Catheter for use with a clot treatment system - Patent Application 20070122997

Abstract

Disclosed herein is a catheter for use with a clot treatment system, as well as related devices and methods. The catheter can include an outer sheath, an outer sheath drive component operably coupled to the outer sheath, a guidewire sheath slidably disposed within the outer sheath, a guidewire sheath drive component operably coupled to the guidewire sheath and slidably disposed within the outer sheath drive component, and a clot treatment component. During a clot treatment procedure, the outer sheath drive component can be moved proximally and / or the guidewire sheath drive component can be moved distally to cause corresponding movement of the outer sheath and / or the guidewire sheath, respectively, to transition the catheter between a first configuration in which the clot treatment component can be positioned within the outer sheath and a second configuration in which at least a portion of the clot treatment component can extend beyond the outer sheath.

Description

[Technical Field]

[0001] (CROSS-REFERENCE TO RELATED APPLICATIONS) This application claims priority to U.S. Provisional Patent Application No. 63 / 437,885, entitled "CATHETER FOR USE WITH CLOT TREATMENT SYSTEMS," filed January 9, 2023, which is incorporated herein by reference in its entirety.

[0002] FIELD OF THE INVENTION TECHNICAL FIELD The present technology relates generally to thrombectomy catheters for use with clot treatment systems, and related devices and methods. [Background technology]

[0003] Thromboembolism is characterized by the blockage of blood vessels. Thromboembolic disorders, such as stroke, pulmonary embolism, heart attack, peripheral thrombosis, and atherosclerosis, affect many people. These diseases are major causes of morbidity and mortality.

[0004] When an artery is occluded by a clot, tissue ischemia develops. Ischemia progresses to tissue infarction if the occlusion persists. However, if blood flow is rapidly restored, infarction may not occur or may be severely limited. Thus, failure to restore blood flow may lead to limb loss, angina, myocardial infarction, stroke, and even death.

[0005] In the venous circulation, obstructive material can also cause serious harm. Blood clots can develop in the large veins of the legs and pelvis, a common condition known as deep venous thrombosis (DVT). DVT typically occurs when there is a tendency for blood stagnation (e.g., long-distance air travel, immobility, etc.) and clots (e.g., cancer, recent surgery, such as orthopedic surgery, etc.). DVT can prevent venous blood from draining from the legs, leading to swelling, ulcers, pain, and infection. DVT can also create reservoirs in which clots can collect and then travel to other parts of the body, including the heart, lungs, brain (which can cause a stroke), abdominal organs, and / or limbs.

[0006] Various thrombectomy devices exist for removing occlusive material (e.g., blood clots) and restoring blood flow within a patient. A thrombectomy device typically includes a catheter that includes a mechanical clot treatment component for engaging and removing occlusive material lodged within a blood vessel. Such thrombectomy devices are often delivered intravascularly to the occlusive material over a guidewire, which often extends through the entire length of the catheter lumen. The guidewire may be too short for some procedures, resulting in insufficient length on the guidewire to deliver the thrombectomy device to the occlusive material. Additionally, long thrombectomy devices may require excessive time for exchange over the guidewire. This can complicate the thrombectomy procedure, such as improperly removing the occlusive material or otherwise failing to restore sufficient blood flow within the patient. Summary of the Invention [Means for solving the problem]

[0007] The present technology is generally directed to thrombectomy catheters for use with clot treatment systems, as well as related devices and methods. In some of the embodiments described in detail below, the thrombectomy catheter ("catheter") can include an outer sheath, an outer sheath drive component operably coupled to the outer sheath, a guidewire sheath slidably disposed within the outer sheath, and a guidewire sheath drive component operably coupled to the guidewire sheath and slidably disposed within the outer sheath drive component. Additionally, the catheter can include a clot treatment component. The clot treatment component can be coupled to the guidewire sheath and positionable within the outer sheath. In these and other embodiments, the catheter can include at least one clot treatment drive component operably coupled to the clot treatment component. The clot treatment drive component can be positioned between the outer sheath drive component and the guidewire sheath drive component (e.g., radially therebetween, nested therebetween, etc.).

[0008] During a clot treatment procedure (e.g., removal of occlusive material), the catheter can be transitioned between a first (e.g., covered) configuration in which the clot treatment component is housed within the outer sheath and a second (e.g., deployed) configuration in which the clot treatment component is deployed from within the outer sheath by moving the outer sheath and / or guidewire sheath relative to one another. For example, to transition the catheter from the first configuration to the second configuration, a user can move the guidewire sheath drive component in a first direction (e.g., distally) relative to the outer sheath to cause corresponding movement of the guidewire sheath, thereby extending at least a portion of the guidewire sheath outward from within the outer sheath. The clot treatment component can be coupled to or positioned around a portion of the guidewire sheath such that extending this portion of the guidewire sheath outward from within the outer sheath can allow the clot treatment component to expand or deploy. Additionally or alternatively, to transition the catheter from the first configuration to the second configuration, the user can move the outer sheath drive component in a second direction (e.g., proximally) relative to the guidewire sheath, causing corresponding movement of the outer sheath, thereby retracting the outer sheath over the guidewire sheath, e.g., exposing a portion of the guidewire sheath. To transition the catheter from the second configuration to the first configuration, movement of the guidewire sheath drive component and / or the outer sheath drive component can be reversed, e.g., the user can move the guidewire sheath drive component in the second direction and / or the outer sheath drive component in the first direction.

[0009] The clot treatment component can be fully enclosed within the outer sheath in a first configuration, for example, for delivery through a blood vessel to a site of an occlusion. In a second configuration, at least a portion of the clot treatment component can be deployed from or extend beyond the outer sheath. For example, in the second configuration, the clot treatment component can be positioned to engage an occlusion during clot treatment. In some embodiments, a user can deploy, encase, and / or change at least one dimension (e.g., length, width, diameter, cross-sectional area, and the like) of the clot treatment component and / or change at least one characteristic or mechanical property (e.g., radial force, tension, compression, shape, and the like) of the clot treatment component by moving the clot treatment drive component. [Brief explanation of the drawings]

[0010] Many aspects of the present technology can be better understood with reference to the following drawings. The accompanying figures depict embodiments of the present technology and are not intended to limit its scope unless explicitly stated. The sizes of various depicted elements are not necessarily drawn to scale, and these various elements may be enlarged to improve readability. Details of components may be abstracted in the figures to exclude details such as the location of components and specific precise connections between such components when such details are not necessary for a complete understanding of how to make and use the technology. Furthermore, components may be shown as transparent in certain figures for clarity of illustration only, and this does not necessarily indicate that the components are transparent. Many of the details, dimensions, angles, and other features shown in the figures are merely illustrative of particular embodiments of the present disclosure. Thus, other embodiments can have other details, dimensions, angles, and features without departing from the present technology. Additionally, those skilled in the art will understand that further embodiments of the present technology can be practiced without some of the details described below. [Figure 1A]1A and 1B are side views of a clot treatment catheter in a first and second configuration, respectively, in accordance with an embodiment of the present technology. [Figure 1B] 1A and 1B are side views of a clot treatment catheter in a first and second configuration, respectively, in accordance with an embodiment of the present technology. [Figure 1C] FIG. 1C is a partial schematic cross-sectional view of the catheter of FIGS. 1A and 1B taken along line 1C-1C of FIG. 1A, in accordance with an embodiment of the present technology. [Figure 2A] 2A and 2B are enlarged side views of a portion of the clot treatment catheter of FIGS. 1A and 1B in first and second configurations, respectively, in accordance with an embodiment of the present technology. [Figure 2B] 2A and 2B are enlarged side views of a portion of the clot treatment catheter of FIGS. 1A and 1B in first and second configurations, respectively, in accordance with an embodiment of the present technology. [Figure 3A] 3A and 3B are side views of another clot treatment catheter in a first configuration and a second configuration, respectively, in accordance with an embodiment of the present technology. [Figure 3B] 3A and 3B are side views of another clot treatment catheter in a first configuration and a second configuration, respectively, in accordance with an embodiment of the present technology. [Figure 3C] 3C is a partial schematic cross-sectional view of the clot treatment catheter of FIGS. 3A and 3B taken along line 3C-3C of FIG. 3A in accordance with an embodiment of the present technology. [Figure 4A] 4A and 4B are side views of the clot treatment catheter of FIGS. 1A-1C in a first configuration and a second configuration, respectively, in accordance with an embodiment of the present technology. [Figure 4B] 4A and 4B are side views of the clot treatment catheter of FIGS. 1A-1C in a first configuration and a second configuration, respectively, in accordance with an embodiment of the present technology. [Figure 5] FIG. 5 is a side view of the clot treatment catheter of FIGS. 3A and 3B in a second configuration in accordance with an embodiment of the present technology. [Figure 6A]6A and 6B are cross-sectional side views of the clot treatment catheters of FIGS. 1A and 1B, respectively, in accordance with an embodiment of the present technology. [Figure 6B] 6A and 6B are cross-sectional side views of the clot treatment catheters of FIGS. 1A and 1B, respectively, in accordance with an embodiment of the present technology. [Figure 7] FIG. 7 is a side view of the clot treatment catheter of FIGS. 3A and 3B in a second configuration in accordance with an embodiment of the present technology. [Figure 8] FIG. 8 is a side view of the clot treatment catheter of FIGS. 3A and 3B in a second configuration in accordance with an embodiment of the present technology. DETAILED DESCRIPTION OF THE INVENTION

[0011] In some aspects of the present technology, the catheters can occupy a relatively short length of the guidewire, such that increased length of the guidewire is available to, for example, allow for intravascular delivery of additional clot treatment devices within a patient. This is expected to reduce at least some complications that may arise during a clot treatment and / or removal procedure, such as when an insufficient length of guidewire is available for a user to adequately address a patient's clot. Additionally, or alternatively, at least some of the catheters are expected to be easier for a user to transition between configurations, allowing a user to more easily / simplely perform multiple passes through clot material during a procedure. For example, at least some of the catheters may be configured so that the clot treatment component can be fully or at least partially re-covered after the clot treatment component is deployed. In these and other embodiments, the catheters of the present technology are expected to occupy and / or engage a shorter length of the guidewire compared to other clot treatment devices, which may allow the catheter to be more easily / simplely loaded and removed from the guidewire when performing multiple passes through clot material within a patient.

[0012] Certain details are set forth in the following description and in FIGS. 1A-8 to provide a thorough understanding of various embodiments of the present technology. In other instances, to avoid unnecessarily obscuring the description of various embodiments of the present technology, well-known structures, materials, operations, and / or systems often associated with intravascular procedures, hemofiltration, clot removal procedures, catheters, and the like, are not shown or described in detail in the following disclosure. However, one of ordinary skill in the art will recognize that the present technology may be practiced without one or more of the details described herein and / or with other structures, methods, components, and the like. Furthermore, although many of the devices and systems are described herein in the context of removing and / or treating clot material, the present technology can be used to remove and / or treat any undesirable material in addition to, or as an alternative to, clot material, such as thrombus, embolus, plaque, etc. Accordingly, the terms "clot" and "clot material," as used herein, can refer to any of the aforementioned materials within a container.

[0013] The terms used below should be interpreted in their broadest reasonable manner, even when used in conjunction with the detailed description of specific examples of embodiments of the present technology. Indeed, certain terms may even be emphasized below; however, any terms intended to be interpreted in any limiting manner are expressly and specifically defined as such in this detailed description section.

[0014] With respect to the terms "distal" and "proximal" herein, unless otherwise specified, these terms may refer to the relative position of portions of a catheter subsystem with respect to an operator and / or location within the vasculature. Also, as used herein, designations such as "rear," "forward," "superior," "inferior," etc. are not meant to limit the referenced components to a particular orientation. It is understood that such designations refer to the orientation of the referenced components as illustrated in the figures, and that the systems of the present technology may be used in any orientation suitable to the user.

[0015] 1A and 1B are side views of a clot treatment catheter ("catheter 100") in a first configuration 101a and a second configuration 101b, respectively, in accordance with an embodiment of the present technology. FIG. 1C is a partial schematic cross-sectional view of catheter 100 taken along line 1C-1C in FIG. 1A in accordance with an embodiment of the present technology. FIGs. 6A and 6B are cross-sectional views of catheter 100 in a first configuration 101a and a second configuration 101b, respectively, in accordance with an embodiment of the present technology. In FIGS. 1A, 1B, 6A, and 6B, aspects of catheter 100 are illustrated as transparent for clarity.

[0016] In some embodiments, catheter 100 includes a first or distal end portion 102a and a second or proximal end portion 102b (the various ends / end portions described herein are not visible in the plan view of FIG. 1C ). During a clot treatment procedure, catheter 100 can be advanced intravascularly to a treatment site within a blood vessel of patient P. In at least some embodiments, for example, catheter 100 is advanced through the vasculature until all or a portion of clot treatment component 150 (not shown in FIGS. 6A and 6B ) is positioned within or distal to the clot material within the blood vessel.

[0017] The catheter 100 can include one or more sheaths and / or components. In some embodiments, the catheter 100 includes an outer sheath 110, an outer sheath drive component 120, a guidewire sheath 130, a guidewire sheath drive component 140, and a clot treatment component 150 (shown schematically). With reference to Figures 1A and 6A, the outer sheath 110 can include an elongate tube or member having a first or distal end portion 112a, a second or proximal end portion 112b opposite the distal end portion 112a, and a lumen 114 ("outer sheath lumen 114") extending from the distal end portion 112a to the proximal end portion 112b. The outer sheath drive component 120 may comprise an elongated tube or member having a distal end portion 122a, a proximal end portion 122b opposite the distal end portion 122a, and a lumen 124 (the "outer sheath drive component lumen 124") extending from the distal end portion 122a to the proximal end portion 122b. At least a portion of the outer sheath drive component 120 (e.g., at least a portion of the distal end portion 122a) may be positioned within the outer sheath lumen 114 and coupled to the outer sheath 110. The proximal end portion 122b of the outer sheath drive component 120 may extend proximally from the proximal end portion 112b of the outer sheath 110 and / or may be integrated with a handle or other user interface, for example, to enable a user to grasp, manipulate, move, etc. The outer sheath drive component 120 thereby moves the outer sheath 110 relative to one or more other portions of the catheter 100 .

[0018] The guidewire sheath 130 may be positioned at least partially within the outer sheath lumen 114, for example, proximate / adjacent to the outer sheath drive component 120. The guidewire sheath 130 may comprise a tube having a first end portion or distal end or tip portion 132a ("distal tip 132a"), a second end portion or proximal end portion 132b, and a lumen 134 ("guidewire sheath lumen 134") extending from the distal tip 132a to the proximal end portion 132b. The distal tip 132a may be integral with the guidewire sheath 130 or may be a separate component coupled to the distal end of the guidewire sheath 130. The distal tip 132a of the guidewire sheath 130 may define a distal terminus 136 of the catheter 100. The guidewire sheath lumen 134 may be configured to receive a guidewire (not shown) therethrough. In at least some embodiments, for example, a guidewire can be inserted into the guidewire sheath lumen 134 via the distal tip 132a and extend completely beyond the proximal end portion 132b of the guidewire sheath 130. The guidewire sheath 130 can be relatively short in length. For example, the guidewire sheath 130 can be shorter than the entire length of the catheter 100 between the distal end portion 102a and the proximal end portion 102b. Additionally or alternatively, the proximal end 122b of the outer sheath drive component 120 can extend proximally beyond the proximal end 132b of the guidewire sheath 130 in the first configuration 101a and the second configuration 101b. In some aspects of the present technology, a relatively short guidewire sheath 130 is expected to enable an increase in the length of the guidewire available for intravascular delivery of additional clot treatment devices within a patient. This, in turn, may reduce congestion within the vessel, improve maneuverability within the vessel, and / or increase the amount of clot material that can be removed from the patient.

[0019] The guidewire sheath drive component 140 can be positioned at least partially within the outer sheath drive component lumen 124 and can be coupled to the guidewire sheath 130. The guidewire sheath drive component 140 can include an elongate shaft, tube, or member having a first or distal end portion 142a and a second or proximal end portion 142b opposite the distal end portion 142a. The distal end portion 142a of the guidewire sheath drive component 140 extends distally from the distal end portion 122a of the outer sheath drive component 120 and is coupled to the guidewire sheath 130, as shown and described in further detail with reference to FIGS. 2A and 2B . The proximal end portion 142b can extend proximally from the proximal end portion 122b of the outer sheath drive component 120 and / or can be integrated with a handle or user interface, for example, to allow a user to grasp, manipulate, move, etc. The guidewire sheath drive component 140 thereby moves the guidewire sheath 130 relative to one or more other portions of the catheter 100 .

[0020] The clot treatment component 150 can comprise one or more of the clot treatment components described in detail in U.S. Patent Nos. 8,784,434, 10,342,571, and / or 10,912,577, the entireties of which are incorporated by reference herein. In at least some embodiments, for example, the clot treatment component 150 can include one or more stents, baskets, disks, spheres, funnels, balloons, and / or tubes, each of which can be laser cut, braided, extruded, woven components, or the like. The clot treatment component 150 can be positioned within the outer sheath lumen 114, for example, between the inner surface of the outer sheath 110 and the outer surface of the guidewire sheath 130. Referring to FIG. 1B , which shows the clot treatment component 150 in a deployed or expanded configuration, the clot treatment component 150 can include a distal end portion 152 a and a proximal end portion 152 b opposite the distal end portion 152 a. The clot treatment component 150 can be coupled to the catheter 100, for example, at one or both of the end portions 152 a, 152 b and / or at one or more other suitable portions of the clot treatment component 150 between the end portions 152 a, 152 b. In at least some embodiments, for example, the distal end portion 152 a of the clot treatment component 150 can be coupled to the guidewire sheath 130 (e.g., the distal tip 132 a) and / or any other suitable sheath and / or component of the catheter 100. Additionally or alternatively, the proximal end portion 152 b of the clot treatment component 150 can be coupled to the guidewire sheath 130 and / or any other suitable sheath and / or component of the catheter 100. In embodiments in which one end (e.g., distal end portion 152a) of the clot treatment component 150 is coupled to the guidewire sheath 130 and / or another suitable sheath and / or component of the catheter 100, the other end (e.g., proximal end portion 152b) of the clot treatment component 150 can move or slide relative to the catheter 100, for example, along the outer surface of the guidewire sheath 130 and / or at least partially between the distal end portion 112a of the outer sheath 110 and the proximal end portion 138 of the distal tip 132a.In at least some embodiments, the clot treatment component 150 is not coupled to the catheter 100 (e.g., free-floating), and both the distal end portion 152 a and the proximal end portion 152 b can move or slide relative to each other and / or relative to the catheter 100 while being retained on the guidewire sheath 130, for example, via mechanical interference with the proximal end portion 138 of the distal tip 132 a and / or the distal end portion 112 a of the outer sheath 110. In these and other embodiments, the clot treatment component 150 can be configured to deploy / expand (e.g., radially deploy / expand, longitudinally deploy / expand, etc.) when the catheter 100 transitions from the first configuration 101 a ( FIG. 1A ) to the second configuration 101 b ( FIG. 1B ). The clot treatment component 150 can automatically expand, for example, in response to movement (e.g., by a user) of one or more of the sheath and / or other components of the catheter 100.

[0021] 1A, 1B, 6A, and 6B together, during a clot treatment procedure, the catheter 100 can be transitioned between a first configuration 101a (FIG. 1A) and a second configuration 101b (FIG. 1B) by moving one or more of the catheter components and / or the sheath. As shown in the embodiment illustrated in FIG. 1B, for example, the outer sheath actuation component 120 is moved proximally relative to the guidewire sheath 130, moving the outer sheath 110 proximally and / or away from the distal terminus 136. This transitions the catheter 100 from the first configuration 101a to and / or at least partially toward the second configuration 101b. As the outer sheath 110 moves proximally, the clot treatment component 150 is progressively exposed in a distal-to-proximal motion that allows the clot treatment component 150 to deploy / expand from and / or at least partially to a first (e.g., delivery) state ( FIG. 1A ) to a second (e.g., deployed) state ( FIG. 1B ). In the embodiment illustrated in FIG. 1A , for example, the clot treatment component 150 is positioned entirely within the outer sheath lumen 114 between the inner surface of the outer sheath 110 and the outer surface of the guidewire sheath 130, such that the outer sheath 110 limits the expansion (e.g., radial expansion, longitudinal expansion, etc.) of the clot treatment component 150. Thus, by moving the outer sheath 110 proximally, the constraint around the clot treatment component 150 is removed, allowing the clot treatment component to expand (e.g., automatically expand) from the first state ( FIG. 1A ) to and / or at least partially toward the second state ( FIG. 1B ). The clot treatment component 150 may be configured to expand automatically due to material properties such as memory (e.g., shape memory), mechanically in response to the application of tension or compression forces, via a balloon, and / or in another suitable configuration. With the clot treatment component 150 in the second state and / or the catheter 100 in the second configuration 101 b, the catheter 100 can be used to treat / remove clot material within a patient.

[0022] The catheter 100 can be returned from the second configuration 101b to the first configuration 101a by moving the outer sheath 110 distally and / or toward the distal terminus 136, e.g., by moving the outer sheath drive component 120 distally. The clot treatment component 150 can be configured to return to the first state (FIG. 1A) as the catheter 100 transitions from the second configuration 101b toward the first configuration 101a. In at least some embodiments, for example, the proximal end portion 152b of the clot treatment component 150 can be radially beveled or tapered such that as the outer sheath 110 is moved distally, the proximal end portion 152b can be received within the outer sheath lumen 114, and continued distal movement of the outer sheath 110 can fold, encapsulate, and / or otherwise cover the clot treatment component 150 (e.g., within the outer sheath 110). Additionally or alternatively, the clot treatment component 150 can be covered by applying a tensile or compressive force to the clot treatment component 150, such as by moving the guidewire sheath 130 relative to the outer sheath 110, when the clot treatment component 150 is coupled to one or both of these sheaths 110, 130.

[0023] Additionally or alternatively, the catheter 100 can be transitioned between the first configuration 101 a and the second configuration 101 b by moving the guidewire sheath 130 relative to the outer sheath 110. In at least some embodiments, for example, the guidewire sheath drive component 140 can be moved distally relative to the outer sheath 110 to move the guidewire sheath 130 distally and / or outward from within the distal end portion 112 a of the outer sheath 110, thereby transitioning the catheter 100 from the first configuration 101 a to the second configuration 101 b and / or at least partially toward the second configuration 101 b. As the guidewire sheath 130 is moved distally, the clot treatment component 150 can be removed from within the outer sheath lumen 114 and expanded / deployed, as described above. The catheter 100 can also be transitioned from the second configuration 101b to the first configuration 101a by proximally moving the guidewire sheath driving component 140 and thereby proximally moving the guidewire sheath 130, thereby repositioning the clot treatment component 150 within the outer sheath lumen 114, as described above. In these and other embodiments, the catheter 100 can be transitioned between the first configuration 101a and the second configuration 101b by moving the outer sheath driving component 120 and the guidewire sheath driving component 140 in combination, e.g., sequentially and / or simultaneously.

[0024] 2A and 2B are enlarged side views of a portion of the catheter 100 of FIGS. 1A and 1B in a first configuration 101a and a second configuration 101b, respectively, in accordance with an embodiment of the present technology. In FIGS. 2A and 2B, aspects of the catheter 100 are illustrated as transparent for clarity. The guidewire sheath 130 may include a distal segment 231a, a proximal segment 231b opposite the distal segment 231a, and a third segment 233 (which may be referred to as an “intermediate segment,” “inner segment,” “transition segment,” “bridge segment,” etc.) extending between the distal segment 231a and the proximal segment 231b. The distal segment 231a may be generally or substantially aligned / coincident with the longitudinal axis L of the catheter 100 such that the distal segment 231a is generally or substantially concentric with the catheter 100 and / or centered within the outer sheath lumen 114. The proximal segment 231b may be offset relative to the axis of the distal segment 231a, and the third segment 233 may be an angled intermediate segment that provides a sufficiently smooth transition between the distal segment 231a and the proximal segment 231b for tracking along a guidewire (not shown). The clot treatment component 150 (FIGS. 1A and 1B) may be coupled to the distal segment 231a such that the clot treatment component 150 may be centered within the outer sheath lumen 114. In some aspects of the present technology, centering the clot treatment component 150 within the outer sheath lumen 114 is expected to improve the operator's ability to repeatedly and / or consistently unsheath and resheath (e.g., withdraw from or return into the outer sheath 110) the clot treatment component 150 during a clot treatment procedure, as described in detail above with reference to FIGS. 1A and 1B.

[0025] The proximal segment 231b can be generally or substantially parallel to the longitudinal axis L. In at least some embodiments, for example, the proximal segment 231b is not concentric / collinear with the longitudinal axis L and / or the distal segment 231a, as shown in FIGS. 2A and 2B . The outer sheath drive component 120 can be generally or substantially parallel to the proximal segment 231b and / or can be on the opposite side of the longitudinal axis L from the proximal segment 231b. In the embodiment illustrated in FIGS. 2A and 2B , the outer sheath drive component 120 and the guidewire sheath 130 are shown spaced apart for clarity of illustration, although it will be understood that in practice the outer sheath drive component 120 may or may not contact the guidewire sheath 130. The outer sheath drive component 120 can be sized such that a region 221 of the outer sheath drive component 120 maintains overlapping alignment with at least a portion of the guidewire sheath lumen 134. Thus, the outer sheath drive component 120 may be at least partially coextensive with, abutting, and / or otherwise positioned alongside the guidewire sheath lumen 134 when the catheter 100 is in the first configuration 101 a and the second configuration 101 b. In some embodiments, for example, region 221 may be coextensive with and / or abutting at least a portion of the proximal segment 231 b when the catheter 100 is in the first configuration 101 a and the second configuration 101 b ( FIGS. 1A and 1B , respectively). In some aspects of the present technology, the coextensive and / or abutting alignment between the outer sheath drive component 120 and the guidewire sheath 130 is expected to improve a user's ability to repeatedly and / or consistently withdraw and recoat the clot treatment component 150 during a clot treatment procedure while also maintaining an open lumen (e.g., the guidewire sheath lumen 134) through the catheter 100.For example, a coextensive and / or abutting relationship between the proximal segment 231b of the guidewire sheath 130 and the region 221 of the outer sheath drive component 120 in the second configuration 101b can maintain the guidewire sheath 130 and the outer sheath drive component 120 in a slidable relationship relative to one another, allowing the guidewire sheath 130 to move proximally to return the catheter 100 to the first configuration 101a. The relatively short length of the guidewire sheath 130 is expected to allow a user to reload the guidewire and / or insert other devices along the guidewire during a coagulation treatment procedure. In other embodiments, the region 221 of the outer sheath drive component 120 may not be in overlapping alignment with at least a portion of the guidewire sheath lumen 134 when the catheter 100 is in the first configuration 101a and the second configuration 101b, and still maintain the aforementioned advantages.

[0026] Intermediate segment 233 may be angled or tilted relative to longitudinal axis L, as described above. For example, intermediate segment 233 may be angled radially inward, e.g., from proximal segment 231 b toward distal segment 231 a and / or toward guidewire sheath driving component 140 toward longitudinal axis L. Intermediate segment 233 may connect distal segment 231 a and proximal segment 231 b such that guidewire sheath lumen 134 and / or a guidewire (not shown) may extend completely through guidewire sheath 130, as described above. Additionally or alternatively, guidewire sheath driving component 140 may be operably coupled to guidewire sheath 130 at or near intermediate segment 233.

[0027] 3A and 3B are side views of another clot treatment and / or clot removal catheter 300 ("catheter 300") in a first configuration 301a and a second configuration 301b, respectively, in accordance with an embodiment of the present technology. In FIGS. 3A and 3B, aspects of the catheter 300 are illustrated as transparent for clarity. FIG. 3C is a partial schematic cross-sectional view of the catheter 300 taken along line 3C-3C in FIG. 3A. The catheter 300 can include several features that are generally similar or identical in structure and / or function to aspects of the catheter 100 of FIGS. 1A-2B, and like reference numerals (e.g., outer sheath 310 versus outer sheath 110 of FIGS. 1A-2B) indicate generally similar or identical features. Additionally, in the illustrated embodiment, the catheter 300 includes a clot treatment drive component 360. The coagulation treatment drive component 360 can be positioned (e.g., radially, telescopically, etc.) between the outer sheath drive component 320 and the guidewire sheath drive component 340, such that each of the outer sheath drive component 320, the guidewire sheath drive component 340, and the coagulation treatment drive component 360 can be moved independently in the proximal and / or distal directions. In the illustrated embodiment, for example, the guidewire sheath drive component 340 is slidably disposed within the coagulation treatment drive component lumen 364 (FIG. 3B), and the coagulation treatment drive component 360 is slidably disposed within the outer sheath drive component lumen 324.

[0028] The clot treatment drive component 360 may comprise an elongated tube or member having a distal end portion 362 and a lumen 364 ("clot treatment drive component lumen 364"). The clot treatment drive component 360 may be operably coupled to the clot treatment component 350 (shown schematically in FIGS. 3A and 3B). In at least some embodiments, for example, the distal end portion 362 of the clot treatment drive component 360 may be coupled to the proximal end portion 352b of the clot treatment component 350, as shown in FIG. 3B. In these and other embodiments, any other suitable portion or end of the clot treatment drive component 360 may be coupled to any other suitable portion or end of the clot treatment component 350. Additionally or alternatively, any other suitable portion or end (e.g., distal end portion 352a) of the clot treatment component 350 may be coupled to the proximal end portion 338 of the guidewire sheath 330 and / or the distal tip 332a of the guidewire sheath 330.

[0029] During a clot treatment procedure, the outer sheath driving component 320 and / or the guidewire sheath driving component 340 can be moved to transition the catheter 300 between a first configuration 301 a and a second configuration 301 b, as described in detail above with reference to FIGS. 1A-2B. Additionally, the clot treatment driving component 360 and / or the guidewire sheath driving component 340 can be moved to transition the clot treatment component 350 between a first state ( FIG. 3A ) and a second state ( FIG. 3B ). In at least some embodiments, for example, the clot treatment driving component 360 can be moved distally to expand / deploy the clot treatment component 350 from a first (e.g., delivery) state to a second (e.g., deployed) state and / or at least partially toward the second (e.g., deployed) state. In other embodiments, the clot treatment drive component 360 can be moved proximally to expand / deploy the clot treatment component 350 from the first state to the second state and / or at least partially toward the second state. Additionally or alternatively, the clot treatment drive component 360 can be moved distally to move the clot treatment component 350 from the second state to the first state and / or at least partially back toward the first state, e.g., to position / cover the clot treatment component 350 within the outer sheath lumen 314, as shown in FIG. 3A . In other embodiments, the clot treatment drive component 360 can be moved proximally to move the clot treatment component 350 from the second state to the first state and / or at least partially back toward the first state. In these and other embodiments, the clot treatment component 350 can automatically transition between the first state and the second state, as described in detail above with respect to FIGS. 1A and 1B . In at least some embodiments, for example, the clot treatment component 350 can be biased toward one state (e.g., a second state), and the clot treatment drive component 360 and / or the guidewire sheath drive component 340 can be moved to control the degree and / or rate at which the clot treatment component 350 transitions toward the biased state.In these and other embodiments, the clot treatment driving component 360 and / or the guidewire sheath driving component 340 can be moved to adjust (e.g., increase and / or decrease) one or more dimensions (e.g., length, width, diameter, cross-sectional area, etc.) and / or to adjust one or more properties / mechanical properties (e.g., radial force, tension, compression, shape, etc.) of the clot treatment component 350. For example, as described above, moving the clot treatment driving component 360 distally to expand / deploy the clot treatment component 350 may decrease the length of the clot treatment component 350 and / or increase the cross-sectional area of ​​the clot treatment component 350.

[0030] Although the catheter 300 includes one coagulation treatment drive component 360 in the embodiment illustrated in Figures 3A-3C, in other embodiments, the catheter 300 can include more coagulation treatment drive components, such as at least two, three, four, five, or any other suitable number of coagulation treatment drive components. Each additional coagulation treatment drive component can be positioned between (e.g., radially therebetween, nested therebetween, etc.) the outer sheath drive component 320 and the guidewire sheath drive component 340, at least generally similar to the position of the coagulation treatment drive component 360. For example, a second coagulation treatment drive component (not shown in Figures 3A-3C) can be slidably disposed within the coagulation treatment drive component lumen 364 between the inner surface of the coagulation treatment drive component 360 and the outer surface of the guidewire sheath drive component 340. Each additional clot treatment drive component can be operably coupled to a respective portion or end of the clot treatment component 350, such that each additional clot treatment drive component can increase the user's ability to adjust / control the clot treatment component 350. In at least some embodiments, for example, each additional clot treatment drive component can be configured to adjust at least one dimension of the clot treatment component 350.

[0031] 4A and 4B are side views of a clot treatment catheter 100 in a first configuration 101a and a second configuration 101b, respectively, in accordance with an embodiment of the present technology. In FIGS. 4A and 4B, aspects of the catheter 100 are illustrated as transparent for clarity. In the illustrated embodiment, the catheter 100 includes a clot treatment component 450 having a plurality of struts 454. Each of the struts 454 can extend at least partially between a distal end portion 452a and a proximal end portion 452b of the clot treatment component 450. In the illustrated embodiment, the proximal end portion 452b is coupled to (e.g., configured to move with) the guidewire sheath 130, and the distal end portion 452a is configured to move / slide along the guidewire sheath 130. When the catheter 100 is in the second configuration 101b, the clot treatment component 450 can expand / deploy radially outward from the guidewire sheath 130. In some embodiments, for example, the struts 454 can be shape-memory struts and can automatically expand / deploy in response to movement of the guidewire sheath 130 and / or outer sheath 110. The clot treatment component 450 can further include an apex or radially extending portion 456 that defines the maximum outer dimension (e.g., width, radius, etc.) of the clot treatment component 405. When expanded / deployed, the clot treatment component 450 can be used to remove clot material from within a patient. Further details regarding clot treatment components can be found in U.S. Patent No. 8,784,434, previously incorporated by reference herein in its entirety. While in the embodiment shown in FIGS. 4A and 4B , the catheter 100 carries a single clot treatment component 450, in other embodiments, the catheter 100 can carry multiple clot treatment components.

[0032] FIG. 5 is a side view of a clot treatment catheter 300 in a second configuration 301b in accordance with an embodiment of the present technology. In FIG. 5, aspects of the catheter 300 are illustrated as transparent for clarity. In the illustrated embodiment, the catheter 300 includes a clot treatment component 550 including a coring element 551. The coring element 551 includes a cylindrical fenestrated structure defined by a plurality of struts 554. Each of the struts 554 may extend at least partially between a distal end portion 552a and a proximal end portion 552b of the coring element 551. The coring element 551 may include a leading edge 558 at or near the proximal end portion 552b and is configured to core or otherwise remove clot material from within a patient. For example, the coring element 551 can be extended distally from the clot material and retracted proximally such that the leading edge 558 engages the clot material, thereby capturing and / or otherwise removing at least a portion of the clot material. In some embodiments, the clot treatment component 550 further includes an expandable bag or cylindrical portion coupled to the distal portion 552a of the coring element 551 and extending distally therefrom. The expandable bag can be a braided and / or mesh structure (e.g., a braided filament mesh structure) and can be configured to capture and retain the clot material after it has been cored by the coring element 551. In some embodiments, the distal portion of the expandable bag can be coupled to the distal tip 332a of the guidewire sheath 330 (FIGS. 3A and 3B) such that movement of the guidewire sheath 330 relative to the coring element 551 can lengthen / shorten the expandable bag. Further details regarding the clot treatment component 550 can be found in US Pat. No. 10,342,571 and / or US Pat. No. 10,912,577, both of which have been previously incorporated by reference herein in their entireties.

[0033] In the illustrated embodiment, the proximal end portion 552b of the coring element 551 is coupled to the coagulation treatment driving component 360. Specifically, the catheter 300 includes a first coupling component 570a configured to couple the proximal end portion 552b of the coring element 551 to the distal end portion 362 of the coagulation treatment driving component 360. Continuing with reference to the illustrated embodiment, the catheter 300 may include a second coupling component 570b configured to couple the coring element 551 to the guidewire sheath driving component 340 and / or the guidewire sheath 330. In other embodiments, the catheter 300 may include another coagulation treatment driving component (not shown in FIG. 5 ) coupled to the coring element 551 via the second coupling component 570b. In embodiments in which first and second coupling components 570a, 570b are both coupled to coring element 551, the components / sheaths associated with first and second coupling components 570a, 570b can be moved relative to one another to manipulate coring element 551. For example, the distance between first and second coupling components 570a, 570b can be decreased (e.g., by distally advancing coagulation therapy driving component 360 and / or proximally retracting guidewire sheath driving component 340 and / or guidewire sheath 330) to cause coring element 551 to shorten longitudinally and / or expand radially outward from guidewire sheath 330. As another example, the distance between the first coupling component 570a and the second coupling component 570b can be increased (e.g., by retracting the coagulation treatment driving component 360 proximally and / or advancing the guidewire sheath driving component 340 and / or the guidewire sheath 330 distally) to cause the coring element 551 to lengthen longitudinally and / or compress radially inward toward the guidewire sheath 330.In at least some embodiments, in addition to or in lieu of moving one or more of the other sheaths / components of the catheter 300, at least a portion of the clot treatment component 550 (e.g., the expandable bag described above) can be coupled to the distal tip 332a of the guidewire sheath 330 (FIGS. 3A and 3B) such that (i) moving the guidewire sheath 330 distally can lengthen the clot treatment component 550 and / or compress the clot treatment component 550 radially inward toward the guidewire sheath 330, and (ii) moving the guidewire sheath 330 proximally can shorten the clot treatment component 550 longitudinally and / or expand the clot treatment component 550 radially outward away from the guidewire sheath 330.

[0034] FIG. 7 is a side view of a clot treatment catheter 300 in a second configuration 301b in accordance with an embodiment of the present technology. In FIG. 7, aspects of the catheter 300 are illustrated as transparent for clarity. In the illustrated embodiment, the catheter 300 includes the coring element 551 described above with reference to FIG. 5. However, in the embodiment illustrated in FIG. 7, the second coupling component 570b is not coupled to the guidewire sheath driving component 340. Instead, the guidewire sheath driving component 340 is coupled to a drive cuff 772 (e.g., a stop member) positioned about the guidewire sheath 330 distal to the second coupling component 570b. The guidewire sheath driving component 340 may be slidably disposed through the second coupling component 570b such that the drive cuff 772 and / or the second coupling component 570b can move relative to one another. This relative movement between drive cuff 772 and second coupling component 570b can be used to change the configuration of coring element 551 and / or coagulation treatment component 550. For example, drive cuff 772 can be moved proximally (e.g., by proximally retracting guidewire sheath drive component 340 and / or guidewire sheath 330) to contact second coupling component 570b and move second coupling component 570b proximally. This, in turn, can decrease the distance between first coupling component 570a and second coupling component 570b, thereby causing coring element 551 to shorten longitudinally and / or expand radially outward from guidewire sheath 330. In some embodiments, the guidewire sheath drive component 340 can be biased proximally, causing the drive cuff 772 to be biased proximally into engagement with the second coupling component 570b and causing the coring element 551 to shorten and / or expand radially outward from the guidewire sheath 330.

[0035] Figure 8 is a side view of a clot treatment catheter 300 in a second configuration 301b, in accordance with an embodiment of the present technology. In Figure 8, aspects of the catheter 300 are illustrated as transparent for clarity. The catheter 300 illustrated in Figure 8 may include at least some features that are at least generally similar or identical in structure and / or function to the catheter 300 described above with reference to Figure 7. However, in the embodiment illustrated in Figure 8, the drive cuff 772 is positioned about the guidewire sheath 330 proximal to the second coupling component 570b. Thus, drive cuff 772 can be moved distally (e.g., by distally advancing guidewire sheath drive component 340 and / or coagulation treatment drive component 360) to contact second coupling component 570b and increase the distance between first coupling component 570a and second coupling component 570b, causing coring element 551 to lengthen longitudinally and / or compress radially inward toward guidewire sheath 330. In some embodiments, guidewire sheath drive component 340 can be biased distally such that drive cuff 772 is biased distally into engagement with second coupling component 570b and causes coring element 551 to lengthen and / or contract radially inward toward guidewire sheath 330.

[0036] Thus, in some aspects of the present technology, a catheter can include an outer sheath, an outer sheath drive component operably coupled to the outer sheath, a guidewire sheath slidably disposed within the outer sheath, and a guidewire sheath drive component operably coupled to the guidewire sheath and slidably disposed within the outer sheath drive component. The outer sheath drive component can be moved proximally and / or distally to cause corresponding movement of the outer sheath. The guidewire sheath drive component can be moved proximally and / or distally to cause corresponding proximal and / or distal movement of the guidewire sheath. Movement of the outer sheath and / or guidewire sheath can transition the catheter between a first configuration and a second configuration. In some embodiments, the catheter includes a clot treatment component carried within the outer sheath, and during a procedure, the clot treatment component can be deployed from and / or repositioned within the outer sheath by moving one or both of the outer sheath drive component and the guidewire sheath drive component. For example, the clot treatment component can be carried within the outer sheath when the catheter is in the first configuration, and the clot treatment component can be deployed from the outer sheath when the catheter is in the second configuration. In these and other embodiments, the catheter can include at least one clot treatment drive component operably coupled to the clot treatment component. The clot treatment drive component can be positioned between the outer sheath drive component and the guidewire sheath drive component (e.g., radially therebetween, nested therebetween, etc.). During a procedure, the clot treatment drive component can be moved proximally and / or distally to deploy, cover, and / or change at least one dimension (e.g., length, width, diameter, cross-sectional area, and the like) of the clot treatment component. [Example]

[0037] Some aspects of the present technology are described in the following examples: 1. An intravascular catheter for treating clot material from within a blood vessel of a human patient, comprising: an outer sheath having an outer sheath lumen; an outer sheath drive component having an outer sheath drive component lumen, the outer sheath drive component being operably coupled to the outer sheath; a guidewire sheath including a guidewire sheath lumen configured to receive a guidewire, at least a portion of the guidewire sheath being slidably disposed within the outer sheath lumen; a guidewire sheath drive component slidably disposed within the outer sheath drive component lumen, the guidewire sheath drive component operably coupled to the guidewire sheath; and An intravascular catheter comprising: a clot treatment component coupled to a guidewire sheath, the clot treatment component configured to transition between (i) a first configuration in which the clot treatment component is positioned within the outer sheath lumen, and (ii) a second configuration in which at least a portion of the clot treatment component is exposed from the outer sheath lumen, in response to movement of the outer sheath drive component, the guidewire sheath drive component, or both the outer sheath drive component and the guidewire sheath drive component. 2. The catheter of Example 1, further comprising a coagulation treatment drive component slidably disposed within the outer sheath drive component lumen and operably coupled to the coagulation treatment component, wherein the coagulation treatment component is configured to transition between a first configuration and a second configuration in response to movement of the coagulation treatment drive component, the outer sheath drive component, the guidewire sheath drive component, or any two or more of the outer sheath drive component, the guidewire sheath drive component, and the coagulation treatment drive component. 3. The catheter of Example 1 or Example 2, wherein the outer sheath drive component includes a region configured to overlap a portion of the guidewire sheath when the clot treatment component is in the first configuration and the second configuration. 4. The catheter of Example 3, wherein the guidewire sheath includes a proximal segment and a distal segment, at least a portion of the proximal segment configured to abut a portion of the outer sheath drive component, and the distal segment is centered within the outer sheath lumen. 5. The catheter of Example 4, wherein at least a portion of the clot treatment component is coupled to a distal segment of the guidewire sheath. 6. The catheter of Example 5, wherein the distal segment of the guidewire sheath comprises the distal tip of the catheter, and at least a portion of the clot treatment component is coupled to the distal tip. 7. The catheter of any of Examples 4-6, wherein at least a portion of the clot treatment component is slidably disposed on the distal segment. 8. The catheter of any of Examples 4 to 7, wherein the guidewire sheath further includes an intermediate segment extending between the distal segment and the proximal segment, the intermediate segment sloping radially inward from the proximal segment to the distal segment. 9. The catheter of Example 1, wherein the guidewire sheath includes a distal segment centered within the outer sheath lumen, and wherein at least a portion of the clot treatment component is coupled to the distal segment of the guidewire sheath. 10. The catheter of Example 9, wherein the distal segment of the guidewire sheath comprises the distal tip of the catheter, and at least a portion of the clot treatment component is coupled to the distal tip. 11. The catheter of Example 9 or Example 10, wherein at least a portion of the clot treatment component is slidably disposed on the distal segment of the guidewire sheath. 12. The catheter of any of Examples 9-11, wherein the guidewire sheath further comprises a proximal segment positioned radially outward from the distal segment of the guidewire sheath. 13. The catheter of example 12, wherein the proximal segment is not centered within the outer sheath lumen. 14. The catheter of Example 12 or Example 13, wherein the guidewire sheath further includes an intermediate segment extending between the distal segment and the proximal segment, the intermediate segment sloping radially inward from the proximal segment to the distal segment. 15. A method for the intravascular treatment of clot material from within a blood vessel of a human patient, the method comprising: advancing the catheter distally through the blood vessel; transitioning the catheter from (i) a first configuration in which a clot treatment component of the catheter is positioned within an outer sheath lumen of an outer sheath of the catheter, and (ii) a second configuration in which at least a portion of the clot treatment component is exposed from the outer sheath lumen; The catheter includes: (a) an outer sheath drive component including an outer sheath drive component lumen and coupled to the outer sheath; and (b) an elongate member operably coupled to the coagulation treatment component and slidably disposed within the outer sheath drive component lumen; Translocating the catheter moving the outer sheath actuation component in a first direction relative to the clot treatment component to cause the outer sheath to uncover at least a portion of the clot treatment component; and / or moving the elongate member in a second direction relative to the outer sheath to extend at least a portion of the clot treatment component beyond the outer sheath lumen. 16. The method of example 15, wherein the second direction is opposite to the first direction. 17. The method of example 15, further comprising expanding the clot treatment component when the catheter is in the second configuration. 18. The method of example 17, wherein expanding the clot treatment component comprises transitioning the catheter to a second configuration to allow the clot treatment component to expand. 19. The method of Example 17, wherein expanding the clot treatment component comprises moving a clot treatment drive component operably coupled to the clot treatment component relative to a guidewire sheath positioned within the catheter and adjacent to the outer sheath drive component. 20. The method of example 17, wherein expanding the clot treatment component comprises moving a drive cuff of the catheter to cause expansion of the clot treatment component. 21. The method of example 20, wherein moving the drive cuff comprises moving the drive cuff in a first direction relative to the clot treatment component to drive expansion of the clot treatment component. 22. The method of example 20, wherein moving the drive cuff comprises moving the drive cuff in a first direction relative to the clot treatment component to allow the clot treatment component to expand. 23. The method of any of Examples 15-22, wherein the elongate member includes a guidewire sheath driving component, and moving the elongate member includes moving the guidewire sheath driving component in a second direction relative to the outer sheath to extend at least a portion of the coagulation treatment component beyond the outer sheath lumen. 24. The method of Example 23, wherein moving the guidewire sheath driving component comprises causing movement of a guidewire sheath operably coupled to the guidewire sheath driving component, and wherein the clot treatment component is operably coupled to the guidewire sheath such that causing movement of the guidewire sheath comprises extending at least a portion of the clot treatment component beyond the outer sheath lumen. 25. A catheter for treating a human patient, comprising: an outer sheath having an outer sheath lumen; an outer sheath drive component having an outer sheath drive component lumen, the outer sheath drive component being slidably disposed within the outer sheath lumen and operably coupled to the outer sheath; a guidewire sheath including a guidewire sheath lumen configured to receive a guidewire, at least a portion of the guidewire sheath being slidably disposed within the outer sheath and laterally adjacent the outer sheath drive component; a guidewire sheath drive component slidably disposed within the outer sheath drive component, the guidewire sheath drive component operably coupled to the guidewire sheath; a coagulation treatment component coupled to the guidewire sheath; a coagulation treatment drive component slidably disposed within the outer sheath drive component lumen and operably coupled to the coagulation treatment component; the catheter is configured to transition between (i) a first configuration in which the clot treatment component is positioned within the outer sheath lumen and (ii) a second configuration in which at least a portion of the clot treatment component is exposed from the outer sheath lumen in response to movement in response to at least one of (a) a first movement of the outer sheath drive component in a first direction relative to the guidewire sheath and (b) a second movement of the guidewire sheath drive component in a second direction relative to the outer sheath; A catheter, wherein the clot treatment drive component is configured to transition the clot treatment component between (i) a first state in which the clot treatment component has a first dimension, and (ii) a second state in which the clot treatment component has a second dimension that is larger or smaller than the first dimension. 26. In a first state, the clot treating component has a first mechanical property; The catheter of Example 25, wherein in the second state, the clot treating component has a second mechanical property. 27. the first mechanical property comprises at least one of a first radial force, a first tensile force, a first compressive force, and / or a first shape; The catheter of Example 26, wherein the second mechanical property includes at least one of a second radial force, a second tensile force, a second compressive force, and / or a second shape. 28. The catheter of any of Examples 25-27, wherein the clot treatment component comprises a mechanical thrombectomy component extending radially outward from the guidewire sheath. 29. The catheter of any of Examples 25-27, wherein the clot treatment component includes a coring element having a proximally facing leading edge. 30. The catheter of any of Examples 25-29, wherein the clot treatment drive component is a first clot treatment drive component operably coupled to a first portion of the clot treatment component, and the catheter further comprises a second clot treatment drive component slidably coupled to a second portion of the clot treatment component. 31. The catheter of Example 30, wherein the first coagulation treatment drive component includes a first coagulation treatment drive component lumen, and the second coagulation treatment drive component is slidably disposed within the first coagulation treatment drive component lumen. 32. The catheter of any of Examples 25-31, wherein the second direction is opposite to the first direction.

[0038] The above detailed description of embodiments of the present technology is not intended to be exhaustive or to limit the present technology to the precise form disclosed above. Specific embodiments of the technology, and examples of the technology, are described above for illustrative purposes; however, those skilled in the art will recognize that various equivalent modifications are possible within the scope of the technology. For example, while steps are presented in a given order, alternative embodiments may perform steps in a different order. Various embodiments described herein may also be combined to provide further embodiments.

[0039] From the foregoing, it will be understood that, although specific embodiments of the present technology have been described herein for illustrative purposes, well-known structures and functions have not been shown or described in detail to avoid unnecessarily obscuring the description of the embodiments of the present technology. Where permitted by context, singular or plural terms may also include the plural or singular terms, respectively.

[0040] Furthermore, unless the word "or" is expressly limited in reference to a list of two or more items to mean only a single item exclusively from the other items, the use of "or" in such a list should be interpreted as including (a) any single item in the list, (b) all of the items in the list, or (c) any combination of the items in the list. Additionally, the term "comprising" is used throughout to mean the inclusion of at least the recited features, but not the exclusion of any more of the same features and / or other features of additional types. While specific embodiments have been described herein for illustrative purposes, it will also be understood that various modifications can be made without departing from the present technology. Furthermore, while advantages associated with some embodiments of the present technology have been described in the context of these embodiments, other embodiments may also exhibit such advantages, and not all embodiments necessarily exhibit such advantages to fall within the scope of the present technology. Thus, the present disclosure and related technology may encompass other embodiments not explicitly shown or described herein.

Claims

1. 1. An intravascular catheter for treating clot material from within a blood vessel of a human patient, comprising: an outer sheath having an outer sheath lumen; an outer sheath drive component having an outer sheath drive component lumen, the outer sheath drive component being operably coupled to the outer sheath; and a guidewire sheath including a guidewire sheath lumen configured to receive a guidewire, at least a portion of the guidewire sheath being slidably disposed within the outer sheath lumen; a guidewire sheath drive component slidably disposed within the outer sheath drive component lumen, the guidewire sheath drive component operably coupled to the guidewire sheath; and a clot treatment component coupled to the guidewire sheath, the clot treatment component configured to transition between (i) a first configuration in which the clot treatment component is positioned within the outer sheath lumen, and (ii) a second configuration in which at least a portion of the clot treatment component is exposed from the outer sheath lumen, in response to movement of the outer sheath drive component, the guidewire sheath drive component, or both the outer sheath drive component and the guidewire sheath drive component.

2. 2. The catheter of claim 1, further comprising a coagulation treatment drive component slidably disposed within the outer sheath drive component lumen and operably coupled to the coagulation treatment component, wherein the coagulation treatment component is configured to transition between the first configuration and the second configuration in response to movement of the coagulation treatment drive component, the outer sheath drive component, the guidewire sheath drive component, or any two or more of the outer sheath drive component, the guidewire sheath drive component, and the coagulation treatment drive component.

3. 10. The catheter of claim 1, wherein the outer sheath drive component includes a region configured to overlap a portion of the guidewire sheath when the clot treatment component is in the first configuration and the second configuration.

4. 4. The catheter of claim 3, wherein the guidewire sheath includes a proximal segment and a distal segment, at least a portion of the proximal segment configured to abut the portion of the outer sheath drive component, and the distal segment is centered within the outer sheath lumen.

5. The catheter of claim 4 , wherein at least a portion of the clot treatment component is coupled to the distal segment of the guidewire sheath.

6. The catheter of claim 5 , wherein the distal segment of the guidewire sheath comprises a distal tip of the catheter, and at least the portion of the clot treatment component is coupled to the distal tip.

7. The catheter of claim 4 , wherein at least a portion of the clot treatment component is slidably disposed on the distal segment.

8. 5. The catheter of claim 4, wherein the guidewire sheath further includes an intermediate segment extending between the distal segment and the proximal segment, the intermediate segment sloping radially inward from the proximal segment toward the distal segment.

9. The catheter of claim 1 , wherein the guidewire sheath includes a distal segment centered within the outer sheath lumen, and at least a portion of the clot treatment component is coupled to the distal segment of the guidewire sheath.

10. The catheter of claim 9 , wherein the distal segment of the guidewire sheath comprises a distal tip of the catheter, and at least the portion of the clot treatment component is coupled to the distal tip.

11. The catheter of claim 9 , wherein at least a portion of the clot treatment component is slidably disposed on the distal segment of the guidewire sheath.

12. The catheter of claim 9 , wherein the guidewire sheath further comprises a proximal segment positioned radially outward from the distal segment of the guidewire sheath.

13. The catheter of claim 12 , wherein the proximal segment is not centered within the outer sheath lumen.

14. 13. The catheter of claim 12, wherein the guidewire sheath further includes an intermediate segment extending between the distal segment and the proximal segment, the intermediate segment sloping radially inward from the proximal segment toward the distal segment.

15. 1. A method for the endovascular treatment of clot material from within a blood vessel of a human patient, said method comprising: advancing a catheter distally through the blood vessel; transitioning the catheter from (i) a first configuration in which a clot treatment component of the catheter is positioned within an outer sheath lumen of an outer sheath of the catheter, and (ii) a second configuration in which at least a portion of the clot treatment component is exposed from the outer sheath lumen; the catheter includes: (a) an outer sheath drive component including an outer sheath drive component lumen and coupled to the outer sheath; and (b) an elongate member operably coupled to the clot treatment component and slidably disposed within the outer sheath drive component lumen; Translating the catheter moving the outer sheath actuation component in a first direction relative to the clot treatment component to cause the outer sheath to uncover at least the portion of the clot treatment component; and / or moving the elongate member in a second direction relative to the outer sheath to cause at least the portion of the clot treating component to extend beyond the outer sheath lumen.

16. The method of claim 15 , wherein the second direction is opposite to the first direction.

17. The method of claim 15, further comprising expanding the clot treatment component when the catheter is in the second configuration.

18. 18. The method of claim 17, wherein expanding the clot treatment component comprises transitioning the catheter to the second configuration to allow the clot treatment component to expand.

19. 18. The method of claim 17, wherein expanding the clot treatment component comprises moving a clot treatment drive component operably coupled to the clot treatment component relative to a guidewire sheath positioned within the catheter and adjacent to the outer sheath drive component.

20. 18. The method of claim 17, wherein expanding the clot treatment component comprises moving a drive cuff of the catheter to cause the expansion of the clot treatment component.

21. 21. The method of claim 20, wherein moving the drive cuff comprises moving the drive cuff in the first direction relative to the clot treatment component to drive the expansion of the clot treatment component.

22. 21. The method of claim 20, wherein moving the drive cuff comprises moving the drive cuff in the first direction relative to the clot treatment component to allow the clot treatment component to expand.

23. 16. The method of claim 15, wherein the elongate member includes a guidewire sheath driving component, and moving the elongate member includes moving the guidewire sheath driving component in the second direction relative to the outer sheath to extend at least the portion of the clot treatment component beyond the outer sheath lumen.

24. 24. The method of claim 23, wherein moving the guidewire sheath driving component comprises causing movement of a guidewire sheath operably coupled to the guidewire sheath driving component, and wherein the clot treatment component is operably coupled to the guidewire sheath such that causing movement of the guidewire sheath comprises extending at least the portion of the clot treatment component beyond the outer sheath lumen.

25. 1. A catheter for treating a human patient, said catheter comprising: an outer sheath having an outer sheath lumen; an outer sheath drive component having an outer sheath drive component lumen, the outer sheath drive component slidably disposed within the outer sheath lumen and operably coupled to the outer sheath; a guidewire sheath including a guidewire sheath lumen configured to receive a guidewire, at least a portion of the guidewire sheath being slidably disposed within the outer sheath and laterally adjacent the outer sheath drive component; a guidewire sheath drive component slidably disposed within the outer sheath drive component, the guidewire sheath drive component operably coupled to the guidewire sheath; and a coagulation treatment component coupled to the guidewire sheath; a coagulation treatment drive component slidably disposed within the outer sheath drive component lumen and operably coupled to the coagulation treatment component; the catheter is configured to transition between (i) a first configuration, in which the clot treatment component is positioned within the outer sheath lumen, and (ii) a second configuration, in which at least a portion of the clot treatment component is exposed from the outer sheath lumen, in response to movement in response to at least one of (a) a first movement of the outer sheath drive component in a first direction relative to the guidewire sheath, and (b) a second movement of the guidewire sheath drive component in a second direction relative to the outer sheath; The catheter, wherein the clot treatment drive component is configured to transition the clot treatment component between (i) a first state in which the clot treatment component has a first dimension, and (ii) a second state in which the clot treatment component has a second dimension that is larger or smaller than the first dimension.

26. In the first state, the clot treating component has a first mechanical property; 26. The catheter of claim 25, wherein in the second state, the clot treating component has second mechanical properties.

27. the first mechanical property comprises at least one of a first radial force, a first tensile force, a first compressive force, and / or a first shape; 27. The catheter of claim 26, wherein the second mechanical property comprises at least one of a second radial force, a second tensile force, a second compressive force, and / or a second shape.

28. 26. The catheter of claim 25, wherein the clot treatment component includes a mechanical thrombectomy component extending radially outward from the guidewire sheath.

29. 26. The catheter of claim 25, wherein the clot treatment component includes a coring element having a proximally facing leading edge.

30. 26. The catheter of claim 25, wherein the clot treatment drive component is a first clot treatment drive component operably coupled to a first portion of the clot treatment component, and the catheter further comprises a second clot treatment drive component slidably coupled to a second portion of the clot treatment component.

31. The catheter of claim 30, wherein the first coagulation therapy drive component includes a first coagulation therapy drive component lumen, and the second coagulation therapy drive component is slidably disposed within the first coagulation therapy drive component lumen.

32. 26. The catheter of claim 25, wherein the second direction is opposite to the first direction.

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