Method for producing monovalent CCAP product

JP7680745B2Active Publication Date: 2025-05-21KAGOSHIMA UNIV
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Patent Information

Application Number
JP2021553577
Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
Priority Date
2019-10-24
Filing Date
2020-10-23
Publication Date
2025-05-21
Estimated Expiration
2040-10-23

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Abstract

The purpose of the present invention is to provide an Fc-modified antibody which has a long half-life in the blood and is obtained through a CCAP method. More specifically, the purpose of the present invention is to provide an antibody in which IgBP is bound to only one site, on the basis of the findings found by the present inventors.　The present invention provides a target antibody or the like by purifying and producing an Fc-modified antibody or the like using a column that binds to an Fc region of an antibody. Specifically, the present invention provides an antibody in which only one site among two binding sites of Fc is selectively modified by adsorbing an IgBP-binding antibody produced through the CCAP method on a carrier of a IgBP-immobilized column, or by adding, in a state where only one Fc of the antibody is bound to an IgBP-binding column, a peptide reagent for CCAP to the column and performing the reaction of the CCAP method in the column.
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Citation Information

Patent Citations

  • IgG-BINDING PEPTIDE AND METHOD FOR DETECTING AND PURIFYING IgG USING SAME

    WO2013027796A1

  • SPECIFIC MODIFICATION OF ANTIBODY BY IgG-BINDING PEPTIDE

    WO2016186206A1

  • Solid support containing igg-binding peptide, and method for separating igg

    WO2018092867A1

  • IgG-BINDING PEPTIDE, AND SPECIFIC MODIFICATION OF ANTIBODY WITH SAID PEPTIDE

    WO2018230257A1