Closure caps for sterilization or filling of medical supplies

Abstract

The present invention relates to a closure cap for sterilization or sterile filling of medical articles, particularly for sterilization of dialyzers and dialysis treatment kits, wherein a closure plug is attached to the body of the closure cap via a releasable or movable connector (132), and the closure plug can be moved from an open position that allows sterilization fluid to pass through to a fluid-sealing closed position.

Description

Technical Field

[0001]

[0001] The present invention relates to a closure cap for the sterilization or aseptic filling of medical articles, particularly for the sterilization of dialyzers and treatment sets for dialysis. More specifically, the present invention relates to a medical article having a fluid port and a closure cap according to the present invention.

Background Art

[0002]

[0002] Medical articles, such as dialyzers and treatment sets, particularly tube sets for dialysis and extracorporeal blood treatment, are used in the treatment of patients in various therapies. A requirement for using such medical articles in patient treatment is their sterility. To ensure the sterility of medical articles, such medical articles are subjected to a heat sterilization process, particularly a steam sterilization process, or a sterilization process using a sterilizing gas such as ethylene oxide. Further, in order to achieve low particle contamination of a dialyzer or other commercially provided medical articles, after passing through the rinsing step and the sterilization step in the production process, it is necessary to close the fluid ports of the dialyzer or medical article. "In-line" steam sterilization is a widely used sterilization method particularly for the sterilization of dialyzers in an economical industrial production process. Various embodiments of "in-line" steam sterilization are described in European Patent Application EP0427055A2 and International Patent Application WO2018 / 104498A9.

[0003]

[0003] According to "in-line" steam sterilization, the produced dialyzer is attached to a rinsing and sterilization device through the fluid ports of the dialyzer. Then, the dialyzer is rinsed in several steps, for example, using water, through the blood port and the dialysate port of the dialyzer. This process is used to remove unwanted residues generated by the production of the dialyzer, such as particles, residual solvents or residual polymers, from the inside of the dialyzer. In a further step, the dialyzer is usually sterilized, for example, by superheated steam at 121°C. Thus, superheated steam is introduced into the inside of the dialyzer through the blood port and / or the dialysate port, and thus the inside of the dialyzer is sterilized.

[0004]

[0004] For this sterilization procedure, precautions must be taken to prevent the dialyzer from being re-contaminated through the blood port and dialysate port, which remain open when the dialyzer is removed from the sterilization device, once it has been removed from the rinsing and sterilization device. To address this, sealing caps have been developed to connect the dialyzer to the rinsing and sterilization device via the blood port and dialysate port in a fluid and bacteria-free manner, and the sealing caps are functionally designed to seal the blood connection and dialysate connection when the dialyzer is removed from the rinsing and sterilization device.

[0005]

[0005] In addition, medical articles, particularly closure caps for the fluid ports of dialyzers, are also useful for resealing medical articles after use in treatment procedures. After the completion of an in vitro blood treatment session, the dialyzer may still be partially filled with treatment fluid and / or blood. For hygienic reasons, care must be taken to ensure that the treatment area is not contaminated with residual treatment fluid and / or blood from the patient when disassembling the dialyzer and treatment devices. Therefore, it is important to reseal used dialyzers.

[0006]

[0006] In this context, it should be noted that commercially available dialyzers typically have two fluid ports for blood. Furthermore, such dialyzers have at least one fluid port for the treatment fluid or filtrate generated in extracorporeal blood treatment. Generally, the dialyzers discussed in this application have two fluid ports for blood and two fluid ports for the treatment fluid, such as the dialyzer fluid. The geometric design of the fluid ports of a dialyzer is specified in standards such as DIN EN ISO 8637: March 2014. However, depending on the treatment procedure and geographical region, not all dialyzers on the market are designed in accordance with this standard.

[0007]

[0007] In addition to the requirement of sterilization of medical articles, the aseptic filling process is also very important in medical technology. In aseptic filling of medical containers, a sterile or aseptically pre-treated liquid is filled into the container to be filled. Such a filling method can be carried out by filling the medical container under sterile conditions using a closure cap.

[0008]

[0008] Patent application EP2114344A2 describes a closing cap for filling and closing a container for containing medical liquids, and a method for filling a container with medical liquids and closing the container, wherein the closing piece is positioned on the closing body of the closing part and is displaceable in an open position and a position that closes the passage of the closing body.

[0009]

[0009] Patent application EP0352540A2 describes a multi-part closure cap for a dialyzer fluid port, comprising first and second cap portions, wherein the first cap portion is attachable to the dialyzer fluid port, and the second cap portion is movable between an open position through which a sterile medium passes and a closed position. Object of the invention

[0010]

[0010] Based on the closure caps described in the prior art, and taking into account the requirements of existing processes for sterilization and aseptic filling of medical articles, there is a need to develop an alternative closure cap that is optimized in terms of manufacturing, handling, and functionality, and that can be used in sterilization or aseptic filling processes, and is functionally designed to seal sterilized or filled medical articles in a way that is impermeable to fluids and therefore impermeable to bacteria. [Overview of the Initiative]

[0011]

[0011] In a first aspect of the present invention, the problem is solved by a closing cap having the features of claim 1. Dependent claims 2 to 13 provide preferred embodiments.

[0012]

[0012] In a second aspect of the present invention, the problem is solved by a medical article comprising a fluid port and a closure cap according to any one of claims 1 to 13.

[0013]

[0013] In a third aspect of the present invention, the problem is solved by using a closure cap having the features described in any one of claims 1 to 13 for sterilization or aseptic filling. Description of the Invention

[0014]

[0014] The closure cap described according to the first aspect of the present invention is suitable for being placed on a fluid port of a medical article. In the open position of the closure cap, the closure cap is suitable for introducing fluid into the medical article. The fluid may be a sterilizing medium, such as a gas such as ethylene oxide, or superheated steam at 121°C, or a sterile or sterilized filling material such as a medical liquid. In the closed position, the closure cap is suitable for sealing the fluid port of a medical article in a way that prevents fluid and bacteria from passing through, and is particularly suitable for sealing the fluid port of a dialyzer to ensure the sterility and low particulate contamination of the dialyzer. In particular, the closure cap is configured to cooperate with the first fluid port of the dialyzer in a way that prevents fluid and / or liquid from passing through. If the connection between the closure cap and the fluid port of the dialyzer is impermeable to fluid or liquid, then the connection is also impermeable to bacteria, ensuring sterility and low particulate contamination. In particular, the closure cap may also be configured to cooperate with the blood port and / or dialysate port of a dialyzer for extracorporeal blood procedures in a fluid-free manner.

[0015]

[0015] Furthermore, the closure cap according to the present invention is also suitable for working as a connector between a medical article, particularly a first fluid port of a dialyzer, and a rinsing and sterilization device, particularly a device for "in-line" sterilization. The closure cap according to the first embodiment simplifies the process of industrial rinsing and sterilization procedures. The closure cap has a receiving portion through which a fluid sealing connection can be made to a medical article, particularly a first fluid port of a dialyzer. Furthermore, the closure cap according to the present invention can be connected to a rinsing and sterilization device in the open position of the closure cap to introduce a sterilization medium into a medical article, particularly to enable an "in-line" sterilization process or a sterilization process using a sterilization gas. Alternatively, the closure cap may be used in the open position of the closure cap to connect to a filling station for filling medical articles, such as medical containers, with medical fluids.

[0016]

[0016] The open and closed positions of the sealing cap according to the present invention are made possible by a closing plug that is releasably attached to the sealing cap. In the open position, the closing plug has a fluid channel through which a sterilization medium or medical filling material can flow. In the closed position of the closing plug, the fluid channel is blocked by the closing plug in a way that prevents fluid from passing through. The closing plug can be moved from the open position to the closed position by applying force. Appropriate means may be provided in the rinsing and sterilization device to move the closing plug from the open position to the closed position.

[0017]

[0017] According to the present invention, handling of the closure cap during the treatment procedure is also simplified. When using the closure cap according to the present invention on a dialyzer in an extracorporeal blood treatment process, the closure cap is removed immediately before the extracorporeal blood treatment of the dialyzer. Typically, after the patient has been treated with blood, it is then necessary to close the dialysate port of the dialyzer to prevent residual dialysate from spilling out of the dialyzer. The closure cap according to the present invention can be used for this purpose. In one embodiment, the closure cap may be configured to provide a seal that prevents fluid from passing through both the dialysate port and the blood port of the dialyzer. This improves the handling of the closure cap according to the present invention when setting up and disassembling the dialyzer during the process of performing extracorporeal blood treatment.

[0018]

[0018] Further details, features, and advantages of the present invention will become apparent from the following description and drawings. [Brief explanation of the drawing]

[0019] [Figure 1]

[0019] This is a schematic side view of the closing cap according to the present invention in the open position, in which the closing plug is releasably attached to the base body of the closing cap. [Figure 2]

[0020] This is a cross-sectional view along the central longitudinal axis A of the closing cap according to the present invention, in the open position of the closing cap, where the closing plug is releasably attached to the base of the closing cap. [Figure 3]

[0021] This is a cross-sectional view along the central longitudinal axis A of the closing cap according to the present invention, in the closed position of the closing cap, where the closing plug blocks the fluid channel of the closing cap in a manner that prevents fluid from passing through. [Modes for carrying out the invention]

[0020]

[0022] The present invention will be described below with reference to the individual embodiments illustrated in Figures 1 to 3. The individual embodiments described herein are not limited to those shown in Figures 1 to 3.

[0021]

[0023] In a first embodiment, the present invention relates to a closure cap 100 for a fluid port of a medical article, particularly for a fluid port of a dialyzer, the closure cap comprising a base 101 and a closure plug 130, the base and the closure plug being arranged along a central longitudinal axis A and connected to each other, the base 101 comprising a circumferential side wall 103 having an inner 103A and an outer 103B, an end wall 108 having an inner 108A and an outer 108B, and a fluid channel 104 arranged symmetrically with respect to the first circumferential side wall 103, the inner 105A facing the fluid channel and the outer 105A facing the inner 103A of the fluid channel and the inner 1 The fluid channel 104 has a circumferential wall 105 having an outer side 105B facing 03A, and a first open end 106 and a second open end 107 for the passage of fluid, the circumferential side wall 103 is circumferentially connected to the outer side 105B of the wall 105 of the fluid channel 104 via an end wall 108 in a manner that does not allow fluid to pass through, and a closing plug 130 is detachably or slidably attached to the base, and the closing plug 130 is sized such that it can be inserted into the fluid channel 105 from an open position where fluid can flow into the fluid channel through the first open end 106 to a fluid-sealing closed position.

[0022]

[0024] In the context of the present invention, “dialyzer” is understood to mean a hollow fiber membrane filter for extracorporeal hematological treatment having at least two fluid ports for blood and at least one other fluid port for dialysate or filtrate. In the context of the present invention, the term dialyzer refers to such a hollow fiber membrane filter used in extracorporeal hematological treatment. In particular, in the context of the present application, the term “dialyzer” also includes a hollow fiber membrane filter used as a hematological treatment filter in dialysis, hemodiafiltration, hemofiltration, plasma separation, or blood oxygenation.

[0023]

[0025] For the purposes of the present application, the term "closure cap" is understood to mean a closure element that closes the opening of a fluid port of a medical article in a fluid-impermeable manner in the closed position. For the purposes of the present application, "fluid-impermeable" means that a fluid, such as a rinsing liquid or a sterilizing gas such as superheated steam, cannot pass through the component section of the closure cap or cannot leak from the opening closed by the closure cap during use.

[0024]

[0026] For the purposes of the present application, the term "superheated steam" is used equivalently to the technically common terms "moist heat" or "saturated steam". For the purposes of the present application, this refers to gaseous water having a temperature above 100°C. Further, during the steam sterilization of a medical article, pressure is applied to accelerate and improve the sterilization process. Such pressure ranges from 1 to 5 bar. For the purposes of the present application, the terms "superheated water steam", "moist heat", or "saturated steam" are also understood to mean gaseous water at a temperature of 110 - 130°C, particularly 121°C, and at a pressure of 1 to 5 bar, particularly also 2.5 bar.

[0025]

[0027] In the context of the present application, the term "base body" is understood to mean the component part of the closure cap that surrounds the receiving part for the fluid port of the medical article, i.e., is particularly suitable for cooperating with the fluid port of the medical article in a fluid-impermeable manner.

[0026]

[0028] For the purposes of the present application, the term "circumferential side wall" means a side wall extending along the circumference. This means that a non-breaking line can be drawn circumferentially on the side wall. A section of the circumferential side wall can have an inner or outer surface whose shape is substantially cylindrical. The circumferential side wall can further include shoulders, protrusions, and cross-sectional protrusions. In certain embodiments, the circumferential side wall is geometrically configured to cooperate with the fluid port of a medical article, particularly the dialysate port of a dialyzer, in a fluid-impermeable manner.

[0027]

[0029] For the purposes of this invention, the term “end wall” is understood to mean a component section that connects a circumferential side wall to a fluid channel that is circumferentially and fluid-impermeable, and is centrally symmetrically arranged.

[0028]

[0030] For the purposes of this application, the term “receiving portion” is understood to mean a section of a closure cap into which a fluid port of a medical article, in particular a dialysate port or blood port of a dialyzer, can be inserted in a fluid-impermeable manner. The receiving portion may be formed by a section of circumferential sidewalls, a fluid channel wall, and an end wall, the fluid channel wall of which can then be inserted into the opening of a fluid port of a medical article, in particular a dialysate port of a dialyzer. However, alternatively, the closure cap may be configured to accept, for example, a blood port of a dialyzer, so that the fluid channel can be connected to a geometrically different fluid port of the medical article.

[0029]

[0031] The term “closure plug” is understood to mean a component body that may be fully or partially inserted into the fluid channel of a closure cap, and thus capable of blocking the fluid channel in a way that prevents fluid from passing through. In the basic configuration of the closure cap, i.e., the basic configuration after manufacture, the closure plug is initially releasably connected to the base of the closure cap. In this state, a fluid channel, which is centrally symmetrically arranged with respect to a first circumferential sidewall, is through which fluid can pass via the first and second open ends of the fluid channel. When fluid can flow through the fluid channel, the closure plug, and therefore the sealing cap, is also in the “open position” within the scope of this application. When the closure plug is inserted into the fluid channel in the fluid-sealed position, the closure plug, and therefore the sealing cap, is also in the “closed position” within the scope of this application.

[0030]

[0032] In the context of this application, the term “releasable connection” is understood to mean a connection comprising a substrate and a closing plug that can be released by a predetermined force. In particular, a releasable connection can also be understood as a predetermined breaking point where the connection can be broken by a predetermined force without impairing the function of the closing cap. The connection may also be provided to be slidable. Such embodiments have a connection between a closing plug and a substrate made of a material having particularly high ductility.

[0031]

[0033] The central longitudinal extension axis is understood to be the geometric axis of the closing cap that passes through the center of the centrally arranged fluid channel and defines the longitudinal extension of the closing cap with respect to translational movement from an open position to a closed position within the centrally arranged fluid channel of the closing plug.

[0032]

[0034] In another embodiment of the first aspect of the present invention, the closing cap is characterized in that the closing plug is removably attached to the end wall 108, in particular to the outer surface 108A of the end wall 108, or to the first open end 106 of the fluid channel on the circumferential wall 105. Corresponding embodiments are shown in Figures 1 and 2.

[0033]

[0035] In a further embodiment of the first aspect of the present invention, the closing plug is characterized in that the closing plug has a section having lateral passage openings 131 that allow fluid to flow when the closing plug is in the open position, and are covered by the inside of the wall of the fluid channel in a way that prevents fluid from passing through when the closing plug is in the closed position. According to this embodiment, fluid guidance in the open position of the closing cap is made possible through the fluid channel by the lateral openings of the closing plug. Advantageously, the closing plug may be inserted into the fluid channel 104, and the lateral openings are covered by the inside 105A of the wall 105 of the channel 104 in a way that prevents fluid from passing through when the closing position. In particular, in this embodiment, the closing plug may be recessed into the channel 104.

[0034]

[0036] In another embodiment of the first aspect of the present invention, the closure cap is characterized in that the wall 105 of the fluid channel 104, which is center-symmetric with respect to the first circumferential side wall 103, has a substantially cylindrical shell-shaped inner surface 105A. According to this embodiment, the closure plug is also designed to have a cylindrical section so that it can be fitted into the channel in a fluid-impermeable manner, meaning that it is in a fluid- and bacteria-proof closed position within the fluid channel. In particular, the cylindrical shape of the fluid channel and the closure plug is advantageous in terms of a bacteria-proof seal between the closure plug and the inner surface 105A of the wall 105 of the fluid channel 104.

[0035]

[0037] In particular, according to this embodiment, the closing plug is configured to have a cylindrical portion 134 having an outer surface 134A that cooperates with the inner surface 105A of the cylindrical shell shape of the wall 105 of the fluid channel 104, which is arranged symmetrically with respect to the first circumferential side wall 103, in a fluid-impermeable manner when the closing plug is in the closed position.

[0036]

[0038] In another embodiment of the first aspect of the present invention, the closing cap 100 is characterized in that, in the open position of the closing plug, the closing plug 130 is connected to the wall 105 at the first open end 106 of the fluid channel via one or more portions of a releasable connector 132. According to one embodiment, the releasable connector may be formed by circumferentially connecting to the wall at the first open end 106 of the fluid channel. In an alternative embodiment, the circumferentially releasable connector may be divided into a plurality of sections of the releasable connector. If the plurality of sections of the releasable connector are circumferentially connected to the wall 105 at the first open end 106 of the fluid channel, advantageously, side openings may be provided in the closing plug between each section.

[0037]

[0039] In another embodiment of the first aspect of the present invention, the closing cap 100 is characterized in that, when the closing plug is in the open position, the closing plug 130 has a plurality of circumferential pinnacles (133) on its sides that are circumferentially connected to the wall 105 at the first open end 106 of the fluid channel via sections of a connectable portion 132.

[0038]

[0040] In another embodiment of the first aspect of the present invention, the closure cap 100 is characterized in that one or more sections of the releasable connection 132 are releasable with a force of 10 to 100 N, more specifically 20 to 60 N, and even more specifically 25 to 45 N. In particular, according to this embodiment, the releasable connection is sufficiently stable to allow the closure cap to withstand the mechanical and thermal requirements of the rinsing and sterilization processes, or alternatively, the filling process. Furthermore, the force is such that the functionality of the closure cap with respect to the aforementioned processes can be handled.

[0039]

[0041] In another embodiment of the first aspect of the present invention, the closing cap 100 is characterized in that one or more portions of the releasable connection 132 comprise an adhesive connection, a snap connection, or a material weak portion. With respect to the adhesive connection, an adhesive connection or a heat-sealed connection is particularly preferred. Particularly advantageous is that the releasable connection consists of a material weak portion that can be broken with a predetermined force. This has the advantage that, in the open position, the closing cap can be manufactured as a single, integrated closing cap, for example, in this case by an injection molding process, which represents an economically preferred manufacturing process. Furthermore, the closing cap can be two parts in the closed position.

[0040]

[0042] In another embodiment of the first aspect of the present invention, the closing cap 100 is characterized in that the inner surface 105A of the wall 105 of the fluid channel 104 includes a shoulder that reduces the clear width of the fluid channel 104. Thus, the shoulder forms a stopper that defines the depth to which the closing plug 130 penetrates the fluid channel 104 in the closed position. Due to the predetermined penetration depth of the closing plug, it can be visually recognized as early as possible that the closing plug has reached a sufficient penetration depth in the fluid channel 104, and therefore the sealing cap satisfies the requirement that fluid and bacteria are impermeable in the closed position.

[0041]

[0043] In another embodiment of the first aspect of the present invention, the closure cap 100 is characterized in that the closure cap includes an annular shoulder 109 on the outer surface 108B of the end wall. Preferably, one or more sections of the openable connector 132 are connected to this annular shoulder. This embodiment is shown in Figures 2 and 3. Advantageously, the annular shoulder serves to establish a fluid connection to a fluid port of a filling device, rinsing device, or sterilization device. In this embodiment, the annular shoulder 109 may be received at the opening of the fluid port of the filling device, rinsing device, or sterilization device, thereby providing a fluid and bacteria-proof connection between the closure cap and the filling device, rinsing device, or sterilization device. Thus, when the closure cap is in the open position, fluid can be introduced through the filling device, rinsing device, or sterilization device into the fluid channel 104 and further into the medical article, particularly into the dialyzer. After the completion of the filling step, rinsing step, or sterilization step, the closure plug can be brought into the closed position using a punch tool, which may be part of the filling device, rinsing device, or sterilization device. In this process, one or more releasable connections between the substrate and the closing plug are broken, and the closing plug is inserted into the channel 104.

[0042]

[0044] In another embodiment of the first aspect of the present invention, the closing cap 100 is characterized in that the receiving portion 102 is geometrically configured to cooperate with the blood port and / or dialysate port of the dialyzer in a fluid-free manner, in accordance with DIN EN ISO 8637:2014 March.

[0043]

[0045] In another embodiment of the first aspect of the present invention, the closure cap 100 is characterized in that the closure cap is made of a plastic material selected from the group of thermoplastics, particularly polyethylene, polypropylene, or thermoplastic elastomers, or blends or copolymers thereof. Polypropylene homopolymers and copolymers are particularly preferred. Such materials are dimensionally stable, especially when subjected to heat sterilization, and are therefore suitable for bacterial and fluid-impermeable cooperation with fluid ports of medical articles at high temperatures, particularly for cooperation with dialysate ports and blood ports of dialyzers.

[0044]

[0046] In a second aspect, the present invention relates to a medical article comprising at least one fluid port provided with a closure cap as described in one embodiment of the first aspect. The medical article may, in particular, be a dialyzer, a dialysis tube set, a dialysis treatment set, or a container for holding medical fluids.

[0045]

[0047] Furthermore, in a third aspect, the present invention relates to the use of a closure cap described in any embodiment of the first aspect for rinsing, sterilizing, or aseptically filling medical articles. [Explanation of Symbols]

[0046] A... Longitudinal axis 100... Closing cap 101... Base of the closing cap 102...Receiving part for working with the fluid port 103…Circumferential side wall 103A...Inside of the circumferential side wall 103B...Outer side of the circumferential side wall 104… Fluid channel 105...Circumferential wall of a fluid channel 105A...Inside of the circumferential fluid channel 105B...Outside of the circumferential fluid channel 106...First open end of the fluid channel 107...Second open end of the fluid channel 108... End wall of the circumferential side wall 108A...Inside of the end wall of the circumferential side wall 108B...Outside of the end wall of the circumferential side wall 109... Circular shoulder 130... Closed plug 131... Side opening of the closing plug 132...Releasable connection between the base and the closing cap 133... Pinnacle of the closing cap 134...Cylindrical section of a closing plug 134A...Outside of the cylindrical section of the closing plug

Claims

1. A closure cap for a fluid port of a medical device, particularly for a fluid port of a dialyzer, comprising a base and a closure plug, wherein the base and the closure plug are arranged along a central longitudinal axis and connected to each other. The aforementioned substrate is A fluid channel comprising: a circumferential side wall having an inner and an outer side; an end wall having an inner and an outer side; a fluid channel arranged symmetrically with respect to the first circumferential side wall, the fluid channel having an inner side facing the fluid channel and an outer side facing the inner side of the circumferential side wall; and a first open end and a second open end for allowing fluid to pass through. The circumferential side wall is fluid-sealed in the circumferential direction to the outside of the wall of the fluid channel via the end wall. A closing cap characterized in that the closing plug is attached to the base via a releasable or slidable connector, and the closing plug is sized such that it can be inserted into the fluid channel from an open position where fluid can flow into the fluid channel through the first open end to a fluid-sealing closed position.

2. The closing cap according to claim 1, characterized in that the closing plug is removably attached to the circumferential wall at the end wall or at the first open end of the fluid channel.

3. The closing cap according to claim 1 or 2, characterized in that the closing plug has a section having a side passage opening that allows fluid to flow when the closing plug is in the open position and is covered by the inside of the wall of the fluid channel in a manner that prevents fluid from passing through when the closing position is closed.

4. A closing cap according to any one of claims 1 to 3, characterized in that the wall of the fluid channel, which is arranged symmetrically with respect to the first circumferential side wall, has a substantially cylindrical shell shape inside.

5. The closing cap according to claim 4, characterized in that the closing plug comprises a cylindrical portion having an outer surface that cooperates with the inner surface of the cylindrical shell of the wall of the fluid channel, which is arranged symmetrically with respect to the first circumferential side wall, in a fluid-impermeable manner at the closing position of the closing plug.

6. A closing cap according to any one of claims 1 to 5, characterized in that, in the open position of the closing plug, the closing plug is connected to the wall at the first open end of the fluid channel via one or more portions of a releasable connection portion.

7. The closing cap according to claim 6, characterized in that, in the open position of the closing plug, the closing plug has a plurality of circumferential pinnacles on its side surface that are circumferentially connected to the wall at the first open end of the fluid channel via a section of a connectable portion that can be opened.

8. The closing cap according to claim 6 or 7, characterized in that one or more of the releasable connection portion can be released with a force of 10 to 100 N.

9. A closing cap according to any one of claims 6 to 8, characterized in that one or more of the releaseable connection portion consists of an adhesive connection portion, a snap connection portion, or a weak portion of the material.

10. The closing cap according to any one of claims 1 to 9, characterized in that the inner surface of the wall of the fluid channel has a shoulder portion that reduces the inner width of the fluid channel.

11. The closing cap according to any one of claims 1 to 10, characterized in that the closing cap is an integrated closing cap in the open position.

12. The closing cap according to any one of claims 1 to 11, characterized in that the wall of the fluid channel protrudes beyond the end wall, and an annular shoulder is formed on the end wall of the closing cap.

13. The closing cap according to any one of claims 1 to 12, characterized in that the receiving portion is geometrically configured to cooperate with the blood port and / or dialysate port of the dialyzer in accordance with DIN EN ISO 8637: March 2014 in a fluid-free manner.

14. A medical article comprising at least one fluid port provided with a closure cap according to any one of claims 1 to 13.

15. Use of the sealing cap according to any one of claims 1 to 13 for rinsing, sterilizing, or aseptically filling medical articles.

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