Nano Transport Tool

Abstract

The present invention provides nano-delivery tools that realize targeted substance delivery processes, enhance immunity, alleviate the three major diseases, and have anti-cancer, anti-cardiovascular, and anti-inflammatory effects. The nano-delivery tool (100) includes a rectangular adsorption structure (110), an elliptical or circular Bacillus subtilis structure (120), and an elliptical or circular active ingredient structure (130). The material of the adsorption structure is nanoscale montmorillonite. The Bacillus subtilis structure covers the outside of the adsorption structure. The active ingredient structure covers the outside of the Bacillus subtilis structure, and the Bacillus subtilis structure is located between the active ingredient structure and the adsorption structure.

Description

[Technical Field]

[0001] The present invention relates to delivery tools, and more particularly to nano-delivery tools. [Background technology]

[0002] Drug carriers / encapsulation platforms play an important role in drug delivery and modern medicine, and such systems are widely applicable in fields such as cancer treatment, infection control, gene therapy, and vaccine delivery. However, many challenges remain to be overcome in terms of biosafety, targeting, manufacturing process, cost, and regulations. A common problem is insufficient absorption rate, which reduces target specificity and therapeutic efficiency. Summary of the Invention [Problem to be solved by the invention]

[0003] The embodiments of the present invention provide a nano-delivery tool that can realize targeted substance delivery processes, enhance immunity, alleviate the three major diseases, and have anti-cancer, anti-cardiovascular and anti-inflammatory effects. [Means for solving the problem]

[0004] One embodiment of the present invention provides a nano-delivery tool including an adsorbent structure, a Bacillus subtilis structure, and an active ingredient structure. The material of the adsorbent structure is nanoscale montmorillonite. The Bacillus subtilis structure covers the outside of the adsorbent structure. The active ingredient structure covers the outside of the Bacillus subtilis structure, and the Bacillus subtilis structure is located between the active ingredient structure and the adsorbent structure.

[0005] In one embodiment, the Bacillus subtilis structure is a unicellular structure.

[0006] In one embodiment, the active ingredient structure is a multi-molecular structure.

[0007] In one embodiment, the active ingredient structure is made from one or a combination of two or more of kudzu root, hawthorn, garlic, onion, red yeast rice, green tea, black sesame, walnut, Danshen, Rhodiola rosea, Astragalus root, and Cistanche salicina.

[0008] In one embodiment, the nano-montmorillonite has a nanoscale range of 20 to 100 nanometers. [Effects of the Invention]

[0009] Based on the above, the present invention can achieve target characteristic processes, enhance immunity, alleviate the three major diseases, and has the effects of anti-cancer, anti-cardiovascular disease and anti-inflammatory.

[0010] Furthermore, the nano-montmorillonite, which is the adsorption structure of the present invention, has a higher specific surface area, adsorption capacity, dispersibility and reaction activity.

[0011] In addition, this invention adopts the structure of Bacillus subtilis combined with nano-montmorillonite, which has strong adsorption ability, so that it can remain in the human intestines for a long time, induce good bacteria, suppress bad bacteria, and is less likely to spoil, achieving higher efficiency and improving the effects on the human immune system and intestinal defecation.

[0012] In addition, according to the actual problem to be solved, the present invention combines the active ingredient structure of an appropriate material with nano-montmorillonite, which has strong adsorption ability, to introduce the medicinal effects of the active ingredient structure and achieve better therapeutic effects. [Brief explanation of the drawings]

[0013] [Figure 1] 1 is an illustration of one embodiment of a nano delivery tool in accordance with the present invention; DETAILED DESCRIPTION OF THE INVENTION

[0014] To make the present invention easier to understand, the following embodiments are given in detail in conjunction with the drawings.

[0015] The present invention will be described in detail below with reference to the accompanying drawings, but the embodiments provided do not limit the scope of the present invention. The drawings are for illustrative purposes only and are not drawn to scale. For ease of understanding, the same elements will be labeled with the same reference numerals in the following description.

[0016] In the description of each embodiment, the term "nanocarrier" refers to a nanoscale carrier system with a scale of 1 to 100 nanometers (nm) that coats, carries, and delivers specific substances (drugs, genes, proteins, etc.) to a target location. The design objective is to improve delivery efficiency, stability, targetability, and therapeutic effects, and it is often applied in fields such as biomedicine, drug delivery, cancer treatment, and smart materials.

[0017] In the description of each embodiment, the term "targeted specific process" refers to a highly specific and selective manufacturing technology designed for a specific target (material, cell, structure, function, etc.) to achieve the purpose of precise manufacturing, control, or effect, and can be applied in the fields of biomedicine, drug manufacturing, and nanotechnology. Among them, the biomedical manufacturing process refers to the preparation process of "targeted drug delivery" using nanoparticles.

[0018] FIG. 1 is an illustration of one embodiment of a nano-delivery tool of the present invention. Referring to FIG. 1, the nano-delivery tool 100 of the present invention is composed of powder particles, realizing a target-specific substance delivery process. The nano-delivery tool 100 includes an adsorption structure 110, a Bacillus subtilis structure 120, and an active ingredient structure 130. The adsorption structure 110, the Bacillus subtilis structure 120, and the active ingredient structure 130 are also referred to as an adsorption layer, a Bacillus subtilis layer, and an active ingredient layer, respectively. The shape of the adsorption structure 110 is, for example, rectangular, and the shapes of the Bacillus subtilis structure 120 and the active ingredient structure 130 are, for example, oval or circular. The Bacillus subtilis structure 120 covers the outside of the adsorption structure 110. The active ingredient structure 130 covers the outside of the Bacillus subtilis structure 120 , and the Bacillus subtilis structure 120 is located between the active ingredient structure 130 and the adsorptive structure 110 .

[0019] The adsorption structure 110 is the innermost layer (or first layer) of the nano-delivery tool 100. The adsorption structure 110 refers to a microscopic or nanoscale structural design for adsorbing specific molecules, ions, or particles on a material surface or interface. The material of the adsorption structure 110 is nanoscale montmorillonite, which allows the two layers of the outer Bacillus subtilis structure 120 and the active ingredient structure 130 to adsorb the molecules after fermentation.

[0020] Nanoscale montmorillonite is a montmorillonite material whose layer dimensions have reached the nanoscale through exfoliation or modification treatment, with the nanoscale range of nanoscale montmorillonite being 20 to 100 nanometers. By using nanoscale montmorillonite as the adsorption structure 110, the natural layered structure of montmorillonite is maintained while its size is reduced to the nanoscale, resulting in higher specific surface area, adsorption capacity, dispersibility, and reactivity. As a result, it is widely used in the fields of polymer composite materials and drug carriers.

[0021] The Bacillus subtilis structure 120 is the middle layer (or second layer) of the nano-delivery tool 100. The Bacillus subtilis structure 120 refers to the morphological and cellular structural characteristics of Bacillus subtilis, which is fermented and adsorbed to the adsorption structure 110. The Bacillus subtilis structure 120 is a unicellular structure and is a beneficial bacterium, so it first covers the outside of the adsorption structure 110. The unicellular structure refers to the basic structural form of an organism consisting of only one cell. This cell simultaneously performs all vital functions, including metabolism, proliferation, response to external stimuli, and genetic information transmission. These structural characteristics give it excellent survival ability and application potential, allowing it to inhabit the human intestine for a long time, induce beneficial bacteria, inhibit harmful bacteria, and resist decay, achieving higher efficiency and improving the human immune system and intestinal defecation.

[0022] The active ingredient structure 130 is a multi-molecular structure whose particle size is larger than that of the single-cell structure of the Bacillus subtilis structure 120, and is therefore placed in the outermost layer structure of the nano-delivery tool 100, thereby introducing the medicinal ingredient of the active ingredient structure 130. A multi-molecular structure refers to an ordered or functional combination structure composed of multiple molecules, and these molecules can form a stable complex or layered arrangement through physical adsorption, chemical bonding, or non-covalent bonding forces.

[0023] In one embodiment, the material of the active ingredient structure 130 is selected from one or a combination of two or more of Kudzu Root, Hawthorn, Garlic, Onion, Red Yeast Rice, Green Tea, Black Sesame, Walnut, Danshen, Rhodiola, Astragalus, and Cistanche, and the active ingredient structure 130 is a molecule or chemical structure of an active substance responsible for exerting an adsorption function or therapeutic effect in the nano delivery tool 100.

[0024] In one embodiment, kudzu root refers to the dried tuberous root of the legume plant Pueraria lobata, whose main components include isoflavones (such as puerarin and daidzein), starch, and saponin. The effects of using kudzu root as the material for the active ingredient structure 130 include vasodilation, lowering blood pressure, improving menopausal symptoms, promoting blood circulation, and detoxifying alcohol and protecting the liver.

[0025] In one embodiment, hawthorn is the dried mature fruit of the crataegus pinnatifida, a plant of the Rosaceae family, and the efficacy of using hawthorn as the material for the active ingredient structure 130 is to promote digestion, lower blood lipids, lower cholesterol, promote blood circulation, and remove blood clots.

[0026] In one embodiment, garlic is the bulb of Allium sativum, a plant of the lily family, and garlic is rich in sulfur-containing compounds (such as allicin). The efficacy of using garlic as the material for the active ingredient structure 130 is antibacterial, antiviral, blood pressure lowering, blood lipid lowering, antioxidant, and immune enhancement.

[0027] In one embodiment, the onion is a bulb portion of Allium cepa, a plant of the Liliaceae family. Onions are rich in sulfides (such as allyl propyl sulfide), quercetin, polyphenols, and vitamin C. The efficacy of using onions as a material for the active ingredient structure 130 is antioxidant, cholesterol-lowering, anti-inflammatory, and blood circulation promoting.

[0028] In one embodiment, red yeast rice is a fermented product produced by fermenting grains (mainly rice) with Monascus purpureus, and the effects of using red yeast rice as a material for the active ingredient structure 130 include lowering blood lipids, regulating cholesterol, promoting blood circulation, and protecting the liver.

[0029] In one embodiment, green tea contains catechins, tea polyphenols, caffeine, etc., and the effects of using green tea as a material for the active ingredient structure 130 include antioxidant, metabolism promotion, fat reduction, blood pressure reduction, and anti-cancer.

[0030] In one embodiment, black sesame is the black seed of sesame, which is rich in nutrients such as vegetable oil, calcium, iron, and vitamin E. The effects of using black sesame as the material for the active ingredient structure 130 include strengthening the liver and kidneys, preventing gray hair, lubricating the intestines and promoting bowel movements, and antioxidation.

[0031] In one embodiment, walnuts are rich in nutrients such as healthy fats (such as omega-3 fatty acids), protein, dietary fiber, vitamin E, potassium, and magnesium, and the effects of using walnuts as the material for the active ingredient structure 130 include improving brain function, moisturizing the lungs, strengthening the kidneys, and antioxidant properties.

[0032] In one embodiment, the danshen is the dried root of Salvia miltiorrhiza, a plant in the Labiatae family. The danshen is rich in active ingredients such as tanshinone and salvianolic acid, and the effects of using the danshen as the material for the active ingredient structure 130 include promoting blood circulation, clearing blood congestion, anti-inflammatory, protecting the cardiovascular system, and improving blood circulation.

[0033] In one embodiment, rhodiola is the root and rhizome of Rhodiola rosea, a plant of the Sedum family, which is rich in many bioactive ingredients such as rhodiolaside, phenolic acids, and flavonoids. The efficacy of using rhodiola as a material for active ingredient structure 130 includes anti-fatigue, immune system strengthening, antioxidant properties, and nervous system regulation.

[0034] In one embodiment, the Astragalus root is the dried root of the legume Astragalus membranaceus, which is rich in components such as Astragalus polysaccharides, saponins, and amino acids. The effects of using Astragalus root as the material for the active ingredient structure 130 are to replenish qi and firm the body surface (fuqi gubiao), strengthen immunity, have diuretic properties, and are anti-fatigue.

[0035] In one embodiment, Cistanche salsa is rich in active ingredients such as emodin, saponin, and phenylpropanoids, and the effects of using Cistanche salsa as the material for the active ingredient structure 130 include strengthening the kidneys and enhancing sexual energy, lubricating the intestines and promoting bowel movements, anti-fatigue, and anti-aging.

[0036] As described above, the present invention can achieve target characteristic processes, enhance immunity, alleviate the three major diseases, and has the effects of anti-cancer, anti-cardiovascular disease, and anti-inflammatory.

[0037] Furthermore, the nano-montmorillonite, which is the adsorption structure of the present invention, has a higher specific surface area, adsorption capacity, dispersibility and reaction activity.

[0038] In addition, this invention adopts the structure of Bacillus subtilis combined with nano-montmorillonite, which has strong adsorption ability, so that it can remain in the human intestines for a long time, induce good bacteria, suppress bad bacteria, and is less likely to spoil, achieving higher efficiency and improving the effects on the human immune system and intestinal defecation.

[0039] In addition, according to the actual problem to be solved, the present invention combines the active ingredient structure of an appropriate material with nano-montmorillonite, which has strong adsorption ability, to introduce the medicinal effects of the active ingredient structure and achieve better therapeutic effects.

[0040] Although the present invention has been described using the above-mentioned embodiments, it is not limited thereto, and those skilled in the art can make various modifications and improvements without departing from the spirit and scope of the present invention. Therefore, the scope of protection of the present invention is defined by the scope of the attached utility model claims. [Explanation of symbols]

[0041] 100 Nano Carrying Tool 110 Adsorption structure 120 Bacillus subtilis structure 130 Active ingredient structure 140 Edible Gel Structure

Claims

1. an adsorption structure in which the material is nanoscale montmorillonite; a Bacillus subtilis structure covering the outside of the adsorption structure; an active ingredient structure that coats the outside of the Bacillus subtilis structure; wherein the Bacillus subtilis structure is located between the active ingredient structure and the adsorption structure.

2. The nano-delivery tool of claim 1 , wherein the Bacillus subtilis structure is a unicellular structure.

3. The nano-delivery tool according to claim 1 , wherein the active ingredient structure is a multi-molecular structure.

4. The nano-delivery tool according to claim 1, wherein the material of the active ingredient structure is selected from one or a combination of two or more of kudzu root, hawthorn, garlic, onion, red koji, green tea, black sesame, walnut, Danshen, Rhodiola rosea, Astragalus root, and Cistanche salicina.

5. The nano-delivery tool according to claim 1, wherein the nano-scale montmorillonite has a nano-scale range of 20 to 100 nanometers.

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