Porous carrier particles, functional component-carrying particles, and method for producing porous carrier particles

Abstract

Provided are porous carrier particles each of which contains a water-soluble polymer having a helical structure containing glucose as a unit, and has a BET specific surface area of 1 m2 / g or more. The water-soluble polymer is preferably a water-soluble polysaccharide. The water-soluble polysaccharide is preferably at least one component selected from the group consisting of dextrin, dextran, agarose and pullulan.

Description

[Technical field]

[0001] The present invention relates to porous carrier particles, functional component-supporting particles, and a method for producing porous carrier particles. This application claims priority based on Japanese Patent Application No. 2022-122676, filed on August 1, 2022, the contents of which are incorporated herein by reference. [Background technology]

[0002] Methods for administering functional ingredients such as active pharmaceutical ingredients into the body include topical administration, enteral administration, and parenteral administration. The administered functional ingredients must be transported from the site of introduction into the body to the target site where their function is expressed. In the case of oral administration, which is one type of enteral administration, the functional ingredient passes through the mouth and stomach and is absorbed in the small intestine. For this reason, the functional ingredient needs to be transported to the small intestine.

[0003] In order to transport functional ingredients to the target site in the body, it is useful to have a mechanism for supporting the functional ingredients on a support called a carrier. For example, a carrier is required to have a small particle size and a large capacity for the functional ingredient. Porous inorganic materials are being considered as such materials.

[0004] For example, Patent Document 1 discloses a crystalline mesoporous silica material having a zeolite-type microporous framework (defined as nanometer-sized structural units) that does not exhibit Bragg diffraction in X-ray diffraction, and the use of the material to deliver drugs. Patent Document 1 discloses that the release rate of the drug is less than 80% when using the zeolite material. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] Special Publication No. 2007-523817 Summary of the Invention [Problem to be solved by the invention]

[0006] A porous material formed from an inorganic compound is likely to have an increased specific surface area. On the other hand, inorganic compounds are water-insoluble and cannot be dissolved in the body, which poses the problem that not all of the functional components supported on the carrier are released, making it impossible to administer the desired dose to the body.

[0007] The present invention has been made in view of the above circumstances, and has an object to provide water-soluble porous carrier particles capable of supporting a functional component and having a high BET specific surface area. [Means for solving the problem]

[0008] The present invention encompasses the following [1] to [7]. [1] A water-soluble polymer with a helical structure consisting of glucose units, with a BET specific surface area of ​​1 m 2 / g or more. [2] The porous carrier particle according to [1], wherein the water-soluble polymer is a water-soluble polysaccharide. [3] The porous carrier particle according to [1] or [2], wherein the water-soluble polysaccharide is one or more selected from the group consisting of dextrin, dextran, agarose, and pullulan. [4] The porous carrier particle according to any one of [1] to [3], which is spherical. [5] A functional component-supported particle, comprising the porous carrier particle according to any one of [1] to [4] above supporting a functional component. [6] The functional component-supported particle described in [5], wherein the functional component is a medicinal ingredient. [7] BET specific surface area is 1m 2 / g or more, the method comprising the steps of spray-drying a solution containing a water-soluble polymer having a helical structure with glucose units to obtain precursor particles, mixing the precursor particles with an organic solvent to obtain a mixture, and then removing the liquid from the mixture. Effect of the Invention

[0009] According to the present invention, it is possible to provide water-soluble porous carrier particles that are capable of supporting a functional component and have a high BET specific surface area. [Brief description of the drawings]

[0010] [Figure 1] 1 is an electron microscope photograph of the porous carrier particles produced in Example 1. [Diagram 2] 1 is an electron microscope photograph of the porous carrier particles produced in Example 2. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0011] <Porous carrier particles> The porous carrier particles of the present invention contain a water-soluble polymer and are water-soluble. Hereinafter, the porous carrier particles of the present invention may be referred to as "carrier particles". Water-soluble carrier particles dissolve completely in vivo. Therefore, both the supported functional component and the carrier particles dissolve completely in vivo, and the functional component can be completely released. In addition, since the carrier particles are porous, the contact area with the surrounding medium liquid is increased, and the carrier particles can also exhibit rapid dissolution.

[0012] As water-soluble porous particles, for example, known water-soluble porous particles described in JP-A-4-335870 have a BET specific surface area of ​​0.2 m 2 / g or less, making the specific surface area extremely small.

[0013] In contrast, the carrier particles of the present invention have a higher specific surface area than conventional water-soluble porous particles, and therefore can support a larger amount of functional components than conventional water-soluble porous particles.

[0014] "Water-soluble" means having a solubility of 1 g or more in 100 g of distilled water at 25° C. and 1 atmospheric pressure.

[0015] "Porous" means that the material has many pores and a BET specific surface area of ​​1 m2 / g or more.

[0016] The carrier particles preferably consist essentially of a water-soluble polymer. Here, "consisting essentially of a water-soluble polymer" means that the carrier particles consist only of a water-soluble polymer, and that the carrier particles contain other components to the extent that their function as a carrier for the functional component is not impaired.

[0017] "Does not reduce the function as a carrier for functional ingredients, etc." means that the amount of functional ingredients carried is not reduced, and when used as a pharmaceutical, it can be administered to the body, etc. Specifically, it means that the content of other ingredients is 1% by mass or less of the entire carrier particle, and preferably 0.1% by mass or less. Each component will be described below.

[0018] ≪Water-soluble polymer≫ The water-soluble polymer in this embodiment has a helical structure with glucose units. Whether or not the carrier particles contain a water-soluble polymer having a helical structure with glucose units can be confirmed by the following method.

[0019] According to the method for identifying dextrin described in the 18th Japanese Pharmacopoeia, page 1150, add 100 mL of water to 0.1 g of carrier particles, and then add one drop of iodine test solution. If the liquid turns light reddish brown or light reddish purple after the addition of the iodine test solution, it is determined that the carrier particles contain a water-soluble polymer with a helical structure that consists of glucose units.

[0020] The water-soluble polymer used in this embodiment is preferably a natural polymer from the viewpoint of safe administration when the carrier particles are used for pharmaceutical purposes. Specifically, water-soluble polysaccharides can be used as the natural polymer.

[0021] The water-soluble polysaccharide used in this embodiment is a water-soluble polymer having a helical structure formed by polymerizing glucose in a chain shape. The water-soluble polysaccharide preferably has a multi-branched three-dimensional network structure.

[0022] The water-soluble polysaccharide having a three-dimensional network structure is preferably one or more selected from the group consisting of dextrin, dextran, agarose, and pullulan, and among these, dextrin is more preferable.

[0023] From the viewpoint of safe administration, it is preferable that the water-soluble polymer does not contain any metal element, and it is also preferable that the entire carrier particle does not contain any metal element.

[0024] The method for producing carrier particles will be described in detail below, but after a solution containing a water-soluble polymer is spray-dried to obtain precursor particles, the precursor particles obtained are mixed with an organic solvent to obtain a mixture, and the liquid is removed from the mixture to obtain carrier particles.

[0025] When a water-soluble polymer has a three-dimensional mesh structure, some of the glucose chains (e.g., maltose, maltotriose, etc.) contained in the three-dimensional mesh structure (precursor particle) are extracted and removed with an organic solvent, and the areas where the extract was present become micropores, forming carrier particles.

[0026] ≪Optional ingredients≫ The carrier particles preferably do not contain any organic acid, which will be described later, but may contain a small amount of the organic acid. The phrase "the carrier particles do not contain organic acid" means that when the amount of organic acid contained in the carrier particles is measured, the measured amount of organic acid is below the detection limit.

[0027] In the manufacturing process of the carrier particles, an organic acid may or may not be used, but if used, it is finally removed. Depending on the removal method, a small amount of organic acid may remain in the carrier particles. In this case, the amount of organic acid in the carrier particles, measured by the following method, is preferably 1% or less.

[0028] [Method for measuring organic acids in carrier particles] The organic acid can be detected by dissolving the carrier particles in an aqueous phosphoric acid solution and then analyzing the result by high performance liquid chromatography (HPLC).

[0029] ≪BET specific surface area≫ The carrier particles have a BET specific surface area of ​​1 m 2 / g or more, and 2 / g or more is preferable, and 50m 2 / g or more is more preferable, and 100m 2 / g or more is particularly preferable, and 150m 2 The upper limit of the BET specific surface area is, for example, 1000 m 2 / g or less, 900m 2 / g or less, 800m 2 / g or less. The above upper and lower limits of the BET specific surface area can be arbitrarily combined. 2 / g or more 1000m 2 / g or less, 40m 2 / g or more 1000m 2 / g or less, 50m 2 / g or more 1000m 2 / g or less, 100m 2 / g or more 900m 2 / g or less, 150m 2 / g or more 800m 2 / g or less.

[0030] [Method for measuring BET specific surface area] The BET specific surface area of ​​the carrier particles is measured by the nitrogen adsorption BET (Brunauer, Emmett, Teller) method using a specific surface area measuring device, such as a specific surface area measuring device manufactured by Mountech Co., Ltd. (device name: Macsorb).

[0031] ≪Shape≫ The shape of the carrier particles is not particularly limited, but is preferably spherical. The particle shape can be confirmed by static image analysis. Static image analysis can be performed using an automatic static image analyzer, such as Morphologi 4 manufactured by Malvern Panalytical.

[0032] <Particle size> The average particle size of the carrier particles can be, for example, in the range of 5 μm or more and 1000 μm or less, 10 μm or more and 800 μm or less, 20 μm or more and 600 μm or less, 30 μm or more and 500 μm or less, 40 μm or more and 400 μm or less, or 50 μm or more and 300 μm or less.

[0033] [Method of measuring average particle size] The average particle size of the carrier particles can be measured by laser diffraction or laser scattering.

[0034] The method for producing carrier particles of the present invention will be described below.

[0035] <Method of manufacturing carrier particles> The method for producing carrier particles will be described by taking as an example the case of producing spherical carrier particles. The carrier particles can be produced by the following Production Method 1 or Production Method 2.

[0036] ≪Manufacturing method 1≫ The method 1 for producing carrier particles includes a step of obtaining precursor particles using a water-soluble polymer (production raw material), and a step of obtaining carrier particles.

[0037] [Step of obtaining precursor particles] First, a water-soluble polymer as a production raw material is dissolved in water to obtain an aqueous solution. The aqueous solution is then spray-dried to obtain precursor particles. A known spray drying device can be used for spray-drying. The concentration of solids (solutes) contained in the aqueous solution is preferably in the range of 30% or more and 80% or less, and more preferably 40% or more and 60% or less.

[0038] If the concentration of the solid content in the aqueous solution is equal to or higher than the lower limit, the precursor particles have a solid structure and more pores are formed when the precursor particles are mixed with an organic solvent in a later step and the liquid is removed.If the concentration of the solid content in the aqueous solution is equal to or lower than the upper limit, spray drying is easy and the precursor particles and the carrier particles obtained in the later step become closer to spherical.

[0039] An example of the spray drying conditions is an inlet temperature of 120° C. to 160° C., an outlet temperature of 80° C. to 120° C., and a supply rate of the aqueous solution of 5 kg / hour to 25 kg / hour. The water-soluble polymer is the same as that described above in the <Porous carrier particles>.

[0040] [Process for obtaining carrier particles] The precursor particles are mixed with an organic solvent and the liquid is removed from the mixture. As the organic solvent, known organic solvents can be used. In this embodiment, hydrophilic organic solvents are preferred, and examples of hydrophilic organic solvents include ethanol and methanol.

[0041] The precursor particles are suspended in a heated organic solvent and held for a predetermined time or longer, thereby mixing the precursor particles with the organic solvent. The heating temperature and time can be appropriately adjusted according to the organic solvent used, but for example, the temperature is 0°C to 70°C and the temperature is held for 10 minutes to 120 minutes.

[0042] Next, by removing the liquid from the mixture, a portion of the glucose chains (e.g., sugars with glucose as the base unit, such as maltose and maltotriose) that make up the water-soluble polymer (manufacturing raw material) is removed from the precursor particles, and the removed area becomes pores, resulting in carrier particles.

[0043] The liquid to be removed here is an organic solvent that contains a portion of the glucose chain that constitutes the water-soluble polymer (manufacturing raw material).

[0044] In the production method 1, an example of a water-soluble polymer used as a production raw material is dextrin. The saccharification rate of starch in the dextrin used as a raw material for production is not particularly limited, and may be dextrin with a DE value of 10 or less, maltodextrin with a DE value of more than 10 and less than 20, or dextrin with a DE value of more than 20.

[0045] The liquid can be removed from the mixture by a known method, such as filtration or decantation. The particles obtained by removing the liquid are mixed with an organic solvent again, and the liquid is removed from the mixture. This process is repeated to increase the specific surface area of ​​the resulting carrier particles.

[0046] In particular, when dextrin with a high content of maltose or maltotriose is used as the raw material, the traces of maltose or maltotriose left behind after removal become pores, making it easier to obtain carrier particles with a high BET specific surface area.

[0047] ≪Manufacturing method 2≫ The method 2 for producing carrier particles includes a step of obtaining precursor particles, which are particles of a water-soluble polymer (manufacturing raw material), and a step of obtaining carrier particles. The difference from the above-mentioned manufacturing method 1 is that a template (mold) is added to the aqueous solution in the step of obtaining the precursor particles. As the template, an organic acid, sugar or sugar alcohol can be used.

[0048] (organic acid) The organic acid is preferably citric acid, malic acid, tartaric acid, succinic acid, or adipic acid, and more preferably citric acid, malic acid, or tartaric acid.

[0049] (Sugar or sugar alcohol) The sugar may be, for example, a monosaccharide or a disaccharide. The monosaccharides that can be used are glucose, fructose, and galactose. Examples of the disaccharide that can be used include sucrose, lactose, maltose, trehalose, and cellobiose. Of these, maltose and trehalose are preferred, and trehalose is particularly preferred.

[0050] Sugar alcohols include mannitol, erythritol, or xylitol. Production method 2 is preferably used when dextrin with a low content of maltose or maltotriose is used as a production raw material. In this production method 2, the removal traces of the added template become pores instead of the maltose or maltotriose in the dextrin used as a production raw material, making it easier to obtain carrier particles with a high BET specific surface area.

[0051] <Functional component supporting particles> The present invention relates to functional component-supported particles in which a functional component is supported on the above-mentioned carrier particles. Examples of functional ingredients include medicinal ingredients, pharmaceutical additives, functional food ingredients, colorants, and flavorings.

[0052] The carrier particles of the present embodiment are rapidly soluble and can release all of the carried ingredients, and therefore can be suitably used as carriers for medicinal active ingredients.

[0053] Examples of the pharmaceutical active ingredient to be supported include one or more ingredients selected from antipyretic analgesic and anti-inflammatory drugs, psychotropic drugs, antianxiety drugs, antidepressants, sedatives for sleep, antispasmodics, drugs acting on the central nervous system, drugs improving brain metabolism, drugs improving brain circulation, antiepileptic drugs, sympathomimetics, gastrointestinal drugs, antacids, antiulcer drugs, antitussives and expectorants, antiemetics, respiratory stimulants, bronchodilators, allergy drugs, dental and oral drugs, antihistamines, cardiac stimulants, drugs for arrhythmia, diuretics, antihypertensive drugs, vasoconstrictors, coronary vasodilators, peripheral vasodilators, drugs for hyperlipidemia, choleretic drugs, antibiotics, chemotherapy drugs, drugs for diabetes, drugs for osteoporosis, antirheumatic drugs, antispasmodics, hormone drugs, alkaloid narcotics, sulfa drugs, drugs for treating gout, blood coagulation inhibitors, anti-malignant tumor drugs, and tonics and health supplements.

[0054] Examples of functional food ingredients include vitamins such as vitamin A, vitamin D, and vitamin E, and higher unsaturated fatty acids such as DHA (docosahexaenoic acid), EPA (eicosapentaenoic acid), and cod liver oil.

[0055] The method for making the carrier particles carry the functional component is preferably to impregnate the carrier particles with the desired functional component, for example, the method described in US10004682B2 can be used for such a method.

[0056] Examples of the method for making the carrier particles carry the functional component include the following methods. First, the functional component is dissolved in an organic solvent to obtain a functional component solution. The organic solvent is, for example, ethanol. At this time, a small amount of water (about 1% of the total amount of the functional component solution) may be added to the organic solvent in order to improve the solubility of the functional component. Thereafter, the carrier particles and the functional ingredient solution are mixed. The method of mixing the carrier particles with the functional component solution includes a method in which the obtained functional component solution is dropped or sprayed onto the carrier particles. A predetermined amount of the functional ingredient solution and the carrier particles are mixed, and then the mixture is dried under reduced pressure at a temperature of 20° C. or higher and 60° C. or lower, to obtain carrier particles carrying the functional ingredient.

[0057] <Powdered base material for oily substances> The carrier particles of the present embodiment have high affinity for oily substances and can be suitably used as a powder base material for oily substances.

[0058] <Catalyst or catalyst carrier> The carrier particles of the present embodiment may be used as a catalyst or as a catalyst support. Examples of the catalyst to be supported include catalysts containing platinum, palladium, iridium as a main component, and titanium oxide. EXAMPLES

[0059] Next, the present invention will be described in more detail with reference to examples. In the following, Example 3 is considered as a reference example.

[0060] <Example 1> [Step of obtaining precursor particles] 2.0 kg of dextrin (GLUCIDEX IT47) was dissolved in 3.0 kg of water heated to 70° C. to obtain an aqueous solution 1. The DE value of the dextrin used was 47. Aqueous solution 1 was sprayed with a spray dryer under the following conditions to obtain precursor particles 1. (Spraying conditions) Inlet temperature: 140℃ Outlet temperature: 96~100℃ Disk rotation speed: 5000 rpm Supply rate of aqueous solution: 7 kg / hour

[0061] [Process for obtaining carrier particles] 60 ml of absolute ethanol was added to 3 g of precursor particles, and the mixture was shaken and mixed in a water bath at 50°C for 10 minutes. After shaking, the mixture was left to stand for 2 minutes, and the supernatant was removed by decantation. 60 ml of absolute ethanol was added again, and the mixture was shaken and decanted in the same manner as above, and this was repeated 10 times in total from the beginning. After the final decantation, the mixture was dried overnight at 40°C and -0.1 MPa, and passed through an 83M sieve to obtain carrier particles 1.

[0062] Carrier Particle 1 satisfied the conditions of water solubility and porosity defined in this specification.

[0063] An electron microscope photograph (magnification: 2000 times) of carrier particles 1 is shown in Fig. 1. As shown in Fig. 1, carrier particles 1 were spherical.

[0064] The specific surface area of ​​carrier particle 1 measured by the above [BET specific surface area measurement method] is 174 m 2 / g.

[0065] The pore diameter of the carrier particle 1 is 11.9 nm and the pore volume is 0.52 cm 3 / g.

[0066] <Example 2> [Step of obtaining precursor particles] 9 kg of water (water temperature 70°C), 12.6 kg of trehalose (Trehalose P, manufactured by Hayashibara Co., Ltd.), 6.3 kg of dextrin (Sandec #300, manufactured by Sanwa Starch Co., Ltd.) and 2.1 kg of anhydrous citric acid were mixed to obtain an aqueous solution 2 with a solids concentration of 70%. The DE of the dextrin used was 27. Aqueous solution 2 obtained under the following conditions was sprayed with a spray dryer to obtain precursor particles 2. (Spraying conditions) Inlet temperature: 140℃ Outlet temperature: 101℃ Disk rotation speed: 8000 rpm Aqueous solution supply rate: 23 kg / hour

[0067] [Process for obtaining carrier particles] 300 ml of anhydrous ethanol was added to 15 g of the obtained precursor particles, and the mixture was shaken and mixed in a water bath at 50°C for 15 minutes. After shaking, the mixture was left to stand for 2 minutes, and the supernatant was removed by decantation. 300 ml of anhydrous ethanol was added again, and the mixture was shaken and decanted in the same manner as above, and this was repeated 10 times in total from the beginning. After the final decantation, the mixture was dried at 40°C and -0.1 MPa for 2 hours, and passed through an 83M sieve to obtain carrier particles 2.

[0068] Carrier particles 2 met the conditions of water solubility and porosity defined in this specification.

[0069] An electron microscope photograph (magnification: 2000 times) of carrier particles 2 is shown in Fig. 2. As shown in Fig. 2, carrier particles 2 were spherical.

[0070] The specific surface area of ​​carrier particle 2 measured by the above [Method of measuring BET specific surface area] is 144 m 2 / g.

[0071] The pore diameter of the carrier particle 2 is 13.8 and the pore volume is 0.50 cm 3 / g.

[0072] <Example 3> [Step of obtaining precursor particles] 400 g of water (water temperature 70°C), 390 g of trehalose (Trehalose P, manufactured by Hayashibara Co., Ltd.), 180 g of dextrin (Pinedic #3, manufactured by Matsutani Chemical Industry Co., Ltd.), and 30 g of anhydrous citric acid were mixed to obtain an aqueous solution 3 with a solid content concentration of 60%. The DE of the dextrin used was 25. The aqueous solution 3 obtained under the following conditions was sprayed with a spray dryer to obtain precursor particles 3. (Spraying conditions) Inlet temperature: 140℃ Outlet temperature: 98℃ Disk rotation speed: 10000 rpm Aqueous solution supply rate: 100ml / min

[0073] [Process for obtaining carrier particles] 20 ml of absolute ethanol was added to 5 g of the obtained precursor particles, and the mixture was shaken and mixed in a water bath at 60°C for 30 minutes to 1 hour. After shaking, the mixture was left to stand, and the supernatant was removed by decantation. 20 ml of absolute ethanol was added again, and the mixture was shaken and decanted in the same manner as above, and this was repeated a total of 11 times from the beginning. After the final decantation, 20 ml of absolute ethanol was added, mixed lightly, and left to stand, then decanted and the supernatant was removed. The mixture was dried at 50°C and -0.08 MPa to obtain carrier particles 3.

[0074] Carrier particles 3 met the conditions of water solubility and porosity as defined herein.

[0075] The specific surface area of ​​the carrier particles 3 measured by the above [Method of Measuring BET Specific Surface Area] is 7.64 m 2 / g.

[0076] <Example 4> [Step of obtaining precursor particles] 1000 g of water (water temperature 70° C.), 1500 g of trehalose (Hayashibara Co., Ltd., Trehalose P), 600 g of dextrin (GLUCIDEX IT29, ROQUETTE), and 233 g of anhydrous citric acid were mixed to obtain an aqueous solution 4 with a solid content concentration of 70%. The DE of the dextrin used was 29. The aqueous solution 4 obtained under the following conditions was sprayed with a spray dryer to obtain precursor particles 4. (Spraying conditions) Inlet temperature: 140℃ Outlet temperature: 99-100℃ Disk rotation speed: 13000 rpm Aqueous solution supply rate: 100ml / min

[0077] [Process for obtaining carrier particles] 120 ml of absolute ethanol was added to 6 g of the obtained precursor particles, and the mixture was shaken and mixed in a water bath at 40°C for 10 minutes. After shaking, the mixture was left to stand for 5 minutes, and the supernatant was removed by decantation. 120 ml of absolute ethanol was added again, and the mixture was shaken and decanted in the same manner as above, and this was repeated a total of 10 times from the beginning. After the final decantation, 120 ml of absolute ethanol was added, mixed lightly, and left to stand for 5 minutes, then decanted and the supernatant was removed. The mixture was dried at 50°C and -0.08 MPa to obtain carrier particles 4.

[0078] Carrier particles 4 met the conditions of water solubility and porosity as defined herein.

[0079] The specific surface area of ​​the carrier particles 4 measured by the above [Method of measuring BET specific surface area] is 67.29 m 2 / g.

[0080] <Example 5> Carrier particles 5 were obtained in the same manner as in Example 4, except that the dextrin was changed to dextrin (GLUCIDEX IT33, manufactured by ROQUETTE).

[0081] Carrier particles 5 met the conditions of water solubility and porosity as defined herein.

[0082] The specific surface area of ​​the carrier particles 5 measured by the above [Method of Measuring BET Specific Surface Area] is 82.17 m 2 / g.

[0083] The carrier particles of Examples 1 to 5 are porous and have a high specific surface area, so that the amount of functional component supported can be increased. In addition, the porous carrier particles of Examples 1 to 5 are water-soluble, so that they are completely dissolved in vivo. Therefore, both the supported functional component and the carrier particles are completely dissolved in vivo, and the functional component can be completely released.

Claims

1. The porous carrier particles contain a water-soluble polymer having a helical structure with glucose units and have a BET specific surface area of ​​40 m 2 / g or more.

2. The porous carrier particles according to claim 1 , wherein the water-soluble polymer is a water-soluble polysaccharide.

3. The porous carrier particles according to claim 2 , wherein the water-soluble polysaccharide is one or more selected from the group consisting of dextrin, dextran, agarose, and pullulan.

4. 3. The porous carrier particles of claim 1 or 2, which are spherical.

5. 3. A functional component-supported particle, comprising the porous carrier particle according to claim 1 or 2 supported with a functional component.

6. The functional component-supporting particle according to claim 5 , wherein the functional component is a medicinal active ingredient.

7. A method for producing porous carrier particles having a BET specific surface area of ​​40 m 2 / g or more, comprising the steps of: A step of spray-drying a solution containing a water-soluble polymer having a helical structure composed of glucose units to obtain precursor particles; mixing the precursor particles with an organic solvent to obtain a mixture, and then removing liquid from the mixture.

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