably 30% by mass or less.

[0028] When a starch hydrolysate with a DE of 6-40 is used instead of component (B), the effect of delaying the dissolution of sugars or sugar alcohols in component (A) decreases, but the effect of delaying the dissolution of component (A) is significantly greater than when no starch hydrolysate is included. Therefore, depending on the application of the oral composition, a starch hydrolysate with a DE of 6-50 can be used in combination with component (A).

[0029] ((C) Ingredients: Active ingredients) The composition of the present invention may further contain an active ingredient as an optional component.

[0030] The active ingredient may be appropriately determined depending on the form and use of the composition, but examples include ingredients involved in the function of foods (including foods with functional claims, foods with nutritional function claims, foods for special dietary uses, etc.), animal feed, pharmaceuticals, quasi-drugs, veterinary pharmaceuticals, veterinary quasi-drugs, agricultural products (including pesticides, fertilizers, vitality enhancers, etc.), cosmetics, and daily necessities (including fragrances, detergents, etc.). The active ingredient may be, for example, an active ingredient in food, animal feed, pharmaceuticals, quasi-drugs, veterinary pharmaceuticals, veterinary quasi-drugs, agricultural products, or cosmetics that exhibits physiological activity.

[0031] In one embodiment, the active ingredient is an active ingredient for the mouth or throat.

[0032] In this specification, "active ingredient for the mouth or throat" is not particularly limited to any ingredient that provides a physiologically favorable effect on the mouth or throat and can be taken orally, and includes pharmaceutical active ingredients and other ingredients (e.g., food ingredients).

[0033] Examples of active ingredients for the mouth or throat include those that have effects such as sterilization or antibacterial action, cough suppression, expectorant action, moisturizing, anti-inflammatory action, caries prevention, periodontal disease prevention, saliva secretion promotion, and skin regeneration promotion. Specific examples of active ingredients for the mouth or throat include, for example, at least one selected from the group consisting of aromatic oils (peppermint oil, spearmint oil, eucalyptus oil, clove oil, etc.), acidulants (citric acid, lactic acid, malic acid, acetic acid, tartaric acid, adipic acid, etc.), herbal medicines (licorice, quince, balloon flower, chamomile, etc.), antibacterial agents (cetylpyridinium chloride hydrate (CPC), etc.), anti-inflammatory agents (dipotassium glycyrrhizinate, tranexamic acid, etc.), vitamins (ascorbic acid or its salts, etc.), propolis, and manuka honey.

[0034] (Other ingredients) The oral composition of the present invention may contain, as other components in addition to components (A) to (C), at least one selected from the group consisting of starch hydrolysates other than component (B), starch [raw starch, modified starch (e.g., acetylated starch, acetylated phosphate cross-linked starch, acetylated adipic acid cross-linked starch, sodium octenyl succinate starch, starch acetate, phosphate monoesterified phosphate cross-linked starch, phosphorylated starch, phosphate cross-linked starch, sodium starch glycolate, sodium starch phosphate esterification, pregelatinized starch, enzyme-treated starch, starch that has undergone physical treatment such as moist heat or dry heat treatment, etc.)], oligosaccharides, dietary fiber, oils and fats, salt, water, fruit juice, coffee products, tea products, chocolate, cocoa products, foaming agents, thickeners (polysaccharides, etc.), emulsifiers, antioxidants, preservatives, sweeteners, seasonings, spices, flavors, colorants, pH adjusters, excipients, preservatives, and fungicides.

[0035] (component content ratio) The content of component (B) relative to 1 part by mass of component (A) in the composition of the present invention is, for example, 0.01 to 100 parts by mass, preferably 0.02 to 50 parts by mass, more preferably 0.05 to 20 parts by mass, and can be, for example, 0.1 to 10 parts by mass, 0.1 to 5 parts by mass, 0.1 to 2 parts by mass, 0.1 to 1 part by mass, or 0.1 to 0.5 parts by mass.

[0036] (Form of composition) The composition of the present invention is solid, and its shape and size are not particularly limited. Examples of the composition of the present invention include food (candies (hard candies, soft candies, etc.), caramels, tablets, etc.), animal feed, pharmaceuticals, quasi-drugs (lozenges, tablets, candies, etc.), agricultural products (including pesticides, fertilizers, plant stimulants, etc.), quasi-drugs, veterinary pharmaceuticals, veterinary quasi-drugs, cosmetics, daily cosmetic products, agricultural products, or daily products. Among these, candies or caramels are preferred as the composition of the present invention, candies are more preferred, and hard candies are even more preferred.

[0037] The solid content of the composition of the present invention is, for example, 70% by mass or more of the total amount of the composition, and from the viewpoint of more significantly exhibiting the effects of the present invention, it is preferably 80% by mass or more, more preferably 85% by mass or more, even more preferably 90% by mass or more, even more preferably 92% by mass or more, particularly preferably 95% by mass or more, and particularly more preferably 97% by mass or more.

[0038] The oral composition of the present invention is preferably prepared by a manufacturing method comprising preparing a composition containing component (A) and component (B), and heating and dissolving component (A) and component (B) of the composition.

[0039] (Effects and Uses) The composition of the present invention suppresses the dissolution of sugars or sugar alcohols, so it takes a long time to dissolve even in the presence of water. For example, when taken orally, it can be licked and dissolved in the mouth for a long time. Therefore, when component (C) is included in the composition of the present invention, the composition of the present invention slowly releases component (C) in the presence of water, allowing the active ingredient to act locally for a long time. For example, when the composition of the present invention is taken orally, component (C) is slowly released into the mouth, allowing the active ingredient to act in the mouth and throat for a long time.

[0040] In one embodiment, when the composition of the present invention is immersed in water (20°C, 40g) for 1 hour, W2 is the mass of the composition after immersion and W1 is the mass of the composition before immersion. In this embodiment, W2 / W1 is 40% (=0.40) or more, or 45% or more, for example, 100% or less, 90% or less, 80% or less, 70% or less, 60% or less, or 50% or less. The shape of the composition to be immersed is preferably a hemispherical (dome-shaped) with a diameter of 2.4 cm.

[0041] [Method for delaying the dissolution of sugars or sugar alcohols, method for improving the sustained release of active ingredients] The present invention provides a method for delaying the dissolution of sugars or sugar alcohols, comprising (A) coexisting with sugars or sugar alcohols and (B) starch hydrolysates, and The solid content of the composition containing components (A) and (B) above shall be 70% by mass or more. It contains the above (B) starch hydrolysate and is characterized in that the DE is less than 6.

[0042] The present invention provides a method for improving the sustained release of the active ingredient, which involves coexisting (A) sugars or sugar alcohols, (B) starch hydrolysates, and (C) the active ingredient, and The solid content of the composition containing the above components (A) to (C) shall be 70% by mass or more. It contains the above (B) starch hydrolysate and is characterized in that the DE is less than 6.

[0043] Specific examples of components (A) to (C) of these methods, other components, and their content are those described in the [Composition] section.

[0044] The present invention will be described in detail and specifically below with reference to examples, but the present invention is not limited to these examples. In the following examples, unless otherwise specified, "parts" refers to parts by mass, and "%" refers to mass percent. Also, unless otherwise specified, the amounts in the tables refer to parts by mass. [Examples]

[0045] [Test Example 1: Starch Hydrolysate Blending Test in Candy 1] The candy was prototyped and evaluated using the following procedure. (1) The powdered raw materials according to the formulation in Table 1 were placed in a pot and mixed with water until the solid content concentration reached 60%. (2) The mixture was further heated and stirred until it was boiled down to a solid content of 99%. (3) The resulting mixture was poured into a silicone mold and left to solidify at room temperature overnight to prepare hemispherical (dome-shaped) candies with a diameter of 2.4 cm. (4) The resulting candy was placed in a container and immersed in water (20°C, 40g) for 1 hour, after which the water was removed. (5) The appearance of the candy was evaluated and its weight was measured. The weight before immersion in water was taken as W1, and the weight after immersion was taken as W2. The post-immersion weight (W2 / W1), standardized by the weight before immersion, was calculated. A larger W2 / W1 indicates that the dissolution of the candy was delayed.

[0046] The results are shown in Table 1. Adding starch hydrolysates delayed the dissolution of the candy. The smaller the DE, the greater the dissolution delay effect. In particular, when dextrin with DE 4 was used, the weight loss due to immersion was significantly reduced even at half the dose, showing an unexpectedly significant dissolution delay effect (Example 1). Furthermore, no difference in effect was observed between starch hydrolysates and their reduced products when the DE was the same (Reference Examples 2 and 3).

[0047] [Table 1]

[0048] [Test Example 2: Starch Hydrolysate Blending Test in Candy 2] Candy was prepared using the formulations shown in Table 2 in the same manner as in Test Example 1, and the W2 / W1 ratio was measured. Even for candies containing maltitol or palatinite, the addition of dextrin increased the W2 / W1 ratio, demonstrating a significant effect in delaying dissolution.

[0049] [Table 2]

Claims

1. A composition containing (A) sugars or sugar alcohols, and (B) starch hydrolysates, wherein the solid content is 70% by mass or more, and the dextrose equivalent (DE) of the (B) starch hydrolysates is less than 6.

2. The composition according to claim 1, wherein the DE of the starch hydrolysate (B) is 4 or less.

3. The composition according to claim 1 or 2, wherein the content of the starch hydrolysate (B) is 0.1 to 90% by mass based on the solid content.

4. The composition according to claim 1 or 2, for oral use or for sustained release of the active ingredient.

5. The composition according to claim 1 or 2, wherein it is a type of candy or caramel.

6. (A) sugars or sugar alcohols and (B) starch hydrolysates are to be present together, and The solid content of the composition containing components (A) and (B) above shall be 70% by mass or more. A method for delaying the dissolution of sugars or sugar alcohols, comprising (B) starch hydrolysate having a dextrose equivalent (DE) of less than 6.

7. (A) sugars or sugar alcohols, (B) starch hydrolysates, and (C) active ingredients must be present together, The solid content of the composition containing the above components (A) to (C) shall be 70% by mass or more. A method for improving the sustained release of an active ingredient, wherein the dextrose equivalent (DE) of the starch hydrolysate (B) is less than 6.

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