Disinfectant composition

Abstract

The present invention provides a disinfectant composition that is excellent in suppressing skin irritation and has a good effect in inactivating non-enveloped viruses, an article impregnated with the disinfectant composition, a method for inactivating non-enveloped viruses, and a method for producing the disinfectant composition. [Solution] A disinfectant composition containing (A) 40% to 95% by mass of ethanol, (B) 0.20% to 3.0% by mass of one or more selected from gluconic acid and its alkali metal salts, and (C) 0.10% to 2.0% by mass of a water-soluble polyhydric alcohol, with a pH of 5.0 or less at 25°C.

Description

Technical Field

[0001] The present invention relates to a disinfectant composition, a disinfectant composition-impregnated article, a method for inactivating non-enveloped viruses, and a method for producing a disinfectant composition.

Background Art

[0002] Viral acute gastroenteritis and diarrhea have been confirmed not only as outbreaks in nursing homes, hospitals, schools, etc., but also as outbreaks due to food poisoning through contaminated food in cooking facilities, restaurants, etc. are frequently reported. As causative viruses of food poisoning, viruses without envelopes such as norovirus, sapovirus, rotavirus, etc. are known, and these viruses can cause severe symptoms when infecting children and the elderly.

[0003] In particular, norovirus is regarded as a problem virus that causes outbreaks. The route of infection is well known to be oral infection by eating shellfish such as raw oysters, but in homes and public facilities, etc., secondary infections from the virus present on the fingers of people who have touched contaminated food, cooking utensils, in the vomit or feces of patients, or in the surrounding environment of patients are also frequently reported. In particular, such secondary infections lead to outbreaks and spread of infection, and are a major cause of the increase in the number of patients.

[0004] Non-enveloped viruses such as norovirus are covered with a strong capsid protein, and are difficult to inactivate compared to enveloped viruses, and simple alcohol alone cannot sufficiently inactivate them. As a method for inactivating viruses, alcohol preparations mainly composed of ethanol are generally known, but a method using a disinfectant composition mainly composed of ethanol and adjusted to an acidic pH as a more effective disinfectant is known. (a) Ethanol or isopropyl alcohol 40 to 90 A disinfectant is disclosed that contains (b) 0.1-2% lactic acid, (c) 0.01-2% citric acid, and (d) 0.001-0.1% zinc-containing compound that releases zinc ions, and has a pH of 2.5-5.0. Patent Document 2 discloses a virus inactivator characterized by comprising ethanol and an acid selected from the group consisting of tartaric acid, pyrophosphate, polyphosphate, and phytic acid, having a pH of 1.0 to 6.0, and not containing antimicrobial fine particles. Patent Document 3 discloses a virus inactivator characterized by comprising ethanol and two acid agents selected from the group consisting of citric acid, tartaric acid, and phosphoric acid, and having a pH of 1.0 to 6.0.

[0005] Furthermore, in the virus inactivation tests described in these patent documents, feline calicivirus, a non-enveloped virus, is used as a surrogate virus for norovirus. The United States Environmental Protection Agency (EPA) norovirus testing method commonly uses feline calicivirus strain F9 as a surrogate virus, and currently, feline calicivirus is primarily used as a surrogate virus for norovirus in antiviral tests and experiments both in Japan and internationally. [Prior art documents] [Patent Documents]

[0006] [Patent Document 1] Japanese Patent Publication No. 2008-255101 [Patent Document 2] Japanese Patent Publication No. 2018-080126 [Patent Document 3] Japanese Patent Publication No. 2018-199635 [Overview of the project] [Problems that the invention aims to solve]

[0007] It is generally known that the higher the ethanol concentration, the greater the virus inactivation effect. Furthermore, it is known that the more acidic the pH of an ethanol-based disinfectant is made with organic acids, the more effective it is at inactivating feline calicivirus. On the other hand, ethanol can cause skin irritation due to its dehydrating and protein denaturing effects. However, healthy skin has a slightly acidic pH of 4.5 to 6.0, so there is a problem in that the more acidic the ethanol is made, the more it can cause skin irritation. Patent documents 1 to 3 describe compositions that have an inactivating effect on feline calicivirus, but all of them tend to cause skin irritation, and the aforementioned problem has not been solved.

[0008] This invention was made in view of the above problems, and provides a disinfectant composition, an article impregnated with the disinfectant composition, a method for inactivating non-enveloped viruses, and a method for producing the disinfectant composition, which have excellent effects in suppressing skin irritation and good effects in inactivating non-enveloped viruses. [Means for solving the problem]

[0009] The present invention relates to a disinfectant composition containing (A) 40% to 95% by mass of ethanol, (B) 0.20% to 3.0% by mass of one or more selected from gluconic acid and its alkali metal salts, and (C) 0.10% to 2.0% by mass of a water-soluble polyhydric alcohol, with a pH of 5.0 or less at 25°C.

[0010] Furthermore, the present invention relates to a disinfectant composition-impregnated article in which the above-mentioned disinfectant composition is impregnated into a substrate.

[0011] Furthermore, the present invention relates to a method for inactivating non-enveloped viruses, which involves bringing the above-mentioned disinfectant composition into contact with a target surface where non-enveloped viruses are present.

[0012] Furthermore, the present invention involves mixing (A) ethanol [hereinafter referred to as component (A)], (B) one or more selected from gluconic acid and its alkali metal salts [hereinafter referred to as component (B)], and (C) a water-soluble polyhydric alcohol [hereinafter referred to as component (C)]. The present invention relates to a method for producing a disinfectant composition containing (A) 40% to 95% by mass, (B) 0.20% to 3.0% by mass, and (C) 0.10% to 2.0% by mass, with a pH of 5.0 or less at 25°C. [Effects of the Invention]

[0013] The present invention provides a disinfectant composition that is excellent in suppressing skin irritation and has a good effect in inactivating non-enveloped viruses, an article impregnated with the disinfectant composition, a method for inactivating non-enveloped viruses, and a method for producing the disinfectant composition. [Modes for carrying out the invention]

[0014] The present inventors investigated various components to solve the above problems and found that by adding 0.20% to 3.0% by mass of one or more selected from gluconic acid and its alkali metal salts (component B) and 0.10% to 2.0% by mass of a water-soluble polyhydric alcohol (component C) to a hand sanitizer mainly composed of ethanol (component A), a sufficient hand-skin irritation suppression effect is achieved even at low pH, and an inactivation effect against non-enveloped viruses is also achieved, thus completing the present invention. It is not predictable to those skilled in the art that a composition containing 0.20% to 3.0% by mass of one or more selected from gluconic acid and its alkali metal salts and 0.10% to 2.0% by mass of a water-soluble polyhydric alcohol can suppress hand irritation even at low pH. In this invention, disinfection includes one or more selected from virus inactivation, antiviral, antiviral, sterilization of bacteria and fungi, and antibacterial. Therefore, the disinfectant composition of the present invention may be one or more compositions selected from a virus inactivator composition, a virus removing agent composition, an antiviral agent composition, a bactericide composition, a disinfectant composition, and an antibacterial agent composition.

[0015] <Disinfectant composition> The disinfectant composition of the present invention contains (A) ethanol [hereinafter referred to as component (A)], one or more selected from gluconic acid and its alkali metal salts [hereinafter referred to as component (B)], and (C) a water-soluble polyhydric alcohol [hereinafter referred to as component (C)], and has a pH of 5.0 or less at 25°C. The disinfectant composition of the present invention may be a disinfectant composition in which component (A), component (B), and component (C) are blended.

[0016] As the raw material ethanol of component (A), ordinary ones such as fermentation ethanol, synthetic ethanol, bioethanol, and purified ethanol can be used, but it is preferable to adopt those with a quality that can ensure safety according to the disinfection use.

[0017] Examples of the gluconic acid and its alkali metal salts of component (B) include gluconic acid, sodium gluconate, potassium gluconate, etc. These may be used alone or in combination of two or more.

[0018] The water-soluble polyhydric alcohol of component (C) includes preferably water-soluble polyhydric alcohols having a molecular weight of 250 or less such as glycerin, diglycerin, ethylene glycol, propylene glycol, 1,3-propanediol, butylene glycol, erythritol, sorbitol, etc., and polyethylene glycol having a weight average molecular weight of 3000 or more and 10000 or less. One or more of these can be used. Among these, component (C) is preferably one or more selected from glycerin and polyethylene glycol, and it is more preferable to use glycerin and polyethylene glycol in combination. Polyethylene glycol can also be used as a feel adjuster, and suitable ductility can be obtained when applied to fingers or skin. The water solubility of the present invention refers to a substance having a solubility of 10 g / 100 g water or more at 20°C.

[0019] <Composition and Other Components> From the viewpoint of obtaining sufficient disinfection effects such as virus inactivation and / or sterilization, the disinfectant composition of the present invention contains component (A) at 40% by mass or more, preferably 45% by mass or more, more preferably 55% by mass or more in the disinfectant composition, and from the viewpoints of solubility and storage stability of the compounding components, 95% by mass or less, preferably 90% by mass or less, more preferably 75% by mass or less.

[0020] From the viewpoints of obtaining a sufficient inactivation effect on non-enveloped viruses and a hand roughness suppressing effect, the disinfectant composition of the present invention contains component (B) at 0.20% by mass or more, preferably 0.30% by mass or more, more preferably 0.40% by mass or more, still more preferably 0.60% by mass or more, even more preferably 0.80% by mass or more in the disinfectant composition, and from the viewpoints of solubility and storage stability of the compounding components, 3.0% by mass or less, preferably 2.5% by mass or less, more preferably 2.0% by mass or less. In the present invention, the regulation regarding the mass of component (B) shall use the value converted to the acid form.

[0021] From the viewpoint of obtaining a hand roughness suppressing effect, the disinfectant composition of the present invention contains component (C) at 0.10% by mass or more, preferably 0.20% by mass or more, more preferably 0.30% by mass or more in the disinfectant composition, and from the viewpoint of not leaving a sticky feeling after drying, 2.0% by mass or less, preferably 1.5% by mass or less, more preferably 1.0% by mass or less, still more preferably 0.8% by mass or less, even more preferably 0.6% by mass or less.

[0022] In the disinfectant composition of the present invention, the mass ratio (B) / (C) of the content of component (B) to the content of component (C) is preferably 0.5 or more, more preferably 0.6 or more, even more preferably 0.7 or more, even more preferably 0.8 or more, even more preferably 1.0 or more, even more preferably 1.5 or more, even more preferably 2.0 or more, even more preferably 2.5 or more, and preferably 10 or less, more preferably 8.0 or less, even more preferably 6.0 or less, even more preferably 5.0 or less, and even more preferably 4.5 or less.

[0023] The disinfectant composition of the present invention may optionally contain (D) an acid (excluding component (B), hereinafter referred to as component (D)), as long as it does not impair the effect of suppressing skin irritation. In the disinfectant composition of the present invention, it is preferable to use component (D) together with component (B) as a pH adjuster, from the viewpoint of virus inactivation effect and bactericidal effect. (D) Examples of components include hydrochloric acid, sulfuric acid, phosphoric acid, and organic acids with a molecular weight of 250 or less, such as citric acid, succinic acid, malic acid, fumaric acid, adipic acid, tartaric acid, and lactic acid, with one or more selected from hydrochloric acid, sulfuric acid, phosphoric acid, and citric acid being preferred.

[0024] If the disinfectant composition of the present invention contains component (D), component (D) is preferably contained in the disinfectant composition in an amount of 0.01% by mass or more, more preferably 0.02% by mass or more, even more preferably 0.03% by mass or more, even more preferably 0.04% by mass or more, and preferably 2.0% by mass or less, more preferably 1.5% by mass or less, even more preferably 1.0% by mass or even more preferably 0.5% by mass or less, from the viewpoint of inactivating non-enveloped viruses and suppressing skin roughness. When the disinfectant composition of the present invention contains phosphoric acid as component (D), from the viewpoint of inactivating non-enveloped viruses, the total content of component (B) and phosphoric acid is preferably 1.2% by mass or more and 1.5% by mass or less in the disinfectant composition.

[0025] When the disinfectant composition of the present invention contains phosphoric acid or an organic acid as component (D), the mass ratio (B) / (D) of the content of component (B) to the content of component (D) in the disinfectant composition of the present invention is 0.2 or more, more preferably 0.5 or more, even more preferably 1.0 or more, even more preferably 1.5 or more, and preferably 30 or less, more preferably 20 or less, even more preferably 10 or less, and even more preferably 7 or less, when converted to the acid type, from the viewpoint of inactivating non-enveloped viruses and suppressing skin roughness.

[0026] The disinfectant composition of the present invention preferably contains (E) a skin protectant [hereinafter referred to as (E) component] to an extent that does not impair the virus inactivation effect, bactericidal effect, or solution stability. (E) Examples of component include one or more selected from glycyrrhetinic acid, nicotinamide, ceramide, pseudoceramide, allantoin, hyaluronic acid, urea, tocopherol acetate, and dipotassium glycyrrhizinate, with glycyrrhetinic acid being preferred.

[0027] If the disinfectant composition of the present invention contains component (E), component (E) is preferably contained in the disinfectant composition in an amount of 0.01% by mass or more, more preferably 0.015% by mass or more, preferably 0.2% by mass or less, and more preferably 0.1% by mass or less.

[0028] The disinfectant composition of the present invention may optionally contain pH adjusters other than the acidic agents (components (B) and (D)), as long as they do not impair the virus inactivation effect and bactericidal effect. The pH adjuster is not particularly limited, as long as it is suitable for topical skin preparations such as pharmaceuticals and cosmetics when applied to the body surface. Examples of such pH adjusters include hydroxides of alkali metals such as sodium hydroxide and potassium hydroxide; alkanolamines such as monoethanolamine, diethanolamine, and triethanolamine; alkylamines such as 2-amino-2-methyl-1-propanol and 2-amino-2-methyl-1,3-propanediol; basic amino acids such as lysine and arginine, etc. One or more of these can be used.

[0029] The disinfectant composition of the present invention can optionally contain a virus inactivator as long as the effects of the present invention are not impaired. By containing a virus inactivator in the disinfectant composition of the present invention, the virus inactivating effect of the disinfectant composition is further improved. Examples of virus inactivators include, for example, green tea extract, acai berry extract, grape extract, evening primrose seed extract, oolong tea extract, and bilberry extract. One or more of these can be used.

[0030] The disinfectant composition of the present invention can optionally contain a solvent, a surfactant, a metal corrosion inhibitor, a chelating agent, a buffer, a bactericide such as polylysine, an antioxidant, a preservative, a fragrance, and a pigment (however, excluding those corresponding to components (A) to (E), the pH adjuster, and the virus inactivator).

[0031] From the viewpoint of obtaining a bactericidal effect and a sufficient inactivating effect on non-enveloped viruses, the pH at 25°C of the disinfectant composition of the present invention is preferably 5.0 or less, more preferably 4.5 or less, still more preferably 4.0 or less, even more preferably 3.5 or less, and from the viewpoint of preventing hand roughness, it is preferably 1.0 or more, more preferably 2.0 or more, still more preferably 2.5 or more, even more preferably 3.0 or more. The pH of the disinfectant composition of the present invention is measured in accordance with JIS Z-8802:2011 "Method for Measuring pH", and specifically, it is measured in accordance with the following measurement method.

[0032] <Method for Measuring pH> A pH measuring composite electrode (glass ground-joint sleeve type, manufactured by Horiba, Ltd.) with saturated potassium chloride aqueous solution (3.33 mol / L) as the internal solution of the pH electrode is connected to a pH meter (pH / ion meter F-71, manufactured by Horiba, Ltd.). Next, calibration is performed using pH 4.01 standard solution (phthalate standard solution), pH 6.86 (neutral phosphate standard solution), and pH 9.18 standard solution (borate standard solution). The disinfectant composition to be measured is placed in a sample bottle and immersed in a 25°C constant temperature bath for 30 minutes beforehand. The electrode of the pH meter is immersed in the sample that has been adjusted to a constant temperature, and the pH is measured after 1 minute.

[0033] The disinfectant composition of the present invention contains water from the viewpoint of the solubility of the constituent components. The water is not particularly limited, but examples include tap water, well water, deionized water, and distilled water. It is preferable that the amount of water used is the remainder of the composition (an amount that totals 100% by mass). The disinfectant composition of the present invention may contain water in amounts of, for example, 4% by mass or more, further 10% by mass or more, further 16% by mass or more, further 20% by mass or more, and 59% by mass or less, further 54% by mass or less, and further 49% by mass or less.

[0034] The objects to be disinfected by the disinfectant composition of the present invention are not particularly limited, but include: (1) the body, such as human skin and fingers; (2) hard surfaces, such as cooking utensils, countertops, display cases, refrigerators, tables, desks, chairs, doorknobs, toilets (toilet bowls and seats), water faucets, tableware, food processing equipment, walls, floors, etc; and (3) food, such as the surface of food materials like vegetables. The disinfectant composition of the present invention can be used particularly suitably for disinfecting body surfaces such as hands.

[0035] The disinfectant composition of the present invention can be used in the same way as known alcohol-based disinfectants. For example, the disinfectant composition of the present invention can be sprayed onto the surface to be disinfected using a sprayer or the like, and then rubbed in with the fingers or wiped with a nonwoven fabric or the like, or the surface to be disinfected can be wiped with a nonwoven fabric or the like impregnated with the disinfectant composition.

[0036] The disinfectant composition of the present invention can be suitably used not only for sterilizing target surfaces, but also for inactivating, deviralizing, and antiviral non-enveloped viruses.

[0037] The disinfectant composition of the present invention has a good effect in inactivating non-enveloped viruses. Non-enveloped viruses may include, for example, single-stranded (+) RNA viruses, single-stranded (-) RNA viruses, double-stranded RNA viruses, single-stranded DNA viruses, and double-stranded DNA viruses that do not have a lipid layer or lipid bilayer on their surface. Examples of non-enveloped viruses include, for example, adenoviruses, parvoviruses, papovaviruses, and human papillomaviruses, which have DNA genomes, and rotaviruses, coxsackieviruses, enteroviruses, sapoviruses, noroviruses, polioviruses, echoviruses, hepatitis A virus, hepatitis E virus, rhinoviruses, astroviruses, and bacteriophage MS2, which have RNA genomes.

[0038] <Method for inactivating non-enveloped viruses> The present invention provides a method for inactivating non-enveloped viruses by bringing the disinfectant composition of the present invention into contact with a target surface, particularly a target surface where non-enveloped viruses are present. The method for inactivating non-enveloped viruses of the present invention may be a method for inactivating non-enveloped viruses by bringing the disinfectant composition of the present invention into contact with a target surface where non-enveloped viruses are present. In the non-enveloped virus inactivation method of the present invention, the disinfectant composition of the present invention can be brought into contact with the target surface without dilution. The disinfectant composition used in the non-enveloped virus inactivation method of the present invention can be appropriately adapted to the embodiments described in the description of the disinfectant composition of the present invention.

[0039] The non-enveloped virus inactivation method of the present invention may be a method of inactivating non-enveloped viruses by bringing the disinfectant composition of the present invention into contact with the hands, particularly the hands on which the virus is present.

[0040] The target surfaces for the non-enveloped virus inactivation method of the present invention are not particularly limited, but include: (1) the body, such as human skin and fingers; (2) hard surfaces, such as cooking utensils, countertops, display cases, refrigerators, tables, desks, chairs, doorknobs, toilets (toilet bowls and seats), water faucets, tableware, food processing equipment, walls, floors, etc; and (3) food, such as the surface of food materials like vegetables. The target surface for the non-enveloped virus inactivation method of the present invention is preferably a body surface such as the fingers.

[0041] Methods for bringing the disinfectant composition of the present invention into contact with a target surface where non-enveloped viruses are present include spraying or applying the disinfectant composition of the present invention to a target surface where non-enveloped viruses are present or suspected to be present, or immersing a target article in the disinfectant composition of the present invention. Alternatively, the disinfectant composition of the present invention may be impregnated into a substrate such as a nonwoven fabric, and the substrate impregnated with the disinfectant composition of the present invention may be brought into contact with the target surface.

[0042] When spraying or applying the disinfectant composition of the present invention to a target surface, the disinfectant composition of the present invention may be filled into a container equipped with a sprayer and sprayed in the form of droplets or foam, or the disinfectant composition of the present invention may be poured from the container onto the target surface and rubbed in with fingers or applied with a brush or the like. Examples of containers equipped with a sprayer include trigger-type spray containers, pump-type spray containers and other manual spraying devices that do not use propellants, and aerosols that use propellants. The container equipped with the sprayer is preferably a trigger-type spray capable of spraying the contents in droplet or foam form, and more preferably a trigger-type spray equipped with a mechanism for spraying the contents in droplet form or a mechanism for forming foam (foam-forming mechanism).

[0043] When the disinfectant composition of the present invention is impregnated into a nonwoven fabric and brought into contact with a target surface, the nonwoven fabric can be processed into a sheet, and it is preferable that the fibers constituting the nonwoven fabric consist of one or more fibers selected from hydrophilic fibers and hydrophobic fibers. In this invention, hydrophilic fibers refer to fibers with a moisture content (at 20°C, 65%RH) exceeding 5% by mass under standard conditions. The moisture content under standard conditions is measured by the methods specified in JIS L 1013 and JIS L 1015. Hydrophobic fibers refer to fibers with a moisture content (at 20°C, 65%RH) of 5% by mass or less under standard conditions. The method of impregnating a nonwoven fabric with the disinfectant composition of the present invention and bringing it into contact with a target surface involves pressing the nonwoven fabric impregnated with the disinfectant composition of the present invention against the target surface and applying external force within a range that does not damage the object, thereby transferring the disinfectant composition impregnated in the nonwoven fabric to the target surface and bringing it into contact with it. This can be done by rubbing or wiping.

[0044] The amount of the disinfectant composition of the present invention used is not particularly limited, but for example, when applied to the hands, from the viewpoint of bactericidal effect, inactivation effect of non-enveloped viruses, and effect of suppressing skin roughness, the disinfectant composition is usually applied to the palms of both hands in a range of preferably 0.1 mL or more, more preferably 0.2 mL or more, preferably 5 mL or less, and more preferably 4 mL or less.

[0045] From the viewpoint of non-enveloped virus inactivation performance, the time for which the disinfectant composition of the present invention is in contact with a target surface containing non-enveloped viruses (the time for which it is left to stand) is preferably 15 seconds or more. After contact, you can let it dry as is, wipe it with a clean cloth, or rinse it with water. When rinsing, you can apply external force (physical force) with a sponge or similar, or simply rinse it with a stream of water.

[0046] <Disinfectant composition impregnated articles> The disinfectant composition of the present invention can also be used as a disinfectant composition-impregnated article by impregnating a substrate with the disinfectant composition of the present invention. A disinfectant composition-impregnated article obtained by impregnating a substrate with the disinfectant composition of the present invention is preferable from the viewpoint of workability in disinfection work. In other words, the present invention provides a disinfectant composition-impregnated article in which the disinfectant composition of the present invention is impregnated into a substrate. The disinfectant composition-impregnated article of the present invention may be an article containing a disinfectant composition for body surfaces such as hands, or an article impregnated with a disinfectant composition for hard surfaces.

[0047] The substrate used in the disinfectant composition-impregnated article of the present invention is flexible, pliable, or pliable, capable of impregnating with the disinfectant composition, possesses sufficient strength during use, and does not generate debris. It is preferable to use a substrate capable of impregnating the amount of disinfectant composition described below under no load.

[0048] Examples of such substrates include fibrous structures composed of fibrous materials, such as various types of paper, nonwoven fabrics, woven fabrics, or knitted fabrics. Examples of fibrous materials that constitute these fibrous structures include cellulose fibers, modified cellulose fibers, synthetic fibers, and mixtures of two or more of these. Furthermore, porous structures obtained by dispersing air bubbles in a resin (for example, sponge-like structures) can also be used as the substrate. These substrates may be substrate sheets.

[0049] In a method for disinfecting a target surface using a disinfectant composition-impregnated article impregnated with the disinfectant composition of the present invention, the disinfectant composition-impregnated article may be either a substrate pre-impregnated with the disinfectant composition, or a dried substrate impregnated with the disinfectant composition immediately before use. Furthermore, the disinfectant composition-impregnated article may be used attached to a mop-like cleaning tool, or it may be held directly in the hand and used for wiping or cleaning the body.

[0050] When the disinfectant composition is pre-impregnated into the substrate, the impregnation rate of the disinfectant composition is preferably 100% by mass or more, more preferably 150% by mass or more, preferably 1,000% by mass or less, more preferably 500% by mass or less, and even more preferably 350% by mass or less, from the viewpoint of non-enveloped virus inactivation performance, per the mass of the substrate [i.e., based on the mass of the substrate in an unimpregnated (dry) state]. If the impregnation rate is 100% by mass or more, a sufficient disinfecting effect can be obtained. Furthermore, if the impregnation rate is 1,000% by mass or less, the disinfectant composition can be used without contacting target surfaces other than the disinfection surface. From the viewpoint of further improving the disinfecting effect, when the substrate is a substrate sheet, the basis weight of the disinfectant composition before impregnation is, for example, 50 g / m², from the viewpoint of the retention of the disinfectant composition required for disinfecting a certain area, the operability of the sheet, and cost. 2 Preferably, it should be 100g / m² or more. 2 It is more preferable that the amount be greater than or equal to 250 g / m². 2 Preferably, it is 150 g / m². 2 The following is more preferable:

[0051] When using an article impregnated with the disinfectant composition of the present invention, the disinfectant composition of the present invention may also be sprayed separately onto the surface to be disinfected or the article impregnated with the disinfectant composition. This method of use allows for disinfection of a wider area.

[0052] <Method for producing disinfectant compositions> The present invention involves mixing (A) ethanol [hereinafter referred to as component (A)], (B) one or more selected from gluconic acid and its alkali metal salts [hereinafter referred to as component (B)], and (C) a water-soluble polyhydric alcohol [hereinafter referred to as component (C)]. The present invention provides a method for producing a disinfectant composition containing (A) 40% to 95% by mass, (B) 0.20% to 3.0% by mass, and (C) 0.10% to 2.0% by mass, with a pH of 5.0 or less at 25°C. In the method for producing the disinfectant composition of the present invention, component (D) can be further mixed in. In the method for producing the disinfectant composition of the present invention, component (E) can be further mixed in. In the method for producing the disinfectant composition of the present invention, a pH adjuster (excluding acidic agents (components (B) and (D))) may be further mixed in. In the method for producing the disinfectant composition of the present invention, the amount of each component mixed and their mass ratio can be appropriately applied by replacing the content of each component with the amount of each component mixed, as described in the disinfectant composition of the present invention. In the method for producing the disinfectant composition of the present invention, the matters described above for the disinfectant composition of the present invention can be applied as appropriate. [Examples]

[0053] [Ingredients] The following components were used to prepare the disinfectant compositions shown in Table 1. <(A) component> • Ethanol (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.) <(B) component> • Gluconic acid: Gluconic acid solution (50% aqueous solution) (manufactured by Fuso Chemical Industries Co., Ltd.) <(C) component> Glycerin: Concentrated glycerin (manufactured by Kao Corporation) • Polyethylene glycol: Macrogol 6000 (weight-average molecular weight 8600, manufactured by Sanyo Chemical Industries, Ltd.) <(D) component> • Phosphoric acid: Phosphate (manufactured by Yoneyama Pharmaceutical Co., Ltd.) • Sulfuric acid: 0.5 mol / L sulfuric acid (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.) • Citric acid (manufactured by Fuso Chemical Industry Co., Ltd.) • Tartaric acid (manufactured by Fuso Chemical Industries Co., Ltd.)

[0054] [Method for preparing disinfectant compositions] According to the compositions shown in Table 1, each component was mixed at 25°C to obtain 800g of the disinfectant compositions for Examples 1-1 to 1-6 and Comparative Examples 1-1 to 1-5. Note that all component content values ​​in Table 1 represent effective amounts.

[0055] [Method for evaluating the inactivation effect of feline calicivirus] The virus inactivation test was conducted with reference to the "2015 Survey Report on Norovirus Inactivation Conditions" (National Institute of Health Sciences) and ASTM E1052, which are generally known as standard methods for evaluating virus inactivation. 90 μL of each disinfectant composition from Examples 1-1 to 1-6 and Comparative Examples 1-1 to 1-5, and 1.5 × 10 9 10 μL of feline calicivirus solution (F-9 strain, ATCC VR-782), adjusted to PFU / mL, was placed in an Eppendorf tube and thoroughly mixed. After mixing for 30 seconds at room temperature, the reaction was stopped by diluting the solution 1 / 10 with a quenching solution (SCDLP solution). As a blank, the same procedure was performed using 90 μL of distilled water instead of 90 μL of the disinfectant composition. After stopping the reaction, the mixture was further serially diluted at 10-fold intervals in HEPES-containing (hydroxyethylpiperazine ethanesulfonic acid-containing) DMEM medium (Dulbecc's modified Eagle medium). 0.5 mL of this solution was used to infect CRFK cells (feline kidney-derived cell line) (ATCC CCL-94) washed with PBS (phosphate-buffered saline), and after 1 hour, the medium was replaced with methylcellulose-containing medium. Two days later, the cells in each sample at a predetermined time were stained with crystal violet, the number of plaques was counted, and the logarithmic difference from the number of plaques in the blank was calculated as the logarithmic decrease value and evaluated according to the following criteria. A: Logarithmic decrease value of 4 or more B: The logarithmic decrease value is 3 or greater and less than 4. C: Logarithmic decrease value is 2 or greater and less than 3. D: Logarithmic decrease is less than 2

[0056] [Method for evaluating the effect of preventing rough hands] Ten panelists sprayed 3 mL of each hand sanitizer composition onto their hands, applied it to both hands, and allowed it to air dry. This procedure was repeated 10 times at 5-minute intervals. Skin irritation and the condition of the hands were observed until the following day, and the effectiveness in preventing skin irritation was evaluated as follows: no skin irritation or dryness was good, and the presence of skin irritation or dryness was bad.

[0057] Each panelist's evaluation was conducted according to the following criteria. 5: Very good 4: Good 3: I can't say either way. 2: Not very good 1: Not good

[0058] Table 1 shows the average evaluation results from 10 participants regarding the effectiveness in preventing rough hands.

[0059] [Table 1]

[0060] As shown in Table 1, the disinfectant compositions of Examples 1-1 to 1-6, which correspond to the present invention, had a sufficient effect in inactivating feline calicivirus and also had an effect in suppressing skin irritation. On the other hand, Comparative Example 1-1, which did not contain water-soluble polyhydric alcohol, and Comparative Examples 1-2 to 1-4, which did not contain gluconic acid, did not provide a sufficient effect in suppressing skin irritation. Furthermore, Comparative Example 1-5, which contained gluconic acid and water-soluble polyhydric alcohol but had a pH greater than 5, did not provide a sufficient effect inactivating feline calicivirus. Other examples include compositions in which, in addition to the disinfectant compositions of each example listed in Table 1, each contains glycyrrhetinic acid as a skin protectant, a known fatty acid triglyceride as an emollient, hydroxypropyl cellulose as a thickener, and one, two, three, or four components selected from the fragrance, each in an amount of 0.01% to 0.2% by mass. These are also products of the present invention.

Claims

1. A disinfectant composition containing (A) ethanol [hereinafter referred to as component (A)] in an amount of 40% to 95% by mass, (B) one or more selected from gluconic acid and its alkali metal salts [hereinafter referred to as component (B)] in an amount of 0.20% to 3.0% by mass, and (C) a water-soluble polyhydric alcohol [hereinafter referred to as component (C)] in an amount of 0.10% to 2.0% by mass, with a pH of 5.0 or less at 25°C.

2. The disinfectant composition according to claim 1, wherein the mass ratio (B) / (C) of the content of component (B) to the content of component (C) is 0.5 or more and 10 or less.

3. The disinfectant composition according to claim 1 or 2, further comprising (D) an acidifying agent [excluding component (B)].

4. A disinfectant composition according to claim 1 or 2, for use on the surface of the body.

5. A disinfectant composition-impregnated article in which the disinfectant composition according to claim 1 or 2 is impregnated into a substrate.

6. The disinfectant composition-impregnated article according to claim 5, wherein the substrate is a nonwoven fabric.

7. A method for inactivating non-enveloped viruses, comprising contacting the disinfectant composition according to claim 1 or 2 with a target surface where non-enveloped viruses are present.

8. The method for inactivating a non-enveloped virus according to claim 7, wherein the target surface is a body surface.

9. A method for inactivating non-enveloped viruses according to claim 7, comprising spraying or applying the disinfectant composition according to claim 1 or 2 to a target surface.

10. A method for inactivating a non-enveloped virus according to claim 7, comprising bringing an article impregnated with the disinfectant composition described in claim 5 into contact with a target surface.

11. (A) Ethanol [hereinafter referred to as component (A)], (B) One or more selected from gluconic acid and its alkali metal salts [hereinafter referred to as component (B)], and (C) Water-soluble polyhydric alcohol [hereinafter referred to as component (C)] are mixed together. A method for producing a disinfectant composition, comprising: (A) 40% to 95% by mass of component (A), (B) 0.20% to 3.0% by mass of component (B), and (C) 0.10% to 2.0% by mass of component (C), wherein the pH is 5.0 or less at 25°C.

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