Tool set for manufacturing an adhesive patch, method for manufacturing an adhesive patch, and adhesive laminate

Abstract

A tool set (30) for manufacturing an adhesive patch (84) by processing a laminate web (80) is provided. The tool set (30) includes a cutting tool (51) having a cutting surface (52) in a cutting plane and an embossing tool having a pressing surface (37) in a pressing plane, the cutting plane and the pressing plane being parallel. The embossing tool (31) is configured to press an edge region (104) of the adhesive patch (84) to be manufactured, and the cutting tool (51) is configured to cut the adhesive patch (84) by cutting within or outside the edge region (104). A method for manufacturing an adhesive patch is also provided. This method essentially includes a feeding step, a pressing step, and a cutting step. Finally, an adhesive laminate (100) is provided having a backing layer (83) and an adhesive matrix layer. The backing layer (83) is larger in size than the adhesive matrix layer.

Description

[Technical field]

[0001] The present invention relates to an adhesive laminate, in particular a transdermal adhesive laminate.Furthermore, the present invention relates to an adhesive patch intermediate product, in particular a transdermal patch intermediate product, and to an adhesive patch product, in particular a transdermal patch, comprising such an adhesive laminate.Furthermore, the present invention relates to a tool set for producing an adhesive patch, in particular a transdermal patch.Finally, the present invention relates to a method for producing an adhesive patch, in particular a transdermal patch. [Background technology]

[0002] A common area of ​​application for adhesive laminates is in the field of adhesive patches, in particular transdermal patches, which are medicinal adhesive patches that are placed on the skin to administer specific amounts of drug onto the skin and / or through the skin into the bloodstream.

[0003] Such transdermal patches typically comprise at least a backing layer with an adhesive matrix in which the drug is disposed, the adhesive matrix allowing the transdermal patch to adhere to the skin, and the backing layer serving to protect the transdermal patch from the external environment. Summary of the Invention [Problem to be solved by the invention]

[0004] Adhesive patches, especially transdermal patches, present several problems.

[0005] One of the main problems that arise when applying such patches is that exposed and / or protruding adhesive matrix material comes into contact with the environment. In particular, the adhesive matrix material often comes into contact with objects, especially the user's clothing. On the one hand, this can lead to the objects, especially the clothing, becoming soiled and especially sticking. On the other hand, the patch can adhere to the object via the exposed adhesive matrix material. In this case, for example, if the object moves, the patch can slip off or come off from the skin.

[0006] Another problem is that the adhesive matrix itself is exposed and, in particular, the drug component is exposed to environmental stresses, which may affect the active ingredient. Furthermore, at least a portion of the adhesive matrix may detach from the patch, which may lead to inaccurate and / or failed drug administration.

[0007] It is an object of the present invention to provide an adhesive laminate, in particular a transdermal adhesive laminate, which prevents exposure of the adhesive matrix to the environment. It is a further object of the present invention to provide a method for producing an adhesive patch, in particular a transdermal patch, which prevents exposure of the adhesive matrix to the environment. In addition, it is an object of the present invention to provide a tool set for producing an adhesive patch, in particular a transdermal patch, which prevents exposure of the adhesive matrix to the environment. [Means for solving the problem]

[0008] These objects are achieved by an adhesive laminate as defined in claim 9, a method as defined in claim 6 and a tool set as defined in claim 1.

[0009] The adhesive laminate according to the present invention is in particular a transdermal adhesive laminate. The adhesive laminate comprises a backing layer and an adhesive matrix layer, the adhesive matrix layer being arranged on one side of the backing layer. In particular, the adhesive matrix layer is arranged on the bottom side of the backing layer. For this reason, it is preferred that the backing layer is the top layer and the adhesive matrix layer is the bottom layer of the adhesive laminate. The adhesive matrix layer comprises an adhesive matrix material. The adhesive matrix material preferably comprises an adhesive material and / or an active ingredient, such as a drug or a drug composition. The backing layer has a larger size, in particular a larger dimension, more particularly a larger perimeter, than the adhesive matrix layer. In other words, it is preferred that the backing layer is only partially covered by the adhesive matrix layer. For example, the edge areas of the backing layer are not covered by the adhesive matrix layer. However, it is still possible that the areas of the backing layer not covered by the adhesive matrix layer comprise adhesive matrix material, but it is preferred that this area comprises less, in particular significantly less, adhesive matrix material than the adhesive matrix layer. The adhesive layer may have an essentially rectangular or elliptical shape, in particular a circular or oval shape, and it is preferred that the backing layer and / or the adhesive matrix layer have such a shape. It is preferred that embossed shapes with sharp edges should be avoided.

[0010] The width of the adhesive matrix layer is, for example, in the range between 30 mm and 75 mm, in particular 50 mm. The height or thickness of the adhesive matrix layer is, for example, in the range between 100 micrometers and 500 micrometers. The breaking elongation of the adhesive matrix layer 82 is, for example, greater than 50%, for example in the range between 50% and 100%. The elastic modulus of the adhesive matrix layer is, for example, less than 30 Newtons per square millimeter.

[0011] The backing layer can include or consist of polyethylene terephthalate (PET). The height or thickness of the backing layer is, for example, 23 micrometers. The tear strength of the backing layer is, for example, 50 Newtons per centimeter. The tear strength, which is the length-related force at which tearing begins, is preferably in the range between 100 Newtons per centimeter and 140 Newtons per centimeter. The elongation at break is, for example, in the range between 80% and 120%.

[0012] In a preferred embodiment, the backing layer overlaps the adhesive matrix layer, in particular the backing layer completely overlaps the adhesive matrix layer.

[0013] The overlap region of the backing layer is preferably an edge region of the backing layer. The edge region, in particular the entire edge region, is in contact with, in particular significantly less adhesive matrix material than the remainder of the backing layer or is in contact with no adhesive matrix material. The adhesive matrix material of the edge region of the adhesive matrix layer is extruded from the edge region, so that preferably no adhesive matrix material or only a small portion of adhesive matrix material remains in the edge region. In particular, the edge region is the outer edge of the backing layer. The overlap region and / or the edge region overlaps, in particular, with the adhesive matrix by about 0.3 mm to 1.3 mm, more particularly by 0.5 mm.

[0014] In a preferred embodiment, the overlapping area covers the periphery of the adhesive matrix layer. In other words, the overlapping area of ​​the backing layer preferably surrounds the outside of the adhesive matrix layer at the periphery. Additionally or alternatively, the overlapping area is bent or folded around the adhesive matrix layer, in particular around the periphery of the adhesive matrix layer. The periphery is preferably the outer periphery of the adhesive matrix layer. In this context, the periphery may be understood as a contour.

[0015] In particular, the overlap region of the backing layer, in particular the region of the adhesive laminate in the edge region, and / or the overlap region of the backing layer, in particular the edge region, have an embossed or pressed portion. The overlap region is therefore preferably embossed or pressed. The embossed portion may optionally be defined as a pressed portion. This embossed portion is preferably formed by embossing or pressing, in particular pressing, the adhesive laminate in the overlap region. It is therefore preferred that the adhesive matrix material of the adhesive matrix layer is compressed and / or extruded in the overlap region. In particular, the embossed portion forms a wrap and / or a bend of the backing layer around the adhesive matrix layer. In other words, it is preferred that the edge region of the adhesive laminate is compressed and / or embossed.

[0016] In a preferred embodiment, the adhesive laminate has the shape of a final adhesive patch for medical applications, in particular a transdermal patch. The shape of the adhesive patch for medical applications is preferably obtained by cutting a laminate web formed of the adhesive laminate. In particular, cutting is performed in the overlapping area or outside the overlapping area, preferably at the periphery of the overlapping area. It is therefore preferred that this adhesive laminate has the shape of a transdermal patch, and that the edge area and / or the periphery of the adhesive laminate is embossed. In particular, the adhesive laminate thus defined is a cut-out and / or punched part of a laminate web formed of the adhesive laminate. In other words, the adhesive laminate thus defined is a specially shaped adhesive laminate cut and / or punched from a larger (identical) adhesive laminate. The adhesive laminate in the shape of a final adhesive patch is referred to throughout this specification as a final adhesive patch or adhesive patch.

[0017] The advantage of the adhesive laminate according to the invention is, on the one hand, that the adhesive laminate has a perimeter and / or edge area which is free of adhesive matrix material or contains only a significantly reduced amount of adhesive matrix material. On the other hand, by providing a covered edge area, the adhesive matrix material is protected from the environment. Thus, exposure to the environment is minimized. For example, the risk of the adhesive matrix material adhering to clothing etc. is thus prevented.

[0018] Another disclosed invention is an adhesive patch intermediate product, in particular a transdermal patch intermediate product. The intermediate product corresponds in particular to a product that is the basis for producing a final adhesive patch. The adhesive patch intermediate product is, for example, an intermediate product with a plurality of adhesive patches that can be separated to have individual adhesive patches, and / or an intermediate product in a pre-packaged state. This adhesive patch intermediate product comprises at least one, in particular a plurality of adhesive laminates having one or more characteristics of an adhesive laminate as defined above. The adhesive laminate or laminates preferably have the shape and / or dimensions of a final adhesive patch, in particular a transdermal patch. Furthermore, the adhesive patch intermediate product comprises a support layer. In particular the support layer is continuous. For example, the support layer may be a web, preferably a roll web. At least one, in particular a plurality of adhesive laminates are arranged on the support layer. The adhesive laminate or laminates of the shape and / or dimensions of a final adhesive patch, in particular a transdermal patch, are preferably arranged on a support layer. The adhesive matrix of the adhesive laminate or laminates is arranged between the support layer and the backing layer of the adhesive laminate or laminates. For example, the intermediate product comprises as basic material a laminate web having an adhesive laminate with a backing layer and a matrix layer and a support layer, the adhesive laminate having in particular a specific shape, more particularly the shape of the final adhesive patch, whereas the support layer is preferably in its original continuous shape which can also be found on the laminate web.

[0019] The height or thickness of the support layer is in particular in the range between 75 and 100 micrometers. The width of the support layer is, for example, 75 millimeters. The support layer preferably comprises or consists of polyethylene terephthalate (PET). The support layer has, for example, dehesive properties, in particular is covered with a dehesive coating.

[0020] Additionally, it is preferred that the adhesive patch intermediate product comprises a trellis of adhesive laminate, in particular said trellis being the scraps remaining when cutting and / or punching the final adhesive patches from the adhesive laminate, in particular the laminate web.

[0021] The overlapping areas, especially the edge areas, are preferably in loose contact with the support layer. Loose contact is defined as a detachable, especially peelable, contact of the overlapping areas with the support layer. In the production of adhesive patches, a number of adhesive laminates can be arranged on the support layer. In a next step, these adhesive laminates can be separated from the support layer and transferred to the next. In particular, the adhesive laminates can be transferred and / or packaged individually in a release liner. In this way, the support layer corresponds to a kind of intermediate carrier or intermediate conveyor or the like. It is therefore necessary that the adhesive laminates, especially the overlapping areas, can be easily separated from the support layer. The connection between the overlapping areas and the support layer is therefore made simply by pressure connection and / or connection via a thin layer of adhesive matrix material.

[0022] Another disclosed invention is an adhesive patch product, preferably a transdermal patch product. The adhesive patch product comprises in particular an adhesive laminate having one or more features of the adhesive laminate as defined above. The adhesive patch product preferably corresponds to a final adhesive patch product, for example sold individually or in a package. The adhesive laminate of the adhesive patch product preferably has the shape and / or dimensions of the final adhesive patch product. Furthermore, the adhesive patch product comprises a release liner. The release liner is in particular a release liner that is separable, in particular a peelable release liner, from the adhesive laminate before application. The release liner is preferably a liner that is separated, in particular peeled, before applying the adhesive patch to the skin of the user. In particular, the shape and / or dimensions of the release liner are the same as the shape and / or dimensions of the adhesive laminate. More particularly, the size of the release liner is larger than the size of the adhesive laminate. The release liner may be tearable and / or may have non-adhesive areas to allow easier removal. The adhesive matrix of the adhesive laminate is arranged between the release liner and the backing layer of the adhesive laminate.

[0023] The overlapping regions, especially the edge regions, are preferably in loose contact with the release liner, preferably defined as loose contact having one or more of the loose contact characteristics described above in connection with the adhesive patch intermediate product.

[0024] In a preferred embodiment, the adhesive patch product comprises a package having in particular a bottom pouch layer and a top pouch layer, which are in particular joined, more particularly circumferentially sealed, to form a closed pouch package.

[0025] Another disclosed invention is a tool set for producing an adhesive patch, in particular a transdermal patch, preferably by processing a laminate web. The laminate web preferably comprises an adhesive laminate having one or more features of the adhesive laminate as defined above. The tool set comprises a cutting tool having a cutting surface in the cutting plane. The cutting surface is in particular a cutting blade, more in particular a thin cutting blade. Furthermore, the tool set comprises an embossing tool having a pressing surface in the pressing plane. The pressing surface is in particular a pressing surface, more in particular a flat pressing surface. In other words, the pressing surface has in particular the shape and / or cross section of a hollow cylinder, more in particular the shape and / or cross section of a circular hollow cylinder. Alternatively, the embossing tool may be further defined as a pressing tool. The cutting plane and the pressing plane are parallel to each other. The embossing tool is configured to press, in particular press, an edge area that may be further defined as the periphery of the adhesive patch to be produced. The embossing tool is therefore configured to compress the contour or perimeter of the adhesive patch to be produced, for example, onto the laminate web. For example, the embossing tool comprises an embossing die or an embossing die head, in particular an embossing die or an embossing die head. The embossing is preferably performed by strokes. However, the embossing tool may also comprise, for example, an embossing roll or may consist of, for example, an embossing roll or the like. In particular, the width of the pressing surface is in the range of about 0.3 mm to 1.25 mm, more particularly 0.5 mm. In addition, the cutting tool is configured to cut out the adhesive patch to be produced, in particular by cutting in the edge region or outside the edge region, preferably at the perimeter of the edge region. Thus, for example, the cutting tool has a cutting perimeter that is larger than the embossing perimeter of the embossing tool. These perimeters are in particular the inner perimeter. The cutting is preferably performed on the laminate web. The cutting tool is in particular a punching tool, more particularly operating in a stroke manner. In addition, however, the cutting tool can also comprise or consist of, for example, a cutting roll or the like.

[0026] In a preferred embodiment, the cutting tool and the embossing tool are coaxially movable, in particular in a stroke manner. The cutting surface is preferably arranged circumferentially with respect to the pressing surface. In other words, the cutting surface preferably surrounds the pressing surface. Such an arrangement is for example realized by arranging the embossing tool within the cutting tool. The cutting tool is preferably arranged close to the outer periphery of the embossing tool. Thus, the cut can be made at the outer periphery of the compressed edge region.

[0027] In a preferred embodiment, the cutting surface and / or the pressing surface has a ring shape, in particular a circular or rectangular ring shape. In particular, the ring may have a circular, oval or square shape. It is therefore preferred that the cutting tool and / or the embossing tool are symmetrical, more particularly rotationally symmetrical.

[0028] In particular, the cutting tool and the embossing tool are coaxially movable relative to each other. Thus, for example, cutting and embossing can be performed separately during the individual movements of the embossing tool and the cutting tool. For example, embossing can be performed first and cutting can be performed after embossing or during continuous embossing. Alternatively, the cutting tool and the embossing tool are fixed relative to each other. Considering such a configuration, cutting and embossing can be performed by moving the cutting tool and the embossing tool together.

[0029] In a preferred embodiment, the cutting and / or pressing surface is offset in the cutting position relative to the base surface, preferably at a recessed height in the maximum stroke offset position. The base surface is in particular the surface on which the laminate web and / or the support layer and the laminate web are placed. Thus, when the laminate to be processed is placed on the base surface, the cutting and / or pressing surface does not reach the base surface, thus preventing a complete cutting and / or pressing of the entire laminate web. It is thus possible, for example, to cut and / or press only certain parts and / or layers of the laminate web. In particular, it is preferred to cut only through the backing layer and preferably the adhesive matrix. Thus, more particularly, the cutting is preferably performed by cutting all the way to the support layer, without cutting into and / or damaging the support layer.

[0030] In particular, the cutting surface is offset to a protruding height relative to the pressing surface at least in the cutting position, preferably in the position of maximum stroke deviation. With such an arrangement, the cutting surface can, for example, penetrate deeper into the laminate compared to the pressing surface. The height of the cutting surface offset relative to the pressing surface preferably corresponds to the height of the backing layer of the laminate web. It is thus possible to cut the backing layer only, in particular in or around the area compressed by the pressing surface, preferably such that no adhesive matrix material of the laminate web remains or only residual parts of the adhesive matrix material of the laminate web remain. If the cutting tool and the embossing tool are fixed to one another, it is preferred that the cutting surface projects in the cutting direction relative to the embossing surface. In other words, the cutting plane is offset positively relative to the pressing plane. If the cutting tool and the embossing tool are coaxially movable, the cutting surface is provided to project beyond the pressing surface to the position of maximum deviation and / or maximum stroke of the cutting surface and the pressing surface.

[0031] The inner edge of the cutting surface and the outer edge of the pressing surface preferably have essentially the same dimensions, in particular the same diameter, e.g., if the cutting surface and the pressing surface are arranged coaxially, in particular if the cutting surface surrounds the pressing surface, the cut is made adjacent to the pressing surface and thus adjacent to the compression zone.

[0032] More specifically, each dimension of the pressing surface is in the range between 80% and about 100% of the internal dimension of the cutting surface, the dimension being preferably a diameter. For example, the internal dimension of the cutting surface is essentially the same as the external dimension of the cutting surface, so that the cutting surface is preferably a thin blade. In particular, the external dimension of the pressing surface is essentially the same as the internal dimension of the cutting surface, so that the cutting surface preferably closely surrounds the pressing surface. Alternatively, the external dimension of the pressing surface is in the range between about 95% and 99%, more particularly 97%, of the internal dimension of the cutting surface. The internal dimension of the pressing surface is in particular in the range between about 80% and 98%, more particularly 92%, of the internal dimension of the cutting surface. The cutting surface is preferably a cutting blade having an internal dimension that essentially corresponds to the external dimension. In particular, if the cutting blade is circular, the cutting blade preferably has a diameter of 19.1 mm. The pressing surface preferably has the shape and / or cross section of a hollow cylinder. In particular, the hollow cylinder has an inner diameter of 17.6 mm and an outer diameter of 18.6 mm, so that the pressing surface has a width of 0.5 mm.

[0033] Another disclosed invention is an apparatus for manufacturing adhesive patches, in particular transdermal patches. The apparatus is preferably for processing a laminate web. The apparatus comprises a tool set having one or more of the features of the tool set described above. The apparatus further comprises a drive for actuating the tool set. The drive preferably comprises a spring assembly with at least one spring, in particular a Belleville spring. For pressing and / or punching, the drive preferably actuates the tool set, in particular the embossing tool and / or the cutting tool, in a stroke manner.

[0034] In a preferred embodiment, the manufacturing apparatus further comprises a carrier plate, in particular the embossing tool and / or the cutting tool are connected to the carrier plate, more particularly integrally connected, for example the cutting tool is formed integrally with the carrier plate and the embossing tool moves coaxially with respect to the cutting tool.

[0035] Another disclosed invention is an adhesive patch manufacturing system, in particular a transdermal patch manufacturing system. The manufacturing system is preferably a manufacturing system for processing a laminated web. In a preferred embodiment, the manufacturing system comprises a conveying device. The conveying device conveys the laminated web and / or adhesive patch to be manufactured through the manufacturing system. Alternatively or additionally, the conveying device feeds the material to be processed, e.g. the laminated web, to the manufacturing system. Alternatively or additionally, the conveying device discharges the material from the manufacturing system and / or transfers the final patch and / or intermediate patch to a further processing stage. In particular, the conveying device comprises one or more of motorized rolls, transport belts, discontinuous conveyors, etc.

[0036] Another disclosed invention is a method for producing an adhesive patch, in particular a transdermal patch. The method is preferably carried out using a tool set and / or a manufacturing device having one or more of the features of the tool set and / or manufacturing device as described above. In one step of the method, a laminated web having a backing layer, a support layer and an adhesive matrix layer arranged between the backing layer and the support layer is provided as input material. In another step, in particular a subsequent step, an edge region of the adhesive patch to be produced is pressed, in particular embossed, onto the backing layer of the laminated web. In other words, in this step, a compressed contour or perimeter region of the adhesive patch to be produced is formed. During the pressing step, the adhesive matrix material of the adhesive matrix layer arranged below the edge region is extruded from the edge region. In particular, most or all of the adhesive matrix material is extruded from the edge region, leaving no or significantly less adhesive matrix material. In addition to or instead of extruding the adhesive matrix material, in the pressing step, the edge region of the backing layer is bent and / or folded around the adhesive matrix layer. Thus, it is possible to cover the adhesive matrix layer with a backing layer around its periphery. In addition, the method comprises a further, in particular a subsequent, step of cutting out, in particular punching out, the adhesive patch to be produced. The cutting is carried out, in particular in the backing layer, in the edge region or outside the edge region, preferably at the periphery of the edge region. Thus, after the cutting step, it is possible to obtain a remaining adhesive patch with a compressed edge region and / or a covering of the adhesive matrix layer that is free or almost free of adhesive matrix material. In addition, it is preferred that after cutting, a trellis formed by the backing layer remains.

[0037] It is preferred that the pressing step is performed before the cutting step. In addition, the pressing and cutting steps can be performed simultaneously or in any kind of setup for the transfer step to meet the needs of the product. It is especially preferred to perform the pressing step first and cut during pressing. This process allows for optimal results when performing uniform pressing and / or clean and efficient cutting.

[0038] Preferably, after the cutting step an intermediate adhesive patch product remains, said intermediate adhesive patch product in particular comprising an adhesive laminate cut to the shape of the final adhesive patch and having pressed edge regions, said intermediate adhesive patch product further comprising a support layer and optionally a trellis.

[0039] In a preferred embodiment, the cutting and / or pressing steps are performed in a stroke manner, in particular by means of a stroke device.

[0040] More specifically, pressing and cutting are performed in the same area, e.g., in the same position or location, preferably coaxially. For example, the stroke device for cutting and the stroke device for pressing move coaxially, preferably the stroke device for cutting moves around the stroke device for pressing. Thus, pressing and cutting can be performed in the same location and / or simultaneously.

[0041] The cut is preferably made by cutting down to the support layer of the laminated web to be processed, preferably without cutting through the support layer. It is therefore possible to produce several patches on one support layer, in particular having a backing layer and an adhesive matrix layer. For example, the patch can be separated from the support layer, since the support layer can be used as a carrier.

[0042] In a preferred additional, in particular subsequent step, the support layer and / or the trellis are separated and / or removed. Separation is preferably effected in particular by peeling the support layer and / or the trellis from the remainder of the laminate. In particular the support layer is separated from the adhesive laminate having the cut-out shape and from the trellis. The areas of the backing layer of the adhesive laminate which are in contact with the support layer by pressing are non-destructively separated in particular from the backing layer and / or the support layer. Said non-destructive separation is possible in particular due to loose connections formed during pressing. The trellis is preferably likewise non-destructively separated from the support layer.

[0043] In an additional optional step, the cut and pressed adhesive patch is transferred to, in particular onto, a release liner, in particular a peelable release liner that can be separated from the adhesive patch before application. In order to transfer the adhesive patch to the release liner, in particular during separation of the support layer, it is preferred that the adhesive patch is transferred directly from the support layer to the release liner, for example in the area where the support layer and the release liner run on separate rolls next to each other.

[0044] In a preferred embodiment, an additional, preferably subsequent step is to package the adhesive patch having the shaped adhesive laminate and release liner, in particular by covering both sides of the adhesive patch with a pouch material, the final product of the step providing a particularly packaged primary adhesive patch.

[0045] The features described above with respect to different inventions can be applied to each other and / or combined. In addition, the features of the following figures and corresponding description can be applied to different inventions and / or combined individually or together.

[0046] The invention will now be described in more detail below by way of preferred embodiments with reference to the accompanying drawings, in which: FIG. [Brief description of the drawings]

[0047] [Figure 1] 1 is a schematic diagram showing an embodiment of a pressure-sensitive adhesive laminate according to the present invention. [Figure 2a] FIG. 1 is a schematic diagram showing a method for producing an adhesive patch according to the present invention. [Figure 2b] FIG. 1 is a schematic diagram showing a method for producing an adhesive patch according to the present invention. [Figure 2c] FIG. 1 is a schematic diagram showing a method for producing an adhesive patch according to the present invention. [Diagram 3] 1 is a schematic diagram showing an embodiment of an adhesive patch intermediate product according to the present invention. [Figure 4] 1 is a schematic diagram illustrating an embodiment of an adhesive patch product according to the present invention. [Diagram 5]1 is a schematic diagram illustrating an embodiment of an adhesive patch manufacturing system according to the present invention. [Figure 6] 1 is a diagram showing an embodiment of an adhesive patch manufacturing apparatus according to the present invention; [Figure 7] 1A and 1B are diagrams showing an embodiment of a cutting tool according to the present invention; [Figure 8] 1 shows an embodiment of an embossing tool according to the present invention; [Figure 9] FIG. 1 shows an embodiment of a tool set according to the invention in a first position. [Figure 10] FIG. 2 shows an embodiment of a tool set according to the present invention in a second position. [Figure 11] FIG. 2 shows an embodiment of a tool set according to the invention in a third position. [Figure 12] FIG. 12 is a detailed view of FIG. [Figure 13] 1 is a diagram showing an embodiment of a tool set according to the present invention; DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0048] FIG. 1 shows an adhesive laminate, in particular a transdermal adhesive laminate 100 .

[0049] The adhesive laminate 100 comprises a backing layer 83 and an adhesive matrix layer 82. The adhesive matrix layer 82 comprises an adhesive matrix material 89. The backing layer 83 has a larger size, in particular a larger perimeter, than the adhesive matrix layer 82, and an edge region 104 of an overlap region 102 of the adhesive laminate 100 and / or the backing layer 83 overlaps the adhesive matrix layer 82. The edge region 104 has a bent portion 106 that wraps around the adhesive matrix layer 82, in particular the perimeter of the adhesive matrix layer 82.

[0050] The overlap region 102 includes a compressed or embossed region 88, synonymously a pressed pressure zone 88 (see, for example, Figures 2a-2c), such that the pressure zone 88 is free of adhesive matrix material or contains significantly less adhesive matrix material.

[0051] The adhesive laminate 100 of Figure 1 has the shape of the final adhesive patch 84. The adhesive laminate thus corresponds to the adhesive patch.

[0052] 2a-2c show diagrammatically a method for manufacturing an adhesive patch 108, in particular a transdermal patch.

[0053] Figure 2a shows a laminate web 80 as a base material for producing an adhesive patch. In particular, the laminate web 80 is continuous, only a fragment of which is shown in the drawing. A support layer 81 is connected to an adhesive matrix layer 82. In particular, the laminate web 80 is placed on a base surface (not identified by a reference number). The laminate web 80 comprises an adhesive laminate 100 (substantially according to Figure 1) and a support layer 81.

[0054] Figure 2b shows diagrammatically the pressing step using an embossing tool 31, represented by two arrows 31. The laminate web 80 is embossed by the embossing tool 31 which forms pressure zones 88 in the edge regions (see further Figures 1 and 12 and the corresponding description).

[0055] Figure 2c shows diagrammatically the cutting step after the pressing step, using a cutting tool 51 represented by two arrows 51. The laminate web 80 is cut by the cutting tool 51 to form cutting notches 110. The cut is only made down to the support layer 81 in order not to damage it (see further Figure 12 and the corresponding description).

[0056] After the cutting process, what remains is an adhesive patch intermediate product 108 having cut-out portions 84 of laminate web 80, an intact support layer 81, and a trellis 85 including remnants 85', 85''. The support layer 81, which is connected to the trellis 85 herein, is not part of the trellis, but is part of the intermediate product 108. The trellis 85 simply comprises remnants of the backing layer 83 and adhesive matrix layer 82.

[0057] The cut-out portion 84 of the adhesive patch intermediate product 108 has the shape of the final adhesive patch.

[0058] 3 shows diagrammatically an adhesive patch intermediate product 108 having a pressed and cut adhesive laminate 100. Thus, the adhesive patch intermediate product 108 comprises an adhesive patch 84 having an embossed edge region 104 and separated from the remainder of the adhesive laminate 100, i.e., trellis 85, by a tear line 110. The trellis 85 and adhesive patch 84 are disposed on a support layer 18 (not shown) of the adhesive laminate 100.

[0059] Figure 4 shows diagrammatically an adhesive laminate 100 in the form of an adhesive patch product 112. The adhesive patch product 112 comprises one adhesive patch 84, which substantially corresponds to the adhesive patch 84 of Figure 1. The adhesive patch 84 is particularly loosely, more particularly releasably connected to a release liner 86. In particular, the size of the release liner 86 is similar to the size of the adhesive patch 84, in contrast to a continuous support layer 81 (see e.g. Figure 2c). An adhesive matrix layer 82 is disposed between the release liner 86 and the backing layer 81 of the adhesive laminate.

[0060] 4 further comprises a primary package 114. However, the adhesive patch 84 and associated release liner 86 together still comprise an adhesive patch product, such adhesive patch product being designated by reference numeral 112'.

[0061] The primary wrapper 114 has two layers, a top layer 116 and a bottom layer 118. The two layers 116, 118 are joined, and in particular sealed, by a joining portion 120. The primary wrapper preferably completely covers the adhesive patch 84 and the associated release liner 86. To this end, the primary wrapper preferably forms a pouch 114, for example a tear-open pouch.

[0062] 5 shows an adhesive patch production system 1. In particular, the adhesive patch production system 1 is a production system for processing a laminate web 80 comprising an adhesive laminate. The individual laminate webs 80 are unwound from a roll 2 and conveyed in a conveying direction 5 by a conveying device 6. The conveying device 6 is a discontinuous conveyor 6 which grips the material to be conveyed and conveys a given amount in the direction of a transfer station 8. After the gripping device 7, configured for example as tongs, is released, it returns to the starting position from which the next conveying cycle begins.

[0063] For example between the roll 2 and the conveyor 6 an adhesive patch manufacturing device 10 is arranged. This adhesive patch manufacturing device 10 is preferably a cutting and embossing device. In this adhesive patch manufacturing device 10 a multi-layered laminate web 80 is locally compressed and cut in specific areas, for example by a tool unit 15. The tool unit 15 shown in FIG. 5 comprises a tool set 30, which comprises an embossing tool 31 and a cutting tool 51, see FIGS. 6 to 13. These tools 31, 51 each have a closed processing contour in a plane. In the subsequent peeling station 9 the area of ​​the laminate web 80 enclosed by the cutting tool 51 during the working stroke remains as an adhesive laminate 100 in the form of a final adhesive patch 84 on the support layer 81 of the laminate web 80, while the remaining trellis, in particular the surrounding punched out piece 85, is peeled off.

[0064] At the transfer station 8, the adhesive patch 84 is transferred from the support layer 81 onto a release liner 86 for transport, for example, to a further processing or packaging station.

[0065] 6 shows a manufacturing device 10. The manufacturing device comprises, for example, a press 12, which is fixed, for example, to a bed plate 11. The press 12 has a rigid press frame 13, in which a counter pressure plate 14, for example with a base plane parallel to the bed plate 11, is arranged. A tool unit 15 is also attached to the press frame 13. This tool unit 15 is movable relative to the press frame 13 in a direction perpendicular to the counter pressure plate 14 from a rest position 21 (see FIG. 9) to a working position 22 (see FIG. 11) and vice versa. The direction of movement of the tool unit 15 towards the counter pressure plate 14 is referred to in the following as the working stroke direction 23. The opposite direction, i.e. from the working position 22 to the rest position 21, is the return stroke direction 24.

[0066] In the press 12 it is possible to set the pressing stroke, the pressing force and the position of the tool set 30, which for example comprises one or more tools 31, 51 of the tool unit 15. For this purpose the press 12 has, for example, three, in particular manually settable setting screws 16. In the exemplary embodiment of Fig. 6 the tool set 30 is configured to be reusable. During the tool stroke a number of adhesive laminates 100 in the form of final adhesive patches 84 with compressed edge areas are produced simultaneously, in this case on the laminate web 80. However, the tool set 30 can also be configured for single use.

[0067] In Figures 5, 6 and 9 to 12, the laminate web 80 is placed on the counter pressure plate 14 and conveyed through the press 12 in the conveying direction 5. In this exemplary embodiment, the laminate web 80 is conveyed when the tool unit 15 is in the rest position 21. The tool set 30 is then placed above the laminate web 80. The entire tool unit 15 is actuable in the press 12 by means of a drive, for example by means of a pressure cylinder 17. Thus, in this exemplary embodiment, this pressure cylinder 17 actuates both the cutting tool 51 and the embossing tool 31.

[0068] FIG. 7 shows a cutting tool unit 50 in the form of a punch tool unit. The cutting tool unit comprises a carrier plate 53 and a cutting tool 51 in the form of an annular blade 51 inserted in the carrier plate 53. The carrier plate 53 is produced in the exemplary embodiment from an aluminum-magnesium alloy, for example AlMg4,5Mn with material number 3.3547. The carrier plate has a rectangular base area and a thickness of, for example, 8 millimeters. The carrier plate 53 has countersunk through holes 54 in the corner areas. Furthermore, recesses 56 are provided at the end sides 55. In the vertical central longitudinal section of the carrier plate 53, a tool opening 57 is provided with a circular cross section.

[0069] Into this tool opening 57, the annular blade 51 is fitted, for example by press-fitting. The annular blade is made of rolled steel strip and has a hardness of, for example, 66 HRC. If necessary, the cutting tool 51 is reinforced by a rear wall made of stainless steel. A butt joint 58 runs parallel to the central axis 59 of the annular blade 51. The annular blade 51 has a constant height in the circumferential direction perpendicular to the carrier plate 53. In an exemplary embodiment, the thickness of the annular blade is 0.5 millimeters. For example, the annular blade 51 projects downward from the carrier plate 53, i.e. in the working stroke direction 23, by one third of its height at the edge side 61.

[0070] The cutting tool 51 has a cutting surface 52. The cutting surface 52 is in particular a circumferential cutting edge, which is bounded, for example, by an inner side 62 and an outer side 63 (see FIG. 12). The cutting edge 52 lies in a cutting plane perpendicular to the working stroke direction 23. This plane is referred to below as the cutting plane. The cutting edge angle is, for example, 40 degrees. In this case, in FIGS. 7 and 12, the inner side 62 forms an angle of 30 degrees with the return stroke direction 24, which is opposite to the working stroke direction 23. The inner side 62 is therefore formed in the shape of a truncated cone. The imaginary conical tip lies on the central axis 59 of the cutting tool 51 and is offset in the return stroke direction 24 relative to the cutting edge 52. This inner side 62 is referred to below as the second working surface 62. The cutting edge 52 extends centrally with respect to the thickness of the annular blade 51. The outer side 63, which is referred to below as the third working surface 63, is likewise formed in the shape of a truncated cone. The imaginary conical tip of the associated cone is offset in the working stroke direction 23 relative to the cutting edge 52. The inner surface 64 of the annular blade 51 lies within the tolerance zone K7 according to ISO 286, for example around the nominal dimensions.

[0071] FIG. 8 shows the embossing tool 31. The embossing tool 31 is rotationally symmetrical with respect to a central axis 39 parallel to the working stroke direction 23. The embossing tool 31 is formed like a stamping die. The embossing tool 31 has an embossing plate 33 and a central guide rod 34 attached to the embossing plate. In an exemplary embodiment, the embossing tool 31 is made of austenitic steel, for example X5CrNi18-10 with material number 1.5301. A clearance fit is formed between the outer diameter of the embossing plate 33 and the inner diameter of the annular blade 51. The clearance is for example in the range between 0.4% and 1.2% of the nominal diameter of the pair consisting of the embossing tool 31 and the annular blade 51. The clearance of the pair is less than 2% of the nominal diameter of the pair. The nominal diameter of the pair is the nominal inner diameter of the annular blade 51.

[0072] The embossing plate 33 has a peripheral lip 35 in the circumferential direction facing away from the guide rod 34. This peripheral lip 35 is flush with a side surface 36 of the embossing tool 31. In the working stroke direction 23, an end face 37 adjoins the peripheral lip 35. This end face 37 is arranged perpendicular to the central axis 39 of the embossing tool 31. This end face is referred to below as the pressing face or, synonymously, as the first working face 37 and lies in the working face plane. In an exemplary embodiment, the thickness of the peripheral lip 35 is 2.6% of the diameter of the embossing plate 33. The height of the embossing plate 33 perpendicular to the plane of the first working face 37 is, for example, 7 times the thickness of the peripheral lip 35.

[0073] The peripheral lip 35 surrounds a receiving space 38. The receiving space has, for example, a mainly flat surface 41. The surface 41 is parallel to the first working surface 37 and is spaced from the first working surface 37 in the return stroke direction 24 by three times the thickness of the peripheral lip 35. The surface 41 may carry an inscription, for example the name of the tool. The interface between the side surface 36, the first working surface 37 and the receiving space 38 may be provided with a non-stick coating, for example a silicone hybrid polymer.

[0074] The guide rod 34, which is in particular formed integrally with the embossing plate 33, has a cylindrical shape. The diameter of the guide rod is, for example, 21% of the diameter of the embossing plate 33. In an exemplary embodiment, the length of the guide rod 34 is 55% of the diameter of the embossing plate 33. The guide rod 34 has a circumferential annular groove 42 at its end remote from the embossing plate 33. In the mounted state of the embossing tool 31, the guide rod 34 is guided, for example, in a sliding bush 44.

[0075] Figures 9-11 show the use of the tool set 30. These figures show cross-sectional views, the cross-section of which is perpendicular to the conveying direction 5 . In this case, in Figure 9, the tool set 30 is in the first rest position 21. In this rest position 21, both the cutting tool 51 and the embossing tool 31 are arranged at a distance from the laminate web 80. The embossing tool 31 and the annular blade 51 are arranged coaxially with each other in these figures. The contour of the cutting blade 52 of the cutting tool 51 matches the first working surface 37 of the embossing tool 31. The central axes 39, 59 of the two rotationally symmetrical tools 31, 51 lie on a common straight line. Each internal dimension of the first working surface 37 in the working surface plane lies in the range between 80% and 98% of the dimension of the cutting blade 52 in the cutting blade plane, parallel to the first working surface. If the tools 31, 51 are constructed in the form of a circular ring, these dimensions can be diameters. For example, the greater the ratio of the dimensions to one another, the less force must be applied to the first working surface 37 to reach the desired compression level. The ratio of the inner dimension of the first working surface 37 to the dimension of the first cutting blade 52 parallel to the first working surface can further be in the range between 83% and 98%. In an exemplary embodiment, the ratio of the inner diameter of the first working surface 37 to the diameter of the cutting blade 52 in the cutting plane is 95%. This ratio is in the range between 80% and 98%.

[0076] The width of the first working surface 37 in a plane perpendicular to the working stroke direction 23 corresponds, for example, to at least half the difference between the outer diameter of the third working surface 63 and the inner diameter of the second working surface 62. The width of the first working surface 37 is, for example, at least 0.3 mm and at most 1.25 mm, preferably 0.5 mm. In an exemplary embodiment, the width of the first working surface 37 corresponds to the thickness of the cutting tool 51.

[0077] The embossing tool 31 is supported on a sliding bush 44 by means of a support ring 43 inserted in the annular groove 42. This sliding bush 44 rests in a recess 45 of a support plate 46. The support plate 46 is supported on a carrier plate 53 and is, for example, screwed to the carrier plate. Between the support side 47 of the recess 45 facing the working stroke direction 23 and the embossing plate 33, a drive is arranged, for example in the form of a disk spring assembly 48, which in particular has four disk springs 49. These disk springs 49 are fitted on and guided on the guide rods 34. In FIG. 9, the disk spring assembly 48 is unloaded. The embossing tool 31 is therefore suspended on the support plate 46. In the rest position 21, the embossing tool 31 projects beyond the cutting edge 52 of the annular blade 51 in the working stroke direction 23.

[0078] The laminate web 80 is, for example, a composite material 80 formed from three layers. The bottom layer is a support layer 81 having a thickness in the range between 75 micrometers and 100 micrometers. The width in the cross-machine direction 4 transverse to the conveying direction 5 is, for example, 75 millimeters. In an exemplary embodiment, the support layer 81 is composed of polyethylene terephthalate (PET). The support layer has, for example, dehesive properties.

[0079] An adhesive matrix layer 82 is adhered to the support layer 81. The adhesive matrix layer 82 may further comprise an active substance. The width of the adhesive matrix layer 82 in the width direction 4 is, for example, two-thirds of the width of the support layer 81. The support layer 81 projects on both sides beyond the adhesive matrix layer 82, which is arranged symmetrically with respect to the vertical central longitudinal plane of the support layer. The thickness of the adhesive matrix layer 82 is, for example, in the range between 100 and 500 micrometers. The elongation at break of the adhesive matrix layer 82 is, for example, greater than 50%, for example in the range between 50% and 100%. The modulus of elasticity is, for example, less than 30 Newtons per square millimeter.

[0080] The adhesive matrix layer 82 is covered by a backing layer 83. The backing layer 83 may be made of the same material as the support layer 81. The thickness of the backing layer 83 is, for example, 23 micrometers. The tear strength of the backing layer is, for example, 50 Newtons per centimeter. The tear strength, which is the length-related force at the start of tearing, is in the range between 100 Newtons per centimeter and 140 Newtons per centimeter. The elongation at break is in the range between 80% and 120%. These values ​​correspond, for example, to those of the support layer 81. The backing layer 83 may have dehesive properties, at least on the side facing away from the adhesive matrix layer 82.

[0081] To form an embossed edge 87 in the laminate web 80, the tool unit 15 with the tool set 30 moves in the working stroke direction 23. The embossing tool 31 continues to protrude in the working stroke direction 23 beyond the cutting edge 52 of the annular blade 51. During this working stroke, the first working surface 37 comes into contact with the backing layer 83 of the laminate web 80, see FIG. 10. In this second momentary, e.g. temporary, intermediate position, the disc spring assembly 48 is not deformed. The annular blade 51 continues to be spaced apart from the laminate web 80.

[0082] During further movement of the tool unit 15 in the working stroke direction 23, the first working surface 37 remains on the backing layer 81. The disk spring assembly 48 is loaded such that the pressing force transmitted from the first working surface 37 to the backing layer 83 increases. The backing layer 83 locally deforms in the working stroke direction 23 and displaces the adhesive matrix material 89 within the adhesive matrix layer 82 during processing. The overlap region 102 has a pressure zone 88, for example in the form of a circular ring, in which the adhesive matrix material 89 displaces both to the inner region 91 and to the outer region 92 adjacent to the peripheral lip 35. The adhesive matrix material is extruded from the pressed edges.

[0083] As the tool unit 15 moves further in the working stroke direction 23, the force on the backing layer 83 increases in the area of ​​the peripheral lip 35. More adhesive matrix material 89 moves to the inner area 91 and to the outer area 92. The annular blade 51 moves along the embossing tool 31. It contacts the backing layer 83 and cuts it. The second working surface 62, due to its geometric configuration, transfers the adhesive matrix material 89 to the pressure zone 88 of the laminate web 80. If necessary, the adhesive matrix layer 82 can be solidified in this area.

[0084] The third working surface 63 similarly penetrates the laminate web 80. Due to the geometric configuration of this third working surface 63, the adhesive matrix material 89 migrates only slightly to the outer regions 92.

[0085] FIG. 11 shows the tool unit 15 in the third working position, which corresponds to the maximum stroke deflection position. FIG. 12 shows a detail of this FIG. 11 in the area of ​​the cutting blade 52. The embossing tool 31 presses and compresses the laminate web 80. The laminate web 80 bulges slightly in the area internally adjacent to the peripheral lip 35. The disk spring assembly 48 is deformed. The carrier plate 53 has moved in the working stroke direction 23 relative to the embossing tool 31. The guide rod 34 protrudes from the support plate 46. The support ring 43 is arranged at a distance from the sliding bush 44.

[0086] The annular blade 51 cuts the backing layer 83 and the adhesive matrix layer 82. In this working position 22, the cutting blade 52 is spaced from the counter pressure plate 14, i.e. the base surface, by at least the thickness of the support layer 81. The cutting blade 52 is in this case offset in the working stroke direction 23 relative to the first working surface 37. This offset is equal to or greater than the thickness of the backing layer 83. The position of the cutting blade 52 in the working position 22 can be controlled with respect to the path and / or pressure relative to the counter pressure plate 14. The laminate web 80 can bulge away from the annular blade 51.

[0087] The tool set 30 rises in the return stroke direction 24 from the working position 22. During the raising of the carrier plate 53, the annular blade 51 moves against the laminate web 80 and the still supported embossing tool 31. The disc spring assembly 48 is released from pressure.

[0088] During further lifting of the carrier plate 53, the annular blade 51 leaves completely the envelope contour of the laminate web 80. The embossing tool 31 also lifts off the laminate web 80. What remains on the support layer 81 is a disc-shaped adhesive laminate 100, in particular the adhesive patch 84, adjacent the embossed edge 87 and the punched out scrap 85, respectively.

[0089] The tool set 30 can further be configured such that the annular blade 51 and the embossing tool 31 are individually movable in the working stroke direction 23 and in the return stroke direction 24. Considering the coaxial arrangement of the two tools 31, 51, the two tools 31, 51 can be operated simultaneously or with a time shift with respect to each other. The press 12 has for this purpose, for example, two individually controllable pressure cylinders. The two pressure cylinders are controlled pneumatically, for example, via an electromagnetically actuated 5 / 2-way valve with a spring reset. For the return stroke, for example, it is possible to switch the pressure cylinder that controls the embossing tool 31 first of all. The embossing tool 31 releases its load on the laminate web 80. Then, using a multi-way valve connected upstream, the other pressure cylinder is switched so that the annular blade 51 moves in the return stroke direction 24.

[0090] In a press 12 with individually controllable pressure cylinders, it is for example possible to individually control both the movement of the individual tools 31, 51 and the pressure of the individual tools 31, 51 on the laminated web 80. When the working position 22 is reached, even in the case of such control, it is first possible to reduce the pressure of the laminated web 80 by the working surface 37 before the cutting tool 51 with the cutting blade 52 moves in the return stroke direction 24.

[0091] If the tool set 30 is arranged as a progressive tool, the embossing tool 31 is connected upstream of the annular blade 51 so that, for example, the laminate web 80 is transported in the transport direction 5 from the embossing station to the cutting station. In this case, the outer diameter of the embossing tool 31 can be larger than the diameter of the cutting blade 52.

[0092] FIG. 13 shows a tool set 30 with an assembled tool 71. This annular tool 71 has a cutting blade 52 and three working surfaces 37, 62, 63 formed coaxially with the cutting blade. A first working surface 37 is arranged in the cylinder formed by the cutting blade 52. This first working surface 37 is in the form of a flat surface and is parallel to the plane defined by the cutting blade 52. The first working surface is offset in the return stroke direction 24 with respect to this cutting plane. For example, the distance from the first working surface 37 to the plane of the cutting blade 52 is less than the sum of the thicknesses of the adhesive matrix layer 82 and the backing layer 83. The inner diameter of the first working surface 37 in the working surface plane is in this figure 95% of the diameter of the cutting blade 52 in a cutting plane parallel to the working surface plane.

[0093] The second working surface 62 and the third working surface 63 are configured, for example, as described in connection with the previous exemplary embodiment. The intersection of the working surfaces 62, 63 forms the cutting blade 52.

[0094] Use of this tool set 30 is carried out as described in connection with the first exemplary embodiment.

[0095] Combinations of the above exemplary embodiments are further contemplated.

Claims

1. 1. A tool set for producing an adhesive patch by processing a laminate web, comprising: A cutting tool having a cutting surface in a cutting plane; An embossing tool having a pressing surface on a pressing plane; It is equipped with The cutting plane and the pressing plane are parallel; The embossing tool is configured to press an edge area of ​​the adhesive patch to be produced; the cutting tool is configured to cut the adhesive patch to be produced by cutting within the edge region or outside the edge region; A tool set, wherein the cutting tool and the embossing tool are coaxially movable relative to each other.

2. The tool set of claim 1 , wherein the cutting tool and the embossing tool are coaxially movable and the cutting surface is circumferentially disposed relative to the pressing surface.

3. The tool set according to claim 1 or 2, wherein the cutting surface has a ring shape.

4. The tool set according to any one of claims 1 to 3, wherein the pressing surface has a ring shape.

5. A tool set according to any one of the preceding claims, wherein the cutting surface is offset to a recessed height at the cutting position relative to a base surface on which the laminate web is placed.

6. A tool set according to any one of the preceding claims, wherein the pressing surface is offset to a recessed height in a cutting position relative to a base surface on which the laminate web is placed.

7. The cut surface is biased to a height that protrudes relative to the pressing surface at least at the cutting position, and the height of the cut surface biased relative to the pressing surface corresponds to the height of a backing layer of the laminate web. A tool set according to any one of claims 1 to 6.

8. A tool set according to any one of the preceding claims, wherein an inner edge of the cutting surface and an outer edge of the pressing surface have substantially the same dimensions.

9. A tool set according to any one of claims 1 to 8, wherein the internal dimensions of the pressing surface are between 80% and 98% of the internal dimensions of the cutting surface.

10. A tool set according to any one of the preceding claims, wherein the inner dimension of the pressing surface is between 80% and 98% of the outer dimension of the cutting surface.

11. A method for manufacturing an adhesive patch using a tool set according to any one of claims 1 to 10, comprising the steps of: a) providing as an input material a laminated web having a backing layer, a support layer, and an adhesive matrix layer disposed between the backing layer and the support layer; b) pressing the edge areas of the adhesive patch to be produced onto the backing layer, thereby extruding adhesive matrix material under said edge areas; c) cutting the adhesive patch to be manufactured by cutting the backing layer outside the edge region. The method comprising:

12. The method of claim 11 , wherein in step b) the edge region is bent around the adhesive matrix layer.

13. 13. The method of claim 11 or 12, wherein the adhesive patch is cut by cutting through the backing layer and the adhesive matrix layer without cutting through the support layer.

14. The method according to any one of claims 11 to 13, further comprising the step of: d) removing said support layer.

15. The method of any one of claims 11 to 14, further comprising the step of: e) transferring and connecting the adhesive patch to a release liner.

16. The method of any one of claims 11 to 15, further comprising the step of: f) packaging.

17. An adhesive laminate produced by the method according to any one of claims 11 to 16, A backing layer, and Adhesive matrix layer It has the adhesive matrix layer is disposed on one side of the backing layer; The adhesive laminate, wherein the backing layer has a size larger than the adhesive matrix layer.

18. An adhesive laminate manufactured using the tool set according to any one of claims 1 to 10, A backing layer, and Adhesive matrix layer It has the adhesive matrix layer is disposed on one side of the backing layer; The adhesive laminate, wherein the backing layer has a size larger than the adhesive matrix layer.

19. An adhesive laminate produced by the method according to any one of claims 11 to 16 using the tool set according to any one of claims 1 to 10, A backing layer, and Adhesive matrix layer It has the adhesive matrix layer is disposed on one side of the backing layer; The adhesive laminate, wherein the backing layer has a size larger than the adhesive matrix layer.

20. The adhesive laminate according to any one of claims 17 to 19, wherein the backing layer overlaps the adhesive matrix layer.

21. the overlap region of the backing layer is an edge region of the backing layer; An adhesive laminate according to any one of claims 17 to 19, wherein the edge regions are in contact with less adhesive matrix material than the remainder of the backing layer, or are not in contact with the adhesive matrix material at all.

22. The adhesive laminate according to claim 20 or 21, wherein the overlapping region of the backing layer covers the periphery of the adhesive matrix layer.

23. The adhesive laminate according to any one of claims 20 to 22, wherein the overlapping region of the backing layer is bent around the adhesive matrix layer.

24. The area of ​​the adhesive laminate in the overlapping area of ​​the backing layer has an embossed portion; The adhesive laminate according to any one of claims 20 to 23, wherein the embossed portion forms a coating of the backing layer around the adhesive matrix layer.

25. The area of ​​the adhesive laminate in the overlapping area of ​​the backing layer has an embossed portion; The adhesive laminate according to any one of claims 20 to 24, wherein the embossed portion forms a bent portion of the backing layer around the adhesive matrix layer.

26. The area of ​​the adhesive laminate in the overlapping area of ​​the backing layer has an embossed portion; The adhesive laminate according to any one of claims 20 to 25, wherein the embossed portion forms an extruded area of ​​adhesive matrix material that contacts the overlapping area.

27. An adhesive patch intermediate product, At least one adhesive laminate according to any one of claims 17 to 26; With supporters It is equipped with the at least one adhesive laminate is disposed on the support layer; the adhesive matrix layer of the adhesive laminate is disposed between the support layer and the backing layer of the adhesive laminate; An adhesive patch intermediate product, wherein the overlapping region of the backing layer is in contact with the support layer such that the backing layer can be separated from the support layer.

28. 1. An adhesive patch product comprising: The adhesive laminate according to any one of claims 17 to 26, Liberated Liner and It is equipped with the adhesive matrix layer is disposed between the backing layer and the release liner; An adhesive patch product, wherein the overlap region of the backing layer is in contact with the release liner such that it can be separated from the release liner.

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