Antiperspirant composition for scalp

Abstract

To provide an antiperspirant composition for scalp that suppresses sweat from scalp, and suppresses a scalp odor while suppressing influence on skin indigenous bacteria on scalp.SOLUTION: An antiperspirant composition for scalp contains (A) at least one selected from the group consisting of phenolic bactericidal component, quaternary ammonium salt, piroctone olamine, glycyrrhetinic acid, and zinc pyrithione, and (B) antiperspirant component.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to an antiperspirant composition for the scalp.

Background Art

[0002] Body odor is mainly caused by the mixture of sebum and sweat being metabolized by skin commensal bacteria to produce fatty acids and the like. Therefore, conventionally, in order to suppress axillary odor and foot odor, an external composition containing a bactericidal component that suppresses the growth of skin commensal bacteria, such as triclosan and benzalkonium chloride, or an external composition containing an antiperspirant component that suppresses the generation of sweat, such as aluminum chloride, is used.

[0003] In recent years, the number of people complaining of discomfort due to head sweat and odor has been increasing, not only in the armpits and feet. It is known that skin commensal bacteria on the scalp are mostly composed of Staphylococcus captis, a bacterium belonging to the genus Staphylococcus, which is different from the skin of other parts. Such a difference in composition is considered to be one of the causes of the difference in the odor of the scalp from the odor generated from the skin of other parts (Non-Patent Document 1).

Prior Art Documents

Non-Patent Documents

[0004]

Non-Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0005] However, at present, the research and development of antiperspirant compositions focusing on such scalp characteristics have not yet progressed sufficiently.

[0006] In view of the above situation, the inventors conducted intensive studies and as a result, focused on the following problems. Skin commensal bacteria maintain the ecological balance on the skin surface and exhibit functions such as barrier functions. Therefore, when an external composition containing a bactericidal component is used on the scalp, depending on the type of the bactericidal component, it may disrupt the ecological balance of the skin commensal bacteria on the scalp, cause scalp odor, or inhibit functions such as barrier functions, leading to the occurrence of skin diseases. In particular, when an external composition containing an antiperspirant component that suppresses the generation of sweat in addition to the bactericidal component is used on the scalp, depending on the type of each component, there may be an additive bactericidal effect higher than the bactericidal effect when the bactericidal component is used alone against the skin commensal bacteria on the scalp, which may greatly disrupt the ecological balance of the skin commensal bacteria on the scalp.

[0007] In addition, when an external composition is used on the scalp, there are concerns about the discomfort of the composition dripping onto the face or the like and the influence on the hairstyle.

[0008] The present invention has been made in view of the above problems, and an object thereof is to provide an antiperspirant composition for the scalp that can suppress the generation of sweat, suppress the odor of the scalp while suppressing the influence on the skin commensal bacteria on the scalp.

[0009] Another object of the present invention is to provide an antiperspirant composition for the scalp that suppresses dripping from the head and has good usability, which has been made in view of the above problems.

Means for Solving the Problems

[0010] In view of the above problems, the inventors conducted intensive studies and as a result, surprisingly, by using an antiperspirant composition for the scalp containing at least one selected from the group consisting of a phenolic bactericidal component, a quaternary ammonium salt, piroctone olamine, glycyrrhetinic acid, and zinc pyrithione and an antiperspirant component, it was found that the generation of sweat can be suppressed, the ecological balance of the skin commensal bacteria on the scalp is easily maintained, and the odor of the scalp can be suppressed. In addition, it was found that it has a remarkable effect of suppressing dripping from the head and having good usability, and the present invention has been completed.

[0011] That is, the present invention relates to the following inventions. [1] An antiperspirant composition for the scalp, containing at least one selected from the group consisting of (A) a phenolic bactericidal component, a quaternary ammonium salt, piroctone olamine, glycyrrhetinic acid, and zinc pyrithione, and (B) an antiperspirant component. [2] The antiperspirant composition for the scalp according to [1], wherein the phenolic bactericidal component is at least one selected from the group consisting of isopropylmethylphenol, triclosan, and trichlorocarbanilide. [3] The antiperspirant composition for the scalp according to [1] or [2], wherein the quaternary ammonium salt is at least one selected from the group consisting of benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride, cetyltrimethylammonium chloride, and cetyltrimethylammonium bromide. [4] The antiperspirant composition for the scalp according to any one of [1] to [3], wherein the component (B) is at least one selected from the group consisting of chlorhydroxyaluminum, aluminum chloride, aluminum zirconium complex salt, allantoin chlorhydroxyaluminum, and zinc paraphenolsulfonate. [5] The antiperspirant composition for the scalp according to any one of [1] to [4], further containing (C) a powder. [6] The antiperspirant composition for the scalp according to any one of [1] to [5], further containing (D) a cooling component. [7] The antiperspirant composition for the scalp according to any one of [1] to [6], which is used for controlling the skin commensal bacteria on the scalp. [8] A method for controlling the skin commensal bacteria on the scalp, using at least one selected from the group consisting of (A) a phenolic bactericidal component, a quaternary ammonium salt, piroctone olamine, glycyrrhetinic acid, and zinc pyrithione, and (B) an antiperspirant component.

Effects of the Invention

[0012] According to the present invention, it is possible to provide an antiperspirant composition for the scalp that can suppress the generation of sweat, easily maintain the balance of skin commensal bacteria on the scalp, and suppress the odor of the scalp.

[0013] Further, according to the present invention, it is possible to provide an antiperspirant composition for the scalp with good usability by suppressing dripping from the head.

Brief Description of the Drawings

[0014]

Figure 1

Figure 2

Modes for Carrying Out the Invention

[0015] Hereinafter, embodiments of the present invention will be described in detail. However, the present invention is not limited to the following embodiments.

[0016] <Antiperspirant Composition for Scalp> The present invention is an antiperspirant composition for the scalp containing (A) at least one selected from the group consisting of a phenolic bactericidal component, a quaternary ammonium salt, piroctone olamine, glycyrrhetinic acid, and zinc pyrithione, and (B) an antiperspirant component, and further contains (C) a powder, (D) a cooling component, or other components as necessary.

[0017] <Component (A)> (A) component is a specific bactericidal component, and is at least one selected from the group consisting of phenolic bactericidal components, quaternary ammonium salts, piroctone olamine, glycyrrhetinic acid, and zinc pyrithione. Examples of the phenolic bactericidal component include isopropylmethylphenol, triclosan, trichlorocarbanilide, and the like. Examples of the quaternary ammonium salt include benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride, cetyltrimethylammonium chloride, cetyltrimethylammonium bromide, and the like. Among them, from the viewpoint of further enhancing the effects of the present invention, preferably, isopropylmethylphenol, piroctone olamine, benzalkonium chloride, cetylpyridinium chloride, cetyltrimethylammonium chloride, cetyltrimethylammonium bromide, glycyrrhetinic acid, and zinc pyrithione. More preferably, isopropylmethylphenol, piroctone olamine, benzalkonium chloride, cetylpyridinium chloride, cetyltrimethylammonium chloride, cetyltrimethylammonium bromide, glycyrrhetinic acid, and zinc pyrithione. Even more preferably, isopropylmethylphenol, benzalkonium chloride, cetyltrimethylammonium bromide, and glycyrrhetinic acid. These may be used alone or in combination of two or more.From the viewpoint of further enhancing the effects of the present invention, preferred combinations include, for example, combinations containing at least isopropylmethylphenol and one or more selected from the group consisting of piroctone olamine, benzalkonium chloride, cetylpyridinium chloride, cetyltrimethylammonium chloride, cetyltrimethylammonium bromide, glycyrrhetinic acid, and zinc pyrithione, or combinations containing at least benzalkonium chloride and one or more selected from the group consisting of piroctone olamine, isopropylmethylphenol, cetylpyridinium chloride, cetyltrimethylammonium chloride, cetyltrimethylammonium bromide, glycyrrhetinic acid, and zinc pyrithione are preferred. Combinations of isopropylmethylphenol and cetyltrimethylammonium bromide, isopropylmethylphenol and glycyrrhetinic acid, isopropylmethylphenol and cetylpyridinium chloride, isopropylmethylphenol and benzalkonium chloride, benzalkonium chloride and cetyltrimethylammonium bromide, benzalkonium chloride and glycyrrhetinic acid, and benzalkonium chloride and cetylpyridinium chloride are more preferred. Combinations of isopropylmethylphenol and cetyltrimethylammonium bromide, isopropylmethylphenol and glycyrrhetinic acid, isopropylmethylphenol and benzalkonium chloride, benzalkonium chloride and cetyltrimethylammonium bromide, benzalkonium chloride and glycyrrhetinic acid, and benzalkonium chloride and cetylpyridinium chloride are even more preferred. A combination of isopropylmethylphenol and benzalkonium chloride is even more preferred.

[0018] The content of component (A) is not particularly limited. However, from the viewpoint of further enhancing the effects of the present invention, it is, for example, 0.001 w / w% or more, preferably 0.005 w / w% or more, and more preferably 0.01 w / w% or more based on the total amount of the composition. Also, the content of component (A) is not particularly limited, but it is, for example, 0.2 w / w% or less, preferably 0.15 w / w% or less, and more preferably 0.1 w / w% or less based on the total amount of the composition.

[0019] When the antiperspirant composition for the scalp containing the component (A) is an aerosol, the content of the component (A) exemplified above is the content with respect to the total amount of the composition excluding the propellant.

[0020] <Component (B)> The component (B) is an antiperspirant component that astringes or occludes sweat glands to suppress the generation of sweat. Examples thereof include aluminum compounds, zirconium compounds, zinc compounds, aluminum-zirconium composite compounds, alum, and the like. Examples of the aluminum compound include aluminum chloride, aluminum sulfate, potassium aluminum sulfate, ammonium aluminum sulfate, aluminum acetate, chlorhydroxyaluminum, allantoin chlorhydroxyaluminum, bromohydroxyaluminum, and the like. Examples of the zirconium compound include zirconium oxide, chlorhydroxyzirconium, and the like. Examples of the zinc compound include zinc paraphenolsulfonate, zinc oxide, and the like. Examples of the aluminum-zirconium composite compound include aluminum zirconium composite salts, and the like. Among them, from the viewpoint of further enhancing the effects of the present invention, preferably, chlorhydroxyaluminum, aluminum zirconium composite salt, zinc paraphenolsulfonate, and alum are used. More preferably, chlorhydroxyaluminum, zinc paraphenolsulfonate, and alum are used. Even more preferably, chlorhydroxyaluminum and zinc paraphenolsulfonate are used. These may be used alone or in combination of two or more.

[0021] The content of the component (B) is not particularly limited, but from the viewpoint of further enhancing the effects of the present invention, for example, it is 0.01 w / w% or more, preferably 0.05 w / w% or more, and more preferably 0.1 w / w% or more with respect to the total amount of the composition. Also, the content of the antiperspirant component (B) is not particularly limited, but for example, it is 30 w / w% or less, preferably 25 w / w% or less, and more preferably 15 w / w% or less with respect to the total amount of the composition.

[0022] When the component (B) is an aluminum compound or a zirconium compound, its content is not particularly limited. However, from the viewpoint of further enhancing the effects of the present invention, it is, for example, 0.1 w / w% or more, preferably 0.5 w / w% or more, and more preferably 1 w / w% or more based on the total amount of the composition. Also, when the component (B) is an aluminum compound or a zirconium compound, its content is not particularly limited, but it is 30 w / w% or less, preferably 25 w / w% or less, and more preferably 15 w / w% or less.

[0023] When the component (B) is a zinc compound, its content is not particularly limited. However, from the viewpoint of further enhancing the effects of the present invention, it is, for example, 0.01 w / w% or more, preferably 0.05 w / w% or more, and more preferably 0.1 w / w% or more based on the total amount of the composition. Also, when the component (B) is a zinc compound, its content is not particularly limited, but it is, for example, 10 w / w% or less, preferably 5 w / w% or less, and more preferably 3 w / w% or less based on the total amount of the composition.

[0024] When the antiperspirant composition for the scalp containing the component (B) is an aerosol, its content is not particularly limited. However, from the viewpoint of further enhancing the effects of the present invention, it is, for example, 0.01 w / w% or more, preferably 0.05 w / w% or more, and more preferably 0.1 w / w% or more based on the total amount of the composition excluding the propellant. Also, the content of the component (B) in the aerosol is not particularly limited, but it is, for example, 5 w / w% or less, preferably 4 w / w% or less, and more preferably 3 w / w% or less based on the total amount of the composition excluding the propellant.

[0025] The ratio of the content of the component (B) to the content of the component (A) is not particularly limited. However, from the viewpoint of further enhancing the effects of the present invention, for example, the content of the component (B) is 0.1 to 30,000 parts by weight, preferably 0.3 to 5,000 parts by weight, and more preferably 1 to 1,500 parts by weight per 1 part by weight of the content of the component (A).

[0026] <(C) powder> From the viewpoint of further enhancing the usability of the antiperspirant composition for the scalp of the present invention, etc., it is preferable to further contain (C) powder. Examples of the (C) powder include organic powders and inorganic powders. Examples of the organic powder include corn starch, rice starch, tapioca starch, potato starch, wheat starch, silicate-modified starch, sodium octenyl succinate starch, aluminum octenyl succinate starch, polyurethane, nylon powder, polystyrene resin, methylsiloxane network polymer, polymethyl methacrylate resin, melamine resin, phenolic resin, fluororesin, cellulose, silicone resin, etc. Examples of the polyurethane include (HDI / trimethylolhexyl lactone) cross-polymer, etc. Examples of the polymethyl methacrylate resin include methyl methacrylate cross-polymer, polymethyl methacrylate, etc. Examples of the silicone resin include (dimethylsilicone / vinyl dimethylsilicone) cross-polymer, (diphenyldimethylsilicone / vinyl diphenyldimethylsilicone / silsesquioxane) cross-polymer, (vinyl dimethylsilicone / methyl silsesquioxane) cross-polymer, etc. Examples of the inorganic powder include sericite, mica, kaolin, red iron oxide, clay, bentonite, silica (anhydrous silicic acid / hydrous silicon dioxide), talc, or those obtained by treating the surface thereof with silicone, etc. Among them, from the viewpoint of further enhancing the effects and usability of the present invention, preferably, corn starch, rice starch, tapioca starch, potato starch, wheat starch, silicate-modified starch, sodium octenyl succinate starch, aluminum octenyl succinate starch, polyurethane, nylon powder, polystyrene resin, methylsiloxane network polymer, polymethyl methacrylate resin, cellulose, silica (anhydrous silicic acid / hydrous silicon dioxide), talc, silicone surface-treated silica, silicone surface-treated talc, silicone resin.More preferably, they are corn starch, sodium octenyl succinate starch, aluminum octenyl succinate starch, polyurethane, nylon powder, methylsiloxane network polymer, polymethyl methacrylate resin, silica (anhydrous silicic acid / hydrous silicon dioxide), talc, silicone surface-treated silica, silicone surface-treated talc, and silicone resin. Even more preferably, they are corn starch, sodium octenyl succinate starch, aluminum octenyl succinate starch, (HDI / trimethylolhexyl lactone) cross-polymer, nylon powder, methylsiloxane network polymer, methyl methacrylate cross-polymer, polymethyl methacrylate, silica (anhydrous silicic acid / hydrous silicon dioxide), talc, (dimethicone / vinyldimethylsilicone) cross-polymer, (diphenyldimethylsilicone / vinyldiphenyldimethylsilicone / silsesquioxane) cross-polymer, (vinyldimethylsilicone / methicone silsesquioxane) cross-polymer, silicone surface-treated silica, and silicone surface-treated talc. Particularly preferably, they are corn starch, silica (anhydrous silicic acid / hydrous silicon dioxide), and talc. These may be used alone or in combination of two or more.

[0027] (C) The shape of the powder is not particularly limited, and examples include spherical, plate-like, granular, and needle-like shapes.

[0028] (C) Examples of commercially available powders include KSP-102, KSP-300, KMP-590, KMP-591, KSG-15 (manufactured by Shin-Etsu Chemical Co., Ltd.), SP-500 (manufactured by Toray Industries, Inc.), Fine Pearl (manufactured by Sumitomo Chemical Co., Ltd.), Tech Polymer SB, Tech Polymer MB (registered trademarks, manufactured by Sekisui Chemical Co., Ltd.), Fine Powder SGP, Fine Powder MP (manufactured by Soken Chemical & Engineering Co., Ltd.), Tospearl 145, Tospearl 2000B (registered trademarks, manufactured by Toshiba Silicone Co., Ltd.), BY29-129, Treffil (registered trademark, manufactured by Toray Dow Corning Silicone Co., Ltd.), Matsumoto Microsphere M (manufactured by Matsumoto Yushi-Seiyaku Co., Ltd.), Japanese Pharmacopoeia Corn Starch ST-C (manufactured by Nippon Starch Chemical Co., Ltd.), Corn Starch (manufactured by Matsutani Chemical Industry Co., Ltd.), Dry Flow PC (manufactured by AkzoNobel), Silica Beads SB-300, SA-SB-300, SA-Talc JA-13R, SA-Talc JA-46R, SA-Talc JA-68R (manufactured by Miyoshi Kasei Co., Ltd.), Aerosil 200 (registered trademark, manufactured by Nippon Aerosil Co., Ltd.), Talc JA-46R, Talc MMR (manufactured by Asada Flour Milling Co., Ltd.), Gun Pearl GM-0610, Gun Pearl GMX-0810, Gun Pearl GPA-550 (registered trademarks, manufactured by Aica Kogyo Co., Ltd.), PLASTIC POWDER D-400, PLASTIC POWDER D-400HP, PLASTIC POWDER D-800 (manufactured by Tosei Pigment Co., Ltd.), and the like.

[0029] (C) The content of the powder is not particularly limited. However, from the viewpoint of further enhancing the effects and usability of the present invention, it is, for example, 0.1 w / w% or more, preferably 0.3 w / w% or more, and more preferably 0.5 w / w% or more with respect to the total amount of the composition. Also, the content of the powder (C) is not particularly limited, but is, for example, 30 w / w% or less, preferably 20 w / w% or less, and more preferably 10 w / w% or less with respect to the total amount of the composition.

[0030] (C) The content of the powder is not particularly limited, but is selected according to the dosage form from the viewpoint of further enhancing the effects and usability of the present invention. In the case of an aerosol, it is, for example, 1 w / w% or more, preferably 3 w / w% or more, more preferably 5 w / w% or more, based on the total amount of the composition excluding the propellant. Also, (C) the content of the powder is not particularly limited, but is, for example, 30 w / w% or less, preferably 25 w / w% or less, more preferably 20 w / w% or less, based on the total amount of the composition excluding the propellant.

[0031] (C) The content of the powder is not particularly limited, but in the case of a liquid agent, emulsion, gel, or cream such as a roll-on type or a mist type, it is, for example, 0.1 w / w% or more, preferably 0.3 w / w% or more, more preferably 0.5 w / w% or more, based on the total amount of the composition. Also, (C) the content of the powder is not particularly limited, but is, for example, 20 w / w% or less, preferably 15 w / w% or less, more preferably 10 w / w% or less, based on the total amount of the composition.

[0032] (C) The ratio of the content of the component (C) to the content of the component (A) is not particularly limited, but from the viewpoint of further enhancing the effects and usability of the present invention, for example, per 1 part by weight of the content of the component (A), the content of the component (C) is 1 to 30,000 parts by weight, preferably 2 to 5,000 parts by weight, more preferably 5 to 2,000 parts by weight.

[0033] (C) The ratio of the content of the component (C) to the content of the component (B) is not particularly limited, but from the viewpoint of further enhancing the effects and usability of the present invention, for example, per 1 part by weight of the content of the component (B), the content of the component (C) is 0.003 to 3,000 parts by weight, preferably 0.01 to 500 parts by weight, more preferably 0.030 to 200 parts by weight.

[0034] (C) The average primary particle diameter of the powder is not particularly limited. However, from the perspective of further enhancing the effects and usability of the present invention, for example, it is 0.1 μm or more, preferably 1 μm or more, and more preferably 5 μm or more. Also, the average primary particle diameter of (C) the powder is not particularly limited. However, for example, it is 30 μm or less, preferably 20 μm or less, and more preferably 15 μm or less. The average primary particle diameter is measured by the laser diffraction scattering method.

[0035] <(D) Cooling component> From the perspective of further enhancing the usability of the antiperspirant composition for the scalp of the present invention, etc., it is preferable to further contain (D) a cooling component. Examples of the (D) cooling component include essential oils such as l-menthol, dl-menthol, l-menthyl glyceryl ether, l-menthyl lactate, methyl salicylate, menthyl 3-hydroxybutyrate, menthoxypropanediol, dl-camphor, chlorobutanol, borneol, geraniol, cineol, limonene, eugenol, eucalyptus oil, bergamot oil, peppermint oil, cool mint oil, spearmint oil, perilla oil, peppermint oil, cinnamon oil, rose oil, turpentine oil, etc. Among them, from the perspective of further enhancing the effects and usability of the present invention, preferably, l-menthol, l-menthyl glyceryl ether, l-menthyl lactate, eucalyptus oil, peppermint oil, chlorobutanol. More preferably, l-menthol, l-menthyl glyceryl ether, eucalyptus oil, peppermint oil. These may be used alone or in combination of two or more.

[0036] (D) The content of the component is not particularly limited. However, from the perspective of further enhancing the effects and usability of the present invention, for example, it is 0.01 w / w% or more, preferably 0.05 w / w% or more, and more preferably 0.1 w / w% or more based on the total amount of the composition. Also, the content of (D) the component is not particularly limited. However, for example, it is 5 w / w% or less, preferably 3 w / w% or less, and more preferably 1 w / w% or less based on the total amount of the composition.

[0037] When the antiperspirant composition for the scalp containing the component (D) is an aerosol, the content of the component (D) exemplified above is the content based on the total amount of the composition excluding the propellant.

[0038] The ratio of the content of the component (D) to the content of the component (A) is not particularly limited. However, from the viewpoint of further enhancing the effects and usability of the present invention, for example, per 1 part by weight of the content of the component (A), the content of the component (D) is 0.05 to 5000 parts by weight, preferably 0.3 to 600 parts by weight, more preferably 1 to 100 parts by weight.

[0039] The ratio of the content of the component (D) to the content of the component (B) is not particularly limited. However, from the viewpoint of further enhancing the effects and usability of the present invention, for example, per 1 part by weight of the content of the component (B), the content of the component (D) is 0.0003 to 500 parts by weight, preferably 0.002 to 60 parts by weight, more preferably 0.006 to 10 parts by weight.

[0040] <Other components> The antiperspirant composition for the scalp of the present invention may contain components other than the above components (A) to (D) (other components) as long as the effects of the present invention are not impaired. For example, a base or carrier, a surfactant, an oil component, a thickener, a preservative, an antioxidant, a preservative, a chelating agent, a pH adjuster, a stabilizer, a solubilizing agent, a buffer, a dispersant, a coloring agent, a moisturizing component, a conditioning agent, a blood circulation promoter, an ultraviolet absorber, an ultraviolet scattering component, an anti-inflammatory agent, vitamins, organic acids, peptides or their derivatives, amino acids or their derivatives, a cleaning component, a cutin softening component, a cell activation component, an anti-aging component, a scalp and hair care component, an anti-glycation component, etc. can be blended. Other components can be used alone or in combination of two or more.

[0041] <Base or carrier> Examples of the base or carrier include hydrocarbons such as liquid paraffin, squalane, gelled hydrocarbons (such as plastibase), ozokerite, α-olefin oligomers, and light liquid paraffin; silicone oils such as methylpolysiloxane, crosslinked methylpolysiloxane, highly polymerized methylpolysiloxane, cyclic silicone, alkyl-modified silicone, crosslinked alkyl-modified silicone, amino-modified silicone, polyether-modified silicone, polyglycerin-modified silicone, crosslinked polyether-modified silicone, crosslinked alkyl polyether-modified silicone, silicone-alkyl chain co-modified polyether-modified silicone, silicone-alkyl chain co-modified polyglycerin-modified silicone, polyether-modified branched silicone, polyglycerin-modified branched silicone, acrylic silicone, phenyl-modified silicone, and silicone resin; polyethylene glycol; dioxane; esters such as isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, cetyl palmitate, isononyl isononanoate, pentaerythrityl tetra(2-ethylhexanoate), and glyceryl tri(caprylate / caprate); lower alcohols such as ethanol and isopropanol; glycol ethers such as diethylene glycol monomethyl ether and diethylene glycol monoethyl ether; polyhydric alcohols such as polyethylene glycol, propylene glycol, 1,3-butylene glycol, glycerin, and isoprene glycol; and aqueous bases such as water, etc.

[0042] <Surfactant> Examples of surfactants include sorbitan fatty acid esters such as sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, diglycerol sorbitan penta-2-ethylhexanoate, and diglycerol sorbitan tetra-2-ethylhexanoate; glycerol fatty acid esters such as lipophilic glyceryl monostearate; propylene glycol fatty acid esters such as propylene glycol monostearate; hydrogenated castor oil derivatives such as polyoxyethylene hydrogenated castor oil 40 (HCO-40), polyoxyethylene hydrogenated castor oil 50 (HCO-50), polyoxyethylene hydrogenated castor oil 60 (HCO-60), and polyoxyethylene hydrogenated castor oil 80 (HCO-80); polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene (20) sorbitan monolaurate (polysorbate 20), polyoxyethylene (80) sorbitan monolaurate, polyoxyethylene (20) sorbitan monostearate (polysorbate 60), polyoxyethylene (20) sorbitan monooleate (polysorbate 80), and polyoxyethylene (20) sorbitan isostearate; polyoxyethylene fatty acid glyceryls such as polyoxyethylene glyceryl monoricinoleate; glycerol alkyl ethers; alkyl glucosides; polyoxyalkylene alkyl ethers such as polyoxyethylene cetyl ether; polyoxyethylene polyoxypropylene alkyl ethers such as polyoxyethylene polyoxypropylene decyltetradecyl ether; nonionic surfactants such as polyoxyethylene lauryl alcohol ether; amines such as stearylamine and oleylamine; polyether-modified silicones such as PEG-11 methyl ether dimethicone, PEG-10 dimethicone, PEG / PPG-19 / 19 dimethicone, and PEG-9 polydimethylsiloxyethyl dimethicone; polyether alkyl co-modified silicones such as lauryl PEG-9 polydimethylsiloxyethyl dimethicone and cetyl dimethicone copolyol; polyglycerol-modified silicones; polyglycerol alkyl co-modified silicones; silicone-based surfactants such as crosslinked silicones;Higher alkyl sulfate salts such as laurate, palmitate, cocooyl glutamate, methyl arainate from coconut oil, acylmethyl taurate, sodium lauryl sulfate; alkyl ether sulfate salts such as sodium POE-lauryl sulfate; N-acyl sarcosinates such as sodium lauroyl sarcosinate; POE-stearyl ether phosphate, potassium cetyl phosphate, cetyl phosphate; sulfosuccinates such as sodium di-2-ethylhexyl sulfosuccinate; alkylbenzene sulfonates; higher fatty acid ester sulfate salts; acylglutamates such as sodium N-lauroylglutamate, disodium N-stearoylglutamate, sodium N-myristoyl-L-glutamate; POE-alkyl ether carboxylic acids; POE-alkyl allyl ether carboxylates; α-olefin sulfonates; anionic surfactants such as higher fatty acid ester sulfonates, lauryldiaminoethyl glycine salt; betaine salts of coconut oil fatty acids; carbobetaine; sulfobetaine; imidazolinium betaine; and amphoteric surfactants such as amide betaine, lecithin, hydrogenated lecithin, saponin, sodium surfactin, bile acids and other surfactants of natural origin, etc. can be mentioned.;

[0043] <Oil component> Examples of the oil component include natural animal and vegetable oils and fats, waxes, hydrocarbon oils, ester oils, silicone oils, higher alcohols, higher fatty acids, etc.

[0044] <Natural animal and vegetable oils and fats> Examples of natural animal and vegetable oils and fats include avocado oil, linseed oil, almond oil, olive oil, cocoa butter, wheat germ oil, sesame oil, rice germ oil, rice bran oil, safflower oil, soybean oil, evening primrose oil, camellia oil, corn oil, rapeseed oil, horse fat, persic oil, palm oil, palm kernel oil, castor oil, sunflower oil, lard, grape seed oil, jojoba oil, macadamia nut oil, kukui nut oil, hazelnut oil, cottonseed oil, beeswax, coconut oil, hydrogenated coconut oil, peanut oil, lanolin, egg yolk oil, rose hip oil, shea butter, etc.

[0045] <Waxes> Examples of waxes include jojoba oil, beeswax, candelilla wax, rice bran wax, cotton wax, carnauba wax, lanolin, and the like.

[0046] <Hydrocarbon oil> Examples of hydrocarbon oils include paraffinic hydrocarbons and olefinic hydrocarbons, and examples thereof include squalane, squalene, ceresin, paraffin, pristane, microcrystalline wax, liquid paraffin, liquid isoparaffin, petrolatum, polybutene, polyethylene powder, gelled hydrocarbon, ozokerite, α-olefin oligomer, light liquid paraffin, light isoliquid paraffin, and the like.

[0047] <Ester oil> As the ester oil, for example, synthetic esters, esters of higher alcohols and higher fatty acids are used. For example, diisopropyl adipate, diisobutyl adipate, 2-hexyldecyl adipate, di-2-heptylundecyl adipate, isostearyl isostearate, trimethylolpropane triisostearate, isononyl isononanoate, isotridecyl isononanoate, cetyl 2-ethylhexanoate, neopentyl glycol di-2-ethylhexanoate, trimethylolpropane tri-2-ethylhexanoate, glyceryl tri-2-ethylhexanoate, pentaerythritol tetra-2-ethylhexanoate, ethyl oleate, cetyl octanoate, oleyl oleate, octyldodecyl oleate, decyl oleate, neopentyl glycol dicaprate, 2-ethylhexyl succinate, isocetyl stearate, butyl stearate, diethyl sebacate, diisopropyl sebacate, di-2-ethylhexyl sebacate, cetyl lactate, tetradecyl lactate, isopropyl myristate, octyldodecyl myristate, cetyl myristate, myristyl myristate, octyl palmitate, 2-ethylhexyl palmitate, 2-hexyldecyl palmitate, isopropyl palmitate, cholesteryl 12-hydroxystearate, phytosteryl oleate, diisostearyl malate, paramethoxycinnamic acid ester, pentaerythritol tetralaurate, bisethoxydiglycol cyclohexane-1,4-dicarboxylate, 2-ethylhexyl succinate, diethoxyethyl succinate, triethyl citrate, decaglyceryl (eicosanedioic acid / tetradecanedioic acid), etc. can be mentioned.

[0048] <Silicone oil> Examples of silicone oils include dimethylpolysiloxane, highly polymerized methylpolysiloxane; phenyl-modified silicones such as methylphenylpolysiloxane; methylhydrogenpolysiloxane; cyclic silicones such as octamethylcyclotetrasiloxane, octamethylcyclopentasiloxane, and decamethylcyclohexasiloxane; crosslinked methylpolysiloxane; methylhydrogenpolysiloxane, methyltrimethicone, dimethiconol, dimethiconol crosspolymer; higher alkoxy-modified silicones such as stearoxysilicone; alkyl-modified silicones such as caprylyl methicone; and higher fatty acid ester-modified silicones.

[0049] <Higher alcohol> Examples of higher alcohols include higher alcohols having 12 to 22 carbon atoms and sterols. Among them, linear saturated alcohols such as lauryl alcohol, myristyl alcohol, cetyl alcohol, cetostearyl alcohol, stearyl alcohol, arachyl alcohol, behenyl alcohol; unsaturated alcohols such as oleyl alcohol, ceryl alcohol; or branched alcohols such as hexyl decanol, isostearyl alcohol, octyldodecanol, decyltetradecanol, lanolin alcohol, isostearyl glyceryl ether, and other phytosterols, cholesterol. Among them, it is preferably used by combining one or more selected from cetyl alcohol, cetostearyl alcohol, stearyl alcohol, behenyl alcohol, oleyl alcohol, isostearyl alcohol, octyldodecanol, lanolin alcohol, isostearyl glyceryl ether, phytosterol, and cholesterol.

[0050] <Higher fatty acid> As the higher fatty acid, for example, a saturated or unsaturated, straight-chain or branched-chain fatty acid having 12 to 22 carbon atoms can be used, such as lauric acid, myristic acid, palmitic acid, stearic acid, margaric acid, arachidonic acid, or behenic acid, etc., which are straight-chain saturated fatty acids; oleic acid, linoleic acid, linolenic acid, arachidonic acid, palmitoleic acid, eicosapentaenoic acid, paxenic acid or docosahexaenoic acid, etc., which are unsaturated fatty acids; or branched-chain fatty acids such as isostearic acid or lanolin fatty acid, or 12-hydroxystearic acid, etc. Among them, preferably, one or more selected from lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, isostearic acid, and lanolin fatty acid are preferably used in combination.

[0051] <Thickener> As the thickener, for example, guar gum, locust bean gum, carrageenan, xanthan gum, carboxymethyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, hydrophobized hydroxypropyl methyl cellulose, pectin, pullulan, agar, sodium alginate, propylene glycol alginate, polyvinyl alcohol, polyvinyl pyrrolidone, carboxyvinyl polymer, acrylic acid methacrylic acid alkyl copolymer, polyethylene glycol, (hydroxyethyl acrylate / sodium acryloyldimethyltaurate) copolymer, (ammonium acryloyldimethyltaurate / vinyl pyrrolidone) copolymer, etc. can be mentioned.

[0052] <Antioxidant> As the antioxidant, for example, dibutylhydroxytoluene (BHT), butylhydroxyanisole, sorbic acid, sodium sulfite, ascorbic acid, erythorbic acid, L-cysteine hydrochloride, tocopherol, tocopherol acetate, etc. can be mentioned.

[0053] <Preservative or Antiseptic> Examples of preservatives or antiseptics include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl p-hydroxybenzoate, isopropyl p-hydroxybenzoate, butyl p-hydroxybenzoate, ethyl p-hydroxybenzoate, propyl p-hydroxybenzoate, benzyl p-hydroxybenzoate, methyl p-hydroxybenzoate, phenoxyethanol, sorbic acid, chlorobutanol, benzyl alcohol, phenethyl alcohol, caprylic hydroxamic acid, methylisothiazolinone, propiolyl butylcarbamate iodide, and the like.

[0054] <Chelating agent> Examples of chelating agents include EDTA disodium salt, EDTA calcium disodium salt, polyphosphoric acid, metaphosphoric acid, and the like.

[0055] <pH adjuster> Examples of pH adjusters include inorganic acids (such as hydrochloric acid, sulfuric acid), organic acids (such as lactic acid, sodium lactate, citric acid, sodium citrate, succinic acid, sodium succinate), inorganic bases (such as potassium hydroxide, sodium hydroxide), organic bases (such as triethanolamine, diisopropanolamine, triisopropanolamine), and the like.

[0056] <Stabilizer> Examples of stabilizers include sodium polyacrylate, dibutylhydroxytoluene, butylhydroxyanisole, and the like.

[0057] <Solubilizing agent> Examples of solubilizing agents include polyhydric alcohols such as polyethylene glycol and propylene glycol, sugar alcohols such as D-mannitol, benzyl benzoate, ethanol, isopropanol, trisaminomethane, cholesterol, triethanolamine, sodium carbonate, sodium citrate, and the like.

[0058] <Buffer> Examples of the buffer include buffer solutions such as phosphates, acetates, carbonates, and citrates.

[0059] <Dispersant> Examples of the dispersant include sodium pyrophosphate, sodium hexametaphosphate, polyvinyl alcohol, polyvinylpyrrolidone, methyl vinyl ether / maleic anhydride cross-linked copolymer, and organic acids.

[0060] <Colorant> Examples of the colorant include inorganic pigments and natural pigments.

[0061] <Humectant> Examples of the humectant include polyhydric alcohols such as glycerin, 1,3-butylene glycol, propylene glycol, polyethylene glycol, and diglycerin; polyhydric alcohol derivatives such as PEG / PPG / polybutylene glycol-8 / 6 / 3 glycerin, PPG-17 buteth-17, and PPG-24 glyceryl ether-24; saccharides such as glycosyl trehalose, trehalose, sorbitol, xylitol, oligosaccharides, and glyceryl glucoside; high molecular compounds such as hyaluronic acids (hyaluronic acid derivatives such as sodium hyaluronate, low molecular weight hyaluronic acid, zinc hyaluronate, acetylated hyaluronic acid, and cationized hyaluronic acid), heparin-like substances, sodium chondroitin sulfate, collagen, elastin, keratin, chitin, and chitosan; amino acids such as glycine, aspartic acid, and arginine and their derivatives; natural moisturizing factors such as sodium lactate, urea, and sodium pyrrolidonecarboxylate; lipids such as ceramide, glucosylceramide, cholesterol, phytosterol, and cholesterol derivative phospholipids; and plant extract extracts such as chamomile extract, witch hazel extract, tea extract, green tea extract, perilla extract, sage extract, seaweed extract, rose extract, peony extract, mugwort extract, aloe extract, saffron extract, and kakkon extract.

[0062] <Conditioning agent> Examples of the conditioning agent include cationized cellulose, cationized starch, cationized fenugreek gum, cationized guar gum, cationized tara gum, cationized locust bean gum, cationized xanthan gum, diallyl quaternary ammonium salt / acrylamide copolymer, polyquaternium, vinylimidazolium trichloride / vinylpyrrolidone copolymer, hydroxyethyl cellulose / dimethyldiallylammonium chloride copolymer, vinylpyrrolidone / quaternized dimethylaminoethyl methacrylate copolymer, polyvinylpyrrolidone / alkylamino acrylate copolymer, polyvinylpyrrolidone / alkylamino acrylate / vinyl caprolactam copolymer, vinylpyrrolidone / methacrylamidopropyl trimethylammonium chloride copolymer, alkyl acrylamide / acrylate / alkylaminoalkyl acrylamide / polyethylene glycol methacrylate copolymer, adipic acid / dimethylaminohydroxypropyl ethylene triamine copolymer, and the like.

[0063] <Blood circulation promoter> Examples of the blood circulation promoter include acetylcholine, ichthyol, caffeine, capsaicin, cantharides tincture, gamma oryzanol, zingiber officinale tincture, gingerol, cephalanthin, ginseng extract, tannic acid, capsicum tincture, terazoline, glucosyl hesperidin, hesperidin, dl-α-tocopherol acetate, tocopherol nicotinate, benzyl nicotinate, angelica root extract, carrot extract, clove extract, chinpi extract, dong quai extract, ginger extract, rhubarb extract, astragalus extract, button mushroom extract, carrot extract, chickweed extract, cinnamon bark extract, and the like.

[0064] <UV absorption component> Examples of the ultraviolet absorbing component include octyl triazone, hexyl diethylaminohydroxybenzoyl benzoate, octyl dimethoxybenzylidene dioxoimidazolidine propionate, 2-ethylhexyl p-methoxycinnamate, t-butyl methoxydibenzoylmethane, phenylbenzimidazole sulfonic acid, octyl methoxycinnamate, ethylhexyl methoxycinnamate, octocrylene, dimethicone diethyl benzalmalonate, and the like.

[0065] <Ultraviolet scattering component> Examples of the ultraviolet scattering component include inorganic compounds such as hydrous silicic acid, zinc silicate, cerium silicate, titanium silicate, zinc oxide, zirconium oxide, cerium oxide, titanium oxide, iron oxide, and anhydrous silicic acid; those obtained by coating these inorganic compounds with inorganic powders such as hydrous silicic acid, aluminum hydroxide, mica, and talc; those obtained by compounding with resin powders such as polyamide, polyethylene, polyester, polystyrene, and nylon; and those treated with silicone oil, aluminum fatty acid salts, and the like.

[0066] <Anti-inflammatory agent> As the anti-inflammatory agent, for example, either a steroid anti-inflammatory agent or a non-steroidal anti-inflammatory agent can be used. For example, allantoin, glycyrrhizic acid or its salts, steroids such as prodnisolone valerate or hydrocortisone, ufenamate, bufexamac, ibuprofen piconol, glycol salicylate, tranexamic acid are exemplified, but not limited thereto. Further, for example, indomethacin, diclofenac, piroxicam, epsilon-aminocaproic acid, berberine, lysozyme, azulene, and their pharmaceutically acceptable salts, plant-derived components (for example, components derived from extracts of comfrey, ourei, dokudami, chlorella, etinashi leaves, yukinoshita, hikiokoshi, ouogon, kawarayomogi, perilla, rhizome of Japanese calamus, sage, hawthorn, clove, neem leaves, boxthorn, peach leaves, cherry leaves, artichoke, seaweed, tea, etc.) are exemplified. Preferably, it is a combination of one or more selected from allantoin, tranexamic acid, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, epsilon-aminocaproic acid, azulene and its derivatives, and more preferably, a combination of one or more selected from allantoin, tranexamic acid, dipotassium glycyrrhizinate, epsilon-aminocaproic acid.

[0067] <Vitamins> Examples of vitamins include vitamin E such as dl-α-tocopherol, dl-α-tocopherol acetate, dl-α-tocopherol succinate, calcium dl-α-tocopherol succinate; vitamin B2 such as riboflavin, flavin mononucleotide, flavin adenine dinucleotide, riboflavin butyrate, riboflavin tetrabutyrate, riboflavin 5'-phosphate sodium, riboflavin tetranicotinate; nicotinic acids such as nicotinic acid, nicotinamide, nicotinic acid dl-α-tocopherol, benzyl nicotinate, methyl nicotinate, β-butoxyethyl nicotinate, 1-(4-methylphenyl)ethyl nicotinate; vitamin C such as ascorbigen-A, stearic acid ascorbate, palmitic acid ascorbate, L-ascorbyl dipalmitate, ascorbyl tetraisopalmitate, sodium 3-palmitoyl ascorbate phosphate, ascorbic acid, sodium ascorbate, dehydroascorbic acid, sodium ascorbate phosphate, magnesium ascorbate phosphate, ascorbic acid glucoside, 2-O-ethyl ascorbic acid, 3-O-ethyl ascorbic acid, glyceryl ascorbic acid, bisglyceryl ascorbic acid, alkyl glyceryl ascorbic acid; vitamin D such as methyl hesperidin, ergocalciferol, cholecalciferol; vitamin K such as phylloquinone, farnoquinone; γ-oryzanol, dibenzoyl thiamine, dibenzoyl thiamine hydrochloride; vitamin B1 such as thiamine and its salts (e.g., dibenzoyl thiamine hydrochloride, thiamine hydrochloride, thiamine nirinate); vitamin B6 such as pyridoxine hydrochloride, pyridoxine acetate, pyridoxal hydrochloride, pyridoxal 5'-phosphate, pyridoxamine hydrochloride; vitamin B12 such as cyanocobalamin, hydroxocobalamin, deoxyadenosylcobalamin; folic acids such as folic acid, pteroylglutamic acid; vitamin A such as retinol, retinol acetate, retinol palmitate, retinol propionate, retinol linoleate and other retinol derivatives, retinal, retinoic acid, tocopheryl retinoate;Provitamin A compounds such as carotene, lycopene, zeaxanthin, cryptoxanthin, and canthaxanthin; pantothenic acid compounds such as pantothenic acid, calcium pantothenate, pantothenyl alcohol (panthenol), D-pantethine, D-pantothenic acid, coenzyme A, and pantothenyl ethyl ether; biotin compounds such as biotin and biocytin; vitamin-like factors such as carnitine, ferulic acid, α-lipoic acid, orotic acid, γ-oryzanol, pyrroloquinoline quinone, glucosyl hesperidin, and ubiquinone, etc. can be mentioned.;

[0068] <Organic acid> Examples of organic acids include gluconic acid, aspartic acid, aminoethylsulfonic acid, citric acid, glutamic acid, succinic acid, oxalic acid, fumaric acid, malonic acid, maleic acid, propionic acid, malic acid, salicylic acid, glycolic acid, phytic acid, tartaric acid, acetic acid, lactic acid, pantothenic acid, alginic acid, ascorbic acid, benzoic acid, adipic acid, glutamic acid, azelaic acid, and salts thereof. Examples of salts include salts of mineral acids such as sulfuric acid, hydrochloric acid, or phosphoric acid, salts of organic acids such as maleic acid or methanesulfonic acid, alkali metal salts such as sodium or potassium, alkaline earth metal salts, ammonium salts, basic amino acid salts, and amine salts such as triethanolamine. Among these, a combination of one or more selected from gluconic acid, citric acid, glutamic acid, succinic acid, malic acid, salicylic acid, glycolic acid, phytic acid, tartaric acid, lactic acid, and salts thereof is preferable, and a combination of one or more selected from gluconic acid, citric acid, glutamic acid, succinic acid, salicylic acid, glycolic acid, phytic acid, tartaric acid, lactic acid, and salts thereof is more preferable.;

[0069] <Peptide or its derivative> Examples of the peptide or its derivative include keratin hydrolyzate, hydrolyzed keratin, collagen, fish-derived collagen, atelocollagen, succinylated atelocollagen, gelatin, elastin, elastin hydrolyzate, collagen hydrolyzate, hydroxypropylammonium chloride hydrolyzed collagen, elastin hydrolyzate, conchiolin hydrolyzate, hydrolyzed conchiolin, silk protein hydrolyzate, hydrolyzed silk, sodium lauroyl hydrolyzed silk, soybean protein hydrolyzate, hydrolyzed soybean protein, wheat protein, wheat protein hydrolyzate, hydrolyzed wheat protein, casein hydrolyzate, acylated peptides (such as palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide), and the like.

[0070] <Amino acid or its derivative> Examples of the amino acid or its derivative include betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, histidine, taurine, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, carnitine, carnosine, creatine, sodium N-stearoyl-L-glutamate, and the like.

[0071] <Washing component> Examples of the cleansing components include alkali metal salts such as potassium laurate, potassium myristate, potassium palmitate or potassium stearate, soaps such as alkanolamide salts or amino acid salts, amino acid-based surfactants such as sodium cocoyl glutamate or sodium cocoyl methyl taurate, ether sulfate ester salts such as sodium lauryl sulfate, ether carboxylate salts such as sodium lauryl ether acetate, sulfosuccinate ester salts such as sodium alkyl sulfosuccinate, fatty acid alkanolamides such as coconut oil fatty acid monoethanolamide or coconut oil fatty acid diethanolamide, monoalkyl phosphate ester salts such as sodium lauryl phosphate or sodium polyoxyethylene lauryl ether phosphate, betaine-type amphoteric surfactants such as coconut oil fatty acid amidopropyl dimethylaminoacetic acid betaine, lauryl dimethylaminoacetic acid betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, lauryl hydroxysulfobetaine and sodium lauroylamide ethyl hydroxyethyl carboxymethyl betaine hydroxypropyl phosphate, and amino acid-type amphoteric surfactants such as sodium lauryl aminopropionate.

[0072] <Keratin softening component> Examples of the keratin softening components include, for example, lanolin, urea, phytic acid, lactic acid, lactate, glycolic acid, salicylic acid, malic acid, citric acid, fruit acid, phytic acid, urea, sulfur, etc. Among them, lactic acid, sodium lactate, glycolic acid, salicylic acid, phytic acid, and citric acid are preferred.

[0073] <Cell activation component> Examples of cell-activating components include amino acids such as γ-aminobutyric acid and ε-aminocaproic acid; vitamins such as retinol, thiamine, riboflavin, pyridoxine hydrochloride, pantothenic acid, and pyrroloquinoline quinones; α-hydroxy acids such as gluconic acid, phytic acid, glycolic acid, and lactic acid; tannins, persimmon tannins, flavonoids, saponins, allantoin, photosensitizer No. 301, panthenol, and components derived from plants (e.g., soybean sprouts, bilberry leaves, etc.).

[0074] <Anti-aging component> Examples of anti-aging components include hydrolyzed soy protein, retinoids (such as retinol, retinoic acid, retinal, etc.), pangamic acid, ursolic acid, turmeric extract, sphingosine derivatives, silicon, silicic acid, N-methyl-L-serine, mevalonolactone, peptides (such as caprooyl tetrapeptide-3, oligopeptide-24, etc.). Among them, hydrolyzed soy protein, retinol, retinol acetate, retinol palmitate, caprooyl tetrapeptide-3, and oligopeptide-24 are preferred.

[0075] <Anti-glycation component> Examples of anti-glycation components include plant extracts such as Buddleja axillaris leaf extract, Japanese apricot fruit extract, and edelweiss extract; evening primrose oil, amla fruit, fruit juice or their extracts; L-arginine, L-lysine, hydrolyzed casein, hydrolyzable tannins, carnosine, etc.

[0076] <Scalp and hair care component> Examples of scalp and hair care ingredients include minoxidil, finasteride, ciproterone chloride, pyridine N-oxide, nicotinic acid derivatives (such as nicotinamide, benzyl nicotinate, tocopherol nicotinate, etc.), γ-oryzanol, capsicum tincture, cepharanthine, vitamin B2s, vitamin B6s, vitamin B12s, pantothenic acid, tocopherol acetate, tocopherol, panthenol, biotin, hydrolyzed soy protein, soy extract, yokukinin, ginkgo extract, carrot extract, centella extract, aloe extract, angelica extract, peucedanum extract, caffeine, chamomile extract, seaweed extract, fucoidan, gentiana extract, polygonatum extract, thixsethninjin tincture, kashu tincture, arnica tincture, female hormones (such as estradiol), etc.

[0077] <ph> The pH of the antiperspirant composition for the scalp of the present invention is not particularly limited as long as the effects of the present invention can be achieved. For example, it is 3 or more, preferably 3.5 or more, more preferably 4 or more, 9 or less, preferably 8 or less, and even more preferably 7.5 or less.

[0078] <Dosage form> The antiperspirant composition for the scalp of the present invention is not particularly limited as long as it is in a known form. For example, it can be formulated by a known method in the form of a liquid, a suspension, an emulsion, a cream, an ointment, a gel, a liniment, a lotion, an aerosol, a powder, a sheet impregnated with the antiperspirant composition for the scalp such as a non-woven fabric, a mist, etc. Among them, a liquid, a suspension, an emulsion, a cream, an emulsion, an ointment, a gel, a lotion, a sheet, an aerosol, a mist are preferred, a liquid, a suspension, an emulsion, a gel, a lotion, a sheet, an aerosol, a mist are more preferred, and a liquid, a suspension, a lotion, a sheet, an aerosol, a mist are even more preferred.

[0079] <Aerosol> The aerosol is one in which the above-mentioned antiperspirant composition for the scalp and a propellant are filled in an aerosol-type spray container. Examples of the propellant used in the aerosol include chlorofluorocarbon gases such as Freon 11, Freon 12, Freon 21, Freon 113, Freon 114, Freon 134a, liquefied petroleum gases (LPG) such as propane, isobutane, and normal butane, and liquefied gases such as dimethyl ether (DME). In addition to these, carbon dioxide gas, nitrogen gas, oxygen gas, etc. may also be used.

[0080] The ratio of the antiperspirant composition for the scalp to the propellant (weight ratio of antiperspirant composition for the scalp / propellant) is not particularly limited, but is usually 1:9 to 9:1, and preferably 2:8 to 8:2.

[0081] <Sheet agent> The sheet agent is obtained by impregnating a sheet base material with the antiperspirant composition for the scalp of the present invention. The sheet base material is not particularly limited as long as it can impregnate and support the antiperspirant composition for the scalp, and woven fabrics, non-woven fabrics, etc. can be arbitrarily used. The fibers constituting the woven fabric and non-woven fabric are not particularly limited, and can be selected from, for example, synthetic fibers, natural fibers, or fibers obtained by mixing and combining these. Specifically, fiber materials such as rayon fibers, cotton, pulp, cellulose, tencel, lyocell, chitin, chitosan, collagen, and alginic acid can be mentioned, but are not limited thereto. Further, it can contain an arbitrary thermoplastic binder. For example, polyolefin-based such as polyethylene and polypropylene; polyester-based such as polyethylene terephthalate, polytrimethylene terephthalate, polybutylene terephthalate, polyethylene naphthalate, and polybutylene naphthalate; polyamide-based such as nylon; and thermoplastic binders composed of various resins such as polyacrylonitrile-based can be mentioned, but are not limited thereto. Further, the thermoplastic binder contained in the non-woven fabric may contain one kind alone or may contain two or more kinds in an arbitrary combination from the above. Further, the basis weight of the sheet base material is not particularly limited, for example, 10~100 g / m 2 , preferably 20~80 g / m 2 , more preferably 30~70 g / m 2 , still more preferably 30~60 g / m 2 is used. Further, the sheet base material may be a sheet base material having a three-dimensional pattern represented by a concavo-convex shape on at least one of the front and back surfaces in an arbitrary regular or irregular shape, or may be a sheet base material having no such three-dimensional pattern. The concavo-convex shape can be processed by an arbitrary method such as mesh processing, embossing, dot processing, or a combination of these processing methods, and a method including mesh processing (for example, a method of performing only mesh processing, a method of combining mesh processing and embossing, a method of combining mesh processing and dot processing, etc.) is preferable. Moreover, the amount of the antiperspirant composition for the scalp to be impregnated into the sheet base material is not particularly limited, and it can usually be impregnated in the range of 0.5 times to 20 times the weight of the sheet base material, preferably 1 time to 10 times. The scalp sheet agent impregnated with the antiperspirant composition for the scalp of the present invention can suppress the generation of sweat from the scalp by wiping the head with the scalp sheet agent, suppress the influence on the skin resident bacteria of the scalp, and suppress the odor of the scalp. In addition, it can wipe off sweat, sebum, etc., and is preferable in that it can be easily refreshed. Among them, the scalp sheet agent impregnated with the antiperspirant composition for the scalp of the present invention is more preferably used, for example, when wiping the periphery of the forehead where sweat is easily wiped, the periphery of the occipital region where odor is likely to be trapped, or the entire head of short hair such as a crew cut or short hair.

[0082] <Container> The antiperspirant composition for the scalp of the present invention can be contained in a container of an appropriately selected shape and material and used according to the purpose of use and application. Specific examples of the container include a spray type, a bottle type, a tube type, a jar type, a spatula type, a dispenser type, a stick type, a pouch bag, and a tea pack. From the viewpoint of ease of application to the scalp, the head part of each container of the antiperspirant composition for the scalp of the present invention can be changed to a sponge-like head, a dropping type head, a pen type head, a roll-on type head, a spatula-like head, a brush-like head, a pin cushion type head, etc. and used. Examples of the material of the container include polyethylene terephthalate, polypropylene, polyethylene (such as HDPE, LDPE, LLDPE), ABS resin, ethylene vinyl alcohol resin, polystyrene, glass, and metal (such as aluminum). Further, these materials can be used as a container material by performing various coating treatments, combining them by mixing these materials, for example, or laminating them, taking into account strength, flexibility, weather resistance, or stability of components. Examples of the coating material include epoxy resin and polyamideimide. Among them, it is preferable to use polyethylene terephthalate, polypropylene, polyethylene (such as HDPE, LDPE, LLDPE), ethylene vinyl alcohol resin, and metal (such as aluminum).

[0083] As the container for the sheet preparation, it is preferably provided in a container with high airtightness. The sheet preparation may be individually packaged as a single-use type, or the wiping sheet preparations for the number of uses may be packaged together so that it can be used multiple times. When packaging as a multiple-use type, it is preferable that the container has a structure that allows the lid to be opened and closed each time it is used and that the opening can be closed when not in use. Here, the lid member that allows the opening to be opened and closed may be a lid member integrally formed with the container, a lid member connected to the container, or a lid member that can be removed from the container. As the lid member that can be removed from the container, for example, a seal-like member provided with an adhesive layer, which can seal the opening with the adhesive layer each time it is used, may be used. Further, when using a seal-like member, the adhesive layer does not necessarily have to be present on the surface of the lid member side, and may be present on the surface of the container side (for example, around the opening). As the materials of the container and the lid member, any materials well-known in the art and having excellent airtightness can be used. Examples include polyolefin resins such as polyethylene and polypropylene; metals such as aluminum; and laminated films laminated with aluminum foil, but are not limited thereto. From the viewpoint of being easy to carry around when going out and being easy to handle, it is preferably a bag-shaped container made of a laminated film laminated with aluminum foil, and is packaged in a container in which the opening can be opened and closed each time it is used with a seal-like lid member.

[0084] <Usage> Specific examples of the uses when it is used as a composition for quasi-drugs or cosmetics include, for example, lotions, milky lotions, gels, creams, beauty essences, cosmetics with a sunblock function, mists, sprays, basic cosmetics for the scalp such as wiping sheets; and cleansing cosmetics such as dry shampoos, shampoos, rinses, and treatments.

[0085] <Viscosity> The viscosity (25°C) of the antiperspirant composition for the scalp of the present invention is not particularly limited as long as the effects of the present invention can be achieved. For example, in the case of a liquid, a suspending agent, a lotion, an aerosol, a mist, or a sheet, the range of 0.01 to 50,000 mPa·s is preferable. Further, the range of 0.1 to 5,000 mPa·s is more preferable, and the range of 1 to 1,000 mPa·s is even more preferable. In the case of an emulsion, a gel, or a cream, the range of 10 to 1,000,000 mPa·s is preferable. Further, the range of 1,000 to 500,000 mPa·s is more preferable, and the range of 10,000 to 100,000 mPa·s is even more preferable. The viscosity (25°C: mPa·s) is the viscosity measured by a single cylindrical rotational viscometer (Brookfield type viscometer) in accordance with the viscosity measurement method described in the general test method of the 17th revised Japanese Pharmacopoeia.

[0086] <Manufacturing method> The manufacturing method of the antiperspirant composition for the scalp of the present invention is not particularly limited, and it can be produced by dissolving, mixing, or dispersing the components (A) to (D) and other components by a conventional method according to the dosage form and form.

[0087] <Use> The present invention is an antiperspirant composition for the scalp, which can be used for controlling the resident skin bacteria of the scalp or suppressing the odor of the scalp. An agent used for controlling the resident skin bacteria of the scalp is beneficial in that it can suppress the disruption of the balance of the resident skin bacteria of the scalp by suppressing the bactericidal effect against Staphylococcus captis, which is a resident skin bacterium of the scalp. Specifically, an agent for controlling the resident skin bacteria of the scalp that combines a specific bactericidal component and an antiperspirant component does not produce a bactericidal effect that exceeds the bactericidal effect of the component with a relatively high bactericidal effect against Staphylococcus captis among the bactericidal component or the antiperspirant component. Therefore, it can suppress the bactericidal effect against the resident skin bacteria of the scalp and is beneficial in that it can suppress the disruption of the balance of the resident skin bacteria of the scalp. The bactericidal effect can be confirmed by a test using the diffusion method (perforated plate method) described later. In addition, an agent that combines a specific bactericidal component and an antiperspirant component and is used for suppressing the odor of the scalp is beneficial in that it can suppress the odor of the scalp by suppressing the metabolism by Staphylococcus captis, which is a resident skin bacterium of the scalp. In addition, an agent that combines a specific bactericidal component and an antiperspirant component and is used for suppressing the odor of the scalp can suppress the odor for a long time and has a persistent inhibitory effect, so it is particularly beneficial in that one can live without worrying about the odor.

[0088] In addition, when the balance of the resident skin bacteria of the scalp is disrupted, the health condition of the scalp deteriorates, hair loss and the like are promoted, and normal hair growth may be inhibited. The present invention can suppress the disruption of the balance of the resident skin bacteria of the scalp by suppressing the bactericidal effect against Staphylococcus captis, which is a resident skin bacterium of the scalp. Therefore, the antiperspirant composition for the scalp of the present invention may be included in hair cosmetics for hair growth, hair nourishment, hair growth promotion, hair growth acceleration, hair loss prevention, improvement of thinning hair, improvement of fine hair, improvement of soft hair, prevention or improvement of dandruff.

[0089] In addition, when sweating on the scalp, stuffiness is caused by hair and hats, leading to itching and discomfort in addition to affecting the balance of the above-mentioned skin commensal bacteria and generating odors. Since the present invention is a sweating control composition for the scalp, for example, in addition to use during periods of high temperature and humidity, it is preferably used in usage scenarios such as when wearing a hat (especially for a long time), before styling hair in the morning, in situations where one is close to people, before and after exercise, and when one wants to change their mood.

[0090] <Method> The present invention includes a method for controlling skin commensal bacteria on the scalp, which uses at least one selected from the group consisting of a phenolic bactericidal component, a quaternary ammonium salt, piroctone olamine, glycyrrhetinic acid, and zinc pyrithione, and a sweating control component. Further, the present invention includes a method for suppressing the odor of the scalp, which uses at least one selected from the group consisting of a phenolic bactericidal component, a quaternary ammonium salt, piroctone olamine, glycyrrhetinic acid, and zinc pyrithione, and a sweating control component. Additionally, the present invention also includes a method for suppressing the dripping of the sweating control composition for the scalp, which uses at least one selected from the group consisting of a phenolic bactericidal component, a quaternary ammonium salt, piroctone olamine, glycyrrhetinic acid, and zinc pyrithione, and a sweating control component.

Example

[0091] The present invention will be described in more detail based on the following examples, but the present invention is not limited to these examples.

[0092] [Test Example 1. Bactericidal Effect Evaluation Test] To evaluate the bactericidal effect of the present invention against skin commensal bacteria on the scalp, Staphylococcus captis was used as the skin commensal bacteria on the scalp, isopropylmethylphenol, benzalkonium chloride, and hinokitiol were used as the bactericidal components, and chlorhydroxyaluminum and zinc paraphenolsulfonate were used as the sweating control components. The following test by the diffusion method (perforated plate method) was conducted.

[0093] A liquid culture of Staphylococcus capitis was inoculated at approximately 10 6 CFU / mL and spread on an MH agar medium (Mueller-Hinton agar medium, petri dish diameter 9 cm). A sterilized punching cutter (manufactured by TOYOBO, biopsy punch 8 mm, stainless steel) was used to make a hole with a diameter of 8 mm in the agar medium. Each test sample shown in Table 1 was injected into the hole until it was full (about 0.1 g), and the culture was incubated at 33°C for 24 hours. After incubation, the diameter (mm) of the inhibition zone was measured, and the average value (n = 3) was calculated. The results are shown in Table 1.

[0094]

Table 1

[0095] From the test results shown in Table 1, as in Example 1-1, it was confirmed that when benzalkonium chloride and zinc parahydroxybenzenesulfonate were used in combination, no additive bactericidal effect was produced against the skin commensal bacteria on the scalp. Specifically, compared with the size of the inhibition zone in Comparative Example 1-4 containing benzalkonium chloride, the bactericidal component, alone, the size of the inhibition zone in Example 1-1 in which benzalkonium chloride, the bactericidal component, and zinc parahydroxybenzenesulfonate, the antiperspirant component, were used in combination did not increase, and it was confirmed that no additive bactericidal effect was produced.

[0096] Also, from the test results shown in Table 1, as in Example 1-2, it was confirmed that when isopropylmethylphenol and chloroaluminum hydroxide were used in combination, no additive bactericidal effect was produced against the skin commensal bacteria on the scalp. Specifically, compared with the size of the inhibition zone in Comparative Example 1-5 containing isopropylmethylphenol, the bactericidal component, alone, the size of the inhibition zone in Example 1-2 in which isopropylmethylphenol, the bactericidal component, and chloroaluminum hydroxide, the antiperspirant component, were used in combination did not increase, and it was confirmed that no additive bactericidal effect was produced.

[0097] Also, from the test results shown in Table 1, it was confirmed that, as in Examples 1-3, when benzalkonium chloride and chloroaluminum hydroxide are used in combination, no additive bactericidal effect on the resident skin bacteria of the scalp occurs. Specifically, compared with the size of the inhibition zone in Comparative Examples 1-4 containing benzalkonium chloride, which is a bactericidal component, alone, the size of the inhibition zone in Examples 1-3 in which benzalkonium chloride, which is a bactericidal component, and chloroaluminum hydroxide, which is an antiperspirant component, are used in combination did not increase, and it was confirmed that no additive bactericidal effect occurred.

[0098] Also, from the test results shown in Table 1, it was confirmed that, as in Examples 1-4, when isopropylmethylphenol and zinc parahydroxybenzenesulfonate are used in combination, no additive bactericidal effect on the resident skin bacteria of the scalp occurs. Specifically, compared with the size of the inhibition zone in Comparative Examples 1-2 containing zinc parahydroxybenzenesulfonate, which is the component that formed the inhibition zone, alone, among isopropylmethylphenol and zinc parahydroxybenzenesulfonate, the size of the inhibition zone in Example 1-4 in which isopropylmethylphenol, which is a bactericidal component, and parahydroxybenzenesulfonic acid, which is an antiperspirant component, are used in combination did not increase, and it was confirmed that no additive bactericidal effect occurred.

[0099] Thus, according to Examples 1-1 to 1-4, no additive bactericidal effect occurs on Staphylococcus capitis, which is a resident skin bacterium of the scalp. Therefore, it is difficult to disrupt the ecological balance of the resident skin bacteria on the scalp and easy to maintain it.

[0100] On the other hand, from the test results shown in Table 1, it was confirmed that, as in Comparative Example 1-7, when hinokitiol and zinc parahydroxybenzenesulfonate are used in combination, an additive bactericidal effect on the resident skin bacteria of the scalp occurs. Specifically, compared with the size of the inhibition zone in Comparative Example 1-3 containing hinokitiol, which is a bactericidal component, alone, the size of the inhibition zone in Comparative Example 1-7 in which hinokitiol, which is a bactericidal component, and zinc parahydroxybenzenesulfonate, which is an antiperspirant component, are used in combination increased, and it was confirmed that an additive bactericidal effect occurred.

[0101] Thus, Comparative Examples 1-7 produce an additive bactericidal effect against Staphylococcus capitis, which is a skin commensal bacterium on the scalp. Therefore, it can be said that the ecological balance of skin commensal bacteria on the scalp is easily disrupted and difficult to maintain.

[0102] As described above, when the bactericidal component and the antiperspirant component are used in combination, depending on the type of each component, an additive bactericidal effect occurs and it is confirmed that the ecological balance of skin commensal bacteria on the scalp is disrupted. On the other hand, according to the present invention, since no additive bactericidal effect occurs, it is confirmed that the ecological balance of skin commensal bacteria on the scalp is difficult to disrupt and easy to maintain.

[0103] [Test Example 2. Evaluation of Inhibitory Effect on Bacterial Metabolism of Sebum] It is known that odor-causing substances are generated when triglycerides in sebum are metabolized by skin commensal bacteria. Therefore, in order to evaluate the inhibitory effect on bacterial metabolism of the present invention against skin commensal bacteria on the scalp, triolein as the main component of sebum, Staphylococcus capitis as the skin commensal bacteria on the scalp, isopropylmethylphenol, benzalkonium chloride, and hinokitiol as bactericidal components, and chlorhydroxyaluminum and zinc paraphenolsulfonate as antiperspirant components were prepared, and the following tests were conducted.

[0104] To a tryptone soy agar medium (petri dish diameter 9 cm), 0.005 cc / cm of triolein 2 and a bacterial solution adjusted to a bacterial count of 6.5×10 of Staphylococcus capitis 5 / cm 2 were applied, and further 0.3 cc of each test sample shown in Table 2 below was applied per petri dish. After culturing at 35°C for 3 days, extraction was performed with ether, and oleic acid in each extract was quantified using gas chromatograph (GC-MS) analysis under the following measurement conditions. Since the amount of oleic acid, which causes scalp odor, increases when triolein is decomposed, the less the amount of oleic acid, the more the scalp odor is suppressed.

[0105] <GC-MS Measurement Conditions> · Model: Gas Chromatograph-Mass Spectrometer (GC-MS) manufactured by Agilent Technologies GC: 7890B MS: 5977A Column: HPINNOWAX, 30 m, 0.25 mm I.D., 0.25 μm, manufactured by GL Sciences Carrier gas: He <GC Conditions> Temperature: 80°C ⇒ Temperature increase (20°C / min) ⇒ 260°C (6 minutes) Flow rate: 1 mL / min Injection volume: 1 μL Inlet: 260°C Split ratio: 10:1 Ionization method: Electron Ionization (EI)

[0106] Note: As a blank, except for not applying the bacterial solution and each test sample, the same steps as above were performed to quantify oleic acid. Also, as a control, except for not applying each test sample, the same steps as above were performed to quantify oleic acid.

[0107] The value obtained by subtracting the quantification value of the blank from the quantification values of each example, each comparative example, and the control was taken as the true oleic acid amount of each example, each comparative example, and the control. Taking the true oleic acid amount of the control as 100, the oleic acid amounts of each example and each comparative example were determined, and the results are shown in Figure 1.

[0108]

Table 2

[0109] From the test results shown in Fig. 1, it was confirmed that the combined use of benzalkonium chloride and zinc parahydroxybenzenesulfonate in Example 2-1 can suppress the decomposition amount of triolein by the skin commensal bacteria on the scalp. Specifically, compared with the amount of oleic acid in the control, the amount of oleic acid in Example 2-1 in which benzalkonium chloride and zinc parahydroxybenzenesulfonate were used in combination was significantly decreased, so it was confirmed that the decomposition amount of triolein by the skin commensal bacteria on the scalp can be suppressed.

[0110] From the results of the bacterial metabolism inhibition evaluation test of Example 2-1 and the results of the bactericidal effect evaluation test of Example 1-1, the combined use of benzalkonium chloride and zinc parahydroxybenzenesulfonate can suppress the generation of sweat by the action of the antiperspirant component, while not producing an additive bactericidal effect. Therefore, it can suppress the decomposition amount of triolein by the skin commensal bacteria on the scalp without disrupting the ecological balance of the skin commensal bacteria on the scalp, and thus can suppress the odor of the scalp, and it was confirmed that it is extremely useful as an antiperspirant composition for the scalp.

[0111] On the other hand, from the test results shown in Fig. 1, it was confirmed that the combined use of hinokitiol and chlorohydroxyaluminum in Comparative Example 2-6 and the combined use of hinokitiol and zinc parahydroxybenzenesulfonate in Comparative Example 2-7 cannot suppress the decomposition amount of triolein by the skin commensal bacteria on the scalp. Specifically, compared with the amount of oleic acid in the control, the amount of oleic acid in Comparative Example 2-6 in which hinokitiol and chlorohydroxyaluminum were used in combination and Comparative Example 2-7 in which hinokitiol and zinc parahydroxybenzenesulfonate were used in combination did not decrease, and it was confirmed that the decomposition amount of triolein by the skin commensal bacteria on the scalp cannot be suppressed.

[0112] From the results of the bacterial metabolism inhibition evaluation test of Comparative Example 2-6 in Fig. 1 and the results of the bactericidal effect evaluation test of Comparative Example 1-6 in Table 1, it was confirmed that the combined use of hinokitiol and chlorohydroxyaluminum does not produce an additive bactericidal effect, but cannot suppress the decomposition amount of triolein by the scalp commensal bacteria, so it cannot suppress the odor of the scalp.

[0113] From the results of the bacterial metabolism inhibition evaluation test of Comparative Examples 2-7 in FIG. 1 and the results of the bactericidal effect evaluation test of Comparative Examples 1-7 in Table 1, when hinokitiol and zinc parahydroxybenzenesulfonate are used in combination, an additive bactericidal effect is produced, which easily disrupts the ecological balance of the skin resident bacteria on the scalp, and moreover, since the decomposition amount of triolein by the skin resident bacteria on the scalp cannot be suppressed, it was confirmed that the odor of the scalp cannot be suppressed.

[0114] As described above, when a bactericidal component and an antiperspirant component are used in combination, depending on the type of each component, it was confirmed that an additive bactericidal effect is produced, the ecological balance of the skin resident bacteria on the scalp is disrupted, and the odor of the scalp cannot be suppressed. On the other hand, when a specific bactericidal component and an antiperspirant component are used in combination as in the present invention, since the generation of sweat is suppressed and an additive bactericidal effect is not produced, it is difficult to disrupt the ecological balance of the skin resident bacteria on the scalp and it is easy to maintain this balance, and moreover, since the decomposition amount of triolein by the skin resident bacteria on the scalp can be suppressed, it was confirmed that the odor of the scalp can be suppressed.

[0115] [Test Example 3. Evaluation of Inhibition of Bacterial Metabolism of Sebum] Combining bactericidal components of different types is important, for example, from the viewpoint of exerting a bactericidal effect suitable for various skin conditions such as the amount of sebum present on the skin. Therefore, in order to evaluate the bacterial metabolism inhibition effect in the present invention when a plurality of bactericidal components are included, as shown in Table 3, a test sample containing a bactericidal component and an antiperspirant component, and a test sample further blended with a bactericidal component of a different type were each prepared with respect to the test sample, and the following tests were conducted.

[0116] To a tryptone agar medium (petri dish diameter 9 cm), 0.005 cc / cm of triolein 2 and Staphylococcus capitis with a bacterial count of 6.5×10 5 / cm 2 The adjusted bacterial solution was applied, and 0.3 cc of each test sample shown in Table 3 was applied per Petri dish. After culturing at 35 °C for 3 days, it was extracted with ether, and oleic acid in each extract was quantified using gas chromatograph (GC-MS) analysis. The measurement conditions of the gas chromatograph (GC-MS) were the same as those in Test Example 2.

[0117] Taking the amount of oleic acid in Comparative Example 3-1 quantified as 100 (reference), the amounts of oleic acid in Example 3-1 and Example 3-2 were determined, and the results are shown in Figure 2.

[0118]

Table 3

[0119] From the test results shown in Figure 2, according to the combination of benzalkonium chloride, isopropylmethylphenol, and zinc para - phenolsulfonate in Example 3-2, it was confirmed that the decomposition amount of triolein by skin resident bacteria on the scalp can be suppressed to the same extent as the combination of benzalkonium chloride and zinc para - phenolsulfonate in Example 3-1. Specifically, for example, since there is a bactericidal component such as hinokitiol that cannot suppress bacterial metabolism but rather promotes it (see Comparative Example 2-3 in Test Example 2), depending on the type of bactericidal components combined, the bacterial metabolism inhibitory effect may be impaired. However, as in Example 3-2, a combination containing benzalkonium chloride as a bactericidal component, zinc para - phenolsulfonate as an antiperspirant component, and further containing isopropylmethylphenol as a bactericidal component was confirmed to have an undiminished bacterial metabolism inhibitory effect.

[0120] As described above, according to the combination of benzalkonium chloride, isopropylmethylphenol, and zinc para - phenolsulfonate in Example 3-2, it was confirmed that the decomposition amount of triolein by skin resident bacteria on the scalp can be suppressed, so that the scalp odor can be suppressed. At the same time, by using different types of bactericidal components, it was confirmed that a bactericidal effect suitable for various skin conditions, such as the amount of sebum present on the skin, can be exerted.

[0121] [Test Example 4. Evaluation Test of Usability of Formulations] In order to evaluate the usability of the present invention, the following tests were conducted. A commercially available artificial leather (manufactured by Idemitsu Techno Fibre Co., Ltd., Supplierle PBZ13001) measuring 2 cm × 15 cm, to which 15 μL of jojoba oil (manufactured by Nikko Chemicals Co., Ltd., NIKKOL Jojoba Oil S) was applied, was installed almost vertically. 5 μL of each formulation shown in Table 4 was dropped, and the length (cm) of the drip after 15 seconds was measured. The results are shown in Table 4. Note that the compounding amounts in the following Examples and Comparative Examples are w / w%.

[0122] [Table 4]

[0123] From the test results shown in Table 4, it was confirmed that, as in Examples 4-1 and 4-2, formulations containing benzalkonium chloride and chloroaluminum hydroxide or zinc parahydroxybenzenesulfonate can unexpectedly improve the dripping condition. Specifically, the drip lengths in Example 4-1 in which benzalkonium chloride and chloroaluminum hydroxide were used in combination and Example 4-2 in which benzalkonium chloride and zinc parahydroxybenzenesulfonate were used in combination were decreased compared to Comparative Examples 4-1, 4-2, and 4-3 which were each a single component, so it was confirmed that there was no discomfort and the usability on the scalp was good.

[0124] Also, from the test results shown in Table 4, it was confirmed that, as in Examples 4-3 and 4-4, formulations containing isopropylmethylphenol and chloroaluminum hydroxide or zinc parahydroxybenzenesulfonate can unexpectedly improve the dripping condition. Specifically, the drip lengths in Example 4-3 in which isopropylmethylphenol and chloroaluminum hydroxide were used in combination and Example 4-4 in which isopropylmethylphenol and zinc parahydroxybenzenesulfonate were used in combination were decreased compared to Comparative Examples 4-1, 4-2, and 4-4 which were each a single component, so it was confirmed that there was no discomfort and the usability on the scalp was good.

[0125] Furthermore, from the test results shown in Table 4, it was confirmed that, as in Examples 4-5 and 4-6, preparations containing glycyrrhetinic acid and chlorohydroxyaluminum or zinc paraphenolsulfonate can unexpectedly improve sagging. Specifically, the sagging length in Example 4-5, which uses glycyrrhetinic acid and chlorohydroxyaluminum in combination, and in Example 4-6, which uses glycyrrhetinic acid and zinc paraphenolsulfonate in combination, is reduced compared to Comparative Examples 4-1, 4-2, and 4-5, which use each component alone, so there is no discomfort and it is confirmed that the usability on the scalp is good.

[0126] [Test Example 5. Evaluation of the usability and usability of the formulation] In order to evaluate the usability and usability of the present invention, the same usability evaluation test as in Test Example 4 above (evaluation of the length of drooping of the formulation) and the following usability evaluation test were carried out for each formulation example shown in Table 5. For the evaluation of usability, each formulation example was filled into a general trigger-type spray bottle (spray volume 0.3mL to 0.5mL) that can spray mist, and five expert panelists sprayed one push of each onto the scalp from a distance of 5cm from the scalp, and rated on a 10-point scale from 1 to 10 for three items: "non-sticky scalp," "refreshing scalp," and "quick-drying sensation." A higher number indicates a higher evaluation. The average score of the evaluation results of the five panelists was calculated and evaluated according to the following criteria. The results are shown in Table 5. The blend amounts in the following examples and comparative examples are w / w %. [Evaluation Criteria] ◎: 7 points or more ○: 5 points or more and less than 7 points △: 3.5 points or more and less than 5 points ×: Less than 3.5 points

[0127] [Table 5]

[0128] From the test results shown in Table 5, as in Example 5-1, a preparation containing benzalkonium chloride, chloroaluminum hydroxide, further containing corn starch which is a powder, and l-menthol which is a cooling component, unexpectedly not only improved the dripping condition, but also was confirmed to obtain an especially excellent feeling in use. Further, as in Example 5-2, a preparation containing zinc paraphenolsulfonate, isopropylmethylphenol, further containing talc which is a powder, and l-menthol which is a cooling component, unexpectedly not only improved the dripping condition, but also was confirmed to obtain an excellent feeling in use. On the other hand, Comparative Example 5-1 which is different only in that it does not contain chloroaluminum hydroxide compared to Example 5-1 was confirmed to be inferior in both the dripping length and the feeling in use compared to Example 5-1.

[0129] As described above, according to the present invention in which a specific bactericidal component and an antiperspirant component are used in combination, it is possible to suppress the generation of sweat, and it is difficult to disrupt the ecological balance of the skin resident bacteria on the scalp, and the odor of the scalp can be suppressed. That is, in addition to the sweat odor of the scalp, it is possible to comprehensively suppress the odor of the scalp, such as the oxidation odor generated by the mixture of sweat and sebum, and the fatty acid odor discharged by the decomposition of sebum or the metabolism by skin resident bacteria. In addition to this, it was also confirmed that there is a remarkable effect that the usability on the scalp is good. Further, in the present invention in which a specific bactericidal component and an antiperspirant component are used in combination, it was confirmed that if a powder or a cooling component is further blended, there is a remarkable effect that the feeling in use is good.

[0130] Hereinafter, formulation examples of the antiperspirant composition for scalp of the present invention will be shown. In addition, the blending amounts in the following formulation examples are w / w%.

[0131] (Formulation Example 1) (Liquid agent) (Mist type) Isopropylmethylphenol 0.1% Chloroaluminum hydroxide 10% Ethanol 70% Hydroxyethylcellulose 0.2% l-Menthol 0.3% Green tea extract 0.1% Fragrance (soap type), appropriate amount Water, the balance

[0132] (Formulation Prescription Example 2) (Liquid) (Roll-on type) Benzalkonium chloride 0.1% Zinc paraphenolsulfonate 3% Ethanol 50% Hydroxypropyl methylcellulose 0.2% l-Menthol 0.2% l-Menthyl glyceryl ether 0.1% Hamamelis extract 0.1% Rose hip extract 0.1% Aluminum octenyl succinate starch 5% Fragrance (sweet floral type), appropriate amount Water, the balance

[0133] (Formulation Prescription Example 3) (Liquid) (Drop type) Glycyrrhetinic acid 0.1% Chlorohydroxyaluminum 15% Ethanol 50% Xanthan gum 0.2% Persimmon tannin 0.1% Green tea extract 0.1% Assembly extract 0.1% Paraben 0.2% Water, the balance

[0134] (Formulation Prescription Example 4) (Liquid) (Brush type) Benzalkonium chloride 0.05% Isopropyl methylphenol 0.1% Zinc paraphenolsulfonate 1% Ethanol 20% Carrageenan 0.3% 1,3-Butylene glycol 10% Cationized cellulose 1% Polyoxyethylene hydrogenated castor oil 0.5% Tocopheryl Acetate 0.1% Artemisia Princeps Extract 0.1% Water Balance

[0135] (Formulation Prescription Example 5) (Emulsion) (Bottle Type) Triclosan 0.1% Benzethonium Chloride 0.05% Aluminum Chloride 5% Diethyl Sebacate 2% Liquid Paraffin 2% Sorbitan Monostearate 0.5% Polysorbate 60 0.7% Ethanol 10% Carboxyvinyl Polymer 0.2% Phenoxyethanol 0.3% Nylon Powder 1% Aloe Extract 0.1% Triethanolamine Q.S. Water Balance

[0136] (Formulation Prescription Example 6) (Aerosol, (Liquid: Propellant = 1:1)) Benzalkonium Chloride 0.03% Isopropyl Methylphenol 0.03% Chlorhydroxyaluminum 10% Ethanol 30% l-Menthol 0.1% l-Menthyl Glyceryl Ether 0.05% Hamamelis Extract 0.1% Rosaceae Extract 0.1% Talc 5% Corn Starch 3% Fragrance (Fresh Citrus Type) Q.S. Water Balance DME 50%

[0137] (Formulation Prescription Example 7) (Aerosol, (Liquid: Propellant = 6:4)) Benzethonium Chloride 0.03% Trichlorocarbanilide 0.03% Zinc paraphenolsulfonate 2% Ethanol 40% l-Menthol 0.1% l-Menthyl glyceryl ether 0.05% Hamamelis extract 0.1% Chamomile extract 0.1% Nylon powder 5% Octenyl succinic anhydride modified starch aluminum salt 3% Fragrance (citrus herb type) appropriate amount Water remaining amount LPG 40%

[0138] (Formulation prescription example 8) (Dry shampoo) (Aerosol, (Liquid: Propellant = 6:4)) Isopropylmethylphenol 0.01% Zinc paraphenolsulfonate 0.5% Ethanol 30% l-Menthol 0.1% l-Menthyl glyceryl ether 0.05% Hamamelis extract 0.1% Chamomile extract 0.1% Silica 5% Mica 3% Fragrance (verbena type) appropriate amount Water remaining amount LPG 40%

[0139] (Formulation prescription example 9) (Dry shampoo) (Mist type) Benzalkonium chloride 0.01% Isopropylmethylphenol 0.01% Chlorohydroxyaluminum 1% Ethanol 30% l-Menthol 0.3% Tea extract 0.1% Ginseng extract 0.1% Peony extract 0.1% Talc 5% Mica 3% Geranium-based fragrance, appropriate amount Water, the remaining amount

[0140] (Formulation Prescription Example 10) (Wiping Sheet) (Sheet base material: Cotton, rayon, polyester synthetic fiber) Benzalkonium chloride 0.01% Chlorhydroxyaluminum 5% Ethanol 30% Polyoxyethylene polyoxypropylene decyltetradecyl ether 1% l-Menthol 0.2% Paeonia extract 0.1% Safflower extract 0.1% Comfrey extract 0.1% Citrus-based fragrance, appropriate amount Water, the remaining amount

[0141] (Formulation Prescription Example 11) (Emulsion-impregnated Wiping Sheet) (Sheet base material: Cellulose) Isopropylmethylphenol 0.05% Zinc paraphenolsulfonate 3% Sugar squalane 2% Tri(caprylic / capric acid) glyceryl 1% Bis(ethoxydiglycol) cyclohexane-1,4-dicarboxylate 0.3% Methylpolysiloxane 0.5% Xanthan gum 0.1% Polyoxyethylene hydrogenated castor oil 0.5% Hydrophobic glyceryl monostearate 0.3% l-Menthol 0.5% Seaweed extract 0.1% Artichoke extract 0.1% Safflower extract 0.1% Tea dry distillate 0.1% Assembly extract 0.01% Carrot extract 0.01% 0.01% Prunus persica bark extract The balance is water

[0142] (Formulation Example 12) (Liquid) (Mist type) 0.05% Isopropylmethylphenol 3% Zinc paraphenolsulfonate 50% Ethanol Polyoxyethylene polyoxypropylene decyltetradecyl ether 1% (Eicosanedioic acid / Tetradecanedioic acid) decaglyceryl 0.5% 0.2% l-Menthy glyceryl ether 0.5% l-Menthol 0.1% Lysozyme hydrochloride 0.1% Tea pyroligneous liquor 0.01% Seaweed extract 0.01% Saxifraga stolonifera extract 0.01% Tea extract 0.01% Witch hazel extract 0.01% Paeonia lactiflora extract 0.05% Fragrance (Botanical floral type) The balance is water< / ph>

Claims

1. A scalp antiperspirant composition containing (A) a phenolic bactericidal component and (B) an antiperspirant component, wherein the (A) phenolic bactericidal component is isopropylmethylphenol, and the (B) antiperspirant component is at least one selected from the group consisting of chlorhydroxyaluminum, aluminum chloride, aluminum zirconium complex salt, allantoin chlorhydroxyaluminum, and zinc paraphenolsulfonate (however, excluding an emulsified deodorant composition containing polyether-modified silicone, (dimethylsilicone / vinyl dimethylsilicone) copolymer, 2-ethylhexyl palmitate, an antiperspirant, a bactericide, and water).

2. The scalp antiperspirant composition according to claim 1, further containing (C) a powder.

3. The scalp antiperspirant composition according to claim 1 or 2, further containing (D) a refreshing component.

4. The scalp antiperspirant composition according to any one of claims 1 to 3, which is used for controlling the skin resident bacteria on the scalp.

5. A method for controlling the skin resident bacteria on the scalp, using a composition containing (A) a phenolic bactericidal component and (B) an antiperspirant component, wherein the (A) phenolic bactericidal component is isopropylmethylphenol, and the (B) antiperspirant component is at least one selected from the group consisting of chlorhydroxyaluminum, aluminum chloride, aluminum zirconium complex salt, allantoin chlorhydroxyaluminum, and zinc paraphenolsulfonate (however, excluding an emulsified deodorant composition containing polyether-modified silicone, (dimethylsilicone / vinyl dimethylsilicone) copolymer, 2-ethylhexyl palmitate, an antiperspirant, a bactericide, and water).

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