Kit and beauty method using microneedle sheet

Abstract

To provide a kit that allows a user to easily store an applicator for microneedles without breaking the microneedles, and a cosmetic process that uses the kit.SOLUTION: The kit comprises: at least one microneedle sheet 1 comprising a substrate layer 1-2 and a plurality of microneedles 1-1 on the substrate layer 1-2, the microneedles 1-1 comprising at least one water-soluble or water-dispersible polymer; and at least one applicator comprising at least one application surface; the substrate layer 1-2 of the microneedle 1-1 sheet being capable of being attached to the application surface of the applicator. The kit allows a user to easily store the applicator for the microneedles 1-1 without breaking the microneedles.SELECTED DRAWING: Figure 1

Description

[Technical field]

[0001] The present invention relates to a kit including at least one microneedle sheet having a plurality of microneedles, and a cosmetic method for keratinous materials such as the skin and lips using the microneedle sheet. [Background technology]

[0002] The stratum corneum (SC) constitutes the main barrier for exogenous substances, including low molecular weight materials. In general, exogenous substances that penetrate the skin must diffuse through the highly organized intercellular lipid bilayer of the stratum corneum. This intercellular micropathway, which is lipophilic, is the main route by which exogenous substances pass the SC barrier by passive diffusion along the concentration gradient between the delivery vehicle and the SC. Some exogenous substances have difficulty penetrating into the skin.

[0003] In order to deliver exogenous substances deeper into the skin, injections using conventional needles can be performed. However, such injections cause pain and must be performed by a professional such as a doctor. Therefore, injections using conventional needles are not common for cosmetic purposes.

[0004] The idea of ​​using a microstructured device with multiple microneedles to break the stratum corneum (SC) barrier was first proposed in the 1970s.The manufacture of microneedle arrays has been described in the art, for example in WO2008 / 139786, WO2009 / 040548, WO2015 / 147040 and WO2016 / 076442.Microneedles have the advantage that they can potentially penetrate the SC and be self-administered without the pain caused by the use of conventional needles for injection.

[0005] Generally, the microneedles are aligned on a substrate layer to form a microneedle sheet, which is applied onto a keratinous material, such as skin, for some time so that the microneedles can be inserted into the keratinous material and dissolved or disintegrated within the keratinous material by moisture or water inside the keratinous material.

[0006] There are several conventional devices for applying microneedles onto the skin. One such device is an applicator having a roller on which the microneedles are formed.

[0007] However, because the microneedles are formed on a roller, storing the applicator without breaking the microneedles is conventionally difficult with such devices. [Prior art documents] [Patent documents]

[0008] [Patent Document 1] WO2008 / 139786 [Patent Document 2] WO2009 / 040548 [Patent Document 3] WO2015 / 147040 [Patent Document 4] WO2016 / 076442 [Patent Document 5] U.S. Patent No. 6,219,574 [Patent Document 6] Canadian Patent Application No. 2226718 [Patent Document 7] U.S. Patent No. 6,652,478 [Patent Document 8] U.S. Patent No. 2,528,378 [Patent Document 9] U.S. Patent No. 2,781,354 [Patent Document 10] U.S. Patent No. 4,874,554 [Patent Document 11] U.S. Patent No. 4,137,180 [Non-patent literature]

[0009] [Non-Patent Document 1] Walter Noll, Chemistry and Technology of Silicones (1968), Academic Press [Non-Patent Document 2] Cosmetics and Toiletries, Vol. 91, January 1976, pp. 27-32, Todd & Byers, Volatile Silicone Fluids for Cosmetics [Non-Patent Document 3] ASTM Standard 445 Appendix C [Non-Patent Document 4] CTFA Dictionary, 9th ed., 2002 [Non-Patent Document 5] CTFA Dictionary, 3rd ed., 1982 [Non-Patent Document 6] CTFA Dictionary, 5th ed., 1993 [Non-Patent Document 7] CTFA 1997 [Non-Patent Document 8] MRPorter, "Handbook of Surfactants", Blackie & Son publishers (Glasgow and London), 1991, pp. 116-178. [Non-Patent Document 9] "The HLB system. A time-saving guide to emulsifier selection" (ICI Americas Inc., 1984) Summary of the Invention [Problem to be solved by the invention]

[0010] An object of the present invention is to provide a kit that allows a user to easily store an applicator for a microneedle without breaking the microneedle, as well as a cosmetic method in which the kit can be used. [Means for solving the problem]

[0011] The above objectives are: At least one microneedle sheet comprising a base layer and a plurality of microneedles on the base layer, the microneedles comprising at least one water-soluble or water-dispersible polymer; at least one applicator having at least one application surface; A kit comprising: The base layer of the microneedle sheet is attachable to the application surface of the applicator. This can be achieved by means of a kit.

[0012] It is preferable that after the substrate layer of the microneedle sheet is attached to the application surface of the applicator, it is removable from the application surface of the applicator.

[0013] The microneedle sheet may comprise at least one base layer which may be fixed onto the base layer.

[0014] The microneedle sheet may comprise at least one adhesive layer which may be fixed onto the base layer or base layer (if present).

[0015] The microneedle sheet may comprise at least one release layer which may be placed on the adhesive layer.

[0016] The microneedles may have a height of 50 to 1000 microns, preferably 100 to 750 microns, more preferably 150 to 500 microns.

[0017] The application surface of the applicator may be curved. The applicator may comprise at least one cylindrical roller having a curved side, and the curved side of the cylindrical roller may comprise the application surface.

[0018] The application surface of the applicator may be a planar surface.The applicator may comprise at least one stamp having at least one planar surface, the planar surface of the stamp may comprise the application surface.

[0019] The kit according to the present invention may further comprise at least one container in which the microneedle sheet can be stored.

[0020] The container may comprise at least one soft and / or porous article, preferably selected from a sponge, a woven or non-woven fabric, and combinations thereof.

[0021] The kit according to the present invention may further comprise at least one cosmetic composition.

[0022] The present invention also relates to a cosmetic method for keratinous materials such as the skin or lips, comprising the steps of: attaching at least one microneedle sheet to at least one application surface of at least one applicator; the microneedle sheet comprising a base layer and a plurality of microneedles on the base layer, the microneedles comprising at least one water-soluble or water-dispersible polymer, attaching the base layer to the application surface of the applicator; applying the applicator onto the keratinous material such that the microneedles contact the keratinous material; The present invention relates to a cosmetic method comprising the steps of: [Brief description of the drawings]

[0023] [Figure 1] FIG. 2 is a cross-sectional view of an example of a microneedle sheet used for the present invention. [Diagram 2]FIG. 1 is a perspective view of an example applicator having at least one cylindrical roller having a curved side with an application surface. [Diagram 3] A perspective view of an example applicator with a substrate layer of a microneedle sheet attached thereto. [Figure 4] A perspective view of how to use an applicator with a microneedle sheet. [Diagram 5] FIG. 2 is a front view of an example applicator having at least one stamp with at least one planar surface with an application surface. [Figure 6] 1 is a cross-sectional view of an example of a container that can be used for the present invention. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0024] After careful consideration, the inventors discovered that it is possible to provide a kit that can enable a user to easily store an applicator for a microneedle without breaking the microneedle.

[0025] Therefore, one aspect of the present invention is At least one microneedle sheet comprising a base layer and a plurality of microneedles on the base layer, the microneedles comprising at least one water-soluble or water-dispersible polymer; at least one applicator having at least one application surface; A kit comprising: The base layer of the microneedle sheet is attachable to the application surface of the applicator. It's a kit.

[0026] According to the present invention, the microneedle sheet is separated from the applicator when not in use. The microneedle sheet can be attached to the applicator when in use. Thus, the user can easily store the applicator without breaking the microneedles.

[0027] It is preferable that the substrate layer of the microneedle sheet is removable from the application surface of the applicator after being attached to the application surface of the applicator. In this case, the applicator can be used repeatedly by replacing the microneedle sheet on the applicator. The replacement of the microneedle sheet can be performed by the user.

[0028] When the kit according to the present invention further includes at least one container capable of storing the microneedle sheet, it may be easier to store the microneedle sheet without breaking the microneedles.

[0029] The present invention can provide a pain-free cosmetic treatment since the microneedles do not cause any pain, so the kit according to the present invention is advantageous for cosmetic or non-therapeutic treatments.

[0030] The kit and cosmetic method according to the present invention are described in detail herein below.

[0031] [kit] The kit according to the present invention comprises: At least one microneedle sheet comprising a base layer and a plurality of microneedles on the base layer, the microneedles comprising at least one water-soluble or water-dispersible polymer; at least one applicator having at least one application surface; Including, The substrate layer of the microneedle sheet can be attached to the application surface of the applicator.

[0032] {Microneedle sheet} The microneedle sheet used for the kit according to the present invention comprises a base layer and a plurality of microneedles comprising at least one water-soluble or water-dispersible polymer on the base layer.

[0033] The microneedle sheet used for the present invention may be a cosmetic device, preferably a cosmetic device for keratinous materials, more preferably a cosmetic device for the skin, in particular for the facial skin, as well as for the lips.

[0034] (Microneedle) The microneedle sheet used for the present invention comprises a plurality of microneedles.

[0035] The microneedles are present on the surface of the base layer. The microneedles may be present on 50% or more, preferably 70% or more, more preferably 90% or more of the surface of the base layer.

[0036] Preferably, the microneedles are present on one of the surfaces of the backing layer.

[0037] The microneedles of the microneedle sheet used for the present invention are preferably designed to penetrate or enter into the stratum corneum of the skin, in particular of the skin of the face, as well as of the lips.

[0038] The microneedles may be of any size and shape suitable for piercing the stratum corneum. It may be preferable for the microneedles to be designed to traverse through the stratum corneum. The microneedles may be capable of creating openings in the stratum corneum.

[0039] If necessary, the height of the microneedles may be altered to allow penetration into the epidermis and / or dermis of the skin, preferably into the upper dermis, and more preferably into the lower dermis.

[0040] The shape of the microneedle is not limited as long as it is a "needle". It will be clear to those skilled in the art that the microneedle for the present invention can have any reasonable shape, including but not limited to cone-shaped, rod-shaped and / or column-shaped. As such, the microneedle may have the same diameter at the tip as at the base, or the diameter may taper from the base to the tip.

[0041] For example, the shape of the microneedle may be in the form of a triangular pyramid, a square pyramid or a pentagonal pyramid. Alternatively, the microneedle may be in the form of a cylinder, preferably with a tip, formed by cutting a cylinder diagonally.

[0042] The cross-section of the microneedles may take any geometric form including circular, triangular, square, rectangular, polygonal, regular or irregular shapes, etc. In one embodiment, the group of microneedles may take the form of hollow microcapillaries.

[0043] Thus, reference is made to the type of microprojection or microprotrusion utilized as a "microneedle." In many cases, those skilled in the art will understand that the same inventive principles apply to the use of other microprojections or microprotrusions to penetrate the skin. Other microprojections or microprotrusions include, for example, microblades, as described in U.S. Pat. No. 6,219,574 and Canadian Patent Application No. 2,226,718, and edged microneedles, as described in U.S. Pat. No. 6,652,478.

[0044] The height or length of the microneedles of the microneedle sheet used for the present invention may be 50 to 1000 microns, preferably 100 to 750 microns, and more preferably 150 to 500 microns.

[0045] According to one embodiment of the invention, the microneedle is in the form of a cone.

[0046] The cone may have a distal end, such as a tip and a base. The base may be circular or elliptical in shape.

[0047] The height or length of the cones of the microneedles of the microneedle sheet used for the present invention may be 50 to 1000 microns, preferably 100 to 750 microns, more preferably 150 to 500 microns.

[0048] The conical bases of the microneedles of the microneedle sheet used for the present invention may have a diameter or width of 50 to 350 microns, preferably 100 to 300 microns, and more preferably 150 to 250 microns. When the conical bases of the microneedles of the microneedle sheet used for the present invention are elliptical or oval in shape, the length or width of the main axis of the ellipse may be 50 to 350 microns, preferably 100 to 300 microns, and more preferably 150 to 250 microns.

[0049] The microneedles may have an aspect ratio (length / width at base) of at least about 3: 1, at least about 2: 1, or at least about 1: 1. The ratio of the microneedle's (height of the cone) / (diameter at the base of the cone) may be 1 or greater, preferably 1.5 or greater, more preferably 2.0 or greater.

[0050] Preferably, the microneedle has a resistance of 50.0 N / cm 2 Less than, for example, 20.0N / cm 2 Less than, for example, 10N / cm 2 When an insertion pressure of less than 100 μm is applied along the length of the microneedle, it does not fracture under that force.

[0051] It is also preferred that the microneedle sheet used for the present invention, in particular the microneedles of the microneedle sheet, have a Young's modulus of 50 N / mm or more, preferably 55 N / mm or more, more preferably 60 N / mm or more.

[0052] It may be preferred that the microneedles are capable of penetrating into keratinous materials such as the skin or lips to a depth of 200 microns or less, preferably 180 microns or less, more preferably 160 microns or less.

[0053] The microneedles may be soluble or non-soluble. It is preferred that the microneedles are soluble.

[0054] By "dissolvable microneedles" it is meant that the microneedles can be destroyed or disintegrated within keratinous materials such as the skin or lips, for example by natural moisturizing agents or external moisture.

[0055] The microneedles of the microneedle sheet used for the present invention may comprise at least one water-soluble or water-dispersible polymer.As used herein, the terms "water-soluble" and "water-dispersible" mean that they are soluble and dispersible, respectively, when in contact with water.A single water-soluble or water-dispersible polymer may be used.Two or more water-soluble or water-dispersible polymers may be used in combination.

[0056] It is preferred that the water-soluble or water-dispersible polymer is soluble or dispersible in skin or lips.Therefore, in one embodiment of the present invention, the water-soluble or water-dispersible polymer can be dissolved or dispersed after insertion into keratinous material such as skin or lips.Due to the solubility or dispersibility of the polymer, the microneedles of the microneedle sheet used for the present invention can effectively release the agent (if present) in the microneedle.Optional external water combined with the application of the microneedle sheet can be used to promote the dissolution or dispersion of the microneedle.

[0057] It is preferred that the water-soluble or water-dispersible polymer is soluble or dispersible in the surface layer of a keratinous material such as the skin or lips.

[0058] The water-soluble or water-dispersible polymer may be selected from hyaluronic acid (particularly low molecular weight hyaluronic acid), monosaccharides, disaccharides, oligosaccharides, polysaccharides (including derivatives thereof, such as hydroxymethylcellulose), dextrins, dextran, polyethylene glycol, polyvinyl alcohol, poly(methyl vinyl ether / maleic anhydride), polyvinylpyrrolidone, poly(methyl / vinyl ether / maleic acid) (PMVE / MA) and esters thereof, poly(methyl / vinyl ether / maleic anhydride) (PMVE / MAH), and mixtures thereof.

[0059] The water-soluble or water-dispersible polymer may have a molecular weight of from 10,000 to 200,000 daltons, preferably from 30,000 to 150,000 daltons, and more preferably from 50,000 to 100,000 daltons.

[0060] The low molecular weight hyaluronic acid may have a molecular weight of 100 kDa or less, preferably 70 kDa or less, and more preferably 50 kDa or less.

[0061] The polyvinylpyrrolidone may have a molecular weight between 1 kDa and 300 kDa, preferably between 5 kDa and 200 kDa, more preferably between 7 kDa and 100 kDa.

[0062] Poly(methyl / vinyl ether / maleic acid) (PMVE / MA) and its esters, as well as poly(methyl / vinyl ether / maleic anhydride) (PMVE / MAH), are known as Gantrez-type polymers.

[0063] The amount (solid basis) of the water-soluble or water-dispersible polymer in the microneedles of the microneedle sheet used for the present invention may be 50% by mass or more, preferably 60% by mass or more, more preferably 70% by mass or more, based on the total mass of the microneedles. The amount (solid basis) of the water-soluble or water-dispersible polymer in the microneedles of the microneedle sheet used for the present invention may be 100% by mass or less, preferably 90% by mass or less, more preferably 80% by mass or less, based on the total mass of the microneedles. Thus, the amount (solid basis) of the water-soluble or water-dispersible polymer in the microneedles of the microneedle sheet used for the present invention may be 50% by mass to 100% by mass, preferably 60% by mass to 90% by mass, more preferably 70% by mass to 80% by mass, based on the total mass of the microneedles.

[0064] It may be possible that the microneedles of the microneedle sheet used for the present invention comprise at least one material that is swellable, more preferably water-swellable, even more preferably swellable in keratinous materials such as skin or lips. The material may be a polymer that is swellable, more preferably water-swellable, even more preferably swellable in keratinous materials. As used herein, the term "water-swellable" means that it is swellable when in contact with water. The swellable material or polymer may have a high swelling capacity, such that it can swell at least 10 times more in 1 hour of incubation in a saline solution or phosphate buffered saline, preferably at least 20 times in 1 hour of incubation, more preferably at least 30 times in 1 hour of incubation, even more preferably at least 40 times in 1 hour of incubation, and most preferably about 45 to 55 times in 1 hour of incubation in vitro.

[0065] It may be preferred that at least the distal end portion of the microneedle swells at least twice as large upon insertion into the keratinous material, more preferably within less than 1 hour after insertion into the keratinous material, and even more preferably within 24 hours.

[0066] The swellable material, preferably the swellable polymer, may have high viscoelasticity so that it can form a gel after in vitro incubation in saline solution or phosphate buffered saline. The gel has a high elastic modulus G', a high viscous modulus G'', a tangent (δ) of less than 1 (tangent (δ) = G'' / G') and a high consistency G* (G*) even at low frequencies (0.01 Hz) in a dynamic frequency sweep test using a rheometer. 2 =G' 2 +G'' 2 ) is observed.

[0067] In one embodiment, the swellable material, preferably a swellable polymer, is not water soluble or water dispersible.

[0068] In another embodiment, the swellable material, preferably a swellable polymer, may be a hydrogel-forming polymer.

[0069] The swellable polymer may be selected from high molecular weight hyaluronic acid, crosslinked hyaluronic acid, crosslinked polyethylene glycol, polyethylene glycol crosslinked polylactic acid or polyglycolic acid or poly-lactic acid-co-glycolic acid or polydioxanone, poly(styrene)-block-poly(acrylic acid), polyethylene glycol crosslinked PMVE / MA, crosslinked polyvinylpyrrolidone, sodium starch glycolate, cellulose, natural and synthetic rubbers; alginates; sodium polyacrylate, PEG crosslinked poly(methyl / vinyl ether / maleic acid) (PMVE / MA) and esters thereof, PEG crosslinked poly(methyl / vinyl ether / maleic anhydride) (PMVE / MAH) and esters thereof, and mixtures thereof.

[0070] High molecular weight hyaluronic acid may have a molecular weight of more than 500 kDa, preferably more than 1000 kDa, more preferably more than 2100 kDa, preferably less than 10000 kDa.

[0071] Unless otherwise defined, molecular weight herein refers to number average molecular weight.

[0072] Poly(methyl / vinyl ether / maleic acid) (PMVE / MA) and its esters, as well as poly(methyl / vinyl ether / maleic anhydride) (PMVE / MAH), are known as Gantrez-type polymers.

[0073] The amount of swelling material (solid basis) in the microneedles of the microneedle sheet used for the present invention may be 1% by mass or more, preferably 5% by mass or more, more preferably 10% by mass or more, based on the total mass of the microneedles. The amount of swelling material (solid basis) in the microneedles of the microneedle sheet used for the present invention may be 30% by mass or less, preferably 25% by mass or less, more preferably 20% by mass or less, based on the total mass of the microneedles. Thus, the amount of swelling material (solid basis) in the microneedles of the microneedle sheet used for the present invention may be 1% by mass to 30% by mass, preferably 5% by mass to 25% by mass, more preferably 10% by mass to 20% by mass, based on the total mass of the microneedles.

[0074] When the microneedles of the microneedle sheet used for the present invention comprise at least one swellable material, preferably at least one swellable polymer, the microneedles may be swellable, such that they can improve the aesthetic appearance of keratinous materials, preferably of skin, more preferably of facial skin, by reducing the appearance of wrinkles.

[0075] In other words, if the microneedle is swellable, it can swell in the skin, for example with the absorption of water in the skin, further increasing the volume of the microneedle. Such volume expansion under the skin surface at the wrinkle site can effectively push the wrinkle from inside the skin, making the wrinkle shallower and wider. In this way, the wrinkle can be reduced or made less noticeable.

[0076] The tip separation distance between each of the individual microneedles on the backing layer can be modified to have a separation distance short enough to ensure penetration of the skin or lips by the microneedles while at the same time providing a high transdermal transport rate.

[0077] In one embodiment, the range of tip separation distance between the microneedles may be in the range of 10-1000 μm, for example 30-800 μm or 50-600 μm. This may allow a compromise to be achieved between effective penetration of the stratum corneum by as many microneedles as possible and the room needed for possible swelling of the microneedles (if they are swellable).

[0078] In one embodiment, the density of the microneedles is between 100 and 2000 microneedles / cm 2 , preferably 200 to 1000 microneedles / cm 2 , and even more preferably 200 to 500 microneedles / cm 2 may be also possible.

[0079] (Polyol) According to one embodiment, at least one of the microneedles of the microneedle sheet may comprise at least one polyol. A single type of polyol may be used. Two or more types of polyols may be used in combination.

[0080] The polyol is heated at atmospheric pressure (760 mmHg or 10 5 It is preferable that the composition is in the form of a liquid at room temperature, such as 25° C., under 1000 Pa.

[0081] The term "polyol" as used herein means an alcohol having two or more hydroxyl groups, and does not include sugars or their derivatives. Derivatives of sugars include sugar alcohols obtained by reducing one or more carbonyl groups of sugars, as well as sugars or sugar alcohols in which one or more hydrogen atoms in one or more of their hydroxyl groups have been replaced with at least one substituent, such as an alkyl group, a hydroxyalkyl group, an alkoxy group, an acyl group, or a carbonyl group.

[0082] The polyol used in the present invention is heated at atmospheric pressure (760 mmHg or 10 5 It is a liquid at room temperature, such as 25° C., under 1000 MPa (2.2 Pa).

[0083] The polyol is a C2-C hydroxyl group containing at least two hydroxyl groups, preferably 2 to 5 hydroxyl groups. 24 It may be a polyol, preferably a C2 to C9 polyol.

[0084] The polyol may be a natural or synthetic polyol. The polyol may have a linear, branched or cyclic molecular structure.

[0085] The polyol can be selected from glycerin and its derivatives, and glycols and its derivatives. The polyol can be selected from glycerin, diglycerin, polyglycerin, ethylene glycol, diethylene glycol, propylene glycol, dipropylene glycol, butylene glycol, pentylene glycol, hexylene glycol, C6-C 24 It may be selected from the group consisting of polyethylene glycol, 1,3-propanediol, 1,4-butanediol and 1,5-pentanediol.

[0086] When the microneedles of the microneedle sheet comprise a polyol, the brittleness of the microneedles can be reduced or adjusted.

[0087] (Sugars) According to one embodiment, at least one of the microneedles of the microneedle sheet may comprise at least one type of sugar or its derivative. A single type of sugar or its derivative may be used. Two or more types of sugars, their derivatives, or a combination of sugars and their derivatives may be used.

[0088] The term "saccharide" as used herein means a polyalcohol consisting of one or more glucosidic units and which may have at least one carbonyl group. Derivatives of saccharides include sugar alcohols obtained by reducing one or more carbonyl groups of saccharides, as well as saccharides or sugar alcohols in which one or more hydrogen atoms in one or more of their hydroxyl groups have been replaced with at least one substituent, such as an alkyl group, a hydroxyalkyl group, an alkoxy group, an acyl group or a carbonyl group.

[0089] The saccharides may be selected from the group consisting of monosaccharides, oligosaccharides, polysaccharides, and mixtures thereof.

[0090] The monosaccharide may be selected from the group consisting of glucose, fructose, galactose, mannose, talose, sorbose, xylose, lyxose, fucose, arabinose, rhamnose, ribose, ribulose, xylulose, sorbitol, triose, pentose, hexose, ketose, glucosamine, and mixtures thereof.

[0091] The oligosaccharides may be selected from the group consisting of maltose, lactose, sucrose, cellobiose, trehalose, sucrose, fructo-oligosaccharides, dextrins, and mixtures thereof. Preferred oligosaccharides may consist of 2 to 10 monosaccharides.

[0092] The polysaccharide may be selected from alginic acid, guar gum, xanthan gum, gum arabic, arabinogalactan, carrageenan, agar, karaya gum, tragacanth gum, tara gum, pectin, locust bean gum, curdlan, gellan gum, dextran, pullulan, hyaluronic acid, cellulose and its derivatives, and mixtures thereof.

[0093] The saccharide derivative may be selected from the group consisting of erythritol, lactitol, maltitol, mannitol, sorbitol and xylitol, in which at least one hydrogen in the hydroxyl group may be replaced with at least one substituent such as an alkyl group, a hydroxyalkyl group, an alkoxy group, an acyl group or a carbonyl group.

[0094] The above sugars can exist in the form of L- or D-isomers.

[0095] (beauty active ingredient) According to one embodiment, at least one of the microneedles of the microneedle sheet used for the present invention may contain at least one cosmetically active ingredient. A single cosmetically active ingredient may be used. Two or more cosmetically active ingredients may be used in combination.

[0096] The type of cosmetic active is not limited. The cosmetic active may be selected from the group consisting of whitening agents, antioxidants, cleansing agents, anti-aging agents, skin texture treatment agents, and combinations thereof.

[0097] For example, anti-aging agents can be used as cosmetic active ingredients.

[0098] Examples of anti-aging agents include antioxidants, moisturizers, free radical scavengers, keratolytic agents such as alpha- or beta-hydroxy acids, vitamins such as vitamin C and its derivatives and vitamin E and its derivatives, anti-elastase and anti-collagenase agents, protides, fatty acid derivatives, steroids, trace elements, bleaching agents, vegetable oils such as almond oil, extracts of algae and plankton, enzymes and coenzymes, flavonoids and ceramides, and mixtures thereof.

[0099] The amount of cosmetically active ingredient in the microneedles of the microneedle sheet used in the present invention is not limited, and may be 0.01% by mass to 10% by mass, preferably 0.05% by mass to 5% by mass, and more preferably 0.1% by mass to 1% by mass, relative to the total mass of the microneedles.

[0100] It is also possible that the amount of cosmetically active ingredient in the microneedles of the microneedle sheet used for the present invention is less than 0.01% by weight, based on the total weight of the microneedles. In one embodiment, the microneedles of the microneedle sheet according to the present invention may not contain any cosmetically active ingredient.

[0101] (base material layer) The microneedle sheet used for the present invention comprises a substrate layer on which the microneedles reside or are mounted.

[0102] The substrate layer of the microneedle sheet used for the present invention may be either soluble or non-soluble.

[0103] It is preferable that the substrate layer of the microneedle sheet used for the present invention is soluble in water or disintegrable in water.

[0104] The substrate layer of the microneedle sheet used for the present invention may contain at least one water-soluble or water-dispersible polymer as described above. In other words, the above description of the water-soluble or water-dispersible polymer that may be contained in the microneedles of the microneedle sheet applies to the water-soluble or water-dispersible polymer that may be contained in the substrate layer.

[0105] For example, the amount of water-soluble or water-dispersible polymer (solid basis) in the substrate layer of the microneedle sheet used for the present invention may be 50% by mass or more, preferably 60% by mass or more, more preferably 70% by mass or more, based on the total mass of the substrate layer. The amount of water-soluble or water-dispersible polymer (solid basis) in the substrate layer of the microneedle sheet used for the present invention may be 100% by mass or less, preferably 90% by mass or less, more preferably 80% by mass or less, based on the total mass of the substrate layer. Therefore, the amount of water-soluble or water-dispersible polymer (solid basis) in the substrate layer of the microneedle sheet used for the present invention may be 50% by mass to 100% by mass, preferably 60% by mass to 90% by mass, more preferably 70% by mass to 80% by mass, based on the total mass of the substrate layer.

[0106] The backing layer and the microneedles may or may not be integral.

[0107] When the substrate layer and the microneedles are integrated, the substrate layer and the microneedles may comprise at least one common water-soluble or water-dispersible polymer.

[0108] Thus, in one embodiment, the substrate layer and the microneedles can be a single component that includes at least one common water-soluble or water-dispersible polymer, and preferably, the single component can be prepared using the same water-soluble or water-dispersible polymer.

[0109] On the other hand, if the substrate and microneedles are not integrated, i.e. the substrate layer is different or separate from the microneedles, the substrate layer and the microneedles may be made from different materials.

[0110] Thus, in another embodiment, the backing layer and the microneedles may be an assembly of two different or separate components.

[0111] In the latter embodiment, the substrate layer may be made, for example, from a fiber or a polymer film.

[0112] The fibers can be made from natural fibers such as cotton, semi-natural materials such as viscose, synthetic fibers such as polyester and polypropylene fibers, and combinations thereof. The porous substrate can be selected from woven or non-woven fabrics.

[0113] The polymeric film can be made from synthetic resins such as polyurethane, polystyrene, polycarbonate, polyethylene terephthalate, poly(ethylene-co-vinyl alcohol), polyethylene, polyester, polyamide, and combinations thereof.

[0114] The substrate sheet can be cut into the form of a patch, disc, mask, towel, glove, pre-cut roll, or any other suitable form for cosmetic use.

[0115] (additional layer) The microneedle sheet used for the present invention may comprise at least one additional layer.

[0116] In one embodiment, the microneedle sheet comprises at least one base layer as an additional layer, and the base layer is fixed on the base layer.For fixing, any means can be used to firmly attach the base layer on the base layer.For example, any adhesive can be used to fix the base layer on the base layer.

[0117] The shape and material of the base layer are not limited.

[0118] The substrate may be a porous or a non-porous substrate.

[0119] The porous substrate may be composed of fibers. The fibers may be made of natural fibers such as cotton, semi-natural materials such as viscose, synthetic fibers such as polyester and polypropylene fibers, and combinations thereof. The porous substrate may be selected from woven or non-woven fabrics.

[0120] The non-porous base layer may be composed of a polymer film, which may be made from synthetic resins such as polyurethane, polystyrene, polycarbonate, polyethylene terephthalate, poly(ethylene-co-vinyl alcohol), polyethylene, polyester, polyamide, and combinations thereof.

[0121] If the microneedles of the microneedle sheet and the substrate layer are different or separate components, the substrate layer may function as the base layer, and thus in this case a base layer may not be required.

[0122] In one embodiment, the microneedle sheet comprises at least one adhesive layer as an additional layer, which is fixed onto the base layer or base layer (if present).

[0123] The material of the adhesive layer is not limited. It is preferable to use an adhesive layer that can be removed from the application surface of the applicator. For example, it is preferable to use an adhesive layer that can be peeled or removed from the application surface of the applicator.

[0124] It may be preferable to use a pressure-sensitive adhesive to form the adhesive layer. As the pressure-sensitive adhesive, any conventional pressure-sensitive adhesive may be used. The pressure-sensitive adhesive may comprise at least one adhesive polymer. The adhesive polymer may be selected from the group consisting of (meth)acrylate polymers, vinyl acetate-acrylate copolymers, copolymers containing polyisobutylene, polystyrene or polybutadiene, rosin-based resins, polyterpene resins, petroleum-based resins, terpene phenolic resins, silicone resins, natural or synthetic rubbers, and mixtures thereof.

[0125] In one embodiment, the microneedle sheet comprises at least one additional layer, a release layer, which is disposed on the adhesive layer.

[0126] The release layer can protect the adhesive layer.

[0127] The material of the release layer is not limited. It is preferable to use a thin film or sheet, such as paper, which is coated with at least one release agent. Any conventional release agent can be used as the release agent. It is preferable that the release layer can be easily peeled off from the adhesive layer.

[0128] It is preferable to form at least one tab for the release layer so that a user can easily grasp the tab and peel the release layer from the adhesive layer. The tab can be formed, for example, by slightly bending a tip or edge of the release layer.

[0129] An example of a microneedle sheet that can be used for the present invention is illustrated in FIG.

[0130] Figure 1 shows an example of a multilayer microneedle sheet 1. The multilayer microneedle sheet 1 comprises microneedles 1-1, a substrate layer 1-2, a base layer 1-3, an adhesive layer 1-4 and a release layer 1-5. These layers are laminated in the order shown in Figure 1.

[0131] In this example, the substrate layer 1-2 is different from the base layer 1-3. However, if the material of the substrate layer 1-2 is the same as the material of the base layer 1-3, it is possible not to use the base layer 1-3. In this case, the adhesive layer 1-4 may be formed on the substrate layer 1-3.

[0132] In this example, the release layer 1-5 has a tab 1-5-1. A user can grab the tab 1-5-1 to peel the release layer 1-5 from the adhesive layer 1-4. Therefore, when the multilayer microneedle sheet 1 is used, a user can easily peel the release layer 1-5 from the adhesive layer 1-4.

[0133] (preparation) There is no limitation on how to prepare the microneedle sheet used for the present invention. The microneedle sheet used for the present invention can be prepared based on conventional techniques such as molding, 3D printing, and air blowing to hold droplets.

[0134] The microneedle sheet used for the present invention can be prepared, for example, by a method including a step of molding a composition containing at least one water-soluble or water-dispersible polymer described above.

[0135] In one embodiment, the microneedle sheet used for the present invention is (a) providing a mold having a cavity corresponding to the negative of a microneedle; (b) filling the cavity with a composition comprising at least one water-soluble or water-dispersible polymer as described above; (c) solidifying the composition, for example by drying at room temperature (optionally with heat) for a period of time such as several hours, to form a microneedle sheet; (d) removing the microneedle sheet from the mold; It can be prepared by a method comprising:

[0136] The mold may be made from organic materials such as polyamide and silicone, and / or inorganic materials such as aluminum and steel.

[0137] If necessary, at least one evaporative liquid component may be included in the above composition to enhance the fluidity of the composition. Examples of the evaporative liquid component are not limited, but may be preferably water and alcohol such as ethanol.

[0138] The amount of the evaporative liquid component may be 10% by mass or more, preferably 20% by mass or more, more preferably 30% by mass or more, based on the total mass of the composition. The amount of the evaporative liquid component may be 98% by mass or less, preferably 95% by mass or less, more preferably 90% by mass or less, based on the total mass of the composition. Therefore, the amount of the evaporative liquid component may be 10% by mass to 98% by mass, preferably 20% by mass to 95% by mass, more preferably 30% by mass to 90% by mass, based on the total mass of the composition.

[0139] The amount of water-soluble or water-dispersible polymer in the above composition, which is preferably flowable and more preferably in liquid form, may be from 2% to 90% by weight, preferably from 5% to 50% by weight, more preferably from 5% to 30% by weight, based on the total weight of the composition.

[0140] If desired, the composition may comprise at least one additional polymer, such as a swellable polymer as described above, and / or at least one polyol, and / or at least one cosmetically active ingredient, as described above.

[0141] The microneedles and the base layer can be prepared simultaneously by the above-mentioned molding method. In this case, it is preferred that the mold also has a cavity for the base layer, and the cavity for the microneedles in the mold is connected to the cavity for the base layer. Therefore, the base layer and the microneedles can be prepared as a single component.

[0142] When the microneedles and the substrate layer of the microneedle sheet are different or separate components, the microneedles may be prepared by the molding methods described above and fixed onto a separately formed substrate layer.

[0143] The shape of the microneedle sheet used for the present invention is not limited, and it may be any shape, such as the shape of the lips, or a shape suitable for application on the face, depending on the application target of the microneedle sheet.

[0144] {Applicator} A kit according to the present invention comprises at least one applicator.

[0145] The applicator comprises at least one application surface. The application surface of the applicator can be applied to keratinous materials such as the skin, especially the skin of the face, as well as the lips. The application surface of the applicator can come into contact with the keratinous materials.

[0146] The substrate layer of the microneedle sheet can be attached to the application surface of the applicator. Thus, the microneedle sheet can be attached to the application surface.

[0147] The means for attaching the base layer of the microneedle sheet to the application surface of the applicator is not limited. For example, the application surface of the applicator may have a convex surface, and the base layer of the microneedle may be inserted into the convex surface.

[0148] It is preferred that the substrate layer of the microneedle sheet is attachable to the application surface of the applicator with an adhesive, more preferably with an adhesive that is peelable or removable from the application surface, and even more preferably with a pressure sensitive adhesive.

[0149] It is preferred that the microneedle sheet comprises at least one adhesive layer, the adhesive layer of the microneedle sheet being attached to the application surface of the applicator.

[0150] For example, with respect to the example shown in FIG. 1, when the microneedle sheet 1 is used, the release layer 1-5 is peeled off from the surface of the adhesive layer 1-4, and the adhesive layer 1-4 is attached to the application surface of an applicator.

[0151] The application surface may be planar or curved (non-planar).

[0152] The type of applicator is not limited as long as the applicator has at least one application surface.

[0153] When the application surface is curved, for example, an applicator comprising at least one cylindrical roller having a curved side (wherein the curved side of the cylindrical roller comprises the application surface) may be used as the applicator.

[0154] An example of such an applicator is shown in Figure 2. The applicator 2 shown in Figure 2 has a roller 2-1 with a curved side 2-1-1, and the curved side 2-1-1 of the roller 2-1 provides an application surface to which a substrate layer of a microneedle sheet can be attached.

[0155] The applicator 2 also has a handle 2-2. A user of the applicator 2 can use the applicator 2 by grasping the handle 2-2.

[0156] When the microneedle sheet is used, the substrate layer of the microneedle sheet is attached to the application surface on the curved side 2-1-1 of the applicator 2.

[0157] 3 shows an applicator 2 to which a substrate layer of a microneedle sheet 1 is attached. The microneedle sheet 1 is attached to an application surface on the curved side of a roller 2-1 such that the substrate layer of the microneedle sheet 1 is in contact with the application surface. Thus, the microneedles of the microneedle sheet 1 can stand on the curved side of the roller 2.

[0158] At least a part of the curved side surface of the roller 2-1 may be covered with the microneedle sheet 1. It is preferable that the entire curved side surface of the roller 2-1 is covered with the microneedle sheet 1.

[0159] FIG. 4 shows how an applicator 2 having a microneedle sheet 1 is used.

[0160] When the microneedle sheet 1 is used, as shown in FIG. 3, the substrate layer of the microneedle sheet 1 is attached to the application surface of the curved side of a roller 2-1, and the applicator 2 having the microneedle sheet 1 is applied onto a keratinous material 3, such as skin, so that the roller 2-1 rolls over the keratinous material 3.

[0161] The microneedles of the microneedle sheet 1 on the applicator 2 can penetrate into keratinous material to provide the microneedle-derived cosmetic effect to the keratinous material.

[0162] On the other hand, if the application surface is a plane, for example an applicator comprising at least one stamp having at least one plane (wherein said plane comprises the application surface) can be used as the applicator.

[0163] The shape of the application surface is not limited: the application surface may be of any shape, such as round, rectangular and triangular, depending on the target zone of application.

[0164] An example of such an applicator is shown in Figure 5. The applicator 2' shown in Figure 5 has a stamp 2'-1 having a flat bottom surface 2'-1-1 which provides an application surface to which a substrate layer of a microneedle sheet can be attached.

[0165] The applicator 2' also has a handle 2'-2. A user of the applicator 2' can grasp the handle 2'-2 to use the applicator 2'.

[0166] When the microneedle sheet is used, it is attached to an application surface on the flat bottom surface 2'-1-1 of the stamp 2'-1 such that the base layer of the microneedle sheet is in contact with the application surface, so that the microneedles of the microneedle sheet can stand on the flat bottom surface 2'-1-1 of the stamp 2'-1.

[0167] At least a part of the flat bottom surface 2'-1-1 of the stamp 2'-1 may be covered with the microneedle sheet, but it is preferred that the entire flat bottom surface 2'-1-1 of the stamp 2'-1 is covered with the microneedle sheet.

[0168] After the substrate layer of the microneedle sheet is attached to the application surface of the flat bottom surface 2'-1-1 of the stamp 2'-1, the applicator 2' having the microneedle sheet is applied onto a keratinous material 3 such as skin so that the flat bottom surface 2'-1-1 of the stamp 2'-1 having the microneedles can be stamped onto the keratinous material such as skin.

[0169] The microneedles of the microneedle sheet on the applicator 2' can penetrate into keratinous material to provide the microneedle-derived cosmetic effect to the keratinous material.

[0170] {container} A kit according to the invention may comprise at least one container.

[0171] In order to protect the microneedle sheet, in particular the microneedles of the microneedle sheet, the container can be provided with the microneedle sheet, so that safe storage of the microneedle sheet can be performed without breaking the microneedles.

[0172] It is preferred that the container comprises at least one flexible and / or porous article: the microneedles of the microneedle sheet can penetrate securely into the flexible article or can rest in the pores of the porous article when not in use.

[0173] A soft and / or porous article can reduce or eliminate damage to the microneedles, and therefore the use of a soft and / or porous article can better protect the microneedles.

[0174] The flexible article may be composed of at least one flexible synthetic resin, which may be selected from polyurethane, polystyrene, polycarbonate, polyethylene terephthalate, poly(ethylene-co-vinyl alcohol), polyethylene, polyester, polyamide, and combinations thereof, which may include at least one softener.

[0175] The porous article may be composed of fibers. The fibers may be made from natural fibers such as cotton, semi-natural materials such as viscose, synthetic fibers such as polyester and polypropylene fibers, and combinations thereof. The porous article may be selected from woven or non-woven fabrics.

[0176] The soft, porous article may consist of a sponge, which may be made of a foamed synthetic resin, such as a foamed flexible polyurethane.

[0177] It is preferred that the flexible and / or porous article is in the form of a sheet. The flexible and / or porous sheet must have a thickness greater than the height of the microneedles. For example, if the microneedles have a height of 100-400 microns, the thickness of the flexible and / or porous sheet must be 200-500 microns.

[0178] Fig. 6 shows an example of a container. In Fig. 6, the container 4 is in the form of a tray having an opening. The material of the container 4 is not limited. For example, at least one selected from metal and synthetic resin can be used as the material of the container 4.

[0179] 6, the container 4 comprises a porous sheet 5. The porous sheet 5 is made of a sponge, or a woven or non-woven fabric.

[0180] 6, when the microneedle sheet 1 is not in use, the microneedle sheet 1 is stored in a container 4, and the microneedles of the microneedle sheet 1 can penetrate into the porous sheet 5 to be protected. Therefore, the microneedle sheet 1 can be stored with the microneedles protected.

[0181] It may be preferable for the microneedle sheet in the container to be packaged by covering the opening of the container 4, or both the opening of the container 4 and the container 4 itself, with a thin film, for example a thin transparent plastic film.

[0182] {Cosmetic Composition} A kit according to the present invention may comprise at least one cosmetic composition.

[0183] The cosmetic composition may be used as a pre- or post-treatment composition for keratinous materials.

[0184] The cosmetic composition may comprise at least one oil and water, preferably in the form of an O / W emulsion.

[0185] (oil) The cosmetic compositions that can be used for the present invention may comprise at least one oil. If two or more oils are used, they may be the same or different.

[0186] In this specification, "oil" means a fatty compound or substance that is in the form of a liquid or paste (non-solid) at room temperature (25°C) under atmospheric pressure (760 mmHg). As oils, those commonly used in cosmetics can be used, either alone or in combination. These oils can be volatile or non-volatile.

[0187] The oil may be a non-polar oil such as a hydrocarbon oil, a silicone oil, a polar oil such as a vegetable oil or an animal oil and an ester oil or an ether oil, or a mixture thereof.

[0188] The oil may be selected from the group consisting of oils of vegetable or animal origin, synthetic oils, silicone oils, hydrocarbon oils, and fatty alcohols.

[0189] Examples of vegetable oils include, for example, linseed oil, camellia oil, macadamia nut oil, corn oil, mink oil, olive oil, avocado oil, camellia oil, castor oil, safflower oil, jojoba oil, sunflower oil, almond oil, rapeseed oil, sesame oil, soybean oil, peanut oil, and mixtures thereof.

[0190] Examples of animal oils include squalene and squalane.

[0191] Examples of synthetic oils include alkane oils such as isododecane and isohexadecane, ester oils, ether oils, and artificial triglycerides.

[0192] The ester oil is preferably a saturated or unsaturated, linear or branched C1-C 26 Aliphatic mono- or polyacids and saturated or unsaturated, linear or branched C1-C 26 It is a liquid ester of an aliphatic monoalcohol or polyalcohol, the total number of carbon atoms in the ester being 10 or more.

[0193] Preferably, in esters of monoalcohols, at least one of the alcohols and acids from which the esters of the invention are derived is branched.

[0194] Among the monoesters of monoacids and monoalcohols, mention may be made of ethyl palmitate, ethylhexyl palmitate, isopropyl palmitate, dicaprylyl carbonate, alkyl myristates such as isopropyl myristate or ethyl myristate, isocetyl stearate, 2-ethylhexyl isononanoate, isononyl isononanoate, isodecyl neopentanoate and isostearyl neopentanoate.

[0195] C4~C 22 Dicarboxylic or tricarboxylic acids and C1-C 22 Esters with alcohols, and esters of mono-, di- or tricarboxylic acids with non-sugar C4-C 26 Esters with dihydroxy, trihydroxy, tetrahydroxy or pentahydroxy alcohols may also be used.

[0196] Mention may in particular be made of diethyl sebacate, isopropyl lauroyl sarcosinate, diisopropyl sebacate, bis(2-ethylhexyl) sebacate, diisopropyl adipate, di-n-propyl adipate, dioctyl adipate, bis(2-ethylhexyl) adipate, diisostearyl adipate, bis(2-ethylhexyl) maleate, triisopropyl citrate, triisocetyl citrate, triisostearyl citrate, glyceryl trilactate, glyceryl trioctanoate, trioctyldodecyl citrate, trioleyl citrate, neopentyl glycol diheptanoate, diethylene glycol diisononanoate.

[0197] As ester oil, C6-C 30 , preferably C 12 ~C 22Sugar esters and diesters of fatty acids of the above groups can be used. It is recalled that the term "sugar" means an oxygen-bearing hydrocarbon-based compound containing several alcohol functional groups, with or without aldehyde or ketone functional groups, and containing at least four carbon atoms. These sugars may be monosaccharides, oligosaccharides or polysaccharides.

[0198] Examples of suitable sugars that may be mentioned include sucrose (or sucrose), glucose, galactose, ribose, fucose, maltose, fructose, mannose, arabinose, xylose and lactose, as well as derivatives thereof, in particular alkyl derivatives such as methyl derivatives, e.g. methylglucose.

[0199] Sugar esters of fatty acids are made by combining the aforementioned sugars with linear or branched, saturated or unsaturated C6-C 30 , preferably C 12 ~C 22 and mixtures of esters with fatty acids of the formula: When they are unsaturated, these compounds can have 1 to 3 conjugated or non-conjugated carbon-carbon double bonds.

[0200] The esters according to this variant may also be chosen from monoesters, diesters, triesters, tetraesters and polyesters, and mixtures thereof.

[0201] These esters may be, for example, oleate, laurate, palmitate, myristate, behenate, coconutate, stearate, linoleate, linolenate, caprate and arachidonic acid esters, or mixtures thereof, such as, in particular, the mixed esters of oleopalmitate, oleostearate and palmitostearate, and pentaerythrityl tetraethylhexanoate.

[0202] More particularly, mono- and diesters are used, especially the mono- or dioleate, stearates, behenates, oleopalmitates, linoleates, linolenates, and oleostearates of sucrose, glucose, or methylglucose.

[0203] One example that may be mentioned is the product sold under the name Glucate® DO by the company Amerchol, which is a methylglucose dioleate.

[0204] Examples of preferred ester oils include, for example, diisopropyl adipate, dioctyl adipate, 2-ethylhexyl hexanoate, ethyl laurate, cetyl octanoate, octyldodecyl octanoate, isodecyl neopentanoate, myristyl propionate, 2-ethylhexyl 2-ethylhexanoate, 2-ethylhexyl octanoate, 2-ethylhexyl (caprylic acid / capric acid), methyl palmitate, ethyl palmitate, isopropyl palmitate, dicarbonate, and the like. Included are prilyl, isopropyl lauroyl sarcosinate, isononyl isononanoate, ethylhexyl palmitate, isohexyl laurate, hexyl laurate, isocetyl stearate, isopropyl isostearate, isopropyl myristate, isodecyl oleate, glyceryl tri(2-ethylhexanoate), pentaerythrityl tetra(2-ethylhexanoate), 2-ethylhexyl succinate, diethyl sebacate, and mixtures thereof.

[0205] Examples of artificial triglycerides include capryl caprylyl glyceride, glyceryl trimyristate, glyceryl tripalmitate, glyceryl trilinolenate, glyceryl trilaurate, glyceryl tricaprate, glyceryl tricaprylate, capric / caprylic triglyceride, and capric / caprylic / linolenic triglyceride.

[0206] Examples of silicone oils include linear organopolysiloxanes such as dimethylpolysiloxane, methylphenylpolysiloxane, methylhydrogenpolysiloxane, and the like; cyclic organopolysiloxanes such as cyclohexasiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, and the like; and mixtures thereof.

[0207] Preferably, the silicone oil is chosen from polydialkylsiloxane fluids, in particular polydimethylsiloxane fluids (PDMS) containing at least one aryl group, and polyorganosiloxane fluids.

[0208] These silicone oils may also be organically modified. The organically modified silicones that may be used according to the invention are silicone oils as defined above and which contain in their structure one or more organic functional groups linked via a hydrocarbon-based group.

[0209] Organopolysiloxanes are defined in detail in "Chemistry and Technology of Silicones" by Walter Noll, Academic Press (1968). They may be volatile or nonvolatile.

[0210] When they are volatile, the silicones are more particularly chosen from those having a boiling point between 60° C. and 260° C., and even more particularly chosen from: (i) cyclic polydialkylsiloxanes containing 3 to 7, preferably 4 to 5, silicon atoms. These are, for example, octamethylcyclotetrasiloxane, sold in particular under the name Volatile Silicone® 7207 by Union Carbide or under the name Silbione® 70045 V2 by Rhodia, decamethylcyclopentasiloxane, sold in particular under the name Volatile Silicone® 7158 by Union Carbide and under the name Silbione® 70045 V5 by Rhodia, and dodecamethylcyclopentasiloxane, sold under the name Silsoft 1217 by Momentive Performance Materials, and mixtures thereof. Polydialkylsiloxanes of the following formula:

[0211] [ka]

[0212] Mention may also be made of cyclocopolymers of the dimethylsiloxane / methylalkylsiloxane type. Mention may also be made of mixtures of cyclic polydialkylsiloxanes and organosilicon compounds, such as a 50 / 50 mixture of octamethylcyclotetrasiloxane and tetratrimethylsilylpentaerythritol, and a mixture of octamethylcyclotetrasiloxane and oxy-1,1'-bis(2,2,2',2',3,3'-hexatrimethylsilyloxy)neopentane, and (ii) Contains 2 to 9 silicon atoms and has a density of 5 × 10 at 25 °C -6 m 2Linear volatile polydialkylsiloxanes having a viscosity of less than 10000 / s. An example is decamethyltetrasiloxane, sold in particular under the name SH 200 by Toray Silicone. Silicones belonging to this class are also described in the article published in Cosmetics and Toiletries, Vol. 91, January 1976, pages 27-32, Todd & Byers, Volatile Silicone Fluids for Cosmetics. The viscosity of the silicones is measured at 25°C according to ASTM Standard 445 Appendix C.

[0213] Non-volatile polydialkylsiloxanes may also be used. These non-volatile silicones are more particularly chosen from the polydialkylsiloxanes, among which mention may be made mainly of the polydimethylsiloxanes containing trimethylsilyl end groups.

[0214] Among these polydialkylsiloxanes, mention may be made, but is not limited to, the following commercially available products: the Silbione® oils of the 47 and 70 047 series or Mirasil® oils sold by the company Rhodia, such as for example the 70 047 V 500 000 oil; the Mirasil® series of oils sold by the company Rhodia; - Dow Corning 200 series oils, e.g. with a viscosity of 60 000mm 2 / sec, DC200, and - Viscasil® oils manufactured by General Electric and certain oils of the SF series manufactured by General Electric (SF 96, SF 18).

[0215] Mention may also be made of polydimethylsiloxanes containing dimethylsilanol end groups, known under the name dimethiconol (CTFA), such as the 48 series oils from Rhodia.

[0216] Among the silicones containing aryl groups, mention may be made of the polydiarylsiloxanes, especially polydiphenylsiloxanes, and polyalkylarylsiloxanes, such as phenylsilicone oils.

[0217] Phenyl silicone oils have the formula:

[0218] [ka]

[0219] (In the formula, R1~R 10 are each independently a saturated or unsaturated, linear, cyclic or branched C1-C 30 Hydrocarbon group, preferably C1-C 12 a hydrocarbon group, more preferably a C1-C6 hydrocarbon group, in particular a methyl, ethyl, propyl or butyl group; m, n, p and q each independently represent an integer of 0 to 900, inclusive, preferably an integer of 0 to 500, inclusive, and more preferably an integer of 0 to 100, inclusive; However, the sum n+m+q is not 0. The phenyl silicone may be selected from the group consisting of phenyl silicones.

[0220] Examples that may be mentioned include products sold under the following names: - Rhodia Silbione® oils, series 70 641; Rhodorsil® 70 633 and 763 series oils from Rhodia; - Dow Corning 556 Cosmetic Grade Fluid oil, - PK series silicones from Bayer, e.g. PK20 product, - certain oils of the SF series manufactured by General Electric, such as SF 1023, SF 1154, SF 1250 and SF 1265.

[0221] As the phenyl silicone oil, phenyl trimethicone (wherein R1 to R 10 is methyl, p, q and n=0, and m=1.

[0222] The organically modified liquid silicones may in particular contain polyethyleneoxy and / or polypropyleneoxy groups. Mention may therefore be made of silicone KF-6017 proposed by Shin-Etsu Chemical Co., Ltd., and of Silwet® L722 and L77 oils from Union Carbide.

[0223] The hydrocarbon oil may be chosen from: - Linear or branched, optionally cyclic, C6-C 16 Lower alkanes. Examples that may be mentioned include hexane, undecane, dodecane, tridecane and isoparaffins, such as isohexadecane, isododecane and isodecane; and - linear or branched hydrocarbons containing more than 16 carbon atoms, such as liquid paraffin, petroleum jelly, polydecenes and hydrogenated polyisobutenes, such as Parleam®, and squalane.

[0224] Preferred examples of hydrocarbon oils include, for example, linear or branched hydrocarbons such as isohexadecane, isododecane, squalane, mineral oils (e.g., liquid paraffin), paraffin, petrolatum or petroleum, naphthalene, etc.; hydrogenated polyisobutene, isoeicosane and decene / butene copolymers; and mixtures thereof.

[0225] The term "fatty" in fatty alcohol means that it contains a relatively large number of carbon atoms. Thus, alcohols having 4 or more carbon atoms, preferably 6 or more, more preferably 12 or more carbon atoms are included within the scope of fatty alcohol. Fatty alcohols may be saturated or unsaturated. Fatty alcohols may be linear or branched.

[0226] The fatty alcohol may have the structure R-OH, where R is selected from saturated and unsaturated, linear and branched groups containing from 4 to 40 carbon atoms, preferably from 6 to 30 carbon atoms, and more preferably from 12 to 20 carbon atoms. In at least one embodiment, R is selected from C 12 ~C 20 Alkyl group and C 12 ~C 20 alkenyl groups, R may be unsubstituted or substituted with at least one hydroxyl group.

[0227] Examples of fatty alcohols include lauryl alcohol, cetyl alcohol, stearyl alcohol, isostearyl alcohol, behenyl alcohol, undecylenyl alcohol, myristyl alcohol, octyldodecanol, hexyldecanol, oleyl alcohol, linoleyl alcohol, palmitoleyl alcohol, arachidonyl alcohol, erucyl alcohol, and mixtures thereof.

[0228] Preferably, the fatty alcohol is a saturated fatty alcohol.

[0229] Therefore, fatty alcohols are linear or branched, saturated or unsaturated, C6-C 30 Alcohols, preferably linear or branched, saturated C6-C 30 Alcohols, more preferably linear or branched, saturated C 12 ~C 20 Alcohol can be selected.

[0230] The term "saturated fatty alcohol" as used herein means an alcohol having a long aliphatic saturated carbon chain. A saturated fatty alcohol is any linear or branched, saturated C-C 30 It is preferably selected from fatty alcohols, linear or branched, saturated C6-C 30 Among fatty alcohols, linear or branched, saturated C 12 ~C20 Fatty alcohols can be preferably used. Any linear or branched, saturated C 16 ~C 20 Fatty alcohols are more preferably used. 16 ~C 20 Fatty alcohols may even more preferably be used.

[0231] Examples of saturated fatty alcohols include lauryl alcohol, cetyl alcohol, stearyl alcohol, isostearyl alcohol, behenyl alcohol, undecylenyl alcohol, myristyl alcohol, octyldodecanol, hexyldecanol, and mixtures thereof. In one embodiment, cetyl alcohol, stearyl alcohol, octyldodecanol, hexyldecanol, or mixtures thereof (e.g., cetearyl alcohol), and behenyl alcohol can be used as the saturated fatty alcohol.

[0232] According to at least one embodiment, the fatty alcohols used in the cosmetic compositions that may be used for the present invention are preferably chosen from cetyl alcohol, octyldodecanol, hexyldecanol, and mixtures thereof.

[0233] It may be preferred that the oil is selected from ester oils, hydrocarbon oils, silicone oils, fatty alcohols, and mixtures thereof.

[0234] The amount of oil in the cosmetic composition that can be used for the present invention may be 1% by mass or more, preferably 5% by mass or more, more preferably 10% by mass or more, based on the total mass of the cosmetic composition. The amount of oil in the cosmetic composition that can be used for the present invention may be 30% by mass or less, preferably 25% by mass or less, more preferably 20% by mass or less, based on the total mass of the cosmetic composition. The amount of oil in the cosmetic composition that can be used for the present invention may be 1% by mass to 30% by mass, preferably 5% by mass to 25% by mass, more preferably 10% by mass to 20% by mass, based on the total mass of the cosmetic composition.

[0235] The oils may form the fatty phase of the cosmetic compositions that may be used for the present invention.

[0236] When the cosmetic composition that can be used for the present invention is in the form of an O / W emulsion, the oil can form a dispersed fatty phase in the O / W emulsion.

[0237] (water) The cosmetic composition that can be used for the present invention may contain water.

[0238] The amount of water may be 50% by mass or more, preferably 55% by mass or more, more preferably 60% by mass or more, based on the total mass of the cosmetic composition. The amount of water may be 95% by mass or less, preferably 90% by mass or less, more preferably 85% by mass or less, based on the total mass of the cosmetic composition. The amount of water in the cosmetic composition that can be used for the present invention may be in the range of 50% by mass to 95% by mass, preferably 55% by mass to 90% by mass, more preferably 60% by mass to 85% by mass, based on the total mass of the cosmetic composition.

[0239] Water may form the aqueous phase of the cosmetic composition that may be used for the present invention.

[0240] When the cosmetic composition that can be used for the present invention is in the form of an O / W emulsion, water can form the continuous aqueous phase in the O / W emulsion.

[0241] (Surfactant) The cosmetic composition that can be used for the present invention may comprise at least one surfactant. When two or more surfactants are used, they may be the same or different.

[0242] Any surfactant can be used for the present invention. The surfactant that can be used in the present invention can be selected from the group consisting of anionic surfactants, amphoteric surfactants, cationic surfactants and nonionic surfactants. Two or more surfactants can be used in combination. Therefore, a single type of surfactant or a combination of different types of surfactants can be used.

[0243] Anionic Surfactants According to the present invention, the type of anionic surfactant is not limited. 30 ) Alkyl sulfate, (C6-C 30 ) Alkyl ether sulfate, (C6-C 30 ) Alkyl amide ether sulfates, alkyl aryl polyether sulfates and monoglyceride sulfates; (C6-C 30 ) Alkyl sulfonate, (C6-C 30 ) Alkyl amidosulfonate, (C6-C 30 ) alkylarylsulfonates, α-olefinsulfonates and paraffin sulfonates; (C6-C 30 ) Alkyl phosphate;(C6-C 30 ) Alkyl sulfosuccinate, (C6-C 30 ) Alkyl ether sulfosuccinates and (C6-C 30 ) Alkyl amide sulfosuccinate; (C6-C 30 ) Alkyl sulfoacetate; (C6-C 24 ) Acyl sarcosinate; (C6-C 24 ) Acyl glutamate; (C6-C 30 ) Alkyl polyglycoside carboxyl ether; (C6-C 30 ) Alkyl polyglycoside sulfosuccinate; (C6-C 30 ) Alkyl sulfosuccinamate; (C6-C 24 )Acyl isethionate;N-(C6-C 24 ) Acyl taurate; C6~C 30 Fatty acid salts; coconut oil salts or hydrogenated coconut oil salts; (C8-C 20) Acyl lactate; (C6-C 30 ) Alkyl-D-galactosiduronic acid salts; Polyoxyalkylenated (C6-C 30 ) Alkyl ether carboxylate; Polyoxyalkylenated (C6-C 30 ) alkyl aryl ether carboxylates; and polyoxyalkylenated (C6-C 30 ) alkyl amide ether carboxylates.

[0244] The anionic surfactant is (C6-C 30 ) alkyl sulfate or polyoxyalkylenated (C6-C 30 ) alkyl ether carboxylates.

[0245] In at least one embodiment, the anionic surfactant is in the form of a salt, such as an alkali metal (e.g., sodium) salt, an alkaline earth metal (e.g., magnesium) salt, an ammonium salt, an amine salt, and an amino alcohol salt. Under some conditions, the anionic surfactant may be in the form of an acid.

[0246] Amphoteric surfactants According to the present invention, the type of amphoteric surfactant is not limited. The amphoteric or zwitterionic surfactant may be, for example (non-limiting list), an amine derivative, such as an aliphatic secondary or tertiary amine, and optionally quaternized, where the aliphatic group is a straight or branched chain containing 8 to 22 carbon atoms and at least one water-solubilizing anionic group (e.g., carboxylate, sulfonate, sulfate, phosphate or phosphonate).

[0247] The amphoteric surfactant may preferably be selected from the group consisting of betaines and amidoamine carboxylated derivatives.

[0248] The betaine type amphoteric surfactants include alkyl betaines, alkyl amido alkyl betaines, sulfo betaines, phospho betaines and alkyl amido alkyl sulfo betaines, specifically (C8 to C 24 ) Alkyl betaine, (C8-C 24 ) Alkylamide (C1-C8) alkyl betaine, sulfobetaine and (C8-C 24 In one embodiment, the betaine type amphoteric surfactant is preferably selected from the group consisting of (C8-C) alkylamide (C1-C8) alkylsulfobetaines. 24 ) Alkyl betaine, (C8-C 24 ) alkylamide (C1-C8) alkyl sulfobetaines, sulfobetaines and phosphobetaines.

[0249] Non-limiting examples that may be mentioned include the compounds classified in the CTFA Dictionary, 9th Edition, 2002, alone or in mixtures, under the names coco betaine, lauryl betaine, cetyl betaine, coco / oleamidopropyl betaine, cocamidopropyl betaine, palmitamidopropyl betaine, stearamidopropyl betaine, cocamidoethyl betaine, cocamidopropyl hydroxysultaine, oleamidopropyl hydroxysultaine, coco hydroxysultaine, lauryl hydroxysultaine and coco sultaine.

[0250] The betaine type amphoteric surfactants are preferably alkyl betaines and alkylamidoalkyl betaines, in particular coco betaine and cocamidopropyl betaine.

[0251] Among the amidoamine carboxylated derivatives, mention may be made of the products sold under the name Miranol, which are described in U.S. Pat. Nos. 2,528,378 and 2,781,354 and which are classified in the CTFA Dictionary, Third Edition, 1982, the disclosure of which is incorporated herein by reference, under the names amphocarboxyglycinates and amphocarboxypropionates, respectively having the following structures: R1-CONHCH2CH2-N +(R2)(R3)(CH2COO - ) (In the formula, R1 represents the alkyl group of the acid R1-COOH present in the hydrolyzed coconut oil, a heptyl, nonyl or undecyl group; R2 represents a β-hydroxyethyl group; R3 represents a carboxymethyl group. and R1'-CONHCH2CH2-N(B)(C) (In the formula, B represents -CH2CH2OX'; C is -(CH2) z -Y', where z=1 or 2; X' represents a -CH2CH2-COOH group, -CH2-COOZ', -CH2CH2-COOH, -CH2CH2-COOZ' or a hydrogen atom; Y' represents a -COOH group, a -COOZ' group, a -CH2-CHOH-SO3Z' group or a -CH2-CHOH-SO3H group; Z' represents an ion of an alkali metal or alkaline earth metal, such as sodium, an ammonium ion, or an ion derived from an organic amine; R1' is the alkyl group of the acid R1'-COOH present in coconut oil or hydrolyzed linseed oil, C7, C9, C 11 Or C 13 Alkyl groups such as alkyl groups, C 17 Alkyl groups and their isoforms, or unsaturated C 17 (indicating the group)

[0252] The amphoteric surfactant is (C8-C 24 ) Alkyl amphomonoacetate, (C8-C 24 ) Alkyl amphodiacetate, (C8-C 24 ) Alkyl amphomonopropionate and (C8-C 24 ) alkyl amphodipropionates.

[0253] These compounds are classified in the CTFA Dictionary, 5th Edition, 1993 under the names disodium cocoamphodiacetate, disodium lauroamphodiacetate, disodium caprylamphodiacetate, disodium capryloamphodiacetate, disodium cocoamphodipropionate, disodium lauroamphopropionate, disodium caprylamphodipropionate, lauroamphodipropionic acid and cocoamphodipropionic acid.

[0254] Mention may be made, by way of example, of cocoamphodiacetate sold under the trade name Miranol® C2M concentrate by the company Rhodia Chimie.

[0255] Cationic Surfactants According to the present invention, the type of cationic surfactant is not limited. The cationic surfactant can be selected from the group consisting of optionally polyoxyalkylenated primary, secondary and tertiary fatty amine salts, quaternary ammonium salts, and mixtures thereof.

[0256] Examples of quaternary ammonium salts that may be mentioned include, but are not limited to, the following: of the following general formula (I):

[0257] [ka]

[0258] [In the formula, R1, R2, R3 and R4 may be the same or different and are selected from linear and branched aliphatic groups containing 1 to 30 carbon atoms and optionally containing heteroatoms such as oxygen, nitrogen, sulfur and halogens. Aliphatic groups include, for example, alkyl, alkoxy, C2-C6 polyoxyalkylene, alkylamide, (C 12 ~C 22 ) alkylamide (C2-C6) alkyl, (C 12 ~C 22) alkyl acetate and hydroxyalkyl groups; and aromatic groups, such as aryl and alkylaryl; X - is selected from a halide ion, a phosphate ion, an acetate ion, a lactate ion, a (C2-C6) alkyl sulfate ion, and an alkyl sulfonate ion or an alkylaryl sulfonate ion; Quaternary ammonium salts of imidazolines, such as those of the following formula (II):

[0259] [ka]

[0260] (In the formula, R5 is selected from alkenyl and alkyl groups containing 8 to 30 carbon atoms, for example tallow or coconut fatty acid derivatives; R6 is selected from hydrogen, C1-C4 alkyl groups, and alkenyl and alkyl groups containing 8 to 30 carbon atoms; R7 is selected from C1 to C4 alkyl groups; R8 is selected from hydrogen and C1-C4 alkyl groups; X - is selected from halide ions, phosphate ions, acetate ions, lactate ions, alkyl sulfate ions, alkyl sulfonate ions and alkylaryl sulfonate ions). In one embodiment, R5 and R6 are a mixture of groups selected from alkenyl and alkyl groups containing 12 to 21 carbon atoms, such as fatty acid derivatives of tallow, R7 is methyl and R8 is hydrogen. Examples of such products include, but are not limited to, Quaternium-27 (CTFA 1997) and Quaternium-83 (CTFA 1997), sold by Witco under the names "Rewoquat®" W75, W90, W75PG and W75HPG; Diquaternary ammonium salt of formula (III)

[0261] [ka]

[0262] (In the formula, R9 is selected from an aliphatic group containing 16 to 30 carbon atoms; R 10 is hydrogen or an alkyl group containing 1 to 4 carbon atoms, or (R 16a )(R 17a )(R 18a )N + (CH2)3 groups, R 11 , R 12 , R 13 , R 14 , R 16a , R 17a and R 18a are the same or different and are selected from hydrogen and alkyl groups containing 1 to 4 carbon atoms; X - is selected from the group consisting of halide ions, acetate ions, phosphate ions, nitrate ions, ethyl sulfate ions and methyl sulfate ions). Examples of such diquaternary ammonium salts are FINQUAT CT-P (quaternium-89) from FINETEX, or FINQUAT CT (quaternium-75) from FINETEX; and Quaternary ammonium salts containing at least one ester functional group, such as those of formula (IV):

[0263] [ka]

[0264] (In the formula, R 22 is selected from C1 to C6 alkyl groups, and C1 to C6 hydroxyalkyl groups and dihydroxyalkyl groups; R 23 teeth, The following groups:

[0265] [ka]

[0266] , linear and branched, saturated and unsaturated C1-C 22 Hydrocarbon group R 27 and hydrogen; R 25 teeth, The following groups:

[0267] [ka]

[0268] , linear and branched, saturated and unsaturated C1-C6 hydrocarbon radicals R 29 and hydrogen; R 24 , R 26 and R 28 may be the same or different, and are linear and branched, saturated and unsaturated C7-C 21 selected from hydrocarbon groups, r, s and t may be the same or different and are selected from integers ranging from 2 to 6; Each of r1 and t1 may be the same or different and is 0 or 1, and r2+r1=2r and t1+2t=2t; y is selected from an integer ranging from 1 to 10; x and z may be the same or different and are selected from integers ranging from 0 to 10; X - is selected from organic and inorganic anions, both simple and complex, where the sum x+y+z is in the range of 1 to 15, and when x is 0, R 23 is R 27 When z is 0, R 25 is R 29 R 22 can be selected from linear and branched alkyl groups. In one embodiment, R 22 is selected from linear alkyl groups. 22is selected from methyl, ethyl, hydroxyethyl and dihydroxypropyl groups, for example, methyl and ethyl groups. In one embodiment, the sum x+y+z is in the range of 1 to 10. R 23 is a hydrocarbon group R 27 When R is , it may be a long chain containing 12 to 22 carbon atoms, or a short chain containing 1 to 3 carbon atoms. 25 is a hydrocarbon group R 29 When R 24 , R 26 and R 28 may be the same or different, linear and branched, saturated and unsaturated C 11 ~C 21 Selected from hydrocarbon-based groups, for example linear and branched, saturated and unsaturated C 11 ~C 21 In another embodiment, x and z are the same or different and are equal to 0 or 1. In one embodiment, y is equal to 1. In another embodiment, r, s and t are the same or different and are equal to 2 or 3, for example, equal to 2. The anion X - can be selected from, for example, halides, such as chloride, bromide and iodide; and C1-C4 alkyl sulfates, such as methyl sulfate. However, methanesulfonate, phosphate, nitrate, tosylate, anions derived from organic acids, such as acetate and lactate, and any other anion compatible with ammonium containing an ester function, are other non-limiting examples of anions that may be used according to the present invention. In one embodiment, the anion X - is selected from chloride ion and methyl sulfate ion.

[0269] In another embodiment, an ammonium salt of formula (IV) may be used, wherein R 22 is selected from a methyl group and an ethyl group, x and y are equal to 1, z is equal to 0 or 1, r, s and t are equal to 2, R 23 teeth, The following groups:

[0270] [ka]

[0271] , methyl group, ethyl group, and C 14 ~C 22 selected from a hydrocarbon group and hydrogen; R 25 teeth, The following groups:

[0272] [ka]

[0273] and hydrogen; R 24 , R 26 and R 28 may be the same or different, linear and branched, saturated and unsaturated C 13 ~C 17 Selected from hydrocarbon-based groups, for example linear and branched, saturated and unsaturated C 13 ~C 17 It is selected from an alkyl group and an alkenyl group.

[0274] In one embodiment, the hydrocarbon-based group is linear.

[0275] Non-limiting examples of compounds of formula (IV) that may be mentioned include salts such as the chloride and methyl sulfate of diacyloxyethyl-dimethylammonium, the chloride and methyl sulfate of diacyloxyethyl-hydroxyethyl-methylammonium, the chloride and methyl sulfate of monoacyloxyethyl-dihydroxyethyl-methylammonium, the chloride and methyl sulfate of triacyloxyethyl-methylammonium, the chloride and methyl sulfate of monoacyloxyethyl-hydroxyethyl-dimethyl-ammonium, and mixtures thereof. In one embodiment, the acyl group may contain 14 to 18 carbon atoms and may be derived, for example, from vegetable oils, such as palm oil and sunflower oil. When the compound contains several acyl groups, these groups may be the same or different.

[0276] These products can be obtained, for example, by direct esterification of triethanolamine, triisopropanolamine, alkyldiethanolamine or alkyldiisopropanolamine, optionally oxyalkylenated, with fatty acids or with mixtures of fatty acids of vegetable or animal origin, or by transesterification of their methyl esters. This esterification can be followed by quaternization using an alkylating agent selected from alkyl halides, such as methyl and ethyl halides; dialkyl sulfates, such as dimethyl and diethyl sulfate; methyl methanesulfonate; methyl para-toluenesulfonate; glycol chlorohydrins; and glycerol chlorohydrins.

[0277] Such compounds are sold, for example, by the company Cognis under the name Dehyquart®, by the company Stepan under the name Stepanquat®, by the company Ceca under the name Noxamium® and by the company Rewo-Goldschmidt under the name "Rewoquat® WE 18".

[0278] Other non-limiting examples of ammonium salts that can be used in the cosmetic compositions that can be used for the present invention include ammonium salts containing at least one ester functional group, as described in U.S. Pat. Nos. 4,874,554 and 4,137,180.

[0279] The above-mentioned quaternary ammonium salts that can be used in the cosmetic compositions that can be used for the present invention include, but are not limited to, those corresponding to formula (I), such as tetraalkylammonium chlorides, such as dialkyldimethylammonium chloride and alkyltrimethylammonium chloride (wherein the alkyl group contains from about 12 to 22 carbon atoms), such as behenyltrimethylammonium chloride, distearyldimethylammonium chloride, cetyltrimethylammonium chloride and benzyldimethylstearylammonium chloride; palmitylamidopropyltrimethylammonium chloride; and stearamidopropyldimethyl(myristyl acetate)ammonium chloride sold under the name "Ceraphyl® 70" by the company Van Dyk.

[0280] According to one embodiment, the cationic surfactants that can be used in the cosmetic compositions that can be used for the present invention are selected from quaternary ammonium salts, such as behenyltrimethylammonium chloride, cetyltrimethylammonium chloride, quaternium-83, quaternium-87, quaternium-22, behenylamidopropyl-2,3-dihydroxypropyldimethylammonium chloride, palmitylamidopropyltrimethylammonium chloride and stearamidopropyldimethylamine.

[0281] Nonionic Surfactants Nonionic surfactants are compounds known per se (see, for example, in this respect, "Handbook of Surfactants" by MR Porter, Blackie & Son publishers (Glasgow and London), 1991, pages 116-178). Thus, the nonionic surfactants can be chosen, for example, from esters of alcohols, α-diols, alkylphenols and fatty acids, which compounds can be ethoxylated, propoxylated or glycerolized and have, for example, at least one fatty chain containing from 8 to 30 carbon atoms, the number of ethylene oxide or propylene oxide groups ranging from 2 to 50 and the number of glycerol groups ranging from 1 to 30. Mention can also be made of maltose derivatives. Copolymers of ethylene oxide and / or propylene oxide;Condensates of ethylene oxide and / or propylene oxide with fatty alcohols;Polyethoxylated fatty amides, for example containing 2 to 30 moles of ethylene oxide;Polyglycerolated fatty amides, for example containing 1.5 to 5, for example 1.5 to 4 glycerol groups;Ethoxylated fatty acid esters of sorbitan, containing 2 to 30 moles of ethylene oxide;Ethoxylated oils of vegetable origin;Fatty acid esters of sucrose;Fatty acid esters of polyethylene glycol;Glycerol (C6-C 24 ) alkyl polyglycosides, polyethoxylated fatty acid monoesters or diesters; N-(C6-C 24 ) alkylglucamine derivatives; (C 10 ~C 14 ) alkylamine oxide or N-(C 10 ~C 14 ) amine oxides such as acylaminopropylmorpholine oxide; and mixtures thereof.

[0282] The non-ionic surfactants may preferably be chosen from monooxyalkylenated, polyoxyalkylenated, monoglycerolated or polyglycerolated non-ionic surfactants, the oxyalkylene units being more particularly oxyethylene or oxypropylene units or combinations thereof, preferably oxyethylene units.

[0283] Examples of monooxyalkylenated or polyoxyalkylenated nonionic surfactants that may be mentioned include, especially alone or in mixtures, the following: Monooxyalkylenated or polyoxyalkylenated (C8-C 24 ) alkylphenols, Saturated or unsaturated, linear or branched, monooxyalkylenated or polyoxyalkylenated C8-C 30 alcohol, Saturated or unsaturated, linear or branched, monooxyalkylenated or polyoxyalkylenated C8-C 30 Amides, Saturated or unsaturated, linear or branched, C8-C 30 esters of acids and polyalkylene glycols; Saturated or unsaturated, linear or branched, C8-C 30 Monooxyalkylenated or polyoxyalkylenated esters of acids with sorbitol, Saturated or unsaturated, monooxyalkylenated or polyoxyalkylenated vegetable oils, Condensation products of ethylene oxide and / or propylene oxide.

[0284] The surfactant preferably contains a number of moles of ethylene oxide and / or propylene oxide between 1 and 100, most preferably between 2 and 50. Advantageously, the non-ionic surfactant does not contain any oxypropylene units.

[0285] According to one embodiment of the invention, the polyoxyalkylenated nonionic surfactant is selected from polyoxyethylenated fatty alcohols (polyethylene glycol ethers of fatty alcohols), polyoxyethylenated fatty esters (polyethylene glycol esters of fatty acids), and mixtures of polyoxyethylenated fatty alcohols and polyoxyethylenated fatty esters.

[0286] Polyoxyethylenated fatty alcohols (or C8-C 30 Examples of the ethylene oxide adducts of lauryl alcohol, in particular those containing 2 to 50 oxyethylene units, more particularly those containing 2 to 20 oxyethylene units (CTFA names Laureth-2 to Laureth-20); ethylene oxide adducts of behenyl alcohol, in particular those containing 2 to 50 oxyethylene units, more particularly those containing 2 to 20 oxyethylene units (CTFA names Beheneth-2 to Beheneth-20); ethylene oxide adducts of cetearyl alcohol (mixtures of cetyl alcohol and stearyl alcohol), in particular those containing 2 to 30 oxyethylene units (CTFA names Beheneth-2 to Beheneth-20); Ceteareth-2 to Ceteareth-30 (CTFA names); ethylene oxide adducts of cetyl alcohol, especially those containing 2 to 30 oxyethylene units (Ceteth-2 to Ceteth-30 (CTFA names); ethylene oxide adducts of stearyl alcohol, especially those containing 2 to 50 oxyethylene units, more especially those containing 2 to 20 oxyethylene units (CTFA names Steareth-2 to Steareth-20); ethylene oxide adducts of isostearyl alcohol, especially those containing 2 to 50 oxyethylene units (CTFA names Isosteareth-2 to Isosteareth-50); and mixtures thereof.

[0287] Examples of polyoxyethylenated fatty esters that may be mentioned include ethylene oxide adducts with esters of lauric acid, palmitic acid, stearic acid or behenic acid and mixtures thereof, in particular those containing from 9 to 100 oxyethylene units, such as PEG-9 to PEG-50 laurate (CTFA names: PEG-9 laurate to PEG-50 laurate); PEG-9 to PEG-50 palmitate (CTFA names: PEG-9 palmitate to PEG-50 palmitate); PEG-9 to PEG-50 stearate (CTFA names: PEG-9 stearate to PEG-50 stearate); PEG-9 to PEG-50 palmitostearate; PEG-9 to PEG-50 behenate (CTFA names: PEG-9 behenate to PEG-50 behenate); Polyethylene glycol 100 EO monostearate (CTFA name: PEG-100 stearate); and mixtures thereof.

[0288] According to one preferred embodiment of the invention, the cosmetic composition that may be used for the invention comprises at least one polyoxyethylenated fatty alcohol.

[0289] According to a more preferred embodiment, the cosmetic composition that can be used for the present invention contains at least one fatty alcohol containing from 2 to 9 ethylene oxide units and at least one fatty alcohol containing from 10 to 30 ethylene oxide units.

[0290] Examples of monoglycerolated or polyglycerolated nonionic surfactants include monoglycerolated or polyglycerolated C8-C 40 Alcohol is preferably used.

[0291] In particular, monoglycerolized or polyglycerolized C8-C 40 The alcohol has the formula: RO-[CH2-CH(CH2OH)-O] m -H, or RO-[CH(CH2OH)-CH2O] m -H (In the formula, R is a linear or branched C8-C 40 , preferably C8 to C 30 represents an alkyl group or an alkenyl group, and m represents a number ranging from 1 to 30, preferably from 1.5 to 10. is equivalent to.

[0292] Examples of compounds that are suitable in the context of the present invention include lauryl alcohol containing 4 moles of glycerol (INCI name: Polyglyceryl-4 lauryl ether), lauryl alcohol containing 1.5 moles of glycerol, oleyl alcohol containing 4 moles of glycerol (INCI name: Polyglyceryl-4 oleyl ether), oleyl alcohol containing 2 moles of glycerol (INCI name: Polyglyceryl-2 oleyl ether), cetearyl alcohol containing 2 moles of glycerol, cetearyl alcohol containing 6 moles of glycerol, oleocetyl alcohol containing 6 moles of glycerol, and octadecanol containing 6 moles of glycerol.

[0293] The alcohol may represent a mixture of alcohols, just as the value of m represents a statistical value, which means that in a commercial product, several types of polyglycerolized fatty alcohols can coexist in the form of a mixture.

[0294] Among the monoglycerolated or polyglycerolated alcohols, C8 / C containing 1 mole of glycerol 10 Alcohol, C containing 1 mole of glycerol 10 / C 12 C containing alcohol and 1.5 moles of glycerol 12 It is preferred to use alcohol.

[0295] Monoglycerolized or polyglycerolized C8-C 40 The fatty ester has the formula: R'O-[CH2-CH(CH2OR''')-O] m -R'', or R'O-[CH(CH2OR''')-CH2O] m-R'' [In the formula, R', R'' and R''' each independently represent a hydrogen atom or a linear or branched C8-C 40 , preferably C8 to C 30 represents an alkyl-CO- group or an alkenyl-CO- group, with the proviso that at least one of R', R'' and R''' is not a hydrogen atom, and m represents a number in the range of 1 to 30, preferably 1.5 to 10. can be equivalent to:

[0296] Examples of polyoxyethylenated fatty esters that may be mentioned are ethylene oxide adducts with esters of lauric, palmitic, stearic or behenic acid and mixtures thereof, in particular those containing from 9 to 100 oxyethylene units, such as PEG-9 to PEG-50 laurate (CTFA names: PEG-9 laurate to PEG-50 laurate); PEG-9 to PEG-50 palmitate (CTFA names: PEG-9 palmitate to PEG-50 palmitate); PEG-9 to PEG-50 stearate (CTFA names: PEG-9 stearate to PEG-50 stearate); PEG-9 to PEG-50 palmitostearate; PEG-9 to PEG-50 behenate (CTFA names: PEG-9 behenate to PEG-50 behenate); Polyethylene glycol 100 EO monostearate (CTFA name: PEG-100 stearate); and mixtures thereof.

[0297] Preferably, the non-ionic surfactant may be a non-ionic surfactant having an HLB of 8 to 18. HLB is the ratio between the hydrophilic and lipophilic parts of the molecule. The term HLB is well known to those skilled in the art and is described in "The HLB system. A time-saving guide to emulsifier selection" (ICI Americas Inc., 1984).

[0298] The amount of surfactant in the cosmetic composition that can be used for the present invention may be 0.01% by mass or more, preferably 0.05% by mass or more, more preferably 0.1% by mass or more, based on the total mass of the cosmetic composition. The amount of surfactant in the cosmetic composition that can be used for the present invention may be 10% by mass or less, preferably 8% by mass or less, more preferably 5% by mass or less, based on the total mass of the cosmetic composition. The amount of surfactant in the cosmetic composition that can be used for the present invention may be 0.01% by mass to 10% by mass, preferably 0.05% by mass to 8% by mass, more preferably 0.1% by mass to 5% by mass, based on the total mass of the cosmetic composition.

[0299] (Other ingredients) The pH of the cosmetic compositions which may be used for the present invention may be adjusted to the desired value using acidifying or basifying agents commonly used in cosmetic compositions.

[0300] The aqueous phase of the cosmetic composition that can be used for the present invention can be preferably neutral or acidic. Therefore, the aqueous phase of the cosmetic composition preferably has a pH of 1 to 7, more preferably 2 to 6, and even more preferably 3 to 5.

[0301] Among the acidifying agents, mention may be made by way of example of mineral or organic acids, such as hydrochloric acid, ortho-phosphoric acid, sulfuric acid, carboxylic acids, such as acetic acid, tartaric acid, citric acid and lactic acid, and also sulfonic acids.

[0302] Among the basifying agents, examples include ammonium hydroxide, alkali metal carbonates, alkanolamines such as monoethanolamine, diethanolamine and triethanolamine, as well as their derivatives, sodium hydroxide or potassium hydroxide, and also alkoxysilanes of the formula:

[0303] [ka]

[0304] (In the formula, W represents an alkylene, such as propylene, optionally substituted with a hydroxyl group or a C1-C4 alkyl group; R a , R b , R c and R d each independently represents a hydrogen atom, an alkyl group, or a C1-C4 hydroxyalkyl group. These may be exemplified by 1,3-propanediamine and their derivatives.

[0305] The acidifying agent or basifying agent can be used in an amount ranging from 0.001% by mass to 15% by mass, preferably from 0.01% by mass to 10% by mass, and more preferably from 0.1% by mass to 5% by mass, relative to the total mass of the cosmetic composition.

[0306] The cosmetic compositions that can be used for the present invention may also contain various adjuvants conventionally used in cosmetic compositions, such as anionic, nonionic, cationic, and amphoteric or zwitterionic polymers, antioxidants, thickeners, sequestering agents, fragrances, dispersants, conditioning agents, film-forming agents, ceramides, preservatives, and opacifiers.

[0307] (preparation) Cosmetic compositions that can be used for the present invention can be prepared, for example, by mixing oil, water and, if necessary, other ingredients as described above.

[0308] The method and means for mixing the above components are not limited. Any conventional method and means can be used to mix the above components to prepare the cosmetic composition that can be used for the present invention.

[0309] [Beauty method] The cosmetic method according to the present invention comprises: attaching at least one microneedle sheet to at least one application surface of at least one applicator, the microneedle sheet comprising a substrate layer and a plurality of microneedles on the substrate layer, the microneedles comprising at least one water-soluble or water-dispersible polymer, the substrate layer being attached to the application surface of the applicator; applying the applicator onto the keratinous material such that the microneedles contact the keratinous material; Includes.

[0310] The cosmetic method according to the invention may be intended for the cosmetic treatment of keratinous materials such as the skin or lips, preferably the skin, more preferably the skin of the face.

[0311] When the microneedle sheet is used, the base layer of the microneedle sheet is attached to the application surface of an applicator to attach the microneedle sheet to the applicator.

[0312] It is preferred that the microneedle sheet is stored in a container and is removed from the container when the microneedle sheet is to be used.

[0313] It is preferred that the microneedle sheet comprises at least one adhesive layer, which is attached to the application surface of the applicator.

[0314] It is more preferred that the microneedle sheet comprises at least one release layer on the adhesive layer, which release layer is removed from the surface of the adhesive layer when the microneedle sheet is to be used.

[0315] The applicator having the microneedle sheet was then applied onto the keratinous substance by stamping the application surface onto the keratinous substance or by rolling the application surface onto the keratinous substance.

[0316] The microneedles of the microneedle sheet penetrate into the keratin material to provide a cosmetic effect.

[0317] The cosmetic method according to the invention may be used to improve the aesthetic appearance of keratinous materials, for example by reducing the appearance of wrinkles or by delivering any cosmetic active ingredient (if present) in microneedles to the keratinous materials.

[0318] A decrease in the amount of matrix, such as the epidermis, in the skin tends to lead to a decrease in skin thickness and a deterioration in skin elasticity, causing the formation of wrinkles. Microneedles can increase the amount of matrix in the skin, thus increasing the elasticity of the skin and resulting in a reduction in wrinkles on the skin.

[0319] If the microneedle, particularly the distal end portion, is swellable, it can swell in the skin, further increasing the volume of the microneedle, for example with the absorption of water in the skin. Such volume expansion under the skin surface at the wrinkle site can effectively push the wrinkle from inside the skin, making the wrinkle shallower and wider. Thus, the wrinkle can be reduced or made less noticeable.

[0320] Therefore, it is preferable that the cosmetic method according to the present invention includes a step of pressing a microneedle sheet onto a keratinous substance to reliably insert the microneedles of the microneedle sheet into the keratinous substance such as skin.

[0321] In one particular embodiment, the cosmetic method according to the invention may be used to apply semi-permanent or permanent cosmetic treatments to keratinous materials such as the skin. EXAMPLES

[0322] The present invention will be described in more detail by examples. However, these examples should not be construed as limiting the scope of the present invention. The following examples are presented as non-limiting examples in the field of the present invention.

[0323] [Microneedle patch] A microneedle sheet was prepared using sodium hyaluronate with an average molecular weight of 100K Daltons. The microneedle sheet had a plurality of microneedles on a substrate layer. Each microneedle had a cone shape, a length or height of 250 μm, and a diameter of the base of 300 μm. The pitch of the microneedle was 300 μm.

[0324] The microneedle sheet is prepared by standard mold casting method. Sodium hyaluronate, polyvinylpyrrolidone, glycerin, propylene glycol and vitamin C are dissolved in water, and the aqueous solution of these components is poured into the cavity of the mold corresponding to the shape of the microneedle and the base layer. After drying at room temperature to remove water, the microneedle in the cavity is removed from the mold as a microneedle sheet having a plurality of microneedles on the base layer.

[0325] The microneedle sheet was cut so that it had the shape of a patch that was applied onto the applicator.

[0326] The microneedle patch was fixed on one side of a flexible PET (polyethylene terephthalate) film with a pressure-sensitive adhesive. On the other side of the PET film, a pressure-sensitive adhesive containing a vinyl acetate-acrylate copolymer was applied to form a pressure-sensitive adhesive layer. On the free side of the adhesive layer, a release paper was laminated. In this way, a laminated (multi-layered) microneedle patch was prepared.

[0327] [container] A tray made of PET was used as a container. A nonwoven sheet having a thickness of 2 mm was placed in the tray as a porous sheet. The above-mentioned microneedle sheet was placed in the tray so that the microneedles faced the porous sheet in the tray. The microneedles of the microneedle sheet were not broken.

[0328] [Microneedle Assembly] The laminated microneedle patch was attached onto the surface of a cylindrical roller made of stainless steel having a handle made of a plastic material by peeling off the release paper and applying a pressure-sensitive adhesive layer onto the surface of the cylindrical roller (as shown in Figure 3) to prepare a microneedle assembly.

[0329] [evaluation] Human skin samples were prepared by excising human cadaver skin and trimming it to a thickness of 700 μm using an electric dermatome (Integra Life Sciences™, Padgett Instruments, Plainsboro, NJ, USA).

[0330] The roller with the microneedle sheet of the microneedle assembly described above was rolled over the human skin sample 10 times so that the microneedles penetrated into the human skin sample.

[0331] The human skin samples were then immersed in hot liquid paraffin and cooled to prepare paraffin blocks, which were then cut to prepare five cross-sectional slices of human skin.

[0332] For human skin samples on which the microneedle assembly was not rolled, five cross-sectional slices of human skin were also prepared.

[0333] Both sets of cross-sectional slices of human skin were prefixed in Bouin's fixative and stained with Lillie-Mayer's hematoxylin (Muto Chemicals, Japan) and Erosin solution (Fujifilm Wako Pure Chemicals, Inc.) Bright-field images of the HE-stained cross-sections were observed using a digital camera (DFC295, Leica, Germany) at 200x magnification to confirm that the skin had collapsed.

[0334] When comparing cross-sectional views of the skin, it was found that the skin after treatment with rolling on the microneedle assembly, whether or not the microneedle assembly was rolled, showed successful disruption of the stratum corneum of the skin in several areas of the skin, and that the shape of the disruption corresponded to the shape of the microneedles. [Explanation of symbols]

[0335] 1. Microneedle sheet 1-1 Microneedle 1-2 Base material layer 1-3 Base layer 1-4 Adhesive layer 1-5 Peeling layer 1-5-1 Tab 2 Applicator 2-1 Roller 2-1-1 Curved sides 2-2 Handle 2' Applicator 2'-1 Stamp 2'-1-1 flat bottom 2'-2 Handle 3. Keratin Substances 4 containers 5. Porous sheet

Claims

1. At least one microneedle sheet comprising a base layer and a plurality of microneedles on the base layer, the microneedles comprising at least one water-soluble or water-dispersible polymer; at least one applicator having at least one application surface; At least one container A kit comprising: The base layer of the microneedle sheet is attachable to the application surface of the applicator; The container is capable of storing the microneedle sheet, A kit, wherein the container comprises at least one porous article selected from a woven fabric or a nonwoven fabric, and the microneedles of the microneedle sheet can be placed in the article.

2. The kit of claim 1 , wherein the substrate layer of the microneedle sheet is removable from the application surface of the applicator after being attached to the application surface of the applicator.

3. The kit according to claim 1 or 2, wherein the microneedle sheet comprises at least one base layer, the base layer being fixed onto the base material layer.

4. The kit according to claim 1 or 2, wherein the microneedle sheet comprises at least one adhesive layer, the adhesive layer being fixed onto the base layer.

5. The kit of claim 3, wherein the microneedle sheet comprises at least one adhesive layer, the adhesive layer being fixed onto the base layer.

6. The kit of claim 4 or 5, wherein the microneedle sheet comprises at least one release layer, the release layer being placed on the adhesive layer.

7. 7. The kit according to any one of claims 1 to 6, wherein the microneedles have a height of 50 to 1000 microns, preferably 100 to 750 microns, more preferably 150 to 500 microns.

8. 8. The kit of claim 1, wherein the application surface of the applicator is curved.

9. 9. The kit of claim 8, wherein the applicator comprises at least one cylindrical roller having a curved side, the curved side of the cylindrical roller comprising the application surface.

10. 8. The kit of claim 1, wherein the application surface of the applicator is flat.

11. The kit of claim 10, wherein the applicator comprises at least one stamp having at least one planar surface, the planar surface of the stamp comprising the application surface.

12. 12. The kit according to any one of claims 1 to 11, further comprising at least one cosmetic composition.

Images