Method for producing deuterium compounds

The use of 2-propanol, hexafluoro-2-propanol, and an iridium catalyst in the deuteration of aromatic compounds efficiently produces deuterium compounds by generating hydrogen or deuterium gas in situ, addressing inefficiencies in conventional methods.

JP2026109371AActive Publication Date: 2026-07-01NIPPON SANSO CORP +1
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Patent Information

Application Number
JP2024224443
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Filing Date
2024-12-19
Publication Date
2026-07-01
Estimated Expiration
2044-12-19

AI Technical Summary

Technical Problem

Conventional methods for producing deuterium compounds, particularly those containing aromatic rings, require long reaction times and batch processes, leading to inefficient production.

Method used

A method involving the use of a solvent system comprising 2-propanol and hexafluoro-2-propanol, with an iridium catalyst, and a deuterium source like heavy water, which generates hydrogen or deuterium gas in situ to promote efficient deuteration without external gas introduction or catalyst activation steps.

Benefits of technology

This approach allows for the efficient production of deuterium compounds with high deuteration rates and yields, reducing reaction time and eliminating the need for external gas introduction and catalyst activation.

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Abstract

This invention provides a method for producing deuterium compounds that can be obtained efficiently. [Solution] A method for producing a deuterium compound includes a deuteration step of contacting a compound having at least one of an aromatic ring and a heterocycle with a deuterium source in the presence of a solvent and a catalyst, wherein the solvent includes at least one of 2-propanol and hexafluoro-2-propanol, the catalyst includes iridium, and the deuterium source includes at least one of heavy water and a deuteration solvent.
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Citation Information

Patent Citations

  • Safe, environment-friendly and cheap method and device for producing deuterated aromatic ring compound

    CN111099955A

  • Deuteration method of aromatic compounds

    JP2014111561A

  • Deuterated compound production method

    JP2023079215A

  • A polypeptide product

    KR1020220046444A

  • Method of deuteration using mixed catalyst

    WO2005070853A1