Colon cleansing system with self-cleaning characteristics

Abstract

To provide systems and methods for cleaning a colon or other portion of an intestine.SOLUTION: The invention includes optional use of sensors 204 to detect conditions of blockage of a flow of materials within an evacuation channel 203 used to remove fecal material from the body. The invention also includes devices and methods for purging such blockages from the evacuation channel.SELECTED DRAWING: Figure 4A

Description

Technical Field

[0001] In some embodiments, the present invention relates to a system for cleaning the colon and other body lumens, and more specifically, but not limited to, a cleaning system and method having automated self-cleaning characteristics.

Background Art

[0002] Current gastrointestinal techniques include methods for cleaning various fecal substances from the colon. In the case of fecal matter due to long-term constipation, the cleaning of the colon itself can be the purpose of the method. In other cases, colon cleaning is necessary or desired to examine the colon cells without being blocked, and / or to facilitate diagnostic tests and / or treatment of such cells.

[0003] A colonoscope provides means for optically and / or electronically imaging the colon and its contents. In some methods for observing the colon, imaging is performed while washing or cleaning a part of the colon with a perfusion fluid. The perfusion fluid, fecal matter, and / or other colon contents are removed from the colon by suction and / or other means for discharging substances from the body.

[0004] In some cases, perfusion into the colon is performed through the working channel of the colonoscope. In some cases, fecal matter is carried from the body through the working channel of the colonoscope. In some cases, a perfusion channel and / or a suction channel can be connected to the colonoscope for collaborative use of the cleaning system and the colonoscope. A cleaning system having the property of purifying generation obstacles that block the discharge flow and cause problems is known in the art. ​

[0005] Note that the following patent documents, namely, U.S. Patent Application Publication No. 2010 / 0185056 by Tal Gordon et al., U.S. Patent Application Publication No. 201 1 / 0105845 by Tal Gordon et al., and U.S. Patent Application Publication No. 20 12 / 0101336 by Yoav Hirsch et al. relate to the technical field of the present application.

Summary of the Invention

[0006] According to one aspect of some embodiments of the present invention, a system for washing the intestine, comprising a discharge lumen for discharging perfusate from the intestine, a variable output pressure source, at least one sensor positioned to detect environmental conditions in or near the discharge lumen, and a controller configured to determine an obstruction occurring in the discharge lumen based on a notification from the at least one sensor and, based on the determination, change the pressure from the output pressure source to purify the occurring obstruction. and a controller configured to determine an obstruction occurring in the discharge lumen based on a notification from the at least one sensor and, based on the determination, change the pressure from the output pressure source to purify the occurring obstruction. and a controller configured to determine an obstruction occurring in the discharge lumen based on a notification from the at least one sensor and, based on the determination, change the pressure from the output pressure source to purify the occurring obstruction. and a controller configured to determine an obstruction occurring in the discharge lumen based on a notification from the at least one sensor and, based on the determination, change the pressure from the output pressure source to purify the occurring obstruction. and a controller configured to determine an obstruction occurring in the discharge lumen based on a notification from the at least one sensor and, based on the determination, change the pressure from the output pressure source to purify the occurring obstruction. and a controller configured to determine an obstruction occurring in the discharge lumen based on a notification from the at least one sensor and, based on the determination, change the pressure from the output pressure source to purify the occurring obstruction.

[0007] According to some embodiments of the present invention, the output pressure source is configured to alternately apply pressure gradients in the proximal and distal directions to the discharge lumen. and a controller configured to determine an obstruction occurring in the discharge lumen based on a notification from the at least one sensor and, based on the determination, change the pressure from the output pressure source to purify the occurring obstruction.

[0008] According to some embodiments of the present invention, the length of the discharge lumen is at least equal to the length of the human colon. and a controller configured to determine an obstruction occurring in the discharge lumen based on a notification from the at least one sensor and, based on the determination, change the pressure from the output pressure source to purify the occurring obstruction.

[0009] According to some embodiments of the present invention, an occurring obstruction is determined when the discharge rate is equal to or greater than the injection rate of the perfusate into the intestine. and a controller configured to determine an obstruction occurring in the discharge lumen based on a notification from the at least one sensor and, based on the determination, change the pressure from the output pressure source to purify the occurring obstruction.

[0010] According to some embodiments of the present invention, an occurring obstruction is less than 50% of the cross-section of the discharge lumen. Form an occlusion.

[0011] According to some aspects of the present invention, an in-progress obstruction forms an occlusion that is less than 10% of the cross-section of the discharge lumen. Form an occlusion.

[0012] According to some aspects of the present invention, an in-progress obstruction has a discharge rate that has begun to decrease due to the progression of the occlusion state of the discharge lumen. Have a discharge rate that has begun to decrease due to the progression of the occlusion state of the discharge lumen.

[0013] According to some aspects of the present invention, an in-progress obstruction includes an obstruction detected within 100 milliseconds after the discharge lumen has reached more than 50% occlusion. Have a discharge rate that has begun to decrease due to the progression of the occlusion state of the discharge lumen.

[0014] According to some aspects of the present invention, an in-progress obstruction includes an obstruction detected within 50 milliseconds after the discharge lumen has reached more than 80% occlusion. Have a discharge rate that has begun to decrease due to the progression of the occlusion state of the discharge lumen.

[0015] The pressure change includes at least two cycles that increase the distal pressure and then decrease it. Including.

[0016] According to some aspects of the present invention, the controller is configured to re-determine an obstruction while changing the pressure. Have a discharge rate that has begun to decrease due to the progression of the occlusion state of the discharge lumen.

[0017] According to some aspects of the present invention, the controller is configured to adjust the pressure change based on the result of a re-determination that there is no change in the obstruction. Have a discharge rate that has begun to decrease due to the progression of the occlusion state of the discharge lumen.

[0018] According to some aspects of the present invention, the adjustment includes stopping the pressure change.

[0019] According to some aspects of the present invention, the adjustment includes increasing the pressure change.

[0020] According to some aspects of the present invention, the determination is a determination of the position of an in-progress obstruction within the system. including, the determination of the position is based on the change in pressure.

[0021] According to one aspect of some embodiments of the present invention, in the system according to claim 1, the following group, namely, (a) an outer surface of a distal portion of the discharge lumen and a sensor positioned outside the lumen, (b) a sensor inside the discharge lumen and positioned within 5 millimeters from the distal end of the discharge lumen, (c) a sensor inside the discharge lumen and positioned within 5 - 30 millimeters from the distal end of the discharge lumen, (d) a sensor inside the discharge lumen and positioned within 3 - 160 centimeters from the distal end of the discharge lumen, (e) a sensor inside the discharge lumen and positioned within 160 - 250 centimeters from the distal end of the discharge lumen, (e) a sensor inside the discharge lumen and positioned more than 250 centimeters away from the distal end of the discharge lumen, and (g) a sensor positioned inside a fluid supply tube that supplies a fluid flow to the distal portion of the discharge lumen, a system is provided that includes two or more of at least one sensor selected from the group consisting of.

[0022] According to some embodiments of the present invention, the output pressure source has a first pump configured to send a substance distally through the discharge lumen.

[0023] According to some embodiments of the present invention, the first pump is further configured to send a substance proximally through the discharge lumen.

[0024] According to some embodiments of the present invention, the output pressure source has a second pump configured to send a substance proximally through the discharge lumen.

[0025] According to some aspects of the present invention, the output pressure source has a valve and a vacuum source inlet, The valve is controllable, whereby the discharge lumen and the vacuum source inlet are connected and disconnected .

[0026] According to some aspects of the present invention, the output pressure source has a valve and a pressurized fluid inlet, The valve is controllable, whereby the discharge lumen and the pressurized fluid inlet are connected and disconnected .

[0027] According to some aspects of the present invention, at least one sensor includes an optical sensor.

[0028] According to some aspects of the present invention, the optical sensor senses at least any one of the group consisting of turbidity, particle size, particle number, or particle spectrum.

[0029] According to some aspects of the present invention, at least one sensor includes a sensor that senses bulk material properties .

[0030] According to some aspects of the present invention, the bulk material properties are at least any one of the group consisting of pH, conductivity, solute concentration, or osmotic pressure.

[0031] According to some aspects of the present invention, at least one sensor includes a flow sensor.

[0032] According to some aspects of the present invention, at least one sensor includes a fluid pressure sensor.

[0033] According to some aspects of the present invention, the determination of an interfering object during generation is based on the following group, namely, ( a) pressure from one or more sensors, (b) pressure difference between two or more sensors, (c) flow, ( d) Optical characteristics, and (e) changes sensed in bulk material characteristics, among the group consisting of include at least any one of them.

[0034] According to some aspects of the present invention, the system has a plurality of discharge lumens.

[0035] According to some aspects of the present invention, the pressure applied to each of the plurality of discharge lumens by an output pressure source is individually controllable.

[0036] According to some aspects of the present invention, the discharge pressure in the first discharge lumen among the plurality of discharge lumens is directed in the distal direction, and at the same time, the discharge pressure in the second discharge lumen among the plurality of discharge lumens is directed in the proximal direction.

[0037] According to some aspects of the present invention, the plurality of discharge lumens have a junction connection portion sized as a passage for the discharged substance within 100 centimeters from the distal end of the lumen.

[0038] According to some aspects of the present invention, at least one sensor is positioned to detect the pressure in the discharge lumen, and the determination of an ongoing obstruction includes the determination of a pressure change in the discharge lumen. includes the determination of a pressure change in the discharge lumen.

[0039] According to some aspects of the present invention, the determination of a pressure change includes the determination of the start of the pressure change.

[0040] According to some aspects of the present invention, the determination of a pressure change includes the determination of a pressure change of 10 millimeters of mercury or more within 100 milliseconds.

[0041] According to some aspects of the present invention, the determination of a pressure change includes the determination of a pressure change of 20 millimeters of mercury or more within 150 milliseconds. ​​​

[0042] According to some aspects of the present invention, the determination of the pressure change includes the determination of a pressure change of 30 mmHg or more within 200 milliseconds.

[0043] According to some aspects of the present invention, the determination of the pressure change includes the determination of a differential pressure change of 10 mmHg or more between two of at least one sensor within 100 milliseconds.

[0044] According to one aspect of some aspects of the present invention, there is provided a method for purifying an obstruction in the discharge lumen of an intestinal lavage system, the method comprising the steps of: inserting the discharge lumen into the colon by 50 cm or more; discharging excrement proximally from the colon through the discharge lumen; automatically detecting an obstruction occurring in the discharge lumen; and starting a change in the pressure of the discharge lumen based on the automatic detection of the obstruction.

[0045] According to some aspects of the present invention, the insertion is within 20 centimeters from the distal end of the colon.

[0046] According to some aspects of the present invention, the method includes the steps of automatically detecting that the occurring obstruction has decreased and stopping the automatic pressure change.

[0047] According to some aspects of the present invention, the change in pressure includes alternating the pressure in the discharge lumen between the distal pressure and the proximal pressure.

[0048] According to some aspects of the present invention, the change in pressure is made at a frequency of more than 1 Hz.

[0049] ​​According to some aspects of the present invention, the pressure change is at a frequency above 1 Hertz, and the pressure is reversed between the distal direction and the proximal direction.

[0050] According to some aspects of the present invention, the pressure change is made at a frequency above 5 Hertz.

[0051] According to some aspects of the present invention, the pressure change is at a frequency above 5 Hertz, and the pressure is reversed from the distal direction to the proximal direction.

[0052] According to some aspects of the present invention, the automatic detection is performed more than 5 times per minute.

[0053] According to some aspects of the present invention, the discharge lumen has a plurality of discharge sub-lumens arranged side by side, and the pressure change is controlled to apply the distal direction pressure to one discharge sub-lumen and the proximal direction pressure to another discharge sub-lumen.

[0054] According to some aspects of the present invention, the plurality of discharge sub-lumens are joined at a connection portion that allows liquid passage within 20 millimeters from the distal end of the discharge sub-lumen.

[0055] According to some aspects of the present invention, the initiated pressure change is adjusted based on the determined degree of the interfering substance during occurrence.

[0056] According to some aspects of the present invention, the initiated pressure change is adjusted based on the determined position of the interfering substance during occurrence.

[0057] According to some aspects of the present invention, the detection of the interfering substance during occurrence includes sensing a decrease in the flow of the discharge lumen.

[0058] ​​​​​​​​According to some aspects of the present invention, the detection of an in-progress obstruction involves sensing a pressure change in the drainage lumen. Including.

[0059] According to some aspects of the present invention, the detected in-progress obstruction is associated with the determined location of the obstruction, and the pressure change is adjusted based on the location of the obstruction. And the change in pressure is adjusted based on the location of the obstruction.

[0060] According to some aspects of the present invention, the method includes changing the pressure of the perfusion fluid supplied to the colon at the distal end of the drainage lumen. Including the step of changing the pressure of the perfusion fluid supplied to the colon at the distal end of the drainage lumen.

[0061] According to some aspects of the present invention, the supplied perfusion fluid washes the distal end of the drainage lumen. To wash.

[0062] According to one aspect of some aspects of the present invention, a system for washing the intestine, comprising a plurality of drainage lumens for discharging perfusion fluid from the intestine, and a pressure source configured to alternately apply a pressure gradient in the proximal and distal directions to each of the plurality of drainage lumens separately, and at least one sensor positioned to detect environmental conditions in or near the plurality of drainage lumens, wherein one or more of the at least one sensor is configured to notify the pressure level in the colon. At least one sensor, and a controller configured to determine the presence or absence of an obstruction in the drainage lumen based on a notification from the at least one sensor, determine whether the pressure level in the colon satisfies a pressure safety condition, and only when the pressure safety condition is satisfied, based on the presence or absence of the obstruction, A system is provided that has a controller configured to change the pressure from the pressure source to purify the obstruction. A plurality of drainage lumens for discharging perfusion fluid from the intestine, and a pressure source configured to alternately apply a pressure gradient in the proximal and distal directions to each of the plurality of drainage lumens separately, and at least one sensor positioned to detect environmental conditions in or near the plurality of drainage lumens, wherein one or more of the at least one sensor is configured to notify the pressure level in the colon. At least one sensor, and a controller configured to determine the presence or absence of an obstruction in the drainage lumen based on a notification from the at least one sensor, determine whether the pressure level in the colon satisfies a pressure safety condition, and only when the pressure safety condition is satisfied, based on the presence or absence of the obstruction, A system is provided that has a controller configured to change the pressure from the pressure source to purify the obstruction. A pressure source configured to alternately apply a pressure gradient in the proximal and distal directions to each of the plurality of drainage lumens separately, and at least one sensor positioned to detect environmental conditions in or near the plurality of drainage lumens, wherein one or more of the at least one sensor is configured to notify the pressure level in the colon. At least one sensor, and a controller configured to determine the presence or absence of an obstruction in the drainage lumen based on a notification from the at least one sensor, determine whether the pressure level in the colon satisfies a pressure safety condition, and only when the pressure safety condition is satisfied, based on the presence or absence of the obstruction, A system is provided that has a controller configured to change the pressure from the pressure source to purify the obstruction. At least one sensor positioned to detect environmental conditions in or near the plurality of drainage lumens, wherein one or more of the at least one sensor is configured to notify the pressure level in the colon. At least one sensor, and a controller configured to determine the presence or absence of an obstruction in the drainage lumen based on a notification from the at least one sensor, determine whether the pressure level in the colon satisfies a pressure safety condition, and only when the pressure safety condition is satisfied, based on the presence or absence of the obstruction, A system is provided that has a controller configured to change the pressure from the pressure source to purify the obstruction. Wherein one or more of the at least one sensor is configured to notify the pressure level in the colon. At least one sensor, and a controller configured to determine the presence or absence of an obstruction in the drainage lumen based on a notification from the at least one sensor, determine whether the pressure level in the colon satisfies a pressure safety condition, and only when the pressure safety condition is satisfied, based on the presence or absence of the obstruction, A system is provided that has a controller configured to change the pressure from the pressure source to purify the obstruction. At least one sensor configured to notify the pressure level in the colon, and a controller configured to determine the presence or absence of an obstruction in the drainage lumen based on a notification from the at least one sensor, determine whether the pressure level in the colon satisfies a pressure safety condition, and only when the pressure safety condition is satisfied, based on the presence or absence of the obstruction, A system is provided that has a controller configured to change the pressure from the pressure source to purify the obstruction. A controller configured to determine the presence or absence of an obstruction in the drainage lumen based on a notification from the at least one sensor, determine whether the pressure level in the colon satisfies a pressure safety condition, and only when the pressure safety condition is satisfied, based on the presence or absence of the obstruction, A system is provided that has a controller configured to change the pressure from the pressure source to purify the obstruction. Determine whether the pressure level in the colon satisfies a pressure safety condition, and only when the pressure safety condition is satisfied, based on the presence or absence of the obstruction, a controller configured to change the pressure from the pressure source to purify the obstruction. Based on the presence or absence of the obstruction, a controller configured to change the pressure from the pressure source to purify the obstruction. A controller configured to change the pressure from the pressure source to purify the obstruction, and a system is provided.

[0063] According to some aspects of the present invention, the pressure safety condition is satisfied if the pressure in the colon is less than 150 millimeters of mercury.

[0064] According to some aspects of the present invention, the pressure safety condition is satisfied if the pressure in the colon is less than 200 millimeters of mercury.

[0065] According to one aspect of some aspects of the present invention, a system for flushing the intestine, comprising a discharge lumen for discharging perfusate from the intestine, a pressure source configured to alternately apply proximal and distal pressure gradients to the discharge lumen, at least one sensor positioned to detect environmental conditions in or near the discharge lumen, and a controller configured to determine a restriction of flow in the discharge lumen based on a notification from the at least one sensor and, based on the determination, change the pressure from the pressure source to reduce the restriction of flow.

[0066] According to some aspects of the present invention, the restriction of flow includes a partial lining by substances accumulated on the wall of the discharge lumen.

[0067] According to some aspects of the present invention, the restriction of flow includes a change in the shape of the discharge lumen.

[0068] According to some aspects of the present invention, the restriction of flow includes turbulent flow in the discharge lumen.

[0069] Unless otherwise specified, all technical and / or scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the technical field to which the present invention belongs. Methods and materials similar or equivalent to those described herein can be used in the practice of aspects of the present invention. ​​​​​​​​​​Although it can also be used in practice or tests, exemplary methods and / or materials will be described below. In case of any conflict, this specification shall prevail, including the definitions. Also, the materials, methods and examples are illustrative only and are not necessarily intended to be limiting. As will be understood by those skilled in the art, aspects of the present invention can be implemented as a system, method or computer

[0070] ·program product. Accordingly, aspects of the present invention can take the form of an entirely hardware aspect, an entirely software aspect (e.g., firmware, resident software and microcode, etc.), or a combination of software aspects and hardware aspects, all of which can generally be referred to herein as a "circuit", "module" or "system". Further, aspects of the present invention can take the form of a computer ·program product implemented with one or more computer-readable media having computer-readable program code incorporated therein. The execution of the methods and / or systems according to the aspects of the present invention can include the execution or completion of selected tasks manually, automatically, or a combination of these. Furthermore, several selected steps can be performed by actual devices and apparatuses according to the aspects of the methods and / or systems of the present invention, by hardware, software, firmware, or a combination of these using an operating system. For example, the hardware for performing selected tasks according to aspects of the present invention can be implemented as a chip or circuit. As software, selected according to aspects of the present invention

[0071] The assigned tasks are the multiple tasks that the computer will execute using the appropriate operating system. In an exemplary embodiment of the present invention, the present invention may be implemented as a number of software instructions. One or more tasks according to exemplary embodiments of the methods and / or systems described herein may include: A computer processor, e.g., a computing platform that executes multiple instructions. Optionally, the data processor comprises a virtual memory for storing instructions and / or data. Volatile memory and / or non-volatile storage for storing instructions and / or data. devices (e.g., magnetic hard disks and / or removable storage media) Optionally, a network connection is also provided. Also, optionally, a keyboard A user input device such as a keyboard or mouse is also provided.

[0072] Any combination of one or more computer readable medium(s) may be utilized. The computer-readable medium may be a computer-readable signal medium or a computer-readable storage medium. The computer readable storage medium may include, but is not limited to, Systems, apparatus, devices using electronics, magnetism, optics, electromagnetics, infrared or semiconductors; Any suitable combination of these may be used. Specific examples (non-exhaustive list) include, for example, an electrical connection having one or more wires. , portable computer diskettes, hard disks, random access media RAM, read-only memory (ROM), erasable programmable read-only Memory (EPROM or flash memory), fiber optics, portable and compact A read-only memory (CDROM), an optical memory element, a magnetic memory element, or any suitable combination thereof may be mentioned. In the context of this specification, a computer-readable memory medium can be any tangible medium capable of accommodating or storing a program used by or in relation to an instruction execution system, apparatus, or device. .

[0073] A computer-readable signal medium may include a propagated data signal with, for example, computer-readable program code embedded within a baseband or as part of a carrier wave. Such propagated signals can take various forms, including, but not limited to, electromagnetic, optical, or any suitable combination thereof. A computer-readable signal medium is not a computer-readable storage medium and can be any computer-readable medium capable of communicating, propagating, or transmitting a program used by or in relation to an instruction execution system, apparatus, or device.

[0074] The program code incorporated on a computer-readable medium can be transmitted using any suitable medium, including, but not limited to, wireless, wired, fiber optic cable, RF, or any suitable combination thereof.

[0075] The computer program code for performing operations according to aspects of the present invention can be in object-oriented programming languages such as Java (trademark), Smalltalk, and C++, and conventional programming languages such as the "C" programming language or similar programming languages. Any combination of one or more programming languages, including future procedural programming languages, can be described in combination. The program code can be executed as a stand-alone software package entirely on the user's computer, or partially on the user's computer, or partially on the user's computer and partially on a remote computer, or entirely on a remote computer or server. In the latter case, the remote computer can be connected to the user's computer through any type of network, such as a local area network (LAN) or a wide area network (WAN), or can be connected to an external computer (e.g., through the Internet using an Internet service provider). It can be described in combination. The program code can be executed as a stand-alone software package entirely on the user's computer, or partially on the user's computer, or partially on the user's computer and partially on a remote computer, or entirely on a remote computer or server. In the latter case, the remote computer can be connected to the user's computer through any type of network, such as a local area network (LAN) or a wide area network (WAN), or can be connected to an external computer (e.g., through the Internet using an Internet service provider). package, either entirely on the user's computer or partially on the user's computer, and can be executed partially on the user's computer and partially on a remote computer, or entirely on a remote computer or server. In the latter case, the remote computer can be connected to the user's computer through any type of network, such as a local area network (LAN) or a wide area network (WAN), or can be connected to an external computer (e.g., through the Internet using an Internet service provider). puter, and partially on a remote computer, or entirely on a remote computer or server. In the latter case, the remote computer can be connected to the user's computer through any type of network, such as a local area network (LAN) or a wide area network (WAN), or can be connected to an external computer (e.g., through the Internet using an Internet service provider). or entirely on a remote computer or server. In the latter case, the remote computer can be connected to the user's computer through any type of network, such as a local area network (LAN) or a wide area network (WAN), or can be connected to an external computer (e.g., through the Internet using an Internet service provider). In the latter case, the remote computer can be connected to the user's computer through any type of network, such as a local area network (LAN) or a wide area network (WAN), or can be connected to an external computer (e.g., through the Internet using an Internet service provider). It can be connected to the user's computer through any type of network, such as a local area network (LAN) or a wide area network (WAN), or can be connected to an external computer (e.g., through the Internet using an Internet service provider). the user's computer, or can be connected to an external computer (e.g., through the Internet using an Internet service provider). the user's computer, or can be connected to an external computer (e.g., through the Internet using an Internet service provider).

[0076] Hereinafter, aspects of the present invention will be described with reference to the flowchart diagrams and / or block diagrams of methods, apparatuses (systems), and computer program products according to embodiments of the present invention. It will be understood that each block of the flowchart diagrams and / or block diagrams, and combinations of blocks in the flowchart diagrams and / or block diagrams, can be implemented by computer program instructions. These computer program instructions can be provided to a processor of a general-purpose computer, a special-purpose computer, or other programmable data processing apparatus to manufacture a machine, such that the instructions executed by the processor of the computer or other programmable data processing apparatus create means for implementing the functions / operations specified in one or more blocks of the flowchart and / or block diagrams. Hereinafter, aspects of the present invention will be described with reference to the flowchart diagrams and / or block diagrams of methods, apparatuses (systems), and computer program products according to embodiments of the present invention. It will be understood that each block of the flowchart diagrams and / or block diagrams, and combinations of blocks in the flowchart diagrams and / or block diagrams, can be implemented by computer program instructions. These computer program instructions can be provided to a processor of a general-purpose computer, a special-purpose computer, or other programmable data processing apparatus to manufacture a machine, such that the instructions executed by the processor of the computer or other programmable data processing apparatus create means for implementing the functions / operations specified in one or more blocks of the flowchart and / or block diagrams. Hereinafter, aspects of the present invention will be described with reference to the flowchart diagrams and / or block diagrams of methods, apparatuses (systems), and computer program products according to embodiments of the present invention. It will be understood that each block of the flowchart diagrams and / or block diagrams, and combinations of blocks in the flowchart diagrams and / or block diagrams, can be implemented by computer program instructions. These computer program instructions can be provided to a processor of a general-purpose computer, a special-purpose computer, or other programmable data processing apparatus to manufacture a machine, such that the instructions executed by the processor of the computer or other programmable data processing apparatus create means for implementing the functions / operations specified in one or more blocks of the flowchart and / or block diagrams. Hereinafter, aspects of the present invention will be described with reference to the flowchart diagrams and / or block diagrams of methods, apparatuses (systems), and computer program products according to embodiments of the present invention. It will be understood that each block of the flowchart diagrams and / or block diagrams, and combinations of blocks in the flowchart diagrams and / or block diagrams, can be implemented by computer program instructions. These computer program instructions can be provided to a processor of a general-purpose computer, a special-purpose computer, or other programmable data processing apparatus to manufacture a machine, such that the instructions executed by the processor of the computer or other programmable data processing apparatus create means for implementing the functions / operations specified in one or more blocks of the flowchart and / or block diagrams. Hereinafter, aspects of the present invention will be described with reference to the flowchart diagrams and / or block diagrams of methods, apparatuses (systems), and computer program products according to embodiments of the present invention. It will be understood that each block of the flowchart diagrams and / or block diagrams, and combinations of blocks in the flowchart diagrams and / or block diagrams, can be implemented by computer program instructions. These computer program instructions can be provided to a processor of a general-purpose computer, a special-purpose computer, or other programmable data processing apparatus to manufacture a machine, such that the instructions executed by the processor of the computer or other programmable data processing apparatus create means for implementing the functions / operations specified in one or more blocks of the flowchart and / or block diagrams. Hereinafter, aspects of the present invention will be described with reference to the flowchart diagrams and / or block diagrams of methods, apparatuses (systems), and computer program products according to embodiments of the present invention. It will be understood that each block of the flowchart diagrams and / or block diagrams, and combinations of blocks in the flowchart diagrams and / or block diagrams, can be implemented by computer program instructions. These computer program instructions can be provided to a processor of a general-purpose computer, a special-purpose computer, or other programmable data processing apparatus to manufacture a machine, such that the instructions executed by the processor of the computer or other programmable data processing apparatus create means for implementing the functions / operations specified in one or more blocks of the flowchart and / or block diagrams. Hereinafter, aspects of the present invention will be described with reference to the flowchart diagrams and / or block diagrams of methods, apparatuses (systems), and computer program products according to embodiments of the present invention. It will be understood that each block of the flowchart diagrams and / or block diagrams, and combinations of blocks in the flowchart diagrams and / or block diagrams, can be implemented by computer program instructions. These computer program instructions can be provided to a processor of a general-purpose computer, a special-purpose computer, or other programmable data processing apparatus to manufacture a machine, such that the instructions executed by the processor of the computer or other programmable data processing apparatus create means for implementing the functions / operations specified in one or more blocks of the flowchart and / or block diagrams. Hereinafter, aspects of the present invention will be described with reference to the flowchart diagrams and / or block diagrams of methods, apparatuses (systems), and computer program products according to embodiments of the present invention. It will be understood that each block of the flowchart diagrams and / or block diagrams, and combinations of blocks in the flowchart diagrams and / or block diagrams, can be implemented by computer program instructions. These computer program instructions can be provided to a processor of a general-purpose computer, a special-purpose computer, or other programmable data processing apparatus to manufacture a machine, such that the instructions executed by the processor of the computer or other programmable data processing apparatus create means for implementing the functions / operations specified in one or more blocks of the flowchart and / or block diagrams. Hereinafter, aspects of the present invention will be described with reference to the flowchart diagrams and / or block diagrams of methods, apparatuses (systems), and computer program products according to embodiments of the present invention. It will be understood that each block of the flowchart diagrams and / or block diagrams, and combinations of blocks in the flowchart diagrams and / or block diagrams, can be implemented by computer program instructions. These computer program instructions can be provided to a processor of a general-purpose computer, a special-purpose computer, or other programmable data processing apparatus to manufacture a machine, such that the instructions executed by the processor of the computer or other programmable data processing apparatus create means for implementing the functions / operations specified in one or more blocks of the flowchart and / or block diagrams. It can be done.

[0077] These computer program instructions can be instructed to cause a computer, other programmable data processing apparatus, or other devices to function in a specific manner, and can be stored in a computer-readable medium. The instructions stored in the computer-readable medium include instructions for implementing the functions / operations specified in one or more blocks of a flowchart and / or block diagram. It is also possible to manufacture a product that includes such

[0078] instructions. The computer program instructions can be loaded into a computer, other programmable data processing apparatus, or other devices, causing a series of operational steps to be performed on the computer, other programmable data processing apparatus, or other devices, thereby generating a computer-implemented process. The instructions executed on the computer or other programmable device provide a process for implementing the functions / operations specified in one or more blocks of a flowchart and / or block diagram.

[0079] In this specification, some embodiments of the present invention will be described with reference to the accompanying drawings. However, these are merely examples. Here, the drawings are specifically and in detail referred to. It should be emphasized that the details shown are merely for illustration purposes and are for the purpose of exemplarily explaining the embodiments of the present invention. With respect to this

[0080]

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DETAILED DESCRIPTION OF THE INVENTION

[0081] In some aspects, the present invention is for cleaning the colon and other body lumens Regarding the system, more specifically, but not limited to the following, an automated self- It relates to a cleaning system and a cleaning method having cleaning characteristics. (Summary)

[0082] Some of the main aspects of the embodiments of the present invention relate to devices and techniques for purifying the discharge channel of a cleaning system from fecal matter or other substances related to the obstruction of the discharge channel. It concerns.

[0083] In some embodiments of the present invention, one or more perfusion channels carry the perfusion substance to the distal end of the colon cleaning system. Also, one or more discharge channels return substances along with the excrement of the colon. In some embodiments, the transport is reversible and / or otherwise variably controllable. In some cases, by controlling the discharge flow, while reducing the need for interruption of the process due to equipment failure, obstructions during use are removed or reduced.

[0084] One aspect of some embodiments of the present invention relates to sensors for conditions in the colon cleaning system and / or its operating environment. It concerns.

[0085] In some embodiments of the present invention, one or more sensors detect the pressure inside the intestine or the cleaning system. It detects.

[0086] Additionally and / or alternatively, the sensor detects other characteristics of substances inside or outside the system, for example, flow, flow rate, temperature, conductivity, optical density, spectral characteristics, pH, and / or osmotic pressure. In some embodiments, the sensor monitors the components of the system. Examples include a pump volumeter, a filling level sensor, and / or a valve or suction position sensor. It is mentioned.

[0087] In some embodiments, the distal sensor is connected to the workstation by wired or wireless radio waves. Additionally and / or alternatively, the sensor of the workstation senses the pressure of one or more sensing ducts with distal outlets.

[0088] It is considered effective to provide a sensor that can indicate potentially and / or newly formed flow obstructions at an early stage when the obstructions are formed. Optionally, the obstruction includes an obstructive substance carried by the discharged fluid. Optionally, the obstructive substance includes lumps. Optionally, the obstructive substance includes deposits on the discharge lumen wall. Possibly, early detection can initiate an operation to purify the forming obstruction before it blocks the discharge function. It is considered that the obstructive substance is easier to purify the earlier its presence or absence is sensed. Optionally, the obstruction constitutes a flow restriction due to a change in the shape of the discharge lumen. The change can be due to, for example, kinking within the discharge lumen or a reduced pressure. Possibly, the pressure change in the discharge lumen reduces the flow restriction. Optionally, the flow restriction includes resistance due to turbulent flow. Possibly, the pressure change applied to the discharge lumen reduces turbulent flow and the associated resistance.

[0089] One aspect of some embodiments of the present invention relates to the use of sensed and / or determined system states to determine control signals for operating the components of a colon cleansing system. Changes in sensing during controlled operation optionally enable control by commands to the system and / or closed-loop control.

[0090] In some embodiments of the present invention, sensor data is processed to determine a state. For example Illustrative states include channel obstructions and intestinal pressure. In some embodiments Based on the determination of obstructions in the system's discharge channel, a signal is induced to operate the colon cleansing system for cleaning the obstructions. For example, when an obstruction at the tip is determined, a signal to stop suction is induced. Optionally, the control signal is adjusted based on the details of the state determination. Details to be determined include, for example, whether the obstruction is full, partial or in progress, the location of the obstruction, and / or the type of obstruction (e.g., excrement particles or aspirated cells).

[0091] Operation control for the purification of obstructions and potential obstructions is considered effective in reducing obstructions in the discharge flow. When substances adhere to the colon, it may cause a delay in the progress of the process and / or an obstruction to visual inspection at the end of purification. Adhesion of substances that cause an increase in pressure is also a potential danger to the patient.

[0092] In some embodiments of the present invention, sensing and control interact through feedback. In one example of feedback, the direction of flow is repeated in the channel until the determined obstruction situation is alleviated. In another example, a change in the probe pressure under control is commanded. The speed at which these are sensed and propagated through the channel may, in some cases, indicate the relative volumes of incompressible fluid and compressible gas, and / or the capacitance of the flow. In some cases, this may indicate foaming of the discharge fluid. Based on this or another actually sensed state, the parameters of timing, pressure and / or flow control are optionally changed. In another example, the control signal ​​​​​​​​​​​​ is maintained by such that the balance of relative effects sensed by two or more subsystems is maintained. Optionally alternatively, this is useful for maintaining a balance between the infusion volume and the drainage volume.

[0093] In some embodiments, a fault condition (e.g., intestinal overpressure, an immovable obstruction , or an unexpected sensor value) causes a control response. As a fault response, for example, shutdown, suspension, a decrease and / or an increase in the utilization rate of system components are included .

[0094] In some embodiments, feedback from a sensor is used to control the flow of a fluid feeding system that feeds a fluid mixed with fecal matter to be discharged. In some embodiments the fluid to be fed includes a gas, e.g., carbon dioxide and / or air. In some embodiments, the fluid to be fed includes a liquid, e.g., water or saline. In some embodiments of the present invention, the feed includes a mixture of gas and water, e.g., water and gas ejected together from a fluid supply pipe . In some embodiments, the sensing of the pressure in the intestine is used to detect an actual, intrinsic, occurring, and / or potentially occurring intestinal overpressure (all of these are referred to as overpressure conditions herein) . As an overpressure condition, for example, a pressure exceeding a safety limit point, and / or a changing pressure that will reach the safety limit point soon from the rate of change are included. In some embodiments, the system responds to the overpressure condition by reducing the fluid supply rate, changing the ratio of gas to liquid in the fluid supply (e.g., reducing the gas volume), and / or stopping the fluid supply. In some embodiments, with respect to the fluid supply a change in the ratio of gas to liquid in the fluid supply (e.g., a decrease in the gas volume), and / or by stopping the fluid supply, the system responds to the overpressure condition. In some embodiments, with respect to the fluid supply ​​The ratio of the discharge rate is adjusted. Optionally, even if the discharge rate increases, the fluid supply rate remains constant. In some embodiments of the present invention, the fluid supply is temporarily stopped. In some embodiments of the present invention, (additionally or alternatively) other restrictions are imposed, for example, restrictions on the length of the irrigation sheath. In some embodiments of the present invention, a sensor is disposed outside the lumen of the cleaning system at the distal end of the cleaning system (which can be positioned, for example, at the end of the intestine), and is directly exposed to the pressure in the intestine. The sensed pressure is utilized as a criterion for detecting overpressure and feedback control. In some embodiments, when discharging and irrigating, the overpressure is adjusted by appropriate operations (increase and decrease of the material flow) according to the commands of the controller so that the balance of the input and output of the pressure of the cleaning device and / or the fluid source to the colon is maintained. In some embodiments, the control of irrigation includes stopping and reducing irrigation when performing a purifying operation for cleaning and / or preventing obstructions in the discharge lumen. In some embodiments of the present invention, the fluid supply is temporarily stopped. In some embodiments of the present invention, (additionally or alternatively) other restrictions are imposed, for example, restrictions on the length of the irrigation sheath. In some embodiments of the present invention, a sensor is disposed outside the lumen of the cleaning system at the distal end of the cleaning system (which can be positioned, for example, at the end of the intestine), and is directly exposed to the pressure in the intestine. The sensed pressure is utilized as a criterion for detecting overpressure and feedback control. In some embodiments, when discharging and irrigating, the overpressure is adjusted by appropriate operations (increase and decrease of the material flow) according to the commands of the controller so that the balance of the input and output of the pressure of the cleaning device and / or the fluid source to the colon is maintained. In some embodiments, the control of irrigation includes stopping and reducing irrigation when performing a purifying operation for cleaning and / or preventing obstructions in the discharge lumen. In some embodiments of the present invention, (additionally or alternatively) other restrictions are imposed, for example, restrictions on the length of the irrigation sheath. In some embodiments of the present invention, a sensor is disposed outside the lumen of the cleaning system at the distal end of the cleaning system (which can be positioned, for example, at the end of the intestine), and is directly exposed to the pressure in the intestine. The sensed pressure is utilized as a criterion for detecting overpressure and feedback control. In some embodiments, when discharging and irrigating, the overpressure is adjusted by appropriate operations (increase and decrease of the material flow) according to the commands of the controller so that the balance of the input and output of the pressure of the cleaning device and / or the fluid source to the colon is maintained. In some embodiments, the control of irrigation includes stopping and reducing irrigation when performing a purifying operation for cleaning and / or preventing obstructions in the discharge lumen. In some embodiments of the present invention, a sensor is disposed outside the lumen of the cleaning system at the distal end of the cleaning system (which can be positioned, for example, at the end of the intestine), and is directly exposed to the pressure in the intestine. The sensed pressure is utilized as a criterion for detecting overpressure and feedback control. In some embodiments, when discharging and irrigating, the overpressure is adjusted by appropriate operations (increase and decrease of the material flow) according to the commands of the controller so that the balance of the input and output of the pressure of the cleaning device and / or the fluid source to the colon is maintained. In some embodiments, the control of irrigation includes stopping and reducing irrigation when performing a purifying operation for cleaning and / or preventing obstructions in the discharge lumen. In some embodiments of the present invention, a sensor is disposed outside the lumen of the cleaning system at the distal end of the cleaning system (which can be positioned, for example, at the end of the intestine), and is directly exposed to the pressure in the intestine. The sensed pressure is utilized as a criterion for detecting overpressure and feedback control. In some embodiments, when discharging and irrigating, the overpressure is adjusted by appropriate operations (increase and decrease of the material flow) according to the commands of the controller so that the balance of the input and output of the pressure of the cleaning device and / or the fluid source to the colon is maintained. In some embodiments, the control of irrigation includes stopping and reducing irrigation when performing a purifying operation for cleaning and / or preventing obstructions in the discharge lumen. In some embodiments of the present invention, a sensor is disposed outside the lumen of the cleaning system at the distal end of the cleaning system (which can be positioned, for example, at the end of the intestine), and is directly exposed to the pressure in the intestine. The sensed pressure is utilized as a criterion for detecting overpressure and feedback control. In some embodiments, when discharging and irrigating, the overpressure is adjusted by appropriate operations (increase and decrease of the material flow) according to the commands of the controller so that the balance of the input and output of the pressure of the cleaning device and / or the fluid source to the colon is maintained. In some embodiments, the control of irrigation includes stopping and reducing irrigation when performing a purifying operation for cleaning and / or preventing obstructions in the discharge lumen. In some embodiments, when discharging and irrigating, the overpressure is adjusted by appropriate operations (increase and decrease of the material flow) according to the commands of the controller so that the balance of the input and output of the pressure of the cleaning device and / or the fluid source to the colon is maintained. In some embodiments, the control of irrigation includes stopping and reducing irrigation when performing a purifying operation for cleaning and / or preventing obstructions in the discharge lumen. In some embodiments, when discharging and irrigating, the overpressure is adjusted by appropriate operations (increase and decrease of the material flow) according to the commands of the controller so that the balance of the input and output of the pressure of the cleaning device and / or the fluid source to the colon is maintained. In some embodiments, the control of irrigation includes stopping and reducing irrigation when performing a purifying operation for cleaning and / or preventing obstructions in the discharge lumen. In some embodiments, when discharging and irrigating, the overpressure is adjusted by appropriate operations (increase and decrease of the material flow) according to the commands of the controller so that the balance of the input and output of the pressure of the cleaning device and / or the fluid source to the colon is maintained. In some embodiments, the control of irrigation includes stopping and reducing irrigation when performing a purifying operation for cleaning and / or preventing obstructions in the discharge lumen. In some embodiments, when discharging and irrigating, the overpressure is adjusted by appropriate operations (increase and decrease of the material flow) according to the commands of the controller so that the balance of the input and output of the pressure of the cleaning device and / or the fluid source to the colon is maintained. In some embodiments, the control of irrigation includes stopping and reducing irrigation when performing a purifying operation for cleaning and / or preventing obstructions in the discharge lumen. In some embodiments, the control of irrigation includes stopping and reducing irrigation when performing a purifying operation for cleaning and / or preventing obstructions in the discharge lumen.

[0095] In some embodiments, the operator's input affects the control signal, for example, the start, duration, and / or intensity of irrigation and / or suction. In some embodiments, the parameters related to the operation of the device include control by a timer, for example, within a pre-programmed cleaning cycle, or control as a restrictive safety mechanism for preventing intestinal overflow. In some embodiments, the operator's input affects the control signal, for example, the start, duration, and / or intensity of irrigation and / or suction. In some embodiments, the parameters related to the operation of the device include control by a timer, for example, within a pre-programmed cleaning cycle, or control as a restrictive safety mechanism for preventing intestinal overflow. In some embodiments, the operator's input affects the control signal, for example, the start, duration, and / or intensity of irrigation and / or suction. In some embodiments, the parameters related to the operation of the device include control by a timer, for example, within a pre-programmed cleaning cycle, or control as a restrictive safety mechanism for preventing intestinal overflow. In some embodiments, the parameters related to the operation of the device include control by a timer, for example, within a pre-programmed cleaning cycle, or control as a restrictive safety mechanism for preventing intestinal overflow.

[0096] One aspect of some embodiments of the present invention relates to the configuration of the lumen cross-sectional area where discharge and / or irrigation is performed. One aspect of some embodiments of the present invention relates to the configuration of the lumen cross-sectional area where discharge and / or irrigation is performed.

[0097] In some embodiments of the present invention, one large channel is replaced with a plurality of discharge channels. Replace. Optionally, by allowing a reduction in the maximum probe diameter, the same cross-section can be obtained as a whole. The diameter is a factor related to the flexibility of the probe, which can affect the success rate of the colonoscopy examination method. Possibly, by using multiple discharge channels, optional independent operation and / or improvement in the reliability of the operation can be achieved. is an element related to the flexibility of the probe, which can affect the success rate of the colonoscopy examination method. Possibly, by using multiple discharge channels, optional independent operation and / or improvement in the reliability of the operation can be achieved. Before describing at least one embodiment of the present invention, it should be understood that the present invention is not necessarily limited to the details of the components and / or the configuration and arrangement of the method shown in the following description and / or drawings in its application. The present invention can be implemented in other embodiments or can be implemented or executed in various ways. Before describing at least one embodiment of the present invention, it should be understood that the present invention is not necessarily limited to the details of the components and / or the configuration and arrangement of the method shown in the following description and / or drawings in its application. The present invention can be implemented in other embodiments or can be implemented or executed in various ways.

[0098] Before describing at least one embodiment of the present invention, it should be understood that the present invention is not necessarily limited to the details of the components and / or the configuration and arrangement of the method shown in the following description and / or drawings in its application. The present invention can be implemented in other embodiments or can be implemented or executed in various ways. For the sake of convenience of explanation, the cleaning system and cleaning method described in this specification may also be referred to as a "colon cleaning" system and method. Colon cleaning is considered to be a common part of the embodiments of the present invention. However, it should be understood that the methods and devices described in this specification can also be used for cleaning other parts of the intestine and / or other body lumens. Therefore, the term "colon cleaning" applied to such methods and devices includes cleaning not only the colon but also other parts of the intestine and / or other body lumens. For the sake of convenience of explanation, the cleaning system and cleaning method described in this specification may also be referred to as a "colon cleaning" system and method. Colon cleaning is considered to be a common part of the embodiments of the present invention. However, it should be understood that the methods and devices described in this specification can also be used for cleaning other parts of the intestine and / or other body lumens. Therefore, the term "colon cleaning" applied to such methods and devices includes cleaning not only the colon but also other parts of the intestine and / or other body lumens. For the sake of convenience of explanation, the cleaning system and cleaning method described in this specification may also be referred to as a "colon cleaning" system and method. Colon cleaning is considered to be a common part of the embodiments of the present invention. However, it should be understood that the methods and devices described in this specification can also be used for cleaning other parts of the intestine and / or other body lumens. Therefore, the term "colon cleaning" applied to such methods and devices includes cleaning not only the colon but also other parts of the intestine and / or other body lumens.

[0099] For the sake of convenience of explanation, the cleaning system and cleaning method described in this specification may also be referred to as a "colon cleaning" system and method. Colon cleaning is considered to be a common part of the embodiments of the present invention. However, it should be understood that the methods and devices described in this specification can also be used for cleaning other parts of the intestine and / or other body lumens. Therefore, the term "colon cleaning" applied to such methods and devices includes cleaning not only the colon but also other parts of the intestine and / or other body lumens. For the sake of convenience of explanation, the cleaning system and cleaning method described in this specification may also be referred to as a "colon cleaning" system and method. Colon cleaning is considered to be a common part of the embodiments of the present invention. However, it should be understood that the methods and devices described in this specification can also be used for cleaning other parts of the intestine and / or other body lumens. Therefore, the term "colon cleaning" applied to such methods and devices includes cleaning not only the colon but also other parts of the intestine and / or other body lumens. For the sake of convenience of explanation, the cleaning system and cleaning method described in this specification may also be referred to as a "colon cleaning" system and method. Colon cleaning is considered to be a common part of the embodiments of the present invention. However, it should be understood that the methods and devices described in this specification can also be used for cleaning other parts of the intestine and / or other body lumens. Therefore, the term "colon cleaning" applied to such methods and devices includes cleaning not only the colon but also other parts of the intestine and / or other body lumens. For the sake of convenience of explanation, the cleaning system and cleaning method described in this specification may also be referred to as a "colon cleaning" system and method. Colon cleaning is considered to be a common part of the embodiments of the present invention. However, it should be understood that the methods and devices described in this specification can also be used for cleaning other parts of the intestine and / or other body lumens. Therefore, the term "colon cleaning" applied to such methods and devices includes cleaning not only the colon but also other parts of the intestine and / or other body lumens. For the sake of convenience of explanation, the cleaning system and cleaning method described in this specification may also be referred to as a "colon cleaning" system and method. Colon cleaning is considered to be a common part of the embodiments of the present invention. However, it should be understood that the methods and devices described in this specification can also be used for cleaning other parts of the intestine and / or other body lumens. Therefore, the term "colon cleaning" applied to such methods and devices includes cleaning not only the colon but also other parts of the intestine and / or other body lumens. For the sake of convenience of explanation, the cleaning system and cleaning method described in this specification may also be referred to as a "colon cleaning" system and method. Colon cleaning is considered to be a common part of the embodiments of the present invention. However, it should be understood that the methods and devices described in this specification can also be used for cleaning other parts of the intestine and / or other body lumens. Therefore, the term "colon cleaning" applied to such methods and devices includes cleaning not only the colon but also other parts of the intestine and / or other body lumens. (Reference Embodiment of the Cleaning System Using a Colonoscope)

[0100] Here, refer to FIG. 1. FIG. 1 is a diagram schematically showing a colon cleaning system having a colonoscope workstation 19 and a cleaning workstation 31 according to some exemplary embodiments of the present invention. Here, refer to FIG. 1. FIG. 1 is a diagram schematically showing a colon cleaning system having a colonoscope workstation 19 and a cleaning workstation 31 according to some exemplary embodiments of the present invention. Here, refer to FIG. 1. FIG. 1 is a diagram schematically showing a colon cleaning system having a colonoscope workstation 19 and a cleaning workstation 31 according to some exemplary embodiments of the present invention.

[0101] In some exemplary embodiments of the present invention, the colonoscope workstation 19 and the washing workstation 31 are connected via a water or gas pipe 33. Optionally, one end of the pipe 33 is connected to the water or gas pipe 32 of the washing workstation 31, and the other end is connected to the water or gas inlet 18 of the colonoscope 19. Optionally, the supply line 11 of the colonoscope has an inner tube 16. The supply line 11 of the colonoscope is connected to the insertion tube 13 of the colonoscope via the colonoscope handle 12. In some embodiments, the handle 12 has a vacuum valve 20 and a working channel inlet 21. The state where the tip 14 of the colonoscope is passed through the colon 1 filled with fecal matter 2 is illustrated. In some exemplary embodiments, one end of the washing workstation pump 34 is connected to the colonoscope working channel 21 via a pipe 35, and the other end is connected to a fluid container 8. In some embodiments, the colonoscope vacuum inlet 17 is connected to the fluid container 8 via a fluid path 9A. Optionally, the suction wall pump 6 is connected to the container 8 through a regulator 7 and via a passage 9B. In some embodiments of the present invention, the operating pump 32 increases the perfusion of the colon by supplying gas and / or water to the colonoscope workstation 19 through the pipe 33 and the inlet 18. In some embodiments, the perfusion substance is supplied to the tip 14 of the colonoscope through the inner tube 16 and the working channel 15, increasing the colon 1 being washed containing fecal matter 2. In some embodiments of the present invention, the supplied gas includes, for example, air or carbon dioxide. In some exemplary embodiments, one end of the pipe 33 is connected to the water or gas pipe 32 of the washing workstation 31, and the other end is connected to the water or gas inlet 18 of the colonoscope 19. Optionally, the supply line 11 of the colonoscope has an inner tube 16. The supply line 11 of the colonoscope is connected to the insertion tube 13 of the colonoscope via the colonoscope handle 12. In some embodiments, the handle 12 has a vacuum valve 20 and a working channel inlet 21. The state where the tip 14 of the colonoscope is passed through the colon 1 filled with fecal matter 2 is illustrated. In some exemplary embodiments, one end of the washing workstation pump 34 is connected to the colonoscope working channel 21 via a pipe 35, and the other end is connected to a fluid container 8. In some embodiments, the colonoscope vacuum inlet 17 is connected to the fluid container 8 via a fluid path 9A. Optionally, the suction wall pump 6 is connected to the container 8 through a regulator 7 and via a passage 9B. In some embodiments of the present invention, the operating pump 32 increases the perfusion of the colon by supplying gas and / or water to the colonoscope workstation 19 through the pipe 33 and the inlet 18. In some embodiments, the perfusion substance is supplied to the tip 14 of the colonoscope through the inner tube 16 and the working channel 15, increasing the colon 1 being washed containing fecal matter 2. In some embodiments of the present invention, the supplied gas includes, for example, air or carbon dioxide. In some exemplary embodiments, one end of the pipe 33 is connected to the water or gas pipe 32 of the washing workstation 31, and the other end is connected to the water or gas inlet 18 of the colonoscope 19. Optionally, the supply line 11 of the colonoscope has an inner tube 16. The supply line 11 of the colonoscope is connected to the insertion tube 13 of the colonoscope via the colonoscope handle 12. In some embodiments, the handle 12 has a vacuum valve 20 and a working channel inlet 21. The state where the tip 14 of the colonoscope is passed through the colon 1 filled with fecal matter 2 is illustrated. In some exemplary embodiments, one end of the washing workstation pump 34 is connected to the colonoscope working channel 21 via a pipe 35, and the other end is connected to a fluid container 8. In some embodiments, the colonoscope vacuum inlet 17 is connected to the fluid container 8 via a fluid path 9A. Optionally, the suction wall pump 6 is connected to the container 8 through a regulator 7 and via a passage 9B.

[0102] In some exemplary embodiments, one end of the washing workstation pump 34 is connected to the colonoscope working channel 21 via a pipe 35, and the other end is connected to a fluid container 8. In some embodiments, the colonoscope vacuum inlet 17 is connected to the fluid container 8 via a fluid path 9A. Optionally, the suction wall pump 6 is connected to the container 8 through a regulator 7 and via a passage 9B. In some embodiments of the present invention, the operating pump 32 increases the perfusion of the colon by supplying gas and / or water to the colonoscope workstation 19 through the pipe 33 and the inlet 18. In some embodiments, the perfusion substance is supplied to the tip 14 of the colonoscope through the inner tube 16 and the working channel 15, increasing the colon 1 being washed containing fecal matter 2. In some embodiments of the present invention, the supplied gas includes, for example, air or carbon dioxide. In some exemplary embodiments, one end of the pipe 33 is connected to the water or gas pipe 32 of the washing workstation 31, and the other end is connected to the water or gas inlet 18 of the colonoscope 19. Optionally, the supply line 11 of the colonoscope has an inner tube 16. The supply line 11 of the colonoscope is connected to the insertion tube 13 of the colonoscope via the colonoscope handle 12. In some embodiments, the handle 12 has a vacuum valve 20 and a working channel inlet 21. The state where the tip 14 of the colonoscope is passed through the colon 1 filled with fecal matter 2 is illustrated. In some exemplary embodiments, one end of the washing workstation pump 34 is connected to the colonoscope working channel 21 via a pipe 35, and the other end is connected to a fluid container 8. In some embodiments, the colonoscope vacuum inlet 17 is connected to the fluid container 8 via a fluid path 9A. Optionally, the suction wall pump 6 is connected to the container 8 through a regulator 7 and via a passage 9B. In some embodiments of the present invention, the operating pump 32 increases the perfusion of the colon by supplying gas and / or water to the colonoscope workstation 19 through the pipe 33 and the inlet 18. In some embodiments, the perfusion substance is supplied to the tip 14 of the colonoscope through the inner tube 16 and the working channel 15, increasing the colon 1 being washed containing fecal matter 2. In some embodiments of the present invention, the supplied gas includes, for example, air or carbon dioxide.

[0103] In some embodiments of the present invention, the operating pump 32 increases the perfusion of the colon by supplying gas and / or water to the colonoscope workstation 19 through the pipe 33 and the inlet 18. In some embodiments, the perfusion substance is supplied to the tip 14 of the colonoscope through the inner tube 16 and the working channel 15, increasing the colon 1 being washed containing fecal matter 2. In some embodiments of the present invention, the supplied gas includes, for example, air or carbon dioxide. In some embodiments of the present invention, the operating pump 32 increases the perfusion of the colon by supplying gas and / or water to the colonoscope workstation 19 through the pipe 33 and the inlet 18. In some embodiments, the perfusion substance is supplied to the tip 14 of the colonoscope through the inner tube 16 and the working channel 15, increasing the colon 1 being washed containing fecal matter 2. In some embodiments of the present invention, the supplied gas includes, for example, air or carbon dioxide. In some embodiments of the present invention, the operating pump 32 increases the perfusion of the colon by supplying gas and / or water to the colonoscope workstation 19 through the pipe 33 and the inlet 18. In some embodiments, the perfusion substance is supplied to the tip 14 of the colonoscope through the inner tube 16 and the working channel 15, increasing the colon 1 being washed containing fecal matter 2. In some embodiments of the present invention, the supplied gas includes, for example, air or carbon dioxide. In some embodiments of the present invention, the operating pump 32 increases the perfusion of the colon by supplying gas and / or water to the colonoscope workstation 19 through the pipe 33 and the inlet 18. In some embodiments, the perfusion substance is supplied to the tip 14 of the colonoscope through the inner tube 16 and the working channel 15, increasing the colon 1 being washed containing fecal matter 2. In some embodiments of the present invention, the supplied gas includes, for example, air or carbon dioxide. In some embodiments of the present invention, the operating pump 32 increases the perfusion of the colon by supplying gas and / or water to the colonoscope workstation 19 through the pipe 33 and the inlet 18. In some embodiments, the perfusion substance is supplied to the tip 14 of the colonoscope through the inner tube 16 and the working channel 15, increasing the colon 1 being washed containing fecal matter 2. In some embodiments of the present invention, the supplied gas includes, for example, air or carbon dioxide. In some embodiments of the present invention, the operating pump 32 increases the perfusion of the colon by supplying gas and / or water to the colonoscope workstation 19 through the pipe 33 and the inlet 18. In some embodiments, the perfusion substance is supplied to the tip 14 of the colonoscope through the inner tube 16 and the working channel 15, increasing the colon 1 being washed containing fecal matter 2. In some embodiments of the present invention, the supplied gas includes, for example, air or carbon dioxide.

[0104] In some embodiments of the invention, fecal matter is discharged through the colonoscope working channel 15 and the inner tube 16 using the vacuum inlet 17. Optionally, by means of the regulator 7, the inlet 6 supplies a low pressure to the pipe paths 9B and 9A, thereby sucking the fecal matter into the fluid container 8.

[0105] In some embodiments, the cleaning working station 31 increases the discharge as needed. Optionally, the operating pump 34 and / or the opening inlet 21 create a pressure difference, thereby causing the substance to move into the fluid container 8 through the pipe 35.

[0106] According to an embodiment of the present invention, the colon cleaning system constitutes a colonoscope or is a component of a colonoscope. Alternatively and / or additionally, some embodiments described herein are separate from the colonoscope and can be implemented as a cleaning system that can optionally be used in combination with the colonoscope.

[0107] In some embodiments of the present invention, some components are provided by a colonoscope used in combination with the colon cleaning system. For example, in some embodiments of the cleaning system according to the present invention, the working channel of the colonoscope is used as an irrigation channel and / or a substance discharge channel (herein also referred to as a discharge lumen). In some embodiments, the components are provided separately from the colonoscope. For example, in some embodiments of the cleaning system according to the present invention, an external channel or other instrument of the colonoscope is used as an irrigation channel, a discharge channel, and / or other system components. (Exemplary Cleaning System Sensors and Power Devices) ​​​​​​​​​​​​​​

[0108] Referring now to FIG. 2A, FIG. 2A schematically shows a colon cleansing system 207 having a sensor according to some

[0109] exemplary embodiments of the present invention. In some embodiments of the present invention, the cleansing system 207 has one or more power devices that move fluid through channels (e.g., pumps 214, 214.3, and 214.4). Optionally, the power device is operated by a signal from a controller 213.

[0110] Optionally, the controller 213 determines a control signal based on inputs from one or more sensors 204. In some embodiments of the present invention, the cleansing system 207 has an insertable portion 200 that can be inserted into a patient's colon 1 and an outer workstation 210. In some (Exemplary power devices)

[0111] embodiments, the system 207 has an irrigation pipe 201 through which irrigation fluid, such as water and / or other liquids, can be supplied into the colon 1. The irrigation pipe 201 can be connected to a water source or other liquid source 211. The system 207 optionally has one or more excrement collection The fecal matter (relaxed and / or transported by the liquid from 01) is discharged from the colon 1 through the discharge channel 203 to the excrement collection devices 212A and 212W.

[0112] In some embodiments of the present invention, the discharge pumps 214.3 and 214.4 are outside the device and are. Optionally, the discharge pumps 214.3 and 214.4 are connected to a vacuum supplied by a remote pump such as obtained by a vacuum source connector available at many hospitals and clinics . In this case, the references in this specification to the control of the pumps 214.3 and 214.4 (e.g. starting and stopping the suction generation operation) should be understood as referring to the control of the valve connecting the discharge pipe of the cleaning system to such a remote vacuum source.

[0113] In some embodiments of the present invention, the system 207 has a pressure sensor 204 positioned above or near the distal end of the discharge channel 203 to measure the pressure within the colon 1 . In some embodiments, the sensor 204 notifies the controller 213 of the pressure indication. Optionally, the controller 213 controls the operation of one or more of the pumps 214, 214.3 and / or 214.4. Examples of operation control include starting, stopping, and / or changing the speed or power of the pumps 214, 214 .3 and 214.4. Optionally, the operation control is based on the pressure indication detected by the sensor 204.

[0114] In some embodiments, the controller 213 has a processor that calculates and transmits commands to the pumps 214, 214.3 and 214.4 based on and / or as a function of the sensor indication by the sensor 204. Optionally, the control is based on other sensing mechanisms ​ and / or based on input to the system 207 (e.g., commands entered by a user) It is something.

[0115] In some embodiments, system 207 may be configured to pump water and / or other fluids into system 207. 07. Also, optionally, system 20 7 may be, for example, water, other liquids, mixtures of liquids and gases, and / or pressurized gases or Optionally, the purge pump 214 includes a gaseous fluid source 211, such as carbon dioxide. Fluid under pressure is introduced into a purification portion of the system 207, for example, into the exhaust channel 203. The adjustment may be performed, for example, by the controller 213 based on input from the sensor 204 or other sources. It is triggered when an obstruction in the discharge channel 203 is detected. The controller 213 is connected to the pumps 214, 214.3 and 214.4 via a wired or wireless connection 205. Control .4.

[0116] In some embodiments of the system 207, the controller 213, the purge pump 214, Discharge pumps 214.3 and 214.4 and part of waste collection device 212W or All are grouped together at workstation 210. (Example Sensor Locations)

[0117] FIG. 2A shows a distal end of the exhaust channel 203 and positioned outside the channel. An exemplary sensor 204 is shown in this position. The sensor 204 in this position is When inserted into the colon 1, it directly measures the pressure within the colon 1. In some embodiments of the present invention, In this example, the sensor 204 is an electronic pressure sensor.

[0118] Now, refer to FIGS. 2B to 2D. FIGS. 2B to 2D show some exemplary additional or alternative sensors within the cleaning system 207 similar to FIG. 2A according to some embodiments of the present invention, and schematically show

[0119] their placement positions. In FIG. 2B, an exemplary sensor 204 is positioned at or near the distal end of the channel 203 and inside the channel 203. In this configuration, the sensor 204 measures and reports the pressure inside the distal portion of the channel 203. Optionally, the sensor 204 is connected to the controller 213 by a wired connection 205 through a connector 220. In some embodiments of the present invention, the wired connection 205 is routed either entirely or partially along the length within the channel 203. Also, the connection is routed proximally to the portion of the channel 203 that is inserted into the colon during use and is outside the channel 203 (e.g., through the connector 220). In some embodiments of the present invention, the connector 220 is an electrical connection. In some embodiments

[0120] of the present invention, the connection is wireless, such as by radio waves or optical coupling. In FIG. 2B, the exemplary sensor 204 is positioned inside the discharge channel 203 and at a distance 221 from the distal end of the channel 203. According to an embodiment, the distance 221 can be, for example, 0 mm, 1 mm, 2 mm, 5 mm, 10 mm, 20 mm, 30 mm, any distance between

[0121] these, or a longer or shorter distance. is positioned at or near an end. Three sensors, namely, a sensor 204A at the proximal end of channel 203, a sensor 204B of a sub-channel connecting discharge pump 214.4 to channel 203, and a sensor 204C of a sub-channel connecting purification pump 214.3 to discharge channel 203 are shown. Optionally, sensor 204 is arranged outside channel 203. In some cases, this enables direct sensing of the pressure inside the intestine. This is considered advantageous, for example, for sensing pressure to prevent excessive pressure in the intestine. Prevention of excessive pressure is achieved, for example, by stopping and / or reducing the feeding of gas or fluid (e.g., by perfusion pipe 201) into the intestine. In some embodiments, when the pressure is in an excessive pressure state, a state close thereto, and / or a (rising) state approaching it positively, the feeding by perfusion pipe 201 (optionally, an ejection feeding system), or other gas or fluid feeding systems such as a blowing pipe for maintaining intestinal inflation, is reduced and / or stopped. In some embodiments, the rising pressure approaching excessive pressure is determined based on the difference in pressure measured at at least two different times. Additionally or alternatively, the discharge rate is increased in a sensed excessive pressure state or a state close thereto. In some cases, this enables prevention of overexpansion while continuing without preventing washing. end, a sensor 204B of a sub-channel connecting discharge pump 214.4 to channel 203, and a sensor 204C of a sub-channel connecting purification pump 214.3 to discharge channel 203 are shown. Optionally, sensor 204 is arranged outside channel 203. In some cases, this enables direct sensing of the pressure inside the intestine. This is considered advantageous, for example, for sensing pressure to prevent excessive pressure in the intestine. Prevention of excessive pressure is achieved, for example, by stopping and / or reducing the feeding of gas or fluid (e.g., by perfusion pipe 201) into the intestine. In some embodiments, when the pressure is in an excessive pressure state, a state close thereto, and / or a (rising) state approaching it positively, the feeding by perfusion pipe 201 (optionally, an ejection feeding system), or other gas or fluid feeding systems such as a blowing pipe for maintaining intestinal inflation, is reduced and / or stopped. In some embodiments, the rising pressure approaching excessive pressure is determined based on the difference in pressure measured at at least two different times. Additionally or alternatively, the discharge rate is increased in a sensed excessive pressure state or a state close thereto. In some cases, this enables prevention of overexpansion while continuing without preventing washing. In some embodiments, the rising pressure approaching excessive pressure is determined based on the difference in pressure measured at at least two different times. Additionally or alternatively, the discharge rate is increased in a sensed excessive pressure state or a state close thereto. In some cases, this enables prevention of overexpansion while continuing without preventing washing. In some embodiments, when the pressure is in an excessive pressure state, a state close thereto, and / or a (rising) state approaching it positively, the feeding by perfusion pipe 201 (optionally, an ejection feeding system), or other gas or fluid feeding systems such as a blowing pipe for maintaining intestinal inflation, is reduced and / or stopped.

[0122] In some embodiments of the present invention, the sensor arrangements shown in FIGS. 2A - 2D and / or other drawings of the present application are combined. In some embodiments of the present invention, for example, position a single sensor 204 at a position shown in any of FIGS. 2A - 2D. This can be achieved. In some embodiments, for example, to obtain redundancy, a plurality of sensors can be positioned at the illustrated positions. Additionally and / or alternatively, sensors can be positioned at a plurality of positions as illustrated. (Exemplary Sensor Device)

[0123] Referring now to FIGS. 3A and 3B, FIGS. 3A and 3B schematically illustrate a colon cleansing system 207 having a remote pressure sensing module in accordance with some embodiments of the present invention.

[0124] In some embodiments of the present invention, the pump 214.5 can be driven to generate a positive pressure in the tube 202 extending from the pump 214.5 to the discharge of the discharge channel 203. Optionally, the pump 214.5 is positioned inside the workstation 210. Optionally, the tube 202 is connected to the discharge channel 203 via the head device 230. The working fluid delivered by the pump 214.5 is, for example, air, carbon dioxide, water, or other fluids.

[0125] A positive pressure can cause a flow 209 to occur in the tube 202. During colon cleansing, the flow 209 enters the distal end of the discharge channel 203 by suction from a discharge pump (not shown). From there, it is directed outside the system 207 along the length of the channel 203.

[0126] While the flow 209 continues without being blocked, no pressure accumulates in the tube 202 and the channel 203. The flow sensor or pressure sensor 204 senses the pressure or the velocity of the flow 209 and notifies the controller 213.

[0127] ​​​​​​​​​​​ In some embodiments of the present invention, when the discharge channel 203 is blocked or partially blocked by a mass or obstruction, the flow is not discharged from the channel 203 or, sufficiently discharged. Pressure buildup and / or a decrease in flow velocity occur in the channel 203 and / or the tube 202. The pressure / flow sensor 204 detects the change.

[0128] In some embodiments, the sensor 204 notifies the controller 213 of the change and / or the changing value. In some embodiments, the controller 213 determines the presence or absence of an obstruction from a drop of the flow to be detected or a pressure increase. Optionally, the controller 2 13 initiates a corrective action to remove the obstruction and restore the flow 209. This

[0129] is described in detail, for example, in connection with FIGS. 4A - 4F and FIGS. 5A - 5C.

[0130]

[0131]

[0132] ​​​​​​In some embodiments of the present invention, a protective film 234 having a barrier against a backflowing substance protects the sensor 204 from a possible backflow into the tube 202 by M. In some embodiments the film 234M is flexible enough that a pressure change can be transmitted through the film 234M to the chamber 234A in which the sensor 204 is disposed.

[0133] In some embodiments of the present invention, a check valve 232 prevents a backflow through the coupler 233. When the rearward pressure exceeds the forward pressure of the pump 214.5, the valve closes, thereby preventing the flow from contaminating the system by passing through the connector 233.

[0134] Now, referring to FIG. 3D. FIG. 3D is a diagram schematically showing a modification of the sensing module of the colon cleansing system 207 according to some exemplary embodiments of the present invention.

[0135] In some embodiments of the present invention, the flow generated by the pump 214.5 and flowing through the tube 202 is measured by a sensor (pressure and / or flow meter) 204A distal to the sensor 204. Optionally, the sensor (pressure and / or flow meter) 204A is placed at an independent workstation 201B. From there, it is connected to the connector 233, an additional flow tube 202A, and the outlet at the distal portion of the discharge channel 203.

[0136] An advantage considered in this embodiment is that the distance 231A between the sensor 204A in the channel 203 and the distal outlet of the tube 202 is small. This small distance is shorter than the sum of the distances 231A and 231B. Therefore, the pressure and / Or the flow display responds more accurately to obstructions in channel 203, thereby, it is believed that a more accurate sensor display is obtained.

[0137] Referring now to FIG. 3E. FIG. 3E schematically shows a variant of the sensing module of the colon cleansing system 207 according to some exemplary embodiments of the present invention.

[0138] In some embodiments of the present invention, the flow generated by pump 214.5 through tube 202 is measured by a sensor (and / or flow meter) 204A distal to sensor 204. Optionally, the sensor (pressure and / or flow meter) 204A is provided on an extension 240 of the workstation 210. Sensor 204A is connected through connector 233 to the outlet at the distal portion of the discharge channel 203.

[0139] An advantage contemplated in this embodiment is that the distance 241A between sensor 204A and the distal outlet of tube 202 of channel 203 is reduced. This small distance is shorter than the sum of distances 241A and 241B. Thus, the pressure and / or flow display from sensor 204A responds more accurately to obstructions in channel 203, thereby, it is believed that a more accurate sensor display is obtained.

[0140] FIGS. 2A - 3E show the sensor arrangements described above with respect to exemplary types and configurations of sensors including pressure sensing and flow sensing. In some embodiments of the present invention, one or more alternative types of sensors detect other parameters regarding substances inside or outside the system. By way of example, flow rate, particle sensing, temperature, Examples include H and / or osmotic pressure. In some embodiments of the present invention, a probe energy source suitable for the type of sensor, for example, a light source for an optical probe, is provided as appropriate.

[0141] According to an embodiment, the type of sensor is related to the operation of a colon cleansing system in the following exemplary aspects thereof. · The flow rate sensor detects the flow by velocity rather than volume. A low flow rate may indicate, for example, an obstruction in the lumen of the drainage channel. · The particle sensor provides particle information within the sensing region. According to an embodiment, the particle sensor is used, for example, to present a particle motility rate indicating a potential obstruction, the need for energetic disruption of the particles and / or to present an estimated particle size indicating a potential increase in the risk of obstruction, and / or or to present a value or an estimated value of the particle density indicating a potential increase in the risk of obstruction. is used. · The temperature sensor presents the temperature within the sensing region. A change in the sensed fluid temperature may indicate, for example, a long or short residence time of the fluid within the body. Optionally, the residence time within the body is represented by the magnitude until the temperature of the perfusion fluid starting from a temperature different from the body temperature becomes equal to the human body temperature. In some cases, information regarding the residence time of the fluid assists in determining a substantial flow within the system. · The conductivity sensor provides an indication of conductivity, such as the conductance of the excreted effluent. A change in conductance may indicate, for example, a change in the relative mixing ratio of gas and fluid in the effluent (e.g., foaming and / or indication of near total fluid discharge), and / or a potential change in the balance between the perfusion fluid and the intestinal fluid in the drainage channel. · Conductivity sensors, for example, display conductivity such as the conductance of the excreted excretory stream. Changes in conductance may indicate, for example, changes in the relative mixing ratio of gases and fluids in the excreted material (e.g., foaming and / or indication of near total fluid discharge), and / or potential changes in the balance between the perfusion fluid and the intestinal fluid in the drainage channel. · The pH sensor presents the ion concentration in the fluid. A change in pH indicates, for example, a possible change in the balance of the perfusion fluid and the intestinal fluid in the drainage channel. · The osmotic pressure sensor indicates the solute concentration in the fluid. A change in solute concentration indicates, for example, a possible change in the balance of the perfusion fluid and the intestinal fluid in the drainage channel. · The optical density sensor indicates the optical density of the fluid. Measurement of the optical density (and in particular turbidity) indicates, for example, the excrement content of the discharged excrement stream and / or the foaming of the fluid. A certain range of optical density indicates a high probability of the occurrence of obstacles. Specifically, the lower limit of such a range is due to the relative lack of particles in the channel, and the upper limit is defined by a sufficient turbidity such that it is shown that the particles are small and unlikely to form obstacles. Additionally or alternatively, a high optical density indicates a possibility of foaming. · The spectrum sensor indicates optical spectroscopic characteristics, for example, the optical density as a function of the light wavelength. Measurement of the spectroscopic characteristics reveals, for example, the concentration of one or more substances in the discharged perfusion substance. Optionally, the illumination, sensing and treatment are adjusted according to the hemoglobin characteristics. In some cases, the hemoglobin in the sensed discharged perfusion substance indicates bleeding, which is a serious complication that occurs at a low rate in colonoscopy. In some embodiments, a foaming fluid with dominant scattering having spectroscopic characteristics similar to the illumination light is distinguishable from a particle-containing fluid having spectroscopic characteristics of absorbing light according to the particle content. · The pump operation and / or the delivery effect parameter (e.g., the rotational speed or acceleration speed of the rotor) indicates, for example, the density of the substance transported by the pump. A decrease in the substance density indicates a possible foaming. ​ (Removal of Exemplary Obstructions)

[0142] Here, refer to FIGS. 4A to 4D. FIGS. 4A to 4D schematically show the removal of obstructions from the colon cleansing system discharge channel 203 according to some exemplary embodiments of the present invention. FIG.

[0143] During cleaning, the pump 214 supplies the irrigation fluid from the fluid container 211 to the colon 1 through the tube 201, and the pump 214.3 discharges the fecal matter irrigation fluid together with the irrigation fluid 2A to the collection container 212W through the tube 203.

[0144] In FIG. 4A, the discharge channel 203 is blocked or partially blocked by the fecal matter 206 covering the suction port. In FIG. 4C, the discharge channel 203 is blocked or partially blocked by the fecal matter 206 held and / or fitted inside.

[0145] When there is an obstruction in the tube 203, the pressure sensors 204 and / or 204A read the change in the pressure level and transmit such a change to the controller 213 via, for example, the cable 205. The controller 213 can determine based on the sensed data that there is an obstruction.

[0146] If it is determined that there is an obstruction, the controller 213 stops the operation of the pumps 214 and 214.3 and starts the pump 214.4. The pump 214.4 can supply liquid from the container 212A to the discharge tube 203 under reverse pressure and push out the obstruction 206 that is occurring or has occurred (FIGS. 4B and 4D).

[0147] It should be noted that as the evacuation channel 203 is inserted into the intestine, it may be compressed and / or partially The stricture may be caused by, for example, colonic structure and / or colonic location. This may result in kinking of the channel 203 and / or the passage of bodily organs or These narrowings may be due to large fecal particles passing through. In many cases, the pieces of material are too large to pass through and get caught and held in place. Thus, in some cases, fecal material 206 is initially blocked in one direction of travel, but is blocked in the other direction. However, there is room for particles to be removed in the reverse direction from the area where they cannot pass. If you take corrective action before there is a chance of hitting the obstacle, you will have time to remove the obstacle in the opposite direction. There is a land.

[0148] 4E-4F. The mass of material located at the sensor 204, 204A, and 204B of the exemplary system FIG. 1 is a diagram showing in detail how the controller Exemplary sensor indicators 250, 251, 252, 253 used in determining the state by 213 3 is shown.

[0149] Exemplary system sensors include pressure sensors at the distal, proximal, and middle of channel 203. The types of sensors include sensors 204, 204B, and 204A. and may vary depending on the embodiment.

[0150] The sensor display group 250 indicates system conditions other than flush, drain, or purge. A represents zero flow and pressure sensors 204, 204A and 204B are at zero difference from ambient pressure. Notify. If the flow meter is present (e.g., at the position of 204A), it may represent zero flow rate. It can be.

[0151] The sensor display group 253 includes exemplary displays representing a system state in which a normal discharge flow occurs during colon cleansing. Sensors 204, 204A, and 204B each represent -10 millibars, -200 millibars, and -300 millibars with respect to the ambient pressure. If the flow meter is present, it may represent the state of the flow. Also, two exemplary abnormal states are shown. When present, it may represent the state of the flow. It can be.

[0152] Also, two exemplary abnormal states are shown.

[0153] The sensor display group 251 includes exemplary displays representing a system state in which the tip of the discharge channel 203 is blocked by the fecal matter 206 (FIG. 4E). Sensors 204, 204A, and 204B all display a low pressure of -300 millibars with respect to the ambient pressure. If the flow meter is present, it may represent zero flow rate. It can be. When present, it may represent zero flow rate. It can be.

[0154] The sensor display group 252 includes exemplary displays representing a system state in which the inside of the discharge channel 203 is blocked by the fecal matter 206 (FIG. 4F). Sensors 204, 204A, and 204B each represent -10 millibars, -300 millibars, and -300 millibars with respect to the ambient pressure. If the flow meter is present, it may represent zero flow rate. It can be. When present, it may represent zero flow rate. It can be.

[0155] The blockage starts as a partial blockage and develops into a large-scale blockage and / or a large resistance to purification over time. In some embodiments of the present invention, sensing is performed at a frequency sufficient to detect intermediate pressure values between the blocked state and the unblocked state. Sampling rate It can be. and the non-blocked state is performed at a frequency sufficient to detect intermediate pressure values between the blocked state and the non-blocked state. Sampling rate The frequency is, for example, 5 Hz, 10 Hz, 20 Hz, 50 Hz, 100 Hz, 20 0 Hz, a frequency between these, or a higher or lower frequency. In some embodiments of the present invention, detection of the intermediate pressure value enables a determination that an obstruction is occurring . The determination can be made before the obstruction begins to significantly reduce the flow of the exhaust stream. In some embodiments of the present invention, the determination is made before a predetermined threshold value for the reduction in flow is reached, for example , 10%, 20%, 40%, 50%, 80%, or some other higher or lower threshold value for the reduction in flow is reached. In some embodiments of the present invention, the determination is made within a predetermined time interval after a predetermined threshold value for the reduction in flow is reached, for example, within 10 - 20 milliseconds after reaching at least 90 - 95% blockage, within 15 - 40 milliseconds after reaching at least 85 - 95% blockage , within 25 - 50 milliseconds after reaching at least 70 - 80% blockage , within 50 - 100 milliseconds after reaching at least 50% blockage, or within 50 - 100 milliseconds after reaching at least 90% blockage . An advantage that can be considered by early detection of an occurring obstruction is that an operation for purifying the exhaust lumen can be performed before the obstruction firmly fits into a fixed position . In some cases, a small (e.g., 15% of the lumen diameter) blockage state triggers a chain reaction leading to a complete blockage. For example , particles of 90% of the lumen diameter that could previously pass freely are blocked by contact with an obstruction of 20% of the lumen diameter and may themselves become an obstruction. At this stage, additional particles flowing in from behind may add to the occurring obstruction and the resistance to purification may increase , but if detected early, the obstruction can be easily reversed even if the blockage has already approached 100% . . . . . . can be caused to occur. Another advantage that can be considered by early detection of an interfering object during generation is that the operations required to remove small interfering objects can be minimally invasive, so that the inhibition of cleaning and discharge can be small. point. is.

[0156] Here, refer to FIGS. 5A to 5C. FIGS. 5A to 5C are diagrams schematically showing a single pump 214.1 operable as a discharge / purification pump according to an exemplary embodiment of the present invention. is. .

[0157] In some exemplary embodiments of the present invention, the pump 214.1 has a bidirectional pump function of delivering substances in both the distal and proximal directions according to its operating mode. have.

[0158] In some exemplary embodiments, the pump 214.1 draws excrement in the proximal direction and discharges it during the perfusion stage of colon cleansing. In some embodiments, when the controller 213 determines to purify the discharge channel 203, it reverses the delivery direction of the pump 214.1 to generate a pressure and possibly a flow towards the distal end. The determination is made, for example, based on the determination of the interfering object 206 as in the case of FIG. 5A and / or in response to a manual instruction by the user. The pressure and / or flow towards the distal end can press the determined interfering object 206 and expel it from within the channel 203 (FIG. 5B or FIG. 5C). and discharges it during the perfusion stage of colon cleansing. In some embodiments, when the controller 213 determines to purify the discharge channel 203, it reverses the delivery direction of the pump 214.1 to generate a pressure and possibly a flow towards the distal end. The determination is made, for example, based on the determination of the interfering object 206 as in the case of FIG. 5A and / or in response to a manual instruction by the user. The pressure and / or flow towards the distal end can press the determined interfering object 206 and expel it from within the channel 203 (FIG. 5B or FIG. 5C). direction to generate a pressure and possibly a flow towards the distal end. The determination is made, for example, based on the determination of the interfering object 206 as in the case of FIG. 5A and / or in response to a manual instruction by the user. The pressure and / or flow towards the distal end can press the determined interfering object 206 and expel it from within the channel 203 (FIG. 5B or FIG. 5C). direction to generate a pressure and possibly a flow towards the distal end. The determination is made, for example, based on the determination of the interfering object 206 as in the case of FIG. 5A and / or in response to a manual instruction by the user. The pressure and / or flow towards the distal end can press the determined interfering object 206 and expel it from within the channel 203 (FIG. 5B or FIG. 5C). For example, the determination of the interfering object 206 as in the case of FIG. 5A and / or in response to a manual instruction by the user. is made according to. The pressure and / or flow towards the distal end can press the determined interfering object 206 and expel it from within the channel 203 (FIG. 5B or FIG. 5C).

[0159] Optionally, the purification pulse is short, for example, 50 milliseconds, 100 milliseconds, 200 milliseconds, 500 milliseconds, 1000 milliseconds, 2000 milliseconds, any time between these, or is longer or shorter. To prevent a large amount of substance from being pushed back into the colon, the purification is prevented. It is considered effective not to continue longer than the time required for pest control. Optionally , suction pulses and purification pulses are alternately applied. The total number of pulses is, for example, 2 pa lses, 4 pulses, 8 pulses, 20 pulses, 40 pulses, 80 pulses, any number between these , or a larger or smaller number of pulses. It is considered effective to apply a series of pulses to oscillate and / or break up the interfering substance. In some cases, a series of pulses can break up the mass and remove the interfering substance from the channel. For some embodiments, the purification substance container 212 contains both the gas 260A and the fluid 260W. In some embodiments, the tube 203W can be positioned to selectively draw in the gas 260A or the fluid 260W during the purification operation. For example, the tube 20 3W in FIG. 5B is pushed down into the fluid 260W to extract the fluid and pushed up into the gas (e.g., air) 260A to extract the gas. Optionally, the container 212 can be inverted, for example

[0160] it can be held by hand. With an upward-facing container 212 as in FIG. 5B, for example, the purification gas 260A can be extracted. Also, with an inverted container 212 as in FIG. 5C, the purification fluid 260W can be extracted. In some embodiments, the vent 261 of the container 212 allows venting of the accumulated gas and / or intake into the container 212 during operation as needed. In some embodiments, a gas input is provided in the channel 203. As a possibility, the tube 203W in FIG. 5B is pushed down into the fluid 260W to extract the fluid and pushed up into the gas (e.g., air) 260A to extract the gas. Optionally, the container 212 can be inverted, for example it can be held by hand. With an upward-facing container 212 as in FIG. 5B, for example, the purification gas 260A can be extracted. Also, with an inverted container 212 as in FIG. 5C, the purification fluid 260W can be extracted. it can be held by hand. With an upward-facing container 212 as in FIG. 5B, for example, the purification gas 260A can be extracted. Also, with an inverted container 212 as in FIG. 5C, the purification fluid 260W can be extracted. In some embodiments, the vent 261 of the container 212 allows venting of the accumulated gas and / or intake into the container 212 during operation as needed. In some embodiments, a gas input is provided in the channel 203. As a possibility,

[0161] In some embodiments, the vent 261 of the container 212 allows venting of the accumulated gas and / or intake into the container 212 during operation as needed. In some embodiments, a gas input is provided in the channel 203. As a possibility,

[0162] In some embodiments, a gas input is provided in the channel 203. As a possibility, Mixtures of liquids and gases are provided, for example, in ratios of 10:1, 4:1, 2:1, 1:1, 1:2, any ratio between these, or other higher or lower ratios. It is considered effective to mix the gas and fluid to more effectively decompose the tissue mass. It is known from the applicant's experiments that such gas / liquid mixtures can be effective in removing and / or decomposing the clumped fecal matter. (Other State Judgments and Responses)

[0163] In the examples described above, it is shown how the controller makes state judgments based on a combination of data from a group of sensors and / or a single sensor. When using a group of pressure sensors, the presence and approximate location of obstructions can be determined. When using a single flow sensor, the presence of obstructions can be determined. An indication signal is sent by the controller 213 according to the determined state.

[0164] In some embodiments of the present invention, the state judgment causes any one of several optionally ranked responses from the controller 213. The response is determined according to the sensed data and / or the details of the history of the sensed data.

[0165] In some embodiments, the corrective actions performed by the controller vary according to the determination of the position of the obstruction. Optionally, the distal end obstruction removal routine includes an instantaneous stop of the discharge. While changing the discharge pressure, a water wash jet is fed from the irrigation port to push the obstruction out from the tip. The resulting advantage is faster cleaning because it is not necessary to reverse the already discharged particles and discharge them a second time. However, ​​​​​​​​​​​​​ Very inner obstructions are not affected by the distal end water flushing jet. In such cases, it is considered preferable to immediately reverse the flow direction in the discharge channel.

[0166] In some embodiments of the present invention, the severity of the obstruction is determined using sensor displays. For example, partial obstructions within the discharge channel 203 can cause a display intermediate between displays 253 and 252. In some embodiments, the determination of the intermediate level of the obstruction is a potential determination state of the system. Optionally, the controller determines whether to initiate a purification operation based on a threshold value of the severity of the obstruction. In some embodiments, the threshold value can be selected by the user, thereby allowing a balance to be struck between the discharge rate and the sensitivity to potential obstructions. The advantage that can be considered by making the threshold value adjustable is that it can be adjusted according to various states of the intestine. For example, the discharge period of the discharge / purification operation cycle can be set to be as long as possible for a specific patient's colon condition without risking the obstruction becoming unrecoverable.

[0167] Another state that can be determined in some embodiments of the present invention is the rate at which obstructions occur. The determination by the controller whether to operate on a partial obstruction is optionally affected by the rate of increase of the obstruction. For example, a rapidly occurring pressure change can indicate the occurrence of a solid obstruction. Optionally, an initial solid obstruction is immediately purified even if the actual flow reduction is slight. Conversely, a slowly occurring pressure change is optionally allowed to rise until a higher level of obstruction occurs. This is, for example, the case with the discharge pipe. Consider it related to normal operation during insertion, or the possibility of relaxation or automatic adjustment It can be determined that it is high. Optionally, this is a high-speed variation with reduced sensitivity to exclude, for example, measurement noise and damped waves Optionally, there are multiple state categories that can be determined by the controller 2 13. In some embodiments, the con Troller 213 ignores, for example, very small changes and operates quickly in response to somewhat gradual or large changes, and sets a high threshold for response to gradual changes

[0168] The use of a pressure sensor in some embodiments of the present invention optionally enables the determination of a system state including obstructions and obstructions in progress (such as the position, severity and / or generation rate, etc ) as described in the examples above. To perform these and related sensing functions, In some embodiments of the present invention, a pressure sensor is typically used. In some Embodiments of the present invention, other types of sensors and / or sensor systems are present on, near or inside the tip of the discharge channel or The discharge channel. Such additional inputs are optionally made in the form of further state determinations and can affect system operation

[0169] In some embodiments of the present invention, the insertion tube has a sensor suitable for sensing the presence or absence of fluid The fluid sensor is, for example, a pH sensor, an osmotic pressure sensor and / or a conductivity sensor In some embodiments, the fluid sensor is arranged in the insertion tube of the colon irrigation system to Detect the fluid around the distal end of the insertion tube. Optionally, this state determination automatically initiates a fluid discharge routine for removing the fluid At this time, at the same time, the supply of the perfusion fluid ​​​It may or may not be performed.

[0170] In some embodiments, the optical sensor senses the flow of a substance by an optical flow in the vicinity of the sensor. According to an embodiment, an appropriate illumination source for the sensor is provided. In some embodiments, the optical sensor notifies spectral information, thereby enabling determination of information regarding the composition of the excreted substance. For example, the presence or absence of blood in the excreted substance is potentially indicated by an excreted substance having spectral characteristics of hemoglobin. An advantage that can be considered by detecting blood in the excreted substance is that bleeding, which is a serious complication in colonoscopy, can be detected. An optional operation instructed by the controller when unexpected bleeding is detected is to stop the vacuum to the colon and / or present an auditory or visual warning.

[0171] In some embodiments of the present invention, the optical sensor indicates to the controller the excreted substance content in the discharged fluid. The excreted substance content is measured, for example, by turbidity and / or optical density representing a solute, particle content, and / or particle size. In some embodiments of the present invention, the displayed excreted substance content has a threshold value, and if it is less than the threshold value, the fluid is regarded as purified. Optionally, when the threshold state (e.g., cleanliness) is satisfied and / or when the threshold state is satisfied for a preset time, the perfusion routine and the discharge routine are terminated. Optionally, the perfusion routine and / or the discharge routine are started when the field of view through the colonoscope is determined to be unclear. In some embodiments, the optical sensor notifies spectral information, thereby enabling determination of information regarding the composition of the excreted substance. For example, the presence or absence of blood in the excreted substance is potentially indicated by an excreted substance having spectral characteristics of hemoglobin. An advantage that can be considered by detecting blood in the excreted substance is that bleeding, which is a serious complication in colonoscopy, can be detected. An optional operation instructed by the controller when unexpected bleeding is detected is to stop the vacuum to the colon and / or present an auditory or visual warning. In some embodiments of the present invention, the optical sensor indicates to the controller the excreted substance content in the discharged fluid. The excreted substance content is measured, for example, by turbidity and / or optical density representing a solute, particle content, and / or particle size. In some embodiments of the present invention, the displayed excreted substance content has a threshold value, and if it is less than the threshold value, the fluid is regarded as purified. Optionally, when the threshold state (e.g., cleanliness) is satisfied and / or when the threshold state is satisfied for a preset time, the perfusion routine and the discharge routine are terminated. Optionally, the perfusion routine and / or the discharge routine are started when the field of view through the colonoscope is determined to be unclear. In some embodiments of the present invention, the optical sensor indicates to the controller the excreted substance content in the discharged fluid. The excreted substance content is measured, for example, by turbidity and / or optical density representing a solute, particle content, and / or particle size. In some embodiments of the present invention, the displayed excreted substance content has a threshold value, and if it is less than the threshold value, the fluid is regarded as purified. Optionally, when the threshold state (e.g., cleanliness) is satisfied and / or when the threshold state is satisfied for a preset time, the perfusion routine and the discharge routine are terminated. Optionally, the perfusion routine and / or the discharge routine are started when the field of view through the colonoscope is determined to be unclear. In some embodiments of the present invention, the optical sensor indicates to the controller the excreted substance content in the discharged fluid. The excreted substance content is measured, for example, by turbidity and / or optical density representing a solute, particle content, and / or particle size. In some embodiments of the present invention, the displayed excreted substance content has a threshold value, and if it is less than the threshold value, the fluid is regarded as purified. Optionally, when the threshold state (e.g., cleanliness) is satisfied and / or when the threshold state is satisfied for a preset time, the perfusion routine and the discharge routine are terminated. Optionally, the perfusion routine and / or the discharge routine are started when the field of view through the colonoscope is determined to be unclear. In some embodiments of the present invention, the optical sensor indicates to the controller the excreted substance content in the discharged fluid. The excreted substance content is measured, for example, by turbidity and / or optical density representing a solute, particle content, and / or particle size. In some embodiments of the present invention, the displayed excreted substance content has a threshold value, and if it is less than the threshold value, the fluid is regarded as purified. Optionally, when the threshold state (e.g., cleanliness) is satisfied and / or when the threshold state is satisfied for a preset time, the perfusion routine and the discharge routine are terminated. Optionally, the perfusion routine and / or the discharge routine are started when the field of view through the colonoscope is determined to be unclear. In some embodiments of the present invention, the optical sensor indicates to the controller the excreted substance content in the discharged fluid. The excreted substance content is measured, for example, by turbidity and / or optical density representing a solute, particle content, and / or particle size. In some embodiments of the present invention, the displayed excreted substance content has a threshold value, and if it is less than the threshold value, the fluid is regarded as purified. Optionally, when the threshold state (e.g., cleanliness) is satisfied and / or when the threshold state is satisfied for a preset time, the perfusion routine and the discharge routine are terminated. Optionally, the perfusion routine and / or the discharge routine are started when the field of view through the colonoscope is determined to be unclear.

[0172] In some embodiments of the present invention, the optical sensor indicates to the controller the excreted substance content in the discharged fluid. The excreted substance content is measured, for example, by turbidity and / or optical density representing a solute, particle content, and / or particle size. In some embodiments of the present invention, the displayed excreted substance content has a threshold value, and if it is less than the threshold value, the fluid is regarded as purified. Optionally, when the threshold state (e.g., cleanliness) is satisfied and / or when the threshold state is satisfied for a preset time, the perfusion routine and the discharge routine are terminated. Optionally, the perfusion routine and / or the discharge routine are started when the field of view through the colonoscope is determined to be unclear. In some embodiments of the present invention, the optical sensor indicates to the controller the excreted substance content in the discharged fluid. The excreted substance content is measured, for example, by turbidity and / or optical density representing a solute, particle content, and / or particle size. In some embodiments of the present invention, the displayed excreted substance content has a threshold value, and if it is less than the threshold value, the fluid is regarded as purified. Optionally, when the threshold state (e.g., cleanliness) is satisfied and / or when the threshold state is satisfied for a preset time, the perfusion routine and the discharge routine are terminated. Optionally, the perfusion routine and / or the discharge routine are started when the field of view through the colonoscope is determined to be unclear. In some embodiments of the present invention, the optical sensor indicates to the controller the excreted substance content in the discharged fluid. The excreted substance content is measured, for example, by turbidity and / or optical density representing a solute, particle content, and / or particle size. In some embodiments of the present invention, the displayed excreted substance content has a threshold value, and if it is less than the threshold value, the fluid is regarded as purified. Optionally, when the threshold state (e.g., cleanliness) is satisfied and / or when the threshold state is satisfied for a preset time, the perfusion routine and the discharge routine are terminated. Optionally, the perfusion routine and / or the discharge routine are started when the field of view through the colonoscope is determined to be unclear. In some embodiments of the present invention, the optical sensor indicates to the controller the excreted substance content in the discharged fluid. The excreted substance content is measured, for example, by turbidity and / or optical density representing a solute, particle content, and / or particle size. In some embodiments of the present invention, the displayed excreted substance content has a threshold value, and if it is less than the threshold value, the fluid is regarded as purified. Optionally, when the threshold state (e.g., cleanliness) is satisfied and / or when the threshold state is satisfied for a preset time, the perfusion routine and the discharge routine are terminated. Optionally, the perfusion routine and / or the discharge routine are started when the field of view through the colonoscope is determined to be unclear. In some embodiments of the present invention, the optical sensor indicates to the controller the excreted substance content in the discharged fluid. The excreted substance content is measured, for example, by turbidity and / or optical density representing a solute, particle content, and / or particle size. In some embodiments of the present invention, the displayed excreted substance content has a threshold value, and if it is less than the threshold value, the fluid is regarded as purified. Optionally, when the threshold state (e.g., cleanliness) is satisfied and / or when the threshold state is satisfied for a preset time, the perfusion routine and the discharge routine are terminated. Optionally, the perfusion routine and / or the discharge routine are started when the field of view through the colonoscope is determined to be unclear. In some embodiments of the present invention, the optical sensor indicates to the controller the excreted substance content in the discharged fluid. The excreted substance content is measured, for example, by turbidity and / or optical density representing a solute, particle content, and / or particle size. In some embodiments of the present invention, the displayed excreted substance content has a threshold value, and if it is less than the threshold value, the fluid is regarded as purified. Optionally, when the threshold state (e.g., cleanliness) is satisfied and / or when the threshold state is satisfied for a preset time, the perfusion routine and the discharge routine are terminated. Optionally, the perfusion routine and / or the discharge routine are started when the field of view through the colonoscope is determined to be unclear. In some embodiments of the present invention, the optical sensor indicates to the controller the excreted substance content in the discharged fluid. The excreted substance content is measured, for example, by turbidity and / or optical density representing a solute, particle content, and / or particle size. In some embodiments of the present invention, the displayed excreted substance content has a threshold value, and if it is less than the threshold value, the fluid is regarded as purified. Optionally, when the threshold state (e.g., cleanliness) is satisfied and / or when the threshold state is satisfied for a preset time, the perfusion routine and the discharge routine are terminated. Optionally, the perfusion routine and / or the discharge routine are started when the field of view through the colonoscope is determined to be unclear. In some embodiments of the present invention, the optical sensor indicates to the controller the excreted substance content in the discharged fluid. The excreted substance content is measured, for example, by turbidity and / or optical density representing a solute, particle content, and / or particle size. In some embodiments of the present invention, the displayed excreted substance content has a threshold value, and if it is less than the threshold value, the fluid is regarded as purified. Optionally, when the threshold state (e.g., cleanliness) is satisfied and / or when the threshold state is satisfied for a preset time, the perfusion routine and the discharge routine are terminated. Optionally, the perfusion routine and / or the discharge routine are started when the field of view through the colonoscope is determined to be unclear.

[0173] In some embodiments, the density (opacity), turbidity, and / or conductance of the delivered fluid indicates the presence or absence of foam. A sensed indication that indicates the need for cleaning, and optionally, the parameters of the cleaning itself, may be different when dealing with foamy and non-foamy effluents. For example, a pressure change indicating a foam obstruction is thought to be different because the compressibility of foam is higher than that of liquid. Also, for example, in some embodiments, the cleaning of foam obstructions in the presence of a foaming substance includes an extended cleaning cycle. Optionally, the extended cycle is long enough to send non-foamy substances distally, thereby performing a more effective cleaning operation. In some embodiments, the density (opacity), turbidity, and / or conductance of the delivered fluid indicates the presence or absence of foam. A sensed indication that indicates the need for cleaning, and optionally, the parameters of the cleaning itself, may be different when dealing with foamy and non-foamy effluents. For example, a pressure change indicating a foam obstruction is thought to be different because the compressibility of foam is higher than that of liquid. Also, for example, in some embodiments, the cleaning of foam obstructions in the presence of a foaming substance includes an extended cleaning cycle. Optionally, the extended cycle is long enough to send non-foamy substances distally, thereby performing a more effective cleaning operation. In some embodiments, the density (opacity), turbidity, and / or conductance of the delivered fluid indicates the presence or absence of foam. A sensed indication that indicates the need for cleaning, and optionally, the parameters of the cleaning itself, may be different when dealing with foamy and non-foamy effluents. For example, a pressure change indicating a foam obstruction is thought to be different because the compressibility of foam is higher than that of liquid. Also, for example, in some embodiments, the cleaning of foam obstructions in the presence of a foaming substance includes an extended cleaning cycle. Optionally, the extended cycle is long enough to send non-foamy substances distally, thereby performing a more effective cleaning operation. In some embodiments, the density (opacity), turbidity, and / or conductance of the delivered fluid indicates the presence or absence of foam. A sensed indication that indicates the need for cleaning, and optionally, the parameters of the cleaning itself, may be different when dealing with foamy and non-foamy effluents. For example, a pressure change indicating a foam obstruction is thought to be different because the compressibility of foam is higher than that of liquid. Also, for example, in some embodiments, the cleaning of foam obstructions in the presence of a foaming substance includes an extended cleaning cycle. Optionally, the extended cycle is long enough to send non-foamy substances distally, thereby performing a more effective cleaning operation. In some embodiments, the density (opacity), turbidity, and / or conductance of the delivered fluid indicates the presence or absence of foam. A sensed indication that indicates the need for cleaning, and optionally, the parameters of the cleaning itself, may be different when dealing with foamy and non-foamy effluents. For example, a pressure change indicating a foam obstruction is thought to be different because the compressibility of foam is higher than that of liquid. Also, for example, in some embodiments, the cleaning of foam obstructions in the presence of a foaming substance includes an extended cleaning cycle. Optionally, the extended cycle is long enough to send non-foamy substances distally, thereby performing a more effective cleaning operation. In some embodiments, the density (opacity), turbidity, and / or conductance of the delivered fluid indicates the presence or absence of foam. A sensed indication that indicates the need for cleaning, and optionally, the parameters of the cleaning itself, may be different when dealing with foamy and non-foamy effluents. For example, a pressure change indicating a foam obstruction is thought to be different because the compressibility of foam is higher than that of liquid. Also, for example, in some embodiments, the cleaning of foam obstructions in the presence of a foaming substance includes an extended cleaning cycle. Optionally, the extended cycle is long enough to send non-foamy substances distally, thereby performing a more effective cleaning operation. In some embodiments, the density (opacity), turbidity, and / or conductance of the delivered fluid indicates the presence or absence of foam. A sensed indication that indicates the need for cleaning, and optionally, the parameters of the cleaning itself, may be different when dealing with foamy and non-foamy effluents. For example, a pressure change indicating a foam obstruction is thought to be different because the compressibility of foam is higher than that of liquid. Also, for example, in some embodiments, the cleaning of foam obstructions in the presence of a foaming substance includes an extended cleaning cycle. Optionally, the extended cycle is long enough to send non-foamy substances distally, thereby performing a more effective cleaning operation. In some embodiments, the density (opacity), turbidity, and / or conductance of the delivered fluid indicates the presence or absence of foam. A sensed indication that indicates the need for cleaning, and optionally, the parameters of the cleaning itself, may be different when dealing with foamy and non-foamy effluents. For example, a pressure change indicating a foam obstruction is thought to be different because the compressibility of foam is higher than that of liquid. Also, for example, in some embodiments, the cleaning of foam obstructions in the presence of a foaming substance includes an extended cleaning cycle. Optionally, the extended cycle is long enough to send non-foamy substances distally, thereby performing a more effective cleaning operation.

[0174] In some embodiments of the present invention, a history of the excretory content discharged during the process is recorded and made available for online publication and / or subsequent retrieval. Optionally, the search data is in the form of a report. Optionally, the notified excretory content is a function of time and / or intestinal location. Optionally, the excretory content is notified as an integrated value. Using a highly reliable colon cleansing system in colonoscopy may allow for changing the procedure for cleaning the patient's intestine (e.g., to be less invasive). In some embodiments of the present invention, a history of the excretory content discharged during the process is recorded and made available for online publication and / or subsequent retrieval. Optionally, the search data is in the form of a report. Optionally, the notified excretory content is a function of time and / or intestinal location. Optionally, the excretory content is notified as an integrated value. Using a highly reliable colon cleansing system in colonoscopy may allow for changing the procedure for cleaning the patient's intestine (e.g., to be less invasive). In some embodiments of the present invention, a history of the excretory content discharged during the process is recorded and made available for online publication and / or subsequent retrieval. Optionally, the search data is in the form of a report. Optionally, the notified excretory content is a function of time and / or intestinal location. Optionally, the excretory content is notified as an integrated value. Using a highly reliable colon cleansing system in colonoscopy may allow for changing the procedure for cleaning the patient's intestine (e.g., to be less invasive). In some embodiments of the present invention, a history of the excretory content discharged during the process is recorded and made available for online publication and / or subsequent retrieval. Optionally, the search data is in the form of a report. Optionally, the notified excretory content is a function of time and / or intestinal location. Optionally, the excretory content is notified as an integrated value. Using a highly reliable colon cleansing system in colonoscopy may allow for changing the procedure for cleaning the patient's intestine (e.g., to be less invasive). In some embodiments of the present invention, a history of the excretory content discharged during the process is recorded and made available for online publication and / or subsequent retrieval. Optionally, the search data is in the form of a report. Optionally, the notified excretory content is a function of time and / or intestinal location. Optionally, the excretory content is notified as an integrated value. Using a highly reliable colon cleansing system in colonoscopy may allow for changing the procedure for cleaning the patient's intestine (e.g., to be less invasive). In some embodiments of the present invention, a history of the excretory content discharged during the process is recorded and made available for online publication and / or subsequent retrieval. Optionally, the search data is in the form of a report. Optionally, the notified excretory content is a function of time and / or intestinal location. Optionally, the excretory content is notified as an integrated value. Using a highly reliable colon cleansing system in colonoscopy may allow for changing the procedure for cleaning the patient's intestine (e.g., to be less invasive). In some embodiments, one or more typical cleaning steps, for example, cleaning can be performed without undergoing a fast or collecting liquids according to instructions. In some embodiments, the operation is performed without a prepress, i.e., without going through a prior colon cleansing step. Providing feedback on the effectiveness of a particular pre-examination cleaning step can be useful for evaluating the effectiveness of alternative procedures. Additionally and / or alternatively, an unacceptably large amount of excretory matter in the patient's colon In some embodiments, one or more typical cleaning steps, for example, cleaning can be performed without undergoing a fast or collecting liquids according to instructions. In some embodiments, the operation is performed without a prepress, i.e., without going through a prior colon cleansing step. Providing feedback on the effectiveness of a particular pre-examination cleaning step can be useful for evaluating the effectiveness of alternative procedures. Additionally and / or alternatively, an unacceptably large amount of excretory matter in the patient's colon In some embodiments, one or more typical cleaning steps, for example, cleaning can be performed without undergoing a fast or collecting liquids according to instructions. In some embodiments, the operation is performed without a prepress, i.e., without going through a prior colon cleansing step. Providing feedback on the effectiveness of a particular pre-examination cleaning step can be useful for evaluating the effectiveness of alternative procedures. Additionally and / or alternatively, an unacceptably large amount of excretory matter in the patient's colon In some embodiments, one or more typical cleaning steps, for example, cleaning can be performed without undergoing a fast or collecting liquids according to instructions. In some embodiments, the operation is performed without a prepress, i.e., without going through a prior colon cleansing step. Providing feedback on the effectiveness of a particular pre-examination cleaning step can be useful for evaluating the effectiveness of alternative procedures. Additionally and / or alternatively, an unacceptably large amount of excretory matter in the patient's colon In some embodiments, one or more typical cleaning steps, for example, cleaning can be performed without undergoing a fast or collecting liquids according to instructions. In some embodiments, the operation is performed without a prepress, i.e., without going through a prior colon cleansing step. Providing feedback on the effectiveness of a particular pre-examination cleaning step can be useful for evaluating the effectiveness of alternative procedures. Additionally and / or alternatively, an unacceptably large amount of excretory matter in the patient's colon Use the target display as a basis for corrective actions and / or stopping the treatment in the treatment of the content is also possible.

[0175] In some embodiments of the present invention, a sensor indicating a state far from the discharge channel and / or the determination is utilized by the controller 213.

[0176] In some embodiments, the sensed data and / or status display are provided to the colon cleansing system from other systems or subsystems, such as a colonoscope or a clinical monitoring device. Optionally, even if these data and / or status displays directly initiate and / or stop the cleansing routine, additional inputs may be provided to the controller for making operational determinations. The data and displays are exchanged, for example, by cables, optical couplings, wireless, and / or other standard or proprietary communication methods between the colon cleansing system and its other systems.

[0177] In some embodiments of the present invention, optionally, for example, an automatic determination display of the presence or absence of a substance that obscures the field of view of the colonoscope is provided to the controller 213. Optionally, when such a display is received, the cleansing routine is initiated. (Exemplary cleansing routine)

[0178] Here, refer to FIG. 6. FIG. 6 is a flowchart briefly showing an exemplary colon cleansing method including the detection and purification of contaminants according to some exemplary embodiments of the present invention. The method is implemented, for example, during an ongoing colonoscopy. For reference numerals not shown in FIG. 6, refer to the above drawings, such as FIGS. 4A - 4F. In this P214.4 is treated as a vacuum source (to move substances in the proximal direction), and pump 214.3 is treated as a pump to move substances in the distal direction in the discharge channel 203.

[0179] According to some exemplary embodiments of the present invention, in step 1008, a determination is made to start the cleaning routine. The determination is made, for example, based on the value of the elapsed time, an instruction by an operator of the cleaning system, and / or the determined system state. Optionally , for example, when liquid stains and / or obscurity of the field of view are determined, the cleaning routine is started.

[0180] According to some exemplary embodiments, in step 1010, the cleaning routine is started. The liquid perfused into the colon is supplied, for example, by pump 214 through perfusion pipe 201 . Also, for example, suction of the discharge channel 20 3 is performed by pump 214.4 or other vacuum source. By suction, fecal substances dissolved or suspended in the perfusate move in the proximal direction from the colon 1 in the channel 203. Optionally, the excrement is collected by the excrement collection device 212A. In some embodiments, the relative balance of suction and perfusion is controlled by the controller 213. The balance is, for example, maintained at equal amounts, or alternatively, finally prevent overpressure or fluid adhesion by suction. Optionally , the control is adjusted based on sensor data under monitoring.

[0181] According to some embodiments, in step 1012, one or more system state determinations are made . For example, the sensors and sensing modules described in connection with FIGS. 2A-4F or other parts of this specification notify the controller 213 of pressure data and / or flow data . The controller 213 makes one or more state determinations based on the notified data. Note . It should be noted that the controller 213 is optionally realized in a distributed form. . For example, some sensing, state determination, and control (e.g., sensing of shutdown in a fault state) can be incorporated into the pump. Other state determinations and controls are optionally . aggregated in the CPU, FPGA, or other logic circuits of the colon cleansing system.

[0182] . According to some embodiments, in step 1013, a determination of whether to continue perfusion is made. The controller 213 determines, for example, whether the safety limit point of the pressure is maintained, whether a manual instruction to stop perfusion has been issued, and / or whether a preset perfusion time has elapsed. If a determination to stop perfusion is made, in step 1014, perfusion is stopped until the next start.

[0183] . According to some embodiments, in step 1014, perfusion is aborted.

[0184] . According to some embodiments, in step 1015, a determination of whether to start purification is made. The controller 213 determines, for example, whether the state of the flow and / or pressure is within the range of parameters suitable for the continuation of the cleaning process. The pressure suitable for the start of purification is, for example, the pressure determined to be within the range of the safety pressure limit point for the pressure in the colon. The safety pressure conditions are, for example, less than 90 - 110 millimeters of mercury, less than 100 - 150 millimeters of mercury, less than 1 40 - 160 millimeters of mercury, or less than 150 - 200 millimeters of mercury. Additionally and / or alternatively, the controller 213 determines whether the elapsed time of perfusion before purification is Determine whether it is within a preset perfusion time and / or whether a manual purification instruction has been issued. When the purification determination is made, the purification routine is started in step 1016. Otherwise, the cleaning continues in step 1010. In some embodiments, in step 1016, the controller 213 instructs the suction pump source 214.4 to stop. Optionally, the perfusion pump 214 is also stopped. In some embodiments, in step 1018, the controller 213 activates the purification pump 214.3. The purification pump 214.3 delivers water or other liquid distally into the channel 203 from the source 211. In some cases, this flushes out obstructions. In some embodiments, the purification continues until the determination of obstructions is cancelled and / or until a preset time has elapsed. The preset time can be, for example, 50 milliseconds, 100 milliseconds, 200 milliseconds, 500 milliseconds, 1000 milliseconds, any time in between, or a longer or shorter time. In some embodiments, if a potentially dangerous pressure level is determined in the colon, the purification routine is stopped (e.g., the purification pump 214.3 is stopped). In some embodiments, the duration of the purification routine is determined by input from the operator of the device. In some embodiments, the purification includes a series of subdivided purification operations and / or purification stages as described below.

[0185] In some embodiments, in step 1016, the controller 213 instructs the suction pump source 214.4 to stop. Optionally, the perfusion pump 214 is also stopped. In some embodiments, in step 1018, the controller 213 activates the purification pump 214.3. The purification pump 214.3 delivers water or other liquid distally into the channel 203 from the source 211. In some cases, this flushes out obstructions. In some embodiments, the purification continues until the determination of obstructions is cancelled and / or until a preset time has elapsed. The preset time can be, for example, 50 milliseconds, 100 milliseconds, 200 milliseconds, 500 milliseconds, 1000 milliseconds, any time in between, or a longer or shorter time. In some embodiments, if a potentially dangerous pressure level is determined in the colon, the purification routine is stopped (e.g., the purification pump 214.3 is stopped). In some embodiments, the duration of the purification routine is determined by input from the operator of the device. In some embodiments, the purification includes a series of subdivided purification operations and / or purification stages as described below. In some embodiments, in step 1018, the controller 213 activates the purification pump 214.3. The purification pump 214.3 delivers water or other liquid distally into the channel 203 from the source 211. In some cases, this flushes out obstructions. In some embodiments, the purification continues until the determination of obstructions is cancelled and / or until a preset time has elapsed. The preset time can be, for example, 50 milliseconds, 100 milliseconds, 200 milliseconds, 500 milliseconds, 1000 milliseconds, any time in between, or a longer or shorter time. In some embodiments, if a potentially dangerous pressure level is determined in the colon, the purification routine is stopped (e.g., the purification pump 214.3 is stopped). In some embodiments, the duration of the purification routine is determined by input from the operator of the device. In some embodiments, the purification includes a series of subdivided purification operations and / or purification stages as described below.

[0186] In some embodiments, in step 1018, the controller 213 activates the purification pump 214.3. The purification pump 214.3 delivers water or other liquid distally into the channel 203 from the source 211. In some cases, this flushes out obstructions. In some embodiments, the purification continues until the determination of obstructions is cancelled and / or until a preset time has elapsed. The preset time can be, for example, 50 milliseconds, 100 milliseconds, 200 milliseconds, 500 milliseconds, 1000 milliseconds, any time in between, or a longer or shorter time. In some embodiments, if a potentially dangerous pressure level is determined in the colon, the purification routine is stopped (e.g., the purification pump 214.3 is stopped). In some embodiments, the duration of the purification routine is determined by input from the operator of the device. In some embodiments, the purification includes a series of subdivided purification operations and / or purification stages as described below. In some embodiments, in step 1018, the controller 213 activates the purification pump 214.3. The purification pump 214.3 delivers water or other liquid distally into the channel 203 from the source 211. In some cases, this flushes out obstructions. In some embodiments, the purification continues until the determination of obstructions is cancelled and / or until a preset time has elapsed. The preset time can be, for example, 50 milliseconds, 100 milliseconds, 200 milliseconds, 500 milliseconds, 1000 milliseconds, any time in between, or a longer or shorter time. In some embodiments, if a potentially dangerous pressure level is determined in the colon, the purification routine is stopped (e.g., the purification pump 214.3 is stopped). In some embodiments, the duration of the purification routine is determined by input from the operator of the device. In some embodiments, the purification includes a series of subdivided purification operations and / or purification stages as described below. In some embodiments, in step 1018, the controller 213 activates the purification pump 214.3. The purification pump 214.3 delivers water or other liquid distally into the channel 203 from the source 211. In some cases, this flushes out obstructions. In some embodiments, the purification continues until the determination of obstructions is cancelled and / or until a preset time has elapsed. The preset time can be, for example, 50 milliseconds, 100 milliseconds, 200 milliseconds, 500 milliseconds, 1000 milliseconds, any time in between, or a longer or shorter time. In some embodiments, if a potentially dangerous pressure level is determined in the colon, the purification routine is stopped (e.g., the purification pump 214.3 is stopped). In some embodiments, the duration of the purification routine is determined by input from the operator of the device. In some embodiments, the purification includes a series of subdivided purification operations and / or purification stages as described below. In some embodiments, in step 1018, the controller 213 activates the purification pump 214.3. The purification pump 214.3 delivers water or other liquid distally into the channel 203 from the source 211. In some cases, this flushes out obstructions. In some embodiments, the purification continues until the determination of obstructions is cancelled and / or until a preset time has elapsed. The preset time can be, for example, 50 milliseconds, 100 milliseconds, 200 milliseconds, 500 milliseconds, 1000 milliseconds, any time in between, or a longer or shorter time. In some embodiments, if a potentially dangerous pressure level is determined in the colon, the purification routine is stopped (e.g., the purification pump 214.3 is stopped). In some embodiments, the duration of the purification routine is determined by input from the operator of the device. In some embodiments, the purification includes a series of subdivided purification operations and / or purification stages as described below. In some embodiments, in step 1018, the controller 213 activates the purification pump 214.3. The purification pump 214.3 delivers water or other liquid distally into the channel 203 from the source 211. In some cases, this flushes out obstructions. In some embodiments, the purification continues until the determination of obstructions is cancelled and / or until a preset time has elapsed. The preset time can be, for example, 50 milliseconds, 100 milliseconds, 200 milliseconds, 500 milliseconds, 1000 milliseconds, any time in between, or a longer or shorter time. In some embodiments, if a potentially dangerous pressure level is determined in the colon, the purification routine is stopped (e.g., the purification pump 214.3 is stopped). In some embodiments, the duration of the purification routine is determined by input from the operator of the device. In some embodiments, the purification includes a series of subdivided purification operations and / or purification stages as described below. In some embodiments, in step 1018, the controller 213 activates the purification pump 214.3. The purification pump 214.3 delivers water or other liquid distally into the channel 203 from the source 211. In some cases, this flushes out obstructions. In some embodiments, the purification continues until the determination of obstructions is cancelled and / or until a preset time has elapsed. The preset time can be, for example, 50 milliseconds, 100 milliseconds, 200 milliseconds, 500 milliseconds, 1000 milliseconds, any time in between, or a longer or shorter time. In some embodiments, if a potentially dangerous pressure level is determined in the colon, the purification routine is stopped (e.g., the purification pump 214.3 is stopped). In some embodiments, the duration of the purification routine is determined by input from the operator of the device. In some embodiments, the purification includes a series of subdivided purification operations and / or purification stages as described below. In some embodiments, in step 1018, the controller 213 activates the purification pump 214.3. The purification pump 214.3 delivers water or other liquid distally into the channel 203 from the source 211. In some cases, this flushes out obstructions. In some embodiments, the purification continues until the determination of obstructions is cancelled and / or until a preset time has elapsed. The preset time can be, for example, 50 milliseconds, 100 milliseconds, 200 milliseconds, 500 milliseconds, 1000 milliseconds, any time in between, or a longer or shorter time. In some embodiments, if a potentially dangerous pressure level is determined in the colon, the purification routine is stopped (e.g., the purification pump 214.3 is stopped). In some embodiments, the duration of the purification routine is determined by input from the operator of the device. In some embodiments, the purification includes a series of subdivided purification operations and / or purification stages as described below. In some embodiments, in step 1018, the controller 213 activates the purification pump 214.3. The purification pump 214.3 delivers water or other liquid distally into the channel 203 from the source 211. In some cases, this flushes out obstructions. In some embodiments, the purification continues until the determination of obstructions is cancelled and / or until a preset time has elapsed. The preset time can be, for example, 50 milliseconds, 100 milliseconds, 200 milliseconds, 500 milliseconds, 1000 milliseconds, any time in between, or a longer or shorter time. In some embodiments, if a potentially dangerous pressure level is determined in the colon, the purification routine is stopped (e.g., the purification pump 214.3 is stopped). In some embodiments, the duration of the purification routine is determined by input from the operator of the device. In some embodiments, the purification includes a series of subdivided purification operations and / or purification stages as described below. In some embodiments, in step 1018, the controller 213 activates the purification pump 214.3. The purification pump 214.3 delivers water or other liquid distally into the channel 203 from the source 211. In some cases, this flushes out obstructions. In some embodiments, the purification continues until the determination of obstructions is cancelled and / or until a preset time has elapsed. The preset time can be, for example, 50 milliseconds, 100 milliseconds, 200 milliseconds, 500 milliseconds, 1000 milliseconds, any time in between, or a longer or shorter time. In some embodiments, if a potentially dangerous pressure level is determined in the colon, the purification routine is stopped (e.g., the purification pump 214.3 is stopped). In some embodiments, the duration of the purification routine is determined by input from the operator of the device. In some embodiments, the purification includes a series of subdivided purification operations and / or purification stages as described below. In some embodiments, in step 1018, the controller 213 activates the purification pump 214.3. The purification pump 214.3 delivers water or other liquid distally into the channel 203 from the source 211. In some cases, this flushes out obstructions. In some embodiments, the purification continues until the determination of obstructions is cancelled and / or until a preset time has elapsed. The preset time can be, for example, 50 milliseconds, 100 milliseconds, 200 milliseconds, 500 milliseconds, 1000 milliseconds, any time in between, or a longer or shorter time. In some embodiments, if a potentially dangerous pressure level is determined in the colon, the purification routine is stopped (e.g., the purification pump 214.3 is stopped). In some embodiments, the duration of the purification routine is determined by input from the operator of the device. In some embodiments, the purification includes a series of subdivided purification operations and / or purification stages as described below. In some embodiments, in step 1018, the controller 213 activates the purification pump 214.3. The purification pump 214.3 delivers water or other liquid distally into the channel 203 from the source 211. In some cases, this flushes out obstructions. In some embodiments, the purification continues until the determination of obstructions is cancelled and / or until a preset time has elapsed. The preset time can be, for example, 50 milliseconds, 100 milliseconds, 200 milliseconds, 500 milliseconds, 1000 milliseconds, any time in between, or a longer or shorter time. In some embodiments, if a potentially dangerous pressure level is determined in the colon, the purification routine is stopped (e.g., the purification pump 214.3 is stopped). In some embodiments, the duration of the purification routine is determined by input from the operator of the device. In some embodiments, the purification includes a series of subdivided purification operations and / or purification stages as described below.

[0187] In step 1020, the suction pump source 214.4 is activated again and the purification pump 214.3 is stopped. The cleaning continues in step 1012. In step 1020, the suction pump source 214.4 is activated again and the purification pump 214.3 is stopped. The cleaning continues in step 1012.

[0188] Details of the above method are optionally varied according to embodiments of the present invention.

[0189] In some embodiments of the present invention, the function of pump 214.4 as a suction source is, e.g. This is accomplished by a metered suction source. Such a source may be, for example, connected to a central vacuum source and valved. Thus, in some embodiments, pump 21 4.4 can alternatively be considered to be valve 214.4. Optionally, valve 21 4.4 is adjustable (e.g., under the control of controller 213) so that suction The amount can be controlled to be appropriate for the determined system state.

[0190] In some embodiments, the pump 214.4 is a bi-directional pump and operates in a controlled manner during the pumping operation. The proximal flow of material in channel 203 is maintained during the purging operation, and the distal flow is maintained during the purging operation. Optionally, the purge pump 214.3 can be omitted.

[0191] It should also be noted that some individual features may be incorporated into specific exemplary embodiments and figures. However, some implementations of the system 207 may be different. It is to be understood that the embodiments include combinations of features individually shown.

[0192] For example, the figures herein show various operating positions of various embodiments of system 207. The sensors and sensing modules are shown in other figures in this specification. In an embodiment of the system 207, one of a variety of cleaning actions can be performed in response to sensor data and user instructions. The present invention provides an apparatus and method for implementing the described sensors, states, decisions, and responses. Combinations of operations performed at times are also considered embodiments of the present invention. (Tip for irrigation and drainage)

[0193] Here, refer to FIG. 7B. FIG. 7B is a diagram schematically showing a tip 14 used at the distal end of the insertion tube 13 of a colon cleansing system according to some exemplary embodiments of the present invention. .

[0194] In some embodiments of the present invention, the tip 14 has an adapter member 100 attached to the distal end of the insertion tube of the colonoscope 10. In some embodiments, the adapter member 100 has a plurality of suction channels that receive supply from the suction inlet 101 in fluid communication with the corresponding plurality of colonoscope working channels 15A and 15B. In some embodiments, the suction channel opening 1 01 has a shape with a larger diameter in the distal direction that tapers to fit these dimensions at the junction with the working channels 15A and 15B. An advantage that can be considered for the adapter member 100 is that the suction applied to the channels 15A and 15B can be dispersed over a wide surface area on the distal side. It is considered that the fluid can easily enter the wide end of the channel suction inlet 101. In some embodiments of the present invention, the tip 14 has a manifold, whereby the irrigation channel is divided into two, three, four or more outlets. Optionally, the outlet shapes the irrigation fluid into a fluid jet, whereby substances can be more effectively washed from the colon wall. In some embodiments, the tip 14 has a pressure sensor for sampling the pressure near the tip of the cleansing system and / or the colonoscope. 01 tapers to fit these dimensions at the junction with the working channels 15A and 15B. An advantage that can be considered for the adapter member 100 is that the suction applied to the channels 15A and 15B can be dispersed over a wide surface area on the distal side. It is considered that the fluid can easily enter the wide end of the channel suction inlet 101. In some embodiments of the present invention, the tip 14 has a manifold, whereby the irrigation channel is divided into two, three, four or more outlets. Optionally, the outlet shapes the irrigation fluid into a fluid jet, whereby substances can be more effectively washed from the colon wall. In some embodiments, the tip 14 has a pressure sensor for sampling the pressure near the tip of the cleansing system and / or the colonoscope. is that it can disperse the suction applied to the channels 15A and 15B over a wide surface area on the distal side. The fluid is considered to easily enter the wide end of the channel suction inlet 101. In some embodiments of the present invention, the tip 14 has a manifold, whereby the irrigation channel is divided into two, three, four or more outlets. Optionally, the outlet shapes the irrigation fluid into a fluid jet, whereby substances can be more effectively washed from the colon wall. In some embodiments, the tip 14 has a pressure sensor for sampling the pressure near the tip of the cleansing system and / or the colonoscope. Optionally, the outlet shapes the irrigation fluid into a fluid jet, whereby substances can be more effectively washed from the colon wall. In some embodiments, the tip 14 has a pressure sensor for sampling the pressure near the tip of the cleansing system and / or the colonoscope. and / or near the tip of the colonoscope.

[0195] Of particular note, due to the design of the adapter member 100, the use of two or more channels is adopted for the function of the colon cleaning device. Hereinafter, further details and possible advantages of a plurality of irrigation and / or water washing channels will be described. (Colonoscope cleaning system having a plurality of channels)

[0196] Referring now to FIG. 7A, FIG. 7A schematically shows a cleaning workstation 31 provided with a plurality of irrigation and / or discharge channels, according to some exemplary embodiments of the present invention.

[0197] In some embodiments, the pump 32 at the workstation outlet has a pump 32A for supplying gas and a pump 32W for supplying water.

[0198] In some embodiments of the present invention, the gas supply pump 32A and the water supply pump 32W operate simultaneously. In some embodiments, the gas and water supplied under pressure are mixed (e.g., at the colonoscope workstation 19 or the colonoscope workstation 31) and then fed to the insertion tube 13. In some embodiments, the gas and water are mixed at the tip 14 as they exit their respective irrigation channels. Optionally, the gas supply pump 32A and the water supply pump 32W operate separately and / or alternately. The gas supplied by the pump 32A is, for example, air or carbon dioxide.

[0199] An advantage that can be considered by supplying the mixed gas and water for irrigation is that the speed, thoroughness and / or particle crushing during the cleaning of the colon 1 are promoted. In some cases, fecal matter ​Time variations imposed by vortices of gas and water formed alternately in the infusion substance during the mixing stage are relaxed and / or decomposed by the force. Also, in some cases, the gas carried into the cracks of the fecal matter under the compression pressure contributes to the decomposition of the agglomerated fecal matter when the pressure is released.

[0200] In some embodiments, the discharge pump 34 has a plurality of inlets for a plurality of discharge pipes 35A and 35B. In some embodiments, the colonoscope handle 12 has a plurality of working channel inlets 21A and 21B connected to the channels of the discharge pipes 35A and 35B. In some embodiments, the working channel inlets 21A and 2 1B themselves are connected to a plurality of independent or substantially independent working channels 15A and 15B. In some embodiments, the working channels 15A and 15B are the working channels of the colonoscope . In some embodiments, the plurality of discharge channels can be operated independently. In some embodiments, the channel operation has reversibility, for example, for purifying obstructions . . In some embodiments, the plurality of discharge channels can be operated independently. In some embodiments, the channel operation has reversibility, for example, for purifying obstructions .

[0201] An advantage contemplated for the plurality of discharge channels is that the cross-sectional area of the lumen through which the discharge is performed increases . It is considered that the increase in the cross-sectional area of the lumen improves the efficiency of discharge, for example, the discharge rate. In some cases, sufficient discharge performance is achieved by a single unobstructed channel , and another channel is optionally kept as a spare. Optionally, both channels are used in combination, but the discharge performance is maintained even after a defect in one occurs due to an obstruction during the process . Optionally, for example, by reversing the direction of the flow, one channel One channel is used to continue discharging excrement, while on the other channel, purification of obstructions is performed.

[0202] Another possible advantage of multiple discharge channels is that the maximum diameter of the tube 13 inserted into the colon is reduced compared to its discharge effect. For example, with a single discharge channel having a diameter of 5 millimeters, at least 5 millimeters is added to the maximum diameter of the insertion tube 13. The same cross-sectional area can be achieved, for example, by two tubes each having a diameter of 3.5 millimeters, and accordingly, the size added to the maximum cross-section of the insertion tube becomes smaller.

[0203] It should be noted that non-circular shapes are also possible. However, in some cases, non-circular shapes increase the risk of obstructions even with the same cross-sectional area. For example, the minimum diameter of the channel affects the maximum size of the minimum diameter of the particles that can pass through the channel. Also, for example, non-circular channels increase the area of gentle flow, which may thereby increase the vulnerability to obstructions.

[0204] According to an embodiment, the inner diameter of the discharge channel is, for example, 2.1 millimeters, 3 millimeters, 4 millimeters, 4.2 millimeters, 4.5 millimeters, 5 millimeters, 5 .5 millimeters, 6 millimeters, other diameters larger or smaller than these, or , any diameter between these. According to an embodiment in which a plurality of channels are provided, the number of discharge channels provided is, for example, 2, 3, 4 or more.

[0205] An advantage that can be considered by reducing the diameter of the insertion tube is that the flexibility of the insertion tube 13 is increased. Also, as flexibility increases, the likelihood of successfully guiding the tube to the end of the colon increases, and as a result, colonoscopy can be performed smoothly.

[0206] In some embodiments, the channels are connected and / or integrated along a portion of these lengths. For example, the discharge tubes 35A and 35B can be operated through a single input port of the discharge pump 34. Also, for example, the working channels 15A and 15B can be joined at a location before reaching the tip 14, for example, by adding a unique design or attachment (not shown). The optimal joining location near the proximal end of the channel can be, for example, within 10 centimeters, 20 centimeters, 40 centimeters, 100 centimeters, any length between these, or longer or shorter lengths from the proximal end. The optimal joining location near the distal end can be, for example, within 1 centimeter, 2 centimeters, 4 centimeters, 10 centimeters, 20 centimeters, 40 centimeters, 100 centimeters, any length between these, or longer or shorter lengths from the distal end.

[0207]

[0208] An advantage considered by joining the discharge tubes 35A and 35B proximally along a portion of these lengths is that, for example, the cost of the tube or pump member can be reduced. Another advantage considered by joining or integrating the discharge tubes 35A and 35B is that a tube with a practically large diameter can be shared. This is, optionally, the portion of the channel that is outside the colon during operation.

[0208] ​The possible advantages of the discharge pipes 15A and 15B connected in the distal direction are that obstacles can be bypassed . As an example, the two discharge channels each receive supply from the same two (shared ) input ports at the tip 14. Thus, an obstacle in the body of one discharge channel does not necessarily lead to a situation where the non-blocked tip opening, which could otherwise occur, becomes unusable . (Multiple discharge channels)

[0209] Here, refer to FIG. 8A. FIG. 8A is a diagram schematically showing a colon cleansing system having a plurality of discharge channels according to some embodiments of the present invention

[0210] In some exemplary embodiments of the present invention, two discharge channels 203.1 and 203 .2 interconnect the distal end of the insertion tube for colon cleansing and a workstation connected in the proximal direction . Optionally, more discharge channels are provided[[ID=2⑤]]

[0211] The possible advantage of providing a plurality of discharge channels is that the cross-section is more compact compared to an equivalent discharge performance system with a single, large-diameter discharge channel . Another possible advantage of providing a plurality of discharge channels is that the flexibility of the channels is higher compared to an equivalent discharge performance system with a single, large-diameter discharge channel . .

[0212] It should be noted that the discharge channel needs to remain open even under the application of a vacuum in order to achieve an effective function . Thus, in some embodiments of the colon cleansing device, implementations satisfied by various combinations of design parameters . Mutual restrictions are imposed according to the form. Specific points to be considered include, for example, the following: as follows: · Regarding the selection of the tube material, high rigidity has resistance to external pressure, but may inhibit flexibility. · Regarding the lumen diameter, a small inner diameter has high resistance to external pressure (especially with a given wall thickness), but the upper limit size limit point of the fecal matter particles that can pass through may become smaller (also, flexibility may be sacrificed). · Regarding the lumen shape, for example, a circular shape has no inherent collapse point, but may limit the opportunity to distribute the cross-sectional area near the center of the insertion tube. · Regarding the applied pressure gradient, a high gradient enables high-speed discharge through a tube of a given diameter, but increases the possibility of tube collapse and may also limit the degree and / or time to prevent injury.

[0213] Embodiments having a pair of divided circular lumens exhibit a practical compromise (different from the compromise shown by a single lumen) among such restrictions. Specifically, the minimum passage path is kept large enough for particles of a size considered to be an obstruction to pass through, while maintaining flexibility and / or resistance to collapse by reducing the overall diameter of the insertion tube. According to an embodiment, the channel lumen diameter is, for example, 3 millimeters, 3.5 millimeters, 4 millimeters, 4.5 millimeters, 5 millimeters, 5.5 millimeters, 6 millimeters, any distance between these, or a larger or smaller distance.

[0214] Optionally, the cross-section of the lumen can be reduced to use a more flexible material. The material can be a flexible silicone rubber, or in other cases, a substance colonoscope or colon wash ​​​​​​​​​ It can be other than the materials to be used in the manufacture of the insertion tube of the cleaning system. Flexibility The difference is, for example, 2 units, 4 units, 10 units by a Shore A durometer, this Any value between these, or a larger or smaller unit value. An exemplary insertion tube The baseline value by the Shore A durometer is 50 - 70 Shore A durometer units. In some embodiments, 40 - 50 or 70 - 80 is used with a Shore A durometer. Note As a point to note, the pressurized fluid supplied to the insertion tube by the colon cleaning system may, in some cases allow for limited control over the flexibility of the tube. Also, in some cases, (in a non - pressurized state) a tube that is essentially flexible can be hardened by pressure as needed during tube insertion

[0215] In some embodiments, the discharge channels 203.1 and 203.2 are respectively connected to the bidirectional pumps 214.1 and 214.2. Both the bidirectional pumps 214.1 and 214 .2, as shown in Figure 8A, perform suction to move the substances in the channel 203.1 or 2 03.2 in the proximal direction, and perform pump operation to move the substances in the channel in the distal direction

[0216] The above - mentioned specific configurations are exemplary and not limiting. For example, in some embodiments a plurality of channels 203.1 and 203.2 are attached to a common vacuum source, a purification pump 21 4.3 and / or the bidirectional pumps 214.1, 214.2. Also, in some embodiments the channels 203.1 and 203.2 are respectively and separately connected to a discharge pump 2 14.4 (or a connector connecting to a vacuum source outside the system) and the purification pump 214.3 ​​​It is connected to both sides.

[0217] According to an embodiment, one or more perfusion pipes may be present. When providing a plurality of perfusion pipes, the pipes are adjustable individually or in combination. In the drawings, the perfusion pipe 201 operates to feed perfusion fluid to the colon, or other parts of the intestine near the distal ends of the discharge channels 203.1 and 203.2. Optionally, (as illustrated in FIG. 8F) the discharge channels 203 are connected by a bridging pipe, thereby enabling fluid to move between the channels. In cases where there are multiple perfusion pipes, the pipes are adjustable individually or in combination. In the drawings, the perfusion pipe 201 operates to feed perfusion fluid to the colon, or other parts of the intestine near the distal ends of the discharge channels 203.1 and 203.2. Optionally, (as illustrated in FIG. 8F) the discharge channels 203 are connected by a bridging pipe, thereby enabling fluid to move between the channels. operates to feed perfusion fluid to the colon, or other parts of the intestine near the distal ends of the discharge channels 203.1 and 203.2. Optionally, (as illustrated in FIG. 8F) the discharge channels 203 are connected by a bridging pipe, thereby enabling fluid to move between the channels. operates to feed perfusion fluid to the colon, or other parts of the intestine near the distal ends of the discharge channels 203.1 and 203.2. Optionally, (as illustrated in FIG. 8F) the discharge channels 203 are connected by a bridging pipe, thereby enabling fluid to move between the channels. operates to feed perfusion fluid to the colon, or other parts of the intestine near the distal ends of the discharge channels 203.1 and 203.2. Optionally, (as illustrated in FIG. 8F) the discharge channels 203 are connected by a bridging pipe, thereby enabling fluid to move between the channels.

[0218] Some embodiments having a plurality of discharge channels 203.1 and 203.2 can be configured and modified as necessary as described herein with reference to embodiments having a single discharge channel 203. The methods described herein as embodiments of the present invention can be implemented and modified as necessary using a plurality of discharge channels 203.1 and 203.2. Optionally, the channels operate individually (e.g., using individually regulated pumps and / or individually regulated perfusion). Optionally, the channels operate in tandem (e.g., by delivery and perfusion from a common source and / or separate sources controlled to operate similarly). Some embodiments having a plurality of discharge channels 203.1 and 203.2 can be configured and modified as necessary as described herein with reference to embodiments having a single discharge channel 203. The methods described herein as embodiments of the present invention can be implemented and modified as necessary using a plurality of discharge channels 203.1 and 203.2. Optionally, the channels operate individually (e.g., using individually regulated pumps and / or individually regulated perfusion). Optionally, the channels operate in tandem (e.g., by delivery and perfusion from a common source and / or separate sources controlled to operate similarly). Some embodiments having a plurality of discharge channels 203.1 and 203.2 can be configured and modified as necessary as described herein with reference to embodiments having a single discharge channel 203. The methods described herein as embodiments of the present invention can be implemented and modified as necessary using a plurality of discharge channels 203.1 and 203.2. Optionally, the channels operate individually (e.g., using individually regulated pumps and / or individually regulated perfusion). Optionally, the channels operate in tandem (e.g., by delivery and perfusion from a common source and / or separate sources controlled to operate similarly). Some embodiments having a plurality of discharge channels 203.1 and 203.2 can be configured and modified as necessary as described herein with reference to embodiments having a single discharge channel 203. The methods described herein as embodiments of the present invention can be implemented and modified as necessary using a plurality of discharge channels 203.1 and 203.2. Optionally, the channels operate individually (e.g., using individually regulated pumps and / or individually regulated perfusion). Optionally, the channels operate in tandem (e.g., by delivery and perfusion from a common source and / or separate sources controlled to operate similarly). Some embodiments having a plurality of discharge channels 203.1 and 203.2 can be configured and modified as necessary as described herein with reference to embodiments having a single discharge channel 203. The methods described herein as embodiments of the present invention can be implemented and modified as necessary using a plurality of discharge channels 203.1 and 203.2. Optionally, the channels operate individually (e.g., using individually regulated pumps and / or individually regulated perfusion). Optionally, the channels operate in tandem (e.g., by delivery and perfusion from a common source and / or separate sources controlled to operate similarly). Some embodiments having a plurality of discharge channels 203.1 and 203.2 can be configured and modified as necessary as described herein with reference to embodiments having a single discharge channel 203. The methods described herein as embodiments of the present invention can be implemented and modified as necessary using a plurality of discharge channels 203.1 and 203.2. Optionally, the channels operate individually (e.g., using individually regulated pumps and / or individually regulated perfusion). Optionally, the channels operate in tandem (e.g., by delivery and perfusion from a common source and / or separate sources controlled to operate similarly). Some embodiments having a plurality of discharge channels 203.1 and 203.2 can be configured and modified as necessary as described herein with reference to embodiments having a single discharge channel 203. The methods described herein as embodiments of the present invention can be implemented and modified as necessary using a plurality of discharge channels 203.1 and 203.2. Optionally, the channels operate individually (e.g., using individually regulated pumps and / or individually regulated perfusion). Optionally, the channels operate in tandem (e.g., by delivery and perfusion from a common source and / or separate sources controlled to operate similarly). Some embodiments having a plurality of discharge channels 203.1 and 203.2 can be configured and modified as necessary as described herein with reference to embodiments having a single discharge channel 203. The methods described herein as embodiments of the present invention can be implemented and modified as necessary using a plurality of discharge channels 203.1 and 203.2. Optionally, the channels operate individually (e.g., using individually regulated pumps and / or individually regulated perfusion). Optionally, the channels operate in tandem (e.g., by delivery and perfusion from a common source and / or separate sources controlled to operate similarly).

[0219] In some embodiments, the discharge channels 203.1 and 203.2 alternate between a first operating mode of discharging perfusion and / or excreted substances proximally in the channel and a second operating mode of purifying (pushing distally) the substances. Optionally, according to any of the methods described herein for doing this, flow detection is performed on the channels 203.1 and 203.2. In some embodiments, the discharge channels 203.1 and 203.2 alternate between a first operating mode of discharging perfusion and / or excreted substances proximally in the channel and a second operating mode of purifying (pushing distally) the substances. Optionally, according to any of the methods described herein for doing this, flow detection is performed on the channels 203.1 and 203.2. In some embodiments, the discharge channels 203.1 and 203.2 alternate between a first operating mode of discharging perfusion and / or excreted substances proximally in the channel and a second operating mode of purifying (pushing distally) the substances. Optionally, according to any of the methods described herein for doing this, flow detection is performed on the channels 203.1 and 203.2. In some embodiments, the discharge channels 203.1 and 203.2 alternate between a first operating mode of discharging perfusion and / or excreted substances proximally in the channel and a second operating mode of purifying (pushing distally) the substances. Optionally, according to any of the methods described herein for doing this, flow detection is performed on the channels 203.1 and 203.2. They are controlled separately for each one.

[0220] In some embodiments, the controller 213 adjusts the operating modes of two or more channels. For example, when the first channel 203.1 is in the purification mode, the system can be controlled so that the second channel 203.2 is in the discharge mode. The advantages that can be considered by operating the channels in opposite polarities simultaneously are that while purifying the obstructions in one channel, substances can be continuously removed from the intestine using the other channel. Also, another possible advantage is that while reducing the deposition of substances in the intestine during purification in the first channel, the purified substances can be discharged in the discharge mode in the second channel in the vicinity. In some cases, applying positive pressure to one channel to strengthen it while continuously discharging the substances that have reached inside the colon is beneficial for positioning and / or resistance to collapse. Also, another possible advantage is that the channels on both sides of the insertion tube can be alternately and partially strengthened, thereby enabling restricted control over the distal end portion inside the colon. In embodiments where a distal fluid bridge is provided between the discharge channels, it is considered that by operating the plurality of discharge channels in opposite directions simultaneously, the purified substances can be prevented from reaching the intestine. For example, substances moving in the distal direction in the first channel 203.1 can cross the fluid bridge and be discharged proximally by the second channel 203.2 to which suction is applied. Another possible advantage is that the channels on both sides of the insertion tube can be alternately and partially strengthened, thereby enabling restricted control over the distal end portion inside the colon.

[0221] In embodiments where a distal fluid bridge is provided between the discharge channels, by operating the plurality of discharge channels in opposite directions simultaneously, it is considered that the purified substances can be prevented from reaching the intestine. For example, substances moving in the distal direction in the first channel 203.1 can cross the fluid bridge and be discharged proximally by the second channel 203.2 to which suction is applied. For example, substances moving in the distal direction in the first channel 203.1 can cross the fluid bridge and be discharged proximally by the second channel 203.2 to which suction is applied. (Operation of Multiple Discharge Channels)

[0222] Here, refer to FIGS. 8B to 8E. FIGS. 8B to 8E show some exemplary embodiments of the present invention. According to an embodiment, the phase in a pair of discharge channels 203.2 and 203.1 (respectively) Exemplary plots 282 (long dashed line) and 283 (short dashed line) of relative pressure (Y-axis 280) vs. time (X-axis 281) are shown.

[0223] The pressure can be considered to be measured, for example, at the positions of pressure sensors 204.1A and 204.2A inside each of the discharge channels 203.1 and 203.2.

[0224] FIG. 8B shows the pressure display in the discharge state during non-obstructed progress. The pressure display is negative and reflects the suction of the channel. The display fluctuates relatively mildly. The fluctuations are, for example, sensor noise, particles that are not obstructions in the system, a mixture of gas and fluid in the system, and / or due to the movement of the insertion tube.

[0225] FIG. 8C shows the pressure display (corresponding to the short dashed line plot 283) during the period when an obstruction occurs and is removed from a single discharge channel 203.1. First, a pressure drop corresponding to an increase in the degree of obstruction is sensed by the sensor 204. After this minimal drop, the controller 21 3 determines that an obstructive state exists and sends a purification control signal to the pump 214.1. The resulting pressure reversal from the pump 214.1 is reflected in the subsequent rise to a high positive value of the pressure.

[0226] In some embodiments of the present invention, the pressure reversal (included in the purification operation) starts depending on the determination of other states. In some embodiments, the pressure safety condition in the colon must be satisfied before causing the reversal. Optionally, 2 that are alternately purified ​​​​​​​The pressure safety conditions using an available and operable discharge channel of the book are not stricter than the conditions when operating a single operable discharge channel and / or when two operable channels simultaneously exhibit a blocked state. The safety pressure conditions for starting purification by a single channel are, for example, less than 90 to 110 millimeters of mercury column, less than 100 to 150 millimeters of mercury column, less than 140 to 160 millimeters of mercury column, or less than 150 to 200 millimeters of mercury column. Optionally, the pressure safety conditions for starting when two operable channels can be utilized in both directions of the flow are, for example, 5 or 10 millimeters of mercury column or more (however, 200 millimeters of mercury column or less). Optionally, the pressure safety conditions for starting when simultaneously purifying two operable channels are, for example, 10 or 20 millimeters of mercury column or less. The pressure changes determined to correspond to obstructions are, for example, 10 millibars, 20 millibars, 30 millibars, 40 millibars, 100 millibars, any pressure between these, or higher or lower pressures. Optionally, it takes a minimum amount of time to determine that the pressure change corresponds to an obstruction. It is, for example, 10 milliseconds, 20 milliseconds, 40 milliseconds, 100 milliseconds, 150 milliseconds, 200 milliseconds, 400 milliseconds, any time between these, or longer or shorter times. In some embodiments of the present invention, the determination of an obstruction is a function combining time and pressure, for example, a pressure change of 10 to 20 millibars for 10 to 20 milliseconds, 20 to 50 milliseconds, 50 to 100 milliseconds, or 80 to 200 milliseconds, a pressure change of 10 to 20 millibars for 10 to 20 milliseconds, 20 to 50 milliseconds, 50 to 100 milliseconds, when two operable channels can be utilized in both directions of the flow, the starting pressure safety conditions are, for example, 5 or 10 millimeters of mercury column or more (however, 200 millimeters of mercury column or less). Optionally, when simultaneously purifying two operable channels, the starting pressure safety conditions are, for example, 10 or 20 millimeters of mercury column or less.

[0227] The pressure changes determined to correspond to obstructions are, for example, 10 millibars, 20 millibars, 30 millibars, 40 millibars, 100 millibars, any pressure between these, or higher or lower pressures. Optionally, it takes a minimum amount of time to determine that the pressure change corresponds to an obstruction. It is, for example, 10 milliseconds, 20 milliseconds, 40 milliseconds, 100 milliseconds, 150 milliseconds, 200 milliseconds, 400 milliseconds, any time between these, or longer or shorter times. In some embodiments of the present invention, the determination of an obstruction is a function combining time and pressure, for example, a pressure change of 10 to 20 millibars for 10 to 20 milliseconds, 20 to 50 milliseconds, 50 to 100 milliseconds, or 80 to 200 milliseconds, a pressure change of 10 to 20 millibars for 10 to 20 milliseconds, 20 to 50 milliseconds, 50 to 100 milliseconds, to 50 milliseconds, 50 to 100 milliseconds, or 80 to 200 milliseconds, or a pressure change of 20 to 50 millibars for 10 to 20 milliseconds, 20 to 50 milliseconds, 50 to 100 milliseconds, or 80 to 200 milliseconds. or a pressure change of 20 to 50 millibars for 10 to 20 milliseconds, 20​ or a change of 20 to 50 mbar over 80 to 200 milliseconds, 50 to 100 milliseconds or a change of 80 to 120 mbar over 100 to 200 milliseconds . In some embodiments, such changes are relative changes between two sensor readings, e.g., a relative change of 10 to 20 mbar, 15 to 40 mbar, 30 to 80 mbar or 75 to 1 00 mbar, as measured.

[0228] In some embodiments, the determination of the obstruction state is made based on the detected flow, the detected optical sensing state or other sensing states as described herein.

[0229] According to an embodiment, the pressure increase (indicated by the peak of the plot) in FIG. 8C is maintained for a certain maximum time. It is, for example, 5 milliseconds, 10 milliseconds, 20 milliseconds, 50 milliseconds, 100 milliseconds, 200 milliseconds, any time between these, or longer or shorter times. Optionally, the peak of the pressure is stopped and / or maintained until a pressure change is sensed that is determined to correspond to the detachment of the obstruction. When a determination is made to continue the discharge, the controller 213 sends a discharge control signal to the pump 214.1. The pump 214.1 reverses direction, thereby reducing the pressure and restarting the discharge.

[0230] FIG. 8D shows a series of purification operations when the obstruction remains undegraded for at least two complete cycles of purification / discharge. The purification sequence, for example, ends when a predefined period of time has elapsed and the controller 213 determines that the obstruction still exists and ​It can be carried out. Alternatively, a predetermined purification routine includes a series of purification / discharge cycles which are performed without intermediate tracking of the system's fouling state. The repeated pur ification / discharge cycles (e.g., a cycle from peak discharge pressure to purification and then back to peak discharge pressure) can have a frequency of, for example, 1 hertz, 2 hertz, 5 hertz, 10 hertz, 20 hertz, any frequency between these values, or higher or lower frequencies. The number of cycles in a series of steps can be, for example, 1 cycle, 2 cycles, 4 cycles, 10 cycles, 20 cycles, any cycle number between these values, or a larger or smaller number of cycles. The number of purification steps performed per minute can be, for example, 1 - 5, 3 - 8, 5 - 10, 8 - 20, or 15 - 30 distinguishable purification operations within each minute of system operation time. In some embodiments, the operating cycle of the flow direction (either distal / proximal or proximal / distal) during purification is, for example, calculated as a portion of the total operating cycle during which pressure is applied, and is 50%, 60% / 40%, 70% / 30%, 80% / 20%, 90% / 10% or other operating cycles for each direction. In some embodiments, for example the application of pressure, which includes 5%, 10% or 20% of the total operating cycle, is paused, during which time no pressure is applied. In some embodiments of the present invention, the parameters of the purification cycle are adaptable. For example, the controller can optionally try various purification parameters during operation and adjust the appropriate set of parameters to use based on sensor readings in a purification program that shows relative success of purification. In another example, a determination (e.g., by the controller) that a series of steps of the purification cycle are initiated together during discharge indicates a mass that forms a temporary fouling in the system

[0231] ​​​​​​is regarded as. Although it is repeatedly relaxed, it remains as a floating source that becomes an obstacle again and remains. Optionally, an iterative cycle that extends beyond the determination that the obstacle has detached cleans the channel by a process, thereby decomposing the problematic mass before continuing the discharge in a situation such as this, an adaptive purification cycle adjustment is activated. Optionally, to push the obstacle out of the discharge channel together, the fluid is sent distally by another purification program for a longer time than usual than normal.

[0232] In some embodiments of the present invention, the purification cycle reduces restrictions on the flow in the discharge lumen due to reasons other than or in addition to the mass. For example, the flow restriction caused by the partial collapse of the discharge channel under vacuum reduces the proximal pressure in the lumen of the discharge channel by causing it to decrease. In another example, the twist of the discharge lumen can be reduced by applying distal pressure and, in some cases, untwisting it. In another example, for example, the turbulent flow that occurs in the discharge channel by exceeding the threshold of the flow velocity suitable for laminar flow can be reduced by changing the magnitude and / or direction of the pressure in the discharge channel.

[0233] In some embodiments of the present invention, during purification, optionally periodically, the pressure in the same direction can be changed. For example, the purification operation can maintain the proximal pressure continuously while increasing and decreasing that pressure over time. In some cases, the change in the proximal pressure is sufficient to expel weakly attached obstacles without completely blocking the discharge. In some embodiments, the change in the pressure in the same direction can optionally be It alternates with the change in pressure in two directions. This is thought to be useful for peeling off the obstruction, for example, because the movement at the location of the obstruction increases (in order to repeatedly contract to absorb the changing pressure) in the lump portion. (For example, for repeatedly contracting to absorb the changing pressure). It is thought to help.

[0234] In FIG. 8E, an alternating purification operation sequence is shown when an obstruction in one channel occurs immediately after an obstruction in the other channel. The steps of discharge, obstruction, purification, and then back to discharge are basically as described in connection with FIG. 8C for example. As an additional point, there is a point where the channels operate separately. In some embodiments, the purification of one channel is indicated with the increase in the discharge of the other. This is possibly, for example, to maintain a substantial discharge effect of the fluid in the colon. The steps of discharge, obstruction, purification, and then back to discharge are basically as described in connection with FIG. 8C for example. As an additional point, there is a point where the channels operate separately. In some embodiments, the purification of one channel is indicated with the increase in the discharge of the other. This is possibly, for example, to maintain a substantial discharge effect of the fluid in the colon. The steps of discharge, obstruction, purification, and then back to discharge are basically as described in connection with FIG. 8C for example. As an additional point, there is a point where the channels operate separately. In some embodiments, the purification of one channel is indicated with the increase in the discharge of the other. This is possibly, for example, to maintain a substantial discharge effect of the fluid in the colon. Here, with reference to FIG. 8F. FIG. 8F is a diagram showing a fluid bridge 230.1 between discharge channels according to some exemplary embodiments of the present invention. In some embodiments of the present invention, a bridge 230.1 through which fluid and / or excrement can pass is provided, for example, by a part of the tip head attachment 230, and communicates between two discharge channels 204.3 and 204.4. In some embodiments of the present invention, a sensor 230.2 such as a pressure sensor for monitoring the state within the bridge 230.1 is arranged. In some embodiments of the present invention, a bridge 230.1 through which fluid and / or excrement can pass is provided, for example, by a part of the tip head attachment 230, and communicates between two discharge channels 204.3 and 204.4. In some embodiments of the present invention, a sensor 230.2 such as a pressure sensor for monitoring the state within the bridge 230.1 is arranged.

[0235] Here, with reference to FIG. 8F. FIG. 8F is a diagram showing a fluid bridge 230.1 between discharge channels according to some exemplary embodiments of the present invention. Here, with reference to FIG. 8F. FIG. 8F is a diagram showing a fluid bridge 230.1 between discharge channels according to some exemplary embodiments of the present invention.

[0236] In some embodiments of the present invention, a bridge 230.1 through which fluid and / or excrement can pass is provided, for example, by a part of the tip head attachment 230, and communicates between two discharge channels 204.3 and 204.4. In some embodiments of the present invention, a sensor 230.2 such as a pressure sensor for monitoring the state within the bridge 230.1 is arranged. In some embodiments of the present invention, a bridge 230.1 through which fluid and / or excrement can pass is provided, for example, by a part of the tip head attachment 230, and communicates between two discharge channels 204.3 and 204.4. In some embodiments of the present invention, a sensor 230.2 such as a pressure sensor for monitoring the state within the bridge 230.1 is arranged. In some embodiments of the present invention, a bridge 230.1 through which fluid and / or excrement can pass is provided, for example, by a part of the tip head attachment 230, and communicates between two discharge channels 204.3 and 204.4. In some embodiments of the present invention, a sensor 230.2 such as a pressure sensor for monitoring the state within the bridge 230.1 is arranged. arranged.

[0237] In some embodiments, the fluid bridge 230.1 functions in sensing when at least a part of one of the inlets of the bridged discharge channels 204.3 and 204.4 is blocked. In some embodiments of the present invention, the pressure difference caused by the obstruction In some embodiments, the fluid bridge 230.1 functions in sensing when at least a part of one of the inlets of the bridged discharge channels 204.3 and 204.4 is blocked. In some embodiments of the present invention, the pressure difference caused by the obstruction In some embodiments, the fluid bridge 230.1 functions in sensing when at least a part of one of the inlets of the bridged discharge channels 204.3 and 204.4 is blocked. In some embodiments of the present invention, the pressure difference caused by the obstruction Part of the fluid flowing in from the suction inlet of the non-occluded channel opening is directed through the bridge towards the occluded channel. This causes changes that will be sensed, such as a pressure drop or signs of flow, which are optionally utilized as indications of obstruction formation at the distal end. In some embodiments of the present invention, the bridge 230.1 enables the sharing of a single tip port by two or more channels. Thereby, it is considered that most of the discharge performance can be maintained even if one of the suction inlets is occluded during use. (Disposable pipe device)

[0238] Here, refer to FIG. 9A. FIG. 9A schematically shows a cleaning workstation 31 using a tube assembly 30 attached to a colonoscope having an irrigation pipe 33A and a discharge pipe 35A according to some exemplary embodiments of the present invention. Also, refer to FIG. 9B. FIG. 9B schematically shows an exemplary cleaning workstation 31 where the disposable tube assembly 30 has a gas pipe 33A and a water pipe 33W for the irrigation pipe 35A and the discharge pipe 35B. Further, refer to FIG. 10. FIG. 10 schematically shows an exemplary colonoscope workstation 19 operating adjacent to the cleaning workstation 31. .

[0239] In some embodiments of the present invention, the attached tube assembly 30 is a tube inserted into the colon. In some embodiments of the present invention, the tube assembly 30 is disposable. Optionally, the assembly is used for irrigation when the colonoscope is not in use.

[0240] Using the disposable tube assembly 30 for the part of the colonoscope cleaning system that contacts the patient​​​​​​​​​​​​​ An advantage that can be considered is that there is no need for cleaning and / or resterilization for each use. Disposable Another advantage that can be considered for the disposable tube assembly 30 is that it can be quickly replaced even if an obstruction that cannot be recovered occurs in the tubes of the disposable tube assembly 30.

[0241] In some embodiments of the present invention, the attached tube assembly 30 can be attached to the colonoscope and inserted into the colon 1 together with the colonoscope insertion tube 13. In some embodiments, the disposable tube assembly 30 has a water pipe 33W and a gas pipe 33S that cooperate for perfusion and / or sensing. In some embodiments, the discharge pipes 35A and 35B operate in cooperation and / or separately to perform discharge.

[0242] An advantage that can be considered for the attached tube assembly 30 is that the colon cleansing system can be used together with an existing colonoscope system as, for example, a retrofit component. Another advantage that can be considered for the attached tube assembly is that the existing channels of the colonoscope, for example, the working channel, can be kept in a usable state.

[0243] In some embodiments, the pumps 32S and 32W supply different perfusion substances (for example, gas and water) through the tubes 33W and 33S and through the disposable tube assembly 30 to the distal end 14 of the colonoscope. In some embodiments, the pump 32S generates a pressure used for remote pressure sensing as described with reference to FIGS. 3A to 3E. In some embodiments, the pump 34 generates a pressure difference, whereby the perfusion substance is discharged from the distal end 14 of the colonoscope through the tubes 35A and 35B and through the disposable tube assembly 30 to the fluid reservoir. It moves into the device 8. In some embodiments, the colonoscope tip 14 thus supplies both the perfusion substance and the perfusion substance discharge during the cleaning of the fecal matter 2 from the colon 1. During the cleaning of the fecal matter 2, both the perfusion substance and the perfusion substance discharge are supplied.

[0244] In some embodiments of the present invention, the colonoscope workstation 19 independently discharges the fecal matter. In some embodiments, the pressure difference for suction is generated by the vacuum wall inlet 6 through the regulator 7 and via the pipe 9. In some embodiments, the pipe 9 is further connected to the inner pipe 11, the insertion tube 13, and the tip 14 of the colonoscope through the inlet 17. This series of connections enables the fecal matter 2 to be collected from the tip 14 into the container 8. (Cleaning system with disposable tube assembly)

[0245] Here, refer to FIG. 11. FIG. 11 schematically shows an exemplary colon cleaning system having an attached tube assembly and two bidirectional pumps together with a colonoscope according to some exemplary embodiments of the present invention.

[0246] In some embodiments of the present invention, the cleaning system 207 is attached to the probe of the colonoscope 10. In some embodiments, a disposable tube assembly 293 is formed with the discharge tubes 35.1 and 35.2 and the perfusion tube 201. The disposable tube assembly 293 and the colonoscope insertion tube 13 are assembled to the common distal end housing 290 at the tip. The disposable tube assembly 293, together with the insertion tube 13, is inserted into the colon 1 to discharge the fecal matter 2. Suction 271 and discharge 270 are controlled by the workstation 210 as described above in this specification.

[0247] ​​​​​​​​​​In some embodiments of the present invention, the distal head housing 290 is a sensor 204.2 and 204.1 connected to the workstation 210 through the tube assembly 2 93 provides a base for installation. In some embodiments, the distal head housing 290 has exhaust Outlets 290.1 and 290.2, which enable access to the working channels 20 3.1 and 203.2. In some embodiments, the distal head The housing 290 further provides a shooting port 291 and / or associated Illumination for the colonoscope imaging device 292.

[0248] An advantage that can be considered by using the head housing 290 is to enable an additional Washing function with an existing colonoscope. As described herein, some exemplary Embodiments of the present invention include a cleaning function including an irrigation channel and a discharge channel designed to meet the purpose Have a colonoscope originally designed to perform. In some embodiments, the cleaning function Is provided as a completely separate tube system that does not interfere with the existing colonoscope used together In some embodiments as shown in FIG. 11, the function of the existing colonoscope is At least partially incorporated into the cleaning. Optionally, one or more colonoscope channels Are used as discharge channels for removing the irrigating substance from the colon at least part of the time Optionally, functions such as irrigation and detection of irrigation fluid are performed by one or more accessories provided by the cleaning system Realized. In such embodiments, the head ha The using 290 optionally serves to incorporate the configuration of the colonoscope into the configuration of the cleaning system In addition, in some embodiments, some of the tubes are used as cleaning or working channels By making the portion available, the overall probe diameter can be reduced below the diameter required to separately support each function.

[0249] As used herein, the term "about" means within ±10%.

[0250] The terms "comprising," "including," "having," and their root words mean "including but not limited to."

[0251] The term "consisting of" means "including and limited to."

[0252] The term "substantially consisting of" means that a composition, method, or construction may include additional materials, steps, and / or portions, provided that the additional materials, steps, and / or portions do not materially alter the basic and novel characteristics of the claimed materials, steps, and / or portions.

[0253] As used herein, the singular forms "a," "an," and "the" include plural referents unless the context clearly indicates otherwise. For example, "a compound" or "at least one compound" may include a plurality of compounds including mixtures thereof.

[0254] As used herein, the terms "example" and "exemplary" mean "an example, instance, illustration." Any embodiment described as "example" or "exemplary" is not necessarily to be construed as preferred or otherwise excluding the incorporation of features of other embodiments.

[0255] As used herein, the term "optional" means "used in some embodiments but not in others". Specific embodiments of the present invention all have a plurality of "optional" characteristics, provided that this is not the case when such features are contradictory. As used herein, the term "optional" means "used in some embodiments but not in others". Specific embodiments of the present invention all have a plurality of "optional" characteristics, provided that this is not the case when such features are contradictory. As used herein, the term "optional" means "used in some embodiments but not in others". Specific embodiments of the present invention all have a plurality of "optional" characteristics, provided that this is not the case when such features are contradictory. As used herein, the term "optional" means "used in some embodiments but not in others". Specific embodiments of the present invention all have a plurality of "optional" characteristics, provided that this is not the case when such features are contradictory.

[0256] As used herein, the term "method" means, for example, but is not limited to, aspects, means, techniques, and procedures known to those skilled in the art of chemistry, pharmacy, biology, biochemistry, and medicine, or aspects, means, techniques, and procedures that can be readily created from known aspects, means, techniques, and procedures, for realizing a given task. As used herein, the term "method" means, for example, but is not limited to, aspects, means, techniques, and procedures known to those skilled in the art of chemistry, pharmacy, biology, biochemistry, and medicine, or aspects, means, techniques, and procedures that can be readily created from known aspects, means, techniques, and procedures, for realizing a given task. As used herein, the term "method" means, for example, but is not limited to, aspects, means, techniques, and procedures known to those skilled in the art of chemistry, pharmacy, biology, biochemistry, and medicine, or aspects, means, techniques, and procedures that can be readily created from known aspects, means, techniques, and procedures, for realizing a given task. As used herein, the term "method" means, for example, but is not limited to, aspects, means, techniques, and procedures known to those skilled in the art of chemistry, pharmacy, biology, biochemistry, and medicine, or aspects, means, techniques, and procedures that can be readily created from known aspects, means, techniques, and procedures, for realizing a given task.

[0257] In this application, various embodiments of the present invention may be presented in a range format. The description in range format is only used for convenience and simplicity and should not be understood as limiting the scope of the present invention in an immutable form. Therefore, it should be understood that the description of the range discloses not only the individual numerical values included within the range but also all possible sub-ranges. For example, the description of the range from 1 to 6 should be interpreted as disclosing not only the individual numerical values included within the range, such as 1, 2, 3, 4, 5, and 6, but also sub-ranges such as 1 to 3, 1 to 4, 1 to 5, 2 to 4, 2 to 6, and 3 to 6. This applies regardless of the width of the range. In this application, various embodiments of the present invention may be presented in a range format. The description in range format is only used for convenience and simplicity and should not be understood as limiting the scope of the present invention in an immutable form. Therefore, it should be understood that the description of the range discloses not only the individual numerical values included within the range but also all possible sub-ranges. For example, the description of the range from 1 to 6 should be interpreted as disclosing not only the individual numerical values included within the range, such as 1, 2, 3, 4, 5, and 6, but also sub-ranges such as 1 to 3, 1 to 4, 1 to 5, 2 to 4, 2 to 6, and 3 to 6. This applies regardless of the width of the range. In this application, various embodiments of the present invention may be presented in a range format. The description in range format is only used for convenience and simplicity and should not be understood as limiting the scope of the present invention in an immutable form. Therefore, it should be understood that the description of the range discloses not only the individual numerical values included within the range but also all possible sub-ranges. For example, the description of the range from 1 to 6 should be interpreted as disclosing not only the individual numerical values included within the range, such as 1, 2, 3, 4, 5, and 6, but also sub-ranges such as 1 to 3, 1 to 4, 1 to 5, 2 to 4, 2 to 6, and 3 to 6. This applies regardless of the width of the range. In this application, various embodiments of the present invention may be presented in a range format. The description in range format is only used for convenience and simplicity and should not be understood as limiting the scope of the present invention in an immutable form. Therefore, it should be understood that the description of the range discloses not only the individual numerical values included within the range but also all possible sub-ranges. For example, the description of the range from 1 to 6 should be interpreted as disclosing not only the individual numerical values included within the range, such as 1, 2, 3, 4, 5, and 6, but also sub-ranges such as 1 to 3, 1 to 4, 1 to 5, 2 to 4, 2 to 6, and 3 to 6. This applies regardless of the width of the range. In this application, various embodiments of the present invention may be presented in a range format. The description in range format is only used for convenience and simplicity and should not be understood as limiting the scope of the present invention in an immutable form. Therefore, it should be understood that the description of the range discloses not only the individual numerical values included within the range but also all possible sub-ranges. For example, the description of the range from 1 to 6 should be interpreted as disclosing not only the individual numerical values included within the range, such as 1, 2, 3, 4, 5, and 6, but also sub-ranges such as 1 to 3, 1 to 4, 1 to 5, 2 to 4, 2 to 6, and 3 to 6. This applies regardless of the width of the range. In this application, various embodiments of the present invention may be presented in a range format. The description in range format is only used for convenience and simplicity and should not be understood as limiting the scope of the present invention in an immutable form. Therefore, it should be understood that the description of the range discloses not only the individual numerical values included within the range but also all possible sub-ranges. For example, the description of the range from 1 to 6 should be interpreted as disclosing not only the individual numerical values included within the range, such as 1, 2, 3, 4, 5, and 6, but also sub-ranges such as 1 to 3, 1 to 4, 1 to 5, 2 to 4, 2 to 6, and 3 to 6. This applies regardless of the width of the range. In this application, various embodiments of the present invention may be presented in a range format. The description in range format is only used for convenience and simplicity and should not be understood as limiting the scope of the present invention in an immutable form. Therefore, it should be understood that the description of the range discloses not only the individual numerical values included within the range but also all possible sub-ranges. For example, the description of the range from 1 to 6 should be interpreted as disclosing not only the individual numerical values included within the range, such as 1, 2, 3, 4, 5, and 6, but also sub-ranges such as 1 to 3, 1 to 4, 1 to 5, 2 to 4, 2 to 6, and 3 to 6. This applies regardless of the width of the range. In this application, various embodiments of the present invention may be presented in a range format. The description in range format is only used for convenience and simplicity and should not be understood as limiting the scope of the present invention in an immutable form. Therefore, it should be understood that the description of the range discloses not only the individual numerical values included within the range but also all possible sub-ranges. For example, the description of the range from 1 to 6 should be interpreted as disclosing not only the individual numerical values included within the range, such as 1, 2, 3, 4, 5, and 6, but also sub-ranges such as 1 to 3, 1 to 4, 1 to 5, 2 to 4, 2 to 6, and 3 to 6. This applies regardless of the width of the range.

[0258] When a numerical range is indicated in this specification, it is always intended to include any recited numerical value (fraction or integer) within the indicated range. As used herein, the term "..." When a numerical range is indicated in this specification, it is always intended to include any recited numerical value (fraction or integer) within the indicated range. As used herein, the term "..." The phrase "range between" the first number shown and the next number shown, and the phrase "range from" the first number shown "to" the next number shown are interchangeable and are intended to include the first number shown, the next number shown, and all fractions and integers therebetween. As will be understood, certain features of the invention, which are, for clarity, described in the context of separate embodiments, may be implemented in combination in a single embodiment. Conversely, the various features of the invention that are, for clarity, described in the context of a single embodiment may be implemented separately or in any suitable sub-combination or, as appropriate, in other embodiments of the invention. Specific features described in the context of various embodiments are not to be considered essential features of those embodiments, except in cases where an embodiment is inoperative without those elements.

[0259] As will be understood, certain features of the invention, which are, for clarity, described in the context of separate embodiments, may be implemented in combination in a single embodiment. Conversely, the various features of the invention that are, for clarity, described in the context of a single embodiment may be implemented separately or in any suitable sub-combination or, as appropriate, in other embodiments of the invention. Specific features described in the context of various embodiments are not to be considered essential features of those embodiments, except in cases where an embodiment is inoperative without those elements. As will be understood, certain features of the invention, which are, for clarity, described in the context of separate embodiments, may be implemented in combination in a single embodiment. Conversely, the various features of the invention that are, for clarity, described in the context of a single embodiment may be implemented separately or in any suitable sub-combination or, as appropriate, in other embodiments of the invention. Specific features described in the context of various embodiments are not to be considered essential features of those embodiments, except in cases where an embodiment is inoperative without those elements. As will be understood, certain features of the invention, which are, for clarity, described in the context of separate embodiments, may be implemented in combination in a single embodiment.

Claims

**Claim 1** A system for washing the intestine, comprising: a discharge lumen for discharging perfusion fluid from the intestine; a pressure source; at least one sensor positioned to detect environmental conditions in or near the discharge lumen; a controller, which determines the presence of a partial obstruction in the discharge lumen by measuring a pressure change in the discharge lumen based on a notification from the at least one sensor before the partial obstruction in the discharge lumen causes a decrease in flow through the discharge lumen at any rate exceeding 20%, wherein the decrease in flow is an increase in pressure in the discharge lumen; determines an increase rate of the partial obstruction based on a rate of change of the pressure change in the discharge lumen; and a controller configured to adjust the pressure from the pressure source for purifying the partial obstruction based on the increase rate of the partial obstruction. A system having the above components. **Claim 2** The system according to claim 1, wherein the partial obstruction is an increasing obstruction that increases the obstruction of the discharge lumen, and the system causes a rate of decrease in discharge due to the increasing obstruction of the discharge lumen. **Claim 3** The system according to claim 1 or 2, wherein when the controller determines a pressure change indicating that the partial obstruction is an increasing obstruction that occurs more rapidly than a preselected threshold of rapidly occurring pressure changes, the controller is configured to immediately adjust the pressure from the pressure source for purifying the partial obstruction. **Claim 4** The system according to any one of claims 1 to 3, wherein the controller is configured to determine the possibility of the presence of the partial obstruction while the partial obstruction forms an obstruction of less than 50% of the cross-section of the discharge lumen. **Claim 5** The system according to any one of claims 1 to 4, wherein the controller is configured to determine the possibility of the presence of the partial obstruction while the partial obstruction forms an obstruction of less than 10% of the cross-section of the discharge lumen. **Claim 6** The system according to any one of claims 1 to 5, wherein the controller is configured to set a pressure change in the flow direction sufficient to expel weakly adhered partial obstructions while continuing the discharge. **Claim 7** In the system according to any one of claims 1 to 6, the pressure source is operable to alternately apply a pressure gradient to the discharge lumen in a flow direction and a direction opposite to the flow direction, the system.

8. In the system according to any one of claims 1 to 7, being configured to adjust the pressure as described above includes being configured to adjust through at least two cycles of increasing the pressure in a direction opposite to the flow direction and then decreasing it, the system.

9. In the system according to any one of claims 1 to 8, the at least one sensor includes a plurality of sensors, being configured to determine the presence of the partial obstruction includes being configured to determine the position of the partial obstruction in the system, and the pressure is adjusted based on the position, the system.

10. In the system according to claim 9, the plurality of sensors are configured to detect a pressure difference within the discharge lumen before and after the partial obstruction, the system.

11. In the system according to any one of claims 1 to 10, the controller is configured to re-determine the presence of the partial obstruction during the adjustment of the pressure as described above and control the adjustment of the pressure as described above based on the recognition that the presence of the partial obstruction continues, the system.

12. In the system according to any one of claims 1 to 11, the at least one sensor is one of the following groups, namely, (a) a sensor located on the outer surface of the distal portion of the discharge lumen and positioned outside the discharge lumen, (b) a sensor located inside the discharge lumen and positioned within 5 millimeters from the distal end of the discharge lumen, (c) a sensor located inside the discharge lumen and positioned within 5 to 30 millimeters from the distal end of the discharge lumen, (d) a sensor located inside the discharge lumen and positioned within 3 to 160 centimeters from the distal end of the discharge lumen, (e) a sensor located inside the discharge lumen and positioned within 160 to 250 centimeters from the distal end of the discharge lumen, (f) a sensor located inside the discharge lumen and positioned more than 250 centimeters away from the distal end of the discharge lumen, and (g) a sensor located inside a fluid supply pipe that supplies fluid flow to the distal portion of the discharge lumen and includes a plurality of sensors selected from the group consisting of, the system.

13. In the system according to any one of claims 1 to 12, being configured to determine the presence of the partial obstruction includes measuring at least any one of the following groups, namely: (a) Pressure from one or more sensors, (b) Pressure difference between two or more sensors, (c) Flow, (d) Optical characteristics, and (e) Bulk material characteristics from the sensed changes. A system.

14. In the system according to any one of claims 1 to 13, the system has a plurality of the discharge lumens, and the pressure applied to the plurality of discharge lumens by the pressure source can be individually controlled. A system.

15. In the system according to any one of claims 1 to 14, an intestinal pressure sensor positioned to measure the pressure in the intestine outside the discharge lumen, a perfusion supply channel for supplying a perfusion fluid to the intestine, the controller, determining the inflation pressure of the intestine based on a notification from the intestinal pressure sensor, and the controller configured to change the supply of the perfusion fluid to the intestine based on the above determination A system having.

16. A system for washing the intestine, a plurality of discharge lumens for discharging a perfusion fluid from the intestine, a pressure source operable to alternately apply a pressure gradient to each of the plurality of discharge lumens in a flow direction and a direction opposite to the flow direction, at least one sensor positioned to detect environmental conditions in or near the plurality of discharge lumens, wherein one or more of the at least one sensor is at least one sensor configured to notify a pressure level in the colon, the controller, measuring a pressure change in the first discharge lumen based on a notification from the at least one sensor before a partial obstruction in the first discharge lumen causes a decrease in the flow through the first discharge lumen by more than 20% of any rate, the decrease in the flow being an increase in the pressure in the first discharge lumen, and (a) determining whether the pressure level in the colon satisfies a pressure safety condition, and adjusting the pressure from the pressure source for purifying the partial obstruction only when the pressure safety condition is satisfied, and (b) a controller configured to perform either determining an increase rate of the partial obstruction based on a rate of change of pressure in the first discharge lumen and adjusting pressure from the pressure source to purify the partial obstruction based on the increase rate of the partial obstruction A system having the same.

17. The system according to claim 16, wherein the pressure safety condition is satisfied if the pressure in the colon is less than 200 millimeters of mercury.

18. The system according to claim 16, wherein the pressure safety condition is satisfied if the pressure in the colon is less than 150 millimeters of mercury.

19. A system for flushing the intestine, comprising: a discharge lumen for discharging perfusate from the intestine; a pressure source operable to alternately apply a pressure gradient to the discharge lumen in a flow direction and in a direction opposite to the flow direction; at least one sensor positioned to detect environmental conditions in or near the discharge lumen; a controller, determining the presence of the partial obstruction in the discharge lumen that causes a restriction of flow in the discharge lumen by measuring a change in pressure in the discharge lumen based on a notification from the at least one sensor before the partial obstruction in the discharge lumen causes a reduction in flow through the discharge lumen by more than 20% of any rate, the reduction in flow being an increase in pressure in the discharge lumen; determining an increase rate of the partial obstruction based on a rate of change of pressure in the discharge lumen; a controller configured to adjust pressure from the pressure source to reduce the restriction of flow based on the increase rate of the partial obstruction A system having the same.

20. The system according to claim 19, wherein the restriction of flow is at least any one selected from the group consisting of: partial lining by substances accumulated on the wall of the discharge lumen; shape change of the discharge lumen; and turbulent flow in the discharge lumen A system that is at least any one selected from the group consisting of.

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