Active ingredient delivery system

Abstract

An active ingredient delivery system and method of making the same. The system may include a matrix disposed on a substrate. The matrix includes an active ingredient component, a carrier, and optionally a flavor component, and optionally additional components. The active ingredient delivery system may provide the active ingredient to a user via absorption into the user's gums.

Description

Technical Field

[0001] The subject matter disclosed herein generally relates to an active ingredient delivery system for delivering an active ingredient to a user. More particularly, the subject matter disclosed herein relates to, for example, a paper-based product subjected to screen printing with a matrix having an active ingredient element such as nicotine. The matrix may further contain a softening agent such as glycerin. When a paper-based substrate containing the matrix is placed on a user's gum, the active ingredient can be absorbed by or released to the user. The active ingredient delivery system may further contain a flavor element that imparts a flavor to the active ingredient delivery system.

Background Art

[0002] Existing active ingredient delivery systems typically have harmful side effects or undesirable qualities for consumers. For example, nicotine is often delivered to users via tobacco smoking, which has many well-known harmful side effects. Alternatively, nicotine may be delivered via chewing gum substances or, alternatively, via sachets divided into single servings known as tobacco-containing snus. However, chewing gum and snus are often not standalone and not suitable for all situations. So-called "white pouch products", which are a variation of snus where the tobacco content of the snus pouch is replaced with nicotine and flavor absorbed in cellulose pulp, also have similar drawbacks in that they are not standalone and not suitable for all situations. Such white pouch products are less harmful and have side effects, but because their maximum moisture content is approximately 30%, their shelf life is limited and optimal absorption of the active ingredient by the user is hindered. Therefore, there is a need for a single active ingredient delivery system that is not harmful to users and has optimal user characteristics.

[0003] As another example, caffeine is often ingested via a drinkable liquid (e.g., coffee, energy drink) or in the form of tablets. Drinkable liquids containing caffeine are also not standalone and not suitable for all situations, and are often contained in plastic containers or coated aluminum containers that may generate a large amount of environmental waste compared to paper-based products. Further, the user has to carry around a relatively bulky liquid container. Caffeine in the form of tablets is similarly inconvenient as it requires a drinkable liquid to aid ingestion.

[0004] The active ingredient delivery system of the present invention provides a convenient, standalone paper-based product that delivers an active ingredient to a user by applying a paper-based product to the gums. Preferably, the delivery system of the present invention has an optimal shelf life and user characteristics with little or no harmful side effects to the user.

Summary of the Invention

[0005] It should be understood that this summary is not an extensive overview of the present disclosure. This summary is exemplary and not restrictive, and is not intended to identify key or critical components of the present disclosure or to define its scope. The sole purpose of this summary is to introduce specific concepts of the present disclosure by way of explanation and illustration for the following detailed description.

[0006] An active ingredient delivery system is disclosed. The system comprises a paper-based substrate and a matrix. The matrix may include an active ingredient element and a carrier. The matrix may be disposed on the paper-based substrate, may be printed in some embodiments, and may be screen printed in further embodiments. The matrix may optionally further include one or more of a flavor element, a softening agent, a viscosity modifier, an additional carrier, and a sweetener. The paper-based substrate may have dimensions of length, width, and depth such that the paper-based substrate on which the matrix is disposed fits the user's gums.

[0007] In another embodiment of the present invention, the active ingredient delivery system comprises a paper-based substrate having a plurality of connected segments such as strip pieces. In one embodiment, the plurality of segments are connected via perforations. The active ingredient delivery system further comprises a matrix. The matrix may include an active ingredient element and a carrier. Further, the matrix may include a flavor element, a softening agent and / or a sweetener. The carrier, the softening agent, the flavor element and the sweetener are preferably food grade. The matrix may be disposed on the paper-based substrate. In an embodiment incorporating perforations, the perforations allow a user to easily tear off one of the plurality of segments of the paper-based substrate on which the matrix is disposed. Further, each of the segments has dimensions of length, width and thickness such that when separated, the segment fits onto the user's gum.

[0008] The present invention also includes a method of manufacturing an active ingredient delivery system. The method may include the step of providing a paper-based substrate and, in some embodiments, the step of disposing a matrix on the paper-based substrate via printing, wherein the matrix includes an active ingredient element and a carrier. In one embodiment of the disclosed method, the step of disposing the matrix on the paper-based substrate is achieved via printing. In one aspect of such an embodiment, refilling of the matrix onto the substrate is achieved using a metering pump during each printing run. The method may further include the step of sizing the paper-based substrate on which the matrix is disposed to dimensions of length, width and thickness such that the paper-based substrate fits onto the user's gum.

[0009] In an alternative embodiment, the method may include the steps of preparing a paper-based substrate and disposing a matrix on the paper-based substrate. In one embodiment, the matrix includes an active ingredient element and at least one carrier. Further, the matrix may include at least one of a flavor element, a softening agent, a viscosity modifier, an additional carrier, and a sweetening agent. In a preferred embodiment of the disclosed method, the step of disposing the matrix on the paper-based substrate may be accomplished via screen printing. In one aspect of such an embodiment, refilling of the matrix onto the substrate may be accomplished using a metering pump while each screen printing is being performed. The method may further include the step of perforating the paper-based substrate, whereby segments such as strip pieces are connected and separated via the perforations. The segments may have dimensions of length, width, and thickness such that each segment that absorbs or releases the active ingredient element fits onto the user's gum.

[0010] In a further embodiment, the invention includes a product manufactured according to any of the above methods.

[0011] These and other features and their advantages will become apparent by carefully considering the following detailed description accompanied by the attached drawings.

[0012] The above aspects of the invention, as well as other apparent aspects, advantages, and objectives, will become apparent from the following detailed description in combination with the drawings.

Brief Description of the Drawings

[0013]

Figure 1

Figure 2

Modes for Carrying Out the Invention

[0014] The present invention can be more easily understood by referring to the following detailed description, examples, drawings, and claims, as well as the description before and after them. However, it should be understood that the present invention is not limited to the specific devices, systems, and / or components disclosed, and thus can be modified, unless otherwise specified. Also, it should be understood that the technical terms used in this specification are only for describing specific aspects and are not intended to be limiting.

[0015] As used in this specification and the appended claims, the singular forms "a," "an," and "the" when used to specify a quantity include a plurality of objects unless the context clearly dictates otherwise.

[0016] Unless otherwise specified, the following terms used in this specification and the claims have the meanings shown below.

[0017] As used herein, the term "matrix" refers to a combination of substances. The matrix used herein may include one or more active ingredient elements, one or more fluid or solid carriers such as propylene glycol, one or more flavor elements, a softening agent such as glycerin, one or more viscosity modifiers, and one or more sweeteners. The matrix may be solid or liquid itself while being prepared for placement on a paper-based product, but can take a liquid form during printing. The "liquid" as intended by this definition includes fluids and further includes gels and pastes that can be used for printing, but is not limited thereto. When the matrix is printed on a paper-based substrate, the "matrix" may refer to one or more liquids that are printed together as one mixture in one or more printing runs or printed as separate mixtures containing different matrix elements in separate printing runs. Whether the matrix is printed as one mixture or as separate mixtures, when the present disclosure refers to the amount of an element of the matrix ("a" or "the" matrix), unless the context otherwise indicates, such measurements are intended to be interpreted as part of the entire matrix (i.e., relative to the total of all mixtures in the matrix). The matrix may remain fluid when placed on a paper-based product or may form a dried solid film or coating. The matrix may further partially or completely impregnate the paper-based product when applied to or after being applied to the paper-based product.

[0018] As used herein, the term "paper-based product" refers to any cellulose-based or cellulose pulp-based product that can maintain its structure when the matrix as defined herein is placed thereon. The "paper-based product" can be manufactured in a conventional or improved paper mill. Generally, standard paper-based products used in the food industry and food packaging industry are contemplated by the use of the term "paper-based product", but in the present disclosure, preferred embodiments having specific constituent material contents particularly useful for the disclosed invention are identified.

[0019] As used in this disclosure, the term "moisture content" when used with respect to an active ingredient delivery system refers to the weight percentage of the active ingredient delivery system that is derived from a liquid source. The moisture content is determined by first weighing a dry substrate and then disposing it, such as by coating a material containing a matrix onto the substrate. The substrate with the matrix coated thereon is weighed again immediately after coating, the weight of the dry substrate is subtracted from the weight of the substrate with the matrix coated thereon, that weight is divided by the weight of the substrate with the matrix coated thereon, and multiplied by 100 to obtain a percentage value to determine the moisture content. For example, when weighing a dry sheet, its weight is 100 grams. After printing a matrix on the dried substrate and then weighing the substrate with the matrix applied, its weight is 181 grams. Subtracting 100 grams of the dry substrate from the 181 - gram sheet with the matrix printed thereon gives a weight of 81 grams of liquid. Dividing 81 grams of liquid by 181 grams (the weight of the substrate with the matrix printed thereon) and multiplying by 100 gives a moisture content of approximately 45%. Any suitable calibrated scale can be used for weight measurements.

[0020] As used herein, the term "active ingredient element" refers to a substance that, when absorbed or released into the body, produces a chemical or biological effect on the user and can be disposed on a paper - based product as defined herein. These materials include, but are not limited to, substances in pure form, or substances contained in liquids, solids, or other carriers, such as nicotine, CBD, THC, caffeine, ibuprofen, pharmaceuticals, vitamins, glucose, or other natural or synthetic sugars, other substances, and mixtures thereof. As used herein, the compositional amount of an "active ingredient element" refers to the amount of the active ingredient element without including solvents, vehicles, or other carriers, unless otherwise indicated in the context. "Active ingredient" is generally synonymous with "active ingredient element" as used herein.

[0021] As used herein, the term "food - grade" refers to any substance or element that is safe for human ingestion / absorption.

[0022] As used herein, the term "CBD" refers to cannabidiol, a phytocannabinoid discovered in 1940. It is one of 113 identified cannabinoids in the cannabis plant, along with tetrahydrocannabinol (THC). CBD accounts for approximately up to 40% of the cannabis plant extract. The term "CBD", as used herein, refers to CBD extract, which may contain impurities and other compounds specific to the extraction process.

[0023] As used herein, the term "THC" refers to tetrahydrocannabinol, a lipid present in the cannabis plant. THC is the main psychoactive ingredient of the cannabis plant and is one of at least 113 total cannabinoids identified in the cannabis plant. The chemical formula of THC, C 21 H 30 O2 has multiple isomers described, but the term "THC" as used herein generally refers to the delta-9-THC isomer of the chemical name (-)-trans-Δ 9 -tetrahydrocannabinol. However, the term "THC" as used herein refers to THC extract, which may be assumed to contain impurities specific to the extraction process, other isomers of THC of the formula C 21 H 30 O2, and other compounds.

[0024] As used herein, the term "softening agent" refers to a material that softens a substrate, preferably to assist the user experience, by improving or maintaining the texture of a paper-based substrate with a matrix disposed thereon. A "softening agent" may also help facilitate handling during the manufacturing process. Preferably, the "softening agent" of the present invention is food grade as defined herein. One exemplary softening agent contemplated in the present disclosure is glycerin. Suitable softening agents shall not have a significant adverse effect on the absorbency of the paper-based substrate to which they are applied.

[0025] When used with respect to an element that may be present in a mixture, the term "substantially free of" means containing less than about 2% by weight of the element, based on the weight of the mixture.

[0026] The recitation of numerical ranges using endpoints includes all numbers subsumed within that range (e.g., 1 to 5 includes 1, 1.5, 2, 2.75, 3, 3.80, 4, 5, etc.).

[0027] The terms "preferred" and "preferably" refer to embodiments of the invention that may provide certain benefits under certain circumstances. However, in the same or other circumstances, other embodiments may be preferred. Further, the recitation of one or more preferred embodiments does not imply that other embodiments are not useful, nor is it intended to exclude other embodiments from the scope of the invention.

[0028] The accompanying drawings illustrate some of the foregoing aspects of the active ingredient delivery system and additional aspects thereof. The drawings represent embodiments of the invention and are not intended to limit the invention.

[0029] The disclosed subject matter includes an active ingredient delivery system. The system of the invention preferably places a matrix-disposed paper-based product on a user's gum such that an active ingredient, e.g., nicotine, CBD, THC, caffeine, ibuprofen, pharmaceuticals, sugars, vitamins, other substances, or mixtures thereof, is delivered to the user by being absorbed or released into the user's body.

[0030] Although this specification is mainly described with respect to delivering an active ingredient to a human via the mouth and / or gums, it will be apparent that the disclosed subject matter can have various other delivery locations and can also be used in non-humans such as pets.

[0031] Reference is now made in detail to embodiments and examples of the disclosed subject matter. The described embodiments, as well as other conditions and details, are not to be construed as unduly limiting the scope of the disclosed subject matter.

[0032] The present invention includes an active ingredient delivery system. The system can include a paper-based substrate and a matrix, and the matrix includes an active ingredient element and a carrier. The matrix may be disposed on the paper-based substrate, may be printed in some embodiments, and may be screen-printed in further embodiments. Optionally, the matrix may further include one or more of a flavor element, a softening agent, a viscosity modifier, an additional carrier, and a sweetener. The paper-based substrate can have dimensions of length, width, and thickness such that the paper-based substrate on which the matrix is disposed fits the user's gum.

[0033] In another embodiment of the present invention, the active ingredient delivery system comprises a paper-based substrate having a plurality of connected segments such as strip pieces. In one embodiment, the plurality of segments are connected via perforations. The active ingredient delivery system further comprises a matrix. The matrix may include an active ingredient element and a carrier. Additionally, the matrix may include a flavor element, a softening agent, and / or a sweetener. The carrier, softening agent, flavor element, and sweetener are preferably food grade. The matrix may be disposed on the paper-based substrate. In embodiments incorporating perforations, the perforations allow the user to easily tear off one of the plurality of segments of the paper-based substrate on which the matrix is disposed. Further, each segment has dimensions of length, width, and thickness such that when separated, the segment fits the user's gum.

[0034] The present invention also includes a method of manufacturing an active ingredient delivery system. The method may include preparing a paper-based substrate and, in some embodiments, disposing a matrix on the paper-based substrate via printing, the matrix including an active ingredient element and a carrier. In one embodiment of the disclosed method, the step of disposing the matrix on the paper-based substrate is achieved via printing. In one aspect of such an embodiment, refilling of the matrix onto the substrate is achieved using a metering pump during each printing run. The method may further include sizing the paper-based substrate on which the matrix is disposed to dimensions of length, width, and thickness such that the paper-based substrate fits the user's gums.

[0035] In alternative embodiments, the method may include preparing a paper-based substrate and disposing a matrix on the paper-based substrate. In one embodiment, the matrix includes an active ingredient element and at least one carrier. Further, the matrix may include at least one of a flavor element, a softening agent, a viscosity modifier, an additional carrier, and a sweetener. In a preferred embodiment of the disclosed method, the step of disposing the matrix on the paper-based substrate may be achieved via screen printing. In one aspect of such an embodiment, refilling of the matrix onto the substrate may be achieved using a metering pump during each screen printing run. The method may further include perforating the paper-based substrate such that segments such as strip pieces are connected and separated via the perforations. The segments may have dimensions of length, width, and thickness such that each segment that absorbs or releases the active ingredient element fits the user's gums.

[0036] substrate In certain embodiments, the substrate is a paper-based product that can be made on a standard or modified paper-making machine. In certain embodiments, the substrate comprises cellulose pulp. Cellulose pulp is an absorbent organic fiber that sufficiently retains the liquid applied in this application. In certain preferred embodiments, the substrate comprises cellulose pulp and cotton fibers, such as cotton linter. Cotton fibers are soft and can improve the comfort of the user inserting the active ingredient delivery system into the mouth.

[0037] In certain embodiments, the substrate may be composed of additional materials common to paper-based products in addition to or instead of the above materials. Generally, absorbent materials are useful in the substrates described in this disclosure. For example, fibers that are not soluble but biodegradable and have excellent absorbency, such as modal fibers, viscose, wool, lyocell, and ioncell, can be used. Furthermore, different types of cotton fibers, i.e., modified cellulose or cotton fibers, can also be used. Generally, the substrate must be composed of a material having sufficient structural and chemical integrity to place a matrix thereon.

[0038] In certain embodiments, the substrate carries a safe and effective dose of the active ingredient element and is sized to fit comfortably in the user's mouth, on the user's gums, or between the gums and cheek tissue, without being prominently visible as a protrusion on the user's face and without being visible to a third party. Thus, the thickness of the substrate is such that the overall thickness of the active ingredient delivery system is thinner compared to a white pouch product or a snus. The active ingredient delivery system is further simplified for storage and transport. The thickness of the substrate is also important for the ability to carry the disposed matrix. If the substrate is too thin, it will not properly support or contain the active ingredient elements of the matrix. If the substrate is too thick or otherwise too large, it will not fit comfortably in the user's mouth, on the user's gums, or between the gums and cheek tissue. Further, if the substrate is too thick or too large or too thin, it will not properly absorb, retain, and / or release the liquid of the matrix disposed thereon to the user. Generally, the paper forming the pouch of a white pouch product is too thin to function as the paper-based substrate disclosed herein.

[0039] In an embodiment, the dimensions of the active ingredient delivery system are substantially determined by the dimensions of the substrate. In a preferred embodiment, the active ingredient delivery system substantially forms a rectangular parallelepiped having rectangular or rounded edges and corners, having a length, a width, and a thickness (also referred to herein as thickness). In a preferred embodiment, the length is at least 5 mm, more preferably at least 10 mm, more preferably at least 15 mm, more preferably at least 18 mm, more preferably at least 21 mm, more preferably at least 24 mm, and at most 75 mm, more preferably at most 60 mm, more preferably at most 50 mm, more preferably at most 35 mm, more preferably at most 32 mm, more preferably at most 29 mm, more preferably at most 26 mm. In the above embodiment, the width is at least 3 mm, more preferably at least 4 mm, more preferably at least 5 mm, more preferably at least 7 mm, more preferably at least 9 mm, and at most 20 mm, more preferably at most 17 mm, more preferably at most 15 mm, more preferably at most 13 mm, more preferably at most 11 mm, more preferably at most 8 mm. In the above embodiment, the thickness is at least 0.2 mm, more preferably at least 0.3 mm, more preferably at least 0.5 mm, more preferably at least 0.7 mm, more preferably at least 1.0 mm, more preferably at least 1.2 mm, and at most 3.0 mm, more preferably at most 2.7 mm, more preferably at most 2.3 mm, more preferably at most 2.1 mm, more preferably at most 2.0 mm, more preferably at most 1.5 mm.

[0040] Further, as shown in FIG. 1, the substrate may be perforated so that the user can tear off an individual dose of the active ingredient delivery system.

[0041] Matrix The matrix can contain active ingredient elements and may further contain flavor elements and / or additional elements. In an active ingredient delivery system, the matrix may be disposed on a substrate as a single mixture, or different components of the matrix, or mixtures thereof, may be disposed as separate mixtures, each simultaneously or at different times.

[0042] In embodiments, the active ingredient elements can be absorbed or released by the user. Examples of active ingredient elements can include nicotine, CBD, THC, caffeine, ibuprofen, pharmaceuticals, vitamins, glucose, or other natural or synthetic sugars, other substances, and mixtures thereof.

[0043] In certain embodiments, the matrix further includes at least one carrier. The carrier can be any solvent, fluid or vehicle that is safe for human ingestion / absorption. The carrier is selected such that the carrier is compatible with the active ingredient elements and the active ingredient elements are miscible or dispersible in the carrier. In certain embodiments, the carrier can be water, ethanol, propylene glycol, etc., or mixtures thereof. In a preferred embodiment, propylene glycol is mentioned as a carrier.

[0044] In certain embodiments, the active ingredient elements are present in the matrix in an amount sufficient to enable an effective dose to be delivered through absorption etc. through the user's gums from the active ingredient delivery system. One of ordinary skill in the art will understand that changing the volume, purity and concentration of the active ingredient elements used in the active ingredient delivery system will affect the effectiveness and strength of the delivered dose.

[0045] In some embodiments, the active ingredient element may be present in the matrix in an amount of 0.02% to 30% by weight of the matrix, in a further embodiment 0.2% to 15% by weight of the matrix, in a further embodiment 0.5% to 8% by weight of the matrix, in a further embodiment 0.5% to 3% by weight of the matrix, and in yet a further embodiment 1% to 2% by weight of the matrix. These embodiments are particularly beneficial when nicotine is the active ingredient element.

[0046] In some embodiments, the matrix may contain a flavor element in an amount of 0.05% to 20% by weight as a percentage of the weight of the matrix, in a further embodiment 0.2% to 18% by weight as a percentage of the weight of the matrix, in a further embodiment 0.5% to 10% by weight, in a further embodiment 1% to 7% by weight, in a further embodiment 1.5% to 5% by weight, and in yet a further embodiment 1.8% to 3% by weight.

[0047] In some embodiments, the matrix may contain a softening agent such as glycerin. In some embodiments, a carrier, flavor carrier, or additional carrier balances the weight of the matrix.

[0048] In a particular preferred embodiment, the active ingredient element is nicotine and is present in the matrix in a solution containing a carrier, and the solution of nicotine and carrier is present in the matrix in an amount of 1.5% to 30% by weight based on the weight of the matrix. In a further preferred embodiment, the nicotine-carrier solution constitutes 4% to 20%, 5% to 15%, or 6% to 10% by weight as a percentage of the weight of the matrix. In a preferred embodiment, the carrier may be propylene glycol.

[0049] In a particular embodiment, the active ingredient element may be liquid nicotine, nicotine oil, crystalline nicotine, a nicotine salt, or a mixture thereof.

[0050] In certain embodiments where the active ingredient element is nicotine, each portion of the substrate intended to provide an individual dose contains from about 1 mg to 30 mg of nicotine. For example, one portion of the substrate can contain 1 mg of nicotine, alternatively 4 mg of nicotine, alternatively 8 mg of nicotine, alternatively 10 mg of nicotine, or yet alternatively 12 mg of nicotine. In certain preferred embodiments, propylene glycol is used as a carrier for the active ingredient element.

[0051] In certain embodiments, the flavor element can be any food-approved compound having a flavor. In certain embodiments, the flavor element is wintergreen, spearmint, cool mint, peppermint, citrus, cinnamon, coffee, licorice, lime, bergamot, menthol, vanilla, blueberry, raspberry, synthetic compounds used to mimic these flavors, or mixtures thereof. In preferred embodiments, the flavor element is incorporated into a flavor carrier fluid or flavor carrier that can also form part of the matrix. The flavor carrier fluid is selected such that the flavor element is miscible or dispersible in the flavor carrier fluid. Exemplary suitable flavor carriers include water, propylene glycol, ethanol, mixtures thereof, and the like. The flavor carrier can be the same as or different from any carrier compatible with the active ingredient element. In embodiments, the flavor element may be prepared as a mixture with the active ingredient element, or the flavor element may be part of a mixture prepared separately from the active ingredient element.

[0052] In certain embodiments, the matrix comprises the active ingredient element and, optionally, one or more of a flavor element, a softening agent, a viscosity modifier, an additional carrier, and / or a sweetener.

[0053] The matrix can supply a softening agent that, for example, improves or maintains the texture of the substrate on which the matrix is disposed, and preferably aids the user experience. The softening agent can improve the texture by reducing or eliminating mucosal irritation by the active ingredient delivery system. The softening agent can also help in the processing of the substrate when applying the matrix to the substrate by making the substrate more flexible. In embodiments, the matrix comprises up to 80% by weight, more preferably up to 60% by weight, more preferably up to 50% by weight, more preferably up to 45% by weight, and still more preferably up to 40% by weight of the softening agent. In embodiments, the matrix comprises at least 2% by weight of the softening agent, more preferably at least 5% by weight of the softening agent, more preferably at least 12% by weight of the softening agent, more preferably at least 15% by weight of the softening agent, and still more preferably at least 18% by weight of the softening agent. One suitable softening agent is glycerin. In preferred embodiments, food grade glycerin is applied. In alternative embodiments, glycerin, diethylene glycol, propylene glycol, ceramides, natural oils and butters such as shea butter, jojoba oil, cocoa butter or avocado oil, or mixtures thereof can also be used.

[0054] The matrix can supply a viscosity modifier that can be used to adjust the viscosity of the matrix to suit different application means to the substrate. The viscosity can be adjusted by using a number of different materials. One of ordinary skill in the art will be able to select a viscosity modifier or rheology modifier to achieve various viscosities or rheology profiles of the matrix. According to one embodiment, the viscosity modifier can be a silicate compound or propylene glycol.

[0055] The matrix can be supplied with additional carriers. The additional carriers may be the same as or different from any carriers used with the active ingredient elements or any flavor carriers used with any flavor elements. The additional carriers can further be selected to enable homogenization or formation of a solution or dispersion by the elements of the matrix. Exemplary additional carriers include water, ethanol, propylene glycol, mixtures thereof, and the like.

[0056] The matrix can be supplied with sweeteners to enhance the flavor of the active ingredient delivery system to the user. Any food-grade sweetener is contemplated, including, for example, sugar, cane, honey, aloe vera, high fructose corn syrup, allulose, maltitol, aspartame, syrup, saccharin, sorbitol, stevia, sucralose, and xylitol.

[0057] By selecting the various elements of the matrix in various amounts and adjusting by the selection of the amount or elements, the release rate of the active ingredient elements from the active ingredient delivery system can be controlled to obtain the desired effectiveness or strength as a result of the delivery rate through the user's gums or cheek.

[0058] Active ingredient delivery system In embodiments, the active ingredient delivery system comprises a matrix disposed on a substrate. In preferred embodiments, the matrix includes an active ingredient element, a carrier element, and one or more of a flavor element, a softening agent, a viscosity modifier, an additional carrier, and a sweetener. In certain embodiments, the active ingredient delivery system has a moisture content greater than 20%, preferably greater than 25%, more preferably greater than 30%, even more preferably greater than 35%, still more preferably 35% - 75%, more preferably 40% - 52%, or 44% - 50%.

[0059] In some embodiments, the softening agent may be administered separately on the substrate or in addition to its incorporation through the matrix. In certain embodiments, the softening agent is administered to the substrate before applying a matrix having an active ingredient element onto the substrate. The softening agent may be thus administered onto the substrate by dipping, printing, or any conventional method for administering liquid to a paper-based substrate.

[0060] In certain preferred embodiments, the matrix is printed onto the substrate less than 10 times, more preferably less than 7 times, more preferably 5 times or less, more preferably 4 times or less, and more preferably 3 times or less. In certain preferred embodiments, the matrix is printed onto the substrate at least once, in a further embodiment at least twice, and in still a further embodiment at least three times. Considering the content of the present disclosure, those skilled in the art will recognize that increasing the concentration of the active ingredient element in the matrix may reduce the number of printing runs required to achieve a certain total amount of the active ingredient element in the active ingredient delivery system. Those skilled in the art will recognize the benefits in the form of reduced processing time and reduced processing cost due to the reduced number of printing runs. However, a low number of printing runs may also reduce the moisture content in the active ingredient delivery system, and as a result, among other effects, may lead to an undesirable texture. In embodiments where a higher concentration of the active ingredient element is used and a lower number of printing runs is used, the matrix may further include a softening agent to improve the texture. One preferred such softening agent is glycerin as discussed above. Those skilled in the art, benefiting from the present disclosure, will be able to balance the concentration of the active ingredient element and the concentration of any glycerin to optimize the number of printing runs required and the texture appropriate for the user.

[0061] In certain embodiments, the matrix is disposed on the substrate so as to substantially cover the entire substrate. In certain other embodiments, the matrix is applied so as to cover only a part of the substrate.

[0062] Figure 1 shows an exemplary active ingredient delivery system 10 in which a matrix is screen printed on a first surface 25 of a substrate 12. The matrix may also be printed on an opposing second surface 26 of the substrate 12. In the exemplary active ingredient delivery system of Figure 1, the active ingredient delivery system has a perforation 24 and comprises ten segments or strip pieces separated by the perforation 24, such as segments 20', 20'', and 20'''. The perforation 24 that separates the segments 20 allows the user to easily tear off the portion that provides an individual dose of the active ingredient element.

[0063] In other embodiments, the active ingredient delivery system does not have perforations. For example, the segments may be divided into individual dose portions. The active ingredient delivery system may have a variety of regular or irregular shapes that fit onto the gums in the user's mouth. If such a shape has an edge or a corner, the edge or the corner may be rounded, square, or have a different suitable configuration.

[0064] Figure 2 shows an embodiment of a segment or strip piece 20 of the active ingredient delivery system of the present invention. The segment may comprise a first side surface 31, a second opposing side surface 32, a first end 33, and a second opposing end 34. In addition, the segment 20 may comprise a second surface 26 that opposes the first surface 25. As shown in Figures 1 and 2, the segment is sized to fit onto the user's gums and has dimensions of length 21, width 23, and thickness 22.

[0065] The present disclosure also includes a method of manufacturing an active ingredient delivery system. The method may include the steps of providing a paper-based substrate and disposing a matrix on the paper-based substrate, preferably by printing, wherein the matrix contains at least an active ingredient element. The active ingredient element provided by the method may further be incorporated into a carrier. The matrix may further optionally contain one or more of a flavor element, a softening agent, a viscosity modifier, an additional carrier, and a sweetener.

[0066] In certain specific embodiments, the matrix provided by the present method may have the characteristics of the active ingredient delivery system described in this disclosure.

[0067] In a preferred embodiment of the present method, the matrix is printed directly onto the substrate.

[0068] Suitable printing techniques include screen printing technology, flexographic printing technology, inkjet / digital printing technology, tampon printing technology, gravure printing, letterpress printing, rotary printing, 3D printing, offset printing, spray formulations, or improved versions of these techniques.

[0069] In a preferred embodiment, the step of printing the matrix onto a paper-based substrate is achieved by screen printing.

[0070] In the present disclosure, the screen printing technique refers to a printing technique in which a printing mixture is dispensed onto a product through a screen. Screen printing is generally also called silk screen printing because the threads of the mesh originally used in screen printing were made of silk fibers. In principle, the present disclosure contemplates various screen printing techniques including the use of manual and semi-automatic techniques, as well as the use of an automated line with a screen and a printable product moving thereon. The conditions of screen printing can be changed as needed. For example, the screen density can be adjusted to control the amount of the matrix, and thereby control the amount of the active ingredient element and any flavoring element printed on the substrate and included in the active ingredient delivery system. When the screen density is high, the transfer rate of the matrix is slower than that of a coarser sieve, and accordingly, the amount of the active ingredient element on the printed substrate also changes according to the screen density.

[0071] In certain embodiments, between each print run, matrix or other liquid is refilled onto the substrate to replenish liquid lost to the screen. In preferred embodiments, an electronics industry grade metering pump is used to refill the liquid at least once during the print run.

[0072] Accordingly, administration of the active ingredient elements in the active ingredient delivery system is accurate, easy, and simple. For example, it is easy to dispense a sufficient amount of the active ingredient elements to the user by adjusting the amount of matrix delivered to the substrate of a given active ingredient delivery system. Further, since screen printing can deliver a specific amount of active ingredient elements more accurately through the matrix with a tighter tolerance than other methods such as spraying or dipping, the active ingredient delivery systems of the present disclosure can achieve more dosages than are allowed under the regulatory laws of a particular jurisdiction for a given active ingredient.

[0073] Compared to known techniques, the disclosed active ingredient delivery systems have the particular advantage of easily and accurately controlling the distribution of the active ingredient elements and any other matrix elements (such as flavor elements) on the substrate.

[0074] The various elements of the systems of the present invention can be composed of any number of materials, and steps can be added to the disclosed methods as will be recognized by those skilled in the art in view of the present disclosure. Additional materials and variations in the methods of applying the matrix and printing methods are described in U.S. Patent Application Publication Nos. 2016 / 0137858 and 2014 / 0349044, which are hereby incorporated by reference in their entirety and are equally applicable in view of the present disclosure. [Item 1] A paper-based substrate, A matrix comprising an active ingredient element and a carrier, An active ingredient delivery system comprising: The matrix is disposed on the paper-based substrate, The paper-based substrate has dimensions of length, width, and thickness such that the paper-based substrate on which the matrix is disposed fits the user's gum. An active ingredient delivery system. [Item 2] The active ingredient delivery system according to Item 1, wherein the matrix further contains a softening agent. [Item 3] The active ingredient delivery system according to Item 2, wherein the softening agent is food-grade glycerin. [Item 4] The active ingredient delivery system according to Item 3, wherein the glycerin is present in an amount of 2 wt% to 60 wt% as a percentage of the weight of the matrix. [Item 5] The active ingredient delivery system according to Item 3, wherein the glycerin is present in an amount of 15 wt% to 45 wt% as a percentage of the weight of the matrix. [Item 6] The active ingredient delivery system according to Item 1, wherein the paper-based substrate contains cellulose pulp and cotton linter. [Item 7] The active ingredient delivery system according to Item 6, wherein the paper-based substrate contains at least about 40 wt% cellulose pulp of the base substrate and at least about 30 wt% cotton linter of the paper-based substrate. [Item 8] The active ingredient delivery system according to Item 6, wherein the paper-based substrate contains at most about 70 wt% cellulose pulp of the paper-based substrate and at most about 60 wt% cotton linter of the paper-based substrate. [Item 9] The active ingredient delivery system according to Item 6, wherein the paper-based substrate contains about 50 wt% to about 60 wt% cellulose pulp of the paper-based substrate. [Item 10] The active ingredient delivery system according to Item 6, wherein the paper-based substrate contains about 40 wt% to about 50 wt% cotton linter of the paper-based substrate. [Item 11] The active ingredient delivery system according to Item 6, wherein the paper-based substrate substantially does not contain viscose fibers. [Item 12] The active ingredient delivery system according to Item 1, wherein the paper-based substrate has a length of about 10 mm to about 50 mm, a width of about 3 mm to about 15 mm, and a thickness of about 0.2 mm to about 2.0 mm. [Item 13] The active ingredient delivery system according to Item 1, wherein the active ingredient element is selected from nicotine, caffeine, THC, CBD, vitamins, ibuprofen or pharmaceuticals, or mixtures thereof. [Item 14] The active ingredient delivery system according to claim 13, wherein the active ingredient element is selected from nicotine, THC, or CBD, vitamins, glucose, or a mixture thereof. [Claim 15] The active ingredient delivery system according to claim 13, wherein the active ingredient element is nicotine. [Claim 16] The active ingredient delivery system according to claim 15, wherein the active ingredient element constitutes about 0.02% to about 30% by weight of the matrix. [Claim 17] The active ingredient delivery system according to claim 1, wherein the active ingredient element is dissolved or dispersed in the carrier before being placed on the substrate. [Claim 18] The active ingredient delivery system according to claim 1, wherein the carrier contains propylene glycol. [Claim 19] The active ingredient delivery system according to claim 1, wherein the matrix further contains a flavor element. [Claim 20] The active ingredient delivery system according to claim 19, further comprising a flavor carrier, wherein the flavor element is dissolved or dispersed in the flavor carrier before being placed on the substrate. [Claim 21] The active ingredient delivery system according to claim 20, wherein the flavor carrier contains propylene glycol. [Claim 22] The active ingredient delivery system according to claim 19, wherein the matrix contains about 0.2% to about 15% by weight of the flavor element and about 0.02% to about 30% by weight of the active ingredient element as a percentage of the total weight of the matrix. [Claim 23] The active ingredient delivery system according to claim 1, wherein the matrix is placed on the substrate by directly printing the matrix on the substrate. [Claim 24] The active ingredient delivery system according to claim 1, wherein the matrix is placed on the substrate via screen printing. [Claim 25] The active ingredient delivery system according to claim 1, wherein the moisture content of the active ingredient delivery system is greater than about 20%. [Claim 26] The active ingredient delivery system according to claim 1, wherein the moisture content of the active ingredient delivery system is 35% to 75%. [Claim 27] The active ingredient delivery system according to claim 1, further comprising a plurality of paper-based substrates, wherein the matrix is placed on each paper-based substrate, and the plurality of paper-based substrates are connected to form a sheet, and a user can easily tear a portion to provide an individual dose of the active ingredient element. [Claim 28] The active ingredient delivery system according to claim 27, wherein the plurality of paper-based substrates are connected via perforations. [Claim 29] The active ingredient delivery system according to claim 1, wherein the paper-based substrate on which the matrix is disposed is sized to fit on the user's gums without forming protrusions visible to the user's face. [Claim 30] The active ingredient delivery system according to claim 1, wherein the matrix further contains a sweetener. [Claim 31] The active ingredient delivery system according to claim 1, further comprising a softening agent, a flavoring element, and a sweetener, wherein the carrier, the softening agent, the flavoring element, and the sweetener are food-grade. [Claim 32] A paper-based substrate comprising a plurality of connected segments, A matrix comprising an active ingredient element and a carrier, An active ingredient delivery system comprising: The matrix is disposed on the paper-based substrate, The plurality of connected segments are connected such that a user can easily separate one of the plurality of connected segments of the paper-based substrate on which the matrix is disposed, The active ingredient delivery system, wherein each of the plurality of connected segments has dimensions of length, width, and thickness such that each segment fits on the user's gums. [Claim 33] The active ingredient delivery system according to claim 32, wherein the plurality of connected segments are connected via perforations. [Claim 34] The active ingredient delivery system according to claim 32, further comprising a flavoring element and a softening agent. [Claim 35] The active ingredient delivery system according to claim 34, wherein the carrier, the softening agent, and the flavoring element are food-grade. [Claim 36] The matrix according to claim 32, wherein the matrix contains a first liquid mixture and a second liquid mixture, the first liquid mixture contains the active ingredient element and the carrier, the second liquid mixture contains the flavoring element, the softening agent, and the carrier, and the first liquid mixture and the second liquid mixture are separately disposed on the paper-based substrate. [Claim 37] The active ingredient delivery system according to claim 32, wherein the plurality of connected segments are separated. [Claim 38] A method of manufacturing an active ingredient delivery system, Preparing a paper-based substrate, Disposing a matrix on the paper-based substrate, the matrix containing an active ingredient element and a carrier. Adjusting the paper-based substrate on which the matrix is disposed to a size having dimensions of length, width, and thickness such that the paper-based substrate fits the user's gums; A method comprising. [Item 39] The method according to item 38, wherein the active ingredient element is dissolved or dispersed in the carrier. [Item 40] The method according to item 38, wherein the matrix further comprises a softening agent. [Item 41] The method according to item 38, wherein the matrix further comprises a flavor element. [Item 42] The method according to item 38, wherein the carrier comprises propylene glycol. [Item 43] The method according to item 41, wherein the matrix further comprises a flavor carrier and the flavor element is dissolved or dispersed in the flavor carrier. [Item 44] The method according to item 38, wherein the step of disposing the matrix on the paper-based substrate is achieved by directly printing the matrix on the substrate. [Item 45] The method according to item 38, wherein the step of disposing the matrix on the paper-based substrate is achieved by screen printing. [Item 46] The method according to item 45, wherein the screen printing further comprises refilling the substrate with liquid while performing the screen printing through at least two metering pumps provided to distribute the matrix on the substrate. [Item 47] A method of manufacturing an active ingredient delivery system, comprising: Preparing a paper-based substrate comprising a plurality of connected segments; Disposing a matrix on the paper-based substrate, the matrix comprising an active ingredient element and a carrier; Adjusting the size of one of the plurality of connected segments of the paper-based substrate on which the matrix is disposed so that the user can easily detach it, each segment of the plurality of connected segments having dimensions of length, width, and thickness such that each segment fits the user's gums; A method comprising. [Item 48] The method according to item 47, wherein the plurality of connected segments are connected via perforations.

Example

[0075] Example 1 In an exemplary embodiment of the present invention, an absorbent substrate having a thickness of 1.9 mm and composed of cellulose pulp (50% to 60% by weight of the substrate) and cotton linter (40% to 50% by weight of the substrate) can be supplied to a high-speed screen printing machine (Sakurai brand, Sakurai Graphic System Corp. (Hounslow, Middlesex, UK)) by a sheet feeder (commonly used in the graphic industry). The delivery of the printing fluid (matrix) can be optimized using the mesh of the screen printing machine, preferably the 063-063 line. The nicotine active ingredient element may be incorporated into a mixture containing 10% by weight of nicotine (available from Nicobrand (189 Castleroe Road, Coleraine, Co. Londonderry, BT51 3RP, UK)) and the balance propylene glycol carrier. The mixture of active ingredient elements may be pressed onto the substrate the number of times necessary to achieve the desired nicotine content in the printed substrate (e.g., 3 runs). Approximately 2% by weight of a flavor element and approximately 30% by weight of a softening agent, such as food grade glycerin (each available from Hertz Flavors GmbH & Co. KG), may be incorporated into a second mixture. The flavor element may be formed from food grade edible flavors and sweeteners in solution. The balance of the second mixture may contain a propylene glycol carrier. The second mixture may be pressed onto the substrate the number of times necessary to achieve the desired moisture content of the product, taking into account the amount of the mixture of active ingredient elements added (e.g., 3 runs). In this example, the desired moisture content may be 40% by weight. After printing, the substrate printed with the matrix may be cut into the desired shape according to the desired nicotine content at each dose using a die cutter (available from Bobst Group SA (Mex, Switzerland)). The substrate printed with the matrix and cut may be further perforated so that the user can easily tear off a piece of the substrate printed with the matrix containing an appropriate amount of nicotine for one use.

[0076] In this embodiment, it is preferred to mix all liquid components at room temperature. Standard and generally available instruments can be used for mixing. Mechanical mixing is not necessary for mixing. The manufacturing process can be carried out at room temperature. The liquid raw materials used preferably do not evaporate at room temperature, and thus there is no need to enhance ventilation.

[0077] Detailed embodiments of the present invention are disclosed herein. However, although various embodiments and examples of the present invention have been described above, these descriptions are given for illustrative and explanatory purposes and are not limiting. Modifications, alterations, changes, and departures from the systems and methods disclosed above can be adopted without departing from the spirit and scope of the present invention. Moreover, the specific structural and functional details disclosed herein are not to be construed as limiting, but rather as a representative basis for the claims and for teaching those skilled in the art how to use the present invention in various ways. It will be apparent to those skilled in the art that many changes and substitutions can be made to the foregoing description of the preferred embodiments and examples without departing from the spirit and scope of the present invention as defined by the appended claims.

[0078] In the appended claims, references to elements in the singular are not intended to mean "only one" unless explicitly stated otherwise, but rather are intended to mean "one or more." All elements that are structurally and functionally equivalent to the elements of the above-described embodiments, whether known to those skilled in the art or later become known, are hereby incorporated by reference and are intended to be included within the scope of the claims. Moreover, a device need not address each and every problem sought to be solved by the present invention in order to be within the scope of the claims. Further, components, elements, or combinations thereof in the present disclosure are not intended to be publicly available whether or not the components, elements, or method steps are explicitly recited in the claims. No claim element herein shall be construed under 35 U.S.C. § 112, paragraph 6, unless the element is explicitly recited using the phrase "means for." Absent a clear definition in this specification, terms of all claims shall be given all ordinary and customary meanings that are not inconsistent with the specification and prosecution history of the application.

[0079] Furthermore, the purpose of the abstract is to enable various patent offices and the general public, especially scientists, engineers, and practitioners in the art who are not familiar with the terminology or expressions of patents or laws, to quickly determine from a cursory review the nature and essence of the technical disclosure of the application. The abstract is not intended to limit the scope of the invention in any way.

Claims

1. A paper-based substrate containing fibers that are biodegradable rather than soluble, and A matrix comprising an active ingredient element, a carrier, a flavor element, and a softening agent, An active ingredient delivery system comprising: The matrix is printed on the paper-based substrate, The paper-based substrate has dimensions of length, width, and thickness such that the paper-based substrate on which the matrix is printed fits the user's gums, The matrix contains a first liquid mixture and a second liquid mixture, the first liquid mixture contains the active ingredient element and the carrier, the second liquid mixture contains the flavor element, the softening agent, and the carrier, and the first liquid mixture and the second liquid mixture are printed separately on the paper-based substrate, Active ingredient delivery system.

2. The active ingredient delivery system according to claim 1, wherein the softening agent is food-grade glycerin.

3. The active ingredient delivery system according to claim 2, wherein the glycerin is present in an amount of 2% to 60% by weight as a percentage of the weight of the matrix.

4. The active ingredient delivery system according to claim 2, wherein the glycerin is present in an amount of 15% to 45% by weight as a percentage of the weight of the matrix.

5. The active ingredient delivery system according to claim 1, wherein the paper-based substrate contains cellulose pulp and cotton linter.

6. The active ingredient delivery system according to claim 5, wherein the paper-based substrate contains at least about 40% by weight of cellulose pulp and at least about 30% by weight of cotton linter of the paper-based substrate.

7. The active ingredient delivery system according to claim 5, wherein the paper-based substrate contains at most about 70% by weight of cellulose pulp and at most about 60% by weight of cotton linter of the paper-based substrate.

8. The active ingredient delivery system according to claim 5, wherein the paper-based substrate contains about 50% to about 60% by weight of cellulose pulp of the paper-based substrate.

9. The active ingredient delivery system according to claim 5, wherein the paper-based substrate contains about 40% to about 50% by weight of cotton linter of the paper-based substrate.

10. The active ingredient delivery system according to claim 5, wherein the paper-based substrate is substantially free of viscose fibers.

11. The active ingredient delivery system according to claim 1, wherein the paper-based substrate has a length of about 10 mm to about 50 mm, a width of about 3 mm to about 15 mm, and a thickness of about 0.2 mm to about 2.0 mm.

12. The active ingredient delivery system according to claim 1, wherein the active ingredient element is selected from nicotine, caffeine, THC, CBD, vitamins, ibuprofen and pharmaceuticals, and mixtures thereof.

13. The active ingredient delivery system according to claim 1, wherein the active ingredient element is selected from nicotine, THC, and CBD, vitamins, glucose, and mixtures thereof.

14. The active ingredient delivery system according to claim 12, wherein the active ingredient element is nicotine.

15. The active ingredient delivery system according to claim 14, wherein the active ingredient element constitutes about 0.02% to about 30% by weight of the matrix.

16. The active ingredient delivery system according to claim 1, wherein the active ingredient element is dissolved or dispersed in the carrier before being printed on the substrate.

17. The active ingredient delivery system according to claim 1, wherein the carrier contains propylene glycol.

18. The active ingredient delivery system according to claim 1, further comprising a flavor carrier, wherein the flavor element is dissolved or dispersed in the flavor carrier before being printed on the substrate.

19. The active ingredient delivery system according to claim 18, wherein the flavor carrier contains propylene glycol.

20. The active ingredient delivery system according to claim 1, wherein the matrix contains about 0.2% to about 15% by weight of the flavor element and about 0.02% to about 30% by weight of the active ingredient element as a percentage of the total weight of the matrix.

21. The active ingredient delivery system according to claim 1, wherein the matrix is printed on the substrate via screen printing.

22. The active ingredient delivery system according to claim 1, wherein the water content of the active ingredient delivery system is greater than about 20%.

23. The active ingredient delivery system according to claim 1, wherein the water content of the active ingredient delivery system is 35% to 75%.

24. The active ingredient delivery system according to claim 1, further comprising a plurality of paper-based substrates, wherein the matrix is printed on each paper-based substrate, and the plurality of paper-based substrates are connected so as to form a sheet, and a user can easily tear a portion to provide the individual dosage of the active ingredient element.

25. The active ingredient delivery system according to claim 24, wherein the plurality of paper-based substrates are connected via perforations.

26. The active ingredient delivery system according to claim 1, wherein the paper-based substrate on which the matrix is printed is sized to fit the user's gums without forming protrusions visible to the user's face.

27. The active ingredient delivery system according to claim 1, wherein the matrix further contains a sweetener.

28. The active ingredient delivery system according to claim 1, further comprising a sweetener, wherein the carrier, the softening agent, the flavor element and the sweetener are of food grade.

29. A paper-based substrate including a plurality of connected segments and fibers that are biodegradable rather than soluble, A matrix including an active ingredient element, a carrier, a flavor element, and a softening agent, An active ingredient delivery system comprising: The matrix is printed on the paper-based substrate, Among the plurality of connected segments of the paper-based substrate on which the matrix is printed, one of the plurality of connected segments is connected so that a user can easily separate it, Each segment of the plurality of connected segments has dimensions of length, width, and thickness such that each segment fits the user's gums, The matrix includes a first liquid mixture and a second liquid mixture, the first liquid mixture includes the active ingredient element and the carrier, the second liquid mixture includes the flavor element, the softening agent, and the carrier, and the first liquid mixture and the second liquid mixture are printed separately on the paper-based substrate. Active ingredient delivery system.

30. The active ingredient delivery system according to claim 29, wherein the plurality of connected segments are connected via perforations.

31. The active ingredient delivery system according to claim 29, wherein the carrier, the softening agent, and the flavor element are of food grade.

32. A method for manufacturing an active ingredient delivery system, comprising: preparing a paper-based substrate that is biodegradable rather than soluble; printing a matrix on the paper-based substrate, the matrix comprising an active ingredient element, a carrier, a flavor element, and a softening agent; adjusting the paper-based substrate printed with the matrix to a size having dimensions of length, width, and thickness such that the paper-based substrate fits the user's gum. The method, wherein the matrix comprises a first liquid mixture and a second liquid mixture, the first liquid mixture comprises the active ingredient element and the carrier, the second liquid mixture comprises the flavor element, the softening agent, and the carrier, and the first liquid mixture and the second liquid mixture are printed separately on the paper-based substrate.

33. The method according to claim 32, wherein the active ingredient element is dissolved or dispersed in the carrier.

34. The method according to claim 32, wherein the carrier comprises propylene glycol.

35. The method according to claim 32, wherein the matrix further comprises a flavor carrier, and the flavor element is dissolved or dispersed in the flavor carrier.

36. The method according to claim 32, wherein the step of printing the matrix on the paper-based substrate is achieved by screen printing.

37. A method for manufacturing an active ingredient delivery system, comprising: preparing a paper-based substrate containing fibers that are biodegradable rather than soluble; printing a matrix on the paper-based substrate, the matrix comprising an active ingredient element and a carrier; adjusting the paper-based substrate printed with the matrix to a size having dimensions of length, width, and thickness such that the paper-based substrate fits the user's gum. The method, wherein the step of printing the matrix on the paper-based substrate is achieved by screen printing, and the screen printing further comprises refilling a liquid onto the substrate while performing screen printing through at least two metering pumps provided to distribute the matrix on the substrate.

38. A method for manufacturing an active ingredient delivery system, comprising: Preparing a paper-based substrate comprising a plurality of connected segments and fibers that are biodegradable rather than soluble; Printing a matrix on the paper-based substrate, wherein the matrix comprises an active ingredient element and a carrier; Adjusting the size of one of the plurality of connected segments of the paper-based substrate on which the matrix is printed so that the user can easily separate it, wherein each segment of the plurality of connected segments has dimensions of length, width, and thickness such that each segment fits the user's gum; A method comprising: The step of printing the matrix on the paper-based substrate is achieved by screen printing, and the screen printing further comprises refilling the substrate with liquid while performing screen printing through at least two metering pumps provided to distribute the matrix on the substrate.

39. The method according to claim 38, wherein the plurality of connected segments are connected via perforations.

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