Implants

The implant's surface structure with larger cavities than openings enables drug storage and slow release, addressing slow bone cell growth and vascular clogging issues, enhancing recovery and preventing restenosis.

JP7605920B2Active Publication Date: 2024-12-24SENTRONIC INT CORP
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Patent Information

Application Number
JP2023129262
Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
Priority Date
2022-06-06
Filing Date
2023-08-08
Publication Date
2024-12-24
Estimated Expiration
2042-08-01

AI Technical Summary

Technical Problem

Existing implants, such as artificial tooth roots and vascular stents, face challenges in accelerating bone cell proliferation and preventing vascular clogging due to slow cell growth and aggregation, respectively.

Method used

The implant features a surface structure with openings and cavities, where the cavities have a larger cross-sectional area than the openings, allowing drugs to be applied and stored within, slowly releasing to promote bone cell growth or prevent vascular clogging.

Benefits of technology

The implant effectively stores and releases drugs to enhance bone integration and prevent vascular stent clogging, thereby reducing recovery time and surgical complications.

✦ Generated by Eureka AI based on patent content.

Smart Images

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Abstract

To provide implant capable of attaching more drugs in order to promote or slow the growth of affected cells in artificial graft implantation surgery.SOLUTION: Implant used as a blood vessel stent B' includes multiple strip structures 101, and multiple tube bodies 102 formed on the strip structures 101. One end of the tube body 102 is connected to the strip structure 101, and the other end is a free end and has an opening 11. A cavity 12 is formed inside each tube body 102, and the opening 11 communicates with the cavity 12, and an outside surface is formed on the end of the free end of each tube body 102.SELECTED DRAWING: Figure 9
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Description

[Technical field]

[0001] The present invention relates to an artificial implant to be implanted in a living body, and more particularly to a surface structure of the implant. [Background technology]

[0002] There are various surgical procedures for embedding artificial implants in living bodies. Examples of artificial implants embedded in such procedures, so-called artificial implants, include artificial tooth roots used in dental regeneration and vascular stents used in catheter surgery for myocardial infarction. In dental regeneration, a small hole is made in the patient's alveolar bone, and an artificial tooth root is inserted and fixed, and bone cells in the alveolar bone are proliferated over time, and the artificial tooth root is firmly fixed and bonded to the alveolar bone. However, since the proliferation rate of bone cells is quite slow, patients are forced to live an inconvenient life for a long period after surgery, so how to speed up the proliferation rate of bone cells is a major issue in dental regeneration. On the other hand, after cardiac catheterization, clogging of the vascular stent due to aggregation in the blood vessels is likely to occur, so how to suppress aggregation and prevent clogging of the vascular stent is a major issue in cardiac catheterization. Summary of the Invention [Problem to be solved by the invention]

[0003] The present invention has been made in consideration of the shortcomings of the prior art, and aims to provide an implant capable of attaching a larger amount of a drug for promoting or retarding the proliferation of diseased cells during implantation surgery of an artificial graft. [Means for solving the problem]

[0004] In order to achieve the above object, the present invention proposes an implant, characterized in that the implant includes an outer surface in which a plurality of openings are formed, and a plurality of cavities each communicating with the plurality of openings.

[0005] The maximum cross-sectional area of ​​the plurality of cavities is greater than the cross-sectional area of ​​the plurality of openings.

[0006] The implant includes a plurality of communication passages, each of which has one end communicating with one of the openings and the other end communicating with one of the cavities.

[0007] The longitudinal cross-sectional shape of the plurality of cavities is circular, elliptical, egg-shaped or triangular.

[0008] The cross sections of the plurality of cavities are parallel to the outer surface, and the cross-sectional area increases with increasing distance from the outer surface.

[0009] The implant is characterized in that it is an artificial tooth root or a vascular stent.

[0010] In order to achieve the above object, the present invention further proposes an implant for use as a vascular stent, the implant comprising: Each one is shaped like a long, thin rod. Multiple Strip Structure A plurality of strip structures constituting a mesh tube and, a plurality of tubes formed on the strip structure; Each of the tubes has one end connected to the strip structure and the other end free and having an opening, and a cavity is formed inside each of the tubes; A cavity is in communication with the opening, and an outer surface is formed at the end of the free end of each of the tubes. It is characterized by the above. Effect of the Invention

[0011] As described above, according to the implant of the present invention, a plurality of cavities having openings are formed on its outer surface, and thus by applying a drug to the outer surface of the implant, the cavities can be filled with a drug. In addition, since the maximum cross-sectional area of ​​the cavities is larger than the cross-sectional area of ​​the openings, the drug filled in the cavities does not immediately flow out of the openings, but is instead retained in the cavities and released slowly. [Brief description of the drawings]

[0012] [Figure 1] FIG. 1 is a perspective view showing a first embodiment of the present invention. [Diagram 2] FIG. 2 is a schematic cross-sectional view showing a cavity of the first embodiment of the present invention. [Diagram 3] 3 is a schematic cross-sectional view showing another embodiment of the cavity portion shown in FIG. 2. FIG. [Figure 4] 4 is a schematic cross-sectional view showing another aspect of the cavity portion of the first embodiment of the present invention. FIG. [Diagram 5] 5 is a schematic cross-sectional view showing another embodiment of the cavity portion shown in FIG. [Figure 6] FIG. 11 is a perspective view showing a second embodiment of the present invention. [Figure 7] FIG. 4 is a schematic cross-sectional view showing a second embodiment of the present invention. [Figure 8] FIG. 11 is a perspective view showing another aspect of the second embodiment of the present invention. [Figure 9] FIG. 9 is a schematic enlarged cross-sectional view of a local portion of FIG. 8. [Figure 10] 9 is a schematic cross-sectional view showing an example of a cavity in another embodiment of the second embodiment shown in FIG. 8. FIG. [Figure 11] 9 is a schematic cross-sectional view showing an example of a cavity in another embodiment of the second embodiment shown in FIG. 8. FIG. [Figure 12] 9 is a schematic cross-sectional view showing an example of a cavity in another embodiment of the second embodiment shown in FIG. 8. FIG. [Figure 13] 9 is a schematic cross-sectional view showing an example of a cavity in another embodiment of the second embodiment shown in FIG. 8. FIG. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0013] Figures 1 and 2 show a first embodiment of an implant according to the present invention, which is an artificial tooth root A used in tooth regeneration surgery. The implant shown in these drawings includes an outer surface 10 and a plurality of cavities 12, but can also optionally include a plurality of communicating passages 13.

[0014] A plurality of openings 11 are formed on the outer surface 10, and the plurality of cavities 12 are respectively connected to these openings 11. In this embodiment, the cavities 12 are connected to the openings 11 through a communication passage 13, and one end of the communication passage 13 is connected to the openings 11 and the other end is connected to the cavities 12. In this embodiment, one opening 11 is connected to one cavity 12 through one communication passage 13, but in other embodiments, a plurality of openings 11 may be connected to one cavity 12. FIG. 2 shows an arrangement state of the cavities 12, and in this drawing, the openings 11 and the cavities 12 are aligned on the outer surface 10, but in other embodiments, they may be irregularly arranged. Furthermore, FIG. 3 shows another embodiment of the cavities 12, and in this drawing, there is no communication passage, and the cavities 12 are directly connected to the openings 11.

[0015] The cavity 12 may have a circular, elliptical, egg-shaped or triangular cross-sectional shape in a direction perpendicular to the outer surface 10, while the maximum cross-sectional area of ​​the cavity 12 in a direction parallel to the outer surface 10 is larger than the cross-sectional area of ​​the opening 11, and such a structure can increase the space for storing the drug in the cavity 12. The surface of each cavity 12 may be smooth or uneven.

[0016] 4 and 5 show the cavity 12 having a triangular cross-sectional shape, and the cross-sectional area of ​​the cavity 12 in this embodiment increases with increasing distance from the outer surface 10. Furthermore, according to Fig. 5, the cavity 12 in this embodiment may directly communicate with the opening 11 without providing a communication passage.

[0017] 6 and 7 show a second embodiment of the implant according to the present invention, and the implant of this embodiment is a vascular stent B used in cardiac catheterization. The implant as the vascular stent B shown in these drawings has an approximately tubular outer shape, and has an outer peripheral wall surface and an inner peripheral wall surface on its outer surface 10. In this embodiment, the vascular stent B has openings 11 and cavities 12 formed on both the outer peripheral wall surface and the inner peripheral wall surface, but in other embodiments, the openings 11 and cavities 12 may be formed only on the outer peripheral wall surface.

[0018] 8 and 9 show another embodiment of the implant as the vascular stent B' of the second embodiment, in which FIG. 8 shows one of the multiple strip structures 101 constituting a mesh tube, and FIG. 9 shows a local enlarged cross-sectional view of the strip structure 101. According to these drawings, multiple tubes 102 are densely formed on each strip structure 101 of the vascular stent B', and the multiple tubes 102 in this embodiment are densely arranged so that the ends of each tube 102 connected to the strip structure 101 are adjacent to each other. To explain the structure of the tube 102 in detail, a cavity 12 is formed inside the tube 102, one end of each tube 102 is connected to the strip structure 101, and the other end is a free end having an opening 11, and the opening 11 is connected to the cavity 12. Furthermore, since the tubes 102 are densely arranged on the strip structure 101, the end surface of the free end of each tube 102 is configured as the outer surface 10 of the vascular stent B'.

[0019] Figures 10 to 13 show other embodiments of the cavity 12 of the tube 102. According to these drawings, the cavity 12 is formed at the end of the free end of each tube 102, and the cross-sectional shape in a direction perpendicular to the outer surface 10 may be circular, elliptical, egg-shaped or triangular. Meanwhile, it is preferable that the maximum cross-sectional area of ​​the cavity 12 in the direction parallel to the outer surface 10 is larger than the cross-sectional area of ​​the opening 11. The surface of each cavity 12 may be a smooth surface or an uneven surface.

[0020] 10 and 12, the cavity 12 communicates with the opening 11 through the communication passage 13. Specifically, one end of the communication passage 13 communicates with the opening 11 and the other end communicates with the cavity 12, and in these embodiments, the one opening 11 communicates with the one cavity 12 through the one communication passage 13. Also, in the embodiment shown in Fig. 11 and 13, there is no communication passage, and the cavity 12 communicates directly with the opening 11.

[0021] As described above, the implant of the present invention has a plurality of openings 11 formed on its outer surface 10, which communicate with the cavity 12. By applying a drug to the outer surface 10 of the implant, the cavity 12 can be filled with the drug. Furthermore, since the maximum cross-sectional area of ​​the cavity 12 is larger than the cross-sectional area of ​​the openings 11, the drug filled in the cavity 12 does not immediately flow out of the openings 11, but is stored in the cavity 12 and released slowly. When the implant of the present invention is applied to an artificial tooth root A, if a drug containing a component that promotes the proliferation rate of bone cells is filled in the cavity 12, the proliferation rate of bone cells in the alveolar bone can be improved, and the time required for the artificial tooth root A to be fixed and bonded to the alveolar bone can be shortened. On the other hand, when the implant of the present invention is applied to a vascular stent B, if a drug containing a component that suppresses the proliferation rate of biological tissue is filled in the cavity 12, clogging of the vascular stent B due to aggregation in the blood vessels can be suppressed, and restenosis of the blood vessel after surgery can be prevented. [Explanation of symbols]

[0022] 10 Outer surface 11 Opening 12 Cavity 13 Communication path 101 Strip structure 102 Body A. Artificial root B, B' Vascular stent

Claims

1. 1. An implant for use as a vascular stent, comprising: A plurality of strip structures each formed in a long and thin rod shape, the strip structures constituting a mesh-like tube; a plurality of tubes formed on the strip structure; The implant is characterized in that one end of each of the tubular bodies is connected to the strip structure and the other end is a free end having an opening, a cavity is formed inside each of the tubular bodies, the cavity is in communication with the opening, and an outer surface is formed at the end of the free end of each of the tubular bodies.

2. 2. The implant of claim 1, wherein the maximum cross-sectional area of ​​the cavity is greater than the cross-sectional area of ​​the opening.

3. 2. The implant according to claim 1, wherein the implant includes a plurality of communication passages, each of which has one end communicating with the opening and the other end communicating with the cavity.

4. 4. The implant according to claim 1, wherein the longitudinal cross-sectional shape of the cavity is circular, elliptical, egg-shaped or triangular.

5. 4. The implant according to claim 1, wherein a cross section of the cavity is parallel to the outer surface and the cross-sectional area increases with increasing distance from the outer surface.

Citation Information

Patent Citations

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