Automatic analysis device

Abstract

The goal is to improve user convenience while achieving at least one of the following: miniaturization and cost reduction of automated analyzers. [Solution] The automated analyzer according to the embodiment comprises a detergent dispenser, a probe, a probe cleaning pool, a reaction tube cleaning nozzle, a detergent supply pump, and a first switching valve. The detergent dispenser is where the detergent container is placed. The probe dispenses at least one of the sample and the reagent. The probe cleaning pool cleans the probe. The reaction tube cleaning nozzle cleans the reaction tube in which the sample is contained. The detergent supply pump supplies detergent from the detergent container installed in the detergent dispenser to the detergent supply destination. The first switching valve switches the detergent supply destination. The detergent supply destination includes at least the probe cleaning pool and the reaction tube cleaning nozzle.

Description

Technical Field

[0001] The embodiments disclosed in this specification and the drawings relate to an automatic analyzer.

Background Art

[0002] An automatic analyzer is a device that analyzes the components of a test sample by optically and / or electrically measuring a reaction solution obtained by mixing a test sample such as a test sample collected from a subject such as blood or urine or a standard sample for each measurement item with a reagent corresponding to each measurement item. In such an automatic analyzer, a probe is inserted into a reagent container or a sample container, the reagent or sample contained in the container is aspirated, and the reagent or sample is dispensed into a reaction tube held on a reaction disk, whereby each measurement item is measured.

[0003] Normally, since different samples and / or different reagents are dispensed with the same probe, the probe is washed in a washing section every time it aspirates and discharges a sample or a reagent. Also, since the reaction tubes held on the reaction disk are repeatedly used, they are washed when the measurement of a sample is completed, and the washed reaction tubes are used for the measurement of the measurement items of subsequent samples.

[0004] Conventionally, an automatic analyzer is provided with separate detergent supply pumps for supplying a probe cleaning detergent to a probe cleaning pool and for supplying a reaction tube cleaning detergent to a reaction tube cleaning nozzle. For this reason, the number of parts of the automatic analyzer increases, leading to an increase in the size and cost of the automatic analyzer. Also, since a detergent bottle containing a probe cleaning detergent and a detergent bottle containing a reaction tube cleaning detergent are separately installed in the detergent installation section of the automatic analyzer, it is necessary to separately replenish the probe cleaning detergent and the reaction tube cleaning detergent, which also causes a problem of increasing the user's labor.

Prior Art Documents

Patent Documents

[0005] [Patent Document 1] Japanese Patent Publication No. 2008-202945 [Overview of the project] [Problems that the invention aims to solve]

[0006] One of the problems that the embodiments disclosed herein and in the drawings aim to solve is to improve user convenience while achieving at least one of miniaturization and cost reduction of automated analyzers. However, the problems that the embodiments disclosed herein and in the drawings aim to solve are not limited to the above problem. Problems corresponding to the effects of each configuration shown in the embodiments described later can also be positioned as other problems. [Means for solving the problem]

[0007] The automated analyzer according to this embodiment comprises a detergent dispenser, a probe, a probe cleaning pool, a reaction tube cleaning nozzle, a detergent supply pump, and a first switching valve. The detergent dispenser holds a detergent container. The probe dispenses at least one of a sample and a reagent. The probe cleaning pool cleans the probe. The reaction tube cleaning nozzle cleans the reaction tube containing the sample. The detergent supply pump supplies detergent from the detergent container installed in the detergent dispenser to a detergent supply destination. The first switching valve switches the detergent supply destination. The detergent supply destination includes at least the probe cleaning pool and the reaction tube cleaning nozzle. [Brief explanation of the drawing]

[0008] [Figure 1] This block diagram shows an example of the functional configuration of an automated analyzer according to the first embodiment. [Figure 2] This figure shows an example of the configuration of the analytical mechanism according to the first embodiment. [Figure 3] This figure shows an example of the configuration of the cleaning unit and drive mechanism of the automated analyzer according to the first embodiment. [Figure 4]This is a flowchart illustrating the contents of the detergent supply process performed in the automated analyzer according to the first embodiment. [Figure 5] This is a block diagram showing an example of the functional configuration of an automated analyzer according to the second embodiment. [Figure 6] This figure shows an example of reaction tube information for an automated analyzer according to the second embodiment. [Figure 7] This figure shows an example of a probe washing pool according to the second embodiment. [Figure 8] This figure shows an example of the measurement sequence of the automated analyzer according to the second embodiment. [Figure 9] This is a flowchart illustrating the contents of the detergent supply process performed in the automated analyzer according to the second embodiment. [Figure 10] This is a flowchart illustrating the contents of the detergent supply process performed in the automated analyzer according to the third embodiment. [Figure 11] This is a block diagram showing an example of the functional configuration of an automated analyzer according to the fourth embodiment. [Figure 12] This figure shows an example of the configuration of the cleaning section of an automated analyzer according to the fourth embodiment. [Modes for carrying out the invention]

[0009] The embodiments of the automated analyzer will be described below with reference to the drawings. In the following description, components having substantially the same function and configuration will be denoted by the same reference numeral, and redundant explanations will be given only when necessary.

[0010] [First Embodiment] Figure 1 is a block diagram showing an example of the functional configuration of an automated analyzer according to the first embodiment. As shown in Figure 1, the automated analyzer 1 according to this embodiment is configured to include, for example, an analysis mechanism 2, an analysis circuit 3, a drive mechanism 4, an input interface 5, an output interface 6, a communication interface 7, a memory circuit 8, and a control circuit 9.

[0011] Analytical mechanism 2 adds a reagent corresponding to the measurement item of the sample to a sample such as a standard sample or a test sample. Analytical mechanism 2 measures the mixture obtained by adding the reagent to the sample and generates, for example, standard data and test data. In this embodiment, the standard data represents the absorbance measurement result for a standard sample in which the concentration of the detectable substance is known. The test data represents the absorbance measurement result for the test sample. In the following, when standard samples and test samples are not distinguished, they may simply be referred to as "samples".

[0012] The analysis circuit 3 is a processor that generates calibration data and analytical data by analyzing the standard data and test data generated by the analysis mechanism 2. The analysis circuit 3 reads an analysis program from the memory circuit 8 and generates calibration data and analytical data according to the read analysis program. For example, the analysis circuit 3 generates standard data and calibration data that shows the relationship with pre-set standard values ​​for standard samples based on the standard data. The analysis circuit 3 also generates analytical data expressed as concentration values ​​and enzyme activity values ​​based on the test data and the calibration data for the test items corresponding to this test data. The analysis circuit 3 outputs the generated calibration data and analytical data to the control circuit 9.

[0013] The drive mechanism 4 drives the analysis mechanism 2 according to the control of the control circuit 9. For example, the drive mechanism 4 is implemented by gears, a stepping motor, a belt conveyor, and a lead screw. In this embodiment, the drive mechanism 4 includes a plunger movement mechanism, which will be described in detail later.

[0014] The input interface 5 receives settings such as analysis parameters for each measurement item related to a sample for which a measurement has been requested. The input interface 5 is realized, for example, by a mouse, a keyboard, and a touch pad through which an instruction is input by touching an operation surface. The input interface 5 is connected to the control circuit 9, converts an operation instruction input from a user into an electric signal, and outputs this electric signal to the control circuit 9. In this embodiment, the input interface 5 is not limited to only those having physical operation components such as a mouse and a keyboard. For example, an electric signal processing circuit that receives an electric signal corresponding to an operation instruction input from an external input device provided separately from the automatic analyzer 1 and outputs this electric signal to the control circuit 9 is also included in the example of the input interface 5.

[0015] The output interface 6 is connected to the control circuit 9 and outputs a signal supplied from the control circuit 9. The output interface 6 is realized, for example, by a display circuit, a printing circuit, and an audio device. The display circuit includes, for example, a CRT (Cathode Ray Tube) display, a liquid crystal display, an organic EL (Electro Luminescence) display, an LED display, and a plasma display. In addition, a processing circuit that converts data representing a display target into a video signal and outputs the video signal to the outside is also included in the display circuit. The printing circuit includes, for example, a printer and the like. In addition, an output circuit that outputs data representing a printing target to the outside is also included in the printing circuit. The audio device includes, for example, a speaker and the like. In addition, an output circuit that outputs an audio signal to the outside is also included in the audio device.

[0016] The communication interface 7 is connected to, for example, the in-hospital network NW, connecting the automatic analyzer 1 to the in-hospital network NW. The communication interface 7 performs data communication with the HIS (Hospital Information System) via the in-hospital network NW. Note that the communication interface 7 may perform data communication with the HIS via the clinical laboratory information system (Laboratory Information System: LIS) connected to the in-hospital network NW.

[0017] The memory circuit 8 is constituted by a recording medium such as a magnetic or optical recording medium, or a semiconductor memory or the like that can be read by a processor. This memory circuit 8 stores the analysis program executed by the analysis circuit 3 and the control program executed by the control circuit 9. Also, the memory circuit 8 stores the analysis data generated by the analysis circuit 3 for each measurement item. Note that the memory circuit 8 does not necessarily have to be realized by a single storage device. For example, the memory circuit 8 can also be realized by a plurality of storage devices. The memory circuit 8 corresponds to the storage unit in the present embodiment.

[0018] The control circuit 9 is a processor that functions as the center of the automatic analyzer 1. The control circuit 9 realizes the function corresponding to this operation program by executing the operation program stored in the memory circuit 8. Note that the control circuit 9 may have a storage area for storing at least a part of the data stored in the memory circuit 8.

[0019] Figure 2 shows an example of the configuration of the analysis mechanism 2 according to the first embodiment. As shown in Figure 2, the analysis mechanism 2 according to this embodiment is configured to include, for example, a reaction disk 201, a constant temperature unit 202, a sample disk 203, a first reagent storage unit 204, a second reagent storage unit 205, a sample dispensing arm 206, a sample dispensing probe 207, a first reagent dispensing arm 208, a first reagent dispensing probe 209, a second reagent dispensing arm 210, a second reagent dispensing probe 211, a first stirring unit 212, a second stirring unit 213, a photometric unit 214, and a washing unit 220.

[0020] The reaction disk 201 supports multiple reaction tubes 2011 arranged in an arc shape at predetermined intervals. The reaction disk 201 transports the multiple reaction tubes 2011 along a predetermined path. The reaction disk 201 performs the analysis of the reaction solution of the sample and reagent by repeating one cycle, where one rotation and one stop constitute one cycle. Specifically, during the analysis of the reaction solution of the sample and reagent, the reaction disk 201 is driven by the drive mechanism 4 to alternately rotate and stop at predetermined time intervals set as the cycle time, for example, about 4 seconds. The reaction tubes 2011 are made of, for example, glass, polypropylene (PP), or acrylic.

[0021] The constant temperature unit 202 stores a heat transfer medium set to a predetermined temperature. The constant temperature unit 202 raises and maintains the temperature of the reaction liquid contained in the reaction tube 2011 to a predetermined temperature by immersing the reaction tube 2011 in the stored heat transfer medium.

[0022] The sample disc 203 holds multiple sample containers for containing samples. The sample disc 203 is rotated by the drive mechanism 4, thereby transporting each sample container held on the sample disc 203 to a predetermined position. Note that this mechanism for transporting sample containers is not limited to the sample disc 203; instead, it may be configured with a rack sampler that transports a rack containing one or more sample containers to a predetermined position.

[0023] The first reagent storage room 204 keeps multiple reagent containers refrigerated, containing the first reagent which reacts with predetermined components contained in standard samples and test samples. The first reagent is a buffer solution containing, for example, bovine serum albumin (BSA). Reagent labels are affixed to the reagent containers. The reagent labels are printed with optical symbols representing reagent information. The optical symbols can be any pixel codes, such as one-dimensional pixel codes and two-dimensional pixel codes. The reagent information is information about the reagent contained in the reagent container and includes, for example, the reagent name, reagent manufacturer code, reagent item code, bottle type, bottle size, capacity, manufacturing lot number, and expiration date.

[0024] Furthermore, the first reagent storage room 204 keeps multiple standard sample containers containing standard samples refrigerated. Each of the multiple standard sample containers contains a standard sample of the same component but at different concentrations.

[0025] A reagent rack 2041 is rotatably mounted inside the first reagent storage room 204. The reagent rack 2041 holds multiple reagent containers and multiple standard sample containers arranged in a ring shape. The reagent rack 2041 is rotated by a drive mechanism 4. A reader (not shown) is also provided inside the first reagent storage room 204 to read reagent information from reagent labels attached to reagent containers. The read reagent information is stored in a memory circuit 8.

[0026] A first reagent aspiration position is set at a predetermined location on the first reagent storage room 204. The first reagent aspiration position is located, for example, at the intersection of the rotational trajectory of the first reagent dispensing probe 209 and the movement trajectory of the openings of the reagent containers and standard sample containers arranged in a ring shape on the reagent rack 2041.

[0027] The second reagent storage room 205 keeps multiple reagent containers refrigerated, each containing a second reagent that pairs with the first reagent in a two-reagent system. The second reagent is a solution containing a predetermined antigen or antibody contained in the sample, and an insoluble carrier, such as carrier particles, on which an antigen or antibody that binds or dissociates by a specific antigen-antibody reaction is immobilized. The antigen or antibody that binds or dissociates by the specific reaction may be an enzyme, substrate, aptamer, or receptor. A reagent rack 2051 is rotatably installed inside the second reagent storage room 205.

[0028] The reagent rack 2051 holds multiple reagent containers arranged in a ring shape. Note that standard sample containers containing standard samples may be kept refrigerated in the second reagent storage room 205. The reagent rack 2051 is rotated by the drive mechanism 4. The second reagent storage room 205 is also equipped with a reader (not shown) that reads reagent information from reagent labels attached to the reagent containers. The read reagent information is stored in the memory circuit 8.

[0029] A second reagent aspiration position is set at a predetermined location on the second reagent storage unit 205. The second reagent aspiration position is located, for example, at the intersection of the rotational trajectory of the second reagent dispensing probe 211 and the movement trajectory of the openings of the reagent containers arranged in a ring shape on the reagent rack 2051.

[0030] The sample dispensing arm 206 is positioned between the reaction disk 201 and the sample disk 203. The sample dispensing arm 206 is provided by a drive mechanism 4 so as to be able to move vertically up and down and rotate horizontally. The sample dispensing arm 206 holds a sample dispensing probe 207 at one end.

[0031] The sample dispensing probe 207 rotates along an arc-shaped rotational trajectory as the sample dispensing arm 206 rotates. A dispensing position for aspirating a sample from the sample container held on the sample disk 203 is provided on this rotational trajectory. Additionally, a sample discharge position for discharging the sample aspirated by the sample dispensing probe 207 into the reaction tube 2011 is provided on the rotational trajectory of the sample dispensing probe 207. The sample discharge position is located where the rotational trajectory of the sample dispensing probe 207 intersects with the movement trajectory of the reaction tube 2011 held on the reaction disk 201.

[0032] The sample dispensing probe 207 is driven by the drive mechanism 4 and moves vertically at the dispensing position or sample ejection position. The sample dispensing probe 207 also, under the control of the control circuit 9, aspirates a sample from the sample container held on the sample disk 203 at the dispensing position. Furthermore, under the control of the control circuit 9, the sample dispensing probe 207 ejects the aspirated sample into the reaction tube 2011 located directly below the sample ejection position. The sample dispensing probe 207 performs this series of aspiration and ejection operations once, for example, per cycle.

[0033] The first reagent dispensing arm 208 is located near the outer periphery of the first reagent storage chamber 204. The first reagent dispensing arm 208 is provided by a drive mechanism 4 so as to be able to move vertically up and down and rotate horizontally. The first reagent dispensing arm 208 holds the first reagent dispensing probe 209 at one end.

[0034] The first reagent dispensing probe 209 rotates along an arc-shaped rotational trajectory as the first reagent dispensing arm 208 rotates. The aforementioned first reagent aspiration position is located on this rotational trajectory. Furthermore, a first reagent dispensing position is set on the rotational trajectory of the first reagent dispensing probe 209 for dispensing the first reagent or standard sample aspirationed by the first reagent dispensing probe 209 into the reaction tube 2011. The first reagent dispensing position is located at the intersection of the rotational trajectory of the first reagent dispensing probe 209 and the movement trajectory of the reaction tube 2011 held by the reaction disk 201.

[0035] The first reagent dispensing probe 209 is driven by the drive mechanism 4 and moves vertically on its rotational trajectory at the first reagent aspiration position or the first reagent discharge position. The first reagent dispensing probe 209 also aspirates the first reagent or standard sample from the reagent container located directly below the first reagent aspiration position, according to the control circuit 9. The first reagent dispensing probe 209 also discharges the aspirated first reagent or standard sample into the reaction tube 2011 located directly below the first reagent discharge position, according to the control circuit 9. The first reagent dispensing probe 209 performs the series of aspiration and discharge operations once, for example, during one cycle.

[0036] The second reagent dispensing arm 210 is located near the outer periphery of the first reagent storage chamber 204. The second reagent dispensing arm 210 is provided by a drive mechanism 4 so as to be able to move vertically up and down and rotate horizontally. The second reagent dispensing arm 210 holds the second reagent dispensing probe 211 at one end.

[0037] The second reagent dispensing probe 211 rotates along an arc-shaped rotational trajectory as the second reagent dispensing arm 210 rotates. The aforementioned second reagent aspiration position is located on this rotational trajectory. Furthermore, a second reagent discharge position is set on the rotational trajectory of the second reagent dispensing probe 211 for dispensing the second reagent aspirationd by the second reagent dispensing probe 211 into the reaction tube 2011. The second reagent discharge position is located at the intersection of the rotational trajectory of the second reagent dispensing probe 211 and the movement trajectory of the reaction tube 2011 held by the reaction disk 201.

[0038] The second reagent dispensing probe 211 is driven by the drive mechanism 4 and moves vertically on its rotational trajectory at the second reagent aspiration position or the second reagent discharge position. The second reagent dispensing probe 211 also aspirates the second reagent from the reagent container located directly below the second reagent aspiration position, according to the control circuit 9. The second reagent dispensing probe 211 also discharges the aspirated second reagent into the reaction tube 2011 located directly below the second reagent discharge position, according to the control circuit 9. The second reagent dispensing probe 211 performs the series of aspiration and discharge operations once, for example, during one cycle.

[0039] In the following discussion, the term "probe" refers collectively to the three types of probes: the sample dispensing probe 207, the first reagent dispensing probe 209, and the second reagent dispensing probe 211.

[0040] The first stirring unit 212 is located near the outer circumference of the reaction disk 201. The first stirring unit 212 has a first stirring arm and a first stirring bar located at the tip of the first stirring arm. The first stirring unit 212 uses the first stirring bar to stir the reaction solution of the standard sample and the first reagent contained in the reaction tube 2011 located at the first stirring position on the reaction disk 201. The first stirring unit 212 also uses the first stirring bar to stir the reaction solution of the test sample and the first reagent contained in the reaction tube 2011 located at the first stirring position on the reaction disk 201.

[0041] The second stirring unit 213 is located near the outer circumference of the reaction disk 201. The second stirring unit 213 has a second stirring arm and a second stirring bar located at the tip of the second stirring arm. The second stirring unit 213 uses the second stirring bar to stir the reaction solution of the standard sample, the first reagent, and the second reagent contained in the reaction tube 2011 located at the second stirring position on the reaction disk 201. The second stirring unit 213 also uses the second stirring bar to stir the reaction solution of the test sample, the first reagent, and the second reagent contained in the reaction tube 2011 located at the second stirring position.

[0042] The photometric unit 214 optically measures the reaction solution of the sample, the first reagent, and the second reagent discharged into the reaction tube 2011. The photometric unit 214 has a light source 2141 and a photodetector 2142. The photometric unit 214 irradiates light from the light source according to the control circuit 9. The irradiated light enters the reaction tube 2011 from the first side wall and exits from the second side wall opposite the first side wall. The photometric unit 214 detects the light emitted from the reaction tube 2011 using the photodetector 2142. This photometric unit 214 corresponds to the photometric unit in this embodiment. The photodetector 2142 corresponds to the photodetector in this embodiment.

[0043] Specifically, for example, the photodetector 2142 is positioned on the optical axis of the light irradiated from the light source 2141 to the reaction tube 2011. The photodetector 2142 detects the light that has passed through the reaction solution of the standard sample, the first reagent, and the second reagent in the reaction tube 2011. The automated analyzer 1 acquires photometric data represented by the intensity of the light detected by the photodetector 2142. Then, the automated analyzer 1 generates standard data represented by absorbance based on measurement data acquired at predetermined timings from this photometric data. In addition, the photodetector 2142 detects the light that has passed through the reaction solution of the test sample, the first reagent, and the second reagent in the reaction tube 2011. The automated analyzer 1 acquires photometric data represented by the intensity of the light detected by the photodetector 2142. Then, the automated analyzer 1 generates test data represented by absorbance based on measurement data acquired at predetermined timings from this photometric data. The photometric unit 214 outputs the generated standard data and the test data to the analysis circuit 3.

[0044] The cleaning unit 220 cleans the inside of the reaction tube 2011 after the photometric unit 214 has finished measuring the reaction solution, and dries the cleaned reaction tube 2011. The cleaning unit 220 also cleans the probe.

[0045] Figure 3 shows an example of the configuration of the cleaning unit 220 and the drive mechanism 4 of the automatic analyzer 1 according to the first embodiment. As shown in Figure 3, the cleaning unit 220 includes a detergent installation unit 230, a detergent supply unit 240, a first flow path switching valve 251, a first supply destination switching valve 252, a second flow path switching valve 261, a second supply destination switching valve 262, a reaction tube cleaning unit 270, a drainage pump 280, and a probe cleaning unit 290. Also, as shown in Figure 3, the drive mechanism 4 includes a plunger moving mechanism 400.

[0046] The detergent dispenser 230 houses detergent bottles for storing detergent. Examples of detergent types include acidic detergents and alkaline detergents. In subsequent descriptions, when acidic and alkaline detergents are not distinguished, they will simply be referred to as detergents. Furthermore, in the example shown in Figure 3, the detergent dispenser 230 houses a diluent bottle for diluting the detergent. This diluent is used, for example, to dilute a high-concentration detergent to a predetermined concentration. Examples of diluents include pure water and deaerated water. In the example shown in Figure 3, the detergent dispenser 230 includes a first stand 231 for housing an alkaline detergent bottle 101 for storing alkaline detergent, a second stand 232 for housing an acidic detergent bottle 102 for storing acidic detergent, a third stand 233 for housing a first diluent bottle 103 for housing a first diluent for diluting alkaline detergent, and a fourth stand 234 for housing a second diluent bottle 104 for housing a second diluent for diluting acidic detergent. When the alkaline detergent bottle 101 and the acidic detergent bottle 102 are not distinguished, they will simply be referred to as detergent bottles. Similarly, when the first diluent bottle 103 and the second diluent bottle 104 are not distinguished, they will simply be referred to as diluent bottles. These detergent bottles correspond to the detergent containers in the first embodiment.

[0047] The detergent supply unit 240 is a collection of pumps that supply detergent. In the example shown in Figure 3, the detergent supply unit 240 includes an alkaline detergent supply pump 241, a first diluent supply pump 242, an acidic detergent supply pump 243, and a second diluent supply pump 244. When the alkaline detergent supply pump 241 and the acidic detergent supply pump 243 are not distinguished, they are simply referred to as detergent supply pumps. Similarly, when the first diluent supply pump 242 and the second diluent supply pump 244 are not distinguished, they are simply referred to as diluent supply pumps.

[0048] The detergent supply pump supplies detergent from the detergent bottle installed in the detergent installation section 230 to the detergent supply destination. Specifically, the alkaline detergent supply pump 241 is a pump for supplying alkaline detergent from the alkaline detergent bottle 101 to the detergent supply destination, and the acidic detergent supply pump 243 is a pump for supplying acidic detergent from the acidic detergent bottle 102 to the detergent supply destination. The detergent supply destination includes at least the probe cleaning pool of the probe cleaning section 290 and the reaction tube cleaning nozzle of the reaction tube cleaning section 270. In this embodiment, the detergent supply pump supplies detergent from the detergent bottle to the detergent supply destination once per cycle.

[0049] The diluent supply pump supplies the diluent from the diluent bottle installed in the detergent installation section 230 to the detergent supply destination. Specifically, the first diluent supply pump 242 is a pump for supplying the first diluent to the detergent supply destination, and the second diluent supply pump 244 is a pump for supplying the second diluent to the detergent supply destination. In this embodiment, the diluent supply pump, like the detergent supply pump, supplies the diluent from the diluent bottle to the detergent supply destination once per cycle.

[0050] In this embodiment, the detergent supply pump and the diluent supply pump are each syringe pumps. Specifically, in the example shown in Figure 3, the alkaline detergent supply pump 241, the first diluent supply pump 242, the acidic detergent supply pump 243, and the second diluent supply pump 244 are each syringe pumps.

[0051] The alkaline detergent supply pump 241 includes an alkaline detergent supply syringe 2411 and an alkaline detergent supply plunger 2412 inserted into the alkaline detergent supply syringe 2411 and movable in an entry direction (to enter the alkaline detergent supply syringe 2411) and an exit direction (to exit the alkaline detergent supply syringe 2411). The first diluent supply pump 242 includes a first diluent supply syringe 2421 and a first diluent supply plunger 2422 inserted into the first diluent supply syringe 2421 and movable in an entry direction (to enter the first diluent supply syringe 2421) and an exit direction (to exit the first diluent supply syringe 2421). Furthermore, the acid detergent supply pump 243 includes an acid detergent supply syringe 2431 and an acid detergent supply plunger 2432 inserted into the acid detergent supply syringe 2431 and movable in an entry direction, which is the direction in which the acid detergent supply syringe 2431 enters the acid detergent supply syringe 2431, and in an exit direction, which is the direction in which the acid detergent supply syringe 2431 exits the acid detergent supply syringe 2431. Furthermore, the second diluent supply pump 244 includes a second diluent supply syringe 2441 and a second diluent supply plunger 2442 inserted into the second diluent supply syringe 2441 and movable in an entry direction, which is the direction in which the acid detergent supply syringe 2441 enters the second diluent supply syringe 2441, and in an exit direction, which is the direction in which the acid detergent supply plunger 2442 exits the second diluent supply syringe 2441.

[0052] If the alkaline detergent supply syringe 2411 and the acidic detergent supply syringe 2431 are not distinguished, they will simply be referred to as the detergent supply syringe. Similarly, if the alkaline detergent supply plunger 2412 and the acidic detergent supply plunger 2432 are not distinguished, they will simply be referred to as the detergent supply plunger. Furthermore, if the first diluent supply syringe 2421 and the second diluent supply syringe 2441 are not distinguished, they will simply be referred to as the diluent supply syringe. In addition, if the first diluent supply plunger 2422 and the second diluent supply plunger 2442 are not distinguished, they will simply be referred to as the diluent supply plunger. This detergent supply syringe corresponds to the first syringe in this embodiment, the detergent supply plunger corresponds to the first plunger in this embodiment, the diluent supply syringe corresponds to the second syringe in this embodiment, and the diluent supply plunger corresponds to the second plunger in this embodiment.

[0053] The alkaline detergent supply plunger 2412, the first diluent supply plunger 2422, the acidic detergent supply plunger 2432, and the second diluent supply plunger 2442 are each moved in the entry and exit directions by the plunger movement mechanism 400 of the drive mechanism 4 under the control of the control circuit 9. In this embodiment, the alkaline detergent supply plunger 2412, the first diluent supply plunger 2422, the acidic detergent supply plunger 2432, and the second diluent supply plunger 2442 are each moved simultaneously in the entry and exit directions by the plunger movement mechanism 400.

[0054] The plunger moving mechanism 400 moves the detergent supply plunger in the detergent supply pump and the diluent supply plunger in the diluent supply pump under the control of the control circuit 9. The plunger moving mechanism 400 is composed of, for example, a motor and gears.

[0055] The first flow path switching valve 251 is installed between the first installation base 231 in the detergent installation section 230, the alkaline detergent supply pump 241, and the first supply destination switching valve 252. This first flow path switching valve 251 switches between supplying alkaline detergent from the alkaline detergent bottle 101 to the alkaline detergent supply pump 241, and supplying alkaline detergent from the alkaline detergent supply pump 241 to the first supply destination switching valve 252. This first flow path switching valve 251 is configured, for example, by a solenoid valve. Specifically, the first flow path switching valve 251 is configured, for example, by a three-way solenoid valve.

[0056] The first supply destination switching valve 252 switches the detergent supply destination for the alkaline detergent. In the example shown in Figure 3, the first supply destination switching valve 252, under the control of the control circuit 9, switches the detergent supply destination of the alkaline detergent and the first diluent supplied from the alkaline detergent supply pump 241 and the first diluent supply pump 242 between the reaction tube cleaning unit 270 and the probe cleaning unit 290. This first supply destination switching valve 252 is configured as, for example, a solenoid valve. Specifically, the first supply destination switching valve 252 is configured as, for example, a three-way solenoid valve.

[0057] The second flow path switching valve 261 is installed between the acid detergent supply pump 243 and the second supply destination switching valve 262. This second flow path switching valve 261 switches between supplying acid detergent from the acid detergent bottle 102 to the acid detergent supply pump 243 and supplying acid detergent from the acid detergent supply pump 243 to the second supply destination switching valve 262. This second flow path switching valve 261 is configured, for example, by a solenoid valve. Specifically, the second flow path switching valve 261 is configured, for example, by a three-way solenoid valve.

[0058] The second supply destination switching valve 262 switches the destination of the acidic detergent. In the example shown in Figure 3, the second supply destination switching valve 262, under the control of the control circuit 9, switches the destination of the acidic detergent and the second diluent supplied from the acidic detergent supply pump 243 and the second diluent supply pump 244 between the reaction tube cleaning unit 270 and the probe cleaning unit 290. This second supply destination switching valve 262 is configured as, for example, a solenoid valve. Specifically, the second supply destination switching valve 262 is configured as, for example, a three-way solenoid valve.

[0059] In the following, when the first flow path switching valve 251 and the second flow path switching valve 261 are not distinguished, they will simply be referred to as the flow path switching valve. This flow path switching valve corresponds to the second switching valve in this embodiment. Also, in the following, when the first supply destination switching valve 252 and the second supply destination switching valve 262 are not distinguished, they will simply be referred to as the supply destination switching valve. This supply destination switching valve corresponds to the first switching valve in this embodiment.

[0060] The reaction tube cleaning section 270 is a collection of nozzles equipped with predetermined piping. In the example shown in Figure 3, the reaction tube cleaning section 270 includes a first reaction tube cleaning nozzle 271 and a second reaction tube cleaning nozzle 272. The first reaction tube cleaning nozzle 271 and the second reaction tube cleaning nozzle 272 each clean the reaction tube 2011 in which the sample is contained. When the first reaction tube cleaning nozzle 271 and the second reaction tube cleaning nozzle 272 are not distinguished, they are simply referred to as the reaction tube cleaning nozzle.

[0061] The first reaction tube cleaning nozzle 271 cleans the reaction tube 2011 using an alkaline detergent supplied from the alkaline detergent supply pump 241. In this embodiment, the first reaction tube cleaning nozzle 271 cleans the reaction tube 2011 using an alkaline detergent diluted to a predetermined concentration by a first diluent supplied from the first diluent supply pump 242. As shown in Figure 3, the first reaction tube cleaning nozzle 271 is located above the reaction tube cleaning position W1, which is a position for cleaning the reaction tube 2011 held in the reaction disk 201. In other words, the first reaction tube cleaning nozzle 271 cleans the reaction tube 2011 located at the reaction tube cleaning position W1. In the example shown in Figure 3, the first reaction tube cleaning nozzle 271 includes a first discharge nozzle 2711 and a first suction nozzle 2712.

[0062] The first discharge nozzle 2711 discharges alkaline detergent supplied from the alkaline detergent supply pump 241 into the reaction tube 2011. In this embodiment, the first discharge nozzle 2711 discharges alkaline detergent diluted to a predetermined concentration with the first diluent. The first suction nozzle 2712 sucks up the alkaline detergent discharged from the first discharge nozzle 2711. Specifically, the first suction nozzle 2712 is connected to the drainage pump 280, and when the drainage pump 280 operates, it sucks up the alkaline detergent diluted to a predetermined concentration with the first diluent discharged from the first discharge nozzle 2711.

[0063] The second reaction tube cleaning nozzle 272 cleans the reaction tube 2011 using an acidic detergent supplied from the acidic detergent supply pump 243. In this embodiment, the second reaction tube cleaning nozzle 272 cleans the reaction tube 2011 using an acidic detergent diluted to a predetermined concentration by a second diluent supplied from the second diluent supply pump 244. As shown in Figure 3, the second reaction tube cleaning nozzle 272 is located above the reaction tube cleaning position W2, which is set to clean the reaction tube 2011 held on the reaction disk 201. In other words, the second reaction tube cleaning nozzle 272 cleans the reaction tube 2011 located at the reaction tube cleaning position W2. In the example shown in Figure 3, the second reaction tube cleaning nozzle 272 includes a second discharge nozzle 2721 and a second suction nozzle 2722.

[0064] The second discharge nozzle 2721 discharges the acidic detergent supplied from the acidic detergent supply pump 243 into the reaction tube 2011. In this embodiment, the second discharge nozzle 2721 discharges the acidic detergent diluted to a predetermined concentration with the second diluent. The second suction nozzle 2722 sucks up the acidic detergent discharged from the second discharge nozzle 2721. Specifically, the second suction nozzle 2722 is connected to the drainage pump 280, and when the drainage pump 280 operates, it sucks up the acidic detergent diluted to a predetermined concentration with the second diluent discharged from the second discharge nozzle 2721.

[0065] Although the reaction tube cleaning unit 270 includes a first reaction tube cleaning nozzle 271 and a second reaction tube cleaning nozzle, the nozzles included in the reaction tube cleaning unit 270 are not limited to the first reaction tube cleaning nozzle 271 and the second reaction tube cleaning nozzle. In other words, the nozzles included in the reaction tube cleaning unit 270 are arbitrary and may include a nozzle for cleaning the reaction tube 2011 with deionized water, a nozzle for discharging blank water, a nozzle for sucking up blank water, and a nozzle for supplying dry air.

[0066] Under the control of the control circuit 9, the drain pump 280 sucks a predetermined liquid contained in the reaction tube 2011 located at reaction tube cleaning position W1 and reaction tube cleaning position W2 through the first suction nozzle 2712 and the second suction nozzle 2722, respectively. The drain pump 280 then drains the sucked liquid into the drain tank.

[0067] The probe cleaning unit 290 is a collection of pools (containers) for storing detergent. In the example shown in Figure 3, the probe cleaning unit 290 comprises a first probe cleaning pool 291 and a second probe cleaning pool 292. The first probe cleaning pool 291 and the second probe cleaning pool 292 are pools for cleaning probes. When the first probe cleaning pool 291 and the second probe cleaning pool 292 are not distinguished, they are simply referred to as probe cleaning pools.

[0068] The first probe cleaning pool 291 stores alkaline detergent supplied from the alkaline detergent supply pump 241. In this embodiment, the first probe cleaning pool 291 stores alkaline detergent diluted to a predetermined concentration with the first diluent. The second probe cleaning pool 292 stores acidic detergent supplied from the acidic detergent supply pump 243. In this embodiment, the second probe cleaning pool 292 stores acidic detergent diluted to a predetermined concentration with the second diluent. The probe cleaning pool can store the amount of detergent used for one or more cleanings. In other words, the probe cleaning pool may store only the amount of detergent used for one cleaning, or it may store the amount of detergent used for multiple cleanings.

[0069] In this probe cleaning pool, the probe draws in the detergent stored in the pool. Then, in the drainage tank, the probe drains the drawn-in detergent. In this way, the inside of the probe is cleaned. Alternatively, when the probe drains the drawn-in detergent, the cleaning solution may be sprayed onto the outer surface of the probe to clean it as well.

[0070] In the example shown in Figure 3, the probe cleaning unit 290 is provided with one first probe cleaning pool 291 and one second probe cleaning pool 292. However, the number of first probe cleaning pools 291 and second probe cleaning pools 292 provided by the probe cleaning unit 290 is not limited to this. That is, the number of first probe cleaning pools 291 and second probe cleaning pools 292 provided by the probe cleaning unit 290 is arbitrary, and it may be provided with two or more first probe cleaning pools 291 and second probe cleaning pools 292, or the probe cleaning unit 290 may be provided with a number of first probe cleaning pools 291 and second probe cleaning pools 292 corresponding to the number of probes. Specifically, in the example shown in Figure 2, if the analytical mechanism 2 is equipped with three probes, a sample dispensing probe 207, a first reagent dispensing probe 209, and a second reagent dispensing probe 211, then three probe cleaning pools may be provided.

[0071] Returning to Figure 1, the control circuit 9 implements the functions corresponding to the control program stored in the memory circuit 8 by executing the program. For example, the control circuit 9 has a system control function 91, a switching valve control function 92, and a supply pump control function 93 by executing the control program. In this embodiment, the case in which the system control function 91, the switching valve control function 92, and the supply pump control function 93 are implemented by a single processor is described, but it is not limited to this. For example, the control circuit may be configured by combining multiple independent processors, and these various functions may be implemented by each processor executing a control program.

[0072] The system control function 91 is a function that comprehensively controls each part of the automatic analyzer 1 based on the input information received from the input interface 5. For example, in the system control function 91, the control circuit 9 controls the drive mechanism 4 and the analysis mechanism 2, and also controls the analysis circuit 3 to perform analysis according to the inspection items.

[0073] The switching valve control function 92 controls the supply destination switching valve. For example, the switching valve control function 92 controls the supply destination switching valve to switch the detergent supply destination. In this embodiment, the switching valve control function 92 also controls the flow path switching valve.

[0074] The supply pump control function 93 controls the detergent supply pump. The supply pump control function 93 also controls the diluent supply pump.

[0075] Furthermore, the system control function 91, the switching valve control function 92, and the supply pump control function 93 shown in Figure 1 constitute the system control unit, the first control unit, and the second control unit, respectively, in this embodiment.

[0076] Figure 4 is a flowchart illustrating the contents of the detergent supply process performed in the automatic analyzer 1 according to the first embodiment. In this detergent supply process, detergent is supplied to the probe cleaning pool or the reaction tube cleaning nozzle. This detergent supply process is performed once per cycle. Below, the cleaning supply process will be explained using the case where an alkaline detergent is supplied to the detergent supply destination as an example.

[0077] As shown in Figure 4, first, the switching valve control function 92 in the control circuit 9 of the automatic analyzer 1 switches the flow path switching valve in the direction that connects the detergent supply pump and the detergent bottle (step S11). Specifically, the switching valve control function 92 switches the first flow path switching valve 251 in the direction that connects the alkaline detergent supply pump 241 and the alkaline detergent bottle 101.

[0078] Next, as shown in Figure 4, the supply pump control function 93 in the control circuit 9 of the automatic analyzer 1 draws detergent into the detergent supply pump (step S13). Specifically, the supply pump control function 93 controls the plunger movement mechanism 400 of the drive mechanism 4 to move the alkaline detergent supply plunger 2412 of the alkaline detergent supply pump 241 in the exit direction, thereby drawing the alkaline detergent contained in the alkaline detergent bottle 101 into the alkaline detergent supply syringe 2411. In this embodiment, as the plunger movement mechanism 400 moves the alkaline detergent supply plunger 2412 in the exit direction, the first diluent supply plunger 2422 also moves in the exit direction, so that the degassed water, which is the first diluent, is drawn into the first diluent supply syringe 2421.

[0079] Next, as shown in Figure 4, the switching valve control function 92 switches the flow path switching valve in the direction that connects the detergent supply pump and the supply destination switching valve (step S15). Specifically, the switching valve control function 92 switches the first flow path switching valve 251 in the direction that connects the alkaline detergent supply pump 241 and the first supply destination switching valve 252.

[0080] Next, as shown in Figure 4, the switching valve control function 92 switches the supply destination switching valve in a direction that connects the detergent supply destination and the flow path switching valve (step S17). Specifically, the switching valve control function 92 switches the first supply destination switching valve 252 in a direction that connects the first flow path switching valve 251 to either the reaction tube cleaning nozzle of the reaction tube cleaning unit 270 or the probe cleaning pool of the probe cleaning unit 290, which are included in the detergent supply destination.

[0081] Next, as shown in Figure 4, the supply pump control function 93 supplies detergent to the detergent supply destination (step S19). Specifically, the supply pump control function 93 controls the plunger movement mechanism 400 of the drive mechanism 4 to move the alkaline detergent supply plunger 2412 of the alkaline detergent supply pump 241 in the inward direction, thereby supplying alkaline detergent from the alkaline detergent supply syringe 2411 into which the alkaline detergent is drawn, to the detergent supply destination connected by switching the first supply destination switching valve 252 in step S17. More specifically, the supply pump control function 93 controls the plunger movement mechanism 400 of the drive mechanism 4 to move the alkaline detergent supply plunger 2412 and the first diluent supply plunger 2422 in the inward direction, thereby supplying alkaline detergent diluted to a predetermined concentration with the first diluent to the detergent supply destination connected by switching the first supply destination switching valve 252 in step S17.

[0082] The detergent supply process in this embodiment is terminated when the process in step S19 is executed.

[0083] As described above, in the automatic analyzer 1 according to the first embodiment, a supply destination switching valve is provided to switch the detergent supply destination, including the probe cleaning pool of the probe cleaning unit 290 or the reaction tube cleaning nozzle of the reaction tube cleaning unit 270. Therefore, detergent can be supplied to both the probe cleaning pool and the reaction tube cleaning nozzle without having to separately provide a detergent supply pump for supplying detergent to the probe cleaning pool of the probe cleaning unit 290 and a detergent supply pump for supplying detergent to the reaction tube cleaning nozzle of the reaction tube cleaning unit 270. In other words, at least one of miniaturization and cost reduction of the automatic analyzer 1 can be achieved.

[0084] Furthermore, in the automatic analyzer 1 according to the first embodiment, a supply destination switching valve is provided to switch the detergent supply destination, including the probe cleaning pool of the probe cleaning unit 290 or the reaction tube cleaning nozzle of the reaction tube cleaning unit 270. As a result, the detergent bottles for storing the probe cleaning detergent and the detergent bottles for storing the reaction tube cleaning detergent do not need to be installed in separate detergent installation units 230, and only one location is required for detergent installation. This reduces the effort required for the user to replenish the detergent and improves user convenience.

[0085] [Second Embodiment] In the automatic analyzer 1 according to the first embodiment described above, it is also possible to determine whether or not it is necessary to supply detergent to the reaction tube 2011 according to the cleaning status of the reaction tube 2011, and if it is necessary to supply detergent to the reaction tube 2011, supply detergent to the reaction tube cleaning nozzle, and if it is not necessary to supply detergent to the reaction tube 2011, determine whether or not it is necessary to supply detergent to the probe cleaning pool according to the storage status of detergent in the probe cleaning pool, thereby switching the detergent supply destination. Hereinafter, the part that differs from the first embodiment will be described as the second embodiment when this modified example is applied to the first embodiment described above.

[0086] Figure 5 is a block diagram showing an example of the functional configuration of the automatic analyzer 1 according to the second embodiment, and corresponds to Figure 1. As shown in Figure 5, in the automatic analyzer 1 according to the second embodiment, the control circuit 9 is configured to additionally include a reaction tube information acquisition function 94, a detergent storage information acquisition function 95, and a reaction tube information recording function 96. The reaction tube information acquisition function 94, the detergent storage information acquisition function 95, and the reaction tube information recording function 96 are all functions that are realized by the control circuit 9 reading and executing a program stored in the memory circuit 8, similar to the other functions.

[0087] The reaction tube information acquisition function 94 acquires reaction tube information. The reaction tube information is information about reaction tube 2011. The reaction tube information acquired by the reaction tube information acquisition function 94 includes at least cleaning status information for the reaction tube at the cleaning position, which is the position where the reaction tube is cleaned. The reaction tube information may also include, for example, the reaction tube number corresponding to each reaction tube 2011 held in the reaction disk 201, the measurement items being measured in reaction tube 2011, information about the samples and reagents dispensed into the reaction tube, information about the type of detergent used to clean the reaction tube 2011, and information about the measurement sequence being executed. The cleaning status information is information about the cleaning status for each reaction tube number, and includes information on whether it is uncleaned or cleaned. This reaction tube information is stored, for example, in the memory circuit 8.

[0088] Figure 6 shows an example of reaction tube information for an automated analyzer according to the second embodiment. In the example shown in Figure 6, the reaction tube information IF1 stores the reaction tube number and cleaning status information related to the cleaning status of reaction tube 2011 in association with each other. The reaction tube number is a number assigned to each reaction tube 2011 stored on the reaction disk 201. Taking reaction tube number "1" in Figure 6 as an example, the cleaning status information is "Not cleaned". This means that the reaction tube 2011 corresponding to reaction tube number "1" is being used for measurement or is being cleaned. On the other hand, taking reaction tube number "2" as an example, the cleaning status information is "Cleaned". This means that the reaction tube 2011 corresponding to reaction tube number "2" has been cleaned, i.e., it is ready for measurement. In the example shown in Figure 6, the reaction tube numbers include 1 to 99, meaning that 99 reaction tubes 2011 are held in the reaction disk 201. However, the number of reaction tubes 2011 held in the reaction disk 201 is not limited to 99. That is, the number of reaction tubes 2011 held in the reaction disk 201 is arbitrary and may be 98 or less, or 100 or more.

[0089] The detergent storage information acquisition function 95 acquires detergent storage information. Detergent storage information is information regarding the storage status of detergent in the probe washing pool. Detergent storage information includes, for example, information regarding the type of detergent and the amount of detergent stored in the probe washing pool. Note that detergent storage information may also include other information.

[0090] Figure 7 shows an example of a probe cleaning pool according to the second embodiment. As shown in Figure 7, detection sensors 300 are attached to the probe cleaning pools 291 and 292 according to the second embodiment. These detection sensors 300 detect the detergent storage status in the probe cleaning pool as detergent storage information. In the second embodiment, the detergent storage information acquisition function 95 acquires the detection result of the detection sensor 300 as detergent storage information.

[0091] The reaction tube information recording function 96 records the cleaning status information in the memory circuit 8 when the cleaning status of the reaction tube 2011 changes. Here, a change in the cleaning status of the reaction tube 2011 refers to cases such as when a sample is dispensed into a reaction tube 2011 whose cleaning status information is cleaned, and the cleaning status of the reaction tube 2011 changes from cleaned to uncleaned, or when a cleaning process is performed on a reaction tube 2011 whose cleaning status information is uncleaned, and after the cleaning process is completed, the cleaning status of the reaction tube 2011 changes from uncleaned to cleaned.

[0092] Furthermore, the reaction tube information acquisition function 94, detergent storage information acquisition function 95, and reaction tube information recording function 96 shown in Figure 5 correspond to the reaction tube information acquisition unit, detergent storage information acquisition unit, and reaction tube information recording unit in this embodiment, respectively.

[0093] Figure 8 shows an example of a measurement sequence of the automated analyzer 1 according to the second embodiment. This Figure 8 shows a measurement sequence focusing on one reaction tube 2011 held in the reaction disk 201. In this measurement sequence, one phase proceeds per cycle. As shown in Figure 8, in Phase 1, the sample is dispensed into the cleaned reaction tube 2011. At this time, the reaction tube information recording function 96 records the cleaning status information of the reaction tube number corresponding to the reaction tube 2011 into which the sample was dispensed as "uncleaned". In other words, the cleaning status of the reaction tube 2011 changes from cleaned to uncleaned. Next, in Phase 2, the first reagent is dispensed into the reaction tube 2011. Next, in Phase 3, the first stirring is performed in the reaction tube 2011 into which the sample and the first reagent were dispensed. Next, in Phase 37, the second reagent is dispensed into the reaction tube 2011. Next, in Phase 38, a second stirring is performed in reaction tube 2011, which contains the sample, the first reagent, and the second reagent. After this, photometry is performed by the photometric unit 214 between Phase 38 and Phase 70.

[0094] Next, as shown in Figure 8, a cleaning process is performed on the reaction tube 2011 from Phase 71 onward. Specifically, in Phase 71, the high-concentration wastewater contained in the reaction tube 2011 is aspirated. Next, in Phase 75, cleaning is performed with an alkaline detergent. Next, in Phase 79, cleaning is performed with an acidic detergent. Next, in Phase 83, the first cleaning with DI (Deionization) water is performed. Next, in Phase 87, the second cleaning with DI (Deionization) water is performed. Next, in Phase 91, blank water is supplied and the photometric unit 214 measures the blank water. Next, in Phase 95, the water contained in the reaction tube 2011 is aspirated. Then, in Phase 99, the drying of the reaction tube 2011 is performed. At this time, the reaction tube information recording function 96 records the cleaning status information of the reaction tube number corresponding to the drying of the reaction tube 2011 as "cleaned". In other words, the cleaning status of reaction tube 2011 changes to cleaned. After the series of cleaning processes, including drying, is completed, reaction tube 2011 is reused for another measurement, and the sample is dispensed into reaction tube 2011 in Phase 1.

[0095] Furthermore, in Phase 1, if sample dispensing is not performed due to reasons such as not receiving a measurement request, the reaction tube information recording function 96 will not change the cleaning status information for the reaction tube number corresponding to reaction tube 2011. In other words, in Phase 1, the cleaning status information for the reaction tube number corresponding to reaction tube 2011, which has not been dispensed with sample, will remain "cleaned". Also, in Phase 71, if an uncleaned reaction tube 2011 is located at the reaction tube cleaning position W1 and alkaline detergent is not supplied to reaction tube 2011, the reaction tube information recording function 96 will not change the cleaning status information for the reaction tube number corresponding to reaction tube 2011. In other words, in Phase 71, the cleaning status information for the reaction tube number corresponding to reaction tube 2011, which has not been supplied with alkaline detergent, will remain "uncleaned".

[0096] Figure 9 is a flowchart illustrating the contents of the detergent supply process performed in the second embodiment, and corresponds to Figure 4. In the cleaning supply process according to this embodiment, it is determined whether or not it is necessary to supply detergent to the reaction tube 2011 based on the reaction tube information. If it is necessary to supply detergent to the reaction tube 2011, detergent is supplied to the reaction tube cleaning nozzle. If it is not necessary to supply detergent to the reaction tube 2011, it is determined whether or not it is necessary to supply detergent to the probe cleaning pool based on the detergent storage information. If it is necessary to supply detergent to the probe cleaning pool, detergent is supplied to the probe cleaning pool. This detergent supply process is performed once per cycle. In the following description, a series of flows of the detergent supply process when the reaction tube 2011 is located at the reaction tube cleaning position W1 will be described.

[0097] As shown in Figure 9, first, the reaction tube information acquisition function 94 in the control circuit 9 of the automatic analyzer 1 acquires reaction tube information (step S21). Specifically, the reaction tube information acquisition function 94 acquires the reaction tube information IF1 of the reaction tube 2011 of Phase 75, that is, the reaction tube 2011 located at the reaction tube cleaning position W1, from the memory circuit 8. In step S21, the reaction tube information acquisition function 94 may also acquire the reaction tube information of all reaction tubes 2011 held in the reaction disk 201 shown in Figure 7.

[0098] Next, as shown in Figure 9, the switching valve control function 92 in the control circuit 9 of the automatic analyzer 1 determines whether or not it is necessary to supply detergent to the reaction tube 2011 (step S23). Specifically, the switching valve control function 92 determines whether or not it is necessary to supply detergent to the reaction tube 2011 based on the reaction tube information IF1 acquired in step S21. More specifically, the switching valve control function 92 determines whether or not it is necessary to supply alkaline detergent to the reaction tube 2011 located at the reaction tube cleaning position W1 based on the cleaning status information included in the reaction tube information IF1 of the reaction tube 2011 located at the reaction tube cleaning position W1.

[0099] Then, in step S23, if the cleaning status information for reaction tube 2011 located at reaction tube cleaning position W1 indicates that it has not been cleaned, that is, if detergent needs to be supplied to reaction tube 2011 (step S23: Yes), the switching valve control function 92 switches the first flow path switching valve 251 in the direction that connects the detergent supply pump and the detergent bottle (step S11). Note that the processing from step S11 to step S15 onward is the same as in Figure 4, so the explanation is omitted.

[0100] Next, as shown in Figure 9, the switching valve control function 92 switches the supply destination switching valve in a direction that connects the reaction tube cleaning nozzle and the flow path switching valve (step S17a). Specifically, if it is necessary to supply detergent to the reaction tube 2011, the switching valve control function 92 controls the supply destination switching valve to switch the detergent supply destination to the reaction tube cleaning nozzle. More specifically, the switching valve control function 92 controls the first supply destination switching valve 252 to switch the detergent supply destination of the alkaline detergent to the first reaction tube cleaning nozzle 271.

[0101] Next, as shown in Figure 9, the supply pump control function 93 supplies detergent to the reaction tube cleaning nozzle (step S19a). Specifically, the supply pump control function 93 controls the plunger movement mechanism 400 of the drive mechanism 4 to move the alkaline detergent supply plunger 2412 of the alkaline detergent supply pump 241 in the inward direction, thereby supplying alkaline detergent from the alkaline detergent supply syringe 2411, into which the alkaline detergent is drawn, to the first reaction tube cleaning nozzle 271, which is connected by switching the first supply destination switching valve 252 in step S17a. More specifically, the supply pump control function 93 controls the plunger movement mechanism 400 of the drive mechanism 4 to move the alkaline detergent supply plunger 2412 and the first diluent supply plunger 2422 in the inward direction, thereby supplying alkaline detergent diluted to a predetermined concentration with the first diluent to the first reaction tube cleaning nozzle 271, which is connected by switching the first supply destination switching valve 252 in step S17a. Then, the first reaction tube cleaning nozzle 271 discharges alkaline detergent, supplying it to the reaction tube 2011 located at the reaction tube cleaning position W1.

[0102] On the other hand, in step S23, if the cleaning status information of the reaction tube located at the reaction tube cleaning position W1 indicates that it has been cleaned, that is, if it is not necessary to supply alkaline detergent to the reaction tube 2011 (step S23: No), the detergent storage information acquisition function 95 in the control circuit 9 of the automatic analyzer 1 acquires detergent storage information (step S25). Specifically, the detergent storage information acquisition function 95 acquires the detection result of the detection sensor 300 attached to the probe cleaning pool as detergent storage information. More specifically, the detergent storage information acquisition function 95 acquires the detection result of the detection sensor 300 attached to the first probe cleaning pool 291.

[0103] Next, as shown in Figure 9, the switching valve control function 92 determines whether or not it is necessary to supply detergent to the probe cleaning pool (step S27). Specifically, the switching valve control function 92 determines whether or not it is necessary to supply detergent to the probe cleaning pool based on the detergent storage information acquired in step S25. More specifically, the switching valve control function 92 determines whether or not it is necessary to supply detergent to the probe cleaning pool by determining whether or not the liquid level of the detergent stored in the probe cleaning pool can be detected based on the detection result of the detection sensor 300.

[0104] Then, in step S27, if the detergent level cannot be detected, that is, if it is necessary to supply detergent to the probe cleaning pool (step S27: Yes), the switching valve control function 92 switches the first flow path switching valve 251 in the direction that connects the detergent supply pump and the detergent bottle (step S11). Note that the processing from step S11 to step S15 onward is the same as in Figure 4, so the explanation is omitted.

[0105] Next, as shown in Figure 9, the switching valve control function 92 switches the supply destination switching valve in the direction that connects the probe cleaning pool and the flow path switching valve (step S17b). Specifically, if it is necessary to supply detergent to the first probe cleaning pool 291, the switching valve control function 92 controls the supply destination switching valve to switch the detergent supply destination to the first probe cleaning pool 291. More specifically, the switching valve control function 92 controls the first supply destination switching valve 252 to switch the detergent supply destination of the alkaline detergent to the first probe cleaning pool 291.

[0106] Next, as shown in Figure 9, the supply pump control function 93 supplies detergent to the probe cleaning pool (step S19b). Specifically, the supply pump control function 93 controls the plunger movement mechanism 400 of the drive mechanism 4 to move the alkaline detergent supply plunger 2412 of the alkaline detergent supply pump 241 in the inward direction, thereby supplying alkaline detergent from the alkaline detergent supply syringe 2411, into which the alkaline detergent is drawn, to the first probe cleaning pool 291, which is connected by switching the first supply destination switching valve 252 in step S17b. More specifically, the supply pump control function 93 controls the plunger movement mechanism 400 of the drive mechanism 4 to move the alkaline detergent supply plunger 2412 and the first diluent supply plunger 2422 in the inward direction, thereby supplying alkaline detergent diluted to a predetermined concentration with the first diluent to the first probe cleaning pool 291, which is connected by switching the first supply destination switching valve 252 in step S17b. Then, the first probe cleaning pool 291 discharges alkaline detergent, supplying alkaline detergent to the first probe cleaning pool 291.

[0107] On the other hand, in step S27, if the liquid level of the detergent can be detected, that is, if it is not necessary to supply detergent to the probe cleaning pool (step S27: No), if the process in step S19a is executed, or if the process in step S19b is executed, the detergent supply process in this embodiment is terminated.

[0108] As described above, in the automatic analyzer 1 according to the second embodiment, it is determined whether or not it is necessary to supply detergent to the reaction tube 2011 based on the reaction tube information, and if it is necessary to supply detergent to the reaction tube 2011, detergent is supplied to the reaction tube cleaning nozzle. If it is not necessary to supply detergent to the reaction tube 2011, it is determined whether or not it is necessary to supply detergent to the probe cleaning pool based on the detergent storage information, and if it is necessary to supply detergent to the probe cleaning pool, detergent is supplied to the probe cleaning pool. Therefore, detergent can be supplied to the probe cleaning pool and the reaction tube cleaning nozzle at the appropriate timing without having to separately provide a detergent supply pump for supplying detergent to the probe cleaning pool of the probe cleaning section and a detergent supply pump for supplying detergent to the reaction tube cleaning nozzle, thus making it possible to achieve at least one of miniaturization and cost reduction of the automatic analyzer 1.

[0109] [Third Embodiment] In the first and second embodiments described above, it is also possible to determine whether or not it is necessary to supply detergent to the probe cleaning pool according to the detergent storage status in the probe cleaning pool, and to supply detergent to the probe cleaning pool if it is necessary, and if it is not necessary to supply detergent to the probe cleaning pool, it is possible to determine whether or not it is necessary to supply detergent to the reaction tube according to the reaction tube information, and to supply detergent to the reaction tube cleaning nozzle if it is necessary. Below, the third embodiment will be described by applying this modification to the second embodiment described above, and the differences from the second embodiment will be explained, but this modification can also be applied to the first embodiment in the same way.

[0110] Figure 10 is a flowchart illustrating the contents of the detergent supply process performed in the automated analyzer according to the third embodiment, and corresponds to Figure 9. In the cleaning supply process according to this embodiment, it is determined whether or not it is necessary to supply detergent to the probe cleaning pool based on the detergent storage information. If it is necessary to supply detergent to the probe cleaning pool, detergent is supplied to the probe cleaning pool. If it is not necessary to supply detergent to the probe cleaning pool, it is determined whether or not it is necessary to supply detergent to the reaction tube 2011 based on the reaction tube information. If it is necessary to supply detergent to the reaction tube 2011, detergent is supplied to the reaction tube 2011. This detergent supply process is performed once per cycle. In the following description, a series of flows of the detergent supply process when the reaction tube 2011 is located at the reaction tube cleaning position W1 will be described.

[0111] As shown in Figure 10, first, the detergent storage information acquisition function 95 in the control circuit 9 of the automatic analyzer 1 acquires detergent storage information (step S31). Specifically, the detergent storage information acquisition function 95 acquires the detection result of the detection sensor 300 attached to the probe washing pool as detergent storage information. More specifically, the detergent storage information acquisition function 95 acquires the detection result of the detection sensor 300 attached to the first probe washing pool 291.

[0112] As shown in Figure 10, the switching valve control function 92 in the control circuit 9 of the automatic analyzer 1 determines whether or not it is necessary to supply detergent to the probe cleaning pool (step S33). Specifically, the switching valve control function 92 determines whether or not it is necessary to supply detergent to the probe cleaning pool based on the detergent storage information acquired in step S25. More specifically, the switching valve control function 92 determines whether or not it is necessary to supply detergent to the probe cleaning pool by determining whether or not the liquid level of the detergent stored in the probe cleaning pool can be detected based on the detection result of the detection sensor 300.

[0113] Then, in step S33, if the detergent level cannot be detected, that is, if it is necessary to supply detergent to the probe cleaning pool (step S33: Yes), the switching valve control function 92 switches the first flow path switching valve 251 in the direction that connects the detergent supply pump and the detergent bottle (step S11). Note that the processing from step S11 to step S15 is the same as in Figure 4, so the explanation is omitted.

[0114] Next, as shown in Figure 10, the switching valve control function 92 switches the supply destination switching valve in the direction that connects the probe cleaning pool and the flow path switching valve (step S17b). Specifically, if it is necessary to supply detergent to the probe cleaning pool, the switching valve control function 92 controls the supply destination switching valve to switch the detergent supply destination to the probe cleaning pool. More specifically, the switching valve control function 92 controls the first supply destination switching valve 252 to switch the detergent supply destination of the alkaline detergent to the first probe cleaning pool 291.

[0115] Next, as shown in Figure 10, the supply pump control function 93 supplies detergent to the probe cleaning pool (step S19b). Specifically, the supply pump control function 93 controls the plunger movement mechanism 400 of the drive mechanism 4 to move the alkaline detergent supply plunger 2412 of the alkaline detergent supply pump 241 in the inward direction, thereby supplying alkaline detergent from the alkaline detergent supply syringe 2411, into which the alkaline detergent is drawn, to the first probe cleaning pool 291, which is connected by switching the first supply destination switching valve 252 in step S17b. More specifically, the supply pump control function 93 controls the plunger movement mechanism 400 of the drive mechanism 4 to move the alkaline detergent supply plunger 2412 and the first diluent supply plunger 2422 in the inward direction, thereby supplying alkaline detergent diluted to a predetermined concentration with the first diluent to the first probe cleaning pool 291, which is connected by switching the first supply destination switching valve 252 in step S17b. Then, the first probe cleaning pool 291 discharges alkaline detergent, supplying alkaline detergent to the first probe cleaning pool 291.

[0116] On the other hand, in step S33, if the detergent level can be detected, that is, if it is not necessary to supply detergent to the probe cleaning pool (step S33: No), the reaction tube information acquisition function 94 in the control circuit 9 of the automatic analyzer 1 acquires reaction tube information (step S35). Specifically, the reaction tube information acquisition function 94 acquires the reaction tube information IF1 of the reaction tube 2011 of Phase 75, that is, the reaction tube 2011 located at the reaction tube cleaning position W1, from the memory circuit 8. In step S21, the reaction tube information acquisition function 94 may also acquire the reaction tube information of all reaction tubes 2011 held in the reaction disk 201 shown in Figure 7.

[0117] Next, as shown in Figure 10, the switching valve control function 92 determines whether or not it is necessary to supply detergent to the reaction tube 2011 (step S37). Specifically, the switching valve control function 92 determines whether or not it is necessary to supply detergent to the reaction tube 2011 based on the reaction tube information IF1 acquired in step S21. More specifically, the switching valve control function 92 determines whether or not it is necessary to supply alkaline detergent to the reaction tube 2011 located at the reaction tube cleaning position W1 based on the cleaning status information included in the reaction tube information IF1 of the reaction tube 2011 located at the reaction tube cleaning position W1.

[0118] Then, in step S37, if the cleaning status information for reaction tube 2011 located at reaction tube cleaning position W1 indicates that it has not been cleaned, that is, if detergent needs to be supplied to reaction tube 2011 (step S37: Yes), the switching valve control function 92 switches the first flow path switching valve 251 in the direction that connects the detergent supply pump and the detergent bottle (step S11). Note that the processing from step S11 to step S15 onward is the same as in Figure 4, so the explanation is omitted.

[0119] Next, as shown in Figure 10, the switching valve control function 92 switches the supply destination switching valve in a direction that connects the reaction tube cleaning nozzle and the flow path switching valve (step S17a). Specifically, if it is necessary to supply detergent to the reaction tube 2011, the switching valve control function 92 controls the supply destination switching valve to switch the detergent supply destination to the reaction tube cleaning nozzle. More specifically, the switching valve control function 92 controls the first supply destination switching valve 252 to switch the detergent supply destination of the alkaline detergent to the first reaction tube cleaning nozzle 271.

[0120] Next, as shown in Figure 10, the supply pump control function 93 supplies detergent to the reaction tube cleaning nozzle (step S19a). Specifically, the supply pump control function 93 controls the plunger movement mechanism 400 of the drive mechanism 4 to move the alkaline detergent supply plunger 2412 of the alkaline detergent supply pump 241 in the inward direction, thereby supplying alkaline detergent from the alkaline detergent supply syringe 2411, into which the alkaline detergent is drawn, to the first reaction tube cleaning nozzle 271, which is connected by switching the first supply destination switching valve 252 in step S17a. More specifically, the supply pump control function 93 controls the plunger movement mechanism 400 of the drive mechanism 4 to move the alkaline detergent supply plunger 2412 and the first diluent supply plunger 2422 in the inward direction, thereby supplying alkaline detergent diluted to a predetermined concentration with the first diluent to the first reaction tube cleaning nozzle 271, which is connected by switching the first supply destination switching valve 252 in step S17a. Then, the first reaction tube cleaning nozzle 271 discharges alkaline detergent, supplying it to the reaction tube 2011 located at the reaction tube cleaning position W1.

[0121] On the other hand, in step S37, if it is not necessary to supply detergent to the reaction tube 2011 (step S37: No), if the process in step S19a is performed, or if the process in step S19b is performed, the detergent supply process in this embodiment is terminated.

[0122] As described above, in the automatic analyzer 1 according to the third embodiment, it is determined whether or not it is necessary to supply detergent to the probe cleaning pool based on detergent storage information, and if it is necessary to supply detergent to the probe cleaning pool, detergent is supplied to the probe cleaning pool. If it is not necessary to supply detergent to the probe cleaning pool, it is determined whether or not it is necessary to supply detergent to the reaction tube 2011 based on reaction tube information, and if it is necessary to supply detergent to the reaction tube 2011, detergent is supplied to the reaction tube cleaning nozzle. As a result, detergent can be supplied to the probe cleaning pool in a timely manner, and the probe cleaning pool can be miniaturized, thereby achieving at least one of miniaturization and cost reduction of the automatic analyzer 1.

[0123] [Fourth Embodiment] In the automatic analyzer 1 according to the first to third embodiments described above, the supply pump control function can also independently control the detergent supply pump and the diluent supply pump. Below, the fourth embodiment will be described as the case in which this modification is applied to the first embodiment, and the differences from the first embodiment will be explained, but this modification can also be applied to the second and third embodiments.

[0124] Figure 11 is a block diagram showing an example of the functional configuration of the automatic analyzer 1 according to the fourth embodiment, and corresponds to Figure 1. As shown in Figure 11, the function of the supply pump control function differs from that of the first embodiment, and is therefore referred to as the supply pump control function 93a. Note that the configuration and functions other than the supply pump control function 93a are the same as those in Figure 11 of the first embodiment described above, and therefore their explanation is omitted.

[0125] The supply pump control function 93a independently controls the detergent supply pump and the diluent supply pump. In this embodiment as well, similar to the first embodiment described above, the detergent supply pump and the diluent supply pump are syringe pumps. The supply pump control function 93a independently controls the detergent supply plunger moving mechanism for moving the detergent supply plunger of the detergent supply pump, which will be described later, and the diluent supply plunger moving mechanism for moving the diluent supply plunger of the diluent supply pump, respectively.

[0126] Furthermore, the supply pump control function 93a controls the detergent supply pump and the diluent supply pump so that the detergent concentration differs depending on the detergent supply destination. Specifically, the supply pump control function 93a controls the detergent supply plunger movement mechanism for moving the detergent supply plunger and the diluent supply plunger movement mechanism for moving the diluent supply plunger, respectively, depending on the detergent supply destination, thereby causing the detergent concentration to differ depending on the detergent supply destination. More specifically, the supply pump control function 93a controls the amount of movement of the detergent supply plunger inserted into the detergent syringe in the inward or outward direction, and / or the amount of movement of the diluent supply plunger inserted into the diluent supply syringe in the inward or outward direction, depending on the detergent supply destination, thereby causing the detergent concentration to differ depending on the detergent supply destination.

[0127] The detergent supply syringe corresponds to the first syringe in this embodiment, and the diluent supply syringe corresponds to the second syringe in this embodiment. Furthermore, the detergent supply plunger corresponds to the first plunger in this embodiment, and the diluent supply plunger corresponds to the second plunger in this embodiment.

[0128] Figure 12 is a diagram showing an example of the configuration of the cleaning unit 220 of the automatic analyzer 1 according to the fourth embodiment, and corresponds to Figure 3. As shown in Figure 12, the drive mechanism 4 according to the fourth embodiment differs from the drive mechanism 4 according to the first embodiment described above in that, instead of the plunger moving mechanism 400, it includes a first detergent supply plunger moving mechanism 401, a first diluent supply plunger moving mechanism 402, a second detergent supply plunger moving mechanism 403, and a second diluent supply plunger moving mechanism 404. Note that the configuration of the cleaning unit 220 is the same as in Figure 3, so its explanation is omitted.

[0129] The first detergent supply plunger moving mechanism 401 moves the alkaline detergent supply plunger 2412. Specifically, the first detergent supply plunger moving mechanism 401 moves the alkaline detergent supply plunger 2412 in the direction of entry and exit of the alkaline detergent supply syringe 2411 under the control of the supply pump control function 93a. The first diluent supply plunger moving mechanism 402 moves the first diluent supply plunger 2422. Specifically, the first diluent supply plunger moving mechanism 402 moves the first diluent supply plunger 2422 in the direction of entry and exit of the first diluent supply syringe 2421 under the control of the supply pump control function 93a.

[0130] The second detergent supply plunger moving mechanism 403 moves the acid detergent supply plunger 2432. Specifically, the second detergent supply plunger moving mechanism 403 moves the acid detergent supply plunger 2432 in the direction of entry and exit of the acid detergent supply syringe 2431 under the control of the supply pump control function 93a. The second diluent supply plunger moving mechanism 404 moves the second diluent supply plunger 2442. Specifically, the second diluent supply plunger moving mechanism 404 moves the second diluent supply plunger 2442 in the direction of entry and exit of the second diluent supply syringe 2441 under the control of the supply pump control function 93a.

[0131] When the first detergent supply plunger moving mechanism 401 and the second detergent supply plunger moving mechanism 403 are not distinguished, they will simply be referred to as the detergent supply plunger moving mechanism. Similarly, when the first diluent supply plunger moving mechanism 402 and the second diluent supply plunger moving mechanism 404 are not distinguished, they will simply be referred to as the diluent supply plunger moving mechanism. This detergent supply plunger moving mechanism corresponds to the first plunger moving mechanism in this embodiment, and the diluent supply plunger moving mechanism corresponds to the second plunger moving mechanism in this embodiment.

[0132] With this configuration, in step S13 of the detergent supply process shown in Figure 4, the supply pump control function 93a controls the detergent supply plunger movement mechanism to draw detergent into the detergent supply pump, and also controls the diluent supply plunger to draw in the amount of diluent necessary to dilute the detergent to a predetermined concentration according to the detergent supply destination into the diluent supply pump. Then, in step S19 of the detergent supply process shown in Figure 4, the supply pump control function 93a controls the detergent supply plunger movement mechanism and the diluent supply plunger to discharge the detergent and diluent from the detergent supply syringe and the diluent supply syringe, mix the detergent and diluent in the flow path, and supply the detergent diluted to a concentration according to the detergent supply destination to the detergent supply destination.

[0133] As described above, in the automatic analyzer 1 according to the fourth embodiment, the supply pump control function 93a independently controls the detergent supply pump and the diluent supply pump, so that detergent diluted to an appropriate concentration can be supplied according to the detergent supply destination.

[0134] [Other variations] In the automatic analyzer 1 of the second and third embodiments described above, the switching valve control function 92 can also control the supply destination switching valve to switch the detergent supply destination to the probe washing pool when it is necessary to supply detergent to the probe washing pool, specifically when the probe has been washed a predetermined number of times or more after the detergent level in the probe washing pool has become undetectable, that is, when the probe has been washed a predetermined number of times or more after the detection result of the detection sensor 300 has turned OFF.

[0135] Furthermore, the automatic analyzer 1 in the second and third embodiments described above may be equipped with a liquid level detection unit that detects the liquid level of the detergent stored in the probe cleaning pool, instead of a detection sensor. One end of this liquid level detection unit is electrically connected to the probe. The liquid level detection unit includes an oscillation circuit, a bridge circuit, a differential amplifier, a synchronous detection circuit, an integrating circuit, and an amplification circuit, etc. The liquid level detection unit detects the probe's contact with the detergent in the probe cleaning pool, for example, by a change in capacitance (change in potential) when the probe comes into contact with the detergent in the probe cleaning pool. The liquid level detection unit outputs a detection signal regarding the probe's contact to the control circuit 9. Furthermore, if the automatic analyzer 1 is equipped with a liquid level detection unit, in steps S25 and S31 of the detergent supply process according to the second and third embodiments, the detergent storage information acquisition function 95 may acquire a liquid level detection result as detergent storage information, which is the result of the liquid level of the detergent being detected by the liquid level detection unit, and in steps S27 and S33 of the detergent supply process according to the second and third embodiments, the switching valve control function 92 may determine whether or not to supply detergent to the probe washing pool based on the liquid level detection result.

[0136] Furthermore, in the first to fourth embodiments described above, a diluent bottle was installed in the detergent installation section 230, and the diluent supply pump drew the diluent from the bottle. However, the diluent supply pump may draw the diluent from a pure water purification device instead of the diluent bottle. In this case, the detergent installation section 230 does not need to have an installation stand for the diluent bottle. As described above, by drawing the diluent from a pure water device, the user's hassle of replacing the diluent bottle can be reduced.

[0137] Furthermore, in the automatic analyzer 1 according to the first to fourth embodiments described above, an alkaline detergent bottle 101 and an acidic detergent bottle 102 are provided, and the case in which both alkaline detergent and acidic detergent are supplied to the detergent supply destination has been described. However, the automatic analyzer 1 does not have to supply both alkaline detergent and acidic detergent. In other words, in the automatic analyzer according to the first to fourth embodiments described above, either the alkaline detergent bottle 101 or the acidic detergent bottle 102 may be provided, and either the alkaline detergent or the acidic detergent may be supplied.

[0138] Furthermore, in the automatic analyzer 1 according to the first to fourth embodiments described above, the detergent bottle and the dilution bottle are provided separately. However, a detergent bottle containing detergent pre-diluted to a predetermined concentration may be installed in the detergent installation section 230, and the pre-diluted detergent may be supplied from this detergent bottle to the detergent supply destination. In this case, the automatic analyzer 1 does not need to be equipped with the third installation stand 233 and the fourth installation stand 234, the dilution solution supply pump, or the flow path switching valve. This makes it possible to achieve at least one of further miniaturization and cost reduction of the automatic analyzer.

[0139] Furthermore, in the first to fourth embodiments described above, the detergent supply pump and the diluent supply pump were defined as syringe pumps, but the invention is not limited to this. Various pumps capable of sucking and discharging fluids may be used for the detergent supply pump and the diluent supply pump.

[0140] Furthermore, in the first to fourth embodiments described above, the detergent supply pump can also supply detergent from the detergent bottle to the detergent supply destination two or more times per cycle. Specifically, in the automatic analyzer 1 with a long cycle time, the detergent supply process is performed two or more times per cycle, so the detergent supply pump can also supply detergent from the detergent bottle to the detergent supply destination two or more times per cycle.

[0141] Furthermore, in the automatic analyzer 1 according to the second and third embodiments described above, if multiple probe cleaning pools are provided, the detergent storage information acquisition function 95 may acquire detergent storage information for each of the multiple probe cleaning pools in steps S25 and S31 of the detergent supply process, and the switching valve control function 92 may determine whether or not to supply detergent to the probe cleaning pools based on the multiple detergent storage information. Specifically, the switching valve control function 92 may determine that detergent supply to the probe cleaning pools is necessary if, based on the multiple detergent storage information, one of the multiple probe cleaning pools requires detergent supply. If it is determined that detergent supply to multiple probe cleaning pools is necessary, the switching valve control function 92 may select the probe cleaning pool with the highest priority or the probe cleaning pool with the least amount of detergent stored as the destination for detergent supply.

[0142] Furthermore, in the first to fourth embodiments described above, the flow path switching valve and the supply destination switching valve are configured as solenoid valves, but the flow path switching valve and the supply destination switching valve are not limited to solenoid valves. Other types of valves may be used as switching valves for the flow path switching valve and the supply destination switching valve.

[0143] Furthermore, in the first to fourth embodiments described above, the detergent supply destinations include the probe cleaning pool and the reaction cleaning nozzle, but are not limited to these. That is, the detergent supply destinations are arbitrary and may include detergent supply destinations other than the probe cleaning pool and the reaction cleaning nozzle.

[0144] In the above explanation, the term "processor" refers to circuits such as a CPU (Central Processing Unit), a GPU (Graphics Processing Unit), an Application Specific Integrated Circuit (ASIC), or a programmable logic device (e.g., a Simple Programmable Logic Device (SPLD), a Complex Programmable Logic Device (CPLD), and a Field Programmable Gate Array (FPGA)). The processor functions by reading and executing a program stored in the memory circuit 8. Alternatively, instead of storing the program in the memory circuit 8, the processor may be configured to directly incorporate the program into its circuitry. In this case, the processor functions by reading and executing the program incorporated into the circuitry. The processor is not limited to being a single circuit; it may also be composed of multiple independent circuits combined to form a single processor and achieve its functions. Furthermore, multiple components may be integrated into a single processor to achieve its functions.

[0145] According to at least one embodiment described above, it is possible to improve user convenience while achieving at least one of miniaturization and cost reduction of the automated analyzer.

[0146] While several embodiments and variations have been described, these embodiments and variations are presented as examples only and are not intended to limit the scope of the invention. These embodiments and variations can be implemented in a variety of other forms, and various omissions, substitutions, modifications, and combinations of embodiments and variations can be made without departing from the spirit of the invention. These embodiments and variations are included in the scope and spirit of the invention, as well as in the claims and their equivalents. [Explanation of Symbols]

[0147] 1...Automatic analyzer, 2, 2a, 2b...Analysis mechanism, 3...Analysis circuit, 4...Drive mechanism, 5...Input interface, 6...Output interface, 7...Communication interface, 8...Memory circuit, 9...Control circuit, 91...System control function, 92...Switching valve control function, 93...Supply pump control function, 93a...Supply pump control function, 94...Reaction tube information acquisition function, 95...Detergent storage information acquisition function, 96...Reaction tube information recording function, 101...Alkaline detergent bottle, 10 2… Acid detergent bottle, 103… First diluent bottle, 104… Second diluent bottle, 201… Reaction disc, 202… Constant temperature section, 203… Sample disc, 204… First reagent storage, 205… Second reagent storage, 206… Sample dispensing arm, 207… Sample dispensing probe, 208… First reagent dispensing arm, 209… First reagent dispensing probe, 210… Second reagent dispensing arm, 211… Second reagent dispensing probe, 212… First stirring unit, 213… Second stirring unit Knit, 214…Photometric unit, 220…Washing unit, 230…Detergent dispenser, 231…First stand, 232…Second stand, 233…Third stand, 234…Fourth stand, 240…Detergent supply unit, 241…Alkaline detergent supply pump, 242…First dilution supply pump, 243…Acid detergent supply pump, 244…Second dilution supply pump, 251…First flow path switching valve, 252…First supply destination switching valve, 261…Second flow path switching valve, 262…Second supply destination switching valve, 270 ...Reaction tube cleaning section, 271...First reaction tube cleaning nozzle, 272...Second reaction tube cleaning nozzle, 280...Drainage pump, 290...Probe cleaning section, 291...First probe cleaning pool, 292...Second probe cleaning pool, 300...Detection sensor, 400...Plunger movement mechanism, 401...First detergent supply plunger movement mechanism, 402...First diluent supply plunger movement mechanism, 403...Second detergent supply plunger movement mechanism, 404...Second diluent supply plunger movement mechanism

Claims

1. A detergent holder section for installing the detergent container, A probe for dispensing at least one of the sample and reagent, A probe washing pool for washing the aforementioned probe, A reaction tube cleaning nozzle for cleaning the reaction tube containing the sample, A detergent supply pump installed in the detergent installation section supplies detergent from the detergent container to the detergent supply destination, A first switching valve for switching the detergent supply destination, Equipped with, The detergent supply destination is an automated analyzer that includes at least the probe cleaning pool and the reaction tube cleaning nozzle.

2. The automatic analyzer according to claim 1, wherein the detergent supply pump supplies the detergent from the detergent container to the detergent supply destination at least once per cycle.

3. The automatic analyzer according to claim 1, further comprising a first control unit for controlling the first switching valve.

4. The system further includes a detergent storage information acquisition unit that acquires detergent storage information regarding the storage status of the detergent in the probe washing pool, The first control unit is, Based on the detergent storage information, it is determined whether or not it is necessary to supply the detergent to the probe cleaning pool. When it is necessary to supply the detergent to the probe cleaning pool, the first switching valve is controlled to switch the detergent supply destination to the probe cleaning pool. The automated analyzer according to claim 3.

5. The probe cleaning pool is further equipped with a detection sensor that is attached to the probe cleaning pool and detects the storage status of the detergent in the probe cleaning pool, The detergent storage information acquisition unit acquires the detection result of the detection sensor as the detergent storage information, The first control unit determines, based on the detection result of the detection sensor, whether or not it is necessary to supply the detergent to the probe cleaning pool. The automated analyzer according to claim 4.

6. The automatic analyzer according to claim 5, wherein the first control unit controls the first switching valve to switch the detergent supply destination to the probe washing pool when it is necessary to supply the detergent to the probe washing pool, in the case that the probe has been washed a predetermined number of times or more after the detection result of the detection sensor has turned OFF.

7. The device further comprises a liquid level detection unit, one end of which is electrically connected to the probe, for detecting the liquid level of the detergent stored in the probe cleaning pool. The detergent storage information acquisition unit acquires the liquid level detection result, which is the result of the liquid level of the detergent detected by the liquid level detection unit, as the detergent storage information. The first control unit determines, based on the liquid level detection result, whether or not it is necessary to supply the detergent to the probe cleaning pool. The automated analyzer according to claim 4.

8. The system further includes a reaction tube information acquisition unit that acquires reaction tube information, which includes at least cleaning status information regarding the cleaning status of the reaction tube located at a reaction tube cleaning position, which is a position for cleaning the reaction tube. The first control unit is, If it is not necessary to supply the detergent to the probe cleaning pool, then it is determined whether or not it is necessary to supply the detergent to the reaction tube based on the reaction tube information. If it is necessary to supply the detergent to the reaction tube, the first switching valve is controlled to switch the detergent supply destination to the reaction tube cleaning nozzle. The automated analyzer according to claim 4.

9. The system further includes a reaction tube information acquisition unit that acquires reaction tube information, which includes at least cleaning status information regarding the cleaning status of the reaction tube located at a reaction tube cleaning position, which is a position for cleaning the reaction tube. The first control unit is, Based on the reaction tube information, it is determined whether or not it is necessary to supply the detergent to the reaction tube. If it is necessary to supply detergent to the reaction tube, the first switching valve is controlled to switch the detergent supply destination to the reaction tube cleaning nozzle. The automated analyzer according to claim 3.

10. The system further includes a detergent storage information acquisition unit that acquires detergent storage information regarding the storage status of the detergent in the probe washing pool, The first control unit is, If it is not necessary to supply the detergent to the reaction tube, then, based on the detergent storage information, it is determined whether or not it is necessary to supply the detergent to the probe cleaning pool. If it is necessary to supply the detergent to the probe cleaning pool, the first switching valve is controlled to switch the detergent supply destination to the probe cleaning pool. The automated analyzer according to claim 9.

11. A storage unit for storing the reaction tube information, The automatic analyzer according to any one of claims 8 to 10, further comprising: a reaction tube information recording unit that records the cleaning state information in the storage unit when the cleaning state of the reaction tube changes.

12. A diluent supply pump for supplying a diluent for diluting the detergent to the detergent supply destination, A second control unit that independently controls the detergent supply pump and the diluent supply pump, The automatic analyzer according to claim 1, further comprising the following:

13. The detergent supply pump includes a first syringe and a first plunger inserted into the first syringe and movable in the inward and outward directions. The automatic analyzer according to claim 12, wherein the diluent supply pump includes a second syringe and a second plunger inserted into the second syringe and movable in an inward and outward direction.

14. A first plunger moving mechanism for moving the first plunger, A second plunger moving mechanism for moving the aforementioned second plunger, The automatic analyzer according to claim 13, further comprising the following:

15. The automatic analyzer according to claim 12, wherein the second control unit controls the detergent supply pump and the diluent supply pump so that the concentration of the detergent differs depending on the detergent supply destination.

16. The automatic analyzer according to claim 1, further comprising a second switching valve provided between the detergent installation section, the detergent supply pump, and the first switching valve, which switches between supplying the detergent from the detergent container to the detergent supply pump and supplying the detergent from the detergent supply pump to the first switching valve.

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