Aerosol device for inhaling a substance, method for inhaling a substance, and uses thereof

Abstract

To disclose devices, cartridges, and method for emulating smoking.SOLUTION: The device generates an aerosol for inhalation by a subject by heating a viscous material that can have a tactile response in the mouth or respiratory tract, while reducing Hoffman analytes and mutagenic compounds delivered to the user as compared to a common tobacco cigarette.SELECTED DRAWING: Figure 1

Description

[Technical field]

[0001] (cross reference) This application claims priority to U.S. patent application Ser. No. 12 / 336,439, filed Dec. 16, 2008, and claims the benefit of U.S. Provisional Application No. 61 / 014,690, filed Dec. 18, 2007, both of which are incorporated herein by reference.

[0002] There has been an increasing attention worldwide to the use of tobacco products and the harmful side effects of tobacco smoking. The more restrictions there are on smoking in places of work or in public places, the more interest there is in developing alternative products. One way to reduce the harmful side effects of smoking is to not burn tobacco products, as many of the harmful analytes obtained from smoking, such as Hoffmann analytes, are ingested by the burning of materials. Summary of the Invention [Problem to be solved by the invention]

[0003] The challenge in developing and marketing a device capable of delivering aerosolized tobacco products is to meet the desires of the user in terms of visual and physical appeal of use. A device that can be used multiple times to aerosolize a variety of different substances while providing the user with a similar visual sensation of smoking, such as visible vapor, is desirable. Also desirable are devices and products that can aerosolize tobacco products and deliver reduced Hoffman analytes and mutagenic compounds to the user compared to smoking. [Means for solving the problem]

[0004] In one aspect of the present invention, a cartridge for use in a device for aerosolizing a material is disclosed, which includes a case (shell) containing a high viscosity volatile material and a lid sealing over the case, thereby forming a sealed cartridge containing the high viscosity volatile material. The lid can be permeable, and the permeable lid can be an outlet for the aerosol generated by heating the high viscosity volatile material. The lid can also be a heat sealable film, and the heat sealable film includes a base layer and a heat sealable layer. The cartridge case or the cartridge lid can include aluminum. When the cartridge case of the present invention includes a flange, the lid can seal over the flange.

[0005] The cartridge can be heated to a temperature necessary to aerosolize the material contained within the case, preferably below 400° F. (204° C.). The high viscosity volatile material within the cartridge can comprise at least one of an aerosol-forming vehicle, propylene glycol, or glycerin. The high viscosity volatile material can include tobacco.

[0006] The cartridge can be inserted into the device, and the device can be capable of aerosolizing a high viscosity volatile material. The device can include an oven chamber capable of heating the cartridge.

[0007] To label the cartridges of the present invention, information can be printed on at least one of the case and the lid.

[0008] In another embodiment, a method for loading a cartridge containing a high viscosity volatile material comprises filling the high viscosity volatile material into a cartridge case and sealing a lid on the cartridge case. The method can be automated, for example, performed on a linear or rotary indexer, or can be filled using an auger filler, a peristaltic pump, or a piston pump. During the filling step, a volume of the high viscosity volatile material can be filled, and the volume can be from about 0.1 to about 0.8 cubic centimeters. The volume is preferably about 0.25 cubic centimeters. The sealing step of the method for loading a cartridge can comprise heating at least one of the lid and the case of the cartridge, and trimming any excess material from the lid.

[0009] A device for generating an inhalable aerosol is disclosed herein that includes a body, a heater within the body capable of heating a volatile material of high viscosity to generate an inhalable aerosol, and a temperature control means including one or more bimetallic disks that convert a temperature change into a mechanical displacement. The inhalable aerosol can include particles less than about 2 microns in diameter. The heater of the device can be supplied with a gaseous fuel, such as butane, and ignited by a piezoelectric igniter.

[0010] The temperature control disk can move a push rod which in turn pushes a configurable flow restriction valve to restrict or stop the flow of gaseous fuel within the device body and can also provide support for a catalyst mesh element.

[0011] In another embodiment, the present invention provides a device for simulating smoking, the device generating an aerosol for inhalation by a human by heating a high viscosity material including plant matter to about 150° C., the aerosol producing a tactile response in the oral cavity or respiratory tract. The high viscosity material can include an aerosol-forming medium, the aerosol-forming medium including at least one of propylene glycol and glycerin, capable of producing a visible aerosol when heated. The high viscosity material can also include tobacco and flavorings.

[0012] The device can also deliver the active ingredient to the user as part of an aerosol, where the active ingredient can be absorbed in the respiratory tract, and the aerosol can include particles less than about 2 microns in diameter.

[0013] Disclosed herein is a device of the present invention, including a body and a heater, which generates a smokeless aerosol for human inhalation by heating a high viscosity tobacco material to a target temperature. The high viscosity material can include an aerosol-forming medium, which can include at least one of propylene glycol and glycerin to produce a visible aerosol when heated. The device can also deliver an active ingredient that is part of the aerosol to a user. The active ingredient can be absorbed in the respiratory tract. The aerosol can also include particles less than about 2 microns in diameter.

[0014] The target temperature for heating the high viscosity material in the apparatus can be from about 100° C. to about 200° C. The target temperature is preferably about 150° C.

[0015] Additionally, the device can be operated by a user with one hand.

[0016] In another aspect of the present invention, an aerosol generating device is disclosed, the device generating an aerosol that is substantially free of at least one Hoffman analyte upon heating a smokable material to a target temperature, the Hoffman analyte may be selected from the group consisting of ammonia, aminonaphthalene, benzopyrene, formaldehyde, acetaldehyde, acetone, methyl ethyl ketone, butyraldehyde, hydrogen cyanide, nitric oxide, tobacco specific nitrosamines (TSNAs), pyridine, quinoline, hydroquinone, phenol, cresol, tar, nicotine, carbon monoxide, 1,3-butadiene, isoprene, acrylonitrile, benzene, toluene, and styrene.

[0017] The target temperature for heating the high viscosity material in the device can be from about 100° C. to about 200° C. The target temperature is preferably about 150° C., which generates an aerosol containing particles less than about 2 microns in diameter.

[0018] The present invention also provides an aerosol generating device, the device generating an aerosol having at least 70% less Hoffman analytes than conventional shredded tobacco cigarettes upon heating smokable material to a target temperature, the Hoffman analytes may be selected from the group consisting of ammonia, aminonaphthalene, benzopyrene, formaldehyde, acetaldehyde, acetone, methyl ethyl ketone, butyraldehyde, hydrogen cyanide, nitric oxide, tobacco specific nitrosamines (TSNAs), pyridine, quinoline, hydroquinone, phenol, cresol, tar, nicotine, carbon monoxide, 1,3-butadiene, isoprene, acrylonitrile, benzene, toluene, and styrene. The conventional shredded tobacco cigarette may include a filter.

[0019] The target temperature for heating the high viscosity material in the device can be from about 100° C. to about 200° C. The target temperature is preferably about 150° C., which generates an aerosol containing particles less than about 2 microns in diameter.

[0020] In one aspect, the present invention discloses a method of delivering an aerosol substantially free of Hoffman analytes to a person, comprising: disposing an aerosol generating device including a heater and smokable material; heating the smokable material with the heater of the device to a target temperature that generates an aerosol; and delivering the aerosol to the person for inhalation.

[0021] In another embodiment, a method of generating a tactile response in the oral cavity or respiratory tract is disclosed. The method includes: disposing a smoking mimicking device, the device generating a smokeless aerosol having a tactile response in the oral cavity or respiratory tract by heating a high-viscosity material containing a plant material contained therein; heating the high-viscosity material to a target temperature; generating an aerosol having a tactile response in the oral cavity or respiratory tract from the heated high-viscosity material; and inhaling the aerosol. The high-viscosity material can include an aerosol-forming medium, and the aerosol-forming medium can include at least one of propylene glycol and glycerin that generate a visible aerosol when heated. Also, the high-viscosity material can include at least one of tobacco and flavoring. The device can deliver an active ingredient that is part of the aerosol to a user. The active ingredient can be absorbed into the respiratory tract. The aerosol can include particles less than about 2 microns in diameter.

[0022] In another aspect, the present invention discloses an aerosol generating device provided by the present invention, the device generating an aerosol from a smokable material, the aerosol containing at least 70% less Hoffman analytes than substances generated by combustion of the smokable material.

[0023] Also disclosed are aerosol generating devices that generate an aerosol from a smokable material that passes the Ames test, and aerosol generating devices that generate an aerosol from a smokable material that scores significantly better in the Ames test than material generated by combustion of the smokable material.

[0024] The present invention provides an aerosol generating device, which provides aerosol for inhalation to a user for at least four uninterrupted hours without refueling or caring for the device.

[0025] (Incorporated by reference) All publications, patents, and patent applications mentioned in this specification are herein incorporated by reference to the same extent as if each individual publication, patent, and patent application was specifically and individually indicated to be incorporated by reference.

[0026] A better understanding of the features and advantages of the present invention will be obtained by reference to the following detailed description that sets forth illustrative embodiments, in which the principles of the invention are utilized, and the accompanying drawings of which: [Brief description of the drawings]

[0027] [Figure 1] FIG. 1 shows a device of the present invention including a mouthpiece and a body having a heater, a furnace chamber, a fuel tank, and an igniter with a regulation means for maintaining an operating temperature. [Diagram 2] FIG. 1 shows an apparatus of the present invention including a fuel tank that is refillable and has an access port for that purpose. [Diagram 3] FIG. 1 illustrates an apparatus of the present invention that includes a heater assembly that can be powered by any combustible fuel and a series of bimetallic objects that control the flow of combustible fuel to the heater assembly. [Figure 4] FIG. 1 shows an apparatus in which fuel is supplied to a tank via a fill valve and compressed liquid fuel can be withdrawn for use by a wick. [Diagram 5] FIG. 1 illustrates a device of the present invention that includes a single elastomeric stopper that limits gas movement, where the flow of gas fuel is restricted by a compressed foam flow restrictor and can only be released through an orifice in a valve. [Figure 6]FIG. 13 illustrates a device in which the exhaust holes in the plastic body are positioned above the heater exhaust holes so that the exhausting gases must pass along the heater body, exchanging even more of their heat, thereby improving the efficiency of the device. [Figure 7] FIG. 1 shows a device of the present invention with a hinged mouthpiece. [Figure 8A] FIG. 1 illustrates a device that allows a user to slide a string of material toward the mouthpiece end of the device to ignite it, and then slide the string back toward the fill port to extinguish it. [Figure 8B] FIG. 8B shows the device of FIG. 8A from a different perspective. [Figure 9] FIG. 1 shows a cartridge capable of containing a volatile product in a wet state, for use with a device capable of evaporating the product, comprising a case, a lid, and a flange for adhering the lid to the case. [Figure 10] FIG. 1 shows a basic heat sealable film comprising a PET base layer and an APET heat seal layer. [Figure 11] FIG. 1 shows a composite film comprising a PET base layer and an APET heat seal layer, but with an additional metal layer and a metal adhesive layer. [Figure 12] FIG. 1 illustrates a cartridge of the present invention that contains a moist volatile product and includes a hole or vent that allows the contents within the cartridge to access the environment. [Figure 13A] FIG. 1 shows a cartridge with two parts that can fit together and can have holes or vents for releasing vapor from the contents of the cartridge. [Figure 13B] FIG. 1 shows a cartridge with two parts that can fit together and can have holes or vents for releasing vapor from the contents of the cartridge. [Figure 14] FIG. 1 illustrates an exemplary method of using a device of the present invention that can mimic smoking by providing many of the desired smoking effects desired by the user while reducing the inhalation of Hoffman analytes. [Figure 15] FIG. 1 illustrates an exemplary method of using the device of the present invention, which allows a user to receive inhaled tobacco material from the device with at least 70% reduction in the user's intake of Hoffman analytes, and allows the user to exhale a visual vapor from a vapor-forming medium, providing a visual aid similar to the smoke exhaled in the act of smoking. [Figure 16] FIG. 1 shows the results of a bacterial mutagenicity test (Ames test) demonstrating that particles generated by smoking a device of the present invention are not mutagenic. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0028] The invention described herein has a wide range of applications for inhalation of active substances, as can be understood by those skilled in the art by reviewing this disclosure. For example, the devices, cartridges, systems, kits and methods can be used to inhale, for example, tobacco products via the mouth or nose. The devices, systems, kits and methods can also be used to reduce the Hoffman analytes provided to the user by inhaling tobacco products compared to smoking or burning tobacco. Furthermore, the devices, systems, kits and methods can be used to inhale any substance, such as, for example, botanicals, medicines, nutrients, or any other substance that provides a benefit or impression to the end user.

[0029] I. Aerosol Generator An exemplary device of the present invention is shown in FIG. 1. The device 100 is capable of generating a temperature high enough to aerosolize a product contained within the device 100. The device of the present invention can include a mouthpiece 110 and a body 120 having a heater 122, a furnace chamber 124, a fuel tank 126, and an igniter with an adjustment means for maintaining the operating temperature. An example of an adjustment means for the operating temperature of the device is a bimetallic actuator. Alternatively, a paraffin-filled expandable part can be used to adjust the flow of butane. Alternatively, a system can be used by measuring the current temperature, for example by a thermocouple sensor, comparing it to a predetermined temperature, for example by a micro-adjustment means, and controlling an electromechanical valve, for example a servo or solenoid valve. The user selected temperature can be used as an input to this system, as described above.

[0030] The device can be fabricated without any active control elements. This results in reduced complexity and lower overall manufacturing costs for the device. For example, the fuel flow to the heater 122 can be set at a low level. In use, the temperature within the chamber furnace 124 will rise to an equilibrium point where the additional heat introduced equals the heat lost to the environment. Heat is lost by conduction in the body of the device 100 and by steam delivered to the user. This equilibrium point determines the operating temperature of the device 100. By varying the fuel flow rate, the size and material of the burner, and other factors, the system can be calibrated to provide a sufficiently stable desired operating temperature.

[0031] A piezoelectric igniter may be used. Other igniters may be used, such as a flint igniter or a battery-powered resistive coil.

[0032] As shown in FIG. 2, the device 200 of the present invention may also include a refillable fuel tank 226 and an access port 230 for that purpose. The tank 226 may be disposable once its fuel is consumed. A release mechanism such as a pin or cam may be used to allow the user to quickly remove an empty tank 226 and replace it with a full tank. A replaceable tank may include additional components of the device such as an igniter or heater. Although liquid fuel is the preferred fuel source, the liquid fuel may be supplemented or replaced by a battery-powered electric heater or other small heat source. The tank 126 may be filled with a specific fuel source or a standard commercially available fuel source by a fill valve mechanism 128 as shown in FIG. 1.

[0033] The fuel tank can hold enough fuel for repeated use of the device. The device can be used up to 10, 20, 30, 40, 50, or 60 times. In some embodiments, the device can be used more than 60 times. The device can also be used continuously or discontinuously for 1, 2, 3, 4, 5, 6, 7, or 8 hours. Cartridges used with the device can be disposed of after each use or can be used multiple times. Extended use of the device of the present invention provides the user with the advantage of not having to regularly clean the device or refill the fuel tank. The advantage of multiple use is preferably achieved by using a larger sized fuel tank and / or using butane as the fuel, which efficiently generates the temperature required for use of the device.

[0034] Typically, the operating temperature of the device is below 200°C. Often, the temperature required to aerosolize the product is about 100-200°C. In some embodiments, the temperature required to aerosolize the product is about 150°C. Once the product in the device is aerosolized, the aerosolized product is delivered to the user through a mouthpiece. In many cases, the devices of the invention are designed to mimic a smoking device such as a cigarette, pipe, or cigar holder.

[0035] In Figure 3, the device 300 includes a heater assembly 322 that can be powered by any combustible fuel, and a series of bimetallic objects 332 that control the flow of combustible fuel to the heater assembly 322. Examples of combustible fuels include, but are not limited to, propane, butane, methane, and ethanol. When the device 300 is heated, or a portion of the device 300 is heated, the bimetallic object 332 changes its shape (e.g., from flat to concave or convex) to control the amount of fuel that enters the heater assembly 322. This can occur by a variety of mechanisms, including pushing a rod 334 (referred to herein as a push rod 334) against a variable flow valve 336 shown in Figure 3.

[0036] A bimetallic object can be used to convert temperature changes into mechanical displacement. The object comprises two different metals, e.g., steel and copper, that expand at different rates when they are heated. The object can be an alloy or two metals fixed together. The bimetallic object can be any flat shape such as a square, rectangle, or strip. The bimetallic object is preferably a bimetallic disc. The differential expansion causes the flat object to curve in one direction when heated and in the opposite direction when cooled. The bimetallic object can be a bimetallic disc, e.g., a Truflex P675 / 700 disc available on the market.

[0037] The mechanical displacement of a bimetallic object is much greater than the small longitudinal stretch of either of the two metals. This effect is used in a wide variety of mechanical and electrical devices. In many exemplary devices of the invention, the bimetallic object is used in a flat configuration. In others it can be wound into a coil for compactness.

[0038] Nickel titanium (NiTi) is a shape memory alloy, commonly referred to as Nitinol. Above its transition temperature, Nitinol is superelastic and can withstand large deformations when a load is applied, returning to its original shape when the load is removed. Below its transition temperature, it exhibits a shape memory effect; when deformed, it retains that shape until it is heated above the transition temperature, at which point it returns to its original shape. Nitinol typically consists of about 55% nickel by weight. Small compositional changes can greatly alter the transition temperature of the alloy. These unique properties of Nitinol and its ability to be fine-tuned for use over a wide range of temperatures make it a suitable substitute for the bimetallic articles of the present invention. Those skilled in the art will appreciate that other shape memory alloys can be used without departing from the scope of the present invention.

[0039] The use of alternating stacked bimetallic disks in the device of the present invention is not only a simple and inexpensive solution to allocate a thermal regulation scheme in a very small space, but also has great advantages over other methods of thermal regulation. The disks are a modular solution, and different numbers of disks can be used to adjust the temperature sensitivity of the device. Using multiple disks instead of one disk allows for a longer overall travel for a given (small) diameter of the disk. Also, thinner or thicker disks can be used for the same purpose, or to add additional capacity to exert force. The dome-shaped disks are particularly strong, so fuel pressure changes have minimal effect on the temperature regulation. Also, because the bimetal stack is a continuous rather than discontinuous operating system, the device can have a gradual regulation effect by using the rough seating design described above, making the device less likely to self-extinguish. Also, because the disks respond to the temperature of the point of the device closest to the oven, the oven is maintained at the most stable temperature.

[0040] FIG. 4 shows a detailed embodiment of some of the components of the device 400 of the present invention. In FIG. 4, fuel is supplied to the tank 426 via a fill valve 428, and compressed liquid fuel can be withdrawn for use by a wick 438. In the embodiment of FIG. 5, the flow of gaseous fuel is restricted by a compressed foam flow restrictor 540 and can only be released via a valve orifice 542. There is a single elastomeric stopper 544 that inhibits the movement of gas. The use of a single stopper 544 for all gas flow regulation significantly enhances the simplicity and reliability of the system. Stopper 544 is also referred to herein as a variable flow valve 544. Also included may be a simple but independent means to regulate the flow of butane with temperature, to dispense a very small amount of gas flow to keep a portion of the catalyst above its extinguishing temperature, and to allow the user to turn the device 500 on and off. A variable flow valve allows all three of these needs to be operated with a single valve.

[0041] Stopper 544 may be connected to a solid jet assembly terminating in electrically insulated component 546. The jet assembly is typically held in a position allowing gas to exit valve orifice 542 and enter the jet assembly by a relatively low spring constant bias spring. Gas is limited to entering the jet assembly by sliding seal 550. Alternatively, a flexible diaphragm may be used. The user can block this normal gas flow by sliding the actuation slider so that the jet assembly is held down with stopper 544 sealing valve orifice 542, which is the off state of device 500. When the user allows normal gas flow by moving the actuation slider to the on position, the piezoelectric igniter is depressed causing a spark to be generated between jet rosette 552 and oven heater 522, thereby igniting the flowing gas. As the oven heater 522 begins to reach its operating temperature, a series of interleaved bimetallic disks 532 change shape (transitioning from flat to domed) acting on the push rod member 534 which presses against the jet assembly causing stopper 544 to restrict or stop the flow of gas.

[0042] By using a bimetallic disk design, the device of the present invention can be fine-tuned to a particular temperature control range by simply changing the distance between the disk backstop and the valve seat. In Figures 4 and 5, by threading the oven heater part 422, 522 into the plastic body 420, 520 of the device 400, 500, the operating temperature can be changed by simply twisting the oven part 422, 522 outward with a tool that fits into the oven. The oven 424 can also be designed to be manually moved by the user. A feature can also be built into the oven 422 to twist the part.

[0043] In FIG. 5, the push rod component 534 can have multiple functions. The push rod 534 can act to transfer the longitudinal motion of the bimetallic disc 532 to the jet assembly, which in turn transfers the motion to the valve stopper 544. The push rod 534 can also hold the catalyst in a simple assembly, such as by wrapping the catalyst around the push rod 534. The push rod 534 defines a fixed space between the jet rosette 552 and the catalyst, so that initial combustion can easily occur. In one embodiment, the push rod 534 has a generally dumbbell-like shape with two flat circular surfaces at opposite ends, which are used to contact the bimetallic disc 532 at the top and the insulating component 546 at the bottom. The lower end of the push rod 534 has a large cutout to allow gas flow through and for initial combustion to occur.

[0044] Many of the devices of the present invention use a temperature control mechanism in which a temperature regulator (a bimetallic disk) is placed near the area (in the oven) where temperature is most critical. Related art has typically placed temperature sensitive components in the flow valve, which is easily affected by the cold temperature of the expanding fuel gas and has less intimate contact with the vaporization chamber. Examples of related devices and methods are described in U.S. Patent Application 11 / 485,168, U.S. Patent No. 4,819,665, U.S. Patent No. 4,793,365, U.S. Patent No. 5,027,836, and PCT Application WO2006 / 082571. The adjustment mechanism of the devices of the present invention allows for fine tuning to a specific temperature with a simple twist of the oven.

[0045] 4 and 5, air enters the jet assembly via inlet holes 454, 554 and intersects with the butane flow path at venturi 556. Exhaust gases exit through outlet holes 458.

[0046] The user is prevented from touching hot internal elements by surrounding insulating features. The device of the present invention may include insulation to prevent the user from necessarily touching hot parts of the device. While greater insulating capacity is preferred so that the device operates at the best possible efficiency, the important point for the user is to perceive a relatively cool surface temperature. Various strategies can be used to address the user's perception of the device's temperature. The device can be wrapped with insulating material that is durable enough for external use. Materials for this purpose have low thermal conductivity and low heat capacity (specific heat). The combination of these properties results in very little heat being transferred to the user's fingers. Examples of materials with low thermal conductivity and capacity include some polymers and ceramics. Another strategy is to use isolation features to prevent the user from directly touching higher temperature areas. This minimizes the contact area between the user's fingers and the device, further lowering the perceived heat. The thermal conductivity and specific heat of the isolation features should be as low as possible.

[0047] The heater of the device of the present invention can include a conductive case and a catalyst, where the case can be one or more materials formed by welding or crimping together. The catalyst in the heater can be selected to provide efficient flameless combustion of the fuel. In some cases, to provide a visual cue to the user, when the heater is heating, the catalyst or heater can emit a color, such as red, to indicate that the device is on.

[0048] In some cases, the heater can be vented directly to the surrounding environment via a side hole. However, as shown in FIG. 1, the apparatus 100 of the present invention preferably incorporates a series of small holes 158 around the heater assembly 122, which better conducts heat from the catalyzed gas to the oven 124. Also, as shown in FIG. 6, the exhaust holes 662 in the plastic body 620 are positioned above the heater exhaust holes so that the exhausting gas must pass along the heater body, exchanging even more of its heat and improving the efficiency of the apparatus 600. The staggered exhaust holes, along with the use of two barriers (heater wall and body wall), have the added benefit of improving wind resistance (e.g., ambient wind is less likely to disrupt the internal flow of the gas or cool the catalyst to its extinguishing point). The particular geometry of the exhaust path allows these benefits without inhibiting the initial combustion of the gas necessary to initiate catalytic activity. The gas flows smoothly through a continuously expanding exhaust area without distorted detours that can cause the initial gas ignition to self-extinguish.

[0049] In the field of combustion catalysts, the light-off temperature is often used to describe the minimum temperature that a catalyst must maintain to catalyze the exothermic reaction of fuel and oxidant. Only a portion of the catalyst needs to remain at this temperature to prevent the reaction from stopping all together. The target operating temperature of the heater in the device of the present invention is close to the light-off temperature of most catalysts, making it difficult to maintain the catalyst. The target operating temperature of the heater can be 180°C. Examples of catalyst types used in the device of the present invention include, but are not limited to, platinum, palladium, and rhodium. The light-off temperature of the catalyst for use in the present invention can be about 100 to 200°C.

[0050] To accommodate small temperature differences in the heater compared to the extinguishing temperature, a small gas flow can be passed over the catalyst and / or the catalyst can be shielded from external factors such as wind. The device of the present invention can include a protected exhaust path so that the exhaust is not discharged directly into the outside air, but instead travels along a convoluted path, making the catalyst less susceptible to being extinguished by wind.

[0051] A reliability issue with the device of the present invention is maintaining the operation of the catalyst at the low target temperature of the device. A discontinuous on / off valve alone would be difficult to solve this problem because the cycle time of the butane burn interval often causes the catalyst to cool down too low, and the rapid burst of expanding butane actually acts to extinguish the catalyst due to the low temperature of the butane. A simple solution that can be incorporated into the device of the present invention is to slightly roughen the valve seat surface or use a rough stopper surface so that the device can obtain a small flow of butane just before completely closing off the flow during modulation. This is similar in operation to a needle valve, but is much cheaper and easier to implement. A needle valve can also be used with the device of the present invention to modulate the flow of fuel. Some prior art uses thermal mass to maintain the extinguishing temperature during the modulation interval. When gas flow is restored during the modulation interval, only the area in contact with the thermal mass initially catalyzes the gas and expels a reasonable amount of unused fuel. The device of the present invention does not require such a thermal mass because the valve seat acts as an analog valve, allowing the modulation interval and strength of the device to be small. The device of the present invention allows the small amount of butane needed to keep the catalyst above its extinguishing temperature, i.e., to keep the catalyst from extinguishing.

[0052] As shown in FIG. 3, the device 300 of the present invention can be used to aerosolize a material contained within a cartridge 370 that can be inserted into the furnace chamber 324 of the device 300. The gas is ignited by a spark from an igniter (shortly after gas flow begins) and heat begins to be conducted throughout the heater assembly 322. Heat is transferred to the cartridge 370 by conduction, convection, and / or radiation. The cartridge 370 can be shaped to fill the furnace chamber 324 to maximize surface contact for heat transfer. When the cartridge 370 is heated, vapor is generated within the cartridge 370 and in the space immediately above it. When the user inhales on the device 300, fresh air enters through the air inlet and mixes with the vapor, and the mixture is delivered to the user via the inhalation passageway. The air inlet or inlets can be oriented downward to improve drawing of vapor from the cartridge 370. Alternatively, the air inlet can be oriented above the cartridge 370, at an angle to the mouthpiece 310, or to the side of the case itself. The air inlet or inlets can have a diameter and orientation that allows ambient air to enter the chamber 324 and mix with the steam without affecting the operating temperature. The air inlet holes can also adjust the speed at which ambient air enters and mixes with the steam generated in the chamber 424, either at a set speed or at a speed selected by the user. For example, the speed of air entering the device 300 can give the user the perception that smoke is being drawn through a cigarette. Once the cartridge 370 has been used, the device 300 can be shut down and the cartridge 370 can be removed by opening the chamber 324 of the device 300. The cartridge 370 can be removed by hand or by a mechanism that allows the cartridge 370 to be removed quickly and easily. This mechanism can include the use of a pin or sliding parts that eject the cartridge 370 so that other parts of the device 300 can be moved or removed. The removal mechanism can also include the introduction of an external object.

[0053] The device shown in FIG. 7 can incorporate a mouthpiece 710 connected to the body 720 of the device 700. The mouthpiece 710 can be a hinged piece. Also, the mouthpiece 710 can be made to be securely fixed in place when it is closed onto the device body 720. The device 700 is intended to be used with a cartridge 770 of the present invention as described herein. The cartridge 770 can be inserted into the furnace chamber 724 of the device 700 of the present invention. As shown in FIG. 7, the mouthpiece 710 can be removed or hinged open to access the furnace chamber 724 and the cartridge 770 containing the material to be aerosolized can be inserted. Also, the mouthpiece 710 of the device 700 can be removable or removable for a single use configuration. In this way, multiple users can use the same device 700 but have a replaceable mouthpiece 710. Or, if the mouthpiece 710 becomes soiled, it can be easily replaced with another mouthpiece 710, avoiding the need to discard the entire device 700. When the device 700 incorporates a mouthpiece 710 connected to the body of the device, such as a hinged mouthpiece 710, the device 700 can be operated with one hand by a user.

[0054] The mouthpiece can be made from high temperature and food-safe materials such as ceramic, glass, or various high temperature plastics such as polyimide thermoplastics and polyetherimide (PEI) resins (trade name Ultem®). While the design is simplified by the use of high temperature materials, standard plastics or wood can also be used, with the addition of insulating components that prevent excess heat from reaching the user, e.g., the user's lips. Additionally, the length of the mouthpiece can be extended so that the temperature at the user's mouth is substantially lower than the end of the mouthpiece closer to the heat source.

[0055] The mouthpiece 710 of the device 700 of the present invention, such as the embodiment of Figure 7, can include a piercer for piercing a sealed cartridge containing material for use with the device 700. For example, one can open the hinged mouthpiece 710, insert the cartridge 770 into the device 700, and then close the mouthpiece 710 to pierce the cartridge 770 for use with the device 710. The piercer 712 can be any object apparent to one of ordinary skill in the art. The piercer 712 is preferably a small protrusion 712 molded into the mouthpiece 710 and terminating in a point or end 714 for piercing the cartridge 770 when a small force is applied.

[0056] Some related art devices require two hands for ignition, which the user experiences as awkward. Advantageously, the ignition method using the device of the present invention allows for one-handed ignition. As shown in Figures 8A and 8B, the user can press a button 802 on the device 800 to activate it and press the button 802 again to deactivate it. In other embodiments, the user can slide a string of material toward the mouthpiece end 810 of the device 800 to activate it and then slide the string back toward the fill port to deactivate it. As will be apparent to one of ordinary skill in the art, other components such as switches can be incorporated into the device of the present invention. A mechanical advantage is provided to the user to activate the igniter without the user exerting excessive force. Examples of mechanical advantage include, but are not limited to, levers, four-bar linkages, and other devices that will be apparent to one of ordinary skill in the art.

[0057] The device of the present invention may also provide additional user-friendly advantages. For example, a temperature regulating means consisting of a bimetallic object allows the device to be thin and compact, thus giving it an attractive shape. The insulation method protects the user from irritation due to high heat. A simple on / off mechanism allows the user to start and stop the operation using one hand.

[0058] II Cartridge FIG. 9 illustrates a cartridge 970 capable of containing a wet volatile product 972 (also sometimes referred to herein as a high viscosity volatile material, liquid volatile material, wet smokable material, fluid smokable material, or wet volatile content) for use with a device capable of vaporizing the product 970. In the figure, the cartridge 970 contains a case 974 sealed with a lid 976. In this embodiment, the case 974 includes a flange 978 for adhering the lid 976 to the case 974. The case 974 of the cartridge 970, or the entire cartridge 970, can be made from a variety of materials, including, but not limited to, metal, rigid plastic, flexible plastic, paper, paperboard, cardboard, and waxed paper. The case 974 of the cartridge 970 typically comprises a food-safe material, and the cartridge 970 is used with a device for inhalation of a substance by a person. Some food-safe materials include aluminum, stainless steel, polyethylene terephthalate (PET), amorphous polyethylene terephthalate (APET), high density polyethylene (HDPE), polyvinyl chloride (PVC), low density polyethylene (LDPE), polypropylene, polystyrene, polycarbonate, and many paper products. In some cases, particularly where the material is paper, the case 974 can be lined with a material or food-safe material to both prevent the volatile contents 972 from drying out when wet and to protect the volatile contents 972 when wet.

[0059] The cartridge is preferably shaped for easy insertion into the furnace of the apparatus of the present invention and fits snugly within the cavity of the furnace to improve heat transfer and evaporation. The cartridge can be formed and packaged by a process that avoids the production of large amounts of harmful gases.

[0060] The cartridge case can be capped, for example with a heat-sealable lidding film, to create a completely sealed, airtight cartridge. The sealed cartridge of the present invention can have the advantage of preserving the freshness of the contents and preventing spillage of materials within the cartridge during shipping or handling by the user.

[0061] The cartridge lid can be made from a variety of materials. Typically, the lid comprises a food-safe material. After the wet volatile contents are inserted into the cartridge of the present invention, the lid can be sealed onto the cartridge. Many methods of sealing the lid onto the cartridge case are known to those skilled in the art. One example of a method of sealing the lid onto the cartridge case including the flange is heat sealing. The cartridge lid is preferably considered food-safe up to at least about 400°F (204°C). The lid can be a commercially available film for use with foods cooked in a conventional oven, often referred to as dual ovenable (microwave and conventional oven use). Dual ovenable fills typically consist of a PET (polyethylene terephthalate) base layer and an APET (amorphous polyethylene terephthalate) heat sealing layer. These lid films can be easily metallized or preferably pre-foiled with aluminum to improve the barrier properties of the film against moisture, oxygen, and other gases. The metallized films can be manufactured by conventional conversion processes well known to those skilled in the art.

[0062] For purposes of illustration, Figure 10 shows a basic heat sealable film 1076 having a PET base layer 1080 and an APET heat sealing layer 1082. Figure 11 shows a composite film 1176 having a similar PET base layer 1180 and APET heat sealing layer 1182, but also having an additional metal layer 1184 and metal adhesive layer 1186. In both cases, the APET heat sealing layer 1182 is the one that contacts the flange of the case of the cartridge of the present invention.

[0063] The cartridge materials and cases of the present invention serve to preserve the freshness of the fill material and can increase the shelf life of the cartridge. Metallized cartridges, lids, and cases also enhance the visual appeal and perceived value of the cartridge. Cartridge materials can also enhance the printing and visibility of product information such as branding and scent indications.

[0064] Cartridges 1270 of the present invention containing a volatile product in a wet state can have holes or vents 1288 in the cartridge 1270, as shown in the exemplary cartridge 1270 of Figure 12. These holes 1288 allow the contents within the cartridge 1270 access to the environment. Some types of contents may require or find advantage in access to the environment.

[0065] 12 can be constructed from a material that can be perforated or opened when placed in a device that can vaporize the contents of the cartridge 1270. For example, when the cartridge 1270 is heated to a temperature, the contents vaporize and the hole or holes, or opening 1288 formed by the device allows the vapor contents to exit the heated cartridge 1270. In an alternative approach, the cartridge 1270 can include a lid or seal 1276 that can be opened just prior to inserting the cartridge 1270 into the device.

[0066] A portion of the cartridge can be that of Figure 13A, where the cartridge 1370 has two portions 1390, 1392 that can be secured together or have a mechanism for sealing the two portions 1390, 1392 together. Figure 13B shows the cartridge 1370 secured together, with each portion including a hole or vent 1388 for releasing vapor from the contents of the cartridge 1370 when the cartridge 1370 is heated.

[0067] In many cases, the cartridges of the present invention are intended to be disposable and easily disposed of, however, some cartridge types, such as those that have a method of sealing the two parts together, could be used multiple times as a reusable cartridge.

[0068] The cartridges may be provided or sold to end users containing a disposable moist volatile product. The type of product contained within the cartridge may be imprinted or written on the cartridge or may be indicated by the color, size, or shape of the cartridge. However, the cartridges may be filled with a moist volatile product at end use.

[0069] When intended for use by the end consumer, the sealed cartridge of the present invention can be inserted into the chamber of the device of the present invention. The mouthpiece of the device can then be returned to the closed position, at which point the film on the top of the cartridge can be pierced. Vapors generated by the heating process can exit the cartridge and be inhaled by the user via the mouthpiece.

[0070] III. Aerosolized Materials As will be apparent to those skilled in the art, any material that can be aerosolized and inhaled by the user can be incorporated into the device or cartridge of the present invention. It is particularly interesting for the material to provide an experience to the user in terms of a tactile response in the respiratory tract or in terms of visual feedback regarding the exhalation of the inhaled material. For example, many materials are contemplated for use with the present invention, including, but not limited to, tobacco, natural or artificial flavors, coffee grounds or beans, mint, Roman chamomile, lemon, honey, tea leaves, cocoa, and other plant-based non-tobacco alternatives. It is also contemplated that the device or cartridge of the present invention can be used with pharmaceutical or synthetic compounds for medicinal or recreational use interchangeably. Any of those compounds that can be evaporated (or volatilized) at relatively low temperatures without harmful degradation products are suitable for use with the cartridge or device of the present invention. Examples of compounds include, but are not limited to, menthol, caffeine, taurine, and nicotine.

[0071] The active ingredients contained in the plant vaporize at different temperatures. The device can be calibrated, for example, to establish a single stable temperature for vaporizing a particular product. The regulating means can be used to select different temperature settings. The user will select the setting based on the type of cartridge used. The regulating means can obtain the desired temperature mechanically, such as by varying the flow rate of a valve, or electronically, such as by an electromechanical valve and intermediate micro-regulating means. For example, to change the operating temperature of the device of the present invention, the chamber furnace can be moved relative to a temperature regulating means, such as a bimetallic disk.

[0072] Herein, tobacco or tobacco material is defined as any combination of natural and synthetic materials that can be vaporized for recreational or medical use. In one embodiment of the present invention, the cartridge can be prepared using cured tobacco, glycerin, and flavorings. Those skilled in the art of tobacco product manufacturing are familiar with these and other ingredients used in cigarettes, cigars, and the like. The cartridge can be prepared by breaking the tobacco into small pieces (e.g., less than 2 mm, preferably less than 1 mm), adding other ingredients, and mixing until uniformity is achieved. In another embodiment, the cartridge can be prepared by processing the fill material into a uniform paste (e.g., particle size less than 1 mm), which facilitates the process of filling the cartridge, for example, by using an auger filler, a peristaltic pump, or a piston pump.

[0073] Materials for use with the devices of the invention or contained within the cartridges of the invention preferably include at least one vapor forming medium and a medium for providing a tactile response in the respiratory tract of a user. The aerosolized product from materials inserted into the device can be a combination of vapor phase gas, as well as small liquid droplets that condense from the vapor phase and remain suspended in the gas / air mixture (the latter making up the visible portion of the inhaled substance).

[0074] Propylene glycol (PG), glycerin, or a combination of both can be used as the vapor-forming medium. Other vapor-forming media can be used with the cartridges and devices of the present invention. The vapor-forming medium, when heated, serves to produce a visible vapor, such as a smoky vapor. This vapor can be visualized both prior to inhalation and during exhalation of the medium. PG has several advantages over glycerin alone, since it exhibits a much higher vapor pressure at comparable temperatures, allowing the device to operate at lower temperatures. The reduced operating temperature can save energy and potentially further improve the health benefits of using this system.

[0075] In some cases, the vapor obtained from the PG inhaled by the user can be partially absorbed into the respiratory tract. When this occurs, the user appears to be mainly exhaling air. This differs from the traditional smoking experience in that, in the case of smoking, the user can typically enjoy seeing the smoke emitted as he or she exhales. Some preparations of the filler material of the present invention can include a combination of both glycerin and PG, since the visual vapor created by the heating of the glycerin can be seen upon exhalation. In these embodiments, the PG allows for a high density of visible vapor that the user can see / experience before inhalation as well as a tactile response in the respiratory tract, and the additional glycerin allows for an increased amount of vapor to be seen or experienced upon exhalation.

[0076] One method of producing the material for use in the device or cartridge of the present invention is to mix cured tobacco leaves with other ingredients at low temperature and then allow the mixture to be incorporated or marinated at room temperature for an extended period of time, anywhere from one day to as long as three weeks (depending on the particular formulation and flavor used). The material can then be processed by crushing to a uniform density with particles 1-2 mm in diameter, which can be inserted into the cartridge or directly into the device. Alternatively, the material can be further processed into a uniform paste to improve handling in the conventional pump device described herein.

[0077] Exemplary methods of filling the material into the cartridges included the auger filler method and the piston pump method, both of which are filling processes used in the packaging industry for food and pharmaceutical products. Either method allows a repeatable controlled volume (e.g., about 0.25 cubic centimeters) of fill material to be loaded into the case. The filled case can then be capped with a heat-sealable lidding film. The filling and sealing operations can be combined in an indexing device known to those skilled in the art of food and pharmaceutical packaging.

[0078] IV use The device mimics smoking by providing many of the desired effects of smoking that the user desires. An example of a method of using the device and / or cartridge of the present invention is shown in FIG. 14. The vapor-forming medium described herein can be mixed with tobacco material and inserted into the device 1400 of the present invention, either directly or using a cartridge of the present invention. The tobacco material provides the user with the inhalation of substances 1494 such as nicotine, but not many tar-type substances such as many Hoffman analytes (see below) that accompany the combustion of the tobacco material. The device 1400 of the present invention can be used in the same manner as a cigarette or other smoking device, by contacting the mouthpiece of the device 1400 with the mouth 12 of the user 10. However, without the smoke or the sensation of smoke, the user would not be satisfied with the experience. To provide a tactile response to the inhalation of tobacco material, a vapor-forming medium 1494 such as propylene glycol that can be absorbed into the respiratory tract 14 can be added.

[0079] Also, when smoking tobacco, the smoke can provide a visual aid and / or visual awareness to the user. To provide a similar visual aid, the vapor-forming medium can include a substance such as glycerin, which can be seen before and during inhalation, as well as during exhalation. In an exemplary method of use shown in FIG. 15, a user 10 receives tobacco material from the device 1500 of the present invention, which is inhaled with at least 70% reduction in the user's 10 Hoffman analyte intake. After ingestion of the material, the user can exhale visual vapor 1596 from the vapor-forming medium through the mouth 12. The visual vapor 1596 can provide the same visual aid as that of exhaled smoke in the act of smoking.

[0080] V Hoffman Analyte Cigarette smoke is a complex mixture of thousands of chemical components. Many of these are linked to smoking-related diseases. The Hoffman Analyte Table is a standard measure of the more harmful compounds found in cigarette smoke and recognizes approximately 44 different analytes present in the primary smoke. It is named in honor of Dietrich Hoffman, a biochemist and leading authority on tobacco carcinogenesis. This table includes chemicals commonly associated with the health risks of smoking. These analytes and chemicals include, for example, ammonia, aminonaphthalenes, benzopyrene, formaldehyde, acetaldehyde, acetone, methyl ethyl ketone, butyraldehyde, hydrogen cyanide, nitric oxide, tobacco-specific nitrosamines (TSNAs), pyridine, quinoline, hydroquinone, phenol, cresol, tar, nicotine, carbon monoxide, 1,3-butadiene, isoprene, acrylonitrile, benzene, toluene, styrene, and many others. In the primary smoke from smoking devices, several Hoffman analytes have been determined to be undesirable. Thus, extensive research has been conducted into the reduction of Hoffman analytes, which are also carcinogenic, making smoking or smoking-mimicking devices desirable.

[0081] The devices of the invention can be used to aerosolize tobacco material without burning the material. By aerosolizing tobacco, many undesirable chemicals and Hoffman analytes are not inhaled by the user. For example, the devices of the invention can reduce inhalation of Hoffman analytes by about 70% or more. In some embodiments, the devices of the invention can reduce inhalation of Hoffman analytes by about 50% or more. In some embodiments, the devices of the invention can reduce inhalation of Hoffman analytes by about 60% or more. In some embodiments, the devices of the invention can reduce inhalation of Hoffman analytes by about 70% or more. In some embodiments, the devices of the invention can reduce inhalation of Hoffman analytes by about 80% or more. In some embodiments, the devices of the invention can reduce inhalation of Hoffman analytes by about 90% or more.

[0082] VI Ames test The bacterial reverse mutation test was originally developed by Ames et al. The Ames test serves as a predictor of compounds that may cause carcinogenesis in humans. The method has been widely applied and the FDA has incorporated it as part of a more comprehensive study of new food additives and drugs. The same test has been widely used in toxicity studies of tobacco products and tobacco smoke. The Ames test is a biochemical test that evaluates the mutagenic potential of chemical compounds. Since cancer is often associated with DNA damage, the test also serves as a rapid test that predicts the carcinogenic potential of compounds. In comparison, standard tests for carcinogenicity performed in rodents take years to complete and are expensive. The Ames test uses several strains of Salmonella typhimurium that carry mutations in genes involved in histidine synthesis, so that they require histidine for growth. The variable tested is the mutagenic potential to induce reverse mutations to growth on a histidine-free medium. The test strains are specially constructed to carry both frameshift and point mutations in genes required for histidine synthesis, thus allowing the detection of mutations that act via different mechanisms. Some compounds are completely specific and induce reverse mutations in only one or two strains. Also, the test strains carry out mutations in genes responsible for lipopolysaccharide synthesis, making the bacterial cell wall more permeable and the test more sensitive in the excision repair system. Some compounds, such as benzopyrene, are not mutagenic in themselves, but their metabolic products are, so rat liver extracts are added to simulate the effects of metabolism. To carry out the test, bacteria are spread on maturation plates together with a small amount of histidine. This small amount of histidine in the growth medium allows the bacteria to grow and have the opportunity to carry out mutations during an initial period. When the histidine is gone, only those bacteria that have mutated to gain the ability to produce histidine survive. The plates are incubated for 48 hours. The mutagenicity of the substance is proportional to the number of colonies observed.

[0083] As shown in Example 2 below, devices of the present invention for use with tobacco-containing materials can exhibit significant improvements in Ames test results compared to smoking many types of tobacco. Thus, devices of the present invention can provide the user with many of the substances of tobacco, such as nicotine, without imparting some of the significant carcinogenic components associated with tobacco combustion or smoke. EXAMPLES

[0084] Cigarette smoke is a complex mixture of thousands of chemical components, many of which have been linked to smoking-related diseases. The Hoffman Analyte Table is a standard measure of the more harmful compounds found in cigarette smoke. 52 target compounds will be selected based on the Hoffman Table. It is expected that the vapor generated by the device of the present invention will reduce the levels of these target compounds by a significant amount (a reduction of 70% or more).

[0085] Testing of the components of the prototype device of the present invention and the reference cigarette (KY2R4F) is carried out in the laboratory. Samples from both device types are obtained on-site in an automatic smoking machine under Canadian strength regime (55 cubic centimeters (cc) puffs every 30 seconds). This method is believed to be closer to real smoking conditions than the FTC regime (35 cc puffs every 60 seconds). Arista has developed extensive records of the analysis of target compounds based on the literature. These records are used in the testing. The collection and extraction methods for each analyte group are summarized in Table 1.

[0086] [Table 1-1] [Table 1-2] [Table 1-3]

[0087] Five replicates of each target compound are tested for both the device of the present invention and the reference cigarette. The average difference between the two items is determined as a percentage. The device of the present invention is expected to reduce the levels of Hoffman analytes by about 70% or more compared to the reference cigarette. EXAMPLES

[0088] The bacterial reverse mutation test, or "Ames test," serves as a predictor of compounds that cause carcinogenesis in humans. This test has been used widely in toxicity studies of tobacco products and tobacco smoke. The purpose of the study described herein was to screen the smoke condensates of the present invention for mutagenicity in the TA98 strain of Salmonella typhimurium using the Ames test. Strain TA98 was selected because it is the most sensitive strain of Salmonella typhimurium and is capable of detecting a range of mutations. If a dose-dependent response is detected, the smoke condensate is considered mutagenic for that strain.

[0089] Test Facilities: Test article preparation (ie, "smoking" and extraction), chemical composition analysis and genotoxicity were performed at Arista Laboratories, 1941 Reymet Road, Richmond, VA. 23237.

[0090] Preparation of Test Article Extracts: Using the apparatus of the present invention connected to an automatic rotary smoking machine (Borgwaldt RM-20CSR), three cartridges were "smoked" per repetition using the following parameters: (1) puff volume of 55 ml, (2) puff duration of 30 seconds, and airflow according to ISO standards. The total particulate matter (TPM) phase was collected on a 44 mm Cambridge filter pad and extracted into dimethyl sulfoxide (DMSO). Immediately following extraction, the TPM samples were aliquoted into individual amber test bottles and stored at or below -70°C for at least 48 hours prior to Ames testing. Once dissolved and used for testing, the TPM extracts were not reused or refrozen.

[0091] Mutation Test (Ames Test): Ames tests were performed on TPM extracts generated during three independent "smoking" sessions. Tests were performed according to Arista Standard Operating Procedure#TOX001. TPM samples were tested in triplicate with the addition of exogenous metabolic activation system (S9). For each replicate, 10 concentrates of TPM particulate phase ranging from 0 to 2000 μg per plate were tested with a minimum of three plates per concentrate. Strain-specific positive control tests (with and without S9) and a single concentrate (i.e., 100 μg) of KY2R4F reference cigarette concentrate were run simultaneously. Tests were performed according to Canada Official Method 501, 2nd edition, 2004-11-01, Arista Standard Operating Procedure#TOX001. Ames test results are shown in Figure 16. The vehicle and positive control, KY2R4F, and spontaneous reversions that occurred concomitantly with the strains and culture conditions in each study were within expected laboratory control limits or were judged chemically acceptable by the study supervisor.

[0092] Results: As shown in FIG. 16, the study found no dose-dependent effects of total particulate matter (TPM) generated by "smoking" the device of the present invention. Furthermore, all TPM samples exhibited reversion mutation rates less than half those of the control studies. In contrast, published data for the "1R4F" Kentucky reference cigarette, regular tobacco cigarettes, and filter compositions had a positively sloping trend for the TA98 test strain. See DW Bombick et al., "Chemical and Biological Studies of a New Cigarette that Primarily Heats Tobacco, Part 3, In Vitro Toxicity of Whole Smoke," Food and Chemical Toxicology, 36:183-190 (1997).

[0093] Although preferred embodiments of the present invention have been shown and described in detail herein, it will be apparent to those skilled in the art that the embodiments are provided by way of example only. Numerous variations, changes, and substitutions will occur to those skilled in the art without departing from the invention. It should be understood that various alternatives to the embodiments of the invention described herein may be employed in practicing the invention. The following claims define the scope of the invention, and it is intended that methods and structures within the scope of these claims and their equivalents be covered thereby.

Claims

1. 1. A cartridge for use with a vaporizer, the vaporizer including a chamber configured for the cartridge to be inserted therein, the cartridge comprising: a case containing a volatile material having glycerin and a tobacco material including tobacco strips; a lid connected to an end of the case and separate from the case, the lid including a plurality of holes or exhaust ports; the plurality of holes or vents in the lid are configured to allow for the exhaust of an aerosol generated when the volatile material in the cartridge is heated to a target temperature by a heater in the vaporizer; The cartridge, wherein the glycerin is present in an amount to produce a visible aerosol.

2. A cartridge as described in claim 1, wherein the case includes a flange for adhering the lid to the case.

3. A cartridge as described in claim 1, wherein the lid comprises a film having multiple layers including a base layer, a heat sealing layer on one side of the base layer, and a metal layer on the other side of the base layer.

4. 2. The cartridge of claim 1, wherein the tobacco strips are less than 2mm in diameter.

5. The cartridge of claim 1 , wherein the target temperature is between 100° C. and 200° C.

6. The cartridge of claim 1 , wherein the lid is sealed to the case.

7. The cartridge of claim 1 , wherein the lid comprises a heat-sealable film or aluminum.

8. The cartridge of claim 1 , wherein the volatile material is a liquid volatile material or a high viscosity volatile material.

9. The main body, a cartridge configured to be inserted into the body, The cartridge comprises: a case containing a volatile material having glycerin and a tobacco material including tobacco strips, a heater configured to heat the volatile material in the cartridge within the body to a target temperature; a lid connected to an end of the case and separate from the case, the lid including a plurality of holes or vents configured to allow an aerosol generated by heating the volatile material in the cartridge to exit the cartridge; The aerosol generating device, wherein the glycerin is present in an amount to produce a visible aerosol.

10. An aerosol generating device as described in claim 9, wherein the case includes a flange for adhering the lid to the case.

11. The aerosol generating device of claim 9, wherein the lid comprises a film having multiple layers including a base layer, a heat sealing layer on one side of the base layer, and a metal layer on the other side of the base layer.

12. 10. The aerosol generating device of claim 9, wherein the tobacco strips are less than 2 mm in diameter.

13. 10. The aerosol generating device of claim 9, wherein the target temperature is between 100°C and 200°C.

14. The aerosol generating device of claim 9 , wherein the lid is sealed to the case.

15. 10. The aerosol generating device of claim 9, wherein the lid comprises a heat-sealable film or aluminum.

16. The aerosol generating device according to claim 9 , wherein the volatile material is a liquid volatile material or a high-viscosity volatile material.

Images