Liquid medicine administration device

Abstract

To provide a medicinal solution administration device that reduces load on a subject.SOLUTION: A medicinal solution administration device includes one cannula, a sensor and a control unit. The cannula takes body fluid from a subject and injects medicinal solution supplied by a pump into the subject. The sensor measures an object substance contained in the taken body fluid. The control unit controls the pump to adjust an amount of the medicinal solution to be supplied to the cannula on the basis of a measurement result on the object substance by the sensor.SELECTED DRAWING: Figure 5

Description

Technical Field

[0001] Embodiments of the present invention relate to a chemical solution administration device.

Background Art

[0002] Conventionally, an insulin pump that is attached to a subject and continuously administers a chemical solution such as insulin has been known. Also, a technique for controlling the administration amount of insulin by an insulin pump based on the measurement result by a sensor that measures the blood glucose level or the like of a subject has been disclosed.

[0003] In such a conventional technique, a cannula for collecting blood for measuring the blood glucose level or the like and a cannula for injecting insulin into the subject were provided separately. For this reason, a subject using a device based on such a conventional technique has to insert a plurality of cannulas into the body, which may impose a burden on the subject.

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Patent Document 2

Summary of the Invention

Problems to be Solved by the Invention

[0005] The problem to be solved by the present invention is to provide a chemical solution administration device that reduces the burden on a subject.

Means for Solving the Problems

[0006] The chemical solution administration device according to the embodiment includes one cannula, a sensor, and a control unit 、 and is provided with. The cannula collects body fluid from the subject and is supplied from the pump InsulinInject it into the subject. The sensor measures the substance of interest in the collected body fluid. Based on the measurement result of the substance of interest by the sensor, the control unit controls the pump to adjust the amount of Insulin supplied to the cannula. The cannula has a first opening for collecting body fluid from a subject and a second opening for injecting insulin into the subject. The first opening is connected to a first hollow portion through which the body fluid collected from the subject passes. The second opening is connected to a second hollow portion through which the insulin supplied from the pump passes. The sensor is provided in the first hollow portion. When the cannula is placed subcutaneously in the subject 、 The length from the root of the cannula to the first opening is longer than the length from the root of the cannula to the second opening. When the measurement result of the substance of interest by the sensor is equal to or less than the first threshold value, the control unit supplies a chemical solution containing Glucose to the cannula, and transmits the measurement result of the substance of interest by the sensor, the amount of Insulin supplied to the cannula, and the amount of the chemical solution containing Glucose supplied to the cannula to an external device including an electronic medical record device.

Brief Description of the Drawings

[0007]

Figure 1

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MODE FOR CARRYING OUT THE INVENTION

[0008] Hereinafter, embodiments of a medical image processing apparatus and a medical image diagnostic apparatus will be described in detail with reference to the drawings.

[0009] (First Embodiment) FIG. 1 is a diagram showing an example of the appearance of the chemical solution administration device 1 according to the present embodiment. As shown in FIG. 1, the chemical solution administration device 1 includes a main body portion 10, a mounting portion 20, and a cable 30 that connects the main body portion 10 and the mounting portion 20.

[0010] The main body portion 10 includes a display 12 and an input device 11. Further, the main body portion 10 has a function of an insulin pump that supplies insulin to the mounting portion 20 based on the blood glucose level measured by a blood glucose sensor built in the mounting portion 20. Details of the configuration of the main body portion 10 will be described later.

[0011] The mounting portion 20 is a device that is mounted on the skin of a subject. The mounting portion 20 includes a single cannula 22 that collects blood from the subject and injects insulin into the subject. Insulin is supplied to the cannula 22 from a pump of the main body portion 10 described later. Further, the mounting portion 20 incorporates a blood glucose sensor described later.

[0012] Insulin is an example of the chemical solution in this embodiment. Also, blood is an example of the body fluid in this embodiment. The blood glucose sensor is an example of the sensor in this embodiment. Further, an example of the substance to be measured in this embodiment is glucose, and the blood glucose sensor measures the amount of glucose in 1 dL of blood, that is, the glucose concentration (blood glucose level) in the blood.

[0013] The cable 30 is a cable that includes a tube for supplying insulin from the main body 10 to the cannula 22 of the mounting portion 20 and a transmission path for connecting the main body 10 and the blood glucose sensor in the mounting portion 20. The transmission path is assumed to be a transmission path capable of data transmission conforming to a standard such as USB (Universal Serial Bus). The blood glucose sensor transmits the measurement result of the blood glucose level to the main body 10 via the transmission path.

[0014] FIG. 2 is a diagram showing an example of mounting the chemical solution administration device 1 according to this embodiment on the subject P. As shown in FIG. 2, the mounting portion 20 is mounted (fixed) on the epidermis of the subject P.

[0015] Moreover, the chemical solution administration device 1 of this embodiment is a portable chemical solution administration device in which both the main body 10 and the mounting portion 20 can be attached to the body of the subject P or the clothes 900 or the like. As an example, the main body 10 is provided with a gripping portion such as a clip (not shown) on the back surface. The main body 10 can be mounted (fixed) on the subject P by gripping the clothes 900 or the like of the subject P with the clip or the like. Alternatively, the main body 10 may be provided with a belt or the like that can be fixed to the subject P. Further, the main body 10 may be housed in a pocket or the like of the clothes 900 of the subject P.

[0016] FIG. 3 is a diagram showing details of an example of mounting the mounting portion 20 according to this embodiment on the subject P. As shown in FIG. 3, the mounting portion 20 is provided with an adhesive layer 201 on the surface in contact with the subject P, and is fixed to the epidermis of the subject P by bringing the adhesive layer 201 into contact with the epidermis of the subject P.

[0017] When the mounting part 20 is mounted on the epidermis of the subject P, as shown in FIG. 3, the cannula 22 is inserted and retained in the subcutaneous tissue of the subject P. The cannula 22 is a tubular member made of a flexible material. Alternatively, a needle made of metal or the like may be adopted as the cannula 22.

[0018] The blood glucose sensor 21 enclosed in the mounting part 20 measures the glucose concentration in the blood of the subject P collected by the cannula 22, that is, the blood glucose level. For example, the blood glucose sensor 21 applies a voltage to the collected blood and measures the blood glucose level based on the generated current value. The method for measuring the blood glucose level is not limited to this, and known methods can be adopted. The blood glucose sensor 21 transmits the measurement result of the blood glucose level to the main body part 10 via a transmission path enclosed in the cable 30.

[0019] Next, the details of the structure of the cannula 22 in the present embodiment will be described. FIG. 4 is a cross-sectional view showing an example of the cannula 22 according to the present embodiment. In the example shown in FIG. 4, the cannula 22 is retained under the skin of the subject P.

[0020] As shown in FIG. 4, the cannula 22 includes a first opening 221 for collecting blood from the subject P and a second opening 222 for injecting insulin into the subject P.

[0021] The cannula 22 also includes a first hollow part 223 through which the collected blood passes and a second hollow part 224 through which insulin supplied from the main body part 10 passes via a tube in the cable 30. The first opening 221 is connected to the first hollow part 223, and the second opening 222 is connected to the second hollow part 224.

[0022] In this embodiment, the cannula 22 is configured to suck the blood of the subject P from the first opening 221 by, for example, capillary action. The blood sucked from the first opening 221 rises in the first hollow portion 223 by capillary action and reaches the blood glucose sensor 21. Further, a sensor element for measuring the blood glucose level may be provided in the first hollow portion 223. Further, the method of ingesting blood is not limited to this.

[0023] The first opening 221 and the second opening 222 are provided facing different directions. For example, in this embodiment, when the cannula 22 is placed subcutaneously in the subject P, the first opening 221 is provided facing a direction perpendicular to the skin of the subject P. Further, when the cannula 22 is placed subcutaneously in the subject P, the second opening 222 is provided facing a direction parallel to the skin of the subject P.

[0024] Also, the length of the first hollow portion 223 and the length of the second hollow portion 224 are made different. Further, since the first opening 221 is the end of the first hollow portion 223 and the second opening 222 is the end of the second hollow portion 224, the length from the root of the cannula 22 (the end on the mounting portion 20 side) to the first opening 221 and the length from the root of the cannula 22 to the second opening 222 are different.

[0025] In this embodiment, the length of the first hollow portion 223 is made longer than the length of the second hollow portion 224. Therefore, in this embodiment, the first opening 221, which is the end of the first hollow portion 223, is provided closer to the tip of the cannula 22 than the second opening 222, which is the end of the second hollow portion 224. In this case, when the cannula 22 is inserted into the subject P, the first opening 221 collects blood from a position deeper than the position where insulin is injected by the second opening 222.

[0026] Next, the details of the configuration of the chemical solution administration device 1 will be described. FIG. 5 is a block diagram showing an example of the configuration of the chemical solution administration device 1 according to the present embodiment. As shown in FIG. 5, the chemical solution administration device 1 includes a mounting portion 20 and a main body portion 10. The mounting portion 20 includes a blood glucose sensor 21 and a cannula 22. Further, the main body portion 10 includes an input device 11, a display 12, an audio output device 13, an interface (I / F) circuit 14, a processing circuit 15, a storage circuit 16, and a pump 17.

[0027] The input device 11 has buttons, panel switches, etc., receives various operations from the operator, and outputs the received various operations to the processing circuit 15. For example, the input device 11 receives a setting operation from the operator, and an operation to start or end processing, etc.

[0028] The display 12 displays the measurement result of the blood glucose value by the blood glucose sensor 21 or various alerts under the control of the processing circuit 15. The display 12 is an example of the display portion in the present embodiment.

[0029] The audio output device 13 outputs the measurement result of the blood glucose value by the blood glucose sensor 21 or various alerts by sound or voice. The audio output device 13 is an example of the audio output portion in the present embodiment.

[0030] The alerts displayed or output by the display 12 and the audio output device 13 are, as an example, alerts notifying that the measurement result of the blood glucose value by the blood glucose sensor 21 is equal to or less than the first threshold value or equal to or greater than the second threshold value. Details of the alerts will be described later.

[0031] The interface circuit 14 is connected to the processing circuit 15 and controls wireless communication with an external device via a network such as the Internet. The interface circuit 14 is realized by a network card, a network adapter, a NIC (Network Interface Controller), or the like. Further, the interface circuit 14 may communicate with an external device by short-range wireless communication such as WiFi (registered trademark), Bluetooth (registered trademark), or RFID (Radio Frequency Identification). The interface circuit 14 is an example of the communication unit in the present embodiment.

[0032] The pump 17 includes a syringe 173, a motor 172, and an actuator 171. It is assumed that insulin is previously stored in the syringe 173. Further, the syringe 173 is connected to a tube in the cable 30. The syringe 173 includes a plunger (pusher) (not shown).

[0033] When a load is applied to the plunger by the rotation of the motor 172, insulin is discharged from the syringe 173. The insulin discharged from the syringe 173 is supplied to the cannula 22 via the tube in the cable 30 and administered (injected) to the subject P from the second opening 222 through the second hollow portion 224.

[0034] The actuator 171 controls the amount of insulin discharged from the syringe 173 by controlling the rotation of the motor 172 under the control of the processing circuit 15. Note that the configuration of the pump 17 is not limited to this, and known insulin pump technologies can be applied.

[0035] The processing circuit 15 is an example of the control unit in the present embodiment, and controls the pump 17 based on the measurement result of the blood glucose level by the blood glucose level sensor 21 to adjust the amount of insulin supplied to the cannula 22.

[0036] More specifically, the processing circuit 15 includes an acquisition function 151, a determination function 152, a pump control function 153, an output function 154, and a transmission function 155.

[0037] The acquisition function 151 acquires the measurement result of the blood glucose level from the blood glucose sensor 21 at predetermined time intervals. The predetermined time interval is, for example, 5 minutes. The acquisition function 151 stores the acquired measurement result of the blood glucose level in the storage circuit 16 in association with the measurement time. In the present embodiment, the information associating the measurement result of the blood glucose level with the measurement time is referred to as the history of the measurement results of the blood glucose level. Further, the acquisition function 151 sends the acquired measurement result of the blood glucose level to the determination function 152, the output function 154, and the transmission function 155.

[0038] The determination function 152 determines the amount of insulin to be administered to the subject P based on the measurement result of the blood glucose level acquired by the acquisition function 151. Further, the determination function 152 determines whether an alert needs to be output and the content of the alert to be output based on the measurement result of the blood glucose level acquired by the acquisition function 151. The process of this determination executed by the determination function 152 is referred to as the dose determination process.

[0039] More specifically, the determination function 152 determines the insulin dose or the content of the alert based on the result of comparing the measurement result of the blood glucose level with the threshold value of the blood glucose level registered in the insulin administration standard database pre-stored in the storage circuit 16.

[0040] FIG. 6 is a diagram showing an example of the insulin administration standard database 161 according to the present embodiment. As shown in FIG. 6, in the insulin administration standard database 161, the blood glucose level, the amount of insulin to be administered, and the content of the alert to be output are stored in association with each other. Note that the amount of insulin to be administered is represented by the number of units based on "1 unit = 0.01 mL".

[0041] In this embodiment, the blood glucose value is defined by dividing it into six ranges from the first to the sixth range, and the insulin dosage and the content of the alert to be output are associated with each of the ranges from the first to the sixth range. In the example shown in FIG. 6, the first range is "79 mg / dL or less", the second range is "80 mg / dL or more and 159 mg / dL or less", the third range is "160 mg / dL or more and 199 mg / dL or less", the fourth range is "200 mg / dL or more and 249 mg / dL or less", the fifth range is "250 mg / dL or more and 350 mg / dL or less", and the sixth range is "351 mg / dL or more".

[0042] Also, "79 mg / dL or less", which is the upper limit value of the first range, is an example of the first threshold value in this embodiment. Also, "351 mg / dL or more", which is the lower limit value of the sixth range, is an example of the second threshold value in this embodiment.

[0043] For example, when the measured blood glucose value is less than or equal to the first threshold value ("79 mg / dL"), since the subject P may be hypoglycemic, the determination function 152 determines that it outputs an alert of "instruction to ingest 5 g of glucose".

[0044] Also, when the measured blood glucose value is greater than or equal to the second threshold value ("351 mg / dL"), since the subject P is in a hyperglycemic state, the determination function 152 determines that it outputs a "hyperglycemia alert" indicating that the subject P is hyperglycemic. In this embodiment, the alert of "instruction to ingest 5 g of glucose" is the first alert, and the "hyperglycemia alert" is the second alert.

[0045] Also, when the measured blood glucose value falls within the second range, the determination function 152 determines that it does not administer insulin and does not output an alert. Also, when the measured blood glucose value falls within the third to fifth ranges, the determination function 152 determines that it administers the insulin dosage associated with each range to the subject P. The blood glucose value, insulin dosage, and alert content shown in FIG. 6 are examples and are not limited thereto.

[0046] When the determination function 152 determines to administer insulin, it stores the determined insulin dosage in the storage circuit 16 in association with the determination time, that is, the time when insulin was administered. In the present embodiment, the information associating the insulin dosage with the time when insulin is administered is referred to as the history of insulin dosages. Further, the determination function 152 sends the determined insulin dosage to the pump control function 153 and the transmission function 155. Also, when the determination function 152 determines to output an alert, it sends the content of the alert to be output to the output function 154 and the transmission function 155.

[0047] Returning to FIG. 5, the pump control function 153 sends a control signal to the actuator 171 to control the pump 17 so as to discharge the amount of insulin determined by the determination function 152 from the syringe 173.

[0048] The output function 154 controls the display 12 and the voice output device 13. More specifically, the output function 154 causes the display 12 to display the measurement result of the blood glucose level acquired by the acquisition function 151. Also, the output function 154 causes the voice output device 13 to output the measurement result of the blood glucose level acquired by the acquisition function 151 as voice.

[0049] Also, when the determination function 152 determines to output an alert, the output function 154 outputs the alert determined as the output target from the display 12 or the voice output device 13.

[0050] For example, when the determination function 152 determines to output an alert of "Instruction to ingest 5 g of glucose", the output function 154 displays a character message "Please ingest 5 g of glucose" on the display 12. Also, the output function 154 may output the voice "Please ingest 5 g of glucose" from the voice output device 13. When the determination function 152 determines to output a "hyperglycemia alert", the output function 154 may output a warning sound from the voice output device 13.

[0051] Note that the output function 154 may output the measurement result of the blood glucose level or an alert from either the display 12 or the voice output device 13, or may output the measurement result of the blood glucose level or an alert to both the display 12 and the voice output device 13.

[0052] The transmitter function 155 transmits the measurement result of the blood glucose level acquired by the acquisition function 151, the insulin dosage determined by the determination function 152, and various alerts determined to be output by the determination function 152 to an external device via the interface circuit 14. As an example, the alert transmitted by the transmitter function 155 is an alert notifying that the measurement result of the blood glucose level by the blood glucose sensor 21 is equal to or lower than the first threshold value or equal to or higher than the second threshold value.

[0053] FIG. 7 is a diagram showing an example of communication between the chemical solution administration device 1 according to the present embodiment and an external device. A mobile terminal such as a smartphone 4, an electronic medical record device 5, and a recording server device 6 shown in FIG. 7 are examples of external devices that are communication targets of the chemical solution administration device 1. The electronic medical record device 5 is assumed to be, for example, an electronic medical record device of the hospital where the subject P wearing the chemical solution administration device 1 visits. The recording server device 6 is provided with a database that stores the history of the measurement results of the blood glucose level of the subject P and the insulin dosage.

[0054] The transmitter function 155 transmits the measurement result of the blood glucose level, the insulin dosage determined by the determination function 152, and various alerts determined to be output by the determination function 152 to these external devices via the network 7. The network 7 is the Internet or a local area network (LAN), etc.

[0055] For example, when the subject P wearing the liquid medicine administration device 1 is a child, the transmission function 155 may notify the state of the subject P by transmitting various alerts determined to be output by the determination function 152 to the smartphone 4 of the parent of the subject P. Further, when the interface circuit 14 has a short-range wireless communication function such as WiFi (registered trademark), Bluetooth (registered trademark), or RFID, the transmission function 155 may transmit various alerts to the smartphone 4 or the like by short-range wireless communication.

[0056] The external device to be communicated with the liquid medicine administration device 1 is not limited to the example shown in FIG. 7, and the liquid medicine administration device 1 may communicate with various wearable terminals or a PC (Personal Computer) or the like.

[0057] Returning to FIG. 5, the storage circuit 16 stores various information used by the processing circuit 15 in advance. As an example, the storage circuit 16 stores the insulin administration reference database 161. Further, the storage circuit 16 stores the history of the measurement results of the blood glucose level and the history of the administration amount of insulin.

[0058] The storage circuit 16 is realized by, for example, a semiconductor memory element such as a RAM (Random Access Memory) or a flash memory, a hard disk, an optical disk, or the like. The storage circuit 16 is an example of the storage unit in the present embodiment.

[0059] Here, for example, the acquisition function 151, the determination function 152, the pump control function 153, the output function 154, and the transmission function 155, which are components of the processing circuit 15, are stored in the storage circuit 16 in the form of programs executable by a computer. The processing circuit 15 reads each program from the storage circuit 16 and executes the read programs, thereby realizing the functions corresponding to the programs. In other words, the processing circuit 15 in the state of having read each program will have the functions shown in the processing circuit 15 of FIG. 5. In FIG. 5, although the description has been given assuming that each processing function of the acquisition function 151, the determination function 152, the pump control function 153, the output function 154, and the transmission function 155 is realized by a single processing circuit 15, it is also possible to configure the processing circuit 15 by combining a plurality of independent processors, and each processor executes each program to realize each processing function.

[0060] The term "processor" used in the above description means, for example, a CPU (central preprocess unit), a GPU (Graphics Processing Unit), or a circuit such as an application specific integrated circuit (ASIC), a programmable logic device (for example, a simple programmable logic device (SPLD), a complex programmable logic device (CPLD), and a field programmable gate array (FPGA)). Note that instead of storing the program in the storage circuit 16, it may be configured to directly incorporate the program into the circuit of the processor. In this case, the processor realizes its function by reading and executing the program incorporated in the circuit.

[0061] Next, the flow of the process executed by the chemical solution administration device 1 according to the present embodiment will be described. FIG. 8 is a flowchart showing an example of the flow of the process of measuring blood glucose levels and administering insulin executed by the chemical solution administration device 1 according to the present embodiment.

[0062] First, the acquisition function 151 acquires the measurement result of the blood glucose level from the blood glucose level sensor 21 (S1). Then, the acquisition function 151 stores the acquired measurement result of the blood glucose level in the storage circuit 16 in association with the measurement time (S2). Further, the acquisition function 151 sends the acquired measurement result of the blood glucose level to the determination function 152, the output function 154, and the transmission function 155.

[0063] Then, the output function 154 causes the display 12 to display the measurement result of the blood glucose level acquired by the acquisition function 151. Further, the output function 154 causes the voice output device 13 to output the measurement result of the blood glucose level acquired by the acquisition function 151 as voice (S3).

[0064] Then, the transmission function 155 transmits the measurement result of the blood glucose level acquired by the acquisition function 151 to an external device via the interface circuit 14 (S4).

[0065] Next, the determination function 152 executes a dosage determination process (S5). The details of the dosage determination process will be described with reference to FIG. 9.

[0066] FIG. 9 is a flowchart showing an example of the flow of the dosage determination process executed by the chemical solution administration device 1 according to the present embodiment.

[0067] The determination function 152 compares the measurement result of the blood glucose level with the threshold value of the blood glucose level registered in the insulin administration standard database 161 stored in advance in the storage circuit 16. First, the determination function 152 determines whether the blood glucose level of the subject P falls within the range of "0 to 79 (mg / dL)", that is, the first range (S501). If the blood glucose level of the subject P falls within the first range, the blood glucose level of the subject P is equal to or lower than the first threshold value.

[0068] When the determination function 152 determines that the blood glucose level of the subject P falls within the first range (S501 “Yes”), it determines to output a first alert, that is, an alert of “instruction to ingest 5 g of glucose” (S502). In this case, the determination function 152 sends the output of the first alert to the output function 154 and the transmission function 155. Then, the output function 154 outputs the first alert from the display 12 or the voice output device 13. Also, the transmission function 155 transmits the first alert to an external device.

[0069] Also, when the determination function 152 determines that the blood glucose level of the subject P does not fall within the first range (S501 “No”), it determines whether the blood glucose level of the subject P falls within “80 to 159 (mg / dL)”, that is, the second range (S503).

[0070] When the determination function 152 determines that the blood glucose level of the subject P falls within the second range (S503 “Yes”), it determines not to administer insulin (S504). Also, in this case, the determination function 152 determines not to output an alert.

[0071] Also, when the determination function 152 determines that the blood glucose level of the subject P does not fall within the second range (S503 “No”), it determines whether the blood glucose level of the subject P falls within “160 to 199 (mg / dL)”, that is, the third range (S505).

[0072] When the determination function 152 determines that the blood glucose level of the subject P falls within the third range (S505 “Yes”), it determines the insulin dosage to be “2 units” (S506). In this case, the determination function 152 sends the determined insulin dosage to the pump control function 153, the pump control function 153 and the transmission function 155.

[0073] Then, the pump control function 153 controls the pump 17 according to the insulin dosage determined by the determination function 152, and administers insulin corresponding to the determined dosage (in this case, “2 units”) to the subject P (S507).

[0074] Also, the determination function 152 stores the determined insulin dosage in the storage circuit 16 in association with the time when the insulin was administered (S508). Note that the pump control function 153 may store the determined insulin dosage in the storage circuit 16 in association with the time when the insulin was administered.

[0075] Then, the transmitter function 155 transmits the insulin dosage determined by the determination function 152 to an external device (S509).

[0076] Also, when the determination function 152 determines that the blood glucose level of the subject P does not fall within the third range (S505 “No”), it determines whether the blood glucose level of the subject P falls within the range of “200 to 249 (mg / dL)”, that is, the fourth range (S510).

[0077] When the determination function 152 determines that the blood glucose level of the subject P falls within the fourth range (S510 “Yes”), it determines the insulin dosage to be “4 units” (S511). In this case, the determination function 152 sends the determined insulin dosage to the pump control function 153, the pump control function 153, and the transmitter function 155. After the processing of S511, the pump control function 153, the determination function 152, and the transmitter function 155 execute the processing of S507 to S509.

[0078] Also, when the determination function 152 determines that the blood glucose level of the subject P does not fall within the fourth range (S510 “No”), it determines whether the blood glucose level of the subject P falls within the range of “250 to 350 (mg / dL)”, that is, the fifth range (S512).

[0079] When the determination function 152 determines that the blood glucose level of the subject P falls within the fifth range (S512 “Yes”), it determines the insulin dosage to be “6 units” (S513). In this case, the determination function 152 sends the determined insulin dosage to the pump control function 153, the pump control function 153, and the transmitter function 155. After the processing of S513, the pump control function 153, the determination function 152, and the transmitter function 155 execute the processing of S507 to S509.

[0080] Further, when the determination function 152 determines that the blood glucose level of the subject P does not fall within the fifth range (S512 “No”), it determines that the blood glucose level of the subject P is “250 (mg / dL)” or higher, that is, it falls within the sixth range. In this case, since the blood glucose level of the subject P is equal to or higher than the second threshold value, the determination function 152 determines that it outputs the second alert, that is, the “hyperglycemia alert” (S514). In this case, the determination function 152 sends the output of the second alert to the output function 154 and the transmission function 155. Then, the output function 154 outputs the second alert from the display 12 or the voice output device 13. Also, the transmission function 155 transmits the second alert to an external device. Here, the processing of this flowchart ends and returns to FIG. 8.

[0081] In the flowchart of FIG. 8, after the dosage determination process of S5, the acquisition function 151 determines whether to end the process (S6). For example, when the acquisition function 151 receives an end operation for measuring the blood glucose level and administering insulin from the input device 11, it determines to end the process (S6 “Yes”). In this case, the processing of this flowchart ends.

[0082] Further, when the acquisition function 151 does not receive an end operation from the input device 11, it determines not to end the process (S6 “No”). In this case, the acquisition function 151 determines whether a predetermined time has elapsed since the previous blood glucose level measurement (S7). When the acquisition function 151 determines that the predetermined time has not elapsed since the previous blood glucose level measurement (S7 “No”), it returns to the process of S6. Also, when the acquisition function 151 determines that the predetermined time has elapsed since the previous blood glucose level measurement (S7 “Yes”), it returns to the process of S1.

[0083] As described above, according to the chemical solution administration device 1 of the present embodiment, since blood is collected from the subject P and insulin supplied from the pump 17 is injected into the subject P by one cannula 22, the burden on the subject P can be reduced.

[0084] For example, in the case of an apparatus that separately includes a cannula for blood collection for measuring blood glucose level and a cannula for insulin administration, cannulas need to be inserted into two locations on the subject's body. Continuously wearing cannulas at multiple locations on the subject's body may impose a burden on the subject.

[0085] In contrast, in the chemical solution administration device 1 of the present embodiment, since blood is collected from the subject P and insulin is injected into the subject P using a single cannula 22, the number of cannulas 22 to be inserted into the subject P can be made one, and the burden on the subject P can be reduced.

[0086] Also, for example, when a patient (subject) manually measures their blood glucose level and manually sets the insulin dosage based on the result, misreading of the blood glucose measurement result or incorrect setting of the insulin dosage may occur. In this case, there is a possibility that the subject may be administered an incorrect amount of insulin. Especially in type I diabetes, since the subject is often a child, it may not be easy for the subject to measure the blood glucose level and adjust the insulin dosage by themselves.

[0087] In contrast, in the chemical solution administration device 1 of the present embodiment, based on the blood glucose level measurement result by the blood glucose sensor 21, the pump 17 is controlled to adjust the amount of insulin supplied to the cannula 22, so that it is possible to avoid administering an incorrect amount of insulin by the subject manually setting the dosage. Therefore, according to the chemical solution administration device 1 of the present embodiment, the occurrence of incorrect insulin administration can be reduced.

[0088] Also, for example, administering insulin to a person other than a diabetic patient or a person with a normal blood glucose level may cause hypoglycemia. In contrast, in the chemical solution administration device 1 of the present embodiment, based on the blood glucose level measurement result by the blood glucose sensor 21, the amount of insulin is automatically adjusted, so that it is possible to avoid misadministering insulin to a person who does not require insulin administration.

[0089] Furthermore, according to the cannula 22 of the chemical solution administration device 1 of the present embodiment, since the first opening 221 for collecting blood and the second opening 222 for injecting insulin face different directions, blood can be collected from a location different from the location where insulin is administered. Therefore, according to the chemical solution administration device 1 of the present embodiment, even when collecting blood and administering insulin with one cannula 22, the blood glucose level can be measured with high accuracy.

[0090] Furthermore, according to the cannula 22 of the chemical solution administration device 1 of the present embodiment, since the length from the base of the cannula 22 to the first opening 221 and the length from the base of the cannula 22 to the second opening 222 are different, by collecting blood at a position farther from the location where insulin is administered, the blood glucose level can be measured with even higher accuracy.

[0091] Also, according to the chemical solution administration device 1 of the present embodiment, in order to display on the display 12 an alert notifying that the measurement result of the blood glucose level by the blood glucose sensor 21 or the measurement result of blood sugar is below the first threshold or above the second threshold, the subject P can quickly grasp that the subject P has hypoglycemia or hyperglycemia.

[0092] Also, according to the chemical solution administration device 1 of the present embodiment, in order to output an alert notifying that the measurement result of the blood glucose level by the blood glucose sensor 21 or the measurement result of blood sugar is below the first threshold or above the second threshold by sound or voice, the subject P or a person around the subject P can quickly grasp that the subject P has hypoglycemia or hyperglycemia. For example, when the subject P is blind, the subject P can easily grasp the state of the blood glucose level by the chemical solution administration device 1 outputting the measurement result of the blood glucose level and the alert by voice.

[0093] Further, according to the chemical solution administration device 1 of the present embodiment, an alert notifying that the measurement result of the blood glucose level by the blood glucose sensor 21, the administration amount (injection amount) of insulin, or the measurement result of blood glucose is equal to or lower than the first threshold value or equal to or higher than the second threshold value is transmitted to an external device. Therefore, the electronic medical record device 5 or the like can record and manage the state of the blood glucose level of the subject P. Thereby, when examining the subject P, a doctor can make a diagnosis after grasping the control status of the blood glucose level and the like. Further, according to the chemical solution administration device 1 of the present embodiment, by transmitting an alert to the smartphone 4 of the parent of the subject P, when the subject P is a child, the parent or the like of the subject P can quickly grasp the state of the subject P. For example, when the parent or the like of the subject P receives an alert notifying that the measurement result of blood glucose is equal to or lower than the first threshold value on the smartphone 4, the parent or the like can take prompt measures such as having the subject P ingest glucose or the like.

[0094] In addition, in the present embodiment, the processing circuit 15 is taken as an example of the control unit, but the pump control function 153 may be taken as an example of the control unit. Further, in the present embodiment, the interface circuit 14 is taken as an example of the communication unit, but the transmission function 155 may be taken as an example of the communication unit, or the interface circuit 14 and the transmission function 155 may be taken together as an example of the communication unit.

[0095] In addition, in the present embodiment, the transmission function 155 transmits to the external device each time the acquisition function 151 acquires the measurement result of the blood glucose level or each time the determination function 152 determines the administration amount of insulin, but the transmission timing is not limited to this. For example, the transmission function 155 may periodically transmit the history of the measurement results of the blood glucose level and the history of the administration amounts of insulin stored in the storage circuit 16 to the external device.

[0096] In addition, the content of the alert displayed or output by the display 12 or the audio output device 13 of the present embodiment is not limited to the above example. For example, instead of directly displaying or outputting "Please ingest 5 g of glucose", the display 12 or the audio output device 13 may display or output a message instructing to ingest food or drink containing sugar such as "Please eat a cookie" or "Please drink juice". Further, the chemical solution administration device 1 may further include a vibration function for vibrating the main body 10, and when the determination function 152 determines to output an alert, the output function 154 may vibrate the main body 10 according to the content of the alert to be output.

[0097] In addition, the pump 17 of the main body 10 of the chemical solution administration device 1 may adopt a configuration for supplying a chemical solution containing sugar to the cannula 22. When adopting this configuration, when the determination function 152 determines that the measurement result of the blood glucose level is equal to or lower than the first threshold value, the pump control function 153 administers a chemical solution containing sugar to the subject P by supplying a chemical solution containing sugar to the cannula 22.

[0098] In the present embodiment, the cable 30 includes the tube and the transmission line, but the tube and the transmission line may be provided as separate cables. Further, the blood glucose level sensor 21 of the present embodiment may have a function of short-range wireless communication such as WiFi (registered trademark), Bluetooth (registered trademark), or RFID. In this case, the blood glucose level sensor 21 transmits the measured blood glucose level to the main body 10 by short-range wireless communication.

[0099] In the present embodiment, the cannula 22 is in a state of being indwelling in the subject P, but the cannula 22 may be movable. For example, the mounting portion 20 may include a movable portion for inserting and removing the cannula 22, and the movable portion may be inserted into the subject P during blood collection or insulin administration under the control of the processing circuit 15 and removed from the subject P after the completion of collection or administration.

[0100] In addition, in the present embodiment, although the blood glucose sensor 21 is configured to measure the amount of glucose in the blood, the blood glucose sensor 21 may measure the amount of glucose in the interstitial fluid under the skin of the subject P. In this case, the interstitial fluid under the skin is an example of body fluid. Further, the chemical solution administration device 1 may be provided with a sensor that measures a target substance other than blood glucose. For example, the chemical solution administration device 1 may be provided with a sensor that measures HbA1c (glycated hemoglobin A1c) from the blood of the subject P. In addition, in the present embodiment, insulin is taken as an example of the chemical solution, but the chemical solution administration device 1 may be configured to administer a chemical solution such as a diabetes treatment drug other than insulin to the subject P.

[0101] (Second Embodiment) In this second embodiment, in addition to the first embodiment, the chemical solution administration device 1 executes authentication of the subject P before administering insulin.

[0102] FIG. 10 is a block diagram showing an example of the configuration of the chemical solution administration device 1 according to the present embodiment. Similar to the first embodiment, it includes a wearing part 20 and a main body part 10.

[0103] The wearing part 20 of the present embodiment includes a blood glucose sensor 21, a cannula 22, a processing circuit 23, and a storage circuit 24. The blood glucose sensor 21 and the cannula 22 have the same functions as those in the first embodiment.

[0104] The storage circuit 24 stores in advance the authentication information of the subject P. In the present embodiment, the authentication information of the subject P is the genomic information of the subject P. The storage circuit 24 is realized by, for example, a semiconductor memory element such as a RAM or a flash memory, a hard disk, an optical disk, or the like.

[0105] The processing circuit 23 includes an authentication function 231. The authentication function 231 performs genomic analysis on the blood collected by the cannula 22, and authenticates the subject P when the analysis result matches the genomic information of the subject P stored in the memory circuit 24. The processing circuit 23 sends the authentication result of the subject P to the main body unit 10. The authentication function 231 is an example of an authentication unit. The authentication function 231 transmits the authentication result to the main body unit 10 through a transmission path included in the cable 30 or a wireless communication function.

[0106] The authentication function 231, which is a component of the processing circuit 23, is stored in the memory circuit 24 in the form of a program executable by a computer. The processing circuit 23 reads each program from the memory circuit 16 and executes each read program to realize the function corresponding to each program. In other words, the processing circuit 23 in the state of having read each program has the authentication function 231 shown in the processing circuit 23 of FIG. 10. Note that in FIG. 10, the authentication function 231 is described as being realized by a single processing circuit 23, but it is also possible to configure the processing circuit 23 by combining a plurality of independent processors, and each processor executes each program to realize the authentication function 231.

[0107] Similar to the first embodiment, the main body unit 10 includes an input device 11, a display 12, an audio output device 13, an interface circuit 14, a processing circuit 15, a memory circuit 16, and a pump 17. The input device 11, the display 12, the audio output device 13, the interface circuit 14, the memory circuit 16, and the pump 17 have the same functions as those in the first embodiment.

[0108] The processing circuit 15 of the present embodiment includes an acquisition function 1151, a determination function 152, a pump control function 153, an output function 154, and a transmission function 155. The determination function 152, the pump control function 153, the output function 154, and the transmission function 155 have the same functions as those in the first embodiment.

[0109] The acquisition function 1151 of this embodiment has the same functions as those of the first embodiment, and acquires the authentication result of the subject P from the mounting unit 20. When the subject P is authenticated, the acquisition function 1151 acquires the measurement result of the blood glucose level. Further, when the subject P is not authenticated, the acquisition function 1151 does not execute the processes after acquiring the measurement result of the blood glucose level. In this case, the determination process by the determination function 152 and the administration of insulin by the pump control function 153 are not executed.

[0110] FIG. 11 is a flowchart showing an example of the flow of the processes of measuring the blood glucose level and administering insulin executed by the chemical solution administration device 1 according to this embodiment.

[0111] First, the acquisition function 1151 acquires the authentication result of the subject P from the mounting unit 20 (S21). Then, the acquisition function 1151 determines whether the subject P has been authenticated by the authentication function 231 of the mounting unit 20 (S22). When the acquisition function 1151 determines that the subject P has been authenticated by the authentication function 231 of the mounting unit 20 (S22 “Yes”), the process proceeds to the acquisition process of the measurement result of the blood glucose level in S1.

[0112] In this case, the processes of S1 to S7 are executed in the same manner as in the first embodiment. That is, in this embodiment, when the subject P is authenticated, the pump control function 153 controls the pump 17 to supply insulin to the cannula 22.

[0113] Further, when the acquisition function 1151 determines that the subject P has not been authenticated by the authentication function 231 of the mounting unit 20 (S22 “Yes”), the acquisition function 1151 repeats the process of S21. In this case, the processes of S1 to S7 are not executed.

[0114] As described above, according to the chemical solution administration device 1 of this embodiment, when the subject P is authenticated, the pump 17 is controlled to supply insulin to the cannula 22, so that insulin is not administered to a person other than the pre-registered subject P. can be avoided. Therefore, according to the chemical solution administration device 1 of this embodiment, the occurrence of accidental insulin administration can be further reduced.

[0115] In addition, in this embodiment, although the subject P is authenticated based on the genomic analysis result of the blood of the subject P, the authentication method is not limited to this. For example, the chemical solution administration device 1 may authenticate the subject P by communicating with a wearable terminal or a smartphone worn on the subject P. Further, as an authentication method, biometric authentication other than genomic analysis may be adopted.

[0116] Further, instead of the processing circuit 15 of the mounting portion 20, a configuration in which the processing circuit 15 of the main body portion 10 includes the authentication function 231 may be adopted. When adopting such a configuration, the storage circuit 16 of the main body portion 10 shall store the authentication information of the subject P in advance.

[0117] (Modification Example 1) The form of the cannula 22 provided in the chemical solution administration device 1 is not limited to the form described in the first embodiment.

[0118] FIG. 12 is a diagram showing an example of the cannula 22 according to this modification example. As shown in FIG. 12, the cannula 22 may include a plurality of second openings 222a and 222b. In FIG. 12, the number of the second openings 222 is not limited to one or two, and the cannula 22 may further include more second openings 222.

[0119] (Modification Example 2) Further, FIG. 13 is a diagram showing an example of the cannula 22 according to this modification example. The cannula 22 may have a shape in which the tip becomes thinner as shown in FIG. 13. Further, the first opening 221 may be located at the center of the thinner tip of the cannula 22.

[0120] In each of the above-described embodiments, the cannula 22 was assumed to collect blood from the subject P through the first opening 221 and inject insulin into the subject P through the second opening 222. However, the uses of the first opening 221 and the second opening 222 are not limited to this. For example, the cannula 22 may inject insulin into the subject P through the first opening 221 and collect the subcutaneous interstitial fluid of the subject P through the second opening 222.

[0121] According to at least one of the embodiments described above, the burden on the subject P can be reduced.

[0122] Although some embodiments of the present invention have been described, these embodiments are presented as examples and are not intended to limit the scope of the invention. These embodiments can be implemented in various other forms, and various omissions, replacements, and changes can be made without departing from the gist of the invention. These embodiments and their modifications are included in the scope and gist of the invention, as well as in the invention described in the claims and its equivalent scope.

Explanation of Reference Numerals

[0123] 1 Chemical Solution Administration Device 10 Main Body Portion 11 Input Device 12 Display 13 Audio Output Device 14 Interface Circuit 15 Processing Circuit 16 Memory Circuit 17 Pump 20 Mounting Portion 21 Blood Glucose Sensor 22 Cannula 23 Processing Circuit 24 Memory Circuit 30 Cable 151, 1151 Acquisition Function 152 Judgment Function 153 Pump Control Function 154 Output Function 155 Transmission Function 161 Insulin administration reference database 221 First opening 222, 222a, 222b Second opening 223 First hollow part 224 Second hollow part 231 Authentication function P Subject

Claims

1. One cannula for collecting body fluid from a subject and injecting insulin supplied from a pump into the subject, A sensor for measuring a target substance in the collected body fluid, A chemical solution administration device comprising: a control unit that controls the pump based on the measurement result of the target substance by the sensor to adjust the amount of insulin supplied to the cannula, The cannula has a first opening for collecting the body fluid from the subject and a second opening for injecting the insulin into the subject, The first opening is connected to a first hollow portion through which the body fluid collected from the subject passes, The second opening is connected to a second hollow portion through which the insulin supplied from the pump passes, The sensor is provided in the first hollow portion, When the cannula is placed subcutaneously in the subject, the length from the root of the cannula to the first opening is longer than the length from the root of the cannula to the second opening, The control unit, When the measurement result of the target substance by the sensor is equal to or less than a first threshold value, a chemical solution containing glucose is supplied to the cannula, The measurement result of the target substance by the sensor, the amount of insulin supplied to the cannula, and the amount of the chemical solution containing glucose supplied to the cannula are transmitted to an external device including an electronic medical record device. Chemical solution administration device.

2. Further comprising a display unit that displays an alert notifying that the measurement result of the target substance by the sensor, or the measurement result of the target substance by the sensor is equal to or less than a first threshold value or equal to or greater than a second threshold value, The chemical solution administration device according to claim 1.

3. Further comprising an audio output unit that outputs an alert notifying that the measurement result of the target substance by the sensor, or the measurement result of the target substance by the sensor is equal to or less than a first threshold value or equal to or greater than a second threshold value, by sound or voice, The chemical solution administration device according to claim 1 or 2.

4. Further comprising a communication unit that transmits an alert notifying that the measurement result of the target substance by the sensor, the injection amount of insulin, or the measurement result of the target substance by the sensor is equal to or less than a first threshold value or equal to or greater than a second threshold value, to an external device, The chemical solution administration device according to any one of claims 1 to 3.

5. When the control unit authenticates the subject, it controls the pump to supply the insulin to the cannula. The chemical solution administration device according to any one of claims 1 to 4.

6. The body fluid is blood, The substance to be measured is glucose, The sensor measures the concentration of glucose in the collected blood. The chemical solution administration device according to any one of claims 1 to 5.

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