Double-chamber internal circulation sealed chemical liquid transfer device and chemical liquid transfer system

Abstract

The present invention discloses a double-chamber internal circulation sealed liquid medicine transfer device and transfer system, the liquid medicine transfer device includes a double-chamber syringe 10, a dispensing needle assembly 20, and a needle seal assembly 30. The product structure of the present invention is exquisitely designed and easy to assemble, can realize completely sealed preparation and transfer of medicine, can automatically or manually adjust and balance the air pressure in the medicine container during use, can minimize the risk of drug leakage, has excellent sealing effect, low cost, and is convenient to use.

Description

Technical Field

[0001] The present invention relates to the field of drug preparation and transfer devices, and more specifically to a closed-type drug solution transfer device and a drug solution transfer system with double-chamber internal circulation.

Background Art

[0002] Hazardous drugs represented by chemotherapeutic drugs pose a great hazard to the health of medical staff who are engaged in the preparation and transfer of such drugs for a long time. For example, cancer, organ damage, DNA damage, reproductive problems, miscarriage and teratogenicity. According to conventional data, the cancer incidence rate of pharmacists, nurses and other personnel who have been in contact with hazardous drugs for a long time is 3 to 10 times higher than that of the general population, and the risks of infertility or miscarriage are 2 to 5 times higher. Therefore, some medical institutions have built various facilities such as purification rooms and biological safety cabinets to reduce the risk of drug leakage. Although the investment is large, the actual popularization and application effect is not good. In the domestic medical treatment stage, the demand for closed-type drug solution transfer devices is large, but the options are few. The products are required to have not only good airtightness, but also low cost and convenient use. BD Company in the United States has recently launched a closed-type structure and transfer system, but it is difficult to popularize because of its complex structure, high cost and complicated operation. Moreover, this system can only reduce the leakage risk by 50% to 80%. The applicant of the present invention has previously sold two types of drug solution transfer devices (CN111346008A and CN111346009A) equipped with air bags for air pressure balance, which have low cost, convenient use and relatively good internal circulation airtightness effect. However, some problems have also been found in the popularization and application. For example, the air bag structure is easily damaged / detached, and the channel connecting the air bag is easily invaded by the drug solution and blocked. Therefore, there is still a certain leakage risk.

Summary of the Invention

Problems to be Solved by the Invention

[0003] In view of the deficiencies of the prior art and the needs of actual applications, the object of the present invention is mainly to provide a double-chamber internal circulation sealed chemical liquid transfer device and a transfer system. The structure is exquisitely designed, easy to assemble, and can realize the preparation and transfer of completely sealed drugs. During the use process, the air pressure in the drug container can be automatically or manually adjusted to balance, and the risk of drug leakage can be reduced to the greatest extent. It has the advantages of very excellent sealing effect, low cost, and high convenience in use.

Means for Solving the Problems

[0004] To achieve the above object, as a first aspect of the present invention, there is provided a double-chamber internal circulation sealed chemical liquid transfer device including a double-chamber syringe, a dispensing needle assembly, and a needle seal assembly. The double-chamber syringe is composed of a first syringe barrel, a first piston rod that can slide back and forth along the inner cavity in the first syringe barrel, a second syringe barrel, and a second piston rod that can slide back and forth along the inner cavity in the second syringe barrel. Here, the first syringe barrel and the second syringe barrel are arranged side by side, in the same direction, and are fixedly installed in a manner that their front ends are flush. A first joint is installed on the front end face of the first syringe barrel, and a second joint is installed on the front end face of the second syringe barrel. The dispensing needle assembly includes a dispensing needle and a needle hub. The dispensing needle is fixedly connected to the needle hub in a manner that its rear end is embedded in the front end of the needle hub. Here, at the rear end of the needle hub, a first connection hole matching the first joint and a second connection hole matching the second joint are installed, and inside the needle hub, a first channel and a second channel that are respectively communicated with the first connection hole and the second connection hole and are independent of each other are installed. The dispensing needle has a two-layer columnar structure and has an inner column channel and a side ring channel. Here, the inner column channel is communicated with the first channel, and the side ring channel is communicated with the second channel. By embedding the first joint and the second joint into the first connection hole and the second connection hole respectively, the dispensing needle assembly and the double-chamber syringe achieve a fixed and sealed connection. The needle seal assembly includes a sheath coaxially installed with the dispensing needle, a sealing member, and an elastic member. Here, The sheath is a hollow cylindrical structure with openings at the front and rear, and is sleeved on the front end of the needle hub so as to be axially movable. The sealing member is made of an elastic material and is fixedly installed inside the front-end cylinder of the sheath. A hole tube for the dispensing needle to pass through is provided on the central axis of the sealing member. The inner diameter of the hole tube is smaller than the outer diameter of the dispensing needle. The elastic member is installed between the sealing member and the needle hub. Depending on the needle hub, the elastic member provides axial elastic support to the front-end sealing member. In the non-pressurized state, the elastic member extends axially. The sheath shields the dispensing needle inside the sheath. Due to the elastic action of the elastic material, the sealing member tightly wraps the front end of the dispensing needle, and seals the front channel openings of the inner column channel and the side ring channel inside. In the pressurized state, the elastic member is axially compressed, and the front end of the dispensing needle including the front channel openings of the inner column channel and the side ring channel can pass through the hole tube of the sealing member and exit from the sheath, which is characterized by this.

[0005] In the present invention, unless otherwise specified, the front end refers to the end pointed by the tip of the dispensing needle, and the rear end refers to the other end opposite to it.

[0006] In the closed - type chemical solution transfer device of the present invention, the double - chamber syringe is composed of a first syringe barrel, a first piston rod that can slide back and forth along the inner cavity in the first syringe barrel, a second syringe barrel, and a second piston rod that can slide back and forth along the inner cavity in the second syringe barrel. The first syringe barrel and the second syringe barrel are arranged side by side, in the same direction, and are fixedly installed in such a way that their front ends are flush. The present invention does not particularly limit the specifications of the first syringe barrel and the second syringe barrel, and they may be the same or different. However, from the perspective of production and the convenience of actual operation, as a preferred embodiment, the first syringe barrel and the second syringe barrel have the same size specifications. Preferably, the first syringe barrel and the second syringe barrel are made of a transparent material, and a scale for indicating the volume is installed on the surface of the barrel body.

[0007] The function of the joint on the front end face of the syringe barrel is mainly embodied in two aspects. One is that it serves as an insertion - type fixed connection component between the double - chamber syringe and the dispensing needle assembly, and the other is that it serves as an entrance and exit for the chemical solution or gas to enter and exit the syringe barrel. In view of the size limitation of the needle hub, preferably, the first joint and the second joint are installed in a manner as close as possible.

[0008] As a preferred embodiment, the outer side walls of the first joint and the second joint are tapered surfaces, and at least one annular boss is installed on the tapered surface. Correspondingly, the shapes of the first connection hole and the second connection hole installed at the rear end of the needle hub respectively match the tapered surfaces of the corresponding joints, and annular grooves corresponding to the annular bosses are installed on the hole walls. By the insertion - type fixation of the joint and the connection hole, a fixed and sealed connection between the dispensing needle assembly and the double - chamber syringe can be easily realized.

[0009] In the closed - type chemical solution transfer device of the present invention, the dispensing needle assembly includes a dispensing needle and a needle hub, and the dispensing needle is fixedly connected to the needle hub in such a way that its rear end is embedded in the front end of the needle hub.

[0010] The dispensing needle has a two-layer columnar structure and has an inner column channel and a side ring channel. As a preferred embodiment, the dispensing needle may be composed of an inner needle tube and an outer needle tube. The inner needle tube is bored inside the outer needle tube, and both ends extend outside the outer needle tube. At this time, the inner column channel is formed by the inner cavity of the inner needle tube, and the side ring channel is formed by the cavity between the outer needle tube and the inner needle tube.

[0011] The inner needle tube and the outer needle tube may be independent of each other, integrally formed, or fixedly connected to each other. If the latter type is selected, preferably the front end of the outer needle tube is hermetically and fixedly connected to the front end side wall of the inner needle tube. More preferably, the front end of the inner needle tube is installed at an oblique opening, or the front end of the inner needle tube is the tip, and a side opening is installed, and a side opening is installed on the front end side wall of the outer needle tube. Designing the opening in this way is not only advantageous for the dispensing needle to pierce the drug container, but also can reduce the interference between both the inner column channel and the side ring channel, and when the side ring channel is used as the drug solution channel, the side opening installed at the rear fits better with the operating habit of reversing the liquid medicine bottle when medical staff prepares the medicine, which is advantageous for more fully sucking the drug solution (especially the drug solution at the bolt port), and avoiding the waste of the drug or the increase in the operation risk caused by secondary operations.

[0012] The needle hub is a carrier for installing the dispensing needle and the needle seal assembly. As described above, at the rear end of the needle hub, a first connection hole matching the first joint and a second connection hole matching the second joint are installed, and inside the needle hub, a first channel and a second channel that communicate with the first connection hole and the second connection hole respectively and are independent of each other are installed. The inner column channel of the dispensing needle communicates with the first channel, and the side ring channel communicates with the second channel.

[0013] In a preferred embodiment, an attachment groove is provided at the front end of the needle hub, and a needle-passing base (corresponding to digging out a lump from the front end of the needle hub) with an outer shape structure matching the attachment groove is mounted in the attachment groove. The front-end openings of the first channel and the second channel are both located at the bottom of the attachment groove, and the position of the front-end opening of the first channel is coaxial with the dispensing needle. Inside the needle-passing base, a through-hole tube penetrating in the front-rear direction is installed at a position corresponding to the axis of the dispensing needle, which is composed of a needle-passing hole located at the front part and a fixing hole located at the rear part. The needle-passing hole is trumpet-shaped, and the inner diameter gradually decreases from the front to the rear until the fixing hole. The inner diameter of the fixing hole matches the outer diameter of the outer needle tube. A communication groove is installed on the rear end face of the needle-passing base, and both ends communicate with the second channel and the fixing hole respectively. The rear end of the inner needle tube of the dispensing needle is fixed in the first channel in an embedded manner through the needle-passing base, and the rear end of the outer needle tube is fixed in the fixing hole of the needle-passing base in an embedded manner.

[0014] More preferably, in the above embodiment, the first channel in the needle hub is installed in a manner coaxial with the dispensing needle, and the second channel is installed parallel to one side of the first channel.

[0015] More preferably, the cross-section of the needle-passing base is not circular and is maintained so as not to change along the axial direction. The purpose of such a design is to enable the needle-passing base to be mounted in the attachment groove of the needle hub only at a fixed angle, facilitating the accurate butting of the communication groove at the bottom of the needle-passing base and the second channel.

[0016] After fully understanding the structure of the needle hub and the dispensing needle, those skilled in the art can easily determine how to assemble the dispensing needle assembly. For example, when the dispensing needle is composed of an inner needle tube and an outer needle tube that are independent of each other, first take out the needle-passing base, embed the rear end of the inner needle tube into the first channel, then fix the outer needle tube to the needle-passing base, and further set the integrated outer needle tube and needle-passing base outside the inner needle tube and insert them into the mounting groove. Or, when the inner needle tube and the outer needle tube are integrally formed and fixed and connected to each other, first take out the needle-passing base, fix the dispensing needle to the needle-passing base, ensure that the rear end of the outer needle tube is embedded in the fixing hole of the needle-passing base and penetrates through the rear end of the inner needle tube and exits from the needle-passing base. Then, insert the needle-passing base into the mounting groove and ensure that the rear end of the exposed inner needle tube is completely embedded in the first channel.

[0017] After the dispensing needle assembly and the double-chamber syringe are fixed and hermetically connected, the inner column channel, the first channel, the first connection hole, and the first syringe communicate with each other in sequence from front to back to form a sealed passage I, and the side ring channel, the second channel, the second connection hole, and the second syringe communicate with each other in sequence from front to back to form a sealed passage II. The sealed passages I and II are independent of each other. In the process of preparing and transferring the chemical solution, one of the two passages is used for transmitting the chemical solution, and the other can transmit gas and play a role in balancing the air pressure.

[0018] In the present invention, the needle seal assembly includes a sheath installed coaxially with the dispensing needle, a sealing member, and an elastic member. By installing the needle seal assembly, not only can the function of preventing needle penetration be exerted, but also it can be ensured that the entire process of preparing and transferring the chemical solution is completely sealed, and the risk of the chemical solution leaking from the front-end channel port can be avoided. Assemblies with similar structures and functions have already been reported in the applicant's previous patents, such as CN111346008A and CN111346009A. However, their manufacturing processes are relatively complex, and it is necessary to use components with relatively complex structures, and it is not possible to use a simple combination of structural components. Therefore, specific equipment needs to be used during batch production, or the requirements for the accuracy of the equipment are relatively high.

[0019] In order to simplify the manufacturing process, make the assembly easy, and further reduce the batch production cost, the applicant optimized the structure of the needle seal assembly. As a preferred embodiment of the present invention, the needle seal assembly includes a sheath installed coaxially, a sealing member, an elastic member, and an inner sleeve. Here, The front end portion of the sheath forms a composite cylindrical structure composed of a first cylindrical segment with a smaller radial size and an inner diameter that is relatively small, and a second cylindrical segment with a relatively large inner diameter. The sealing member is designed to have a structure with an inverted T-shaped cross-section. The diameter of the front portion corresponds to the inner diameter of the first cylindrical segment, and the diameter of the rear portion corresponds to the inner diameter of the second cylindrical segment. Thereby, the sealing member can completely fill the inner cavity of the first cylindrical segment and at the same time can fill at least a part of the inner cavity of the second cylindrical segment. The inner diameter of the inner sleeve corresponds to the outer diameter of the needle hub, the outer diameter of the inner sleeve corresponds to the inner diameter of the second cylindrical segment of the sheath, its front end face is sealed, and a through hole for the dispensing needle to pass through is installed at the center of the end face. The inner sleeve is fixedly connected inside the second cylindrical segment of the sheath, and the front end face abuts against the rear end face of the sealing member. The elastic member is installed inside the inner sleeve, and both ends thereof are respectively in contact with the inner surface of the front end of the inner sleeve and the front end surface of the needle hub.

[0020] By improving the structure of the sheath and the sealing member and adding an inner sleeve, the sealing member is stoppered and fixed, and both the front and rear ends of the elastic member are in contact with hard materials, making the overall structure and performance more stable. More preferably, a buckle is installed on the outer wall of the inner sleeve, and a corresponding locking hole is installed on the second cylindrical segment of the sheath. When the inner sleeve is inserted into the sheath, a fixed connection between the sheath and the inner sleeve is realized by the cooperation of the buckle and the locking hole. Preferably, an annular boss is installed at the rear end port of the inner sleeve in a radially outward manner. When the front end surface of the inner sleeve abuts against the rear end surface of the sealing member, the annular boss at the rear end is exposed from the sheath and abuts against the rear end of the sheath.

[0021] It is easy to understand that in the process of using the chemical solution transfer device of the present invention, the needle seal assembly moves axially along with the expansion and contraction of the elastic member, but always maintains a state of being connected to the needle hub. As a preferred embodiment, a buckle structure is installed on both the inner surface of the front end of the inner sleeve and the front end surface of the needle hub, thereby realizing a fixed connection with the elastic member. As another preferred embodiment, an L-shaped groove composed of an axial groove and a transverse groove (a groove perpendicular to the axial direction) is installed on the side surface of the needle hub, and a radially inward sliding table is installed at the rear end of the inner sleeve. The sliding table is embedded in the L-shaped groove and can slide along the groove. By designing the positions of the sliding table and the L-shaped groove, the movable range of the needle seal assembly relative to the needle hub can be flexibly adjusted and limited. As the sliding table slides backward along the axial groove, the elastic member is compressed, and after the dispensing needle penetrates through the sealing member and reaches the set degree, when the sliding table rotates along the transverse groove, the axial movement of the needle seal assembly can be restricted, thereby achieving the effect of stopper fixation.

[0022] The sealing member is made of an elastic material, preferably one of rubber, silica gel, and synthetic rubber. The applied elastic material should conform to the relevant standards of medical materials, which is easily known and determined by those skilled in the art. As a preferred embodiment, the front end face of the sealing member protrudes outside the front end face of the sheath, so that when preparing and transferring the chemical solution, the sealing member made of an elastic material can fit into the mouth of the drug container and better seal the opening of the drug container.

[0023] The elastic member may be an elastic folding tube, a spring, etc., preferably a spring.

[0024] When using the closed chemical solution transfer device of the present invention to cooperate with the liquid transfer connector to perform the preparation and transfer operations of the chemical solution, in order to facilitate the fixed connection with the liquid transfer connector, preferably, two engaging platforms protruding radially outward are symmetrically installed on the outer wall of the front end of the sheath.

[0025] In the non-pressurized state of the closed chemical solution transfer device of the present invention, the elastic member extends axially, the sheath shields the dispensing needle inside the sheath, and due to the elastic action of the elastic material, the sealing member tightly wraps the front end of the dispensing needle, and seals the front channel openings of the inner column channel and the side ring channel inside. In the pressurized state, the elastic member is axially compressed, and the front end of the dispensing needle including the front channel openings of the inner column channel and the side ring channel can pass out of the sheath through the hole tube of the sealing member. The initial state of the closed chemical solution transfer device may be a non-pressurized state or a pressurized state, but for the purpose of preventing needle penetration, avoiding contamination, and avoiding inertial deformation of the elastic member and the sealing member, preferably, the initial state is a non-pressurized state.

[0026] Preferably, the closed chemical solution transfer device of the present invention further includes a protective cap. In the standby state, the protective cap is set on the sheath to avoid potential contamination risks.

[0027] As a second aspect of the present invention, a closed chemical liquid transfer system is further provided, and this system includes a closed chemical liquid transfer device for the double-chamber internal circulation, and a liquid transfer connector for fixedly connecting the chemical liquid transfer device to a drug container, one end of the liquid transfer connector is used for removably fixing and connecting a drug container, and the other end is used for removably fixing and connecting a chemical liquid transfer device. When fixedly connected, the front end face of the sealing member abuts against the container mouth of the drug container.

[0028] In a preferred embodiment, the liquid transfer connector includes a first sleeve and a second sleeve that are coaxial and connected to each other. The first sleeve is used for being removably sleeved on the front end of the sheath of the chemical liquid transfer device, and the second sleeve is used for being removably sleeved on the container mouth of the drug container. When fixedly connected, the front end face of the sealing member and the container mouth of the drug container maintain stable abutment within the sleeve.

[0029] More preferably, buckle claws extending axially forward are symmetrically installed on the outer edge of the second sleeve, and release arms extending rearward are installed at the rear end of each buckle claw. The second sleeve is fixed to the container mouth through the buckle claws and removed from the container mouth through the release arms.

[0030] More preferably, two engaging grooves are symmetrically installed on the inner wall of the first sleeve. The engaging groove has an L-shaped structure composed of an axial groove and a transverse groove. Correspondingly, two engaging platforms protruding radially outward are symmetrically installed on the outer wall of the front end of the sheath. When inserting the sheath into the first sleeve, the engaging platform synchronously enters the axial groove of the engaging groove. After reaching a predetermined position, when the chemical liquid transfer device is rotated so that the engaging platform rotates into the transverse groove, the chemical liquid transfer device can be fixed to the liquid transfer connector, and when operated in the reverse direction, removal and separation can be performed.

[0031] The sealed chemical solution transfer device of the present invention has the characteristics of double-chamber internal circulation. Among them, the sealed passages I and II are independent of each other. The sealed passage I communicates with the first syringe barrel and the drug container, and the sealed passage II communicates with the second syringe barrel and the drug container. After the front end of the dispensing needle pierces into the drug container, one of the first syringe barrel and the second syringe barrel is used for the transmission of the chemical solution, and the other can cooperate with the air previously inhaled into the syringe barrel by the forward and backward movement of the piston rod to achieve the purpose of balancing the air pressure.

[0032] The sealed chemical solution transfer device of the present invention may be used for purposes such as preparing a mixed drug and transferring the prepared chemical solution into an infusion bottle or an indwelling needle. After fully understanding the structure of the above-mentioned sealed chemical solution transfer device and transfer system of the present invention, it can be easily determined by those skilled in the art how to use it to prepare and transfer the chemical solution.

[0033] Taking the preparation of a chemical solution (accompanied by the dissolution of a powder drug) and injecting it into an infusion bottle as an example, the flow of using the chemical solution transfer system of the present invention may include the following steps.

[0034] (1) Pull the first piston rod of the double-chamber syringe backward until the volume of the front cavity of the first syringe barrel is larger than the volume of the chemical solution to be prepared. To perform this gas storage stage, the dispensing needle can be pierced from the sealing member in advance, reset after storing the gas, or the double-chamber syringe can be separated from the dispensing needle assembly, and then refixed and connected to the dispensing needle assembly after storing the gas.

[0035] (2) Sheath the second sleeve of the liquid transfer connector A on the bolt opening of the infusion bottle and fix it with the buckle claw. Then, hold the sheath (where the engaging platform is installed) of the chemical solution transfer device and align it and insert it into the first sleeve (where the engaging groove is installed) of the liquid transfer connector A, and rotate it to fix it. At this time, the front end face of the sealing member and the mouth of the infusion bottle are in contact within the sleeve.

[0036] (3) Hold the syringe barrel of the liquid medicine transfer device and push it forward. As the spring is compressed, the dispensing needle penetrates the sealing member and pierces into the infusion bottle. After it is completely pierced, rotate the syringe barrel (for example, clockwise) to stopper-fix the needle seal assembly and the needle hub.

[0037] (4) Pull the second piston rod of the double-chamber syringe to extract some liquid medicine (for example, physiological saline) in the infusion bottle through the sealed passage II into the second syringe barrel. At this time, a negative pressure is generated in the infusion bottle, and under the action of the internal and external pressure difference, the first piston rod advances until the internal and external air pressures are balanced, and the air reserved in the first syringe barrel is replenished into the infusion bottle.

[0038] (5) After the extraction of the liquid medicine is completed, rotate the syringe barrel in the reverse direction (for example, counterclockwise) to release the stopper-fixation of the needle seal assembly and the needle hub. Under the assistance of the elastic potential energy of the spring, move the double-chamber syringe and the dispensing needle assembly backward until the dispensing needle is reset. Then, it is pulled out from the infusion bottle and resealed by the sealing member.

[0039] (6) Twist the sheath of the liquid medicine transfer device to release the fixed connection between the liquid medicine transfer device and the liquid transfer connector A, and pull it out from the liquid transfer connector A.

[0040] (7) Set the second sleeve of the liquid transfer connector B on the bolt opening of the vial and fix it with the buckle claw. Then, hold the sheath of the liquid medicine transfer device to align and insert the first sleeve (with an engagement groove installed) of the liquid transfer connector B, and rotate and fix it. At this time, the front end face of the sealing member and the mouth of the vial are in contact within the sleeve.

[0041] (8) Hold the syringe barrel of the liquid medicine transfer device and push it forward. As the spring is compressed, the dispensing needle penetrates the sealing member and pierces into the vial. After it is completely pierced, rotate the syringe barrel (for example, clockwise) to stopper-fix the needle seal assembly and the needle hub.

[0042] (9) Push the second piston rod of the double-chamber syringe, and the drug solution is injected into the vial from the second syringe barrel through the sealed passage II. At this time, positive pressure is generated in the vial, and the air therein automatically enters the first syringe barrel through the sealed passage I, causing the first piston rod to retract.

[0043] (10) After the drug solution injected into the vial completely dissolves the original powder in the vial, pull the second piston rod, and extract the mixed drug solution in the vial into the second syringe barrel through the sealed passage II. At this time, negative pressure is generated in the vial, and the gas in the first syringe barrel is automatically replenished into the vial. Under the action of the pressure difference inside and outside the first piston rod, it advances until the internal and external air pressures are balanced.

[0044] (11) After the extraction of the mixed drug solution is completed, refer to steps (5) and (6) to reset the dispensing needle and pull out the drug solution transfer device from the liquid transfer connector B.

[0045] (12) Hold the sheath of the drug solution transfer device and re-align it to insert and rotate to fix the first sleeve of the liquid transfer connector A. At this time, the front end face of the sealing member and the mouth of the infusion bottle come into contact again inside the sleeve.

[0046] (13) After operating with reference to step (3), push the second piston rod of the double-chamber syringe, and the mixed drug solution is injected into the infusion bottle from the second syringe barrel through the sealed passage II. At this time, positive pressure is generated in the infusion bottle, and the air therein automatically enters the first syringe barrel through the sealed passage I, causing the first piston rod to retract.

[0047] (14) After the mixed drug solution is completely injected into the infusion bottle, refer to steps (5) and (6) to reset the dispensing needle and pull out the drug solution transfer device from the liquid transfer connector A.

[0048] In the above-mentioned preparation and transfer process, the second syringe transmits the chemical solution through the sealed passage II, and the first syringe moves forward and backward by the first piston rod, and cooperates with the air previously inhaled into the first syringe to balance the air pressure inside and outside the transfer system. The forward and backward movement of the first piston rod may be completed only by the action of the pressure difference inside and outside without an external force, or the progress may be flexibly adjusted with the assistance of human power.

Advantages of the Invention

[0049] Compared with the prior art, the beneficial effects of the present invention include at least the following aspects.

[0050] (1) The structure of the chemical solution transfer device of the present invention is exquisitely designed, and each member is a component that is easy to produce in lots and assemble. There is no need to use components with a relatively complex structure, and there is no need to use specific equipment.

[0051] (2) The structure and performance of the product are stable, the cost is low but the yield is high, and it is convenient to use.

[0052] (3) In the process of preparing and transferring the drug, the air pressure inside and outside the chemical solution transfer system is completely balanced.

[0053] (4) It is possible to realize the preparation and transfer of completely sealed drugs, and to minimize the risk of drug leakage, and the sealing effect is very excellent.

[0054] Hereinafter, the present invention will be further described in conjunction with the drawings.

Brief Description of the Drawings

[0055]

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Embodiments for Carrying Out the Invention

[0056] To better explain the object, technical solution and advantages of the present invention, hereinafter, in conjunction with the drawings and embodiments, the specific embodiments of the present invention will be described in more detail. The following embodiments are for explaining the present invention, but do not limit the scope of the present invention.

[0057] Example 1 As shown in Fig. 1, it is a closed chemical solution transfer device with double-chamber internal circulation, including a double-chamber syringe 10, a dispensing needle assembly 20, and a needle seal assembly 30.

[0058] The double-chamber syringe 10 is composed of a first syringe barrel 11, a first piston rod 12 that can slide back and forth along the inner cavity within the first syringe barrel 11, a second syringe barrel 14, and a second piston rod 15 that can slide back and forth along the inner cavity within the second syringe barrel 14. Here, the first syringe barrel 11 and the second syringe barrel 14 are made of a transparent material, both have the same specifications, are arranged side by side, are in the same direction, and are fixedly installed in a manner where their front ends are flush. On the surface of the barrel, there is a scale (not shown in the figure) for indicating the volume. On the front end faces of the first syringe barrel 11 and the second syringe barrel 14, a first joint 13 and a second joint 16 are respectively installed in a manner close to each other. The structures of the two joints are the same, and their outer walls are both tapered surfaces, and there is no annular boss (not shown in the figure) on the tapered surface.

[0059] The dispensing needle assembly 20 includes a dispensing needle 21 and a needle hub 22.

[0060] The dispensing needle 21 has a two-layer columnar structure composed of an inner needle tube and an outer needle tube that are fixed to each other. The inner needle tube is longer than the outer needle tube, and both ends extend to the outside of the outer needle tube. Moreover, the front end of the outer needle tube is hermetically fixed and connected to the front end side wall of the inner needle tube. The front end opening of the inner needle tube is an inclined opening, and a side opening is installed at the front end of the outer needle tube. In this way, the inner cavity of the inner needle tube constitutes the inner column channel 211, and the side ring channel 212 is constituted by the cavity between the outer needle tube and the inner needle tube.

[0061] At the rear end of the needle hub 22, a first connection hole 221 that matches the position and shape of the first joint 13 and a second connection hole 223 that matches the position and shape of the second joint 16 are installed. Inside the needle hub 22, a first channel 222 and a second channel 224 that communicate with the first connection hole 221 and the second connection hole 223 respectively and are independent of each other are installed. Here, the first channel 222 is installed coaxially with the dispensing needle 21, and the second channel 224 is installed parallel to one side of the first channel 222.

[0062] The front end of the needle hub 22 is provided with a mounting groove with an elliptical cross section, and the front end openings of the first channel 222 and the second channel 224 are both located at the bottom of the mounting groove. The needle pass-through base 23, whose external structure matches the mounting groove, is installed in the mounting groove, and the inside of the needle pass-through base 23 is provided with a hole tube that penetrates from front to back at the axis position of the corresponding prescription needle 21, and is composed of a needle pass-through hole located at the front and a fixing hole located at the rear, where the needle pass-through hole is trumpet-shaped (to facilitate the installation of the prescription needle 21), and the inner diameter to the fixing hole gradually decreases from front to rear, and the inner diameter of the fixing hole matches the outer diameter of the outer needle tube. The rear end surface of the needle pass-through base 23 is further provided with a communication groove, and both ends are respectively connected to the second channel 224 and the fixing hole.

[0063] The dispensing needle 21 is fixedly connected to the needle hub 22 by embedding its rear end in the needle hub 22. At this time, the rear end of the inner needle tube passes through the hole tube of the needle passer 23 and is fixed in the first channel 222 by embedding, and the rear end of the outer needle tube passes through the needle passer hole and is fixed in the fixing hole of the needle passer 23 by embedding.

[0064] By embedding the first coupling 13 and the second coupling 16 into the first connecting hole 221 and the second connecting hole 223 respectively, the dispensing needle assembly 20 and the dual chamber syringe 10 achieve a fixed and sealed connection.

[0065] Needle seal assembly 30 includes a coaxially mounted sheath 31, a sealing member 32, a resilient member 33, and an inner sleeve 34.

[0066] The front end of the sheath 31 has a relatively small radial size and forms a composite cylindrical structure composed of a first cylindrical segment with a relatively small inner diameter and a second cylindrical segment with a relatively large inner diameter. Two engagement bases that protrude radially outward are symmetrically provided on the outer wall of the first cylindrical segment for fixed connection to the liquid transfer connector, and two locking holes are symmetrically provided on the cylindrical wall near the rear end opening of the second cylindrical segment.

[0067] The sealing member 32 is made of silica gel, has a cross-section presenting an inverted T-shaped structure, the diameter of its front part is equal to the inner diameter of the first cylindrical segment of the sheath 31, and the length is slightly longer than the axial length of the first cylindrical segment. The diameter of the rear part is equal to the inner diameter of the second cylindrical segment. The sealing member 32 completely fills the inner cavity of the first cylindrical segment and the front-end inner cavity of the second cylindrical segment. At the same time, the front-end face protrudes outward beyond the front-end face of the sheath 31. A hole tube for the dispensing needle 21 to pass through is provided on the central axis of the sealing member 32, and the inner diameter of the hole tube is smaller than the outer diameter of the dispensing needle 21.

[0068] The inner diameter and outer diameter of the inner sleeve 34 correspond to the outer diameter of the needle hub 22 and the inner diameter of the second cylindrical segment of the sheath 31 respectively. Its front-end face is sealed, and a through hole for the dispensing needle 21 to pass through is provided at the center of the end face. An annular boss is installed at the rear end port in a radially outward manner, and two buckles matching the locking holes are symmetrically installed on the outer wall close to the rear end port.

[0069] The inner sleeve 34 is inserted into the second cylindrical segment of the sheath 31, and a fixed connection between the two is realized by the cooperation of the buckle and the locking hole. At the same time, the front-end face of the inner sleeve 34 abuts against the rear-end face of the sealing member 32, and the annular boss at the rear end is exposed from the sheath 31 and abuts against the rear end of the sheath 31.

[0070] The elastic member 33 is a spring and is installed inside the inner sleeve 34. Both ends respectively abut against the inner front surface of the inner sleeve 34 and the front-end face of the needle hub 22.

[0071] An L-shaped groove composed of two axial grooves and a transverse groove is symmetrically installed on the side surface of the needle hub 22. Correspondingly, two sliding tables are symmetrically installed inward in the radial direction at the rear end of the inner sleeve 34. The sliding tables are embedded in the L-shaped groove and can slide along the groove.

[0072] As shown in Fig. 1a, the closed - type chemical solution transfer device is in a non - pressurized state. The elastic member extends axially. The slide table of the inner sleeve 34 is located at the front end of the axial groove on the side surface of the needle hub 22. The sheath 31 shields the dispensing needle 21 inside the sheath 31. Under the elastic action of the silica gel, the sealing member 32 tightly wraps the front end of the dispensing needle 21, and seals the front - end channel openings of the inner column channel 211 and the side ring channel 212 inside.

[0073] In the closed - type chemical solution transfer device of Fig. 1a, the dispensing needle assembly 20 is fixedly and hermetically connected to the double - chamber syringe 10. The inner column channel 211, the first channel 222, the first connection hole 221 and the first syringe barrel 11 communicate in sequence from front to back, forming a sealed passage I. The side ring channel 212, the second channel 224, the second connection hole 223 and the second syringe barrel 14 communicate in sequence from front to back, forming a sealed passage II. The sealed passage I and II are independent of each other.

[0074] Fig. 1b is a schematic cross - sectional structure diagram of the above - mentioned chemical solution transfer device in the axially pressurized state. In the pressurized state, the spring is axially compressed, and the front end of the dispensing needle 21 including the front - end channel openings of the inner column channel 211 and the side ring channel 212 exits from the sheath 31 through the hole tube of the sealing member 32. The slide table of the inner sleeve 34 slides synchronously backward along the axial groove and moves to the lateral groove through the rotating double - chamber syringe 10 or the sheath 31, thereby restricting the axial movement of the needle seal assembly 30 and achieving the effect of stopper fixation.

[0075] Figs. 2a and 2b show schematic cross - sectional structure diagrams of local perspectives of the above - mentioned chemical solution transfer device in the non - pressurized and pressurized states.

[0076] Figure 3 is a representative actual diagram of the chemical solution transfer device of the present invention. In the figure, Figure 3a is an actual diagram of the sample in the standby state, Figure 3b is an actual diagram of the sample after the double-chamber syringe, the dispensing needle assembly and the needle seal assembly are separated from each other, and Figure 3c is an actual diagram of the sample after each member is separated (here, in order to more comprehensively and clearly show the internal structure, the inner needle tube and the outer needle tube of the dispensing needle are presented separately).

[0077] Example 2 Shown in Figure 4 is a closed chemical solution transfer system, which includes a closed chemical solution transfer device with double-chamber internal circulation (as shown in Figures 1 to 3 and not fully presented in Figure 4) and a pipetting connector 40 for fixedly connecting the chemical solution transfer device to a drug container.

[0078] The pipetting connector 40 includes a first sleeve 41 and a second sleeve 42 that are coaxial and connected to each other.

[0079] The first sleeve 41 is used to be removably sleeved on the front end of the sheath 31 of the chemical solution transfer device. Corresponding to the engaging platform on the outer wall of the front end of the sheath 31, two engaging grooves 45 are symmetrically installed on the inner wall of the first sleeve 41. The engaging groove 45 has an L-shaped structure composed of an axial groove and a transverse groove. When inserting the sheath 31 into the first sleeve 41, the engaging platform synchronously enters the axial groove of the engaging groove. After reaching a predetermined position, when the chemical solution transfer device is rotated so that the engaging platform rotates into the transverse groove, the chemical solution transfer device can achieve fixation with the pipetting connector.

[0080] The second sleeve 42 is used to be removably sleeved on the container mouth of the drug container. On the outer edge of the second sleeve 42, buckle claws 43 extending axially forward are symmetrically installed, and at the rear end of each buckle claw 43, a release arm 44 extending rearward is installed. The second sleeve 42 is fixed to the container mouth through the buckle claws 43 and removed from the container mouth through the release arms 44.

[0081] When the chemical liquid transfer device and the drug container are fixed and connected via the pipetting connector 40, the front end face of the sealing member 32 and the container mouth of the drug container maintain stable contact within the sleeve.

[0082] In the chemical liquid transfer system shown in Fig. 4a, the chemical liquid transfer device and the pipetting connector are in an unconnected state. Fig. 4b is a schematic cross-sectional structure diagram in the connected state of the chemical liquid transfer device and the pipetting connector in the chemical liquid transfer system. Fig. 4c is a schematic cross-sectional structure diagram in the operating state of the chemical liquid transfer system.

[0083] Fig. 5 is a representative actual diagram of the chemical liquid transfer system of the present invention. In the figure, Fig. 5a is an actual sample diagram in the standby state, and Figs. 5b and 5c are actual sample diagrams at different angles when the infusion bottle and the vial are fixed and connected to the pipetting connector.

[0084] Application Example 1 As described above, the performance superiority of the chemical liquid transfer device and the chemical liquid transfer system of the present invention compared with the prior art has been described in detail. In order to further verify its technical effect, currently, application experiments are being carried out using actual products.

[0085] 1. Experiment location Product Research and Development Laboratory of Zhanjiang Jianliyuan Medical Supplies Co., Ltd.

[0086] 2. Experiment object The chemical liquid transfer system shown in Fig. 5 is adopted as the experimental sample. Among them, the chemical liquid transfer device is as shown in Fig. 3, and the specifications of the first and second syringes are 20 mL.

[0087] Add 10 mL of an aqueous solution of sodium fluorescein with a concentration of 10 g / L to the vial, seal it with an aluminum cap and a chlorinated butyl rubber stopper to obtain vial A. Take another empty vial, seal it in the same way with an aluminum cap and a chlorinated butyl rubber stopper to obtain vial B as a standby.

[0088] 3. Experiment method 1) The first piston rod of the double-chamber syringe was pulled backward until the volume of the front cavity of the first syringe barrel became larger than 10 mL. To perform this gas storage operation, the double-chamber syringe was separated from the dispensing needle assembly, gas was stored, and then it was re-fixed and connected to the dispensing needle assembly.

[0089] 2) The second sleeve of the pipetting connector A was sleeved on the bolt mouth of the vial A and fixed thereto using the buckle claw. Then, with the sheath of the chemical solution transfer device, alignment was carried out and the first sleeve of the pipetting connector A was inserted and rotated to be fixed. At this time, the front end face of the sealing member and the mouth of the vial A were in contact within the sleeve.

[0090] 3) Hold the syringe barrel of the chemical solution transfer device and push it forward. Along with the compression of the spring, the dispensing needle pierced through the sealing member and into the vial A. After it was completely pierced, the syringe barrel was rotated, and the needle seal assembly and the needle hub were stopper-fixed.

[0091] 4) Pull the second piston rod of the double-chamber syringe, extract the solution in the vial A through the sealing passage II into the second syringe barrel. At this time, a negative pressure was generated in the vial A, and under the action of the internal and external pressure difference, the first piston rod advanced, and the air reserved in the first syringe barrel was replenished into the vial A until the internal and external air pressures were balanced.

[0092] 5) After the extraction of the solution was completed, the syringe barrel was rotated in the reverse direction, the stopper fixation between the needle seal assembly and the needle hub was released, and with the assistance of the elastic potential energy of the spring, the double-chamber syringe and the dispensing needle assembly were moved backward until the dispensing needle was reset and withdrawn from the vial A and resealed with the sealing member.

[0093] 6) The sheath of the chemical solution transfer device was twisted to release the fixed connection between the chemical solution transfer device and the pipetting connector A, and it was pulled out from the pipetting connector A.

[0094] 7) The second sleeve of the pipetting connector B was sleeved on the bolt opening of the vial B and fixed thereto using the buckle claws. Then, with the sheath of the chemical solution transfer device, alignment was carried out and it was inserted into the first sleeve of the pipetting connector B and rotated and fixed. At this time, the front end face of the sealing member and the mouth of the vial B were in contact within the sleeve.

[0095] 8) Hold the syringe barrel of the chemical solution transfer device and push it forward. As the spring is compressed, the dispensing needle penetrated the sealing member and pierced into the vial B. After it was completely pierced, the syringe barrel was rotated and the needle seal assembly and the needle hub were stopper-fixed.

[0096] 9) Push the second piston rod of the double-chamber syringe, and the solution was injected into the vial B from the second syringe barrel through the sealed passage II. At this time, a positive pressure was generated in the vial B, and the air therein automatically entered the first syringe barrel through the sealed passage I, and the first piston rod was retracted.

[0097] 10) After the solution was completely injected into the vial B, referring to steps (5) and (6), the dispensing needle was reset and the chemical solution transfer device was pulled out from the pipetting connector B.

[0098] Detection was carried out on the chemical solution transfer system at different stages in the above process using a triple-purpose ultraviolet analyzer (model number: ZF-1). The specific method was to place the chemical solution transfer system on the operating table of the triple-purpose ultraviolet analyzer, turn on the device and irradiate ultraviolet light thereon, and observe whether fluorescent spots appeared in a specific area.

[0099] 4. Experimental Results The detection results obtained using the triple-purpose ultraviolet analyzer are as shown in FIG. 6.

[0100] FIG. 6a is a fluorescence display diagram after the chemical solution transfer device was fixed and connected to the vial A through the pipetting connector A, presenting the initial fluorescence state at the time of connection. Note: Since only the initial fluorescence state was presented, no gas was previously stored in the first syringe barrel.

[0101] Figure 6b is a fluorescence display diagram of the chemical solution transfer system after the aforementioned steps 1) to 6) are completed. As can be seen from it, there was no fluorescence at the contact part between vial A and the chemical solution transfer device. This indicates that the extraction process of the sodium fluorescein aqueous solution was completed under a completely sealed situation, the sealing performance of the chemical solution transfer system was extremely good, and there was no leakage at all at the contact part between vial A and the chemical solution transfer device.

[0102] Figure 6c is a system fluorescence display diagram after a part of the sodium fluorescein aqueous solution was injected into vial B during the process of performing the aforementioned step 9), the operation was temporarily stopped, and then the chemical solution transfer device and the liquid transfer connector B were separated. As can be seen from it, there was no fluorescence at the contact part between vial B and the chemical solution transfer device. Except for a small amount of permeable fluorescence due to the adhesion residue inside the second syringe filled with the sodium fluorescein aqueous solution and the liquid channel of the solution in the chemical solution transfer device, no fluorescence phenomenon appeared in the sample appearance. These phenomena indicate that the chemical solution transfer system of the present invention has extremely good sealing performance, and both the sealed passages I and II play their respective roles and do not interfere with each other.

[0103] In addition, when using the chemical solution transfer system of the present invention, since it can be ensured that the pressure inside and outside the vial is always equal, the suction and injection of the solution are very smooth, and there is no problem that it is necessary to overcome the pressure difference between the inside and outside of the vial and further make the operation difficult.

[0104] Application Example 2 In order to further verify the sealing performance in the process of preparing and transferring the chemical solution of the chemical solution transfer device and the chemical solution transfer system of the present invention, an application experiment was carried out by using an odorous solution in combination.

[0105] 1. Experiment location Product Research and Development Laboratory of Zhanjiang Jianliyuan Medical Supplies Co., Ltd.

[0106] 2. Experiment object The chemical solution transfer system shown in Fig. 5 was adopted as an experimental sample. Among them, the chemical solution transfer device is as shown in Fig. 3, and the specifications of the first and second syringes are 20 mL.

[0107] In the ventilation room of the laboratory, 10 mL of an odorant solution with a garlic odor concentration of 0.1 g / L was added to a vial, sealed with an aluminum cap and a chlorinated butyl rubber stopper. Then, the outer surface was thoroughly washed and dried to make it odorless, and it was designated as vial A. Another empty vial was taken and sealed in the same way with an aluminum cap and a chlorinated butyl rubber stopper, designated as vial B, and reserved as a spare.

[0108] 3. Experimental method In an independent and sealed laboratory with an area of about 12 square meters, referring to the steps of Application Example 1, all of the odorant solution with a garlic odor in vial A was transferred to vial B.

[0109] After that, three men and three women aged between 26 and 43, with healthy bodies and normal olfaction, were selected, entered the laboratory and stayed for 30 seconds, and gave feedback on whether there was a corresponding smell and its intensity.

[0110] 4. Experimental results According to the feedback results, among the six tested personnel, three men and two women reported no smell, and one woman reported that there was a very slight abnormal smell in the air, but the type of smell could not be determined. This result further demonstrated the complete sealing effect in the preparation and transfer process of the chemical solution of the chemical solution transfer system of the present invention, and could minimize the risk of drug leakage, and the sealing effect was very excellent.

[0111] The above embodiments mainly describe the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that this application is not limited by the above embodiments, and the above embodiments and the description in the specification only explain the principles of the present invention. On the premise of not departing from the spirit and scope of the present invention, various changes and improvements can be made to the present invention, and all of these changes and improvements should be understood to be included within the scope of the present invention that claims protection.

Explanation of Reference Numerals

[0112] 10, double-chamber syringe; 11, first syringe barrel; 12, first piston rod; 13, first joint; 14, second syringe barrel; 15, second piston rod; 16, second joint; 20, dispensing needle assembly; 21, dispensing needle; 211, inner column channel; 212, side ring channel; 22, needle hub; 221, first connection hole; 222, first channel; 223, second connection hole; 224, second channel; 23, needle-passing base; 30, needle seal assembly; 31, sheath; 32, sealing member; 33, elastic member; 34, inner sleeve; 40, liquid transfer connector; 41, first sleeve; 42, second sleeve; 43, buckle claw; 44, release arm; 45, engagement groove.

Claims

1. A double-chamber internal circulation closed-type chemical liquid transfer device including a double-chamber syringe (10), a dispensing needle assembly (20), and a needle seal assembly (30), The double-chamber syringe (10) is composed of a first syringe barrel (11), a first piston rod (12) that can slide back and forth along the inner cavity in the first syringe barrel (11), a second syringe barrel (14), and a second piston rod (15) that can slide back and forth along the inner cavity in the second syringe barrel (14). Here, the first syringe barrel (11) and the second syringe barrel (14) are arranged side by side, in the same direction, and are fixedly installed in a manner where the front ends are flush. On the front end face of the first syringe barrel (11), a first joint (13) is installed, and on the front end face of the second syringe barrel (14), a second joint (16) is installed. The dispensing needle assembly (20) includes a dispensing needle (21) and a needle hub (22). The dispensing needle (21) is fixedly connected to the needle hub (22) in a manner where its rear end is embedded in the front end of the needle hub (22). Here, At the rear end of the needle hub (22), a first connection hole (221) that matches the first joint (13) and a second connection hole (223) that matches the second joint (16) are installed. And inside the needle hub (22), a first channel (222) and a second channel (224) that are respectively in communication with the first connection hole (221) and the second connection hole (223) and are independent of each other are installed. The dispensing needle (21) has a two-layer columnar structure and has an inner column channel (211) and a side ring channel (212). Here, the inner column channel (211) is in communication with the first channel (222), and the side ring channel (212) is in communication with the second channel (224). The dispensing needle (21) is composed of an inner needle tube and an outer needle tube. The inner needle tube is bored inside the outer needle tube, and both ends extend outside the outer needle tube. At this time, the inner column channel (211) is formed by the inner cavity of the inner needle tube, and the side ring channel (212) is formed by the cavity between the outer needle tube and the inner needle tube. By embedding the first joint (13) and the second joint (16) into the first connection hole (221) and the second connection hole (223) respectively, the dispensing needle (21) assembly (20) and the double-chamber syringe (10) achieve a fixed and sealed connection. The needle seal assembly (30) includes a sheath (31) installed coaxially with the dispensing needle (21), a sealing member (32), and an elastic member (33). Here, The sheath (31) has a hollow cylindrical structure with openings at both the front and the rear, and is sleeved on the front end of the needle hub (22) so as to be axially movable. The sealing member (32) is made of an elastic material and is fixedly installed inside the front-end cylinder of the sheath (31). A hole tube for the dispensing needle (21) to pass through is provided on the central axis of the sealing member (32), and the inner diameter of the hole tube is smaller than the outer diameter of the dispensing needle (21). The elastic member (33) is installed between the sealing member (32) and the needle hub (22). Depending on the needle hub (22), the elastic member (33) provides axial elastic support to the front-end sealing member (32). In the non-pressurized state, the elastic member (33) extends axially. The sheath (31) shields the dispensing needle (21) inside the sheath (31). Due to the elastic action of the elastic material, the sealing member (32) tightly wraps the front-end portion of the dispensing needle (21), sealing the front-end channel openings of the inner column channel (211) and the side ring channel (212) inside. In the pressurized state, the elastic member (33) is axially compressed, and the front-end portion of the dispensing needle (21) including the front-end channel openings of the inner column channel (211) and the side ring channel (212) can pass through the hole tube of the sealing member (32) and exit from the sheath (31). The needle seal assembly (30) includes a sheath (31) installed coaxially, a sealing member (32), an elastic member (33), and an inner sleeve (34). Here, The front-end portion of the sheath (31) has a smaller radial size, forming a composite cylindrical structure composed of a first cylindrical segment with a relatively small inner diameter and a second cylindrical segment with a relatively large inner diameter. The sealing member (32) is designed to have an inverted T-shaped cross-section. The diameter of the front part corresponds to the inner diameter of the first cylindrical segment, and the diameter of the rear part corresponds to the inner diameter of the second cylindrical segment. Thus, the sealing member (32) can completely fill the inner cavity of the first cylindrical segment and at the same time fill at least part of the inner cavity of the second cylindrical segment. The inner diameter of the inner sleeve (34) corresponds to the outer diameter of the needle hub (22). The outer diameter of the inner sleeve (34) corresponds to the inner diameter of the second cylindrical segment of the sheath (31). Its front end face is sealed, and a through hole for the dispensing needle (21) to pass through is provided at the center of the end face. The inner sleeve (34) is fixedly connected inside the second cylindrical segment of the sheath (31), and the front end face abuts against the rear end face of the sealing member (32). The elastic member (33) is installed inside the inner sleeve (34), and both ends abut against the inner surface of the front end of the inner sleeve (34) and the front end face of the needle hub (22) respectively. A double-chamber internal circulation sealed chemical liquid transfer device, characterized by the above.

2. The outer walls of the first joint (13) and the second joint (16) are tapered surfaces, and at least one annular boss is provided on the tapered surface. Accordingly, the shapes of the first connection hole (221) and the second connection hole (223) provided at the rear end of the needle hub (22) respectively match the tapered surfaces of the corresponding joints, and annular grooves corresponding to the annular bosses are provided on the hole walls. The sealed chemical liquid transfer device according to claim 1, characterized by the above.

3. An attachment groove is provided at the front end of the needle hub (22), and a needle passing base (23) with an outer shape structure matching the attachment groove is mounted in the attachment groove. The front end openings of the first channel (222) and the second channel (224) are both located at the bottom of the attachment groove, and the position of the front end opening of the first channel (222) is coaxial with the dispensing needle (21). Inside the needle-passing base (23), a hole tube that penetrates front and back is installed at a position corresponding to the axis of the dispensing needle (21), and it is composed of a needle-passing hole located at the front part and a fixing hole located at the rear part. The needle-passing hole is trumpet-shaped, and the inner diameter shrinks from the front to the rear until the fixing hole. The inner diameter of the fixing hole matches the outer diameter of the outer needle tube. A communication groove is installed on the rear end face of the needle-passing base (23), and both ends communicate with the second channel (224) and the fixing hole respectively. The rear end of the inner needle tube of the dispensing needle (21) passes through the needle-passing base (23) and is fixed in the first channel (222) in an embedded manner. The rear end of the outer needle tube is fixed in the fixing hole of the needle-passing base (23) in an embedded manner. The closed-type chemical liquid transfer device according to claim 1, characterized in that.

4. After the dispensing needle assembly (20) and the double-chamber syringe (10) are fixed and hermetically connected, the inner column channel (211), the first channel (222), the first connection hole (221) and the first syringe barrel (11) communicate in sequence from the front to the rear to form a sealed passage I. The side-ring channel (212), the second channel (224), the second connection hole (223) and the second syringe barrel (14) communicate in sequence from the front to the rear to form a sealed passage II. The sealed passage I and II are independent of each other. The closed-type chemical liquid transfer device according to any one of claims 1 to 3, characterized in that.

5. An annular boss is installed at the rear end port of the inner sleeve (34) in a radially outward direction. When the front end face of the inner sleeve (34) abuts against the rear end face of the sealing member (32), the annular boss at the rear end is exposed from the sheath (31) and abuts against the rear end of the sheath (31). The closed-type chemical liquid transfer device according to claim 1, characterized in that.

6. A closed-type chemical liquid transfer system, The closed-type chemical liquid transfer device according to any one of claims 1 to 3, and a liquid transfer connector (40) for fixedly connecting the closed-type chemical liquid transfer device to a drug container. One end of the pipetting connector (40) is used for removably fixing and connecting a drug container, and the other end is used for removably fixing and connecting a drug solution transfer device. When fixedly connected, the front end face of the sealing member abuts against the container mouth of the drug container, a closed drug solution transfer system.

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