Skin preparations

Abstract

The present invention addresses the problem of obtaining a composition that contains niacinamide and is not sticky, provides an excellent feeling of penetration, and also gives an excellent feeling of firmness after use. The external preparation for skin that solves this problem is an external preparation for skin that contains the following components (A)-(D): (A) 1-10 mass% niacinamide, (B) a cationic surfactant, (C) an anionic polymer, and (D) water.

Description

[Technical field]

[0001] The present invention relates to an external skin preparation containing niacinamide, and more particularly to an external skin preparation which has excellent stability even when it contains a cationic surfactant and an anionic polymer. [Background technology]

[0002] The skin develops spots, wrinkles, sagging, pigmentation, etc. due to internal factors such as aging and stress, and external factors such as ultraviolet rays and dry air. In particular, morphological changes such as wrinkles and sagging have a large impact on the impression of the skin's appearance, so many people wish to improve them. Many active ingredients have been proposed to prevent and improve these wrinkles and sagging, and among them, niacinamide is known to be highly safe and to have an anti-aging effect on the skin (see, for example, Patent Documents 1 and 2). However, it is also known that when a large amount of niacinamide is contained, it has an undesirable feel when used, such as a strong sticky feeling, and improvements have been made (see, for example, Patent Document 3).

[0003] On the other hand, in cosmetics and skin external preparations that are applied topically to the skin and hair, efforts have been made to improve the permeability of active ingredients into the tissue. One of the means is the use of electric charges in the composition. It is believed that the skin surface is negatively charged, and cationic substances with positive charges are known to have high adsorption and permeability to the skin. Therefore, in order to improve the adsorption and permeability of active ingredients to biological tissues, cosmetics containing cationic polymers (see, for example, Patent Documents 4 and 5) have been provided. However, when an anionic substance is used in combination, a complex is formed in the composition, causing problems such as clouding, and the generation of aggregates and lumps. Another means for improving the permeability of active ingredients is the use of vesicle particles, and a vesicle composition containing a cationic surfactant that combines these two means is also known (see, for example, Patent Document 6). [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Publication No. 10-130135 [Patent Document 2] Japanese Patent Application Publication No. 10-001414 [Patent Document 3] Special Publication No. 2003-502435 [Patent Document 4] JP 2016-108344 A [Patent Document 5] International Publication No. 2019 / 111415 Brochure [Patent Document 6] International Publication No. 2014 / 069631 Brochure Summary of the Invention [Problem to be solved by the invention]

[0005] Therefore, the present invention aims to develop a technology that contains a cationic surfactant with excellent skin permeability, but also has good stability by suppressing and mitigating aggregations caused by electrical interactions, and can be used in combination with various anionic substances. Another objective of the present invention is to provide an external skin preparation that does not feel sticky when used even when a large amount of niacinamide is blended as an active ingredient, has excellent skin permeability, and provides an excellent finish feeling such as a firm feeling on the skin after use. [Means for solving the problem]

[0006] Therefore, the present inventors conducted extensive research to solve the above problems and discovered that the use of niacinamide in a composition containing a cationic surfactant and an anionic polymer alleviates aggregation caused by electrical interaction between the cationic surfactant and the anionic polymer, thereby completing the present invention.

[0007] That is, the present invention provides the following components (A) to (D): (A) Niacinamide 1 to 10% by mass (B) Cationic surfactant (C) Anionic polymer (D)Water The present invention provides an external skin preparation containing the above compound. Effect of the Invention

[0008] According to the present invention, by using niacinamide together, it is possible to suppress the occurrence of precipitation due to the electrical interaction between cationic surfactant and anionic polymer.In addition, the skin external preparation of the present invention is not sticky when used, has excellent skin penetration, and has excellent finish effect such as firmness of the skin after application.In addition, the skin external preparation is excellent in stability, so it can be used for a long period of time, and is useful as a cosmetic that can improve skin elasticity and prevent and improve morphological changes due to aging such as wrinkles and sagging, and can be expected to have anti-aging effects. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0009] The present invention will be described in detail below. In this specification, the symbol "to" means a range including the numerical values ​​before and after it. The component (A) niacinamide used in the present invention is an amide compound of nicotinic acid (vitamin B3 / niacin). Niacinamide is a water-soluble vitamin and a known substance that is one of the vitamin B group, and can be extracted from natural products (such as rice bran) or synthesized by known methods. Specifically, those listed in the 17th revised Japanese Pharmacopoeia can be used.

[0010] The content of component (A) in the present invention is 1 to 10% by mass (hereinafter, simply "% by mass" will be abbreviated as "%"), preferably 3 to 10%, and particularly preferably 4 to 9%. If the content of component (A) is less than 1%, firmness and the like may not be obtained, whereas if it exceeds 10%, the product may feel sticky when applied and may have a poor feel when used.

[0011] The cationic surfactant, component (B) used in the present invention, improves the penetration and skin compatibility of a topical skin preparation by taking advantage of its adsorption to the skin, and is not particularly limited as long as it is used in ordinary cosmetics, topical skin preparations, etc., and any of them can be used. Examples of component (B) include amine salts such as alkylamine salts, polyamines, and amino alcohol fatty acid derivatives, alkyl quaternary ammonium salts, aromatic quaternary ammonium salts, pyridium salts, and imidazolium salts. Examples of the quaternary ammonium salts include cetyltrimethylammonium chloride, cetyltrimethylammonium bromide, stearyltrimethylammonium chloride, stearyltrimethylammonium bromide, behenyltrimethylammonium chloride, behenyltrimethylammonium bromide, behenyltrimethylammonium methylsulfate, distearyldimethylammonium chloride, dioleyldimethylammonium bromide, cetylbehenyldimethylammonium methylsulfate, stearyldimethylbenzylammonium chloride, dipalmitoylethylhydroxyethylmonium methosulfate, dicocoylethylhydroxyethylmonium methosulfate, and distearoylethylhydroxyethylmonium methosulfate. One or more of these can be selected.

[0012] In addition, the component (B) of the present invention may be a skeleton of an amphoteric surfactant, so long as it has cationicity in the composition. Such surfactants are preferably those having an amino acid residue, and preferably the amino acid residue is a basic amino acid residue. Specific examples include mono-N-long chain acyl basic amino acid lower alkyl ester salts such as stearoyl lysine butyl ester hydrochloride, N-cocoyl-L-arginine ethyl ester pyrrolidone carboxylate, lauroyl-ornithine propyl ester acetate, and guanidine derivatives such as decyl guanidine acetate, 2-guanidinoethyl laurylamide hydrochloride, and 2-guanidinobutyl stearamide DL-pyrrolidone carboxylate, and one or more of these may be selected. In addition, examples of these salts include halogens, methosulfates, ethosulfates, and methophosphates.

[0013] Among these, from the viewpoint of stability, quaternary ammonium salts and mono-N-long chain acyl basic amino acid lower alkyl ester salts are preferred, and among the quaternary ammonium salts, alkyltrimethylammonium chloride, di-long chain acylalkylhydroxyalkylammonium, and mono-N-long chain acyl basic amino acid lower alkyl ester salts, N-cocoyl-L-arginine ethyl ester pyrrolidone carboxylate is preferred. More specifically, a mixture with other aqueous components may be used, and examples of such commercially available products include GENAMIN KDMP (Clariant Japan: 81.5% pure), which is a mixture of behentrimonium chloride, DEHYQUART L80 T (BASF: 80% pure), which is a mixture of dicocoyl ethyl hydroxyethylmonium methosulfate, DEHYQUART AU56 / G and DEHYQUART C4046 (BASF), which are mixtures of dipalmitoyl ethyl hydroxyethylmonium methosulfate, and CAE (Ajinomoto Co., Inc.), which is N-cocoyl-L-arginine ethyl ester pyrrolidone carboxylate. Among these, a two-chain surfactant such as a di-long chain acyl alkyl hydroxyalkyl ammonium is particularly preferable because it can form vesicle particles by itself, thereby improving skin permeability and providing excellent stability over time.

[0014] The content of component (B) in the present invention is preferably about 0.001 to 0.1%, more preferably 0.002 to 0.05%, and particularly preferably 0.02 to 0.05%, from the viewpoints of skin penetration and safety.

[0015] In the present invention, the content mass ratio (A) / (B) of component (A) to component (B) is not particularly limited, but from the viewpoint of usability as an external skin preparation, it is 10 to 500, preferably 25 to 300, and more preferably 25 to 200. Within this range, there is no stickiness during use, and the skin feels more penetrated and firm after use.

[0016] The anionic polymer of component (C) used in the present invention is not particularly limited as long as it is a polymer having anionic properties and is generally used as a cosmetic.Specific examples include water-soluble polymers such as alginic acid, hyaluronic acid, gum arabic, carrageenan, chondroitin sulfate, gelatin, carboxymethylcellulose, carboxyvinyl polymer, polyacrylic acid, and their derivatives, and one or more of these can be used.In addition, these are not particularly limited by their origin, such as natural or synthetic.

[0017] Among these, in the present invention, carboxyvinyl polymer and / or alkyl-modified carboxyvinyl polymer are preferred from the viewpoint of excellent firmness of the skin after use without stickiness. Here, "carboxyvinyl polymer" is a general term for polymers containing polymerizable monomers having at least a polymerizable vinyl group and a carboxyl group or an alkyl-modified carboxyl group as a constituent unit. Here, "alkyl-modified" means that a part or all of the carboxyl group is alkyl esterified, and for example, a polymer containing at least one acrylic acid ester or methacrylic acid ester as a constituent monomer is included in the example of alkyl-modified carboxyvinyl polymer. The number of carbon atoms of the alkyl-modified alkyl group is not limited, but is preferably 10 to 30, more preferably 18 to 24. Commercially available alkyl-modified carboxyvinyl polymers include CARBOPOL 1342 and CARBOPOL 1382 (both manufactured by LUBRIZOL ADVANNCED MATERIALS), Pemulen TR-1 and Pemulen TR-2 (both manufactured by NOVEON), and commercially available carboxyvinyl polymers include CARBOPOL 940, CARBOPOL 941, CARBOPOL 980 and CARBOPOL 934 (both manufactured by LUBRIZOL ADVANNCED MATERIALS), and AQUPEC HV-501 (manufactured by Sumitomo Seika Chemicals).

[0018] The amount of component (C) in the present invention is not particularly limited as long as it is an amount normally used in cosmetics, but from the viewpoint of interaction with component (B), it is preferably in the range of 0.001 to 10%, more preferably 0.01 to 5%, more preferably 0.05 to 1%, and particularly preferably 0.05 to 0.2%. Within this range, it is possible to provide an external skin preparation that is excellent in stability, non-stickiness during use, and firmness of the skin after use.

[0019] In the present invention, the content mass ratio (A) / (C) of component (A) to component (C) is not particularly limited, but is 5.0 to 150, preferably 5.0 to 125, and more preferably 10 to 100. If it is within this range, the product will not be sticky and will have a better firmness after application. Furthermore, the content mass ratio (B) / (C) of component (B) to component (C) is not particularly limited, but is preferably 0.01 to 10, more preferably 0.05 to 5, even more preferably 0.1 to 1, and particularly preferably 0.2 to 0.6. If it is within this range, the aggregation suppression effect will be better.

[0020] The water (D) component used in the present invention is not particularly limited as long as it is generally used in cosmetics, etc. In addition to purified water, deep sea water or steam-distilled water from plants such as rose water and lavender water may be used within a range that does not impair the effects of the present invention, and one or more types may be appropriately selected and used as necessary. The amount of component (D) in the present invention is not particularly limited as long as it is an amount normally used in cosmetics, but is preferably 30 to 95%.

[0021] Furthermore, in the present invention, when a hydrophilic nonionic surfactant is used as component (E), aggregation of components (B) and (C) can be suppressed. Component (E) is a nonionic surfactant with an HLB of 10 to 18, and more preferably one with an HLB of 11 to 16. The HLB (hydrophile-lipophile balance) value used in the present invention is a value obtained by the Griffin method. Specifically, polyglycerin fatty acid ester, sucrose fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbit fatty acid ester, polyoxyethylene glycol fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene hydrogenated castor oil, polyoxyethylene fatty acid ethanolamide, polyoxyethylene cholesterol ether, polyoxyethylene cholestanol ether, polyoxyethylene phytosterol ether, polyoxyethylene phytostanol ether, polyoxyethylene alkyl ether, propylene glycol fatty acid ester, polyoxyalkylene modified silicone, polyoxyalkylene alkyl co-modified silicone, etc. can be mentioned, and one or more of these can be used. Among them, nonionic surfactants having a polyoxyethylene group are preferred, and nonionic surfactants having an average addition mole number of ethylene oxide of 5 to 100 are preferred, and 10 to 80 are more preferred.

[0022] As the component (E), commercially available products can be used, for example, RHEODOL TW-O120V (manufactured by Kao Corporation) which is polyoxyethylene sorbitan monooleate (20 E.O.), NONION OT-221 (manufactured by NOF Corporation), RHEODOL TW-S120V (manufactured by Kao Corporation) which is polyoxyethylene sorbitan monostearate (20 E.O.), NONION ST-221 (manufactured by NOF Corporation), NIKKOL PEN-4620 (manufactured by Nikko Chemicals Co., Ltd.) which is polyoxyethylene polyoxypropylene decyl tetradecyl ether (20 E.O.), EMALEX PS-30 (manufactured by Nippon Emulsion Co., Ltd.), NIKKOL BPS-30 (manufactured by Nikko Chemicals Co., Ltd.), EMALEX HC-60 (manufactured by Nippon Emulsion Co., Ltd.) which is polyoxyethylene hydrogenated castor oil (60 E.O.), NIKKOL Examples of such silicones include HCO-60 (manufactured by Nikko Chemicals Co., Ltd.), polyoxyalkylene-modified organopolysiloxanes such as KF-6011, KF-6011P, KF-6018, and KF-6043 (all manufactured by Shin-Etsu Chemical Co., Ltd.), and NUC Silicone SS-2802 (manufactured by Dow Corning Toray Co., Ltd.).

[0023] The content of component (E) in the present invention is not particularly limited, but is preferably 0.01 to 10%, more preferably 0.05 to 8%, more preferably 0.1 to 6%, and particularly preferably 0.5 to 6%. Within this range, aggregation of components (B) and (C) is further suppressed, and a skin topical preparation that is stable over a long period of time can be obtained.

[0024] In the present invention, the ratio (E) / [(B)+(C)] of component (E) to the total mass content of components (B) and (C) is not particularly limited, but is 0.1 to 150, preferably 0.5 to 100, and more preferably 1.0 to 80, from the viewpoints of the effect of inhibiting aggregation of components (B) and (C) and of providing a good non-sticky feeling and good penetration feeling during use.

[0025] Furthermore, in the present invention, component (B) constitutes vesicle particles, and thus not only the adsorptivity due to electric charge but also the permeability as a skin external preparation is improved, and the effects of component (A) and other active ingredients are more synergistically exhibited. As described above, if the surfactant of component (B) is a two-chain type, it can form a vesicle by itself, or it may be used in combination with other vesicle membrane constituents such as phospholipids or sodium dilauroyl glutamate lysine to form vesicle particles containing a cationic surfactant. Among these, phospholipids can be preferably used from the viewpoint of safety. In addition, the method of forming vesicle particles is not particularly limited, and they can be produced by conventional methods, and the method of confirming vesicle particles can be performed by the presence or absence of Maltese cross images under crossed Nicols using a polarizing microscope. When phospholipids are used, the content of phospholipids is not particularly limited, but is preferably 0.01 to 5%, more preferably 0.05 to 1%, and particularly preferably 0.1 to 0.5%.

[0026] The pH of the external skin preparation of the present invention is not particularly limited, but the pH at 25°C is preferably within the range of 4.0 to 7.5.

[0027] In addition to the above-mentioned components (A) to (E), the skin external preparation of the present invention may contain appropriate components used in ordinary skin external preparations, provided that the effects of the present invention are not impaired. For example, it may contain oils such as higher alcohols, hydrocarbon oils, ester oils, waxes, and silicone oils, aqueous components such as surfactants, water-soluble polymers, polyhydric alcohols, and lower alcohols, ultraviolet absorbers, antioxidants, antibacterial agents, preservatives, moisturizers, pH adjusters, cooling agents, powders, vitamins, beauty ingredients, and fragrances. One embodiment of a preferred composition of the external skin preparation of the present invention is as follows. Component Preferred More preferred Further preferred Especially preferred (A) 1~10% 3~10% 4~9% 4~9% (B) 0.001~0.1% 0.002~0.05% 0.02~0.05% 0.02~0.05% (C) 0.001~10% 0.01~5% 0.05~1% 0.05~0.2% (D) 30~95% 30~95% 30~95% 30~95% (E) 0.01~10% 0.05~8% 0.1~6% 0.5~6%

[0028] The method for producing the skin external preparation of the present invention is not particularly limited, and it can be prepared by a conventional method. For example, the skin external preparation can be prepared by adding and mixing the component (B) and other components as necessary, which are dissolved by heating, to the components (A) and (C) to (E) which are uniformly dissolved and mixed, and further adding the above-mentioned optional components as necessary, and mixing them.

[0029] The skin topical preparation of the present invention can be implemented in various forms such as liquid, gel, cream, etc., and the dosage form is not particularly limited, and may be a solubilized type, an oil-in-water type, a water-in-oil type, an oily type, a water-in-oil-in-water type, an oil-in-water-in-oil type, a multi-layer type, etc. From the viewpoint of stability, a low viscosity or translucent form is preferable because the effect of the present invention can be realized.

[0030] The skin external preparation of the present invention can be used as a skin cosmetic, and examples of such cosmetic include lotion, milky lotion, cream, beauty essence, massage agent, pack agent, hand cream, body lotion, body cream, sunscreen, foundation, eye shadow, eye liner, concealer, scalp treatment, etc. In terms of being able to realize the effect, skin care cosmetic is preferable, and the method of use thereof includes a method of using it on hands, fingers, or cotton, a method of using it by impregnating nonwoven fabric, etc., a method of using it by directly spraying, etc. In a preferred embodiment of the skin external preparation of the present invention, for example, hair cosmetic products that are applied exclusively to hair, such as shampoo, rinse, conditioner, hair wax, etc., can be excluded. EXAMPLES

[0031] Examples are given below to specifically explain the present invention, but the present invention is not limited to these examples, etc. Furthermore, unless otherwise specified, the content is shown in mass% relative to the composition in which the component is contained.

[0032] Examples 1 to 11 and Comparative Examples 1 to 4: Cosmetic Serum A beauty essence having the composition shown in Table 1 was produced by the manufacturing method described below, and was evaluated and judged by the following methods for A: aggregation suppression effect, B: penetration feeling, C: non-stickiness, and D: firmness of the skin after application. The results are also shown in Table 1.

[0033] [Table 1]

[0034] (Manufacturing method) A: Components (1), (2), (5) to (11), and (16) were heated and dissolved uniformly at 75°C. B: Components (3), (4), (12) to (15) were heated to 75°C to form a homogeneous solution. C: A was added to B at 75°C and stirred to obtain a beauty essence.

[0035] (Evaluation method 1) (a) Aggregation Inhibition Effect The aggregation-inhibiting effect was evaluated based on the transparency when the beauty essences of Examples 1 to 11 and Comparative Examples 1 to 4 were diluted 10 times with water. It was confirmed that the transparency ensures long-term stability. 1.0g of each composition was weighed out and placed in a glass beaker, diluted 10 times with purified water, and stirred until a uniform solution was obtained. At that time, the mixture was stirred by hand using a metal spatula. The obtained sample was filled into a glass cell with an optical path length of 10mm and an optical path width of 5mm, and the transmittance at a wavelength of 700nm was measured using a spectrophotometer (UV-2500PC, manufactured by SHIMADZU). <Judgment criteria> (Judgment): (Evaluation) ◎: Transmittance is 55% or more (no aggregation or precipitation after storage at room temperature for 1 month) △: Transmittance is 45-55% (After storing at room temperature for one month, some aggregation, precipitation, and turbidity change are observed.) ×: Transmittance is less than 45% (After storage at room temperature for one month, aggregation, precipitation, and changes in turbidity are observed.)

[0036] (Evaluation method 2) Ten expert panelists were selected from women in their 20s to 40s who had been trained in sensory evaluation and could evaluate using a certain standard. The expert panelists used each sample on their forearms, and for each sample, they rated and scored the following absolute evaluation on a 5-point scale for the feeling of penetration, non-stickiness, and firmness of the skin after use. For each sample, the average score was calculated from the total scores of all panelists, and the score was judged according to the following 4-point scale.

[0037] (B: Penetration) <Absolute evaluation criteria> (Score):(Evaluation) 5 points: I feel like the lotion penetrates into my skin. 4 points: I feel like the lotion is absorbed into my skin. 3 points: Average 2 points: I don't feel like the lotion penetrates into my skin very much. 1 point: I don't feel like the lotion penetrates into my skin. <4-level evaluation criteria> (The same applies to the following evaluation items) (Judgment): (Average score) ◎: 4.5 points or more: Very good ○: 3.5 points or more and less than 4.5 points: Good △: 1.5 points or more and less than 3.5 points: slightly poor ×: Less than 1.5 points: Defective

[0038] (H: Non-stickiness) <Absolute evaluation criteria> (Score):(Evaluation) 5 points: No sticky feeling 4 points: Almost no stickiness 3 points: Slightly sticky feeling 2 points: Sticky feeling 1 point: Very sticky feeling

[0039] (2: Firmness of the skin after treatment) <Absolute evaluation criteria> (Score):(Evaluation) 5 points: Skin feels firmer 4 points: Skin feels a little firmer 3 points: Average 2 points: I don't feel like my skin is very firm. 1 point: I don't feel like my skin is firm.

[0040] As is clear from the results in Table 1, the serums of Examples 1 to 11 were superior to the serums of Comparative Examples 1 to 4 in terms of aggregation suppression effect, penetration feeling, non-stickiness, and firmness of the skin after application. On the other hand, Comparative Example 1, which does not contain component (A), was inferior in the firmness of the skin after application. Comparative Example 2, which replaced component (A) with another skin benefit agent (dipotassium glycyrrhizinate), was inferior in the aggregation suppression effect, lack of stickiness, and firmness of the skin after application. Comparative Example 3, which contains 0.5% component (A), also did not leave the skin feeling firm after application, and Comparative Example 4, which contains 15% component (A), was difficult to feel the penetration of the product due to the excessive amount of niacinamide, and was sticky.

[0041] Example 12: Lotion (Component) (%) (1) Alkyltrimethylammonium chloride (Note 2) 0.1 (2) Hydrogenated soybean phospholipid (Note 7) 0.5 (3) 1,3-butylene glycol 5.0 (4) Polyoxyethylene sorbitan monooleate (20E.O.) 1.0 (5) Appropriate amount of fragrance (6) Ethanol 10.0 (7) Preservatives (appropriate amount) (8) Niacinamide 5.0 (9) Tranexamic acid 2.0 (10) Polyoxyethylene glycerin (26E.O.) 2.0 (11) Polyoxyethylene methyl glucoside (Note 8) 2.0 (12) (Acrylates / Alkyl acrylates (C10-C30)) Crosspolymer (Note 3) 0.1 (13) Carboxyvinyl polymer 0.1 (14) Sodium hydroxide 0.05 (15) Remaining purified water (Note 8) MacbioBride MG-10E (NOF Corporation)

[0042] (Manufacturing method) A: Components (1) to (3) are homogeneously dissolved and mixed at 75°C. B: While maintaining A at 75°C, a portion of component (15) is added and stirred with a dispers mixer to obtain a vesicle dispersion. C: Components (4) to (15) are uniformly dissolved and mixed at room temperature. D: The above B cooled to 35° C. was added to the above C and mixed to obtain a lotion. The lotion obtained in the above manner was excellent in the aggregation suppression effect, penetration feeling, non-stickiness, and firmness of the skin after application.

[0043] Example 13: Transparent lotion (Component) (%) (1) Polyoxyethylene isostearate (50) Hydrogenated castor oil 0.2 (2) PEG-10 methyl ether dimethicone (Note 4) 0.1 (3) Dicocoyl ethyl hydroxyethylmonium methosulfate 0.01 (4) Alkyltrimethylammonium chloride 0.01 (5) Ethyl oleate 0.05 (6) Cetyl 2-ethylhexanoate 0.05 (7) Flavoring (appropriate amount) (8) Ethanol 1.0 (9) 1,3-butylene glycol 5.0 (10) Glycerin 5.0 (11) Diglycerin 2.0 (12) Polyoxybutylene, polyoxyethylene, polyoxypropylene Glyceryl Ether (3E.O.) (Note 9) 3.0 (13) Niacinamide 5.0 (14) Carboxyvinyl polymer 0.1 (15) Sodium hydroxide 0.05 (16) Tranexamic acid 1.0 (17) Sodium hydroxide 0.05 (18) Preservatives (appropriate amount) (19) Flavoring (appropriate amount) (20) Remaining purified water (Note 9) Wilbride S-753D (manufactured by NOF Corp.)

[0044] (Manufacturing method) A: Components (1) to (10) are homogeneously dissolved and mixed at 70°C. B: Components (11) to (20) are uniformly dissolved and mixed at room temperature. C: The above-mentioned A was added to B, and solubilized at room temperature to obtain a transparent lotion. The transparent lotion obtained in this manner was excellent in the aggregation suppression effect, penetration feeling, non-stickiness, and firmness of the skin after application.

[0045] Example 14: Oil-in-water emulsion type serum (Component) (%) (1) Polyglyceryl-10 (eicosanedioic acid / tetradecanedioic acid) 1.5 (2) Tripropylene glycol 15.0 (3) Niacinamide 6.0 (4) L-theanine 0.05 (5) 1,3-butylene glycol 3.5 (6) Dipropylene glycol 0.5 (7) Remaining amount of purified water (8) Glycerin 2.0 (9) Polyethylene glycol 2.0 (10) Tranexamic acid 2.0 (11) Sodium hydrogen phosphate 0.3 (12) Sodium dihydrogen phosphate 0.6 (13) Disodium edetate 0.02 (14) Methylparaben 0.1 (15) Polyoxyethylene isostearate (50) Hydrogenated castor oil 0.2 (16) Polyoxyethylene (60) Hydrogenated castor oil 0.2 (17) Dicocoyl ethyl hydroxyethylmonium methosulfate 0.01 (18) Ethanol 5.0 (19) L-Menthol 0.02 (20) Isopropyl myristate 0.3 (21) Dimer dilinoleic acid (phytosteryl / isostearyl / cetyl) / Stearyl / Behenyl) (Note 10) 0.2 (22) Sorbitan oleate 0.2 (23) Tocotrienol 0.02 (24) Carboxyvinyl polymer 0.02 (25) (Acrylates / Alkyl acrylate (C10-30)) Crosspolymer (Note 3) 0.02 (26) Xanthan gum 0.01 (27) Sodium hydroxide 0.01 (28) Hydrolyzed hyaluronic acid 0.01 (Note 10) PLANDOOL-S (manufactured by Nippon Fine Chemicals)

[0046] (Manufacturing method) A: Mix components (1) to (14) uniformly at room temperature. B: Components (15) to (23) are uniformly dissolved and mixed at 70°C. C: Add B to A and emulsify at 70°C. D: After cooling C to 40° C., ingredients (24) to (28) were added and mixed uniformly to obtain a beauty essence. The oil-in-water emulsion type beauty essence obtained in the manner described above was excellent in terms of the aggregation suppression effect, penetration feeling, non-stickiness, and firmness of the skin after application.

[0047] Example 15: Sunscreen (oil-in-water type) (Component) (%) (1) 1,3-butylene glycol 5.0 (2) Dipropylene glycol 5.0 (3) Behentrimonium chloride 0.1 (4) Hydrogenated lecithin (Note 11) 0.5 (5) Cholesterol (Note 12): 0.6 (6) Phytosterol 0.1 (7) Remaining amount of purified water (8) Niacinamide 3.0 (9) Tranexamic acid 2.0 (10) (acrylic acid / C10-30 alkyl acrylate) copolymer (Note 13) 0.4 (11) Triethanolamine 0.4 (12) Dimethicone diethyl benzalmalonate 1.2 (13) 4-tert-Butyl-4´-methoxy-dibenzoylmethane 2.0 (14) 2-Ethylhexyl p-methoxycinnamate 7.0 (15) Diethylamino hydroxybenzoyl hexyl benzoate 2.5 (16) Stearic acid hydrogenated castor oil (Note 14) 1.0 (17) Propylene glycol dicaprylate 5.0 (18) Ethyl oleate 0.3 (19) Natural Vitamin E 0.1 (20) Rosemary oil 0.01 (21) 1,2-Pentanediol 0.1 (22) Zinc oxide 2.0 (23) Water-soluble collagen 0.01 (24) Chamomile flower extract 0.05 (25) Calendula officinalis flower extract 0.05 (26) Glycerin 1.0 (27) Ethanol 7.0 (28)Fragrance 0.1 (Note 11) Nikkor Resinol S-10 (manufactured by Nikko Chemicals) (Note 12) Kairei Marine Cholesterol (manufactured by Nippon Suisan Kaisha) (Note 13) Pemulen TR-2 (manufactured by NOVEON) (Note 14) Castride MS (National Mimatsu)

[0048] (Manufacturing method) A: Components (1) to (6) are homogeneously dissolved and mixed at 75°C. B: Components (7) to (11) are uniformly dissolved and mixed at 70°C. C: Components (12) to (19) are homogeneously dissolved and mixed at 80°C. D: Add B and C to A and emulsify at 70°C. E: Components (20) to (28) were added to and mixed with D, and then cooled to 40° C. to obtain a sunscreen (oil-in-water type). The sunscreen (oil-in-water type) obtained in this manner was excellent in the aggregation suppression effect, penetration feeling, non-stickiness, and firmness of the skin after application.

[0049] Example 16: Oil-in-water emulsion (Component) (%) (1) 1,3-butylene glycol 5.0 (2) Dipropylene glycol 5.0 (3) Alkyltrimethylammonium chloride (Note 2) 0.03 (4) Hydrogenated soybean phospholipid (Note 7) 0.2 (5) Cholesterol (Note 12): 0.7 (6) Remaining purified water (7) Niacinamide 8.0 (8) 0.2% sodium hydroxide solution (9) N-Myristoyl-L-glutamic acid 0.2 (10) Polyoxyethylene (10) Hydrogenated castor oil 0.2 (11) Phytosteryl Macadamiate (Note 15) 1.0 (12) Caprylic / caprylic triglyceride 0.2 (13) Tocopherol nicotinate 0.01 (14) Natural Vitamin E 0.1 (15) Rice germ oil 0.01 (16) Tocopherol acetate 0.01 (17) Polyoxyethylene sorbitan monooleate (20E.O.) 1.5 (18) Stearyl alcohol 0.5 (19) Behenyl alcohol 1.0 (20) 1,2-Pentanediol 0.1 (21) Stearyl alcohol 0.5 (22) Carboxyvinyl polymer 0.2 (23) (Sodium acrylate / sodium acryloyldimethyltaurate) Copolymer (Note 16) 0.5 (24) Tranexamic acid 1.0 (25) Diglycerin 0.5 (26) Enmeisou Extract 0.05 (27) Jania Rubens Extract 0.05 (28) Black soybean extract 0.05 (29) Sesame germination extract 0.05 (30) Glycerin 1.0 (31) Ethanol 5.0 (32)Fragrance 0.1 (Note 15) PLANDOOL-MAS (manufactured by Nippon Fine Chemicals) (Note 16) SIMULGEL EG QD (SEPPIC)

[0050] (Manufacturing method) A: Components (1) to (5) are homogeneously dissolved and mixed at 75°C. B: While maintaining A at 75°C, a portion of component (6) is added and stirred with a dispers mixer to obtain a vesicle dispersion. C: The remaining ingredients (6) to (8) are uniformly dissolved and mixed at room temperature. D: Components (9) to (19) are homogeneously dissolved and mixed at 80°C. E: While maintaining D at 75°C, add the heated C and emulsify. F: Components (20) to (32) were added to and mixed with E, and then cooled to 40° C. to obtain an oil-in-water emulsion. The oil-in-water emulsion obtained in this manner was excellent in the aggregation suppression effect, penetration feeling, non-stickiness, and firmness of the skin after application.

Claims

1. The following components (A) to (D): (A) Niacinamide 1-10% (B) Cationic surfactant (C) Anionic polymer (D) Water A skin topical preparation comprising The component (B) is at least one selected from the group consisting of alkyltrimethylammonium chloride and di-long-chain acylalkylhydroxyalkylammonium salts, The content mass ratio of the component (A) to the component (B) (component (A) / component (B)) is 10 to 500, The above-mentioned external skin preparation, wherein the content mass ratio of component (A) to component (C) (component (A) / component (C)) is 5.0 to 150.

2. 2. The external skin preparation according to claim 1, further comprising a component (E) a nonionic surfactant having an HLB of 10 to 18.

3. 3. The skin topical preparation according to claim 1, wherein the component (B) is dicocoyl ethyl hydroxyethylmonium methosulfate and / or behentrimonium chloride.

4. The external skin preparation according to any one of claims 1 to 3, wherein the component (C) contains one or more selected from the group consisting of carboxyvinyl polymers and / or alkyl-modified carboxyvinyl polymers.

5. 5. The skin external preparation according to claim 1, wherein the component (B) forms vesicle particles.

6. A method for inhibiting aggregation of a cationic surfactant and an anionic polymer, comprising adding niacinamide to a skin topical preparation containing a cationic surfactant, an anionic polymer and water in an amount such that the content of niacinamide in the skin topical composition is 1-10% by mass, the mass ratio of the niacinamide to the cationic surfactant is 10-500, and the mass ratio of the niacinamide to the anionic polymer is 5.0-150.

7. A method for improving the stability of an external skin preparation comprising a cationic surfactant, an anionic polymer and water, comprising adding niacinamide in an amount such that the content in the external skin composition is 1-10% by mass, the mass ratio of niacinamide to the cationic surfactant is 10-500, and the mass ratio of niacinamide to the anionic polymer is 5.0-150.

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